122 results on '"Koh, Mark Jean‐Aan"'
Search Results
102. Shwachman‐Diamond Syndrome Presenting as Neonatal Ichthyosis.
- Author
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Jacinto‐Calimag, Fatima, Wee, Lynette Wei Yi, Wen, Mildrid Yeo Li, Wei, Christopher Ho Wen, and Koh, Mark Jean‐Aan
- Subjects
- *
SKELETAL abnormalities , *BONE marrow , *CYTOPENIA , *GENETICS , *SYMPTOMS - Abstract
ABSTRACT Shwachman‐Diamond syndrome (SDS) is a rare inherited bone marrow failure syndrome characterized by the triad of exocrine pancreatic dysfunction, cytopenia, and skeletal abnormalities. We report a 5‐month‐old boy with SDS who presented with generalized ichthyosis in the neonatal period that evolved into more eczematous skin eruptions, accompanied by severe failure to thrive. This report highlights the importance of including SDS as a differential diagnosis in patients who present with early ichthyosis, failure‐to‐thrive, gastrointestinal symptoms and cytopenia. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
103. Davener's dermatosis.
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Zi Xean Khoo, Jin Ho Chong, Mark Jean Aan Koh, Khoo, Zi Xean, Chong, Jin Ho, and Koh, Mark Jean Aan
- Subjects
CHILDREN'S hospitals ,GLYCOLIC acid ,CHEMICAL peel - Published
- 2019
- Full Text
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104. Davener’s dermatosis
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Khoo, Zi Xean, Chong, Jin Ho, and Koh, Mark Jean Aan
- Published
- 2019
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105. Vesicles on the Breast Post-mastectomy: A Quiz.
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Chee, Jade Nicolette and Koh, Mark Jean-Aan
- Subjects
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BREAST cancer , *MASTECTOMY - Abstract
A quiz related to the case of a 43 year old Chinese woman diagnosed with carcinoma of her left breast in September 2005 and underwent a left skin-sparing mastectomy.
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- 2015
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106. A 10-Year Review of Cutaneous Nontuberculous Mycobacterium in Asian Children.
- Author
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Shanna Shan-Yi Ng, Yong-Kwang Tay, and Koh, Mark Jean-Aan
- Subjects
MYCOBACTERIUM ,ASIAN children ,ACUTE myeloid leukemia - Abstract
An abstract of the article "A 10-Year Review of Cutaneous Nontuberculous Mycobacterium in Asian Children," by Shanna Shan-Yi Ng and colleagues is presented.
- Published
- 2014
107. Cutaneous pseudolymphoma occurring after traumatic implantation of a foreign red pigment.
- Author
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Koh, W L, Tay, Y K, Koh, M J, Sim, C S, Koh, Wei Liang, Tay, Yong Kwang, Koh, Mark Jean Aan, and Sim, Chee Seng
- Abstract
Cutaneous pseudolymphoma is an uncommon, benign lymphoproliferative disorder of the skin. Although this condition is most commonly idiopathic, its occurrence has been associated with cosmetic tattoos. We report a unique case of cutaneous pseudolymphoma that occured after accidental, traumatic inoculation of a red pigment in a healthy 33-year-old woman. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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108. Epidermolytic ichthyosis in a child and systematized epidermolytic nevi in the mosaic parent associated with a KRT1 variant.
- Author
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Chia, Shi Yun, Tan, Ene-Choo, Wei, Heming, Zhao, Yi, and Koh, Mark Jean Aan
- Subjects
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ICHTHYOSIS , *NEVUS , *PHENOTYPES , *HISTOPATHOLOGY , *KERATIN - Abstract
Epidermolytic ichthyosis and epidermolytic nevi share the same histopathological features of epidermolytic hyperkeratosis, characterized by distinctive vacuolar degeneration and hypergranulosis of the superficial epidermis. Both are caused by pathogenic variants in either of two keratin genes KRT1 or KRT10 , with epidermolytic ichthyosis presenting as a generalized phenotype and epidermolytic nevi presenting as a mosaic phenotype. We report a boy who presented as epidermolytic ichthyosis, with diffuse erythema, superficial erosions and flaccid blisters at birth progressing to generalized ichthyosis. He was found to have inherited a novel KRT1 variant from his mother who presented with extensive epidermolytic nevi or mosaic form of epidermolytic ichthyosis, with extensive, linear and Blaschkoid verrucous, hyperkeratotic plaques over the trunk and limbs. This case highlights the importance of recognising post-zygotic mosaicism which might be transmitted to a child, and the different presentations for germline and mosaic carriers. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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109. Updated consensus guidelines for management of moderate-to-severe atopic dermatitis in Singapore: Integrating biologics, Janus kinase inhibitors and conventional therapies.
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Yew YW, Alagappan U, Aw D, Chandran NS, Choo KJ, Chu R, Koh HY, Koh MJA, Lee SX, Neoh CY, Tan SL, Tang M, Tay YK, Francis-Graham S, Lim A, and Lee HY
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- Humans, Singapore, Antibodies, Monoclonal, Humanized therapeutic use, Severity of Illness Index, Bridged Bicyclo Compounds, Heterocyclic therapeutic use, Dermatologic Agents therapeutic use, Practice Guidelines as Topic, Pyrimidines therapeutic use, Boron Compounds, Dermatitis, Atopic drug therapy, Janus Kinase Inhibitors therapeutic use, Biological Products therapeutic use, Delphi Technique, Consensus
- Abstract
Introduction: Since 2016, several therapies have been approved for treating atopic dermatitis (AD) in Singapore, including biologics, oral Janus kinase (JAK) inhibitors and topical crisaborole. This study supplements the 2016 Singapore treatment guidelines for AD, focusing on newer therapies for moderate-to-severe disease, while revisiting older treatment regimens to accommodate changes in knowledge and practice., Method: A modified Delphi panel was held, led by 2 co-chairs. The voting expert panel consisted of 12 dermatologists experienced in managing AD in Singapore. Delphi survey rounds were conducted between 24 July and 27 October 2023. Panellists indicated their agreement with drafted statements using a 5-point Likert scale. Consensus was defined as ≥80% agreement. An expert meeting was held to facilitate the consensus process between rounds 1 and 2 of voting., Results: All expert panellists participated in both survey rounds, with a 100% response rate. Thirty-nine statements, classified into general principles, conventional treatments, biologics and JAK inhibitors, were proposed. Of these, 27 statements reached consensus at the end of round 1. After the expert meeting, 17 statements were included in round 2, of which 16 statements reached consensus. One statement did not reach consensus. Key updates are the inclusion of dupilumab and JAK inhibitors as potential first-line treatments for moderate-to-severe AD, in certain populations., Conclusion: This modified Delphi study generated consensus among Singapore dermatology experts, to update treatment guidelines in moderate-to-severe atopic dermatitis. The consensus statements developed are intended to supplement the 2016 Singapore treatment guidelines for AD. Further revisions may be required when new evidence and/or treatments become available.
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- 2024
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110. Cutaneous cytomegalovirus mimicking mpox in an immunocompromised infant.
- Author
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Chong JH, Isa MSB, Koh MJA, and Lee AC
- Abstract
Competing Interests: Competing interests: None declared.
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- 2024
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111. Phototherapy for the treatment of atopic dermatitis in Singaporean children and adolescents.
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Chia SY, Chee EEC, Wee LWY, and Koh MJA
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- Humans, Child, Female, Adolescent, Male, Singapore, Child, Preschool, Retrospective Studies, Phototherapy, Ultraviolet Therapy adverse effects, Dermatitis, Atopic therapy, Dermatitis, Atopic radiotherapy
- Abstract
Background/purpose: Phototherapy has emerged as a safe yet effective form of treatment of atopic dermatitis (AD). Few studies have been done to evaluate the efficacy of phototherapy in Asian children. The aim of this study was to review the phototherapy experience in a cohort of Asian pediatric patients with AD at a tertiary dermatologic center in Singapore., Methods: A retrospective study of patients 18 years and below with AD who had undergone phototherapy at KK Women's and Children's Hospital, Singapore, over a 4-year period was performed., Results: Sixty-two patients were identified, between ages 4 and 16 years (mean age 11 years) at the time of commencement of phototherapy. Thirty-five (60%) patients were males and 23 (40%) were females. Most patients had moderate to severe disease, with 60.3% of the patients with an initial body surface area (BSA) involvement of 31%-60% and 13.8% of the patients with an initial BSA involvement of 61%-90%. For patients who had undergone narrowband ultraviolet B (NBUVB) and combined ultraviolet A (UVA) and NBUVB phototherapy, the mean reduction of the Eczema Area and Severity Index (EASI) scores were 11.4 and 7.9, respectively. Common side effects experienced include xerosis, pruritus, erythema, and pain. Other reasons for cessation of therapy in the NBUVB group included time commitment difficulty (9.3%), hyperactivity (2.3%), and claustrophobia (2.3%). Two patients that had photochemotherapy (psoralen + UVA) [PUVA] suffered from post-UVA burns requiring cessation of treatment. More than half of the patients (56.9%) treated with phototherapy experienced treatment success with improvement in Investigator Global Assessment and EASI scores. 86.2% of the patients had good compliance to the treatment regime, 12% had poor-compliance, and 3.4% were lost to follow-up., Conclusion: Phototherapy is a useful treatment adjunct for moderate to severe AD in Asian children., (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2024
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112. An unusual case of itchy subcutaneous nodules secondary to aluminium allergy from vaccination.
- Author
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Teo NAH, Koh MJ, and Wee LWY
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- Humans, Aluminum adverse effects, Pruritus etiology, Vaccination, Skin Neoplasms, Hypersensitivity
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- 2024
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113. A Sensorised Glove to Detect Scratching for Patients with Atopic Dermatitis.
- Author
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Au CY, Leow SY, Yi C, Ang D, Yeo JC, Koh MJA, and Bhagat AAS
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- Child, Humans, Pilot Projects, Pruritus diagnosis, Pruritus etiology, Upper Extremity, Dermatitis, Atopic diagnosis
- Abstract
In this work, a lightweight compliant glove that detects scratching using data from microtubular stretchable sensors on each finger and an inertial measurement unit (IMU) on the palm through a machine learning model is presented: the SensorIsed Glove for Monitoring Atopic Dermatitis (SIGMA). SIGMA provides the user and clinicians with a quantifiable way of assaying scratch as a proxy to itch. With the quantitative information detailing scratching frequency and duration, the clinicians would be able to better classify the severity of itch and scratching caused by atopic dermatitis (AD) more objectively to optimise treatment for the patients, as opposed to the current subjective methods of assessments that are currently in use in hospitals and research settings. The validation data demonstrated an accuracy of 83% of the scratch prediction algorithm, while a separate 30 min validation trial had an accuracy of 99% in a controlled environment. In a pilot study with children ( n = 6), SIGMA accurately detected 94.4% of scratching when the glove was donned. We believe that this simple device will empower dermatologists to more effectively measure and quantify itching and scratching in AD, and guide personalised treatment decisions.
- Published
- 2023
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114. Approach to clinically significant vascular anomalies in children.
- Author
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Tanugroho RR, Wee LWY, Koh MJA, and Chong JH
- Subjects
- Infant, Newborn, Child, Humans, Syndrome, Vascular Malformations diagnosis, Vascular Malformations therapy, Vascular Malformations pathology, Vascular Diseases
- Abstract
Vascular anomalies consist of tumours or malformations made up of abnormal growth or collections of blood vessels that can result in functional or cosmetic problems. While many vascular anomalies are present at birth, some do not appear until later in life, making diagnosis more challenging. Although many vascular anomalies are benign, some are associated with serious complications and may involve multiple organ systems. This article highlights the important features of clinically significant vascular anomalies to help physicians promptly identify and refer these cases to a specialised multidisciplinary team for evaluation and management. The discussion includes the various presenting complaints of vascular anomalies in children, namely, rapidly growing birthmarks, painful lesions, seizures/neurological manifestations, bleeding diathesis, cardiac/airway abnormalities and part of an overgrowth syndrome., Competing Interests: None
- Published
- 2023
- Full Text
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115. Oral propranolol for the treatment of infantile haemangiomas in Singapore.
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Tan JMC, Lim HW, and Koh MJ
- Subjects
- Adrenergic beta-Antagonists therapeutic use, Child, Female, Humans, Infant, Infant, Newborn, Infant, Premature, Propranolol therapeutic use, Retrospective Studies, Singapore, Treatment Outcome, Hemangioma drug therapy, Skin Neoplasms
- Abstract
Introduction: Infantile haemangiomas (IH) are the most common vascular tumours in childhood. Over the past decade, treatment of IH has been revolutionised by the discovery of the effectiveness of beta-blockers in its treatment. We review our hospital's experience with oral propranolol in the treatment of IH in an Asian population., Methods: We performed a retrospective review of the medical records and clinical photos of paediatric patients with IH treated with propranolol in a tertiary paediatric hospital in Singapore from January 2010 to February 2015., Results: A total of 88 patients with IH treated with propranolol were identified over a five-year period, with 79 patients included in the final analysis. There was a predominance of female patients (75.9%) and preterm infants (41.8%) in our study population. The head and neck (65.8%), especially the orbital or preorbital region (45.6%), were the most common lesion sites in our cohort of patients. Mean age of onset was 2.3 ± 4.5 weeks of age, and mean age of starting propranolol treatment was 7.7 ± 10.5 weeks of age. 44.3% of patients experienced > 75% improvement, while 29.1% experienced improvement of 50%-75%. Response to treatment was influenced by the age of starting treatment., Conclusion: Our study provides further evidence of the efficacy and safety of propranolol in the treatment of IH in an Asian population. Early treatment is recommended for optimal results., (Copyright: © Singapore Medical Association.)
- Published
- 2021
- Full Text
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116. Practical Recommendations for the Topical Treatment of Atopic Dermatitis in South and East Asia.
- Author
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Luk D, Hon KLE, Dizon MVC, Leong KF, Tay YK, Koh MJ, Chandran NS, Wananukul S, Chatproedprai S, and Luger T
- Abstract
Introduction: There is some evidence to suggest that the prevalence of atopic dermatitis (AD) in Asia is rising. We have therefore developed an algorithm for the topical treatment of AD throughout South and East Asia for use by primary care physicians, pediatricians and dermatologists., Methods: Nine AD experts from South and East Asia and one from Europe developed the algorithm based upon treatment guidelines, relevant literature and local treatment practices. The algorithm outlines current best practice for the use of emollients, topical corticosteroids (TCS) and topical calcineurin inhibitors (TCI), with the intention of simplifying the treatment regimen of mild-to-moderate AD in South and East Asia., Results: Patients with AD should bathe and cleanse affected skin to remove crusts and scales daily. Emollients should also be applied daily as a maintenance treatment. When selecting appropriate topical anti-inflammatory treatment for AD flares, several factors should be taken into consideration, including the patient's age, attitude to treatment options and site of AD lesions. Given the concerns regarding the risk of skin atrophy with use of TCS, a TCI should be used to treat AD lesions in sensitive skin areas: pimecrolimus is recommended for mild-to-moderate AD in these locations, while tacrolimus should be considered for moderate and severe cases. Either pimecrolimus or tacrolimus is recommended for flares in other, non-sensitive body locations. A proactive or intermittent maintenance treatment strategy involving regular emollient use and twice-weekly application of a TCI to previously affected areas is encouraged to reduce the risk of flares., Conclusions: The algorithm proposed here is intended to simplify the topical treatment of mild-to-moderate AD in daily practice in South and East Asian countries.
- Published
- 2021
- Full Text
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117. Comparing the Potential for Irritation of a Ceramide-Based Moisturizer with a Urea-Based Moisturizer for Pediatric Atopic Dermatitis.
- Author
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Ho VPY, Ma E, Liew HM, Ng MSY, and Koh MJA
- Abstract
Introduction: Moisturizers are one of the mainstays of the topical treatment of atopic dermatitis (AD). One of the adverse effects of moisturizers is skin irritation, especially on excoriated AD skin. We compared the potential for irritation of two commercially available moisturizer products for the treatment of AD: a ceramide-based moisturizer (Ceradan
® Cream; Hyphens Pharma Pte Ltd, Singapore) and a urea 5% moisturizer (Aqurea Lite Cream; ICA Pharma Pte Ltd, Singapore)., Methods: We performed a prospective single-blind randomized controlled study recruiting AD patients aged between 8 and 16 years with symmetrical or near symmetrical scratch marks (excoriations) of at least grade 2 to 3 severity score, according to the Eczema Area and Severity Index (EASI), over bilateral antecubital fossae. Subjects were randomized to receive the ceramide-based moisturizer to either the left or right antecubital fossa or urea 5% cream to the other antecubital fossa. Subjects were asked to grade the immediate skin irritation of both creams on a standard visual analogue scale (VAS) and which cream they would prefer to use as a daily moisturizer. Primary outcome was the mean irritant score of each cream, and secondary outcome was the subjects' preference of either cream as their daily moisturizer., Results: A total of 42 participants were enrolled with a mean age of 11 years 5 months. The ceramide-based cream had a significantly lower mean VAS score (mean 0.69, SD = 1.63) for irritation compared with urea 5% cream (1.43, SD = 1.64) (p = 0.035). More participants also preferred the ceramide-based cream over urea 5% cream (62% versus 38%) as their daily moisturizer, but this did not reach statistical significance (p = 0.164)., Conclusions: A ceramide-based moisturizer may be considered as a suitable choice for children to minimize irritation from moisturizer treatment for AD.- Published
- 2020
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118. Factors Influencing Family Burden of Paediatric Patients with Atopic Dermatitis: A Cross-sectional Study.
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Xu X, Galen LS, Bajpai R, Koh MJ, Thng S, Yew YW, Järbrink K, and Car J
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- Child, Cross-Sectional Studies, Humans, Quality of Life, Surveys and Questionnaires, Dermatitis, Atopic diagnosis, Dermatitis, Atopic epidemiology, Eczema
- Published
- 2020
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119. Compound heterozygous mutations with novel missense ABCA12 mutation in harlequin ichthyosis.
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Loo BKG, Batilando MJ, Tan EC, and Koh MJA
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- Acitretin administration & dosage, Female, Genetic Predisposition to Disease, Genotype, Humans, Ichthyosis, Lamellar diagnosis, Ichthyosis, Lamellar drug therapy, Infant, Newborn, Keratolytic Agents therapeutic use, Polymorphism, Single Nucleotide genetics, Prenatal Diagnosis, Sequence Deletion, Treatment Outcome, ATP-Binding Cassette Transporters genetics, Acitretin therapeutic use, Ichthyosis, Lamellar genetics, Mutation genetics, Mutation, Missense genetics
- Abstract
Harlequin ichthyosis (HI) is the most severe form of autosomal recessive congenital ichthyosis, presenting at birth with distinctive facial features and thick, plate-like scales over the entire body. The abnormal skin barrier predisposes the patient to multiple complications, including dehydration and sepsis. Mortality rates of babies with HI have been greatly reduced since the introduction of systemic retinoid therapy. Mutations in ABCA12 have been found to lead to HI. Most of these mutations are truncation or deletion mutations in the conserved region of the protein, leading to severe loss of ABCA12 function. We report a case of HI caused by a compound heterozygous mutation (a known single nucleotide deletion and a novel single nucleotide substitution) in the ABCA12 gene., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
- Published
- 2018
- Full Text
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120. Simply eczema.
- Author
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How CH, Quah JH, and Koh MJ
- Subjects
- Chronic Disease, Dermatitis, Atopic physiopathology, Education, Medical, Continuing, Humans, Inflammation, Primary Health Care methods, Skin pathology, Dermatitis, Atopic diagnosis, Dermatitis, Atopic therapy, Dermatology methods
- Abstract
Atopic eczema is a commonly encountered chronic skin condition in primary care. In this article, we share a holistic, structured approach, which is grounded on the chronic and atopic nature of the condition - planned reviews, patient empowerment, a written action plan for chronic and fare management, and trigger avoidance. Common pitfalls in management are insufficient emphases on scheduled reviews and patient empowerment, as well as neglect in the care of the loss of the epidermal barrier during acute flares.
- Published
- 2013
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121. A review of patients managed at a combined psychodermatology clinic: a Singapore experience.
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Chung WL, Ng SS, Koh MJ, Peh LH, and Liu TT
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- Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Psychophysiologic Disorders complications, Psychophysiologic Disorders epidemiology, Retrospective Studies, Singapore epidemiology, Skin Diseases complications, Skin Diseases epidemiology, Young Adult, Disease Management, Hospitals, Special, Psychophysiologic Disorders therapy, Skin Diseases therapy
- Abstract
Introduction: Recognising and appropriately treating psychosomatic factors in dermatological conditions can have a significant positive impact on the outcomes of patients. Treatment of psychodermatological patients requires a multidisciplinary approach that involves dermatologists, psychiatrists and allied health professionals., Methods: This was a retrospective case series of patients seen in our psychodermatology liaison conferences from November 2009 to July 2011. We reviewed all the case notes and analysed data such as age, gender, dermatologic and psychiatric diagnoses, treatment and outcome., Results: The majority of patients in our cohort were diagnosed with either a psychophysiologic disorder or a primary psychiatric disorder. The most common diagnosis among patients with primary psychiatric disorder was delusions of parasitosis. Other common primary psychiatric disorders seen were trichotillomania and dermatitis artefacta. About a fifth of our patients had psychiatric disorders resulting from their underlying dermatological conditions. A third of our patients were lost to follow-up., Conclusion: Managing patients with psychocutaneous disorders can be challenging, with many patients defaulting treatments. Psychodermatology clinics will benefit both patients and their caregivers. A collaborative approach using a consultation-liaison relationship between two medical departments in a friendly environment would result in more effective, integrated and holistic treatment strategies for such patients. Further studies should be conducted to determine how beneficial such services are to patients. With more experience, we hope to improve this service.
- Published
- 2012
122. Juvenile xanthogranuloma in monozygotic twins.
- Author
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Tan KW, Koh MJ, and Tay YK
- Subjects
- Humans, Infant, Scalp pathology, Twins, Monozygotic, Xanthogranuloma, Juvenile genetics, Xanthogranuloma, Juvenile pathology
- Abstract
Juvenile xanthogranuloma is usually a benign condition mainly seen in infants and children. It frequently presents as asymptomatic discrete papules on the head, trunk, and limbs. Extracutaneous manifestations, most commonly ocular, are rare but may be associated with significant morbidity. The etiology of juvenile xanthogranuloma is uncertain, although the occurrence in monozygotic twins may suggest genetic predisposition., (© 2010 Wiley Periodicals, Inc.)
- Published
- 2010
- Full Text
- View/download PDF
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