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5,539 results on '"Krumholz, Harlan M."'

109. Abstract 14219: Are There Sex Differences in the Imaging Modalities and Early Use of Echocardiography in Elderly Patients With Pulmonary Embolism?

Author

Mehdipoor, Ghazaleh, Jimenez, David, Muriel, Alfonso, Piazza, Gregory, Rosovsky, Rachel, Madridano, Olga, Lopez-Saez, Juan Bosco, Mellado, Meritxell, Diaz Brasero, Ana María, OʼDonoghue, Michelle, BERTOLETTI, Laurent, Lopez-Jimenez, Luciano, Nunez-Fernandez, Manuel, Blanco-Molina, Angeles, Prince, Martin R, Gerhard-Herman, Marie, Bikdeli, Behnood, Krumholz, Harlan M, and Monreal, Manuel

Published
2022
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111. Abstract 13807: Sex Differences in Patients Characteristics, Risk Factors, and Symptomatology in Older Adults With Pulmonary Embolism: Findings From the SERIOUS-PE Study

Author

Bikdeli, Behnood, Jimenez, David, Piazza, Gregory, Muriel, Alfonso, wang, yun, Khairani, Candrika D, Rosovsky, Rachel, Madridano, Olga, Lopez-Saez, Juan Bosco, Mellado, Meritxell, Diaz Brasero, Ana María, Mehdipoor, Ghazaleh, OʼDonoghue, Michelle, Spagnolo, Primavera A, Lu, Yuan, BERTOLETTI, Laurent, Lopez-Jimenez, Luciano, Nunez-Fernandez, Manuel J, Blanco-Molina, Angeles, Bates, Shannon, Gerhard-Herman, Marie, Goldhaber, Samuel, Monreal, Manuel, and Krumholz, Harlan M

Published
2022
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113. Abstract 12596: Comparison of the Efficacy and Safety of Direct Oral Anticoagulants With Vitamin K Antagonists in Patients With Thrombotic Antiphospholipid Syndrome: Systematic Review and Meta-analysis of Randomized Clinical Trials

Author

Bejjani, Antoine, Khairani, Candrika D, Piazza, Gregory, Jimenez, David, Monreal, Manuel, Chatterjee, Saurav, Pengo, Vittorio, Woller, Scott, Cortes-Hernandez, Josefina, Connors, Jean M, Kanthi, Yogendra, Krumholz, Harlan M, Middeldorp, Saskia, Falanga, Anna, Cushman, Mary, Goldhaber, Samuel Z, Garcia, David, and Bikdeli, Behnood

Published
2022
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118. Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review

Author

Talasaz, Azita H., Sadeghipour, Parham, Kakavand, Hessam, Aghakouchakzadeh, Maryam, Kordzadeh-Kermani, Elaheh, Van Tassell, Benjamin W., Gheymati, Azin, Ariannejad, Hamid, Hosseini, Seyed Hossein, Jamalkhani, Sepehr, Sholzberg, Michelle, Monreal, Manuel, Jimenez, David, Piazza, Gregory, Parikh, Sahil A., Kirtane, Ajay J., Eikelboom, John W., Connors, Jean M., Hunt, Beverley J., Konstantinides, Stavros V., Cushman, Mary, Weitz, Jeffrey I., Stone, Gregg W., Krumholz, Harlan M., Lip, Gregory Y.H., Goldhaber, Samuel Z., and Bikdeli, Behnood

Published
2021
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119. Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study

Author

Mahajan, Shiwani, Srinivasan, Rajesh, Redlich, Carrie A., Huston, Sara K., Anastasio, Kelly M., Cashman, Lisa, Massey, Dorothy S., Dugan, Andrew, Witters, Dan, Marlar, Jenny, Li, Shu-Xia, Lin, Zhenqiu, Hodge, Domonique, Chattopadhyay, Manas, Adams, Mark D., Lee, Charles, Rao, Lokinendi V., Stewart, Chris, Kuppusamy, Karthik, Ko, Albert I., and Krumholz, Harlan M.

Published
2021
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120. SalivaDirect: A simplified and flexible platform to enhance SARS-CoV-2 testing capacity

Author

Anastasio, Kelly, Askenase, Michael H., Batsu, Maria, Bickerton, Sean, Brower, Kristina, Bucklin, Molly L., Cahill, Staci, Cao, Yiyun, Courchaine, Edward, DeIuliis, Giuseppe, Earnest, Rebecca, Geng, Bertie, Goldman-Israelow, Benjamin, Handoko, Ryan, Khoury-Hanold, William, Kim, Daniel, Knaggs, Lynda, Kuang, Maxine, Lapidus, Sarah, Lim, Joseph, Linehan, Melissa, Lu-Culligan, Alice, Martin, Anjelica, Matos, Irene, McDonald, David, Minasyan, Maksym, Nakahata, Maura, Naushad, Nida, Nouws, Jessica, Obaid, Abeer, Odio, Camila, Oh, Ji Eun, Omer, Saad, Park, Annsea, Park, Hong-Jai, Peng, Xiaohua, Petrone, Mary, Prophet, Sarah, Rice, Tyler, Rose, Kadi-Ann, Sewanan, Lorenzo, Sharma, Lokesh, Shaw, Albert C., Shepard, Denise, Smolgovsky, Mikhail, Sonnert, Nicole, Strong, Yvette, Todeasa, Codruta, Valdez, Jordan, Velazquez, Sofia, Vijayakumar, Pavithra, White, Elizabeth B., Yang, Yexin, Vogels, Chantal B.F., Watkins, Anne E., Harden, Christina A., Brackney, Doug E., Shafer, Jared, Wang, Jianhui, Caraballo, César, Kalinich, Chaney C., Ott, Isabel M., Fauver, Joseph R., Kudo, Eriko, Lu, Peiwen, Venkataraman, Arvind, Tokuyama, Maria, Moore, Adam J., Muenker, M. Catherine, Casanovas-Massana, Arnau, Fournier, John, Bermejo, Santos, Campbell, Melissa, Datta, Rupak, Nelson, Allison, Dela Cruz, Charles S., Ko, Albert I., Iwasaki, Akiko, Krumholz, Harlan M., Matheus, J.D., Hui, Pei, Liu, Chen, Farhadian, Shelli F., Sikka, Robby, Wyllie, Anne L., and Grubaugh, Nathan D.

Published
2021
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121. Renin–angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis

Author

Morales, Daniel R, Conover, Mitchell M, You, Seng Chan, Pratt, Nicole, Kostka, Kristin, Duarte-Salles, Talita, Fernández-Bertolín, Sergio, Aragón, Maria, DuVall, Scott L, Lynch, Kristine, Falconer, Thomas, van Bochove, Kees, Sung, Cynthia, Matheny, Michael E, Lambert, Christophe G, Nyberg, Fredrik, Alshammari, Thamir M, Williams, Andrew E, Park, Rae Woong, Weaver, James, Sena, Anthony G, Schuemie, Martijn J, Rijnbeek, Peter R, Williams, Ross D, Lane, Jennifer C E, Prats-Uribe, Albert, Zhang, Lin, Areia, Carlos, Krumholz, Harlan M, Prieto-Alhambra, Daniel, Ryan, Patrick B, Hripcsak, George, and Suchard, Marc A

Published
2021
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122. Trends in Drug Utilization, Glycemic Control, and Rates of Severe Hypoglycemia, 2006–2013

Author

Lipska, Kasia J, Yao, Xiaoxi, Herrin, Jeph, McCoy, Rozalina G, Ross, Joseph S, Steinman, Michael A, Inzucchi, Silvio E, Gill, Thomas M, Krumholz, Harlan M, and Shah, Nilay D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Diabetes, Prevention, Adolescent, Adult, Aged, Blood Glucose, Comorbidity, Diabetes Mellitus, Type 2, Dipeptidyl-Peptidase IV Inhibitors, Drug Utilization, Female, Glycated Hemoglobin, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Logistic Models, Male, Metformin, Middle Aged, Retrospective Studies, Sulfonylurea Compounds, Thiazolidinediones, Young Adult, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences, Health sciences
Abstract

ObjectiveTo examine temporal trends in utilization of glucose-lowering medications, glycemic control, and rate of severe hypoglycemia among patients with type 2 diabetes (T2DM).Research design and methodsUsing claims data from 1.66 million privately insured and Medicare Advantage patients with T2DM from 2006 to 2013, we estimated the annual 1) age- and sex-standardized proportion of patients who filled each class of agents; 2) age-, sex-, race-, and region-standardized proportion with hemoglobin A1c (HbA1c)

Published
2017

123. Identification of Emergency Department Visits in Medicare Administrative Claims: Approaches and Implications

Author

Venkatesh, Arjun K, Mei, Hao, Kocher, Keith E, Granovsky, Michael, Obermeyer, Ziad, Spatz, Erica S, Rothenberg, Craig, Krumholz, Harlan M, and Lin, Zhenqui

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Emergency Care, Health Services, Clinical Research, Aged, Aged, 80 and over, Clinical Coding, Emergency Service, Hospital, Female, Hospitalization, Humans, Male, Medicare, United States, Public Health and Health Services, Emergency & Critical Care Medicine, Clinical sciences
Abstract

ObjectivesAdministrative claims data sets are often used for emergency care research and policy investigations of healthcare resource utilization, acute care practices, and evaluation of quality improvement interventions. Despite the high profile of emergency department (ED) visits in analyses using administrative claims, little work has evaluated the degree to which existing definitions based on claims data accurately captures conventionally defined hospital-based ED services. We sought to construct an operational definition for ED visitation using a comprehensive Medicare data set and to compare this definition to existing operational definitions used by researchers and policymakers.MethodsWe examined four operational definitions of an ED visit commonly used by researchers and policymakers using a 20% sample of the 2012 Medicare Chronic Condition Warehouse (CCW) data set. The CCW data set included all Part A (hospital) and Part B (hospital outpatient, physician) claims for a nationally representative sample of continuously enrolled Medicare fee-for-services beneficiaries. Three definitions were based on published research or existing quality metrics including: 1) provider claims-based definition, 2) facility claims-based definition, and 3) CMS Research Data Assistance Center (ResDAC) definition. In addition, we developed a fourth operational definition (Yale definition) that sought to incorporate additional coding rules for identifying ED visits. We report levels of agreement and disagreement among the four definitions.ResultsOf 10,717,786 beneficiaries included in the sample data set, 22% had evidence of ED use during the study year under any of the ED visit definitions. The definition using provider claims identified a total of 4,199,148 ED visits, the facility definition 4,795,057 visits, the ResDAC definition 5,278,980 ED visits, and the Yale definition 5,192,235 ED visits. The Yale definition identified a statistically different (p < 0.05) collection of ED visits than all other definitions including 17% more ED visits than the provider definition and 2% fewer visits than the ResDAC definition. Differences in ED visitation counts between each definition occurred for several reasons including the inclusion of critical care or observation services in the ED, discrepancies between facility and provider billing regulations, and operational decisions of each definition.ConclusionCurrent operational definitions of ED visitation using administrative claims produce different estimates of ED visitation based on the underlying assumptions applied to billing data and data set availability. Future analyses using administrative claims data should seek to validate specific definitions and inform the development of a consistent, consensus ED visitation definitions to standardize research reporting and the interpretation of policy interventions.

Published
2017

126. Bigeometric Organization of Deep Nets

Author

Cloninger, Alexander, Coifman, Ronald R., Downing, Nicholas, and Krumholz, Harlan M.

Subjects
Statistics - Machine Learning, Computer Science - Learning
Abstract

In this paper, we build an organization of high-dimensional datasets that cannot be cleanly embedded into a low-dimensional representation due to missing entries and a subset of the features being irrelevant to modeling functions of interest. Our algorithm begins by defining coarse neighborhoods of the points and defining an expected empirical function value on these neighborhoods. We then generate new non-linear features with deep net representations tuned to model the approximate function, and re-organize the geometry of the points with respect to the new representation. Finally, the points are locally z-scored to create an intrinsic geometric organization which is independent of the parameters of the deep net, a geometry designed to assure smoothness with respect to the empirical function. We examine this approach on data from the Center for Medicare and Medicaid Services Hospital Quality Initiative, and generate an intrinsic low-dimensional organization of the hospitals that is smooth with respect to an expert driven function of quality.

Published
2015

134. Association of marital/partner status with hospital readmission among young adults with acute myocardial infarction

Author

Zhu, Cenjing, primary, Dreyer, Rachel P., additional, Li, Fan, additional, Spatz, Erica S., additional, Caraballo, César, additional, Mahajan, Shiwani, additional, Raparelli, Valeria, additional, Leifheit, Erica C., additional, Lu, Yuan, additional, Krumholz, Harlan M., additional, Spertus, John A., additional, D’Onofrio, Gail, additional, Pilote, Louise, additional, and Lichtman, Judith H., additional

Published
2024
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136. A Multicenter Evaluation of the Impact of Therapies on Deep Learning-based Electrocardiographic Hypertrophic Cardiomyopathy Markers

Author

Dhingra, Lovedeep S, primary, Sangha, Veer, additional, Aminorroaya, Arya, additional, Bryde, Robyn, additional, Gaballa, Andrew, additional, Ali, Adel H, additional, Mehra, Nandini, additional, Krumholz, Harlan M., additional, Sen, Sounok, additional, Kramer, Christopher M, additional, Martinez, Matthew W, additional, Desai, Milind Y, additional, Oikonomou, Evangelos K, additional, and Khera, Rohan, additional

Published
2024
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137. Developmental or Procedural Vena Cava Interruption and Venous Thromboembolism: A Review

Author

Bikdeli, Behnood, additional, Sadeghipour, Parham, additional, Lou, Junyang, additional, Bejjani, Antoine, additional, Khairani, Candrika D., additional, Rashedi, Sina, additional, Lookstein, Robert, additional, Lansky, Alexandra, additional, Vedantham, Suresh, additional, Sobieszczyk, Piotr, additional, Mena-Hurtado, Carlos, additional, Aghayev, Ayaz, additional, Henke, Peter, additional, Mehdipoor, Ghazaleh, additional, Tufano, Antonella, additional, Chatterjee, Saurav, additional, Middeldorp, Saskia, additional, Wasan, Suman, additional, Bashir, Riyaz, additional, Lang, Irene M., additional, Shishehbor, Mehdi H., additional, Gerhard-Herman, Marie, additional, Giri, Jay, additional, Menard, Matthew T., additional, Parikh, Sahil A., additional, Mazzolai, Lucia, additional, Moores, Lisa, additional, Monreal, Manuel, additional, Jimenez, David, additional, Goldhaber, Samuel Z., additional, Krumholz, Harlan M., additional, and Piazza, Gregory, additional

Published
2024
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139. Preprints for the life sciences

Author

Berg, Jeremy M, Bhalla, Needhi, Bourne, Philip E, Chalfie, Martin, Drubin, David G, Fraser, James S, Greider, Carol W, Hendricks, Michael, Jones, Chonnettia, Kiley, Robert, King, Susan, Kirschner, Marc W, Krumholz, Harlan M, Lehmann, Ruth, Leptin, Maria, Pulverer, Bernd, Rosenzweig, Brooke, Spiro, John E, Stebbins, Michael, Strasser, Carly, Swaminathan, Sowmya, Turner, Paul, Vale, Ronald D, VijayRaghavan, K, and Wolberger, Cynthia

Subjects
Philosophy and Religious Studies, History and Philosophy Of Specific Fields, Biological Science Disciplines, Information Dissemination, Publishing, General Science & Technology
Abstract

The time is right for biologists to post their research findings onto preprint servers

Published
2016

140. SCIENTIFIC COMMUNITY. Preprints for the life sciences.

Author

Berg, Jeremy M, Bhalla, Needhi, Bourne, Philip E, Chalfie, Martin, Drubin, David G, Fraser, James S, Greider, Carol W, Hendricks, Michael, Jones, Chonnettia, Kiley, Robert, King, Susan, Kirschner, Marc W, Krumholz, Harlan M, Lehmann, Ruth, Leptin, Maria, Pulverer, Bernd, Rosenzweig, Brooke, Spiro, John E, Stebbins, Michael, Strasser, Carly, Swaminathan, Sowmya, Turner, Paul, Vale, Ronald D, VijayRaghavan, K, and Wolberger, Cynthia

Subjects
Information Dissemination, Publishing, Biological Science Disciplines, General Science & Technology
Published
2016

141. The China Patient-Centred Evaluative Assessment of Cardiac Events (China PEACE)-Prospective Study of 3-Vessel Disease: rationale and design

Author

Rao, Chenfei, Bongiovanni, Tasce, Li, Xi, Gao, Huawei, Zhang, Heng, Li, Jing, Zhao, Yan, Yuan, Xin, Hua, Kun, Hu, Shengshou, Krumholz, Harlan M, Jiang, Lixin, and Zheng, Zhe

Subjects
Cardiovascular, Patient Safety, Prevention, Heart Disease, Clinical Research, Heart Disease - Coronary Heart Disease, Atherosclerosis, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Good Health and Well Being, China, Coronary Artery Bypass, Coronary Artery Disease, Drug-Eluting Stents, Guideline Adherence, Humans, Patient-Centered Care, Percutaneous Coronary Intervention, Practice Guidelines as Topic, Prospective Studies, Quality Improvement, Quality of Life, Treatment Outcome, China PEACE Collaborative Group, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Abstract

IntroductionComplex coronary artery disease (left main and three-vessel disease) carries high risks of adverse events and cost burden. However, in China, little is known about which patients are directed toward which treatment strategies and what outcomes are being achieved.Methods and analysisUsing the China PEACE (Patient-centered Evaluative Assessment of Cardiac Events) research network, this prospective study of three-Vessel Disease, the China PEACE-3VD study, has a plan to consecutively register over 4000 patients with a diagnosis of 3VD and/or left-main disease by elective coronary angiography at 24 large cardiovascular centres in China. We centrally conducted medical record abstraction and SYNTAX Score calculation for all registered patients. The sites invited patients to the prospective cohort, and conducted 1-year follow-up on major events, including cardiac events, symptoms, secondary prevention and quality of life. The estimated entire sample size of eligible patients of 4000 was determined based on both feasibility and consideration of adequate statistical precision for describing the treatment decisions, guidelines adherence and appropriateness of treatment for patients with complex coronary artery diseases. The study is designed to investigate patient, clinician and hospital factors associated with each treatment strategy (percutaneous coronary intervention, coronary artery bypass grafting or medical therapy) as well as appropriateness of treatment choice, current guideline compliance and patient-reported outcomes for patients with complex coronary artery disease in large cardiovascular centres in China, as a foundation for enhanced knowledge in the field and to assist quality improvement initiatives.Ethics and disseminationThe study protocol was approved by the ethics committee at the China National Center for Cardiovascular Diseases. Findings will be shared with participating hospitals, policymakers and the academic community, to promote quality monitoring, quality improvement and the efficient allocation, and use of coronary revascularisation procedures in China.Trial registration numberNCT01625312; Pre-results.

Published
2016

143. Characterisation of internal tremors and vibration symptoms

Author

Massey, Dorothy, primary, Sawano, Mitsuaki, additional, Baker, Anna D, additional, Güthe, Diana Berrent, additional, Güthe, Nick, additional, Shidlovsky, Suzanne Pincus, additional, Fisher, Liza, additional, Grady, Connor B, additional, Caraballo, Cesar, additional, Zhou, Tianna, additional, Sharma, Richa, additional, and Krumholz, Harlan M, additional

Published
2023
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147. Association of Neighborhood‐Level Material Deprivation with Adverse Outcomes and Processes of Care Among Patients with Heart Failure in a Single‐Payer Healthcare System: A Population‐Based Cohort Study

Author

Bobrowski, David, primary, Dorovenis, Andrew, additional, Abdel‐Qadir, Husam, additional, McNaughton, Candace D., additional, Alonzo, Rea, additional, Fang, Jiming, additional, Austin, Peter C., additional, Udell, Jacob A., additional, Jackevicius, Cynthia A., additional, Alter, David A., additional, Atzema, Clare L., additional, Bhatia, R. Sacha, additional, Booth, Gillian L., additional, Ha, Andrew C.T., additional, Johnston, Sharon, additional, Dhalla, Irfan, additional, Kapral, Moira K., additional, Krumholz, Harlan M., additional, Roifman, Idan, additional, Wijeysundera, Harindra C, additional, Ko, Dennis T., additional, Tu, Karen, additional, Ross, Heather J., additional, Schull, Michael J., additional, and Lee, Douglas S., additional

Published
2023
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150. Post-Vaccination Syndrome: A Descriptive Analysis of Reported Symptoms and Patient Experiences After Covid-19 Immunization

Author

Krumholz, Harlan M, primary, Wu, Yilun, additional, Sawano, Mitsuaki, additional, Shah, Rishi, additional, Zhou, Tianna, additional, Arun, Adith S, additional, Khosla, Pavan, additional, Kaleem, Shayaan, additional, Vashist, Anushree, additional, Bhattacharjee, Bornali, additional, Ding, Qinglan, additional, Lu, Yuan, additional, Caraballo, Cesar, additional, Warner, Frederick, additional, Huang, Chenxi, additional, Herrin, Jeph, additional, Putrino, David, additional, Hertz, Danice, additional, Dressen, Brianne, additional, and Iwasaki, Akiko, additional

Published
2023
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