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442 results on '"Lannin, Donald"'

105. Brief-exposure to preoperative bevacizumab reveals a TGF-β signature predictive of response in HER2-negative breast cancers

Author

Varadan, Vinay, primary, Kamalakaran, Sitharthan, additional, Gilmore, Hannah, additional, Banerjee, Nilanjana, additional, Janevski, Angel, additional, Miskimen, Kristy L.S., additional, Williams, Nicole, additional, Basavanhalli, Ajay, additional, Madabhushi, Anant, additional, Lezon-Geyda, Kimberly, additional, Bossuyt, Veerle, additional, Lannin, Donald R., additional, Abu-Khalaf, Maysa, additional, Sikov, William, additional, Dimitrova, Nevenka, additional, and Harris, Lyndsay N., additional

Published
2015
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106. Abstract PD3-4: Reliability of whole exome sequencing for assessing intratumor heterogeneity from breast tumor biopsies

Author

Shi, Weiwei, primary, Chagpar, Anees, additional, Jiang, Tingting, additional, Lannin, Donald R, additional, Killelea, Brigid, additional, Horowitz, Nina, additional, Lim, Raymond, additional, Platt, James, additional, Ng, Charlotte KY, additional, Wali, Vikram B, additional, Weigelt, Britta, additional, Reis-Filho, Jorge S, additional, Hatzis, Christos, additional, and Pusztai, Lajos, additional

Published
2015
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113. Impact of Financial Burden of Cancer on Survivors' Quality of Life

Author

Fenn, Kathleen M., primary, Evans, Suzanne B., additional, McCorkle, Ruth, additional, DiGiovanna, Michael P., additional, Pusztai, Lajos, additional, Sanft, Tara, additional, Hofstatter, Erin W., additional, Killelea, Brigid K., additional, Knobf, M. Tish, additional, Lannin, Donald R., additional, Abu-Khalaf, Maysa, additional, Horowitz, Nina R., additional, and Chagpar, Anees B., additional

Published
2014
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126. Multicenter phase II trial of neoadjuvant carboplatin, weekly nab-paclitaxel, and trastuzumab in stage II-III HER2+ breast cancer: A BrUOG study.

Author

Sinclair, Natalie Faye, primary, Sakr, Bachir Joseph, additional, Abu-Khalaf, Maysa M., additional, Somlo, George, additional, Black, Robert C, additional, Chung, Gina G., additional, Rizack, Tina, additional, Strenger, Rochelle, additional, Fenton, Mary Anne, additional, DiGiovanna, Michael, additional, Constantinou, Maria, additional, Lannin, Donald R., additional, Legare, Robert Duffy, additional, Chagpar, Anees B., additional, Sambandam, Sundaresan T., additional, Bossuyt, Veerle, additional, Rosati, Kayla, additional, Harris, Lyndsay, additional, and Sikov, William M., additional

Published
2013
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128. Brief-exposure to preoperative bevacizumab reveals a TGF-b signature predictive of response in HER2-negative breast cancers.

Author

Varadan, Vinay, Kamalakaran, Sitharthan, Gilmore, Hannah, Banerjee, Nilanjana, Janevski, Angel, Miskimen, Kristy L.S., Williams, Nicole, Basavanhalli, Ajay, Madabhushi, Anant, Lezon‐Geyda, Kimberly, Bossuyt, Veerle, Lannin, Donald R., Abu‐Khalaf, Maysa, Sikov, William, Dimitrova, Nevenka, and Harris, Lyndsay N.

Abstract

To best define biomarkers of response, and to shed insight on mechanism of action of certain clinically important agents for early breast cancer, we used a brief-exposure paradigm in the preoperative setting to study transcriptional changes in patient tumors that occur with one dose of therapy prior to combination chemotherapy. Tumor biopsies from breast cancer patients enrolled in two preoperative clinical trials were obtained at baseline and after one dose of bevacizumab (HER2-negative), trastuzumab (HER2-positive) or nab-paclitaxel, followed by treatment with combination chemo-biologic therapy. RNA-Sequencing based PAM50 subtyping at baseline of 46 HER2-negative patients revealed a strong association between the basal-like subtype and pathologic complete response (pCR) to chemotherapy plus bevacizumab (p≤0.0027), but did not provide sufficient specificity to predict response. However, a single dose of bevacizumab resulted in down-regulation of a well-characterized TGF-β activity signature in every single breast tumor that achieved pCR (p≤0.004). The TGF-β signature was confirmed to be a tumor-specific read-out of the canonical TGF-β pathway using pSMAD2 (p≤0.04), with predictive power unique to briefexposure to bevacizumab (p ≤ 0.016), but not trastuzumab or nab-paclitaxel. Down-regulation of TGF-β activity was associated with reduction in tumor hypoxia by transcription and protein levels, suggesting therapy-induced disruption of an autocrineloop between tumor stroma and malignant cells. Modulation of the TGF-β pathway upon brief-exposure to bevacizumab may provide an early functional readout of pCR to preoperative anti-angiogenic therapy in HER2-negative breast cancer, thus providing additional avenues for exploration in both preclinical and clinical settings with these agents. [ABSTRACT FROM AUTHOR]

Published
2016
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137. Cytoplasmic Estrogen Receptor in Breast Cancer

Author

Welsh, Allison W., primary, Lannin, Donald R., additional, Young, Gregory S., additional, Sherman, Mark E., additional, Figueroa, Jonine D., additional, Henry, N. Lynn, additional, Ryden, Lisa, additional, Kim, Chungyeul, additional, Love, Richard R., additional, Schiff, Rachel, additional, and Rimm, David L., additional

Published
2012
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141. Culturally Based Intervention for Breast Cancer in Rural African Americans

Author

EAST CAROLINA UNIV GREENVILLE NC, Lannin, Donald R., EAST CAROLINA UNIV GREENVILLE NC, and Lannin, Donald R.

Abstract

The purpose of this project is to develop methods to encourage earlier detection of breast cancer in rural African Americans. Our focus is on cultural and psychosocial beliefs that contribute to patient delay in seeking treatment for the symptoms of breast cancer. For the intervention phase, educational programs featuring a documentary video, public service announcements, and culturally sensitive brochures have been presented to over 2100 people in Pitt County. The final phase of the project involved post intervention surveys of women in both Pitt and Wilson Counties. Over 1400 surveys were completed and data analysis is currently underway.

Published
2001

142. Culturally Based Intervention for Breast Cancer in Rural African Americans

Author

EAST CAROLINA UNIV GREENVILLE NC, Lannin, Donald R., EAST CAROLINA UNIV GREENVILLE NC, and Lannin, Donald R.

Abstract

The purpose of this project is to develop methods to encourage earlier detection of breast cancer in rural African Americans. Our focus is on cultural and psychosocial beliefs that contribute to patient delay in seeking treatment of the symptoms of breast cancer. For the intervention phase, educational programs featuring a documentary video, public service announcements, and culturally sensitive brochures have been presented to over 1700 people in Pitt County. A separate component of the intervention involved distributing breast cancer educational packets to older female relatives of patients who visited their OB/GYN physicians and to women who were waiting for relatives in the emergency department. This older group is facing greater risk, yet may not be receiving regular breast screening. The next phase of the project will involve post-intervention surveys of women in both Pitt and Wilson Counties.

Published
2000

144. Use of neoadjuvant chemotherapy for patients with stage I to III breast cancer in the United States.

Author

Mougalian, Sarah S., Soulos, Pamela R., Killelea, Brigid K., Lannin, Donald R., Abu‐Khalaf, Maysa M., DiGiovanna, Michael P., Sanft, Tara B., Pusztai, Lajos, Gross, Cary P., and Chagpar, Anees B.

Subjects
BREAST cancer chemotherapy, ADJUVANT treatment of cancer, CANCER invasiveness, MASTECTOMY, CANCER radiotherapy, AMERICAN women, HEALTH, CANCER risk factors
Abstract

BACKGROUND Neoadjuvant chemotherapy (NAC) is the standard of care for patients with locally advanced breast cancer and can yield clinical advantages in individuals with lower stage cancers as well. To the authors' knowledge, the extent and patterns of use of NAC remain unknown. The objective of the current study was to assess temporal trends in NAC use and to examine what clinical, demographic, and treatment site characteristics influence its use. METHODS Data from the National Cancer Data Base regarding 395,486 patients with stage I to stage III breast cancer who received adjuvant or neoadjuvant chemotherapy in the United States from 2003 through 2011 were analyzed. Chi-square tests and logistic regression analyses were used to assess the association between NAC use and patient, tumor, and facility characteristics. RESULTS Overall, 17.4% of patients received NAC, including 4% of patients with stage I disease, 17.8% of patients with stage II disease, and 41.6% of patients with stage III disease. NAC use increased over time from 12.2% to 24.0%, particularly among patients with more advanced cancers. Rates increased from 12.9% to 39.3% in patients with stage IIIA, from 72.3% to 86.4% in patients with stage IIIB, and from 30.1% to 59.3% in patients with stage IIIC cancers. On multivariate analysis, patients aged <60 years, African American individuals, and those treated in academic centers were more likely to receive NAC. NAC use also varied by geographic region and was the highest in the West South Central region (21%) and lowest in the Midwest (15.2%). CONCLUSIONS Although NAC use increased between 2003 and 2011, <50% of all patients with stage III breast cancer were treated with NAC. Substantial regional and practice-related variations exist. Cancer 2015;121:2544-2552. © 2015 American Cancer Society. [ABSTRACT FROM AUTHOR]

Published
2015
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145. Characteristics of Multifocal and Multicentric Breast Cancers.

Author

Kanumuri, Prathima, Hayse, Brandon, Killelea, Brigid, Chagpar, Anees, Horowitz, Nina, and Lannin, Donald

Abstract

Background: Multifocality and multicentricity are increasingly recognized in breast cancer. However, little is known about the characteristics and biology of these cancers and the clinical implications are controversial. Methods: A retrospective, institutional database was used to compare characteristics of multifocal (MF) and multicentric (MC) breast cancers with unifocal (UF) cancers to study concordance of histology and receptor status among primary and secondary foci and to evaluate predictors of lymph node positivity using multivariate logistic regression. Results: Of 1495 invasive cancers, 1231 (82.3 %) were UF, 169 (11.3 %) were MF, and 95 (6.4 %) were MC cancers. When MF and MC cancers were compared with UF cancers, MC but not MF cancers were associated with young age at diagnosis, larger tumor size, lymphovascular invasion, and node positivity. MF but not MC tumors were more likely to be ER/PR+Her2+ tumors and less likely to be triple-negative cancers compared with UF tumors. MF tumors were more likely to be infiltrating ductal carcinomas with an extensive intraductal component, and MC tumors were more likely to be infiltrating lobular carcinomas. Concordance of histology and receptor status between primary and secondary foci was high and was similar for both MF and MC cancers. Multicentricity remained an independent predictor of lymph node positivity on multivariate analysis. Conclusion: MF and MC tumors seem to be biologically different diseases. MC is clinicopathologically more aggressive than MF disease and is more frequently associated with younger age and larger tumor size and also is an independent predictor of node positivity. [ABSTRACT FROM AUTHOR]

Published
2015
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146. Culturally Based Intervention for Breast Cancer in Rural African Americans

Author

EAST CAROLINA UNIV GREENVILLE NC, Lannin, Donald, EAST CAROLINA UNIV GREENVILLE NC, and Lannin, Donald

Abstract

The purpose of this project is to develop methods to encourage earlier detection of breast cancer in rural African Americans. Our focus is on cultural and psychosocial beliefs that contribute to patient delay in seeking treatment for the symptoms of breast cancer. For the intervention phase, educational programs featuring a documentary video, public service announcements, and culturally sensitive brochures have been presented to over 1000 people in Pitt County. A separate component of the intervention involves distributing breast cancer educational packets to older female relatives of patients who visit their OB/GYN physicians. This older group is facing greater risk, yet may not be receiving regular breast screening. The next phase of the project will involve post- intervention surveys of women in both Pitt and Wilson Counties.

Published
1999

150. Culturally Based Intervention for Breast Cancer in Rural African Americans.

Author

EAST CAROLINA UNIV GREENVILLE NC, Lannin, Donald R., EAST CAROLINA UNIV GREENVILLE NC, and Lannin, Donald R.

Abstract

The purpose of this project is to develop methods to encourage earlier detection of breast cancer in rural African Americans. Our focus is on cultural and psychosocial beliefs which contribute to patient delay in seeking treatment for the symptoms of breast cancer. A comprehensive pre-intervention survey has been completed involving almost 1200 women in 2 rural counties in eastern North Carolina. The results of this survey confirm our previous work that there is a high prevalence of certain beliefs which we have previously shown to be associated with advanced stage breast cancer. These beliefs are significantly more prevalent among African American women. The next phase of the project involves educational interventions to attempt to change some of these beliefs. A documentary video, public service announcements, brochures, and other educational materials have been developed and the intervention has just been initiated. A kick-off symposium timed to coincide with breast cancer awareness month is being held on October 6, 1998.

Published
1998

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