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103. Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia

Author

Raymond, Andrea D, primary, Gekonge, Bethsebah, additional, Giri, Malavika S, additional, Hancock, Aidan, additional, Papasavvas, Emmanouil, additional, Chehimi, Jihed, additional, Kossevkov, Andrew V, additional, Nicols, Calen, additional, Yousef, Malik, additional, Mounzer, Karam, additional, Shull, Jane, additional, Kostman, Jay, additional, Showe, Louise, additional, and Montaner, Luis J, additional

Published
2010
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106. Inability of Plasmacytoid Dendritic Cells To Directly Lyse HIV-Infected Autologous CD4 + T Cells despite Induction of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

Author

Chehimi, Jihed, primary, Papasavvas, Emmanouil, additional, Tomescu, Costin, additional, Gekonge, Bethsebah, additional, Abdulhaqq, Shaheed, additional, Raymond, Andrea, additional, Hancock, Aidan, additional, Vinekar, Kavita, additional, Carty, Craig, additional, Reynolds, Griffin, additional, Pistilli, Maxwell, additional, Mounzer, Karam, additional, Kostman, Jay, additional, and Montaner, Luis J., additional

Published
2010
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108. Circulating Monocytes in HIV-1-Infected Viremic Subjects Exhibit an Antiapoptosis Gene Signature and Virus- and Host-Mediated Apoptosis Resistance

Author

Giri, Malavika S., primary, Nebozyhn, Michael, additional, Raymond, Andrea, additional, Gekonge, Bethsebah, additional, Hancock, Aidan, additional, Creer, Shenoa, additional, Nicols, Calen, additional, Yousef, Malik, additional, Foulkes, Andrea S., additional, Mounzer, Karam, additional, Shull, Jane, additional, Silvestri, Guido, additional, Kostman, Jay, additional, Collman, Ronald G., additional, Showe, Louise, additional, and Montaner, Luis J., additional

Published
2009
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112. Short Communication: HIV Type 1 Viremia on ART Is Positively Associated with Polyclonal T Cell Proliferation in Subjects with T Cell IFN-γ Secretion Levels Comparable to Those of Uninfected Subjects

Author

Papasavvas, Emmanouil, primary, Moore, Elizabeth C., additional, Sun, Junwei, additional, Azzoni, Livio, additional, Pistilli, Maxwell, additional, Mounzer, Karam, additional, Shull, Jane, additional, Kostman, Jay R., additional, and Montaner, Luis J., additional

Published
2008
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113. Baseline Viral Load and Immune Activation Determine the Extent of Reconstitution of Innate Immune Effectors in HIV-1-Infected Subjects Undergoing Antiretroviral Treatment

Author

Chehimi, Jihed, primary, Azzoni, Livio, additional, Farabaugh, Matthew, additional, Creer, Shenoa A., additional, Tomescu, Costin, additional, Hancock, Aidan, additional, Mackiewicz, Agnes, additional, D’Alessandro, Lara, additional, Ghanekar, Smita, additional, Foulkes, Andrea S., additional, Mounzer, Karam, additional, Kostman, Jay, additional, and Montaner, Luis J., additional

Published
2007
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115. Prevalence, Risk Factors, and Outcomes for Occult Hepatitis B Virus Infection Among HIV-Infected Patients

Author

Re, Vincent Lo, primary, Frank, Ian, additional, Gross, Robert, additional, Dockter, Janel, additional, Linnen, Jeffrey M, additional, Giachetti, Cristina, additional, Tebas, Pablo, additional, Stern, John, additional, Synnestvedt, Marie, additional, Localio, A Russell, additional, Kostman, Jay R, additional, and Strom, Brian L, additional

Published
2007
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116. Protection Against Chlamydia trachomatis Infection and Upper Genital Tract Pathological Changes by Vaccine-Promoted Neutralizing Antibodies Directed to the VD4 of the Major Outer Membrane Protein.

Author

Lo Re III, Vincent, Lynn, Kenneth, Stumm, Emily R., Jin Long, Nezamzadeh, Melissa S., Baker, Joshua F., Hoofnagle, Andrew N., Kapalko, Angela J., Mounzer, Karam, Zemel, Babette S., Tebas, Pablo, Kostman, Jay R., and Leonard, Mary B.

Subjects
BONE abnormalities, HIV infections, HEPATITIS C virus, BONE density, BONE fractures, DISEASES in women
Abstract

The VD4 region from the Chlamydia trachomatis major outer membrane protein contains important neutralizing B-cell epitopes of relevance for antibody-mediated protection against genital tract infection. We developed a multivalent vaccine construct based on VD4s and their surrounding constant segments from serovars D, E, and F. Adjuvanted with cationic liposomes, this construct promoted strong immune responses to serovar-specific epitopes, the conserved LNPTIAG epitope and neutralized serovars D, E, and F. Vaccinated mice were protected against challenge, with protection defined as reduced bacterial numbers in vagina and prevention of pathological changes in the upper genital tract. Adoptive transfer of serumand T-cell depletion experiments demonstrated a dominant role for antibodies and CD4+ T cells in the protective immune response. Integrating a multivalent VD4 construct into the sequence of the major outer membrane protein resulted in a protective and broadly neutralizing vaccine. Our findings emphasize the important role of antibodies in protection against Chlamydia trachomatis. [ABSTRACT FROM AUTHOR]

Published
2015
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117. Plasmacytoid dendritic cell and functional HIV Gag p55-specific T cells before treatment interruption can inform set-point plasma HIV viral load after treatment interruption in chronically suppressed HIV-1+ patients.

Author

Papasavvas, Emmanouil, Foulkes, Andrea, Yin, Xiangfan, Joseph, Jocelin, Ross, Brian, Azzoni, Livio, Kostman, Jay R., Mounzer, Karam, Shull, Jane, and Montaner, Luis J.

Subjects
DENDRITIC cells, STATISTICAL correlation, T cells, ANTIRETROVIRAL agents, HIV infections, THERAPEUTICS, HIV-positive persons, NATURAL immunity
Abstract

The identification of immune correlates of HIV control is important for the design of immunotherapies that could support cure or antiretroviral therapy ( ART) intensification-related strategies. ART interruptions may facilitate this task through exposure of an ART partially reconstituted immune system to endogenous virus. We investigated the relationship between set-point plasma HIV viral load ( VL) during an ART interruption and innate/adaptive parameters before or after interruption. Dendritic cell ( DC), natural killer ( NK) cell and HIV Gag p55-specific T-cell functional responses were measured in paired cryopreserved peripheral blood mononuclear cells obtained at the beginning (on ART) and at set-point of an open-ended interruption from 31 ART-suppressed chronically HIV-1+ patients. Spearman correlation and linear regression modeling were used. Frequencies of plasmacytoid DC (p DC), and HIV Gag p55-specific CD3+ CD4− perforin+ IFN- γ+ cells at the beginning of interruption associated negatively with set-point plasma VL. Inclusion of both variables with interaction into a model resulted in the best fit (adjusted R2 = 0·6874). Frequencies of p DC or HIV Gag p55-specific CD3+ CD4− CSFElo CD107a+ cells at set-point associated negatively with set-point plasma VL. The dual contribution of p DC and anti- HIV T-cell responses to viral control, supported by our models, suggests that these variables may serve as immune correlates of viral control and could be integrated in cure or ART-intensification strategies. [ABSTRACT FROM AUTHOR]

Published
2015
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119. Randomized, Controlled Trial of Therapy Interruption in Chronic HIV-1 Infection

Author

Papasavvas, Emmanouil, primary, Kostman, Jay R, additional, Mounzer, Karam, additional, Grant, Robert M, additional, Gross, Robert, additional, Gallo, Cele, additional, Azzoni, Livio, additional, Foulkes, Andrea, additional, Thiel, Brian, additional, Pistilli, Maxwell, additional, Mackiewicz, Agnieszka, additional, Shull, Jane, additional, and Montaner, Luis J, additional

Published
2004
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124. Persistent Decreases in Blood Plasmacytoid Dendritic Cell Number and Function Despite Effective Highly Active Antiretroviral Therapy and Increased Blood Myeloid Dendritic Cells in HIV-Infected Individuals

Author

Chehimi, Jihed, primary, Campbell, Donald E., additional, Azzoni, Livio, additional, Bacheller, Darlene, additional, Papasavvas, Emmanouil, additional, Jerandi, Ghassen, additional, Mounzer, Karam, additional, Kostman, Jay, additional, Trinchieri, Giorgio, additional, and Montaner, Luis J., additional

Published
2002
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136. Natural History of Patients with Low-Level HIV Viremia on Antiretroviral Therapy.

Author

Re III., Vincent Lo, Gasink, Leanne, Kostman, Jay R., Leonard, Debra, and Gross, Robert

Subjects
ANTIVIRAL agents, HIV-positive persons, AIDS, RNA, VIROLOGY, THERAPEUTICS
Abstract

Ultrasensitive assays for HIV RNA have identified a significant number of patients with persistent low-level viremia despite antiretroviral therapy. The clinical implications of maintaining antiretroviral therapy during low-level HIV viremia remain unclear. The primary objective of this study was to determine the rate and risk factors for virological increase in subjects with low-level HIV viremia who did not change antiretroviral therapy. Between July 1998 and February 2002, we retrospectively observed 79 HIV-infected adults with low-level HIV viremia (between 50 and 500 copies per milliliter) who had been on a stable antiretroviral regimen for at least 3 months and continued that regimen for at least 3 more months. Virologic increase, defined as HIV RNA levels greater than 1000 copies per milliliter, was observed in 29 of the 79 (37%) subjects. The CD4 cell counts decreased by a median of 1.8 cells/mm3 per month (interquartile range [IQR], –19.6 to 2.3 cells/mm3) in this group but increased by a median of 0.5 cells/mm3 per month (IQR, –6.3 to 5.8 cells/mm3) in the 50 subjects who did not experience virologic increase. A Kaplan-Meier estimate showed that at 3 years of follow-up, approximately 40% of the observed cohort had not experienced virologic increase. There was a higher rate of virologic increase per log increase in HIV viral load at entry into the cohort (adjusted hazards ratio [HR] 3.7; 95% confidence interval [CI], 1.1 to 12.6). Subjects of white race were also more likely to experience virological increase (adjusted HR 2.6; CI, 1.2 to 5.8). Maintenance of antiretroviral therapy despite low-level HIV viremia provided sustained immunological benefit over a 2-year period in approximately two thirds of our cohort. Higher initial HIV RNA levels and white race were predictors for virologic increase. [ABSTRACT FROM AUTHOR]

Published
2004
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138. Invasive Colitis and Hepatitis Due to Previously Uncharacterized Spirochetes in Patients with Advanced Human Immunodeficiency Virus Infection.

Author

Kostman, Jay R., Patel, Minal, Catalano, Edison, Camacho, Jeanette, Hoffpauir, John, and DiNubile, Mark J.

Abstract

We describe three patients with advanced human immunodeficiency virus (HIV) infection, two with colitis and one with cholestatic hepatitis, for whom results of detailed endoscopic and histologic studies were suggestive of invasive spirochetosis. In the two patients with colitis, colonoscopic evaluation revealed either diffuse ulcerations or pustules; in both cases, there was histologic evidence of extensive superficial cell necrosis and infiltration of the mucosa and lamina propria with acute inflammatory cells. Spirochetes in the mucosa and crypts were visualized by Warthin-Starry silver staining. Morphologically similar spirochetes throughout the liver specimen from the patient with cholestatic hepatitis were demonstrated by Warthin-Starry silver staining. Analysis with electron microscopy revealed these organisms to be loosely coiled spirochetes. Despite extensive evaluation, no other pathogens were identified. Invasive spirochetal infection, as defined by the results of Warthin-Starry silver staining of involved tissues, should be considered in the differential diagnosis of patients with HIV infection who have otherwise unexplained colitis or cholestatic hepatitis. [ABSTRACT FROM PUBLISHER]

Published
1995
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139. Invasive Haemophilus influenzae Infections in Older Children and Adults in Seattle.

Author

Kostman, Jay R., Sherry, Betty Lou, Fligner, Corinne L., Egaas, Susan, Sheeran, Paul, Baken, Leslie, Bauwens, J. Eric, Clausen, Carla, Sherer, David M., Plorde, James J., Stull, Terrence L., and Mendelman, Paul M.

Abstract

We recently saw two unusual manifestations of Haemophilus influenzae infection in adults in the Seattle area: fulminant sepsis in an otherwise-healthy man and three episodes of bacteremia in a woman with chronic liver disease. We retrospectively identified 79 bacteremic and 40 non-bacteremic cases of invasive H. influenzae infection developing in patients ⩾9 years of age between 1 January 1980 and 31 December 1990. The most common clinical presentations among patients with bacteremia included pneumonia (52%), septicemia (27%), meningitis (8%), gynecologic infection (5%), and epiglottitis (5%). Underlying illnesses were common in these patients, and overall mortality was 35.5%. Factors associated with mortality included underlying neurological disease, polymicrobial bacteremia, and advanced age. The clinical presentations of the 40 patients without bacteremia included soft-tissue abscesses (45%), lung abscesses (18%), peritonitis (13%), meningitis (8%), gynecologic infection (8%), epididymitis (5%), mastoiditis (3%), and osteomyelitis (3%). Thus H. influenzae disease has a variety of presentations and is associated with significant mortality in older children and adults. Further study is required to determine whether widespread administration of H. influenzae type b conjugate vaccine to infants will alter the development of subsequent disease in later life. [ABSTRACT FROM PUBLISHER]

Published
1993
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140. HIV-1-Specific CD4+T Cell Responses in Chronically HIV-1 Infected Blippers on Antiretroviral Therapy in Relation to Viral Replication Following Treatment Interruption

Author

Papasavvas, Emmanouil, Kostman, Jay R., Thiel, Brian, Pistilli, Maxwell, Mackiewicz, Agnieszka, Foulkes, Andrea, Gross, Robert, Jordan, Kimberly A., Nixon, Douglas F., Grant, Robert, Poulin, Jean-francois, Mccune, Joseph M., Mounzer, Karam, and Montaner, Luis J.

Abstract

The impact of transient viral load blips on anti-HIV-1 immune responses and on HIV-1 rebound following treatment interruption (TI) is not known. Clinical and immunological parameters were measured during 40 weeks of antiretroviral therapy (ART) and following TI in an observational cohort of 16 chronically HIV-1-infected subjects with or without observed viral load blips during ART. During therapy, blips in seven subjects were associated with higher anti-HIV-1 (p24) CD4+T cell lymphoproliferative responses (p= 0.04), without a significant difference in T cell activation or total anti-HIV-1 CD8+T cell interferon-γ (IFN-γ) responses when compared to nine matched non-blippers. Therapy interruption resulted in a significantly higher viral rebound in blippers by 8 week despite retention of higher lymphoproliferative p24 responses (p= 0.01) and a rise in CD3+T cell activation (p= 0.04) and anti-HIV-1 CD8+T cell responses in blippers by week 4 when compared to non-blippers. Past week 4 of interruption, therapy re-initiation criteria were also met by a higher frequency in blippers by week 14 (p< 0.04) with no difference between groups by week 24. These data support that blippers have higher anti-HIV lymphoproliferative responses while on ART but experience equal to higher viral rebound as compared to matched non-blippers upon TI.

Published
2006
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141. Efficacy and Safety of Twice-Daily versus Three-Times Daily Saquinavir Soft Gelatin Capsules as Part of Triple Combination Therapy for HIV-1 Infection

Author

Wheat, L Joseph, Farthing, Charles, Cohen, Calvin, Pierone, Gerald, Lalezari, Jay, Pilson, Robert S, Siemon-Hryczyk, Peggy, Baxter, John, Beer, Victor, Bellos, Nicholas C, Bissett, Jack, Braun, James, Brosgart, Carol, Burman, William, Burnside, Alfred, Cervia, Joe, Cheeseman, Sarah, Cimoch, Paul, Cohen, Calvin, DeJesus, Edwin, Diaz, Leslie, Dieterich, Douglas, Dobkin, Jay, Dretler, Robin, El-Sadr, Waafa, Eng, Robert, Farthing, Charles, Feinberg, Judith, Feleke, Getachew, Fessel, Jeffrey, Fish, Douglas, Galpin, Jeffrey, Gathe, Joseph, Gilson, Ian, Gold, Marla, Goodgame, Jeffrey, Goodrich, James, Greenberg, Richard, Greiger, Paola, Grossman, Howard, Grossman, Ron, Hanna, Barbara, Hathaway, Bruce, Hoffman-Terry, Margaret, Jacobson, Susan, Jemsek, Joseph, Jordan, Wilbert, Kaplan, Mark, Kostman, Jay, Lalezari, Jacob, Landesman, Sheldon, Lindquist, Craig, MacArthur, Rodger, Madhava, Valsa, Marsh, Bryan, Martin, Dean, Mathur-Wagh, Usha, McMeeking, Alexander, Miao, Peter, Mogyoros, Miguel, Murphy, Robert, Mustafa, Mahmoud, Nadler, Jeffrey, Norris, Dorece, Onbirbak, Brian, Parker, Richard H, Pearce, Daniel, Pierone, Gerald, Poblete, Ronald, Poretz, Donald M, Reyelt, M Christine, Rivera-Vazquez, Carlos, Salvato, Patricia, Sands, Michael, Schwartz, Robert, Sension, Michael, Skowron, Gail, Slater, Leonard, Smith, David, Stavola, Joseph, Steinhart, Corklin, Temesgen, Zelalem, Thompson, Melanie, Timpone, Joseph, Valentine, Fred T, Vollmer, Kelly, Wada, Suzanne, Ward, Douglas, Wheat, L Joseph, Yangco, Bienvenido, Carey, Peter, Jablonowski, Helmut, Theisen, Albert, Lazzarin, Adriano, and Ocana, Inma

Abstract

Objective The objective of this study was to determine whether a triple therapy regimen incorporating twice-daily saquinavir is as effective as a three-times daily regimen.Methods This was an open-label, Phase III, multicentre, 48-week study involving 837 HIV-1-infected patients randomised to one of the following: saquinavir soft gel capsule (SGC) 1200 mg three-times daily, plus two nucleoside reverse transcriptase inhibitors (NRTIs) (arm A); saquinavir SGC 1600 mg twice-daily, plus two NRTIs (arm B); saquinavir SGC 1200 mg twice-daily and nelfinavir 1250 mg twice-daily, plus a single NRTI (arm C). The primary outcome measure was the virological response in arm A versus B and in arm A versus C with respect to the percentage of patients whose plasma HIV-1 RNA levels fell below the level of quantification for the Amplicor assay (<400 copies/ml) at weeks 24 and 48.Results At 48 weeks, the percentage of patients with plasma HIV-1 RNA levels <400 copies/ml was 47.1% (arm A), 45.3% (arm B) and 42.7% (arm C) in the intention-to-treat analysis. The treatment difference between arm B–arm A was -1.8% (95% confidence intervals -10.1, 6.5) and for arm C–arm A was -4.5% (95% confidence intervals -12.7, 3.7) in the intention-to-treat analysis. These differences fell within the maximum allowable difference (±12%) for arm B compared with arm A. At week 24, the percentage of patients with HIV-1 RNA levels <400 copies/ml was 59.6% (arm A), 57.6% (arm B) and 51.3% (arm C).Conclusions A twice-daily triple therapy regimen incorporating saquinavir SGC plus two NRTIs was of equivalent efficacy to the three-times daily regimen studied. All regimens were generally well tolerated.

Published
2002
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142. Granulomatous Tophaceous Gout Mimicking Tuberculous Tenosynovitis: Report of Two Cases.

Author

Kostman, Jay R., Rush, Patrick, and Reginato, Antonio J.

Abstract

Granulomatous inflammation in a tissue specimen raises concern about infection with Mycobacterium tuberculosis, atypical mycobacteria, certain fungi, Brucella species, and other infectious agents. Inflammatory disorders, such as sarcoidosis, crystal-associated arthritis, or foreign body reactions also are considered when granulomatous changes are seen on histological examination of a tissue specimen. We describe two cases of granulomatous tenosynovitis due to tophaceous deposits in patients with gout. In one case, tuberculous synovitis was considered the primary diagnosis until the diagnosis of gout was confirmed by examination of a tissue specimen with polarized light. In the second case, gout and tuberculosis were found in the patient's wrist joint. After antituberculous therapy was discontinued, he continued to have wrist synovitis and chronic drainage due to granulomatous tophaceous gout. The findings in this report suggest that gouty tenosynovitis can mimic tuberculous tenosynovitis and that gout should be considered in the differential diagnosis of granulomatous tenosynovitis, especially when acid-fast stains and cultures are negative for mycobacteria. [ABSTRACT FROM PUBLISHER]

Published
1995

143. Comparison of the prevalence, severity, and risk factors for hepatic steatosis in HIV-infected and uninfected people.

Author

Torgersen, Jessie, So-Armah, Kaku, Freiberg, Matthew S., Goetz, Matthew B., Budoff, Matthew J., Lim, Joseph K., Taddei, Tamar, Butt, Adeel A., Rodriguez-Barradas, Maria C., Justice, Amy C., Kostman, Jay R., Lo Re III, Vincent, and Lo Re, Vincent 3rd

Subjects
FATTY degeneration, DISEASE risk factors, HIV infections, HEPATIC fibrosis, DISEASE prevalence, FATTY liver
Abstract

Background: Hepatic steatosis is prevalent in Western countries, but few studies have evaluated whether the frequency and severity of steatosis are greater in the setting of HIV infection. We compared the prevalence and severity of hepatic steatosis between HIV-infected (HIV+) and uninfected persons and identified factors associated with greater steatosis severity within both groups.Methods: We performed a cross-sectional study among participants without cardiovascular disease who participated in a substudy of the Veterans Aging Cohort Study. Hepatic steatosis was defined by noncontrast computed tomography (CT) liver-to-spleen (L/S) attenuation ratio < 1.0. Multivariable linear regression was used to: 1) evaluate the association between HIV infection and severity of hepatic steatosis, as measured by absolute liver attenuation, and 2) identify factors associated with greater severity of steatosis, by HIV status.Results: Among 268 participants (median age, 55 years; 99% male; 79% black; 23% obese; 64% HIV+ [91% on antiretroviral therapy]), the overall prevalence of steatosis was 7.8% and was similar between HIV+ and uninfected individuals (13 [7.6%] versus 8 [8.2%], respectively; p = 0.85). Participants with HIV, the majority of whom received antiretroviral therapy, had a higher mean absolute liver attenuation (mean difference, 5.68 Hounsfield units; p < 0.001), correlating with lesser hepatic steatosis severity, compared to uninfected participants. After adjusting for covariates, only advanced hepatic fibrosis was associated with greater severity of steatosis in HIV+ persons (p = 0.03) and uninfected individuals (p < 0.001).Conclusions: In this sample of participants without cardiovascular disease, the prevalence of hepatic steatosis by noncontrast abdominal CT was not different by HIV status. Increasing severity of steatosis was independently associated with advanced hepatic fibrosis in both groups. [ABSTRACT FROM AUTHOR]

Published
2019
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144. Predictors of CD4 count change over 8 months of follow up in HIV-1-infected patients with a CD4 count >= 300 cells/mu L who were assigned to 7.5 MIU interleukin-2

Author

Fox, Zoe, Antunes, Francisco, Davey, Rick, Gazzard, Brian, Klimas, Nancy, Labriola, Ann, Losso, Marcelo, Neaton, James D., Phillips, Andrew N., Ruxrungtham, Kiat, Staszewski, Schlomo, Weiss, Laurence, Lundgren, Jens D., Abrams, Donald I., Cooper, David A., Darbyshire, Janet H., Duncan, William R., Emery, Sean, Lane, H. Clifford, Lehrman, Sandra, Aguilar, Liliana, Betina Angel, Eleonora, Aquilia, Silvia, Belloso, Waldo, Benetucci, Jorge, Bittar, Victor, Cahn, Pedro, Casiro, Arnaldo, Contarelli, Jorge, Corral, Jorge, Daciuk, Lucia, David, Daniel, Ferrari, Ines, Fridman, Diego, Galache, Viviana, Guaragna, Graciela, Ivalo, Silvina, Laplume, Hector, Lanusse, Isabel, Lasala, Maria B., Lattes, Roberta, Lasovsky, Jaime, Lopardo, Gustavo, Lourtau, Leonardo, Lupo, Sergio, Maranzana, Aldo, Marson, Cristina, Massera, Lucila, Del Lujan Sanchez, Marisa, Somenzini, Carla, Tocci, Mariel, Algar, Sally, Anderson, Jonathan, Baker, David, Blavius, Kathy, Bloch, Mark, Boyle, Michael, Bradford, David, Britton, Phillip, Carrall, Leah, Carr, Andrew, Chuah, John, Curry, Michael, D Arcy-Evans, Clive, Dobson, Pauline, Doong, Nicholas, Egan, Cari, Ferguson, Wendy, Finlayson, Robert, French, Martyn, Frater, Anthony, Gold, Julian, Habel, Philip, Haig, Kay, Holland, Rohan, Hyland, Natalie, Hoy, Jennifer, Hudson, Jeff, James, Robyn, Leung, Jenny, Lowe, Kaye, Macrae, Karen, Mcmurchie, Marilyn, Medland, Nicholas, Miller, Samantha, Murray, Jo, Newman, Rosie, Orth, David, Patching, Julie, Primrose, Ruth, Ree, Hugo, Richardson, Robyn, Rogers, Gary, Roney, Janine, Roth, Norman, Sarangapany, Jeganathan, Shaw, David, Silberberg, Carol, Skett, Jenny, Williams, Leah, Soo, Tuck Meng, Sowden, David, Street, Alan, Vale, Robyn, Villella, Claudio, Walker, Alan, Watson, Ashley, Wendt, Ngaire, Wood, Helen, Youds, David, Aichelburg, Alexander, Rieger, Armin, Vetter, Norbert, Clumeck, Nathan, Wit, Stephane, Kabeya, Kabamba, O Doherty, Elizabeth, Amorim, Cristiane Sales, Basso, Caritas Relva, Lewi, David Salamao, Pereira, Luiz Carlos, Da Silva, Mariliza, Lobato Souza, Tamara Newman, Angel, Jonathan, Bouchard, Pierrette-Rolande, Clark, Fran, Cohen, Jeff, Dambreville, Mimose, Ellis, Michele, Fiset, Stephan, Foster, Andrea, Fraser, Christopher, Gagnon, Susan, Gilmour, Janet, Guenette, Richard, Haldane, Heather, Hawley-Foss, Nanci, Hyndman, Susan, Johnston, Lynn, Jubinville, Nathalie, Juneau, Francoise, Kelleher, Lynn, Lapointe, Lyne, Latendre-Paquette, Judy, Lindemulder, Adeline, Mashinter, Laura, Lefebvre, Eric, Mcfarland, Nancy, Morisseau, Chantal, O Neill, Robert, Piche, Alain, Ralph, Edward, Rouleau, Danielle, Routy, Jean-Pierre, Sandre, Roger, Schmidt, Shelley, Shafran, Stephen, Smaill, Fiona, Stromberg, Dale, Trepanier, Jean-Marc, Trottier, Sylvie, Veal, Susanne, Walmsley, Sharon, Weiss, Karl, Williams, Kurt, Young, Mavis, Zaleschuk, Barbara, Zarowny, Don, Baadegaard, Bente, Black, Finn, Boedker, Kirsten, Gerstoft, Jan, Jensen, Lene, Mathiesen, Lars, Nielsen, Henrik, Pedersen, Court, Petersen, Dorthe, Aboulker, Jean-Pierre, Baakili, Adyb, Bengrait, Nafissa, Bensalem, Maryse, Berthe, Huguette, Bloche, Martin, Bazin, Claude, Boue, Francois, Bouvet, Elisabeth, Brancon, Christiane, Capitant, Catherine, Ceppi, Carole, Cheneau, Christine, Coutellier, Anne, Chennebault, Jean Marie, Coquet, Fabienne, Truchis, Pierre, Delavalle, Anne-Marie, Frixon-Marin, Veronique, Gastaut, Jean-Albert, Delfraissy, Francois, Eliaszeicz, Muriel, Gallais, Herve, Gataut, Jean-Albert, Gilquin, Jacques, Gonzalez-Canali, Gustavo, Gaudebout, Chrisiane, Goujard, Cecile, Hoen, Bruno, Honore, Patricia, Jarousse, Bernard, Lang, Jean-Marie, Lefebvre, Benedict, Levy, Yves, Loison, Jocelyne, Maignan, Aline, Meynard, Jean-Luc, Michon, Christophe, Mole, Martin, Marsal, Laurence, Matheron, Sophie, Mortier, Emmanuel, Oksenhendler, Eric, Poirier, Sandrine, Picard-Dahan, Catherine, Ravaux, Isabelle, Raffi, Francois, Raguin, Gilles, Reynes, Jacque, Rozenbaum, Willy, Salmon, Dominique, Simon, Anne, Spiridon, Gabriella, Viard, Jean-Paul, Vidal, Michele, Zucman, David, Bergmann, Frank, Brockmeyer, Norbert, Faetkenheuer, Gerd, Fenske, Stefan, Gey, Daniela, Goebel, Frank-Detlef, Goetsch, Martina, Hartmann, Martin, Klinker, Hartwig, Kremer, Gisela, Mantzsch, Kathleen, Mauss, Stefan, Rockstroh, Juergen, Rotty, Jessica, Rund, Ellen, Schneider, Katrin, Schuermann, Dirk, Staszweski, Schlomo, Tilmann, Klaus, Vogel, Martin, Bentwich, Zvi, Drora, Goldstain, Kedem, Eynat, Lang, Ruth, Levi, Itzic, Maayan, Shlomo, Magen, Eli, Mamorsky, Merav, Pilpul, Anat, Pollack, Shimon, Sthoeger, Zev, Vered, Hadas, Yust, Israel, Lyons, Fiona, Mulcahy, Fiona, Rochford, Annette, Auiti, Fernando, Angarano, Gioacchino, Bertelli, Davide, Bini, Teresa, Bruno, Raffaele, Cadeo, Gian Pietro, Carosi, Giampietro, D Arminio Monforte, Antonella, Del Giacco, Sergio, Di Pietro, Massimo, Esposito, Roberto, Filice, Gaetano, Gavazzeni, Gabriella, Guaraldi, Giovanni, Indiveri, Francesco, Lazzarin, Adriano, Mazzotta, Francesco, Minolli, Lorenzo, Montroni, Maria, Moroni, Mauro, Nozza, Silvia, Pastor, Guiseppe, Poli, Guido, Raise, Enzo, Romagnani, Sergio, Rusconi, Vega, Sacchi, Paolo, Suter, Fredy, Tambussi, Giuseppe, Tirelli, Umberto, Fraser, Helen, Iwamoto, Aikichi, Kikuchi, Yoshida, Mori, Masahiko, Nakamura, Tetsuya, Odawara, Takashi, Oka, Shinichi, Shirasaka, Takuma, Takano, Misao, To, Junichiro, Ueta, Chisato, El Filali, Kamal, Erradey, Ikbale, Himmich, Hakima, Blok, W., Borleffs, J., Bravenboer, B., Bronveld, W., Claessen, F., Duurvoort, Maurice, Ferwerda, J., Frissen, P., Hulshoff, Nicolette, Juttman, Job, Kauffmann, R., Koopmans, P., Kroon, F., Lowe, Selwyn, Leemhuis, M., Meenhorst, P., Boer, Lieselotte Posthuma, Reiss, Peter, Reinders-Folmer, S., Richter, C., Santegoets, Rick, Schoemaker, Marijke, Schrey, G., Sprenger, Herman, Ten Veen, Jacob, Tessalaar, Judith, Ende, M., Vall, H., Eeden, Arne, Leeuwen, Remko, Vermeulen, Joost, Ten Kate, Reinier W., Boxtel, Renee, Eden, Arne, Ven, Bernadette, Meulen, Piet, Ten Napei, C., Vriesendrop, R., Bruun, Johann, Bakowska, Elzbieta, Beniowski, Marek, Boron-Kaczmarska, Anna, Gasiorowski, Jacek, Gxadysz, Andrzej, Horban, Andrzej, Knysz, Brygida, Mularska, Elzbieta, Pynka, Magdelena, Szymczak, Aleksandra, Aldir, Isabel, Doroana, Manuela, Duque, Luis, Mansinho, Kamal, Pinto, Inez, Valadas, Emilia, Vera, Jose, Foo, Estelle, Panchalingham, Anushia, Lim, Poh Lian, Paton, Nick, Peperstraete, Bernard, Quek, Angela, Alcazar-Caballero, Rosario, Arrizabalaga, Julio, Bouza, Emilio, Cepeda, Concepcion, Barron, Xabier, Cervero Jimenez, Miguel, Clotet, Bonaventura, Cortes, Luis, Domingo, Pere, Fernandez, Pompeyo, Fernandez-Cruz, Eduardo, Fuster, Montserrat, Gatell, Jose, Gijon, Paloma, Gil, Ignacio, Gonzales-Lahoz, Juan, Gonzalez, Alicia, Hernandez, Manuel, Iribarren, Jose, Jimenez, Miguel, Knobel, Hernando, Leon, Agathe, Carlos Lopez, Juan, Lozano, Angeles, Lopez, Paco, Moreno, Jose, Munoz, Rosa, Padilla, Belen, Parras, Angeles, Pastor, Antoni, Pedreira, Jose, Pristo, Julio, Pena, Jose, Roca, Victor, Rubio, Rafael, Sanchez Rivera, Jose, Sanz, Jesus, Tamargo, Lara, Torres, Rafael, Pehrson, Pehr O., Sandstrom, Eric, Bernasconi, Enos, Gurtner, Vanina, Magenta, Lorenzo, Ampunpong, Uangarun, Bowonwatnuwong, Chureeratana, Chanchai, Patimoaporn, Chetchotisakd, Ploenchan, Chuenyam, Thesinee, Duncombe, Chris, Horsakulthai, Mannassinee, Kantipong, Pacharee, Liddy, John, Phanuphak, Praphan, Pongsurachet, Vithaya, Seekaew, Samroeng, Sonjai, Areerat, Subsri, Nuramon, Suwanagool, Surapol, Techasathit, Wichai, Wankoon, Jaturaporn, Adebiyi, Aderonke, Aldam, Diana, Alexander, Ian, Angus, Brian, Barber, Tristan, Bonnington, Sue, Care, Chris, Carroll, Anne, Cornforth, David, Donaldson, Oscar, Druiff, Laurance, Easterbrook, Philippa, Edwards, Beverley, Ellis, Chris, Fisher, Martin, Fox, Ray, Harrison, Allan, Herman, Sandra, Heald, Lisa, Higgs, Christopher, Jendrulek, Isabelle, Johnson, Margaret, Judges, Lucy, Karim, Fatimah, Kinghorn, George, Laurenti, Julie, Lee, Christine, Leen, Clifford, Legg, Ken, Maw, Raymond, Macconachie, Alisdair, Mckernan, Sinead, Mclean, Lorna, Mcmillan, Andrew, Mguni, Sifiso, Morris, Sheila, Mulchay, Fiona, Mullan, Dee, Mullaney, Scott, Murphy, Maurice, Nunn, Andrew, Ong, Edmund, Owen, Maxine, Palfreeman, Adrian, Perry, Nicky, Peters, 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Lynn, Child, Carroll, Cohn, David, Cooper, Pam, El-Sadr, Wafaa, Farrough, Martha, Fisher, Evelyn, Fuentes, Luis, Gordin, Fred, Graeber, Carol, Kelly, Mary Ellen, Kostman, Jay, Lattanzi, Kelly, Macarthur, Rodger, Makohon, Linda, Markowitz, Norman P., Martinez, Norma, Mastro-Polak, Diane, Mitchell, Vinnie, Mushatt, David, Patterson, Kathryn, Perez, George, Rosmarin, Corey, Rouff, Jack R., Saldanha, Jennifer, Sampson, James, Sawyer, Robert, Standridge, Barbara, Sweeton, Bentley, Tedaldi, Ellen, Thompson, Melanie, Valencia, Patricia, Verlinghieri, Gwen, Walker, Janice, Watson, Vicky, Williams, Bruce, Armstrong, Adam, Banks, Susan, Blazes, David, Barile, Anthony, Coelho, Linda, Dennis, Marilyn, Flaks, Hannah, Gilcrest, Joyce, Gittens, Kathleen, Hopper, Shelia, Humphries, M. J., Spooner, Katherine, Tamminga, Cindy L., Vita, Jean, Wegner, Scott A., Wortmann, Glenn, Bisby, Nicole, Blake, William, Brown, Sheldon, Chilliade, Phillippe, Cole, Teresa, Elliot, Katherine, Geisler, Christiane, Goetz, Matthew, Gomez-Perez, Elizabeth, Helman, Jami, Nahass, Ronald, Leflore, Dirk, Marston, Barbara, Obregon, Maria, Petrolati, Jennifer, Pitrak, David L., Roland, Robert, Rosa, Carol, Rossman, Barbara, Schlueter Wirtz, Susan, Schuck, Suzanne, Scretchings, Tiffany, Simon, Gary, Smith, Mack, Summers, Kimberley, Werhane, Mary Jo, Arduino, Roberto, Bell, Brian, Breaux, Katherine, Cuervo, Hilda, Hale, Carl, Lewis, Stanley, Mall, Mark, Mora, Fransisco, Diez, Martine M., Okhuysen, Pablo, Rodriguez-Barradas, Maria, Schrader, Shannon R., Healy, Lynn, Kaszubski, Chris, Kolber, Michael, Tanner, Tom, Armstrong, Joann, Dahlke, Jennifer, Johnson, Leonard, Kaminski, Patricia, Rhame, Frank, Shoden, Cheryl, Temesgen, Zelalem, Urbanich, Marcy, Valenti, Sharon, Zervos, Marcus, Barrick, Bill, Chaitt, Doreen, Hahn, Barbara, Lane, Cliff, Martell, Dennis, Mcnay, Laura, Metcalf, Julia, Powers, April, Tavel, Jorge A., Loveless, Karen, Peterson, Sue, Sweek, Suzanne, Albrecht, Helmut, Antoine, Nicole, Pell, Paula, Gatell, Jose Maria, Hoy, Jenny, Lifson, Alan, Pederson, Court, Borup, Liselotte, Dragsted, Ulrik Bak, Greve, Anne Fau, Jensen, Karoline, Jens Lundgren, Mollerup, David, Pearson, Mary, Phillips, Andrew, Aboulhab, Jamila, Babiker, Abdel, Cordwell, Brooke, Darbyshire, Janet, Hack, Lisa, Hooker, Malcolm, Moraes, Yolanda, Newberry, Douglas, Nuwagaba-Biribonwoha, Harriet, Hooff, Fionna, Denning, Eileen, Holland Klemme, Leslie, Carey, Cate, Chan, Fonnie, Cooper, David, Courtney-Rodgers, David, Drummond, Fraser, Jacoby, Simone, Law, Matthew, Stewart, Morgan, Pett, Sarah, Alloo, Zarina, Bebchuk, Judy, Bollenbeck, Patty, Duchene, Alain G., Fosdick, Lisa, Harrison, Merrie, Krum, Eric, Larson, Gregg, Meger, Sue, Neaton, James, Nelson, Ray, Quan, Siu-Fun L., Schultz, Terri, Telke, Susan, Thackeray, Lisa, Thompson, Greg, Wentworth, Deborah, Wyman, Nicole, Duncan, William, Ferguson, Elaine, Fox, Lawrence, Gettinger, Nikki, Herrera, Janet, Luzar, Mary Anne, Maeshiro, Mieko, Martinez, Ana, Oseekey, Karen, Baigent, Greg, Capra, William, Duliege, Anne-Marie, Fitzgerald, Linda, Kwakkelstein, Marthin, Maral, Jean, O Hara, Mary, Sahner, David, Weber, Claire, Adam-Perchec, Christine, Barron, Nigel, Bell, Mary Louise, Dolan, Sandra, Eckstrand, Julie, Hicks, Steven, Mcauley, George, Beck, Sharon, Brown, Shawn, and Rupert, Adam

145. Additional file 1 of Prevalence and risk factors for patient-reported joint pain among patients with HIV/Hepatitis C coinfection, Hepatitis C monoinfection, and HIV monoinfection

Author

Ogdie, Alexis, Wyki Gina Pang, Forde, Kimberly A, Bhangle D Samir, Mulugeta, Lakeisha, Kyong-Mi Chang, Kaplan, David E, Valerianna K Amorosa, Kostman, Jay R, Reddy, Rajender K, Schumacher, Ralph H, and Re, Vincent Lo

Subjects
viruses, virus diseases, digestive system diseases, 3. Good health
Abstract

Laboratory results of human immunodeficiency virus (HIV)/chronic hepatitis C virus (HCV)-coinfected, chronic HCV-monoinfected, and HIV-monoinfected participants.

146. Additional file 1: of Comparison of the prevalence, severity, and risk factors for hepatic steatosis in HIV-infected and uninfected people

Author

Torgersen, Jessie, Kaku So-Armah, Freiberg, Matthew, Goetz, Matthew, Budoff, Matthew, Lim, Joseph, Taddei, Tamar, Adeel Butt, Rodriguez-Barradas, Maria, Justice, Amy, Kostman, Jay, and Re, Vincent Lo

Subjects
3. Good health
Abstract

Supplemental Analyses. Multivariable linear regression models of mean difference in absolute liver attenuation adjusting for variables of interest, in addition to visceral adipose tissue (Table S1) or subcutaneous adipose tissue (Table S3), or stratified by obesity and HIV status (Table S3). (DOCX 21 kb)

147. Additional file 1 of Prevalence and risk factors for patient-reported joint pain among patients with HIV/Hepatitis C coinfection, Hepatitis C monoinfection, and HIV monoinfection

Author

Ogdie, Alexis, Wyki Gina Pang, Forde, Kimberly A, Bhangle D Samir, Mulugeta, Lakeisha, Kyong-Mi Chang, Kaplan, David E, Valerianna K Amorosa, Kostman, Jay R, Reddy, Rajender K, Schumacher, Ralph H, and Re, Vincent Lo

Subjects
viruses, virus diseases, digestive system diseases, 3. Good health
Abstract

Laboratory results of human immunodeficiency virus (HIV)/chronic hepatitis C virus (HCV)-coinfected, chronic HCV-monoinfected, and HIV-monoinfected participants.

148. CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells

Author

Abdel-Mohsen, Mohamed, Kuri-Cervantes, Leticia, Grau-Exposito, Judith, Spivak, Adam M., Nell, Racheal A., Tomescu, Costin, Vadrevu, Surya Kumari, Giron, Leila B., Serra-Peinado, Carla, Genescà, Meritxell, Castellví, Josep, Wu, Guoxin, Del Rio Estrada, Perla M., González-Navarro, Mauricio, Lynn, Kenneth, King, Colin T., Vemula, Sai, Cox, Kara, Wan, Yanmin, Li, Qingsheng, Mounzer, Karam, Kostman, Jay, Frank, Ian, Paiardini, Mirko, Hazuda, Daria, Reyes-Terán, Gustavo, Richman, Douglas, Howell, Bonnie, Tebas, Pablo, Martinez-Picado, Javier, Planelles, Vicente, Buzon, Maria J., Betts, Michael R., and Montaner, Luis J.

Abstract

CD32 is associated with highly activated T cells harboring HIV RNA transcripts and does not enrich for HIV DNA in resting T cells.

Published
2018
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149. Predictors of Severe Liver Fibrosis in HIV-Infected Patients with Chronic Hepatitis C.

Author

Re III, Vincent Lo and Kostman, Jay R.

Subjects
*HIV-positive persons, *HEPATITIS C, *DISEASE risk factors, *LIVER diseases, *PROGNOSIS, *VIRAL hepatitis
Abstract

The article focuses on identifying potential predictors of severe hepatic fibrosis in patients coinfected with both HIV and hepatitis C virus (HCV). The determination of risk factors for severe fibrosis, such as those in this study, can help direct HCV therapy to those at highest risk for progressive liver disease. However, recent data from HCV-monoinfected patients have suggested that additional, potentially modifiable factors may play a relevant role in fibrosis progression. The association between these potential risk factors and severe hepatic fibrosis should have been evaluated, because they may have important prognostic and therapeutic implications in the treatment of HIV-HCV-coinfected patients.

Published
2004

150. Inoculation Herpes Simplex Virus Infections in Patients with AIDS: Unusual Appearance and Location of Lesions.

Author

Weaver, Gayle and Kostman, Jay R.

Abstract

Two patients with AIDS developed protracted infection due to autoinoculation of herpes simplex virus in the great toe and the external ear, respectively, both unusual areas for inoculation. The appearances of the lesions were also unusual; severe hyperkeratosis was noted in both cases and a mass lesion in the external ear in one case. Both patients' conditions responded to acyclovir, although one patient required amputation of a digit due to intractable pain. In each case, the diagnosis was delayed despite the presence of mucocutaneous lesions, resulting in inappropriate treatment and prolonged discomfort. Inoculation disease due to herpes simplex virus should besuspected in patients with AIDS who have unusual skin lesions, particularly if oral and/or perianal lesions are also present. [ABSTRACT FROM PUBLISHER]

Published
1996
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