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Piezoelectric energy harvesting from traffic load has gained extensive attention for potentiality as a renewable energy source. In existing in situ experiments, generally only one vehicle is employed, while the wheel-path of the vehicle and embedded positions of piezoelectric energy harvester (PEH) units are both fixed. However, in an actual traffic condition, vehicles travel randomly along width of pavements, which means the wheel-path varies over time and among vehicles. In this study, an electromechanical model is established for the PEH units under actual traffic conditions with wheel-path distribution, and is validated with finite element analysis and experiments. Then the electrical performance of PEH units embedded at various locations along pavements' lateral direction is investigated under various traffic speeds. It is found that the optimal lateral embedded locations of the PEH units should be adjusted according to the prescribed traffic speed of the roads. Specifically, PEH units should be embedded at the tire-road contact areas for road with low traffic speeds (<15 m/s), while they should be embedded at the center of the pavement with high traffic speeds (>25 m/s). These mathematical results may serve as guidelines for selecting optimal lateral embedded locations for PEH units embedded in pavements. [ABSTRACT FROM AUTHOR]

Summary: The overlapping of two or more types of neural autoantibodies in one patient has increasingly been documented in recent years. The coexistence of myelin oligodendrocyte glycoprotein (MOG) and N-methyl-d-aspartate receptor (NMDAR) antibodies is most common, which leads to a unique condition known as the MOG antibody and NMDAR antibody overlapping syndrome (MNOS). Here, we have reviewed the pathogenesis, clinical manifestations, paraclinical features, and treatment of MNOS. Forty-nine patients with MNOS were included in this study. They were young males with a median onset age of 23 years. No tumors were observed in the patients, and 24 of them reported prodromal symptoms. The most common clinical presentations were psychiatric symptoms (35/49) and seizures (25/49). Abnormalities on magnetic resonance imaging involved the brainstem (11/49), cerebellum (9/49), and parietal lobe (9/49). Most patients mostly responded to immunotherapy and had a good long-term prognosis. However, the overall recurrence rate of MNOS was higher than that of mono antibody-positive diseases. The existence of concurrent NMDAR antibodies should be suspected in patients with MOG antibody-associated disease having psychiatric symptoms, seizures, movement disorders, or autonomic dysfunction. Similarly, serum MOG antibody testing should be performed when patients with anti-NMDAR encephalitis present with atypical clinical manifestations, such as visual impairment and limb weakness, and neuroradiological findings, such as optic nerve, spinal cord, or infratentorial involvement or meningeal enhancement. Early detection of the syndrome and prompt treatment can be beneficial for these patients, and maintenance immunosuppressive therapy is recommended due to the high overall recurrence rate of the syndrome. Myelin oligodendrocyte glycoprotein (MOG) antibodies and N-methyl-d -aspartate receptor (NMDAR) antibodies can be concurrently detected in certain patients, which leads to a unique condition known as the MOG antibody and NMDAR antibody overlapping syndrome (MNOS). Here, we have reviewed the pathogenesis, clinical manifestations, paraclinical features, and treatment of MNOS. Graphical Abstract [ABSTRACT FROM AUTHOR]

The isothermal forging process of blades of a β-γ high niobium containing Ti Al based alloy was simulated by using a Deform-3D software,with focus on the analysis of the effective strain,effective stress and temperature distributions. The results demonstrate that the effective strains of the blade body and rabbet uniformly distribute during the isothermal forging process. With the increase of top die speed and preheating temperature,the effective stress decreases and the dynamic recrystallization is easy to take place. The preheating temperature of 1250-1300 ℃ and the top die speed of 1.0-1.5 mm·s-1 help to improve the quality of the forged blades.

Background: The T-cell spot test for tuberculosis (T-SPOT.TB) with false positives and false negatives exists in the diagnosis of spinal infection. The objective of this study was to increase the diagnostic value precision and specificity of T-SPOT.TB in the identification of spinal tuberculosis (TB). Patients and Methods: Fifty-two patients suspected of having spinal TB from April 2020 to December 2021 were included, and all patients received T-SPOT.TB tests and surgical treatment. The composite reference standard was used to diagnose spinal TB. The T-SPOT.TB values were compared according to whether spinal TB was diagnosed, and the optimal cutoff values of diagnosis was determined by receiver operating characteristic (ROC) curve analysis. Results: All patients were followed up for at least one year. The sensitivity, specificity, positive predictive value, and negative predictive value of the T-SPOT.TB test in assisting the diagnosis of spinal TB were 91.67%, 71.43%, 73.33%, and 90.9%, respectively. We determined that the values of early secreted antigen target 6 (ESAT-6) antigen and culture filter protein 10 (CFP-10) antigen were determined to be diagnostic for spinal tuberculosis, with areas under the curve equal to 0.776 and 0.852, respectively; the cutoff values for the diagnosis of ESAT-6 antigen and CFP-10 antigen were calculated as 40.5 spot forming cells (SFCs) per 106 peripheral blood mononuclear cells (PBMCs) and 26.5 SFCs/106 PBMCs, respectively. Follow-up for all patients was 12 months, and in this period, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), visual analog scale (VAS) score, and Oswestry Dysfunction Index (ODI%) were different between groups (p < 0.05). Conclusions: The T-SPOT.TB test is considered a milestone discovery in the diagnosis of TB; there are still many false-positive samples, but the diagnostic specificity was improved in the study, allowing spinal infections to be treated accurately and in a timely manner. [ABSTRACT FROM AUTHOR]