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3,634 results on '"Larsson, L"'

113. Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

Author

Perotin, Jeanne-Marie, Schofield, James P. R., Wilson, Susan J., Ward, Jonathan, Brandsma, Joost, Strazzeri, Fabio, Bansal, Aruna, Yang, Xian, Rowe, Anthony, Corfield, Julie, Lutter, Rene, Shaw, Dominick E., Bakke, Per S., Caruso, Massimo, Dahlen, Barbro, Fowler, Stephen J., Horvath, Ildiko, Howarth, Peter, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandstrom, Thomas, Sun, Kai, Pandis, Ioannis, Auffray, Charles, De Meulder, Bertrand, Lefaudeux, Diane, Riley, John H., Sousa, Ana R., Dahlen, Sven-Erik, Adcock, Ian M., Chung, Kian Fan, Sterk, Peter J., Skipp, Paul J., Collins, Jane E., Davies, Donna E., Djukanovic, Ratko, Adcock, I. M., Ahmed, H., Auffray, C., Bakke, P., Banssal, A. T., Baribaud, F., Bates, S., Bel, E. H., Bigler, J., Bisgaard, H., Boedigheimer, M. J., Bonnelykke, K., Brandsma, J., Brinkman, P., Bucchioni, E., Burg, D., Bush, A., Caruso, M., Chaiboonchoe, A., Chanez, P., Chung, K. F., Compton, C. H., Corfield, J., D'Amico, A., Dahlen, S. E., De Meulder, B., Djukanovic, R., Erpenbeck, V. J., Erzen, D., Fichtner, K., Fitch, N., Fleming, L. J., Formaggio, E., Fowler, S. J., Frey, U., Gahlemann, M., Geiser, T., Guo, Y., Hashimoto, S., Haughney, J., Hedlin, G., Hekking, P. W., Higenbottam, T., Hohlfeld, J. M., Holweg, C., Horvath, I., Howarth, P., James, A. J., Knowles, R., Knox, A. J., Krug, N., Lefaudeux, D., Loza, M. J., Lutter, R., Manta, A., Masefield, S., Matthews, J. G., Mazein, A., Meiser, A., Middelveld, R. J. M., Miralpeix, M., Montuschi, P., Mores, N., Murray, C. S., Musial, J., Myles, D., Pahus, L., Pandis, I., Pavlidis, S., Powell, P., Pratico, G., Puig Valls, M., Rao, N., Riley, J., Roberts, A., Roberts, G., Rowe, A., Sandstrom, T., Seibold, W., Selby, A., Shaw, D. E., Sigmund, R., Singer, F., Skipp, P. J., Sousa, A. R., Sterk, P. J., Sun, K., Thornton, B., van Aalderen, W. M., van Geest, M., Vestbo, J., Vissing, N. H., Wagener, A. H., Wagers, S. S., Weiszhart, Z., Wheelock, C. E., Wilson, S. J., Aliprantis, Antonios, Allen, David, Alving, Kjell, Badorrek, P., Balgoma, David, Ballereau, S., Barber, Clair, Batuwitage, Manohara Kanangana, Bautmans, An, Bedding, A., Behndig, A. F., Beleta, Jorge, Berglind, A., Berton, A., Bochenek, G., Braun, A., Campagna, D., Carayannopoulos, L., Casaulta, C., Chaleckis, Romanas, Dahlen, B., Davison, T., De Alba, J., De Lepeleire, I., Dekker, T., Delin, I., Dennison, P., Dijkhuis, A., Dodson, P., Dyson, K., Edwards, J., El Hadjam, L., Emma, R., Ericsson, M., Faulenbach, C., Flood, Breda, Galffy, G., Gallart, H., Garissi, D., Gent, J., de Verdier, M. Gerhardsson, Gibeon, D., Gomez, Cristina, Gove, K., Guillmant-Farry, E., Henriksson, E., Hewitt, L., Hoda, U., Hu, Richard, Hu, S., Hu, X., Jeyasingham, E., Johnson, K., Jullian, N., Kamphuis, J., Kennington, E. J., Kerry, D., Kerry, G., Klueglich, M., Knobel, H., Kolmert, Johan, Konradsen, J. R., Kots, M., Kretsos, Kosmas, Krueger, L., Kuo, S., Kupczyk, M., Lambrecht, B., Lantz, A-S, Larminie, Christopher, Larsson, L. X., Latzin, P., Lazarinis, N., Lemonnier, N., Lone-Latif, S., Lowe, L. A., Marouzet, L., Martin, J., Mathon, C., McEvoy, L., Meah, S., Menzies-Gow, A., Metcalf, L., Mikus, M., Monk, P., Naz, S., Nething, K., Nicholas, B., Nihlen, U., Nilsson, Peter, Niven, R., Nordlund, B., Nsubuga, S., Ostling, J., Pacino, A., Palkonen, S., Pellet, J., Pennazza, G., Petren, A., Pink, S., Pison, C., Postle, A., Rahman-Amin, M., Ravanetti, L., Ray, E., Reinke, S., Reynolds, L., Riemann, K., Robberechts, Martine, Rocha, J. P., Rossios, C., Russell, K., Rutgers, M., Santini, G., Santoninco, M., Saqi, M., Schoelch, C., Schofield, J. P. R., Scott, S., Sehgal, N., Sjodin, M., Smids, B., Smith, Caroline, Smith, J., Smith, K. M., Soderman, P., Sogbessan, A., Spycher, F., Staykova, D., Stephan, S., Stokholm, J., Strandberg, K., Sunther, M., Szentkereszty, M., Tamasi, L., Tariq, K., Thorngren, J-O, Thorsen, Jonathan, Valente, S., van de Pol, Marianne, van Drunen, C. M., Van Eyll, J., Versnel, J., Vink, A., von Garnier, C., Vyas, A., Wald, F., Walker, S., Ward, J., Wetzel, K., Wiegman, C., Williams, S., Yang, X., Yeyasingham, E., Yu, W., Zetterquist, W., Zolkipli, Z., Zwinderman, A. H., Prins, J-B, Visintin, L., Evans, H., Puhl, M., Buzermaniene, L., Hudson, V., Bond, L., de Boer, P., Widdershoven, G., Supple, D., Hamerlijnck, D., Negus, J., Sergison, L., Onstein, S., MacNee, W., Bernardini, R., Bont, Louis, Wecksell, P-A, Draper, Aleksandra, Gozzard, Neil, Perotin, Jeanne-Marie, Schofield, James P. R., Wilson, Susan J., Ward, Jonathan, Brandsma, Joost, Strazzeri, Fabio, Bansal, Aruna, Yang, Xian, Rowe, Anthony, Corfield, Julie, Lutter, Rene, Shaw, Dominick E., Bakke, Per S., Caruso, Massimo, Dahlen, Barbro, Fowler, Stephen J., Horvath, Ildiko, Howarth, Peter, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandstrom, Thomas, Sun, Kai, Pandis, Ioannis, Auffray, Charles, De Meulder, Bertrand, Lefaudeux, Diane, Riley, John H., Sousa, Ana R., Dahlen, Sven-Erik, Adcock, Ian M., Chung, Kian Fan, Sterk, Peter J., Skipp, Paul J., Collins, Jane E., Davies, Donna E., Djukanovic, Ratko, Adcock, I. M., Ahmed, H., Auffray, C., Bakke, P., Banssal, A. T., Baribaud, F., Bates, S., Bel, E. H., Bigler, J., Bisgaard, H., Boedigheimer, M. J., Bonnelykke, K., Brandsma, J., Brinkman, P., Bucchioni, E., Burg, D., Bush, A., Caruso, M., Chaiboonchoe, A., Chanez, P., Chung, K. F., Compton, C. H., Corfield, J., D'Amico, A., Dahlen, S. E., De Meulder, B., Djukanovic, R., Erpenbeck, V. J., Erzen, D., Fichtner, K., Fitch, N., Fleming, L. J., Formaggio, E., Fowler, S. J., Frey, U., Gahlemann, M., Geiser, T., Guo, Y., Hashimoto, S., Haughney, J., Hedlin, G., Hekking, P. W., Higenbottam, T., Hohlfeld, J. M., Holweg, C., Horvath, I., Howarth, P., James, A. J., Knowles, R., Knox, A. J., Krug, N., Lefaudeux, D., Loza, M. J., Lutter, R., Manta, A., Masefield, S., Matthews, J. G., Mazein, A., Meiser, A., Middelveld, R. J. M., Miralpeix, M., Montuschi, P., Mores, N., Murray, C. S., Musial, J., Myles, D., Pahus, L., Pandis, I., Pavlidis, S., Powell, P., Pratico, G., Puig Valls, M., Rao, N., Riley, J., Roberts, A., Roberts, G., Rowe, A., Sandstrom, T., Seibold, W., Selby, A., Shaw, D. E., Sigmund, R., Singer, F., Skipp, P. J., Sousa, A. R., Sterk, P. J., Sun, K., Thornton, B., van Aalderen, W. M., van Geest, M., Vestbo, J., Vissing, N. H., Wagener, A. H., Wagers, S. S., Weiszhart, Z., Wheelock, C. E., Wilson, S. J., Aliprantis, Antonios, Allen, David, Alving, Kjell, Badorrek, P., Balgoma, David, Ballereau, S., Barber, Clair, Batuwitage, Manohara Kanangana, Bautmans, An, Bedding, A., Behndig, A. F., Beleta, Jorge, Berglind, A., Berton, A., Bochenek, G., Braun, A., Campagna, D., Carayannopoulos, L., Casaulta, C., Chaleckis, Romanas, Dahlen, B., Davison, T., De Alba, J., De Lepeleire, I., Dekker, T., Delin, I., Dennison, P., Dijkhuis, A., Dodson, P., Dyson, K., Edwards, J., El Hadjam, L., Emma, R., Ericsson, M., Faulenbach, C., Flood, Breda, Galffy, G., Gallart, H., Garissi, D., Gent, J., de Verdier, M. Gerhardsson, Gibeon, D., Gomez, Cristina, Gove, K., Guillmant-Farry, E., Henriksson, E., Hewitt, L., Hoda, U., Hu, Richard, Hu, S., Hu, X., Jeyasingham, E., Johnson, K., Jullian, N., Kamphuis, J., Kennington, E. J., Kerry, D., Kerry, G., Klueglich, M., Knobel, H., Kolmert, Johan, Konradsen, J. R., Kots, M., Kretsos, Kosmas, Krueger, L., Kuo, S., Kupczyk, M., Lambrecht, B., Lantz, A-S, Larminie, Christopher, Larsson, L. X., Latzin, P., Lazarinis, N., Lemonnier, N., Lone-Latif, S., Lowe, L. A., Marouzet, L., Martin, J., Mathon, C., McEvoy, L., Meah, S., Menzies-Gow, A., Metcalf, L., Mikus, M., Monk, P., Naz, S., Nething, K., Nicholas, B., Nihlen, U., Nilsson, Peter, Niven, R., Nordlund, B., Nsubuga, S., Ostling, J., Pacino, A., Palkonen, S., Pellet, J., Pennazza, G., Petren, A., Pink, S., Pison, C., Postle, A., Rahman-Amin, M., Ravanetti, L., Ray, E., Reinke, S., Reynolds, L., Riemann, K., Robberechts, Martine, Rocha, J. P., Rossios, C., Russell, K., Rutgers, M., Santini, G., Santoninco, M., Saqi, M., Schoelch, C., Schofield, J. P. R., Scott, S., Sehgal, N., Sjodin, M., Smids, B., Smith, Caroline, Smith, J., Smith, K. M., Soderman, P., Sogbessan, A., Spycher, F., Staykova, D., Stephan, S., Stokholm, J., Strandberg, K., Sunther, M., Szentkereszty, M., Tamasi, L., Tariq, K., Thorngren, J-O, Thorsen, Jonathan, Valente, S., van de Pol, Marianne, van Drunen, C. M., Van Eyll, J., Versnel, J., Vink, A., von Garnier, C., Vyas, A., Wald, F., Walker, S., Ward, J., Wetzel, K., Wiegman, C., Williams, S., Yang, X., Yeyasingham, E., Yu, W., Zetterquist, W., Zolkipli, Z., Zwinderman, A. H., Prins, J-B, Visintin, L., Evans, H., Puhl, M., Buzermaniene, L., Hudson, V., Bond, L., de Boer, P., Widdershoven, G., Supple, D., Hamerlijnck, D., Negus, J., Sergison, L., Onstein, S., MacNee, W., Bernardini, R., Bont, Louis, Wecksell, P-A, Draper, Aleksandra, and Gozzard, Neil

Published
2019
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114. Control of Hybrid Hydromechanical Transmissions

Author

Larsson, L. Viktor and Larsson, L. Viktor

Abstract

This thesis deals with control aspects of complex hybrid hydromechanical transmissions for heavy mobile working machines. Control problems are identified and solved to facilitate the implementation and use of these systems. Fuel prices and environmental concerns have increased the interest in hybrid hydromechanical transmissions for heavy mobile working machines. Hybridisation, the introduction of a secondary energy source in the transmission, offers attractive improvements in terms of both fuel efficiency and performance. These improvements are, in turn, enabled by software control. A complex transmission architecture has several components that need to interact in a stable manner. In addition, optimal utilisation of the added energy source is required to maximise fuel savings. Meanwhile, there is a strong trend towards automation, where many of the operator’s difficult control tasks need to be managed by computers. Sophisticated control strategies are therefore needed, along with a deeper understanding of dynamic properties. Previous research on the control of hybrid hydromechanical transmissions has primarily focussed on on-road applications. The working conditions of heavy working machines place different requirements on the transmission, which is also reflected in the control strategy. This thesis highlights the importance of fast response of the variable displacement pump/motors used in hybrid hydromechanical transmissions. Their central position in the interface between hydraulics and mechanics makes their dynamic performance a limiting factor both for the stability of the transmission control loops and in the realisation of smooth mode shifts in multiplemode transmissions. Dynamic models and control strategies for displacement actuators are derived and validated in simulation and experiments. A linear model for dynamic analysis of a general hybrid hydromechanical transmission for heavy working machines is derived and a powertrain control strategy based on de

Published
2019
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115. Low-Level Control of Hybrid Hydromechanical Transmissions for Heavy Mobile Working Machines

Author

Larsson, L. Viktor, Ericson, Liselott, Uebel (Pettersson), Karl, Krus, Petter, Larsson, L. Viktor, Ericson, Liselott, Uebel (Pettersson), Karl, and Krus, Petter

Abstract

Fuel efficiency has become an increasingly important property of heavy mobile working machines. As a result, Hybrid Hydromechanical Transmissions (HMTs) are often considered for the propulsion of these vehicles. The introduction of hybrid HMTs does, however, come with a number of control-related challenges. To date, a great focus in the literature has been on high-level control aspects, concerning optimal utilization of the energy storage medium. In contrast, the main topic of this article is low-level control, with the focus on dynamic response and the ability to realize requested power flows accurately. A static decoupled Multiple-Input-Multiple-Output (MIMO) control strategy, based on a linear model of a general hybrid HMT, is proposed. The strategy is compared to a baseline approach in Hardware-In-the-Loop (HWIL) simulations of a reference wheel loader for two drive cycles. It was found that an important benefit of the decoupled control approach is that the static error caused by the system’s cross-couplings is minimized without introducing integrating elements. This feature, combined with the strategy’s general nature, motivates its use for multiple-mode transmissions in which the transmission configuration changes between the modes., Funding agencies: Swedish Energy Agency (Energimyndigheten) [P39367-2]

Published
2019
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116. Sarcopenia; Aging-related loss of muscle mass and function

Author

Larsson, L, Degens, Hans, Li, M, Salviati, L, Lee, YI, Thompson, W, Kirkland, JL, Sandri, M, Larsson, L, Degens, Hans, Li, M, Salviati, L, Lee, YI, Thompson, W, Kirkland, JL, and Sandri, M

Abstract

Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility, diminishes quality of life, and can lead to fall-related injuries, which require costly hospitalization and extended rehabilitation. This review focuses on the aging-related structural changes and mechanisms at cellular and subcellular levels underlying changes in the individual motor unit: specifically, the perikaryon of -motoneuron, its neuromuscular junction(s), and the muscle fibers that it innervates. Loss of muscle mass with aging, which is largely due to the progressive loss of motoneurons, is associated with reduced muscle fiber number and size. Muscle function progressively declines because motoneuron loss is not adequately compensated by reinnervation of muscle fibers by the remaining motoneurons. At the intracellular level, key factors are qualitative changes in posttranslational modifications of muscle proteins and the loss of coordinated control between contractile, mitochondrial, and sarcoplasmic reticulum protein expression. Quantitative and qualitative changes in skeletal muscle during the process of aging also have been implicated in the pathogenesis of acquired and hereditary neuromuscular disorders. In experimental models, specific intervention strategies have shown encouraging results on limiting deterioration of motor unit structure and function under conditions of impaired innervation. Translated to the clinic, if these or similar interventions, by saving muscle and improving mobility, could help alleviate sarcopenia in the elderly, there would be both great humanitarian benefits and large cost savings for health care systems.

Published
2019

117. Geographical variation and predictors of physical activity level in adults with congenital heart disease

Author

Larsson, L, Johansson, B, Sandberg, C, Apers, S, Kovacs, AH, Luyckx, K, Thomet, C, Budts, W, Enomoto, J, Sluman, MA, Wang, J-K, Jackson, JL, Khairy, P, Cook, SC, Alday, L, Eriksen, K, Dellborg, M, Berghammer, M, Rempel, G, Menahem, S, Caruana, M, Tomlin, M, Soufi, A, Fernandes, SM, White, K, Callus, E, Kutty, S, Moons, P, Larsson, L, Johansson, B, Sandberg, C, Apers, S, Kovacs, AH, Luyckx, K, Thomet, C, Budts, W, Enomoto, J, Sluman, MA, Wang, J-K, Jackson, JL, Khairy, P, Cook, SC, Alday, L, Eriksen, K, Dellborg, M, Berghammer, M, Rempel, G, Menahem, S, Caruana, M, Tomlin, M, Soufi, A, Fernandes, SM, White, K, Callus, E, Kutty, S, and Moons, P

Abstract

BACKGROUND: Physical activity is important to maintain and promote health. This is of particular interest in patients with congenital heart disease (CHD) where acquired heart disease should be prevented. The World Health Organization (WHO) recommends a minimum of 2.5 h/week of physical activity exceeding 3 metabolic equivalents (METS) to achieve positive health effects. It is unknown whether physical activity levels (PAL) in adult CHD patients differ by country of origin. METHODS: 3896 adults with CHD recruited from 15 countries over 5 continents completed self-reported instruments, including the Health Behaviour Scale (HBS-CHD), within the APPROACH-IS project. For each patient, we calculated whether WHO recommendations were achieved or not. Associated factors were investigated using Generalized Linear Mixed Models. RESULTS: On average, 31% reached the WHO recommendations but with a great variation between geographical areas (India: 10%-Norway: 53%). Predictors for physical activity level in line with the WHO recommendations, with country of residence as random effect, were male sex (OR 1.78, 95%CI 1.52-2.08), NYHA-class I (OR 3.10, 95%CI 1.71-5.62) and less complex disease (OR 1.46, 95%CI 1.16-1.83). In contrast, older age (OR 0.97, 95%CI 0.96-0.98), lower educational level (OR 0.41, 95%CI 0.26-0.64) and being unemployed (OR 0.57, 95%CI 0.42-0.77) were negatively associated with reaching WHO recommendations. CONCLUSIONS: A significant proportion of patients with CHD did not reach the WHO physical activity recommendations. There was a large variation in physical activity level by country of origin. Based on identified predictors, vulnerable patients may be identified and offered specific behavioral interventions.

Published
2019

135. Airborne environmental endotoxin: a cross-validation of sampling and analysis techniques

Author

Walters, M., Milton, D., Larsson, L., and Ford T.

Subjects
Endotoxins -- Research, Gas chromatography -- Analysis, Biological sciences
Abstract

A comparison of samples with methanolysis and 3-hydroxy fatty acid (3-OHFA) analysis by gas chromatography mass spectrometry formed part of a cross validation of the extraction and assay approach to estimate air-borne environmental endotoxin. The accuracy and responsiveness of this routine approach is confirmed. The approach included analysis by the kinetic Limulus assay and sampling with a capillary-pore membrane filter.

Published
1994

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