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3,032 results on '"Kobayashi, Satoshi"'

101. Reaction Automata

Author

Okubo, Fumiya, Kobayashi, Satoshi, and Yokomori, Takashi

Subjects
Computer Science - Formal Languages and Automata Theory, 68Q45 (Primary) 68Q05 (Secondary)
Abstract

Reaction systems are a formal model that has been introduced to investigate the interactive behaviors of biochemical reactions. Based on the formal framework of reaction systems, we propose new computing models called reaction automata that feature (string) language acceptors with multiset manipulation as a computing mechanism, and show that reaction automata are computationally Turing universal. Further, some subclasses of reaction automata with space complexity are investigated and their language classes are compared to the ones in the Chomsky hierarchy., Comment: 19 pages, 6 figures

Published
2011

102. Numerical and experimental investigations of low-velocity impact on composite overwrapped pressure vessel with different stacking sequences.

Author

Akbar, Musthafa and Kobayashi, Satoshi

Subjects
*PRESSURE vessels, *DAMAGE models, *FINITE element method, *FAILURE mode & effects analysis, *IMPACT testing, *IMPACT (Mechanics), *IMPACT loads
Abstract

Composite overwrapped pressure vessels are designed to contain fluids that operate under high pressures. In addition to internal pressure, the design needs to account for out-of-plane loading in the form of low-velocity impact. In this study, a numerical analysis of four models of composite overwrapped pressure vessels with different stacking sequences is performed. A three-dimensional explicit finite element model using multi-layer stacked shell elements was used in the impact zone region to obtain reasonable computation time. Utilizing the bilinear traction-separation law, cohesive zone elements were used to simulate the delamination failure and as bonding between eight layers of CFRP covering the aluminum liner. The simulation results were then validated using drop-weight impact tests, which revealed that the response of contact force to impact time was comparable for both types of analysis. Prediction of failure was carried out by assessing the quantity of energy absorbed by the CFRP layers and was confirmed by shell element data that failed during simulations. In addition, the Hashin damage model confirmed that the matrix tensile failure mode was the predominant failure mode for all discussed impact scenarios. Model-A with Al + [90]8 stacking sequence was found to have the highest impact resistance based on the prediction of the composite's failure area and the energy absorbed by the CFRP layers. Furthermore, it was found that COPVs with combinations of helical and hoop sequences tend to have larger areas of delamination due to high interlaminar shear stress between the CFRP layers. [ABSTRACT FROM AUTHOR]

Published
2024
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103. Immediate effect of upright position on lumbar disc using multiposture MRI: Preliminary results.

Author

Furihata, Kento, Miyati, Tosiaki, Ohno, Naoki, and Kobayashi, Satoshi

Subjects
ECHO-planar imaging, INTERVERTEBRAL disk, MAGNETIC resonance imaging, LUMBAR vertebrae, DIFFUSION magnetic resonance imaging, SUPINE position
Abstract

Objectives: Gravity loading on lumbar intervertebral discs (IVDs) is affected by body position. Although the long-term effects of gravity on IVDs have been reported, the immediate effects of gravity on IVDs remain unclear. We considered that changes in IVD structure in the upright and supine positions provided new diagnostic information. Therefore, we compared the apparent diffusion coefficient (ADC), transverse relaxation time (T2), and morphology of the lumbar spine between the quickly changing upright and supine positions using an original magnetic resonance imaging (MRI) system that can obtain images in any position (multiposture MRI). Material and Methods: On a 0.4-T multiposture MRI, diffusion-weighted images of the lumbar spine in seven healthy volunteers were obtained using single-shot diffusion echo-planar imaging (b = 0 and 600 s/mm2) in quickly changing upright and supine positions. Moreover, spin-echo images with multiple echo times (echo time = 30, 60, 90, and 120 ms) were obtained in each position. We calculated the ADC and T2 of each IVD (L1 and S1) without any disc degeneration. In addition, the lumbar lordosis angle and length of the lumbar spine were measured to evaluate the morphology of the lumbar spine. Results: The T2 of the IVD between L4 and L5 in the upright position was significantly lower than that in the supine position (P < 0.05). No significant differences were observed in the ADC. The morphology of the lumbar spine did not differ significantly between the two positions. Conclusion: The T2 of the IVD between L4 and L5 was likely decreased by the effect of gravity due to the postural change from supine to upright. [ABSTRACT FROM AUTHOR]

Published
2024
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104. Validation of schedules for optimal prostate‐specific antigen monitoring after radical prostatectomy.

Author

Blas, Leandro, Shiota, Masaki, Tanegashima, Tokiyoshi, Tsukahara, Shigehiro, Ueda, Shohei, Mutaguchi, Jun, Goto, Shunsuke, Kobayashi, Satoshi, Matsumoto, Takashi, Inokuchi, Junichi, and Eto, Masatoshi

Subjects
PROSTATE-specific antigen, RADICAL prostatectomy, CANCER hospitals, SURVIVAL rate, GLEASON grading system
Abstract

Background: Early detection of biochemical recurrence (BCR) after radical prostatectomy (RP) is crucial for early treatment and improving survival outcomes. The optimal prostate‐specific antigen (PSA) monitoring remains unclear, and several models have been proposed. We aimed to externally validate four models for optimal PSA monitoring after RP and propose modifications to improve them. Methods: We reviewed the clinicopathological data of 896 patients who underwent robot‐assisted RP between 2009 and 2022. We examined all PSA values and estimated the PSA value for four monitoring schedules at each time point in the virtual follow‐up. We defined the ideal PSA for BCR detection between 0.2 and 0.4 ng/mL. Results: During the median follow‐up of 21.4 months, 128 (14.3%) patients presented BCR. The original and modified Keio models, National Cancer Center Hospital model, and American Urological Association/American Society for Radiation Oncology model detected BCR in 14 (10.9%), three (2.3%), 12 (9.4%), and 11 (8.6%) patients with PSA >0.4 ng/mL. Most patients experienced BCR detected with PSA >0.4 ng/mL during the first year postoperative. The modification of interval within 6 months postoperative avoided BCR detection with PSA >0.4 ng/mL within the first year postoperative in 8/9 (88.9%), 1/2 (50.0%), 5/6 (83.3%), and 4/4 (100%) for the original and modified Keio models, National Cancer Center Hospital model, and American Urological Association/American Society for Radiation Oncology model, respectively. Conclusion: We validated four models for PSA monitoring after RP to detect BCR and suggested modifications to avoid detections out of the desired range of PSA. These modifications could help to establish an optimal PSA monitoring schedule after RP. [ABSTRACT FROM AUTHOR]

Published
2024
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119. Multicenter Retrospective Analysis of Chemotherapy for Advanced Pancreatic Acinar Cell Carcinoma: Potential Efficacy of Platinum- and Irinotecan-Containing Regimens

Author

Takahashi, Hideaki, Ikeda, Masafumi, Shiba, Satoshi, Imaoka, Hiroshi, Todaka, Akiko, Shioji, Kazuhiko, Yane, Kei, Kojima, Yasushi, Kobayashi, Satoshi, Asagi, Akinori, Ozaka, Masato, Takada, Ryoji, Nagashio, Yoshikuni, Horiguchi, Shigeru, Kasuga, Akiyoshi, Suzuki, Eiichiro, Terashima, Takeshi, Ueno, Makoto, Morizane, Chigusa, and Furuse, Junji

Published
2021
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121. FOLFIRINOX in Pancreatic Cancer: Risk Factors for Febrile Neutropenia and Severe Neutropenia — Nationwide Study Analysis

Author

TODAKA, AKIKO, primary, SASAKI, MITSUHITO, additional, UENO, HIDEKI, additional, GOTO, TAKUMA, additional, MUROHISA, GOU, additional, MIZUNO, NOBUMASA, additional, OZAKA, MASATO, additional, KOBAYASHI, SATOSHI, additional, UESUGI, KAZUHIRO, additional, KOBAYASHI, NORITOSHI, additional, HAYASHI, HIDEYUKI, additional, SUDO, KENTARO, additional, OKANO, NAOHIRO, additional, HORITA, YOSUKE, additional, KAMEI, KEIKO, additional, NANAMI, SHOKO, additional, and BOKU, NARIKAZU, additional

Published
2023
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122. Efficient detection of somatic UBA1 variants and clinical scoring system predicting patients with variants in VEXAS syndrome

Author

Maeda, Ayaka, primary, Tsuchida, Naomi, additional, Uchiyama, Yuri, additional, Horita, Nobuyuki, additional, Kobayashi, Satoshi, additional, Kishimoto, Mitsumasa, additional, Kobayashi, Daisuke, additional, Matsumoto, Haruki, additional, Asano, Tomoyuki, additional, Migita, Kiyoshi, additional, Kato, Ayaka, additional, Mori, Ichiro, additional, Morita, Hiroyuki, additional, Matsubara, Akihiro, additional, Marumo, Yoshiaki, additional, Ito, Yuji, additional, Machiyama, Tomoaki, additional, Shirai, Tsuyoshi, additional, Ishii, Tomonori, additional, Kishibe, Mari, additional, Yoshida, Yusuke, additional, Hirata, Shintaro, additional, Akao, Satoshi, additional, Higuchi, Akitsu, additional, Rokutanda, Ryo, additional, Nagahata, Ken, additional, Takahashi, Hiroki, additional, Katsuo, Koske, additional, Ohtani, Toshio, additional, Fujiwara, Hiroshi, additional, Nagano, Hiromichi, additional, Hosokawa, Takashi, additional, Ito, Takanori, additional, Haji, Yoichiro, additional, Yamaguchi, Hiroyuki, additional, Hagino, Noboru, additional, Shimizu, Toshimasa, additional, Koga, Tomohiro, additional, Kawakami, Atsushi, additional, Kageyama, Goichi, additional, Kobayashi, Hiroshi, additional, Aoki, Akiko, additional, Mizokami, Akinari, additional, Takeuchi, Yoichi, additional, Motohashi, Rena, additional, Hagiyama, Hiroyuki, additional, Itagane, Masaki, additional, Teruya, Hiroyuki, additional, Kato, Tomohiro, additional, Miyoshi, Yuji, additional, Kise, Takayasu, additional, Yokogawa, Naoto, additional, Ishida, Takako, additional, Umeda, Naoki, additional, Isogai, Shuntaro, additional, Naniwa, Taio, additional, Yamabe, Toru, additional, Uchino, Kaori, additional, Kanasugi, Jo, additional, Takami, Akiyoshi, additional, Kondo, Yasushi, additional, Furuhashi, Kazunori, additional, Saito, Koichi, additional, Ohno, Shigeru, additional, Kishimoto, Daiga, additional, Yamamoto, Mari, additional, Fujita, Yoshiro, additional, Fujieda, Yuichiro, additional, Araki, Sachiko, additional, Tsushima, Hiroshi, additional, Misawa, Kyohei, additional, Katagiri, Akira, additional, Kobayashi, Takahiro, additional, Hashimoto, Kenichi, additional, Sone, Takehiro, additional, Hidaka, Yukiko, additional, Ida, Hiroaki, additional, Nishikomori, Ryuta, additional, Doi, Hiroshi, additional, Fujimaki, Katsumichi, additional, Akasaka, Keiichi, additional, Amano, Masako, additional, Matsushima, Hidekazu, additional, Kashino, Kaori, additional, Ohnishi, Hidenori, additional, Miwa, Yuki, additional, Takahashi, Noriyuki, additional, Takase-Minegishi, Kaoru, additional, Yoshimi, Ryusuke, additional, Kirino, Yohei, additional, Nakajima, Hideaki, additional, and Matsumoto, Naomichi, additional

Published
2023
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124. Modelling of Pollen Emission Process for Dispersal Simulation of Birch Pollen

Author

Kawashima, Shigeto, Kobayashi, Satoshi, Tanaka, Keita, Abarbanel, Henry, Series editor, Braha, Dan, Series editor, Érdi, Péter, Series editor, Friston, Karl, Series editor, Haken, Hermann, Series editor, Jirsa, Viktor, Series editor, Kacprzyk, Janusz, Series editor, Kaneko, Kunihiko, Series editor, Kelso, Scott, Series editor, Kirkilionis, Markus, Series editor, Kurths, Jürgen, Series editor, Nowak, Andrzej, Series editor, Qudrat-Ullah, Hassan, Series editor, Reichl, Linda, Series editor, Schuster, Peter, Series editor, Schweitzer, Frank, Series editor, Sornette, Didier, Series editor, Thurner, Stefan, Series editor, Steyn, Douw G., editor, and Chaumerliac, Nadine, editor

Published
2016
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128. Clinical outcomes of chemotherapy in patients with undifferentiated carcinoma of the pancreas: a retrospective multicenter cohort study

Author

Imaoka, Hiroshi, Ikeda, Masafumi, Maehara, Kosuke, Umemoto, Kumiko, Ozaka, Masato, Kobayashi, Satoshi, Terashima, Takeshi, Inoue, Hiroto, Sakaguchi, Chihiro, Tsuji, Kunihiro, Shioji, Kazuhiko, Okamura, Keiya, Kawamoto, Yasuyuki, Suzuki, Rei, Shirakawa, Hirofumi, Nagano, Hiroaki, Ueno, Makoto, Morizane, Chigusa, and Furuse, Junji

Published
2020
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129. Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer

Author

Lin, Yingsong, Nakatochi, Masahiro, Hosono, Yasuyuki, Ito, Hidemi, Kamatani, Yoichiro, Inoko, Akihito, Sakamoto, Hiromi, Kinoshita, Fumie, Kobayashi, Yumiko, Ishii, Hiroshi, Ozaka, Masato, Sasaki, Takashi, Matsuyama, Masato, Sasahira, Naoki, Morimoto, Manabu, Kobayashi, Satoshi, Fukushima, Taito, Ueno, Makoto, Ohkawa, Shinichi, Egawa, Naoto, Kuruma, Sawako, Mori, Mitsuru, Nakao, Haruhisa, Adachi, Yasushi, Okuda, Masumi, Osaki, Takako, Kamiya, Shigeru, Wang, Chaochen, Hara, Kazuo, Shimizu, Yasuhiro, Miyamoto, Tatsuo, Hayashi, Yuko, Ebi, Hiromichi, Kohmoto, Tomohiro, Imoto, Issei, Kasugai, Yumiko, Murakami, Yoshinori, Akiyama, Masato, Ishigaki, Kazuyoshi, Matsuda, Koichi, Hirata, Makoto, Shimada, Kazuaki, Okusaka, Takuji, Kawaguchi, Takahisa, Takahashi, Meiko, Watanabe, Yoshiyuki, Kuriki, Kiyonori, Kadota, Aya, Okada, Rieko, Mikami, Haruo, Takezaki, Toshiro, Suzuki, Sadao, Yamaji, Taiki, Iwasaki, Motoki, Sawada, Norie, Goto, Atsushi, Kinoshita, Kengo, Fuse, Nobuo, Katsuoka, Fumiki, Shimizu, Atsushi, Nishizuka, Satoshi S., Tanno, Kozo, Suzuki, Ken, Okada, Yukinori, Horikoshi, Momoko, Yamauchi, Toshimasa, Kadowaki, Takashi, Yu, Herbert, Zhong, Jun, Amundadottir, Laufey T., Doki, Yuichiro, Ishii, Hideshi, Eguchi, Hidetoshi, Bogumil, David, Haiman, Christopher A., Le Marchand, Loic, Mori, Masaki, Risch, Harvey, Setiawan, Veronica W., Tsugane, Shoichiro, Wakai, Kenji, Yoshida, Teruhiko, Matsuda, Fumihiko, Kubo, Michiaki, Kikuchi, Shogo, and Matsuo, Keitaro

Published
2020
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132. Early Tumor Shrinkage and Depth of Response as Predictors of Survival for Advanced Biliary Tract Cancer: An Exploratory Analysis of JCOG1113.

Author

Okano, Naohiro, Morizane, Chigusa, Okusaka, Takuji, Sadachi, Ryo, Kataoka, Tomoko, Kobayashi, Satoshi, Ikeda, Masafumi, Ozaka, Masato, Mizutani, Tomonori, Sugimori, Kazuya, Todaka, Akiko, Shimizu, Satoshi, Mizuno, Nobumasa, Yamamoto, Tomohisa, Sano, Keiji, Tobimatsu, Kazutoshi, Katanuma, Akio, Gotoh, Kunihito, Yamaguchi, Hironori, and Ishii, Hiroshi

Subjects
DISEASE progression, BILE duct tumors, CONFIDENCE intervals, CANCER chemotherapy, MULTIVARIATE analysis, TREATMENT effectiveness, GEMCITABINE, RESEARCH funding, CISPLATIN, PROGRESSION-free survival, TUMOR markers, PROPORTIONAL hazards models, OVERALL survival, EVALUATION
Abstract

Background Recent studies suggest that early tumor shrinkage (ETS) and depth of response (DpR) reflect outcomes of chemotherapy in various cancers. This study evaluated the association of ETS and DpR with clinical outcomes using data from JCOG1113, which demonstrated the non-inferiority of gemcitabine plus S-1 (GS) to gemcitabine plus cisplatin (GC) for chemotherapy-naïve advanced biliary tract cancer. Material and Methods In total, 354 (289 with measurable target lesions) patients enrolled in JCOG1113 were divided into ETS-unachieved and ETS-achieved groups (≥20% tumor reduction at week 6) and DpR-low and DpR-high groups (≥40% maximum shrinkage) until 12 weeks after enrollment. The impact of ETS and DpR on survival outcome was evaluated using the multivariable Cox proportional hazard model. Results The proportions of patients in the ETS-achieved and DpR-high groups were similar between the 2 treatment arms. The hazard ratios (HRs) of progression-free survival (PFS) and overall survival (OS) for the ETS-achieved group were 0.70 (95% confidence interval (CI), 0.52-0.93) and 0.60 (95%CI, 0.44-0.81), respectively. The HRs of PFS and OS for the DpR-high group were 0.67 (95%CI, 0.48-0.94) and 0.64 (95%CI, 0.46-0.90), respectively. In the subpopulation treatment effect pattern plot analysis, most patients in the ETS-achieved group in the GC arm did not experience disease progression after 12 weeks from the landmark. Conclusion As on-treatment markers, ETS and DpR were effective tools. ETS was clinically useful, because it can be used to evaluate the outcomes of treatment early at a specific time. [ABSTRACT FROM AUTHOR]

Published
2024
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133. A Multicenter Retrospective Study of Gemcitabine Plus Nab-Paclitaxel for Elderly Patients With Advanced Pancreatic Cancer

Author

Kobayashi, Satoshi, Ueno, Makoto, Ikeda, Masafumi, Ozaka, Masato, Sano, Yusuke, Hirotani, Akane, Tozuka, Yuichiro, Fukushima, Taito, Tezuka, Shun, Moriya, Satoshi, Umemoto, Kumiko, Watanabe, Kazuo, Sasaki, Mitsuhito, Hashimoto, Yusuke, Imaoka, Hiroshi, Ohno, Izumi, Mitsunaga, Shuichi, Yamada, Ikuhiro, Sasaki, Takashi, Sasahira, Naoki, and Morimoto, Manabu

Published
2020
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135. Multi-center clinical evaluation of streptozocin-based chemotherapy for advanced pancreatic neuroendocrine tumors in Japan: focus on weekly regimens and monotherapy

Author

Shibuya, Hitoshi, Hijioka, Susumu, Sakamoto, Yasunari, Ito, Tetsuhide, Ueda, Keijiro, Komoto, Izumi, Kobayashi, Noritoshi, Kudo, Atsushi, Yasuda, Hiroaki, Miyake, Hayato, Arita, Junichi, Kiritani, Sho, Ikeda, Masafumi, Imaoka, Hiroshi, Ueno, Makoto, Kobayashi, Satoshi, Furuta, Mitsuhiro, Nagashio, Yoshikuni, Murohisa, Gou, Aoki, Taku, Matsumoto, Shigemi, Motoya, Masayo, Azemoto, Nobuaki, Itakura, Jun, Horiguchi, Shigeru, Yogi, Tatsuji, Kawagoe, Tetsuro, Miyaoka, Youichi, Imamura, Fumito, Senju, Michio, Arioka, Hitoshi, Hara, Kazuo, Imamura, Masayuki, and Okusaka, Takuji

Published
2018
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140. 社会を見つめ，社会と関わる力を育成する社会科授業の開発―小・中学校における「社会的な見方・考え方」の接続・発展に着目して―

Author

KOBAYASHI, Satoshi, KAWAKAMI, Takeshi, AOYAGI, Tadaomi, TANAKA, Kaori, YOSHINAGA, Takaomi, KUMADA, Teisuke, TAMEIKE, Yoshihiro, and MATSUMIRA, Keiko

Subjects
接続・発展, 中学校社会科, 「社会的な見方・考え方」, 関連性, 小学校社会科
Abstract

text, 紀要論文 / Departmental Bulletin Paper, 本稿では，小・中学校社会科において「社会的な見方・考え方」を働かせた学習を位置づけた単元・授業として，「益子焼を生かした益子町のまちづくり」（小学校第4学年）および「日本の諸地域～北海道地方～」（中学校第2学年地理的分野）の実践事例について，単元・授業の実際と子どもたちの学びの姿について紹介，分析した。また，これまでの4年間における実践・研究を通して，各学年（分野）・単元・授業において「社会的な見方・考え方」の接続・発展や関連性を意識しながら適切に位置づけることで，子どもたちの多面的・多角的な学びや「深い学び」の実現に資する可能性があることが確認された。

Published
2022

141. Risk Factors for Early Recurrence in Patients with Pancreatic Ductal Adenocarcinoma who Underwent Curative Resection

Author

Murakawa, Masaaki, primary, Kawahara, Shinnosuke, additional, Takahashi, Daishi, additional, Kamioka, Yuto, additional, Yamamoto, Naoto, additional, Kobayashi, Satoshi, additional, Ueno, Makoto, additional, Morimoto, Manabu, additional, Sawazaki, Sho, additional, Tamagawa, Hiroshi, additional, Ohshima, Takashi, additional, Yukawa, Norio, additional, Rino, Yasushi, additional, and Morinaga, Soichiro, additional

Published
2023
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144. Quality-Of-Life Survey of Pancreatic Cancer Patients: A Comparison Between General Public and Physicians

Author

Sasahara, Yuriko, primary, Takumoto, Yuki, additional, Watanabe, Kaname, additional, Takeda, Hiroyuki, additional, Umemoto, Kumiko, additional, Sunakawa, Yu, additional, Suzuki, Naoki, additional, Yoshioka, Takashi, additional, Kobayashi, Satoshi, additional, Ueno, Makoto, additional, Nakamura, Sho, additional, Akazawa, Manabu, additional, and Narimatsu, Hiroto, additional

Published
2023
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145. Association Between Immune-Related Adverse Events and Survival in Patients with Hepatocellular Carcinoma Treated With Atezolizumab Plus Bevacizumab

Author

Fukushima, Taito, primary, Morimoto, Manabu, additional, Kobayashi, Satoshi, additional, Ueno, Makoto, additional, Uojima, Haruki, additional, Hidaka, Hisashi, additional, Kusano, Chika, additional, Chuma, Makoto, additional, Numata, Kazushi, additional, Tsuruya, Kota, additional, Arase, Yoshitaka, additional, Kagawa, Tatehiro, additional, Hattori, Nobuhiro, additional, Ikeda, Hiroki, additional, Watanabe, Tsunamasa, additional, Tanaka, Katsuaki, additional, and Maeda, Shin, additional

Published
2023
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146. Abstract 6686: Tumor suppressor miRNA-665 based serum biomarker for detecting pancreatobiliary cancer

Author

Mitsunaga, Shuichi, primary, Ueno, Makoto, additional, Tsuda, Masahiro, additional, Kuwahara, Takamichi, additional, Takayama, Yukiko, additional, Hanada, Keiji, additional, Yoshida, Hitoshi, additional, Takahashi, Kenji, additional, Nakata, Kohei, additional, Iwama, Hideaki, additional, Ikeda, Masafumi, additional, Kobayashi, Satoshi, additional, Miki, Ikuya, additional, Hara, Kazuo, additional, Higuchi, Ryota, additional, Shimizu, Akinori, additional, Nomoto, Tomohiro, additional, Iwamoto, Hidetaka, additional, Nakamura, Masafumi, additional, Hatano, Etsuro, additional, Sudo, Hiroko, additional, Takizawa, Satoko, additional, and Ochiai, Atsushi, additional

Published
2023
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