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103. Considerable efficacy of retreatment of chronic Hepatitis C Genotype 1 (G1) Infection with Boceprevir (Victrelis®) in German Real-Life: Interim results from the ongoing Novus study

Author

Buggisch, P, primary, Löhr, H, additional, Teuber, G, additional, Steffens, H, additional, Kraus, M, additional, John, C, additional, Geyer, P, additional, Weber, B, additional, Witthoeft, T, additional, Herrmann, A, additional, Hoesl, M, additional, Naumann, U, additional, Dahhan, T, additional, Hartmann, D, additional, Dreher, B, additional, and Bilzer, M, additional

Published
2014
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104. Treatment of chronic Hepatitis C Genotype 1 (G1) infection with Boceprevir (BOC) in German Real-Life: Impact of Hemoglobin (Hb) decline on virologic response

Author

Teuber, G, primary, Buggisch, P, additional, Löhr, H, additional, Steffens, H, additional, Kraus, M, additional, John, C, additional, Geyer, P, additional, Weber, B, additional, Witthoeft, T, additional, Herrmann, A, additional, Hoesl, M, additional, Naumann, U, additional, Dahhan, T, additional, Hartmann, D, additional, Dreher, B, additional, and Bilzer, M, additional

Published
2014
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105. Treatment of previously untreated patients with chronic HCV genotype 1 infection with Boceprevir (BOC) in German real-life: High efficacy in patients with early virologic response

Author

Buggisch, P, primary, Löhr, H, additional, Teuber, G, additional, Steffens, H, additional, Kraus, M, additional, John, C, additional, Geyer, P, additional, Weber, B, additional, Witthoeft, T, additional, Herrmann, A, additional, Hoesl, M, additional, Naumann, U, additional, Dahhan, T, additional, Hartmann, D, additional, Dreher, B, additional, and Bilzer, M, additional

Published
2014
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106. High virologic response rate at End of Treatment (EOT) following triple therapy of previously untreated HCV Genotype 1 (G1) infection with boceprevir in German real-life

Author

Buggisch, P, primary, Löhr, H, additional, Teuber, G, additional, Steffens, H, additional, Kraus, M, additional, John, C, additional, Geyer, P, additional, Weber, B, additional, Witthoeft, T, additional, Herrmann, A, additional, Hoesl, M, additional, Naumann, U, additional, Dahhan, T, additional, Hartmann, D, additional, Dreher, B, additional, and Bilzer, M, additional

Published
2014
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107. P1137 TREATMENT OF CHRONIC HCV GENOTYPE 1 (G1) INFECTION WITH BOCEPREVIR IN GERMAN REAL-LIFE: HIGH EFFICACY TOGETHER WITH MODERATE TREATMENT DISCONTINUATION RATES IN TREATMENT-NAIVE PATIENTS

Author

Buggisch, P., primary, Löhr, H., additional, Teuber, G., additional, Steffens, H., additional, Kraus, M.R., additional, John, C., additional, Geyer, P.R., additional, Weber, B., additional, Witthöft, T., additional, Herrmann, A., additional, Hoesl, M., additional, Naumann, U., additional, Dahhan, T., additional, Hartmann, D., additional, Dreher, B., additional, and Bilzer, M., additional

Published
2014
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108. LBP517 - Add on Interferon-Alpha-2a for the Treatment of HBeAg Negative Hepatitis B Patients Receiving Effective Nucleos(t)ide Therapy: Interim Results of the Prospective Multicentre PADD-On Trial

Author

Sprinzl, M.F., Grambihler, A., Teuber, G., Ebert, M., Zeuzem, S., Lohmeyer, J., Cornberg, M., Tacke, F., Löhr, H., Berg, T., Lammert, F., Schott, E., Heyne, R., Berg, C., Dollinger, M., Pathil-Warth, A., Geisler, F., Spengler, U., Thimme, R., Weigand, K., Alshuth, U., Ehrlich, A., Riedl, M., Kittner, J., Schuchmann, M., and Galle, P.R.

Published
2016
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110. Treatment of chronic hepatitis C Genotype 1 (G1) infection with boceprevir (Victrelis®) in the German real-life setting: First results for treatment-naïve patients from the Novus observational study

Author

Buggisch, P, primary, Löhr, H, additional, Teuber, G, additional, Steffens, H, additional, Kraus, M, additional, John, C, additional, Geyer, P, additional, Weber, B, additional, Witthöft, T, additional, Herrmann, A, additional, Hoesl, M, additional, Naumann, U, additional, Dahhan, T, additional, Hartmann, D, additional, Dreher, B, additional, and Bilzer, M, additional

Published
2013
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111. Changes of demographic- and disease characteristics of patients with chronic HCV genotype 1 infection In Germany during the past decade

Author

Buggisch, P, primary, Löhr, H, additional, Teuber, G, additional, Steffens, H, additional, Kraus, M, additional, John, C, additional, Geyer, P, additional, Weber, B, additional, Witthöft, T, additional, Herrmann, A, additional, Hoesl, M, additional, Naumann, U, additional, Dahhan, T, additional, Hartmann, D, additional, Dreher, B, additional, and Bilzer, M, additional

Published
2013
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135. Liver--infiltrating T helper cells in autoimmune chronic active hepatitis stimulate the production of autoantibodies against the human asialoglycoprotein receptor in vitro.

Author

Löhr, H., Treichel, U., Poralla, T., Manns, M., Büschenfelde, K. H. Meyer Zum, and Fleischer, B.

Subjects
*AUTOANTIBODIES, *IMMUNOGLOBULINS, *HEPATITIS, *T cells, *LIVER diseases, *AUTOIMMUNE diseases
Abstract

Autoantibodies against the human asialoglycoprotein receptor (ASGPR) occur in the sera of patients with autoimmune liver disorders. Liver-infiltrating T cell clones that specifically recognize the ASGPR have been described in patients with autoimmune chronic active hepatitis (AI-CAH) and primary biliary cirrhosis (PBC). Recently, we have shown that peripheral blood mononuclear cells (PBMC) from patients with AI-CAH or PBC but not chronic viral hepatitis secreted anti-ASGPR antibodies in vitro. In this study we characterized the influence of liver-infiltrating T cells on the secretion of ASGPR-specific autoantibodies by autologous B cells in cell culture supernatants. T cell clones from liver biopsies of three patients with chronic autoimmune liver disorders (one with AICAH, two with PBC) were isolated and investigated for their proliferative response to soluble ASGPR and their helper function provided to autoantibody-secreting B lymphocytes. PBMC from these patients secreted autoantibodies spontaneously in their cell culture supernatants and showed a proliferative response to ASGPR. T cell-depleted PBMC, however, tacked spontaneous antibody secretion. Four CD4+ CD8- liver-infiltrating T cell clones showed a proliferative response to ASGPR and also induced spontaneous anti-ASGPR antibody production in cell culture supernatants when added to autologous T cell depleted PBMC. Activated supernatants of these T cell clones failed to induce antibody production, None of seven CD4+ CD8- and two CD4+ CD8- T cell clones nonresponding to ASGPR provided this help for antibody secretion. Anti-ASGPR secretion in vitro could not be inhibited by the addition of MoAbs raised against monomorphic determinants on HLA class II molecules. The addition of purified ASGPR or polyclonal-activating pokeweed mitogen showed no influence on the production of autoantibodies in these cultures. These data show that B lymphocytes require T cell help for the production of ASGPR-specific antibodies. This help can be provided by ASGPR-responsive T helper cells via cellular interactions. [ABSTRACT FROM AUTHOR]

Published
1992

141. Strahlenrisiko bei der Herzkatheterisierung und Ankiokardiographie des Kindes

Author

Borchers Hd, Vogel H, Lassrich Ma, R. Jantzen, Keck Ew, and Löhr H

Subjects
medicine.medical_specialty, Radiation risk, medicine.diagnostic_test, business.industry, Morbidity risk, Pediatrics, Perinatology and Child Health, Skin exposure, medicine, Radiology, Angiocardiography, Malignancy, medicine.disease, business
Abstract

The skin exposure and the energy transferred to the body (integraldose) increase with the child's growth. Nevertheless the mean body dose (integraldose/body-weight) is the highest in the youngest patient. The probability of roentgenray induced letal malignancy is approximately 1:9000--1:17000. The morbidity risk may be 2--3 times higher at the least.

Published
1980
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142. Viszerale Kala-Azar-Erkrankung beim Kind*

Author

Löhr H and Wolf H

Subjects
medicine.medical_specialty, Collagen disease, business.industry, Spleen, Brucellosis, General Medicine, Disease, medicine.disease, Gastroenterology, Typhoid fever, Transaminase, medicine.anatomical_structure, Internal medicine, Rheumatoid arthritis, medicine, Cortisone, business, medicine.drug
Abstract

Repeated blood cultures were negative in a six-year-old boy with high septic temperature. Rheumatoid arthritis, typhoid and brucellosis were excluded. There was no evidence of leukaemia (bone-marrow tests). There was hepatomegaly with increased transaminase activity. Cortisone treatment was begun for suspected collagen disease. Several liver needle biopsies at first revelaed increasingly severe necrotising changes, predominantly in the centres of the acini. There were no parasites demonstrable histologically. The spleen was increased in the isotope scan but, covered by the liver, not definitely palpable. Diagnosis of mediterranean Kala-Azar disease was then suspected (the parents reporting a camping holiday in Yugoslavia) and finally proven serologically. The previously treatment-resistant disease improved dramatically after administration of trivalent antimony (Fuadin).

Published
1978
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144. Integrating psychoeducation in a basic computer skills course for people suffering from social anxiety: participants' experiences

Author

Löhr HD, Rosenvinge JH, and Wynn R

Subjects
Medicine (General), R5-920
Abstract

Hildegard D Löhr1,2, Jan H Rosenvinge1,3, Rolf Wynn2,41Division of General Psychiatry, University Hospital of North Norway, 2Telemedicine Research Group, Department of Clinical Medicine, Faculty of Health Sciences, 3Department of Psychology, Faculty of Health Sciences, University of Tromsø, 4Division of Addiction and Specialized Psychiatry, University Hospital of North Norway, Tromsø, NorwayAbstract: We describe a psychoeducational program integrated in a basic computer skills course for participants suffering from social anxiety. The two main aims of the course were: that the participants learn basic computer skills, and that the participants learn to cope better with social anxiety. Computer skills were taught by a qualified teacher. Psychoeducation and cognitive therapy skills, including topics such as anxiety coping, self-accept, and self-regulation, were taught by a clinical psychologist. Thirteen of 16 participants completed the course, which lasted 11 weeks. A qualitative analysis was performed, drawing on observations during the course and on interviews with the participants. The participants were positive about the integration of psychoeducation sessions in the computer course, and described positive outcomes for both elements, including improved computer skills, improved self-esteem, and reduced social anxiety. Most participants were motivated to undertake further occupational rehabilitation after the course.Keywords: cognitive therapy, information technology, occupational rehabilitation, psychoeducation, self-help, social anxiety

Published
2011

149. Pneumatoceles and pneumothoraces complicating staphylococcal pneumonia: treatment by synchronous independent lung ventilation.

Author

Lohse, A W, Klein, O, Hermann, E, Löhr, H, Kreitner, K F, Steppling, H, Meyer zum Büschenfelde, K H, and Staritz, M

Abstract

A 54 year old man with a staphylococcal sepsis developed staphylococcal pneumonia complicated by multiple pneumatoceles and bilateral tension pneumothoraces caused by bronchopleural fistulae. Excessive enlargement of the right sided pneumatoceles and a tension pneumothorax not improved by drainage led to mediastinal shift and compression of the right lung. Reversal of the mediastinal shift and closure of the bronchopleural fistulae was achieved by assisted independent lung ventilation. [ABSTRACT FROM AUTHOR]

Published
1993

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