2,957 results on '"Lamberti, P."'
Search Results
102. Host nasopharyngeal transcriptome dataset of a SARS-CoV-2 positive Italian cohort
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Salvati, Annamaria, Ferravante, Carlo, Lamberti, Jessica, Rocco, Teresa, Alexandrova, Elena, D’Agostino, Ylenia, Sorokin, Maksim, Efimov, Victor, Buzdin, Anton, Strianese, Oriana, Nassa, Giovanni, Tarallo, Roberta, Weisz, Alessandro, Rizzo, Francesca, and Giurato, Giorgio
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- 2023
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103. Impact of TMB/PD-L1 expression and pneumonitis on chemoradiation and durvalumab response in stage III NSCLC
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Alessi, Joao V., Ricciuti, Biagio, Wang, Xinan, Pecci, Federica, Di Federico, Alessandro, Lamberti, Giuseppe, Elkrief, Arielle, Rodig, Scott J., Lebow, Emily S., Eicholz, Jordan E., Thor, Maria, Rimner, Andreas, Schoenfeld, Adam J., Chaft, Jamie E., Johnson, Bruce E., Gomez, Daniel R., Awad, Mark M., and Shaverdian, Narek
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- 2023
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104. Scalable and highly selective graphene-based ion-exchange membranes with tunable permselectivity
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Aixalà-Perelló, Anna, Pedico, Alessandro, Laurenti, Marco, Fontananova, Enrica, Bocchini, Sergio, Ferrari, Ivan Vito, and Lamberti, Andrea
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- 2023
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105. Pasteurization of human milk affects the miRNA cargo of EVs decreasing its immunomodulatory activity
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Torrez Lamberti, Monica F., Parker, Leslie A., Gonzalez, Claudio F., and Lorca, Graciela L.
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- 2023
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106. Appendiceal goblet cell carcinoma has marginal advantages from perioperative chemotherapy: a population-based study with an entropy balancing analysis
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Ricci, Claudio, Campana, Davide, Ingaldi, Carlo, Lamberti, Giuseppe, Alberici, Laura, Tateo, Valentina, Castagna, Giovanni, Ricco, Gianluca, Calderaro, Fulvio, Malvi, Deborah, Rosini, Francesca, and Casadei, Riccardo
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- 2023
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107. Traditional versus progressive robot-assisted gait training in people with multiple sclerosis and severe gait disability: study protocol for the PROGR-EX randomised controlled trial
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Michela Rimondini, Fabio Manfredini, Andrea Baroni, Sofia Straudi, Nicola Lamberti, Marialuisa Gandolfi, Valeria Bertagnolo, Silvia Grassilli, and Luigi Zerbinati
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Medicine (General) ,R5-920 - Abstract
Gait disorders are the most frequent symptoms associated to multiple sclerosis (MS). Robot-assisted gait training (RAGT) in people with MS (PwMS) has been proposed as a possible effective treatment option for severe motor disability without significant superiority when compared to intensive overground gait training (OGT). Furthermore, RAGT at high intensity may enhance fatigue and spasticity. This study aims to evaluate the effects of a low-intensity RAGT at progressively increasing intensity compared to conventional RAGT and OGT in PwMS and moderate to severe walking impairment. 24 PwMS will be recruited and assigned to one of the three treatment groups: low-intensity RAGT at progressively increasing intensity, conventional RAGT and OGT. All participants will receive 3-weekly treatment sessions of 3 hours each for 4 weeks. In the first 2 hours of treatment, all participants will receive a rehabilitation programme based on stretching exercises, muscle strengthening and educational interventions. During the last hour, subjects will undergo specific gait training according to the assignment group. Outcomes will be assessed before and after treatment and at 3-month follow-up. The primary outcome is walking speed. Secondary outcomes include mobility and balance, psychological measures, muscle oxygen consumption, electrical and haemodynamic brain activity, urinary biomarkers, usability, and acceptability of robotic devices for motor rehabilitation. The results of this study will provide a safe, affordable and non-operator-dependent, intervention for PwMS. Results in terms of functional, psychological, neurophysiological and biological outcomes will confirm our hypothesis. The study’s trial registration number: NCT06381440.
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- 2024
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108. Checkpoint Inhibitor Monotherapy in Potentially Trial-Eligible or Trial-Ineligible Patients With Metastatic NSCLC in the German Prospective CRISP Registry Real-World Cohort (AIO-TRK-0315)
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Frank Griesinger, MD, PhD, Wilfried E.E. Eberhardt, MD, PhD, Wolfgang M. Brueckl, MD, PhD, Horst-Dieter Hummel, MD, PhD, Bastian Jaeschke, MD, Jens Kern, MD, Claas Wesseler, MD, Martina Jänicke, PdD, Annette Fleitz, PhD, Stefan Zacharias, PhD, Annette Hipper, PhD, Annika Groth, MD, PhD, Wilko Weichert, MD, PhD, Steffen Dörfel, Volker Petersen, MD, Jan Schröder, MD, Jochen Wilke, MD, Martin Sebastian, MD, Michael Thomas, MD, PhD, Juliana Ababei, Jürgen Alt, Andreas Ammon, Jürgen Anhuf, Ivo Azeh, Stefan Bauer, Dirk Behringer, Winfried Berger, Christiane Bernhardt, Mathias Bertram, Michael Boesche, Sabine Bohnet, Harald-Robert Bruch, Wolfgang Brückl, Ulrike Burkhard-Meier, Petros Christopoulos, Klaus-Ulrich Däßler, Maike de Wit, Tobias Dechow, Reinhard Depenbusch, Lutz Dietze, Markus Dommach, Wilfried Eberhardt, Corinna Elender, Wolfgang Elsel, Till-Oliver Emde, Martin Faehling, Thomas Fietz, Jürgen R. Fischer, Dimitri Flieger, Anke Freidt, Werner Freier, Christian Frenzel, Florian Fuchs, Roswitha Fuchs, Tobias Gaska, Wolfgang Gleiber, Christian Grah, Frank Griesinger, Christian Grohé, Matthias Groschek, Björn Güldenzoph, Andreas Günther, Siegfried Haas, Matthias Hackenthal, Volker Hagen, Lars Hahn, Verena Hannig Carla, Richard Hansen, Hanns-Detlev Harich, Monika Heilmann, Kathrin Heinrich, Christiane Hering-Schubert, Jörg Heßling, Petra Hoffknecht, Patricia Hortig, Gerdt Hübner, Horst-Dieter Hummel, Ulrich Hutzschenreuter, Thomas Illmer, Georg Innig, Bastian Jaeschke, Christian Junghanß, Ulrich Kaiser, Haytham Kamal, Kato Kambartel, Jens Kern, Martin Kimmich, Dorothea Kingreen, Heinz Kirchen, Martine Klausmann, Ortwin Klein, Konrad Kokowski, Wolfgang Körber, Cornelius Kortsik, Dirk Koschel, Benoit Krämer, Beate Krammer-Steiner, Eckart Laack, Christof Lamberti, Rumo David Leistner, Christoph Losem, Andreas Lück, Christoph Maintz, Kerstin Martin, Dirk Medgenberg, Martin Metzenmacher, Christian Meyer zum Büschenfelde, Philipp Meyn, Enno Moorahrend, Annette Müller, Lothar Müller, Michael Neise, Holger Nückel, Arnd Nusch, Tobias Overbeck, Henning Pelz, Volker Petersen, Bettina Peuser, Margarete Plath, Winfried J. Randerath, Jacqueline Rauh, Martin Reck, Dietmar Reichert, Niels Reinmuth, Marcel Reiser, Roland Repp, Daniel Reschke, Achim Rittmeyer, Yolanda Rodemer, Sandra Sackmann, Parvis Sadjadian, Reiner Sandner, Annette Sauer, Harald Schäfer, Christoph Schaudt, Rudolf Schlag, Burkhard Schmidt, Stephan Schmitz, Jan Schröder, Michael Schroeder, Mathias Schulze, Christian Schumann, Wolfgang Schütte, Martin Schwaiblmair, Florian Schwindt Peter, Martin Sebastian, Bernd Seese, Gernot Seipelt, Thomas Sorgenfrei, Johannes Steiff, Heike Steiniger, Tanja Trarbach, Amanda Tufman, Jens Uhlig, Ursula Vehling-Kaiser, Eyck von der Heyde, Ulla von Verschuer, Cornelius Waller, Thomas Wehler, Georg Weißenborn, Florian Weißinger, Martin Wermke, Claas Wesseler, Jörg Wiegand, Stefan Wilhelm, Jochen Wilke, Mark-Oliver Zahn, Matthias Zaiss, and Matthias Zeth
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Non–small cell lung carcinoma ,Prospective studies ,Immune checkpoint inhibitors ,Pembrolizumab ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Introduction: Patients with metastatic NSCLC (mNSCLC) treated with immune checkpoint inhibitors in clinical practice may often not meet the strict inclusion criteria of clinical trials. Our aim was to assess the trial eligibility of patients with mNSCLC treated with pembrolizumab monotherapy in real-world and to compare the outcome of “trial-ineligible” and “potentially trial-eligible” patients. Methods: Data from the prospective, clinical research platform CRISP were used to compare patient characteristics, treatment, and outcome of patients with programmed cell death-ligand 1 tumor proportion score greater than or equal to 50% tumors treated with pembrolizumab monotherapy who are deemed either “potentially trial-eligible” or “trial-ineligible” according to inclusion and exclusion criteria of the registrational studies (KEYNOTE-024 and -042). Results: Of 746 patients included, 343 patients (46.0%) were classified as “trial-ineligible” and had significantly worse outcomes compared with “potentially trial-eligible” patients (n = 403, 54.0%): median progression-free survival: 6.2 (95% confidence interval [CI]: 5.2–8.4) versus 10.3 (95% CI: 8.4–13.8) months, hazard ratio (trial-ineligible versus potentially trial-eligible) of 1.43 (95% CI: 1.19–1.72), p less than 0.001; median overall survival: 15.9 (95% CI: 11.4–20.3) versus 25.3 (95% CI: 19.8–30.4) months, hazard ratio of 1.36 (95% CI: 1.10–1.67), p equals 0.004. Conclusions: Our data reveal that a considerable proportion of patients with mNSCLC are not eligible to participate in a clinical trial and were found to have worse outcomes than potentially trial-eligible patients, whose outcomes were comparable with those obtained from pivotal clinical trials. This is of substantial clinical relevance for physicians discussing outcomes to be expected with their patients and stresses the need for real-world effectiveness analyses.
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- 2024
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109. Evidence-informed and consensus-based statements about SAFEty of Physical Agent Modalities Practice in physiotherapy and rehabilitation medicine (SAFE PAMP): a national Delphi of healthcare scientific societies
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Fabio Bandini, Giacomo Rossettini, Stefano Vercelli, Roberto Bortolotti, Silvia Gianola, Silvia Bargeri, Andrea Turolla, Greta Castellini, Simone Cecchetto, Bianca Masturzo, Leonardo Pellicciari, Anna Fulvio, Vincenzo Genovese, Matteo Benedini, Emanuele Proverbio, Simone Gambazza, Chiara Torresetti, Carla Berliri, Mauro Roselli, Marco Scorcu, Giuseppe Botta, Luigi Nappi, Gianmarco Rea, Enrico Marinelli, Viviana Rosati, Armando Perrotta, Gianfranco Lamberti, Monica Pierattelli, and Giancarlo Tancredi
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Medicine - Abstract
Objective A shared consensus on the safety about physical agent modalities (PAMs) practice in physiotherapy and rehabilitation is lacking. We aimed to develop evidence-informed and consensus-based statements about the safety of PAMs.Study design and setting A RAND-modified Delphi Rounds’ survey was used to reach a consensus. We established a steering committee of the Italian Association of Physiotherapy (Associazione Italiana di Fisioterapia) to identify areas and questions for developing statements about the safety of the most commonly used PAMs in physiotherapy and rehabilitation. We invited 28 National Scientific and Technical Societies, including forensics and lay members, as a multidisciplinary and multiprofessional panel of experts to evaluate the nine proposed statements and formulate additional inputs. The level of agreement was measured using a 9-point Likert scale, with consensus in the Delphi Rounds assessed using the rating proportion with a threshold of 75%.Results Overall, 17 (61%) out of 28 scientific and technical societies participated, involving their most representative members. The panel of experts mainly consisted of clinicians (88%) with expertise in musculoskeletal (47%), pelvic floor (24%), neurological (18%) and lymphatic (6%) disorders with a median experience of 30 years (IQR=17–36). Two Delphi rounds were necessary to reach a consensus. The final approved criteria list comprised nine statements about the safety of nine PAMs (ie, electrical stimulation neuromodulation, extracorporeal shock wave therapy, laser therapy, electromagnetic therapy, diathermy, hot thermal agents, cryotherapy and therapeutic ultrasound) in adult patients with a general note about populations subgroups.Conclusions The resulting consensus-based statements inform patients, healthcare professionals and policy-makers regarding the safe application of PAMs in physiotherapy and rehabilitation practice. Future research is needed to extend this consensus on paediatric and frail populations, such as immunocompromised patients.
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- 2024
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110. Co-detection of azoxystrobin and thiabendazole fungicides in mold and mildew resistant wallboards and in children
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Wenxin Hu, Yun-Chung Hsiao, Nikolas Morrison-Welch, Sophia Lamberti, Chih-Wei Liu, Weili Lin, Stephanie M. Engel, Kun Lu, and Mark J. Zylka
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Azoxystrobin ,Thiabendazole ,Wallboard ,Exposure pathway ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
The study measured the levels of azoxystrobin (AZ) and thiabendazole (TBZ) in wallboards and metabolite levels of these fungicides in children. The paper covering of wallboard samples contained a higher concentration of AZ and TBZ than the gypsum core, and similar amounts (w/w) of these two fungicides were present in the samples. These data suggest that commercial products containing a 1:1 (w/w) amount of AZ and TBZ, such as Sporgard® WB or Azo Tech™, were applied to the wallboard paper. This is the first detection of TBZ in mold-and-mildew resistant wallboards. The TBZ metabolite, 5OH-TBZ, was detected in 48% of urine samples collected from children aged 40–84 months, and was co-detected with AZ-acid, a common AZ metabolite, in 37.5% of the urine samples. The detection frequency of 5OH-TBZ was positively associated with the detection frequency of AZ-acid. These findings suggest that certain types of wallboards used in homes and commercial buildings may be a potential source of co-exposure to AZ and TBZ in humans.
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- 2024
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111. Protocol for functional profiling of patient-derived organoids for precision oncology
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Niloofar Nemati, Nina Boeck, Giorgia Lamberti, Rebecca Lisandrelli, and Zlatko Trajanoski
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Cancer ,Sequencing ,RNAseq ,Organoids ,Systems biology ,Science (General) ,Q1-390 - Abstract
Summary: Functional precision oncology—a strategy based on perturbing primary tumor cells from cancer patients—could provide a road forward for personalized treatment. Here, we present a comprehensive protocol covering generation and culture of patient-derived colorectal organoids, isolation and expansion of tumor-infiltrating lymphocytes (TILs), and isolation and culture of peripheral blood mononuclear cells (PBMCs). With this protocol, samples fulfilling the demands for performing multi-omics analysis, e.g., RNA sequencing (RNA-seq), whole-exome sequencing (WES), single-cell RNA sequencing (scRNA-seq), and (phospho-)proteomics, can be generated.For complete details on the use and execution of this protocol, please refer to Plattner et al. (2023).1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
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- 2024
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112. Acute effects of slow, controlled breathing exercises on arterial pressure and autonomic cardiac modulation in hypertensive patients
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Léo José Rubin Neto, Gustavo Orione Puntel, Dhayan Quevedo Ferrão, Mireli Hemann Lamberti, Bruno Cesar Correa Arbiza, Katieli Santos de Lima, Antônio Marcos Vargas da Silva, and Luis Ulisses Signori
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Medicine (General) ,R5-920 - Abstract
The aim of the present study was to evaluate the influence of slow, controlled breathing exercises (SCBE) on arterial pressure and autonomic cardiac modulation in hypertensive patients. 29 hypertensive patients were evaluation in two data collections (period between 1 to 3 days). In each evaluation, data were collected after 10 min of spontaneous breathing (between 12 and 20 breaths per minute – bpm) and 10 min of SCBE (12 bpm, in the rhythm of standardized verbal stimulus). The arterial pressure was evaluated by a multi-parameter monitor and the autonomic cardiac modulation by the rate variability technique. The SCBE reduced systolic arterial pressure (1st evaluation: -4.8 mmHg and 2nd evaluation: -4.3 mmHg), decreased sympathetic activity by 18% and modified autonomic modulation by about 50%. SCBE reduced both systolic arterial pressure and sympathetic activity and can be used in control arterial pressure of hypertensive patients.
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- 2024
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113. Real-time sensing with multiplexed optomechanical resonators
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Lamberti, Fabrice, Palanchoke, Ujwol, Geurts, Thijs, Gely, Marc, Regord, Sebastien, Banniard, Louise, Sansa, Marc, Favero, Ivan, Jourdan, Guillaume, and Hentz, Sebastien
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Physics - Applied Physics ,Physics - Optics - Abstract
Nanoelectromechanical resonators have been successfully used for a variety of sensing applications. Their extreme resolution comes from their small size at the cost of low capture area, making the "needle in a haystack" issue acute. This leads to poor instrument sensitivity and long analysis time. Moreover, electrical transductions are limited in frequency, which limits the achievable mechanical bandwidth again limiting throughput. Multiplexing a large number of high-frequency resonators appears as a solution, but this is complex with electrical transductions. We propose here a route to solve these issues, with a multiplexing scheme for very high frequency optomechanical resonators. We demonstrate the simultaneous frequency measurement of three silicon microdisks resonators fabricated through a Very Large Scale Integration process. The readout architecture is simple and does not degrade the sensing resolutions. This paves the way towards the realization of sensors for multi-parametric analysis, extremely low limit of detection and response time.
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- 2021
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114. Faster-LTN: a neuro-symbolic, end-to-end object detection architecture
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Manigrasso, Francesco, Miro, Filomeno Davide, Morra, Lia, and Lamberti, Fabrizio
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Logic in Computer Science - Abstract
The detection of semantic relationships between objects represented in an image is one of the fundamental challenges in image interpretation. Neural-Symbolic techniques, such as Logic Tensor Networks (LTNs), allow the combination of semantic knowledge representation and reasoning with the ability to efficiently learn from examples typical of neural networks. We here propose Faster-LTN, an object detector composed of a convolutional backbone and an LTN. To the best of our knowledge, this is the first attempt to combine both frameworks in an end-to-end training setting. This architecture is trained by optimizing a grounded theory which combines labelled examples with prior knowledge, in the form of logical axioms. Experimental comparisons show competitive performance with respect to the traditional Faster R-CNN architecture., Comment: accepted for presentation at ICANN 2021
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- 2021
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115. Fecal Incontinence after Severe Brain Injury: A Barrier to Discharge after Inpatient Rehabilitation?
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Laura Pelizzari, Elena Antoniono, Donatella Giraudo, Gianluca Ciardi, and Gianfranco Lamberti
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fecal incontinence ,brain injuries ,rehabilitation outcome ,Medicine ,Internal medicine ,RC31-1245 ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background: In this study, we aimed to investigate the incidence of fecal incontinence (FI) after severe acquired brain injuries (sABIs) and to determine whether this symptom can lead to an inability to return home after rehabilitation. Methods: This was a retrospective observational cohort study. In total, 521 acute sABI inpatients were enrolled from the Department of Neurorehabilitation at an academic tertiary care hospital. Patients were divided into two groups, with and without FI, at the end of the rehabilitation phase. The primary and secondary endpoints were the incidence of persistent FI and any difference in the discharge destination. Results: Upon admission, new-onset FI was found in 443 (85%) patients, of which 38% had traumatic sABI. Moreover, 62.7% of all patients had FI upon admission. At discharge, 53.3% (264/495) of patients still had FI. Of these, 75.4% (199/264) had a Rancho Level of Cognitive Functioning Scale (LCFS) ≥3. A statistically significant correlation between FI at discharge and the presence of frontal lesions, autonomic crises, and increased LCFS scores was noted. Among the patients discharged to their homes, the proportion with persistent FI was lower (34% vs. 53.3). Conclusions: FI was significantly persistent after sABI, even after recovery from unconsciousness, and must be considered as a consequence of, rather than an independent risk factor for, unfavorable outcomes.
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- 2023
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116. Rehabilitation Outcome Measures in Patients with Spinal Stenosis: A Literary Review
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Gianluca Ciardi, Gianfranco Lamberti, Vittorio Casati, and Elena Paris
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lumbar spinal stenosis ,rehabilitation ,outcome measures ,disability ,quality of life ,clinical tests ,Physiology ,QP1-981 - Abstract
Background: Lumbar spinal stenosis causes considerable disability in everyday life; its incidence is increasing due to aging in the world population. First-line treatment is generally conservative, but rehabilitation outcome is still unclear; the aim of this systematic review was to define which domains need to be evaluated for the lumbar stenosis physiotherapy approach, further specifying if the literature suggests patient-centred or objective measures. Methods: A systematic review of the literature according to the PRISMA statement was carried out; the PICO model was used to draw research questions. RCTs about the rehabilitation of lumbar spinal stenosis conducted in the last five years were considered includible, with no difference in terms of stenosis location. The following databases were screened through specific search strings: PubMed, EBSCO, PEDro, Cochrane Database, Scopus, and Google Scholar; two independent researchers assessed results and a third opinion was requested to solve conflicts. Critical appraisal of the included studies was conducted through Pedro Jadad scores. The following data were extracted: author and year, country, sample, intervention, outcome domains, and tools. Results: From 10,069 records, three RCTs were included in the final review stage; they all showed high methodological quality. It is recommended for physiotherapists dealing with lumbar spinal stenosis to assess five main domains: disability, pain, clinical tests, mental wellbeing and kynesiophobia, and quality of life. Domains were mainly assessed through self-reported questionnaires/scales, while objective tests evaluate general lower limb movements, the active range of motion, or the muscles’ endurance. Conclusion: This five-domain evaluation model is reliable and can be practised in each rehabilitation setting (home, outpatient, and hospital); sustainability is guaranteed by the prevalent employment of self-reported tools. Future studies should evaluate the best questionnaire/scale for each domain, especially the definition of a gold standard for pain assessment in patients with lumbar stenosis as this is a challenge for the future.
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- 2023
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117. An Update on Appendiceal Neuroendocrine Tumors
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Andrini, Elisa, Lamberti, Giuseppe, Alberici, Laura, Ricci, Claudio, and Campana, Davide
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- 2023
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118. Resistance to KRAS G12C Inhibition in Non-small Cell Lung Cancer
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Di Federico, Alessandro, Ricciotti, Ilaria, Favorito, Valentina, Michelina, Sandra Vietti, Scaparone, Pietro, Metro, Giulio, De Giglio, Andrea, Pecci, Federica, Lamberti, Giuseppe, Ambrogio, Chiara, and Ricciuti, Biagio
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- 2023
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119. Peripheral nervous system adverse events associated with immune checkpoint inhibitors
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Rossi, Simone, Gelsomino, Francesco, Rinaldi, Rita, Muccioli, Lorenzo, Comito, Francesca, Di Federico, Alessandro, De Giglio, Andrea, Lamberti, Giuseppe, Andrini, Elisa, Mollica, Veronica, D’Angelo, Roberto, Baccari, Flavia, Zenesini, Corrado, Madia, Pierandrea, Raschi, Emanuel, Cortelli, Pietro, Ardizzoni, Andrea, and Guarino, Maria
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- 2023
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120. Experimental investigation of the influence of wire offset and composition on complex profile WEDM of Ti6Al4V using trim-pass strategy
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Rehan, Muhammad, Khan, Sarmad Ali, Naveed, Rakhshanda, Usman, Muhammad, Anwar, Saqib, AlFaify, Abdullah Yahia, Pruncu, Catalin Iulian, and Lamberti, Luciano
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- 2023
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121. Crude dry extract from Colocasia esculenta in association with poly(vinyl alcohol) as biomaterial to prepare bioactive wound dressing
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de Prado, Elisabeth Maria López, de Paula, Geanne Aparecida, Dutra, Jessyca Aparecida Paes, Cipriano, Daniel Fernandes, Kitagawa, Rodrigo Rezende, Siman, Fabiana Dayse Magalhães, Meira, Eduardo Frizzera, de Freitas, Jair Carlos Checon, Severi, Juliana Aparecida, Carreira, Lílian Gasparelli, Oréfice, Rodrigo Lamberti, and Villanova, Janaina Cecília Oliveira
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- 2023
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122. Breast Mass Detection with Faster R-CNN: On the Feasibility of Learning from Noisy Annotations
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Famouri, Sina, Morra, Lia, Mangia, Leonardo, and Lamberti, Fabrizio
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Computer Science - Computer Vision and Pattern Recognition ,Physics - Medical Physics - Abstract
In this work we study the impact of noise on the training of object detection networks for the medical domain, and how it can be mitigated by improving the training procedure. Annotating large medical datasets for training data-hungry deep learning models is expensive and time consuming. Leveraging information that is already collected in clinical practice, in the form of text reports, bookmarks or lesion measurements would substantially reduce this cost. Obtaining precise lesion bounding boxes through automatic mining procedures, however, is difficult. We provide here a quantitative evaluation of the effect of bounding box coordinate noise on the performance of Faster R-CNN object detection networks for breast mass detection. Varying degrees of noise are simulated by randomly modifying the bounding boxes: in our experiments, bounding boxes could be enlarged up to six times the original size. The noise is injected in the CBIS-DDSM collection, a well curated public mammography dataset for which accurate lesion location is available. We show how, due to an imperfect matching between the ground truth and the network bounding box proposals, the noise is propagated during training and reduces the ability of the network to correctly classify lesions from background. When using the standard Intersection over Union criterion, the area under the FROC curve decreases by up to 9%. A novel matching criterion is proposed to improve tolerance to noise.
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- 2021
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123. Investigating Outdoor Recognition Performance of Infrared Beacons for Infrastructure-based Localization
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Kampmann, Alexandru, Lamberti, Michael, Petrovic, Nikola, Kowalewski, Stefan, and Alrifaee, Bassam
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Robotics - Abstract
This paper demonstrates a system comprised of infrared beacons and a camera equipped with an optical band-pass filter. Our system can reliably detect and identify individual beacons at 100m distance regardless of lighting conditions. We describe the camera and beacon design as well as the image processing pipeline in detail. In our experiments, we investigate and demonstrate the ability of the system to recognize our beacons in both daytime and nighttime conditions. High precision localization is a key enabler for automated vehicles but remains unsolved, despite strong recent improvements. Our low-cost, infrastructure-based approach is a potential step towards solving the localization problem. All datasets are made available here https://embedded.rwth-aachen.de/doku.php?id=forschung:mobility:infralocalization:concept., Comment: Accepted at IEEE Intelligent Vehicle 2022
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- 2021
124. Training Medical Communication Skills with Virtual Patients: Literature Review and Directions for Future Research
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Battegazzorre, Edoardo, Bottino, Andrea, and Lamberti, Fabrizio
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Computer Science - Human-Computer Interaction ,J.3 ,I.3.7 - Abstract
Effective communication is a crucial skill for healthcare providers since it leads to better patient health, satisfaction and avoids malpractice claims. In standard medical education, students' communication skills are trained with role-playing and Standardized Patients (SPs), i.e., actors. However, SPs are difficult to standardize, and are very resource consuming. Virtual Patients (VPs) are interactive computer-based systems that represent a valuable alternative to SPs. VPs are capable of portraying patients in realistic clinical scenarios and engage learners in realistic conversations. Approaching medical communication skill training with VPs has been an active research area in the last ten years. As a result, the number of works in this field has grown significantly. The objective of this work is to survey the recent literature, assessing the state of the art of this technology with a specific focus on the instructional and technical design of VP simulations. After having classified and analysed the VPs selected for our research, we identified several areas that require further investigation, and we drafted practical recommendations for VP developers on design aspects that, based on our findings, are pivotal to create novel and effective VP simulations or improve existing ones.
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- 2021
125. Spectral stability of the Steklov problem
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Ferrero, Alberto and Lamberti, Pier Domenico
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Mathematics - Analysis of PDEs - Abstract
This paper investigates the stability properties of the spectrum of the classical Steklov problem under domain perturbation. We find conditions which guarantee the spectral stability and we show their optimality. We emphasize the fact that our spectral stability results also involve convergence of eigenfunctions in a suitable sense according with the definition of connecting system by \cite{Vainikko}. The convergence of eigenfunctions can be expressed in terms of the $H^1$ strong convergence. The arguments used in our proofs are based on an appropriate definition of compact convergence of the resolvent operators associated with the Steklov problems on varying domains. In order to show the optimality of our conditions we present alternative assumptions which give rise to a degeneration of the spectrum or to a discontinuity of the spectrum in the sense that the eigenvalues converge to the eigenvalues of a limit problem which does not coincide with the Steklov problem on the limiting domain., Comment: arXiv admin note: text overlap with arXiv:2103.04202
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- 2021
126. Spectral stability for a class of fourth order Steklov problems under domain perturbations
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Ferrero, Alberto and Lamberti, Pier Domenico
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Mathematics - Analysis of PDEs - Abstract
We study the spectral stability of two fourth order Steklov problems upon domain perturbation. One of the two problems is the classical DBS - Dirichlet Biharmonic Steklov - problem, the other one is a variant. Under a comparatively weak condition on the convergence of the domains, we prove the stability of the resolvent operators for both problems, which implies the stability of eigenvalues and eigenfunctions. The stability estimates for the eigenfunctions are expressed in terms of the strong $H^2$-norms. The analysis is carried out without assuming that the domains are star-shaped. Our condition turns out to be sharp at least for the variant of the DBS problem. In the case of the DBS problem, we prove stability of a suitable Dirichlet-to-Neumann type map under very weak conditions on the convergence of the domains and we formulate an open problem. As bypass product of our analysis, we provide some stability and instability results for Navier and Navier-type boundary value problems for the biharmonic operator.
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- 2021
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127. Comparing State-of-the-Art and Emerging Augmented Reality Interfaces for Autonomous Vehicle-to-Pedestrian Communication
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Pratticò, F. Gabriele, Lamberti, Fabrizio, Cannavò, Alberto, Morra, Lia, and Montuschi, Paolo
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Computer Science - Human-Computer Interaction ,Computer Science - Artificial Intelligence ,Computer Science - Graphics - Abstract
Providing pedestrians and other vulnerable road users with a clear indication about a fully autonomous vehicle status and intentions is crucial to make them coexist. In the last few years, a variety of external interfaces have been proposed, leveraging different paradigms and technologies including vehicle-mounted devices (like LED panels), short-range on-road projections, and road infrastructure interfaces (e.g., special asphalts with embedded displays). These designs were experimented in different settings, using mockups, specially prepared vehicles, or virtual environments, with heterogeneous evaluation metrics. Promising interfaces based on Augmented Reality (AR) have been proposed too, but their usability and effectiveness have not been tested yet. This paper aims to complement such body of literature by presenting a comparison of state-of-the-art interfaces and new designs under common conditions. To this aim, an immersive Virtual Reality-based simulation was developed, recreating a well-known scenario represented by pedestrians crossing in urban environments under non-regulated conditions. A user study was then performed to investigate the various dimensions of vehicle-to-pedestrian interaction leveraging objective and subjective metrics. Even though no interface clearly stood out over all the considered dimensions, one of the AR designs achieved state-of-the-art results in terms of safety and trust, at the cost of higher cognitive effort and lower intuitiveness compared to LED panels showing anthropomorphic features. Together with rankings on the various dimensions, indications about advantages and drawbacks of the various alternatives that emerged from this study could provide important information for next developments in the field., Comment: Accepted for publication in IEEE Transactions on Vehicular Technology
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- 2021
128. Label-free DNA biosensing by topological light confinement
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Zito, Gianluigi, Sanità, Gennaro, Alulema, Bryan Guilcapi, Yépez, Sofía N Lara, Lanzio, Vittorino, Riminucci, Fabrizio, Cabrini, Stefano, Moccia, Maria, Avitabile, Concetta, Lamberti, Annalisa, Mocella, Vito, Rendina, Ivo, and Romano, Silvia
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Quantum Physics ,Physical Sciences ,Optical Physics ,Electrical and Electronic Engineering ,Nanotechnology ,Atomic ,molecular and optical physics ,Quantum physics - Abstract
Large-area and transparent all-dielectric metasurfaces sustaining photonic bound states in the continuum (BICs) provide a set of fundamental advantages for ultrasensitive biosensing. BICs bridge the gap of large effective mode volume with large experimental quality factor. Relying on the transduction mechanism of reactive sensing principle, herein, we first numerically study the potential of subwavelength confinement driven by topological decoupling from free space radiation for BIC-based biosensing. Then, we experimentally combine this capability with minimal and low-cost optical setup, applying the devised quasi-BIC resonator for PNA/DNA selective biosensing with real-time monitoring of the binding event. A sensitivity of 20 molecules per micron squared is achieved, i.e. 0.01 pg. Further enhancement can easily be envisaged, pointing out the possibility of single-molecule regime. This work aims at a precise and ultrasensitive approach for developing low-cost point-of-care tools suitable for routine disease prescreening analyses in laboratory, also adaptable to industrial production control.
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- 2021
129. Impact of Genomic Mutation on Melanoma Immune Microenvironment and IFN-1 Pathway-Driven Therapeutic Responses
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Fátima María Mentucci, Elisa Ayelén Romero Nuñez, Agustina Ercole, Valentina Silvetti, Jessica Dal Col, and María Julia Lamberti
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BRAFV600E ,IFN-1 pathway ,cGAS-STING ,immunogenic cell death ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
The BRAFV600E mutation, found in approximately 50% of melanoma cases, plays a crucial role in the activation of the MAPK/ERK signaling pathway, which promotes tumor cell proliferation. This study aimed to evaluate its impact on the melanoma immune microenvironment and therapeutic responses, particularly focusing on immunogenic cell death (ICD), a pivotal cytotoxic process triggering anti-tumor immune responses. Through comprehensive in silico analysis of the Cancer Genome Atlas data, we explored the association between the BRAFV600E mutation, immune subtype dynamics, and tumor mutation burden (TMB). Our findings revealed that the mutation correlated with a lower TMB, indicating a reduced generation of immunogenic neoantigens. Investigation into immune subtypes reveals an exacerbation of immunosuppression mechanisms in BRAFV600E-mutated tumors. To assess the response to ICD inducers, including doxorubicin and Me-ALA-based photodynamic therapy (PDT), compared to the non-ICD inducer cisplatin, we used distinct melanoma cell lines with wild-type BRAF (SK-MEL-2) and BRAFV600E mutation (SK-MEL-28, A375). We demonstrated a differential response to PDT between the WT and BRAFV600E cell lines. Further transcriptomic analysis revealed upregulation of IFNAR1, IFNAR2, and CXCL10 genes associated with the BRAFV600E mutation, suggesting their involvement in ICD. Using a gene reporter assay, we showed that PDT robustly activated the IFN-1 pathway through cGAS-STING signaling. Collectively, our results underscore the complex interplay between the BRAFV600E mutation and immune responses, suggesting a putative correlation between tumors carrying the mutation and their responsiveness to therapies inducing the IFN-1 pathway, such as the ICD inducer PDT, possibly mediated by the elevated expression of IFNAR1/2 receptors
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- 2024
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130. Enhancing Therapeutic Approaches in Glioblastoma with Pro-Oxidant Treatments and Synergistic Combinations: In Vitro Experience of Doxorubicin and Photodynamic Therapy
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Bruno Agustín Cesca, Matías Daniel Caverzan, María Julia Lamberti, and Luis Exequiel Ibarra
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photodynamic therapy ,chemotherapy ,glioblastoma ,adjuvant treatment ,oxidative therapy ,TP53 mutation ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Glioblastoma (GBM) is an aggressive brain cancer characterized by significant molecular and cellular heterogeneity, which complicates treatment efforts. Current standard therapies, including surgical resection, radiation, and temozolomide (TMZ) chemotherapy, often fail to achieve long-term remission due to tumor recurrence and resistance. A pro-oxidant environment is involved in glioma progression, with oxidative stress contributing to the genetic instability that leads to gliomagenesis. Evaluating pro-oxidant therapies in brain tumors is crucial due to their potential to selectively target and eradicate cancer cells by exploiting the elevated oxidative stress levels inherent in these malignant cells, thereby offering a novel and effective strategy for overcoming resistance to conventional therapies. This study investigates the therapeutic potential of doxorubicin (DOX) and photodynamic therapy (PDT) with Me-ALA, focusing on their effects on redox homeostasis. Basal ROS levels and antioxidant gene expression (NFE2L2, CAT, GSR) were quantitatively assessed across GBM cell lines, revealing significant variability probably linked to genetic differences. DOX and PDT treatments, both individually and in combination, were analyzed for their efficacy in inducing oxidative stress and cytotoxicity. An in silico analysis further explored the relationship between gene mutations and oxidative stress in GBM patients, providing insights into the molecular mechanisms underlying treatment responses. Our findings suggest that pro-oxidant therapies, such as DOX and PDT in combination, could selectively target GBM cells, highlighting a promising avenue for improving therapeutic outcomes in GBM.
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- 2024
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131. Variations in Cortical Oxygenation by Near-Infrared Spectroscopy According to Head Position after Acute Stroke: The Preliminary Findings of an Observational Study
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Ilaria Casetta, Anna Crepaldi, Michele Laudisi, Andrea Baroni, Jessica Gemignani, Sofia Straudi, Fabio Manfredini, and Nicola Lamberti
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stroke ,rehabilitation ,head position ,fNIRS ,Medicine - Abstract
Background: After ischemic stroke, there is no general consensus on the optimal position for the head of patients in the acute phase. This observational study aimed to measure the variations in cortical oxygenation using noninvasive functional near-infrared spectroscopy (fNIRS) at different degrees of head positioning on a bed. Methods: Consecutive ischemic stroke patients aged 18 years or older with anterior circulation ischemic stroke within 48 h of symptom onset who could safely assume different positions on a bed were included. A 48-channel fNIRS system was placed in the bilateral sensorimotor cortex. Then, the bed of each patient was moved into four consecutive positions: (1) seated (90° angle between the head and bed surface); (2) lying at 30°; (3) seated again (90°); and (4) lying flat (0°). Each position was maintained for 90 s; the test was conducted 48 h after stroke onset and after 5 ± 1 days. The variations in oxygenated hemoglobin in the global brain surface and for each hemisphere were recorded and compared. Results: Twenty-one patients were included (males, n = 11; age, 79 ± 9 years; ASPECTS, 8 ± 2). When evaluating the affected side, the median oxygenation was significantly greater in the lying-flat (0°) and 30° positions than in the 90° position (p < 0.001 for both comparisons). No significant differences between the supine position and the 30° position were found, although oxygenation was slightly lower in the 30° position than in the supine position (p = 0.063). No differences were observed when comparing recanalized and nonrecanalized patients separately or according to stroke severity. The evaluation conducted 5 days after the stroke confirmed the previous data, with a significant difference in oxygenation at 0° and 30° compared to 90°. Conclusions: This preliminary study suggested that there are no substantial differences in brain oxygenation between the lying-flat head position and the 30° laying position.
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- 2024
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132. β1600 Q.Clear Digital Reconstruction of [68Ga]Ga-DOTANOC PET/CT Improves Image Quality in NET Patients
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Martina Di Franco, Emilia Fortunati, Lucia Zanoni, Norma Bonazzi, Cristina Mosconi, Claudio Malizia, Simona Civollani, Davide Campana, Elisa Andrini, Giuseppe Lamberti, Vincenzo Allegri, Stefano Fanti, and Valentina Ambrosini
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Q.Clear ,PET/CT ,[68Ga]Ga-DOTANOC ,neuroendocrine neoplasms ,neuroendocrine tumors ,NET ,Medicine - Abstract
Background: Image reconstruction is crucial for improving overall image quality and diagnostic accuracy. Q.Clear is a novel reconstruction algorithm that reduces image noise. The aim of the present study is to assess the preferred Q.Clear β-level for digital [68Ga]Ga-DOTANOC PET/CT reconstruction vs. standard reconstruction (STD) for both overall scan and single-lesion visualization. Methods: Inclusion criteria: (1) patients with/suspected neuroendocrine tumors included in a prospective observational monocentric study between September 2019 and January 2022; (2) [68Ga]Ga-DOTANOC digital PET/CT and contrast-enhanced-CT (ceCT) performed at our center at the same time. Images were reconstructed with STD and with Q.Clear β-levels 800, 1000, and 1600. Scans were blindly reviewed by three nuclear-medicine experts: the preferred β-level reconstruction was independently chosen for the visual quality of both the overall scan and the most avid target lesion < 1 cm (t) and >1 cm (T). PET/CT results were compared to ceCT. Semiquantitative analysis was performed (STD vs. β1600) in T and t concordant at both PET/CT and ceCT. Subgroup analysis was also performed in patients presenting discordant t. Results: Overall, 52 patients were included. β1600 reconstruction was considered superior over the others for both overall scan quality and single-lesion detection in all cases. The only significantly different (p < 0.001) parameters between β1600 and STD were signal-to-noise liver ratio and standard deviation of the liver background. Lesion-dependent parameters were not significantly different in concordant T (n = 37) and t (n = 10). Among 26 discordant t, when PET was positive, all findings were confirmed as malignant. Conclusions: β1600 Q.Clear reconstruction for [68Ga]Ga-DOTANOC imaging is feasible and improves image quality for both overall and small-lesion assessment.
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- 2024
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133. To Treat or not to Treat? The Fate of Patients with Intermittent Claudication Following Different Therapeutic Options
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Elpiniki Tsolaki, Luca Traina, Caterina Savriè, Franco Guerzoni, Nicola Napoli, Roberto Manfredini, Maria Cristina Taddia, Fabio Manfredini, and Nicola Lamberti
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peripheral artery disease ,exercise ,intermittent claudication ,vascular surgery ,clinical outcomes ,survival ,hospitalizations ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Peripheral artery disease (PAD) is recognized as a significant contributor to the public health burden in the cardiovascular field and has a significant rate of morbidity and mortality. In the intermediate stages, exercise therapy is recommended by the guidelines, although supervised programs are scarcely available. This single-center observational study aimed to evaluate the long-term outcomes of patients with PAD and claudication receiving optimal medical care and follow-up or revascularization procedures or structured home-based exercise. Methods: The records of 1590 PAD patients with claudication were assessed at the Vascular Surgery Unit between 2008 and 2017. Based on the findings of the recruitment visit, patients were assigned to one of the three following groups according to the available guidelines: Revascularization (Rev), structured exercise therapy (Ex), or control (Co). The exercise program was prescribed at the hospital and executed at home with two daily 10-minute interval walking sessions at a pain-free speed. The number and date of deaths, all-cause hospitalizations, and peripheral revascularizations for 5 years were collected from the Emilia-Romagna regional database. Results: At entry, 137 patients underwent revascularization; 1087 patients were included in the Ex group, and 366 were included in the Co group. At baseline, patients in the Rev group were significantly younger and had fewer comorbidities (p < 0.001). A propensity score matching analysis was performed, and three balanced subgroups of 119 patients were each created. The mortality rate was significantly (p < 0.001) greater in the Co (45%) group than in the Rev (11%) and Ex (11%) groups, as was the incidence of all-cause hospitalizations (Co: 95%; Rev 56%; Ex 60%; p < 0.001). There were no differences in peripheral revascularizations (Co: 19%; Rev: 17%; Ex 11%). Conclusions: In PAD patients with claudication, both revascularization procedures and structured home-based exercise sessions are associated with better long-term clinical outcomes than walking advice and follow-up only.
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- 2024
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134. Management of Pediatric Superficial Partial-Thickness Burns with Polyhexamethylene Biguanide: Outcomes and Influencing Factors
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Aba Lőrincz, Hermann Nudelman, Anna Gabriella Lamberti, András Garami, Krisztina Adrienne Tiborcz, Tamás Zoltán Kovács, and Gergő Józsa
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pediatric ,child ,partial-thickness ,second-degree ,burn ,PHMB ,Medicine - Abstract
Background: In burn care, achieving swift healing with minimal complications remains paramount. This investigation assesses the role of polyhexamethylene biguanide (PHMB) in managing pediatric superficial partial-thickness burns, focusing on the effects of various patient-specific factors on recovery. Methods: Through a retrospective analysis of 27 pediatric cases treated with PHMB, we evaluated the impact of age, burn size, dressing frequency, treatment delay, cold therapy application, and analgesic usage on the time until reepithelialization (TTRE). Results: The majority of patients benefited from early cold therapy, yet only 1 in 3 patients received analgesics. A mean healing time of 8.78 (SD: 2.64) days was observed, with the extent of the burn showing a strong correlation (r: 0.63) to TTRE. Most treatments were managed outpatient, evidenced by a negligible average hospital stay (0.96 days), with recorded no complications. Conclusions: Our findings endorse PHMB as a promising treatment for superficial second-degree burns in young patients, due to the observed stable and rapid wound closure without the association of increased risks. Continued exploration into the optimal application of prehospital interventions and the comprehensive benefits of PHMB in pediatric burn management is necessary. Future research should assess long-term outcomes, including functionality, scar quality, and patient satisfaction.
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- 2024
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135. Correction: Defining and reporting exercise intensity in interventions for older adults: a modified Delphi process
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Bettina Wollesen, Mona Herden, Nicola Lamberti, and Christoforos D. Giannaki
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Geriatrics ,RC952-954.6 - Published
- 2024
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136. Toward a universal model for spatially structured populations
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Marrec, Loïc, Lamberti, Irene, and Bitbol, Anne-Florence
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Quantitative Biology - Populations and Evolution ,Physics - Biological Physics - Abstract
A key question in evolution is how likely a mutant is to take over. This depends on natural selection and on stochastic fluctuations. Population spatial structure can impact mutant fixation probabilities. We introduce a model for structured populations on graphs that generalizes previous ones by making migrations independent of birth and death. We demonstrate that by tuning migration asymmetry, the star graph transitions from amplifying to suppressing natural selection. The results from our model are universal in the sense that they do not hinge on a modeling choice of microscopic dynamics or update rules. Instead, they depend on migration asymmetry, which can be experimentally tuned and measured., Comment: 30 pages, 12 figures
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- 2020
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137. Hyperbranched DNA clusters
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Lattuada, Enrico, Caprara, Debora, Lamberti, Vincenzo, and Sciortino, Francesco
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Condensed Matter - Soft Condensed Matter - Abstract
Taking advantage of the base-pairing specificity and tunability of DNA interactions, we investigate the spontaneous formation of hyperbranched clusters starting from purposely designed DNA tetravalent nanostar monomers, encoding in their four sticky-ends the desired binding rules. Specifically, we combine molecular dynamics simulations and Dynamic Light Scattering experiments to follow the aggregation process of the DNA nanostars at different concentrations and temperatures. At odd with the Flory-Stockmayer predictions, we find that, even when all possible bonds are formed, the system does not reach percolation due to the presence of intracluster bonds. We present an extension of the Flory-Stockmayer theory that properly describes the numerical and the experimental results., Comment: The Supplementary Information is included in the pdf file
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- 2020
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138. Inferior results at long-term follow-up after extensor mechanism allograft reconstruction in septic compared to aseptic revision total knee arthroplasty
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Baldini, Andrea, Lamberti, Alfredo, Balato, Giovanni, Cavallo, Giuseppe, and Summa, Pierpaolo
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- 2023
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139. Impact of TMB/PD-L1 expression and pneumonitis on chemoradiation and durvalumab response in stage III NSCLC
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Joao V. Alessi, Biagio Ricciuti, Xinan Wang, Federica Pecci, Alessandro Di Federico, Giuseppe Lamberti, Arielle Elkrief, Scott J. Rodig, Emily S. Lebow, Jordan E. Eicholz, Maria Thor, Andreas Rimner, Adam J. Schoenfeld, Jamie E. Chaft, Bruce E. Johnson, Daniel R. Gomez, Mark M. Awad, and Narek Shaverdian
- Subjects
Science - Abstract
Abstract Although concurrent chemoradiation (CRT) and durvalumab consolidation has become a standard treatment for stage III non-small cell lung cancer (NSCLC), clinicopathologic and genomic factors associated with its efficacy remain poorly characterized. Here, in a multi-institutional retrospective cohort study of 328 patients treated with CRT and durvalumab, we identify that very high PD-L1 tumor proportion score (TPS) expression ( ≥ 90%) and increased tumor mutational burden (TMB) are independently associated with prolonged disease control. Additionally, we identify the impact of pneumonitis and its timing on disease outcomes among patients who discontinue durvalumab: compared to patients who experienced early-onset pneumonitis (
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- 2023
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140. Scalable and highly selective graphene-based ion-exchange membranes with tunable permselectivity
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Anna Aixalà-Perelló, Alessandro Pedico, Marco Laurenti, Enrica Fontananova, Sergio Bocchini, Ivan Vito Ferrari, and Andrea Lamberti
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Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Chemistry ,QD1-999 - Abstract
Abstract Graphene oxide (GO) membranes have been proved to be ion-selective thanks to their oxidized functional groups, which are naturally present on its surface. This ion selectivity, together with good mechanical strength, low cost, and simple synthesis, makes GO a great alternative material to conventional costly polymers for the production of ion-exchange membranes. This work focuses on how to produce GO membranes as ion-exchange membranes with a scalable approach and tunable permselectivity. Their physicochemical properties were subsequently investigated by means of selected characterization techniques. Results showed that GO membranes present good ion selectivity and size exclusion towards monovalent cations, reaching a permselectivity of up to 96%. Interestingly, UV-light irradiation of GO membranes can also be proposed as a green reduction method. GO reduction increases the permselectivity due to both a decrease in the dimension of the nanochannels and a reduction in the swelling degree of the membranes. The addition of binders was also investigated to improve the membranes’ mechanical properties. Finally, the ionic resistance of the membranes was measured by impedance spectroscopy, achieving 4.6 Ω cm2, orders of magnitude lower than the state-of-the-art graphene oxide-based membranes.
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- 2023
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141. Pasteurization of human milk affects the miRNA cargo of EVs decreasing its immunomodulatory activity
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Monica F. Torrez Lamberti, Leslie A. Parker, Claudio F. Gonzalez, and Graciela L. Lorca
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Medicine ,Science - Abstract
Abstract In this report, we evaluated the effect of the pasteurization (P) process of mother’s own milk (MOM) on the miRNA content of extracellular vesicles (EVs) and its impact on innate immune responses. Differences in size or particle number were not observed upon pasteurization of MOM (PMOM). However, significant differences were observed in the EV membrane marker CD63 and miRNA profiles. miRNA sequencing identified 33 differentially enriched miRNAs between MOMEV and PMOMEV. These changes correlated with significant decreases in the ability of PMOMEV to modulate IL-8 secretion in intestinal Caco2 cells where only MOMEV were able to decrease IL-8 secretion in presence of TNFα. While EVs from MOMEV and PMOMEV were both able to induce a tolerogenic M2-like phenotype in THP-1 macrophages, a significant decrease in the transcript levels of IL-10 and RNA sensing genes was observed with PMOMEV. Together, our data indicates that pasteurization of MOM impacts the integrity and functionality of MOMEV, decreasing its EVs-mediated immunomodulatory activity. This data provides biomarkers that may be utilized during the optimization of milk processing to preserve its bioactivity.
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- 2023
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142. Host nasopharyngeal transcriptome dataset of a SARS-CoV-2 positive Italian cohort
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Annamaria Salvati, Carlo Ferravante, Jessica Lamberti, Teresa Rocco, Elena Alexandrova, Ylenia D’Agostino, Maksim Sorokin, Victor Efimov, Anton Buzdin, Oriana Strianese, Giovanni Nassa, Roberta Tarallo, Alessandro Weisz, Francesca Rizzo, and Giorgio Giurato
- Subjects
Science - Abstract
Abstract The ongoing COVID-19 pandemic caused by SARS-CoV-2 has affected millions of people worldwide and has significant implications for public health. Host transcriptomics profiling provides comprehensive understanding of how the virus interacts with host cells and how the host responds to the virus. COVID-19 disease alters the host transcriptome, affecting cellular pathways and key molecular functions. To contribute to the global effort to understand the virus’s effect on host cell transcriptome, we have generated a dataset from nasopharyngeal swabs of 35 individuals infected with SARS-CoV-2 from the Campania region in Italy during the three outbreaks, with different clinical conditions. This dataset will help to elucidate the complex interactions among genes and can be useful in the development of effective therapeutic pathways.
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- 2023
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143. Lifestyle and mood correlates of cardiometabolic risk in people with serious mental illness on second-generation antipsychotic medications.
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Susanne U Miedlich, Priya Sahay, Telva E Olivares, J Steven Lamberti, Diane S Morse, Kevin P Brazill, Kavaljit H Chhabra, and Lauren Bainbridge
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Medicine ,Science - Abstract
IntroductionCardiovascular morbidity and mortality are high in people with serious mental illness (SMI). This problem is mediated, at least in part, by metabolic side effects of second-generation antipsychotics (SGAs) and by unhealthy lifestyle behaviors. We asked whether oral glucose tolerance testing (oGTT) or hemoglobin A1c (HbA1c) is superior in identifying people with SMI at high cardiometabolic risk and whether this risk is shaped by mood, cognition, or lifestyle habits.MethodsWe evaluated 40 patients with schizophrenia, schizoaffective, or bipolar disorder receiving SGAs by oGTT, HbA1c, comprehensive metabolic and lipid panels, and CRP. Mood was assessed using the Patient Health Questionnaire (PHQ-9), and cognition was assessed using the Saint Louis University Mental Status examination. Diet was assessed using the UK Diabetes and Diet Questionnaire (UKDDQ), and physical activity was assessed using daily step counts.ResultsMost patients had prediabetes (preDM) or diabetes mellitus (DM), 72.5% by oGTT, and 52.5% by HbA1c criteria. Pulse rates and insulin resistance indices (Homeostatic Model Assessment of Insulin Resistance, HOMA IR; Matsuda) were significantly different between patients classified as normal or with preDM/DM, using either oGTT or HbA1c criteria. Patients with preDM/DM by HbA1c but not oGTT criteria also had higher waist/hip ratios, triglyceride, and CRP levels (pConclusionsOGTT screening is superior to HbA1c screening in detecting preDM and DM early. Patients identified with preDM/DM by oGTT or HbA1c screening are insulin-resistant and have higher pulse rates. Abdominal obesity, unfavorable lipid profiles, and higher CRP levels were noted in patients screened by HbA1c, but not by oGTT. Low physical activity, low depression scores, and unhealthy diet habits were associated with higher CRP and higher glucose and triglyceride levels, respectively. Future studies should assess the impact of specifically tailored individual lifestyle counseling and medical management interventions in this high-risk population.
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- 2024
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144. The relationship between childhood interpersonal and non-interpersonal trauma and autobiographical memory: a systematic review
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Giovanni Borrelli, Annachiara Lamberti Zanardi, Claudia Scognamiglio, Vincenza Cinquegrana, and Raffaella Perrella
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childhood maltreatment ,overgeneral memory ,impairment of cognitive function ,earliest memories ,adverse childhood experience ,Psychology ,BF1-990 - Abstract
Childhood trauma can have negative effects on several domains of mental functioning, including Autobiographical Memory (AM). Conflicting results emerge in the scientific literature regarding the effects of childhood trauma on AM. In this review, we explored the relationship between the childhood trauma and AM, classifying childhood trauma as interpersonal, non-interpersonal and overall (interpersonal and non-interpersonal). We carried out a systematic literature review, following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA statement). From searching the PubMed, Scopus, and Web of Science databases, we identified 48 studies conducted from 2014 to 2023, which were included when they: (a) were written in English, (b) investigated the relationship between AM and childhood trauma, (c) included a sample of children, adolescents, or adults who had experienced childhood interpersonal and/or non-interpersonal trauma. Of the 48 eligible studies, 29 referred to trauma of an interpersonal nature, 12 to trauma of a non-interpersonal nature, and 7 to overall trauma. Regarding the relationship between childhood trauma and AM, 24 studies found a negative relationship between childhood interpersonal trauma and AM; among the articles on non-interpersonal trauma, 10 studies found no relevant relationship; in the studies on overall trauma, 4 articles found negative relationship between overall trauma and AM. The literature explored in our systematic review supports the prevalence of a negative relationship between interpersonal childhood trauma and AM. This relationship is present regardless of psychiatric disorders (e.g., Depression, Post Traumatic Stress Disorder, and Personality Disorders), and in the presence of the latter, AM results even more fragmented. Future research should use more accurate methodologies in identifying and classifying childhood trauma in order to more precisely determine its effect on AM.
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- 2024
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145. An Evaluation Testbed for Locomotion in Virtual Reality
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Cannavò, Alberto, Calandra, Davide, Pratticò, F. Gabriele, Gatteschi, Valentina, and Lamberti, Fabrizio
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Computer Science - Human-Computer Interaction ,Computer Science - Graphics - Abstract
A common operation performed in Virtual Reality (VR) environments is locomotion. Although real walking can represent a natural and intuitive way to manage displacements in such environments, its use is generally limited by the size of the area tracked by the VR system (typically, the size of a room) or requires expensive technologies to cover particularly extended settings. A number of approaches have been proposed to enable effective explorations in VR, each characterized by different hardware requirements and costs, and capable to provide different levels of usability and performance. However, the lack of a well-defined methodology for assessing and comparing available approaches makes it difficult to identify, among the various alternatives, the best solutions for selected application domains. To deal with this issue, this paper introduces a novel evaluation testbed which, by building on the outcomes of many separate works reported in the literature, aims to support a comprehensive analysis of the considered design space. An experimental protocol for collecting objective and subjective measures is proposed, together with a scoring system able to rank locomotion approaches based on a weighted set of requirements. Testbed usage is illustrated in a use case requesting to select the technique to adopt in a given application scenario., Comment: This paper is accepted for inclusion in a future issue of IEEE Transactions on Visualization and Computer Graphics (TVCG). Copyright IEEE 2020
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- 2020
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146. Master regulators of evolution and the microbiome in higher dimensions
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Eble, Holger, Joswig, Michael, Lamberti, Lisa, and Ludington, Will
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Quantitative Biology - Quantitative Methods ,Mathematics - Metric Geometry - Abstract
A longstanding goal of biology is to identify the key genes and species that critically impact evolution, ecology, and health. Network analysis has revealed keystone species that regulate ecosystems and master regulators that regulate cellular genetic networks. Yet these studies have focused on pairwise biological interactions, which can be affected by the context of genetic background and other species present generating higher-order interactions. The important regulators of higher-order interactions are unstudied. To address this, we applied a new high-dimensional geometry approach that quantifies epistasis in a fitness landscape to ask how individual genes and species influence the interactions in the rest of the biological network. We then generated and also reanalyzed 5-dimensional datasets (two genetic, two microbiome). We identified key genes (e.g. the rbs locus and pykF) and species (e.g. Lactobacilli) that control the interactions of many other genes and species. These higher-order master regulators can induce or suppress evolutionary and ecological diversification by controlling the topography of the fitness landscape. Thus, we provide mathematical intuition and justification for exploration of biological networks in higher dimensions., Comment: 77 pages, various figures
- Published
- 2020
147. Sensitivity Analysis of a Graphene Field-Effect Transistors by means of Design of Experiments
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Spinelli, Giovanni, Lamberti, Patrizia, Tucci, Vincenzo, Pasadas, Francisco, and Jiménez, David
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Graphene, due to its unique electronic structure favoring high carrier mobility, is considered a promising material for use in high-speed electronic devices in the post-silicon electronic era. For this reason, experimental research on graphene-based field-effect transistors (GFETs) has rapidly increased in the last years. However, despite the continuous progress in the optimization of such devices many critical issues remain to be solved such as their reproducibility and performance uniformity against possible variations originated by the manufacturing processes or the operating conditions. In the present work, changes of the ID-VDS characteristics of a Graphene Field-Effect Transistors, caused by a tolerance of 10% in the active channel (i.e. its length and width) and in the top oxide thickness are numerically investigated in order to assess the reliability of such devices. Design of Experiments (DoE) is adopted with the aim to identify the most influential factors on the electrical performance of the device, so that the fabrication process may be suitably optimized., Comment: 13 pages,8 figures, 2 tables
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- 2020
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148. Shape perturbation of Grushin eigenvalues
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Lamberti, Pier Domenico, Luzzini, Paolo, and Musolino, Paolo
- Subjects
Mathematics - Analysis of PDEs ,Mathematics - Spectral Theory ,35J70, 35B20, 35P05, 47A10, 49K40 - Abstract
We consider the spectral problem for the Grushin Laplacian subject to homogeneous Dirichlet boundary conditions on a bounded open subset of $\mathbb{R}^N$. We prove that the symmetric functions of the eigenvalues depend real analytically upon domain perturbations and we prove an Hadamard-type formula for their shape differential. In the case of perturbations depending on a single scalar parameter, we prove a Rellich-Nagy-type theorem which describes the bifurcation phenomenon of multiple eigenvalues. As corollaries, we characterize the critical shapes under isovolumetric and isoperimetric perturbations in terms of overdetermined problems and we deduce a new proof of the Rellich-Pohozaev identity for the Grushin eigenvalues.
- Published
- 2020
149. Mixed-Reality Robotic Games: Design Guidelines for Effective Entertainment with Consumer Robots
- Author
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Pratticò, F. Gabriele and Lamberti, Fabrizio
- Subjects
Computer Science - Human-Computer Interaction ,Computer Science - Graphics ,Computer Science - Robotics - Abstract
In recent years, there has been an increasing interest in the use of robotic technology at home. A number of service robots appeared on the market, supporting customers in the execution of everyday tasks. Roughly at the same time, consumer level robots started to be used also as toys or gaming companions. However, gaming possibilities provided by current off-the-shelf robotic products are generally quite limited, and this fact makes them quickly loose their attractiveness. A way that has been proven capable to boost robotic gaming and related devices consists in creating playful experiences in which physical and digital elements are combined together using Mixed Reality technologies. However, these games differ significantly from digital- or physical only experiences, and new design principles are required to support developers in their creative work. This papers addresses such need, by drafting a set of guidelines which summarize developments carried out by the research community and their findings., Comment: This paper is accepted for inclusion in future issue of IEEE Consumer Electronic Magazine. Copyright IEEE 2020
- Published
- 2020
- Full Text
- View/download PDF
150. Building Trust in Autonomous Vehicles: Role of Virtual Reality Driving Simulators in HMI Design
- Author
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Morra, Lia, Lamberti, Fabrizio, Pratticó, F. Gabriele, La Rosa, Salvatore, and Montuschi, Paolo
- Subjects
Computer Science - Human-Computer Interaction ,Computer Science - Artificial Intelligence ,Computer Science - Graphics - Abstract
The investigation of factors contributing at making humans trust Autonomous Vehicles (AVs) will play a fundamental role in the adoption of such technology. The user's ability to form a mental model of the AV, which is crucial to establish trust, depends on effective user-vehicle communication; thus, the importance of Human-Machine Interaction (HMI) is poised to increase. In this work, we propose a methodology to validate the user experience in AVs based on continuous, objective information gathered from physiological signals, while the user is immersed in a Virtual Reality-based driving simulation. We applied this methodology to the design of a head-up display interface delivering visual cues about the vehicle' sensory and planning systems. Through this approach, we obtained qualitative and quantitative evidence that a complete picture of the vehicle's surrounding, despite the higher cognitive load, is conducive to a less stressful experience. Moreover, after having been exposed to a more informative interface, users involved in the study were also more willing to test a real AV. The proposed methodology could be extended by adjusting the simulation environment, the HMI and/or the vehicle's Artificial Intelligence modules to dig into other aspects of the user experience.
- Published
- 2020
- Full Text
- View/download PDF
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