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103. Können digitale Formulare die Patientenaufnahme in der Neurochirurgie verbessern?

Author

Polanski, Witold, Danker, Adrian, Zolal, Amir, Senf-Mothes, David, Schackert, Gabriele, and Krex, Dietmar

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Electronic health records (EHRs) are controversial but have the potential to improve patient care. We investigated whether a digital admission and assessment documentation form for neurosurgical patients may have an impact on the quality and duration of documentation of the neurosurgeons [for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019

104. Vergleich von Certoparin, Enoxaparin und Kompressionsstrümpfen zur thrombembolischen Prophylaxe bei neurochirurgischen Patienten

Author

Polanski, Witold, Krex, Dietmar, and Schackert, Gabriele

Subjects
ddc: 610, cardiovascular diseases, 610 Medical sciences, Medicine
Abstract

Objective: Postoperative thromboembolic events are a serious surgical complication and results most often in morbidity and mortality. In neurosurgical patients, the risk for venous thromboembolisms (VTE), including pulmonary embolism (PE) and deep venous thrombosis (DVT), is very high (range 0 to 5%)[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019

105. Radiologische Bewertung der Kontrastmittelanreicherung und des ,T2/FLAIR mismatch'-Signals in niedriggradigen Gliomen - eine Korrelation mit den molekularen Gruppen

Author

Juratli, Tareq, Tummala, Shilpa, Riedl, Angelika, Zolal, Amir, Thiede, Christian, Schackert, Gabriele, Krex, Dietmar, Miller, Julie, and Cahill, Daniel

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: With the updated World Health Organization (WHO) 2016 neuropathological diagnostic criteria, radiographic prognostic associations in lower-grade gliomas (LGG, WHO grade II and III) are undergoing re-evaluation. Methods: We identified 316 LGG patients (151 grade II and 165 grade III) [for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019

106. Long-term survival with glioblastoma multiforme

Author

Krex, Dietmar, Klink, Barbara, Hartmann, Christian, von Deimling, Andreas, Pietsch, Torsten, Simon, Matthias, Sabel, Michael, Steinbach, Joachim P., Heese, Oliver, Reifenberger, Guido, Weller, Michael, and Schackert, Gabriele

Published
2007

114. Contributors

Author

Aalbers, Marlien W., Abou-El-Hassan, Hadi, Acosta, Frank, Adelson, P. David, Adler, John R., Jr., Agarwal, Vijay, Aghi, Manish K., Ahluwalia, Manmeet S., Ahmed, A. Karim, Ajler, Pablo, Akinduro, Oluwaseun O., Albuquerque, Felipe C., Aldana, Philipp R., Alluri, Ram K., Alvi, Mohammed Ali, Amendola, Luca, Amin-Hanjani, Sepideh, Ammerman, Joshua M., Anderson, William, Andrade-Barazarte, Hugo, Appelboom, Geoff, Arnold, Paul M., Asthagiri, Ashok, Aulakh, Sonikpreet, Aziz, Khaled M., Aziz, Tipu, Bakhsheshian, Joshua, Ball, Perry A., Bandiera, Stefano, Barbaro, Nicholas M., Barnard, Zachary R., Barrow, Daniel L., Beaumont, Thomas L., Bederson, Joshua, Beier, Alexandra D., Bellabarba, Carlo, Bello, Lorenzo, Belzberg, Alan J., Ben-Haim, Sharona, Ben-Shalom, Netanel, Bender, Matthew T., Bendok, Bernard R., Benes, Ludwig, Benzel, Edward C., Bertalanffy, Helmut, Bettegowda, Chetan, Bhagat, Priyal Vinod, Bi, Wenya Linda, Bijanki, Kelly, Bishop, Allen T., Bisson, Erica F., Black, Keith L., Blondel, Benjamin, Boahene, Kofi, Bohnen, Angela M., Bollo, Robert J., Bookland, Markus, Borghei, Alireza, Borghei-Razavi, Hamid, Boriani, Stefano, Borkar, Sachin A., Bova, Frank J., Brahimaj, Bledi C., Brandt, Ryan J., Bransford, Richard J., Brotchi, Jacques, Brown, Benjamin L., Bruce, Jeffrey N., Bruneau, Michael, Buchanan, Ian A., Burchiel, Kim J., Burke, Timothy G., Bydon, Ali, Bydon, Mohamad, Byrne, Richard W., Cabral, Gustavo Augusto Porto Sereno, Cacciola, Francesco, Campos, Jessica K., Caplan, Justin M., Caputy, Anthony J., Cardinale, Francesco, Carlstrom, Lucas P., Carrau, Ricardo L., Carter, Bob S., Castana, Laura, Castillo-Velazquez, Gabriel, Chaichana, Kaisorn L., Chanan-Khan, Asher, Chang, Edward F., Chang, Steven D., Chari, Aswin, Chen, Ching-Jen, Chen, Douglas, Chen, James, Chen, Selby, Chern, Joshua J., Chi, John H., Chiocca, E. Antonio, Chitale, Rohan, Chitnavis, Bhupal, Choudhri, Omar A., Chu, Ray M., Clifton, William, Cohen, Alan R., Cohen, Salomon, Colby, Geoffrey P., Cole, Tyler S., Consales, Alessandro, Coon, Alexander L., Cooper, Jared B., Copeland, William R., Coric, Domagoj, Corl, Frank M., Corliss, Brian M., Corti, Marcelo, Cossu, Massimo, Currier, Bradford L., Curry, William T., Dabus, Guilherme, Dahdaleh, Nader S., Dailey, Andrew T., Daniels, David J., Dardis, Ronan M., Das, Sunit, Dasenbrock, Hormuzdiyar H., Day, Arthur L., Biase, Gaetano De, Garza Ramos, Rafael De la, Deen, H. Gordon, Deletis, Vedran, Detsky, Jay, Dlouhy, Brian J., Domingo, Ricardo A., Domino, Joseph, Donaldson, Angela M., Dornbos, David, Dorsi, Michael J., Reis, Cassius Vinicius Corrêa Dos, Ducker, Thomas B., Duffau, Hugues, Dunn, Ian F., D’Amico, Randy S., Eggenberger, Eric R., Ehresman, Jeff, El Naga, Ashraf N., Elarjani, Turki, Elder, Benjamin D., Elsharkawy, Ahmed, Epstein, Nancy E., Erkmen, Kadir, Errico, Thomas J., Eskey, Clifford J., Evans, Linton, Everson, Megan C., Fei, Naomi, Fessler, Richard G., Filler, Aaron G., Flores, Bruno C., Foley, Kevin T., Foroni, Roberto I., Forte, Antonio J., Fountas, Kostas N., Fox, W. Christopher, Freeman, William David, Friedman, William Alan, Frim, David M., Frisoli, Fabio, Fujimura, Miki, Ganaha, Sara, Gandhi, Dheeraj, Gandhi, Sirin, Garrett, Mark, Garzon-Muvdi, Tomas, Gasbarrini, Alessandro, Gassie, Kelly, Geisler, Fred H., Georgoulis, George, Gill, Brian J.A., Goehre, Felix, Goel, Atul, Goel, Gunjan, Gokaslan, Ziya L., Gold, Katherine G., Gomez, Diego F., Gonzalez, L. Fernando, Goodwin, C. Rory, Gordon, Chad R., Goyal, Anshit, Graffeo, C.S., Grande, Andrew W., Grandhi, Ramesh, Green, Alexander L., Greenfield, Jeffrey P., Grewal, Sanjeet S., Groves, Mari L., Guan, Jian, Guinto, Gerardo, Gullan, Richard, Gupta, Gaurav, Gupta, Nalin, Gupta, Vivek, Hah, Raymond J., Hakim, Fernando, Halalmeh, Dia Radi, Haldeman, Clayton L., Haranhalli, Neil, Hardesty, Douglas A., Hardigan, Trevor, Harrop, James S., Hartnett, Sara, Heinze, Stefan, Hernesniemi, Juha, Hersh, David S., Hidalgo, Joaquin, Hill, Travis, Hindoyan, Kevork N., Ho, Olivia, Hoh, Brian L., Hopkins, L. Nelson, Hsu, Wesley, Huang, Judy, Huang, Michael, Huff, Wei X., Huq, Sakibul, Hussain, Zain, Ironside, Natasha, Iyer, Rajiv R., Jabbour, Pascal M., Jackson, Christina, Jackson, Christopher M., Jahromi, Behnam Rezai, Jallo, George I., Jaume, Alejandra, Javadpour, Mohsen, Jea, Andrew, Jentoft, Mark, Jho, David H., Jho, Diana H., Jho, Hae-Dong, Jiang, Bowen, Joyce, Evan, Kalani, M. Yashar S., Kapsalaki, Eftychia Z., Kaplitt, Michael G., Karas, Patrick, Karatayli-Ozgursoy, Selmin, Kawase, Takeshi, Kehler, Uwe, Kerezoudis, Panagiotis, Kern, Drew S., Khan, Farhan A., Khan, Nickalus R., Khu, Kathleen, Kim, Daniel H., Kirsch, Matthias, Klinge, Petra, Koch, Matthew J., Kogan, Michael, Kolcun, John Paul G., Kondziolka, Douglas, Korinth, Marcus Christopher, Kotecha, Rupesh, Krex, Dietmar, Krishna, Chandan, Krishnan, Kartik G., Krishnaney, Ajit, Kshettry, Varun R., Lacy, Maureen, Ladner, Travis R., Landeiro, Jose Alberto, Lang, Frederick F., Lang, Michael J., Larsen, Alexandra Giantini, Laurent, Dimitri, Lawton, Michael T., Lee, Bryan S., Levi, Allan, Levivier, Marc, Levy, Elad I., Lim, Michael, Lin, Li-Mei, Lin, Michelle, Erland Lind, Göran, Linderoth, Bengt, Link, Michael J., Lo Russo, Giorgio, Loftus, Christopher M., Longhi, Michele, Lonser, Russell R., Louie, Christopher E., Lu, Daniel C., Ludtka, Christopher, Lundy, Larry B., Magge, Subu N., Malessy, Martijn J.A., Maniker, Allen H., Manley, Geoffrey T., Maralani, Peiman, Marenco-Hillembrand, Lina, Martinez-Sosa, Meleine, Mascitelli, Justin R., Mazur, Marcus D., McCormick, Paul C., Mena-Bernal, José Hinojosa, Menezes, Arnold H., Meyer, Fredric B., Middlebrooks, Erik H., Midha, Rajiv, Mikula, Anthony, Miller, David, Miller, Jonathan P., Mirza, Bilal, Mirzadeh, Zaman, Mocco, J., Molina, Camilo A., Montaser, Alaa S., Morcos, Jacques J., Morgan, Chad J., Mostofi, Abteen, Muftuoglu, Yagmur, Myrehaug, Sten, Nabavi, Arya, Nanaszko, Michael J., Nanda, Pranav, Naragum, Varun, Nasser, Rani, Nathal, Edgar, Nguyen, Timothy K., Nibali, Marco Conti, Nicolato, Antonio, Nimmagadda, Anitha, North, Richard B., Nottmeier, Eric, Noureldine, Mohammad Hassan A., Oakes, W. Jerry, Ogilvy, Christopher S., Ojemann, Jeffrey G., Ojemann, Steven, Okonkwo, David O., Olivi, Alessandro, Olomu, Osarenoma U., Orlev, Alon, Osburn, Brooks, Ota, Nakao, Otto, Bradley A., Pang, Dachling, Parney, Ian, Pascual, José María, Patel, Aman B., Patel, Anoop, Patel, Smruti K., Patir, Rana, Penn, Richard D., Pennington, Zachary, Pepa, Giuseppe Maria Della, Perdomo-Pantoja, Alexander, Pereira, Erlick A.C., Perez-Cruet, Mick J., Peris-Celda, Maria, Perry, A., Perry, Avital, Pessina, Federico, Peterson, Jennifer L., Pham, Martin H., Pichelmann, Mark, Pinheiro-Neto, Carlos D., Pirgousis, Phillip, Pitts, Lawrence H., Placide, Rick J., Plaha, Puneet, Polifka, Adam J., Pondaag, Willem, Post, Kalmon D., Potts, Matthew B., Poulsgaard, Lars, Prete, Alessandro, Prevedello, Daniel M., Prieto, Ruth, Puffer, Ross C., Quevedo-Valdes, Pablo A., Quiñones-Hinojosa, Alfredo, Quintana, Leonidas M., Sr., Rahmathulla, Gazanfar, Rahme, Rudy J., Ramhmdani, Seba, Ramon, Juan F., Ramos-Fresnedo, Andres, Ramos-Zuniga, Rodrigo, Sr., Ranalli, Nathan J., Ranjan, Manish, Rapp, Aaron, Ravindra, Vijay M., Recinos, Pablo F., ReFaey, Karim, Régis, Jean, Relyea, Katherine, Resnick, Daniel K., Richardson, Angela M., Rigamonti, Daniele, Riva, Marco, Riva, Matteo, Rizzi, Michele, Rochkind, Shimon, Rolston, John D., Rosenberg, William S., Rosenwasser, Robert H., Roser, Florian, Rossi, Marco, Rowland, Nathan C., Rutka, James T., Rymarczuk, George N., Sahgal, Arjun, Sala, Francesco, Salle, Federico, Sani, Sepehr, Santiago, Gabriel F., Salvatori, Roberto, Martinez Santos, Jaime L., Sarris, Christina E., Savastano, Luis E., Saxena, Amar, Schackert, Gabriele, Prof, Schmidt, Meic H., Schroeder, Henry W.S., Prof, Schwab, Joseph, Schwartz, Theodore H., Sciortino, Tommaso, Sciubba, Daniel M., Scott, Kyle W., Scoville, Jonathan P., See, Alfred P., Sekula, Raymond F., Jr., Shad, Amjad, Shah, Jugal, Shaibani, Ali, Shaikhouni, Ammar, Sharma, Manish S., Sheehan, Jason, Sheehy, John Paul, Sheth, Sameer, Shi, Changbin, Shimony, Nir, Shin, Alexander Y., Siddiqui, Adnan H., Silveira, Roberto Leal, Simmons, Nathan, Sindou, Marc, Sinisi, Marco, Smith, Edward R., Smith, Joseph R., Smith, Kyle A., Smyth, Matthew D., Soliman, Hany, Souweidane, Mark M., Spagnuolo, Edgardo, Spetzler, Robert F., Spinner, Robert J., Stapleton, Christopher J., Stein, Rachel, Steinmetz, Michael P., Stone, Scellig, Stricsek, Geoffrey P., Suarez-Meade, Paola, Sughrue, Michael E., Suk, Ian, Sun, Daniel Q., Sur, Samir, Sure, Ulrich, Sweid, Ahmad, Tafel, Ian, Tamargo, Rafael J., Tawk, Rabih G., Tew, John M., Jr., Theodore, Nicholas, Thompson, B. Gregory, Jr., Thompson, John A., Tian, Fucheng, Tirakotai, Wuttipong, Tjoumakaris, Stavropoula, Todnem, Nathan, Tominaga, Teiji, Trifiletti, Daniel M., Tripathi, Shashwat, Tseng, Eric, Tubbs, R. Shane, Tulamo, Riikka, Tuleasca, Constantin, Turkmani, Ali H., Vakharia, Kunal, Van Gompel, Jamie J., Vasudeva, Viren S., Velasco, Ana Luisa, Velasco, Francisco, Velat, Gregory J., Venur, Vyshak Alva, Verlicchi, Angela, Vivas-Buitrago, Tito, Vlasak, Alexander L., Vrionis, Frank D., Wainwright, John Varmaa, Wallace, M. Christopher, Waqas, Muhammad, Watridge, Clarence B., Weiss, Nirit, Welz, Matthew E., Westbroek, Erick M., Wharen, Robert E., Wildrick, David M., Wilkinson, D. Andrew, Winfree, Christopher J., Witham, Timothy, Wolff, Amir, Wolinsky, Jean-Paul, Wu, Kyle C., Xavier, Shaun, Yaeger, Kurt, Yampolsky, Claudio, Yassari, Reza, Yolcu, Yagiz Ugur, Yu, Alexander K., Zager, Eric L., Zanotti, Bruno, Zileli, Mehmet, and Zivelonghi, Emanuele

Published
2022
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115. MGMT promoter methylation analysis for allocating combined CCNU/TMZ chemotherapy: Lessons learned from the CeTeG/NOA‐09 trial.

Author

Tzaridis, Theophilos, Schäfer, Niklas, Weller, Johannes, Steinbach, Joachim‐Peter, Schlegel, Uwe, Seidel, Sabine, Sabel, Michael, Hau, Peter, Seidel, Clemens, Krex, Dietmar, Goldbrunner, Roland, Tonn, Jörg‐Christian, Grauer, Oliver, Kebir, Sied, Schneider, Matthias, Schaub, Christina, Vatter, Hartmut, Coch, Christoph, Glas, Martin, and Fimmers, Rolf

Subjects
METHYLATION, DNA repair, DNA methylation, PROGNOSIS, LOG-rank test
Abstract

The CeTeG/NOA‐09 trial showed a survival benefit for combined CCNU/TMZ therapy in MGMT‐promoter‐methylated glioblastoma patients (quantitative methylation‐specific PCR [qMSP] ratio > 2). Here, we report on the prognostic value of the MGMT promoter methylation ratio determined by qMSP and evaluate the concordance of MGMT methylation results obtained by qMSP, pyrosequencing (PSQ) or DNA methylation arrays (MGMT‐STP27). A potential association of qMSP ratio with survival was analyzed in the CeTeG/NOA‐09 trial population (n = 129; log‐rank tests, Cox regression analyses). The concordance of MGMT methylation assays (qMSP, PSQ and MGMT‐STP27) was evaluated in 76 screened patients. Patients with tumors of qMSP ratio > 4 showed superior survival compared to those with ratios 2‐4 (P =.0251, log‐rank test). In multivariate analysis, the qMSP ratio was not prognostic across the study cohort (hazard ratio [HR] = 0.88; 95% CI: 0.72‐1.08). With different cutoffs for qMSP ratio (4, 9, 12 or 25), the CCNU/TMZ benefit tended to be larger in subgroups with lower ratios (eg, for cutoff 9: HR 0.32 for lower subgroup, 0.73 for higher subgroup). The concordance rates with qMSP were 94.4% (PSQ) and 90.2% (MGMT‐STP27). Discordant results were restricted to tumors with qMSP ratios ≤4 and PSQ mean methylation rate ≤25%. Despite a shorter survival in MGMT‐promoter‐methylated patients with lower methylation according to qMSP, these patients had a benefit from combined CCNU/TMZ therapy, which even tended to be stronger than in patients with higher methylation rates. With acceptable concordance rates, decisions on CCNU/TMZ therapy may also be based on PSQ or MGMT‐STP27. What's new? In patients with IDH‐wildtype glioblastoma, methylation of the MGMT promoter allows for improved survival after chemotherapy, due to reduced ability to repair DNA damage. Here, the authors set out to evaluate the use of different tests for promoter methylation, with an eye toward their usefulness at allocation of chemotherapy, and on their prognostic applicability. They show that three different methods of testing methylation—quantitative methylation‐specific PCR, pyrosequencing, and DNA methylation arrays—agree more than 90% of the time. Patients with lower MGMT promoter methylation had shorter survival times, but still benefited from CCNU/TMZ therapy. [ABSTRACT FROM AUTHOR]

Published
2021
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116. Clinical impact of TERT promoter mutation detection in cell-free DNA of patients with IDH wild-type glioblastomas - a pilot prospective study

Author

Krex, Dietmar, Juratli, Tareq, Juratli, Mazen, Makina, Meriem, Schackert, Gabriele, Lautenschlaeger, Tim, and Thiede, Christian

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Detection ofcirculatingcell-free tumor-derivedDNA(cfDNA) has been shown to be of clinical value in monitoring cancer treatment. We conducted a pilot study on the feasibility of detecting TERT promoter TERTp-mutant cfDNA in CSF and plasma in glioblastoma patients and its potential clinical[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Published
2018

117. Molecular characterization of multifocal glioblastomas

Author

Krex, Dietmar, Temme, Achim, Schackert, Gabriele, Klink, Barbara, and Abou-El-Ardat, Khalil

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Multifocal glioblastoma, i.e. multiple synchronous lesions in one patient, are considered to be a good model to elucidate the pathogenesis and progression of malignant gliomas. Our aim was to perform a molecular characterization of a small set of this tumor entity. Methods: Tumor tissue[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Published
2018

118. Efficacy of Tumor Treating Fields (TTFields) and aurora B kinase inhibitor in glioma cells

Author

Krex, Dietmar, Temme, Achim, Schneidermann, Rosa, Giladi, Moshe, Kinzel, Adrian, Kirson, Eilon, and Palti, Yoram

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Tumor Treating Fields (TTFields) are an effective anti-neoplastic treatment modality delivered via noninvasive application of low intensity, intermediate frequency, alternating electric fields. A promising approach to enhance the efficiency of TTFields is the use of drugs which extend metaphase-anaphase[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Published
2018

121. Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA–09): a randomised, open-label, phase 3 trial

Author

Herrlinger, Ulrich, primary, Tzaridis, Theophilos, additional, Mack, Frederic, additional, Steinbach, Joachim Peter, additional, Schlegel, Uwe, additional, Sabel, Michael, additional, Hau, Peter, additional, Kortmann, Rolf-Dieter, additional, Krex, Dietmar, additional, Grauer, Oliver, additional, Goldbrunner, Roland, additional, Schnell, Oliver, additional, Bähr, Oliver, additional, Uhl, Martin, additional, Seidel, Clemens, additional, Tabatabai, Ghazaleh, additional, Kowalski, Thomas, additional, Ringel, Florian, additional, Schmidt-Graf, Friederike, additional, Suchorska, Bogdana, additional, Brehmer, Stefanie, additional, Weyerbrock, Astrid, additional, Renovanz, Miriam, additional, Bullinger, Lars, additional, Galldiks, Norbert, additional, Vajkoczy, Peter, additional, Misch, Martin, additional, Vatter, Hartmut, additional, Stuplich, Moritz, additional, Schäfer, Niklas, additional, Kebir, Sied, additional, Weller, Johannes, additional, Schaub, Christina, additional, Stummer, Walter, additional, Tonn, Jörg-Christian, additional, Simon, Matthias, additional, Keil, Vera C, additional, Nelles, Michael, additional, Urbach, Horst, additional, Coenen, Martin, additional, Wick, Wolfgang, additional, Weller, Michael, additional, Fimmers, Rolf, additional, Schmid, Matthias, additional, Hattingen, Elke, additional, Pietsch, Torsten, additional, Coch, Christoph, additional, and Glas, Martin, additional

Published
2019
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122. MOLECULAR GENETIC, HOST-DERIVED AND CLINICAL DETERMINANTS OF LONG-TERM SURVIVAL IN GLIOBLASTOMA: FIRST RESULTS FROM THE BRAIN TUMOR FUNDERS' COLLABORATIVE CONSORTIUM

Author

Happold, Caroline, Felsberg, Joerg, Clarke, Jennifer, Soffietti, Riccardo, Marosi, Christine, Krex, Dietmar, Ducray, Francois, Hau, Peter, Reijneveld, Jaap, Weyerbrock, Astrid, Wick, Antje, Reardon, David, Glas, Martin, Razis, Evangelia, Herrlinger, Ulrich, Tonn, Joerg-Christian, Carpentier, Antoine F., Lefranc, Florence, Le Rhun, Emilie, Verschuere, Tina, Golfinopoulos, Vassilis, Klein, Martin, Reifenberger, Guido, Weller, Michael, Neurology, CCA - Imaging and biomarkers, CCA - Cancer Treatment and quality of life, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, NCA - Neurobiology of mental health, and Medical psychology

Published
2017

123. Radiographic assessment of contrast enhancement and T2/FLAIR mismatch sign in lower grade gliomas: correlation with molecular groups

Author

Juratli, Tareq A., primary, Tummala, Shilpa S., additional, Riedl, Angelika, additional, Daubner, Dirk, additional, Hennig, Silke, additional, Penson, Tristan, additional, Zolal, Amir, additional, Thiede, Christian, additional, Schackert, Gabriele, additional, Krex, Dietmar, additional, Miller, Julie J., additional, and Cahill, Daniel P., additional

Published
2018
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124. TERT Promoter Mutation Detection in Cell-Free Tumor-Derived DNA in Patients with IDH Wild-Type Glioblastomas: A Pilot Prospective Study

Author

Juratli, Tareq A., primary, Stasik, Sebastian, additional, Zolal, Amir, additional, Schuster, Caroline, additional, Richter, Sven, additional, Daubner, Dirk, additional, Juratli, Mazen A., additional, Thowe, Rachel, additional, Hennig, Silke, additional, Makina, Meriem, additional, Meinhardt, Matthias, additional, Lautenschlaeger, Tim, additional, Schackert, Gabriele, additional, Krex, Dietmar, additional, and Thiede, Christian, additional

Published
2018
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125. ATIM-33. NOA-16: A FIRST-IN-MAN MULTICENTER PHASE I CLINICAL TRIAL OF THE GERMAN NEUROONCOLOGY WORKING GROUP EVALUATING A MUTATION-SPECIFIC PEPTIDE VACCINE TARGETING IDH1R132H IN PATIENTS WITH NEWLY DIAGNOSED MALIGNANT ASTROCYTOMAS

Author

Platten, Michael, primary, Schilling, Daniela, additional, Bunse, Lukas, additional, Wick, Antje, additional, Bunse, Theresa, additional, Riehl, Dennis, additional, Green, Edward, additional, Sanghvi, Khwab, additional, Karapanagiotou-Schenkel, Irini, additional, Harting, Inga, additional, Sahm, Felix, additional, Steinbach, Joachim, additional, Weyerbrock, Astrid, additional, Hense, Jörg, additional, Misch, Martin, additional, Krex, Dietmar, additional, Stevanovic, Stefan, additional, Tabatabai, Ghazaleh, additional, von Deimling, Andreas, additional, Schmitt, Michael, additional, and Wick, Wolfgang, additional

Published
2018
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126. QOLP-20. QUALITY OF LIFE IN THE PHASE III CeTeG/NOA-09 TRIAL RANDOMIZING CCNU/TEMOZOLOMIDE (TMZ) COMBINATION THERAPY VS. STANDARD TMZ THERAPY FOR NEWLY DIAGNOSED MGMT-METHYLATED GLIOBLASTOMA

Author

Weller, Johannes, primary, Tzaridis, Theophilos, additional, Steinbach, Joachim, additional, Schlegel, Uwe, additional, Hau, Peter, additional, Krex, Dietmar, additional, Grauer, Oliver, additional, Goldbrunner, Roland, additional, Bähr, Oliver, additional, Uhl, Martin, additional, Seidel, Clemens, additional, Tabatabai, Ghazaleh, additional, Bullinger, Lars, additional, Galldiks, Norbert, additional, Schaub, Christina, additional, Stummer, Walter, additional, Simon, Matthias, additional, Fimmers, Rolf, additional, Matthias, Schmid, additional, Coch, Christoph, additional, Glas, Martin, additional, Herrlinger, Ulrich, additional, and Schäfer, Niklas, additional

Published
2018
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131. Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the IDH1 Mutation Status

Author

Uckermann, Ortrud, primary, Juratli, Tareq A., additional, Galli, Roberta, additional, Conde, Marina, additional, Wiedemuth, Ralf, additional, Krex, Dietmar, additional, Geiger, Kathrin, additional, Temme, Achim, additional, Schackert, Gabriele, additional, Koch, Edmund, additional, Steiner, Gerald, additional, and Kirsch, Matthias, additional

Published
2018
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132. A mutation-specific peptide vaccine targeting IDH1R132H in patients with newly diagnosed malignant astrocytomas: A first-in-man multicenter phase I clinical trial of the German Neurooncology Working Group (NOA-16).

Author

Platten, Michael, primary, Schilling, Daniela, additional, Bunse, Lukas, additional, Wick, Antje, additional, Bunse, Theresa, additional, Riehl, Dennis, additional, Karapanagiotou-Schenkel, Irini, additional, Harting, Inga, additional, Sahm, Felix, additional, Schmitt, Anita, additional, Steinbach, Joachim Peter, additional, Weyerbrock, Astrid, additional, Hense, Jörg, additional, Misch, Martin, additional, Krex, Dietmar, additional, Stevanovic, Stefan, additional, Tabatabai, Ghazaleh, additional, von Deimling, Andreas, additional, Schmitt, Michael, additional, and Wick, Wolfgang, additional

Published
2018
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133. Intratumoral heterogeneity and TERT promoter mutations in progressive/higher-grade meningiomas

Author

Juratli, Tareq A., primary, Thiede, Christian, additional, Koerner, Mara V.A., additional, Tummala, Shilpa S., additional, Daubner, Dirk, additional, Shankar, Ganesh M., additional, Williams, Erik A., additional, Martinez-Lage, Maria, additional, Soucek, Silke, additional, Robel, Katja, additional, Penson, Tristan, additional, Krause, Mechthild, additional, Appold, Steffen, additional, Meinhardt, Matthias, additional, Pinzer, Thomas, additional, Miller, Julie J., additional, Krex, Dietmar, additional, Ely, Heather A., additional, Silverman, Ian M., additional, Christiansen, Jason, additional, Schackert, Gabriele, additional, Wakimoto, Hiroaki, additional, Kirsch, Matthias, additional, Brastianos, Priscilla K., additional, and Cahill, Daniel P., additional

Published
2017
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134. Quality of life in the GLARIUS trial randomizing bevacizumab/irinotecan versus temozolomide in newly diagnosed, MGMT-nonmethylated glioblastoma

Author

Schäfer, Niklas, primary, Proescholdt, Martin, additional, Steinbach, Joachim P, additional, Weyerbrock, Astrid, additional, Hau, Peter, additional, Grauer, Oliver, additional, Goldbrunner, Roland, additional, Friedrich, Franziska, additional, Rohde, Veit, additional, Ringel, Florian, additional, Schlegel, Uwe, additional, Sabel, Michael, additional, Ronellenfitsch, Michael W, additional, Uhl, Martin, additional, Grau, Stefan, additional, Hänel, Mathias, additional, Schnell, Oliver, additional, Krex, Dietmar, additional, Vajkoczy, Peter, additional, Tabatabai, Ghazaleh, additional, Mack, Frederic, additional, Schaub, Christina, additional, Tzaridis, Theophilos, additional, Nießen, Michael, additional, Kebir, Sied, additional, Leutgeb, Barbara, additional, Urbach, Horst, additional, Belka, Claus, additional, Stummer, Walter, additional, Glas, Martin, additional, and Herrlinger, Ulrich, additional

Published
2017
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135. ACTR-58. PHASE III TRIAL OF CCNU/TEMOZOLOMIDE (TMZ) COMBINATION THERAPY VS. STANDARD TMZ THERAPY FOR NEWLY DIAGNOSED MGMT-METHYLATED GLIOBLASTOMA PATIENTS: THE CeTeg/NOA-09 trial

Author

Herrlinger, Ulrich, primary, Tzaridis, Theophilos, additional, Mack, Frederic, additional, Steinbach, Joachim, additional, Schlegel, Uwe, additional, Sabel, Michael, additional, Hau, Peter, additional, Kortman, Rolf-Dieter, additional, Krex, Dietmar, additional, Grauer, Oliver, additional, Goldbrunner, Roland, additional, Schnell, Oliver, additional, Baehr, Oliver, additional, Uhl, Martin, additional, Tabatabai, Ghazaleh, additional, Ringel, Florian, additional, Schmidt-Graf, Friederike, additional, Brehmer, Stefanie, additional, Weyerbrock, Astrid, additional, Bullinger, Lars, additional, Vajkoczy, Peter, additional, Vatter, Hartmut, additional, Schäfer, Niklas, additional, Kebir, Sied, additional, Weller, Johannes, additional, Stummer, Walter, additional, Simon, Matthias, additional, Keil, Vera, additional, Nelles, Michael, additional, Fimmers, Rolf, additional, Pietsch, Torsten, additional, Hattingen, Elke, additional, Coch, Christoph, additional, and Glas, Martin, additional

Published
2017
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138. Preliminary study on the clinical application of the new VP Reveal system in brain tumor surgery

Author

Juratli, Tareq A., Zolal, Amir, Schackert, Gabriele, and Krex, Dietmar

Subjects
VP Reveal, brain tumor surgery, ddc: 610, 610 Medical sciences, Medicine, virtual reality system
Abstract

Objective: VP Reveal (Vesalius Perfectus, Eindhoven, The Netherlands) is a commercially available “virtual reality” system designed to generate and review stereoscopic 3D models of any DICOM based CT, MRI, MRA, PET-scan within seconds. The system uses polarized 3D glasses and a 3D monitor.[for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Published
2016
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139. Additional file 1: Table S1 of Chemotherapy for intracranial ependymoma in adults

Author

Gramatzki, Dorothee, Roth, Patrick, JĂśrg Felsberg, Hofer, Silvia, Rushing, Elisabeth, Hentschel, Bettina, Westphal, Manfred, Krex, Dietmar, Simon, Matthias, Schnell, Oliver, Wick, Wolfgang, Reifenberger, Guido, and Weller, Michael

Subjects
neoplasms
Abstract

Association of age, tumor localization, gender, KPS and MGMT promoter methylation status with survival (nâ =â 15, patients 5 and 9 excluded°). (PDF 82 kb)

Published
2016
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140. Bevacizumab Plus irinotecan versus temozolomide in newly diagnosed O⁶-methylguanine-DNA methyltransferase nonmethylated glioblastoma : The randomized GLARIUS trial

Author

Herrlinger, Ulrich, Schäfer, Niklas, Steinbach, Joachim P., Weyerbrock, Astrid, Hau, Peter, Goldbrunner, Roland, Friedrich, Franziska, Rohde, Veit, Ringel, Florian, Schlegel, Uwe, Sabel, Michael, Ronellenfitsch, Michael W., Uhl, Martin, Maciaczyk, Jaroslaw, Grau, Stefan, Schnell, Oliver, Hänel, Mathias, Krex, Dietmar, Vajkoczy, Peter, Gerlach, Rudiger, Kortmann, Rolf-Dieter, Mehdorn, Maximilian, Tuttenberg, Jochen, Mayer-Steinacker, Regine, Fietkau, Rainer, Brehmer, Stefanie, Mack, Frederic, Stuplich, Moritz, Kebir, Sied, Kohnen, Ralf, Dunkl, Elmar, Leutgeb, Barbara, Proescholdt, Martin, Pietsch, Torsten, Urbach, Horst, Belka, Claus, Stummer, Walter, and Glas, Martin

Subjects
Medizin
Published
2016

142. Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation

Author

Kessler, Tobias, primary, Sahm, Felix, additional, Sadik, Ahmed, additional, Stichel, Damian, additional, Hertenstein, Anne, additional, Reifenberger, Guido, additional, Zacher, Angela, additional, Sabel, Michael, additional, Tabatabai, Ghazaleh, additional, Steinbach, Joachim, additional, Sure, Ulrich, additional, Krex, Dietmar, additional, Grosu, Anca-L, additional, Bewerunge-Hudler, Melanie, additional, Jones, David, additional, Pfister, Stefan M, additional, Weller, Michael, additional, Opitz, Christiane, additional, Bendszus, Martin, additional, von Deimling, Andreas, additional, Platten, Michael, additional, and Wick, Wolfgang, additional

Published
2017
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144. Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas

Author

Abou-El-Ardat, Khalil, primary, Seifert, Michael, additional, Becker, Kerstin, additional, Eisenreich, Sophie, additional, Lehmann, Matthias, additional, Hackmann, Karl, additional, Rump, Andreas, additional, Meijer, Gerrit, additional, Carvalho, Beatriz, additional, Temme, Achim, additional, Schackert, Gabriele, additional, Schröck, Evelin, additional, Krex, Dietmar, additional, and Klink, Barbara, additional

Published
2017
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146. Improved prognostic stratification of patients with diffuse cerebral WHO grade II and III gliomas using genome- and transcriptome-wide molecular profiling

Author

Reifenberger, Guido, Weber, Ruthild G., Willscher, Edith, Riehmer, Vera, Hentschel, Bettina, Kreuz, Markus, Felsberg, Jörg, Beyer, Ulrike, Löffler-Wirth, Henry, Kaulich, Kerstin, Steinbach, Joachim, Hartmann, Christian, Gramatzki, Dorothee, Schramm, Johannes, Westphal, Manfred, Schackert, Gabriele, Simon, Matthias, Martens, Tobias, Boström, Jan, Hagel, Christian, Sabel, Michael, Krex, Dietmar, Tonn, Jörg C., Wolfgang, Wick, Noell, Susan, Schlegel, Uwe, Radlwimmer, Bernhard, Pietsch, Torsten, Loeffler, Markus, Von Deimling, Andreas, Binder, Hans, Weller, Michael, and Network, German Glioma

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction and objectives: Classification of cerebral gliomas of WHO grades II and III is associated with considerable interobserver variability. We evaluated whether genomic and transcriptomic profiling can improve stratification of patients with diffuse and anaplastic gliomas into prognostically[for full text, please go to the a.m. URL], 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)

Published
2015

148. Radio-chemotherapy improves survival for IDH mutant, 1p/19q non-codeleted secondary high-grade astrocytoma

Author

Juratli, Tareq A., Geiger, Kathrin D., Pinzer, Thomas, Krause, Mechthild, Lautenschläger, Tim, Schackert, Gabriele, and Krex, Dietmar

Subjects
ddc: 610, radio-chemotherapy, secondary high-grade astrocyto, 610 Medical sciences, Medicine, neoplasms, IDH mutation
Abstract

Objective: To evaluate the treatment efficacy in patients with IDH mutant, 1p/19q non-codeleted secondary high-grade astrocytoma (sHGA) WHO grades III/ IV. Method: Clinical data of 109 sHGA patients grades III/IV, in addition toIDH mutation-, 1p/19q-codeletion- and MGMT-promoter[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2015

149. Radiographic assessment of contrast enhancement and T2/FLAIR mismatch sign in lower grade gliomas: correlation with molecular groups.

Author

Juratli, Tareq A., Tummala, Shilpa S., Riedl, Angelika, Daubner, Dirk, Hennig, Silke, Penson, Tristan, Zolal, Amir, Thiede, Christian, Schackert, Gabriele, Krex, Dietmar, Miller, Julie J., and Cahill, Daniel P.

Abstract

Purpose: With the updated World Health Organization (WHO) 2016 neuropathological diagnostic criteria, radiographic prognostic associations in lower-grade gliomas (LGG, WHO grade II and III) are undergoing re-evaluation.Methods: We identified 316 LGG patients (151 grade II and 165 grade III) for a combined cohort from three independent databases. We analyzed the preoperative axial FLAIR, axial T2-weighted and post-gadolinium volumetric T1-weighted MR images. The molecular data collected included the status of IDH1/2, TP53, TERT promoter and ATRX mutations, in addition to 1p/19q co-deletions. In a subset of cases (n = 133), we assessed the "T2-FLAIR mismatch" sign.Results: Gliomas were assigned to one of the three molecular groups: Group O (IDH-mutant, 1p/19q co-deleted oligodendrogliomas, n = 95), Group A (IDH-mutant, ATRX inactivated astrocytomas, n = 175) and Group G (IDH wild-type, GBM-like, n = 46). A contrast-enhancing tumor was seen in 98 patients (31%), most frequently in Group G (n = 28/45, 57%), when compared to Group A (n = 49/175, 28%) and Group O (n = 24/95, 25.3%) tumors (p = 0.008 and p = 0.0011, respectively). Consistent with previous reports, T2-FLAIR mismatch was preferentially found in Group A tumors (73.1%, 60 of 82), although its presence was not associated with survival, after controlling for molecular group. False positive mismatch sign was noted in 28.5% (12/42) Group O tumors, but none of the tumors in Group G. A combination of all three factors: age under 40 years at first diagnosis, a tumor size larger than 6 cm and T2-FLAIR mismatch was highly specific for IDH mutant astrocytoma (Group A).Conclusion: We identify radiographic correlates of molecular groups in lower-grade gliomas, which join clinical demographic features in defining the characteristic presentation of these tumors. Radiographic correlates of prognosis in LGG require re-evaluation within molecular group. [ABSTRACT FROM AUTHOR]

Published
2019
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150. Abstract LB-362: A six-gene classifier stratifies low-grade glioma patients with wild-type IDH

Author

Huebner, Alexander, primary, Oehlke, Oliver, additional, Juratli, Tareq A., additional, Meng, Wei, additional, Ibrahim, Ahmed, additional, Li, Bin, additional, Erny, Daniel, additional, Robe, Pierre, additional, Krex, Dietmar, additional, Schackert, Gabriele, additional, Prinz, Marco, additional, Grosu, Anca, additional, and Chakravarti, Arnab, additional

Published
2016
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