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101. 826 - Simulation in urological training and education (SIMULATE): A randomised controlled clinical and educational trial to determine the effect of structured surgical simulation training

Author

Aydin, A., Ahmed, K., Raison, N., Abe, T., Gözen, A.S., Moltzahn, F., Knoll, T., Zhu, W., Kunit, T., Skolarikos, A., Sfakianos, J., Lantz, A., Chew, B., Thalmann, G., Rassweiler, J., Shinohara, N., Tewari, A., Zeng, G., Sarıca, K., Van Hemelrijck, M., Ahmed, H.U., Khan, M.S., and Dasgupta, P.

Published
2019
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103. First clinical evaluation of a new innovative ureteral access sheath (Re-Trace (TM)): a European study

Author

Doizi, S, Knoll, T, Scoffone, CM, Breda, A, Brehmer, M, Liatsikos, E, Cornu, JN, and Traxer, O

Subjects
Ureterorenoscopy, Endourology, Ureteral access sheath, Clinical research
Abstract

The use of a ureteral access sheath (UAS) during flexible retrograde intrarenal surgery (RIRS) has become increasingly popular. Our aim was to evaluate the accessibility of a new UAS device, allowing the transformation of the working guidewire into a safety guidewire. A prospective, multicenter study was conducted between January and February 2010 in six European tertiary reference centers. Patients needing flexible RIRS were eligible to participate in the study. In all cases, insertion of the Re-Trace (TM) (12/14Fr, Coloplast, Denmark) was attempted at the beginning of the procedure. Insertion success was defined as placement of the UAS in the lumbar ureter with successful disengagement of the working guidewire, which turned into a safety guidewire. Influence of gender and pre-stenting status was analyzed by univariate analysis. 137 UASs were used in 75 male and 62 female patients. 25.5 % of ureters were pre-stented: men were 2.17 more often pre-stented than women. The overall Re-Trace (TM) insertion rate was 82.5 %. Success rate was not significantly different between men and women (77.3 vs. 88.7 %, respectively, p = 0.11). Pre-stenting status did not significantly influence the success rate (p = 0.31). When analyzing the combined influence of pre-stenting status and gender, the worst success rates seemed to be obtained in men without pre-stenting, but no significant differences were found between groups. Re-Trace (TM) UAS showed good overall insertion rates. This evaluation validated the new concept of guidewire disengagement: A single wire automatically switches from working to safety role.

Published
2014

105. Steindiagnostik 2016

Author

Neisius, A., primary, Thomas, C., additional, Roos, F. C., additional, Jäger, W., additional, Tsaur, I., additional, Bartsch, G., additional, Knoll, T., additional, and Haferkamp, A., additional

Published
2016
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114. Improving reaction and mixing times in macro- and microfluidic devices for medical applications

Author

Cardoso, V. F., Knoll, T., Velten, T., Minas, Graça, Lanceros-Méndez, S., and Universidade do Minho

Subjects
Lab-on-a-chip, Piezoelectric polymers
Abstract

A major concern in the development of lab-on-a-chip devices is the need to develop systems allowing efficient pumping and mixing of fluids in sub-micrometer channels. This work reports on an actuator system based on piezoelectric polymers able to improve reaction and mixing times both in macro- and micro-medical devices. Transparent piezoelectric actuators based on poly(vinylidene fluoride) and copolymers have been deposited by spin coating and optimized for the specific applications. The preparation process of the actuator system will be discussed as well as its implementation into macro- and microfluidic systems. The efficiency in improving mixing reaction times, which strongly depends on the specific reaction, can be as large as 71%., Work supported by FCT- Fundação para a Ciência e a Tecnologia (NANO/NMed-SD/0156/2007, PTDC/BIO/70017/2006, and PTDC/CTM/69316/2006 and SFRH/BD/44289/2008 grants).

Published
2011

124. Stoßwellenlithotripsie in Deutschland

Author

Schnabel, M.J., primary, Brummeisl, W., additional, Burger, M., additional, Rassweiler, J.J., additional, Knoll, T., additional, Neisius, A., additional, Chaussy, C.G., additional, and Fritsche, H.M., additional

Published
2015
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125. EAU Policy on Live Surgery Events

Author

Artibani, W., Ficarra, V., Challacombe, B.J., Abbou, C.C., Bedke, J., Boscolo-Berto, R., Brausi, M., Rosette, J.J.M.H.C. de la, Deger, S., Denis, L., Guazzoni, G., Guillonneau, B., Heesakkers, J.P.F.A., Jacqmin, D., Knoll, T., Martinez-Pineiro, L., Montorsi, F., Mottrie, A., Piechaud, P.T., Rane, A., Rassweiler, J., Stenzl, A., Moorselaar, J. van, Velthoven, R.F. van, Poppel, H. van, Wirth, M., Abrahamsson, P.A., Parsons, K.F., Artibani, W., Ficarra, V., Challacombe, B.J., Abbou, C.C., Bedke, J., Boscolo-Berto, R., Brausi, M., Rosette, J.J.M.H.C. de la, Deger, S., Denis, L., Guazzoni, G., Guillonneau, B., Heesakkers, J.P.F.A., Jacqmin, D., Knoll, T., Martinez-Pineiro, L., Montorsi, F., Mottrie, A., Piechaud, P.T., Rane, A., Rassweiler, J., Stenzl, A., Moorselaar, J. van, Velthoven, R.F. van, Poppel, H. van, Wirth, M., Abrahamsson, P.A., and Parsons, K.F.

Abstract

Item does not contain fulltext, CONTEXT: Live surgery is an important part of surgical education, with an increase in the number of live surgery events (LSEs) at meetings despite controversy about their real educational value, risks to patient safety, and conflicts of interest. OBJECTIVE: To provide a European Association of Urology (EAU) policy on LSEs to regulate their organisation during urologic meetings. EVIDENCE ACQUISITION: The project was carried out in phases: a systematic literature review generating key questions, surveys sent to Live Surgery Panel members, and Internet- and panel-based consensus finding using the Delphi process to agree on and formulate a policy. EVIDENCE SYNTHESIS: The EAU will endorse LSEs, provided that the EAU Code of Conduct for live surgery and all organisational requirements are followed. Outcome data must be submitted to an EAU Web-based registry and complications reported using the revised Martin criteria. Regular audits will take place to evaluate compliance as well as the educational role of live surgery. CONCLUSIONS: This policy represents the consensus view of an expert panel established to advise the EAU. The EAU recognises the educational role of live surgery and endorses live case demonstration at urologic meetings that are conducted within a clearly defined regulatory framework. The overriding principle is that patient safety must take priority over all other considerations in the conduct of live surgery. PATIENT SUMMARY: Controversy exists regarding the true educational value of live surgical demonstrations on patients at surgical meetings. An EAU committee of experts developed a policy on how best to conduct live surgery at urologic meetings. The key principle is to ensure safety for every patient, including a code of conduct and checklist for live surgery, specific rules for how the surgery is organised and performed, and how each patient's results are reported to the EAU. For detailed information, please visit www.uroweb.org.

Published
2014

129. Intelligent intraoral drug delivery microsystem

Author

Velten, T., Schuck, H., Knoll, T., Scholz, O., Schumacher, A., Göttsche, T., Wolff, A., Beiski, B.Z., and Publica

Abstract

The authors report on the concept and development of an intelligent intraoral drug delivery microsystem, that provides an alternative approach for the treatment of addiction and chronic diseases. The drug delivery system (DDS) comprises a medication replacement reservoir, a medication release mechanism, a built-in intelligence, a remote control, microsensors, and microactuators. It is thus able to release the medication in a controlled manner according to the patient needs. The emphasis of this article is on the application of sensors and microfluidic components in a real microsystem and also showing some details of two system components, namely, the osmotic pump and the flow sensor. The motivation for the microfluidic approach, the concept of the DDS, the requirements for this specific application, and the arising problems will be presented and discussed. Regarding the sensors and actuators, the problems mainly concern size and power consumption. A major challenging aspect of microfluidic component development is to avoid clogging of small channels because of particles and recrystallization of saturated fluids.

Published
2006

136. The use of mannitol in partial and live donor nephrectomy: an international survey

Author

Cosentino, M, Breda, A, Sanguedolce, F, Landman, J, Stolzenburg, J, Verze, P, Rassweiler, J, Van Poppel, H, Klingler, Hc, Janetschek, G, Celia, A, Kim, Fj, Thalmann, G, Nagele, U, Mogorovich, A, Bolenz, C, Knoll, T, Porpiglia, F, Alvarez Maestro, M, Francesca, F, Deho, F, Eggener, S, Abbou, C, Meng, Mv, Aron, M, Laguna, P, Mladenov, D, D'Addessi, Alessandro, Bove, P, Schiavina, R, De Cobelli, O, Merseburger, A, Dalpiaz, O, D'Ancona, Fch, Polascik, Tj, Muschter, R, Leppert, Tj, Villavicencio, H., D'Addessi, Alessandro (ORCID:0000-0002-9155-7319), Cosentino, M, Breda, A, Sanguedolce, F, Landman, J, Stolzenburg, J, Verze, P, Rassweiler, J, Van Poppel, H, Klingler, Hc, Janetschek, G, Celia, A, Kim, Fj, Thalmann, G, Nagele, U, Mogorovich, A, Bolenz, C, Knoll, T, Porpiglia, F, Alvarez Maestro, M, Francesca, F, Deho, F, Eggener, S, Abbou, C, Meng, Mv, Aron, M, Laguna, P, Mladenov, D, D'Addessi, Alessandro, Bove, P, Schiavina, R, De Cobelli, O, Merseburger, A, Dalpiaz, O, D'Ancona, Fch, Polascik, Tj, Muschter, R, Leppert, Tj, Villavicencio, H., and D'Addessi, Alessandro (ORCID:0000-0002-9155-7319)

Abstract

PURPOSE: Animal studies have shown the potential benefits of mannitol as renoprotective during warm ischemia; it may have antioxidant and anti-inflammatory properties and is sometimes used during partial nephrectomy (PN) and live donor nephrectomy (LDN). Despite this, a prospective study on mannitol has never been performed. The aim of this study is to document patterns of mannitol use during PN and LDN. MATERIALS AND METHODS: A survey on the use of mannitol during PN and LDN was sent to 92 high surgical volume urological centers. Questions included use of mannitol, indications for use, physician responsible for administration, dosage, timing and other renoprotective measures. RESULTS: Mannitol was used in 78 and 64 % of centers performing PN and LDN, respectively. The indication for use was as antioxidant (21 %), as diuretic (5 %) and as a combination of the two (74 %). For PN, the most common dosages were 12.5 g (30 %) and 25 g (49 %). For LDN, the most common doses were 12.5 g (36.3 %) and 25 g (63.7 %). Overall, 83 % of centers utilized mannitol, and two (percent or centers??) utilized furosemide for renoprotection. CONCLUSIONS: A large majority of high-volume centers performing PN and LDN use mannitol for renoprotection. Since there are no data proving its value nor standardized indication and usage, this survey may provide information for a randomized prospective study.

Published
2012

139. 1067 Post-ureteroscopic lesion scale: Multicentre video-based evaluation of inter-rater reliability

Author

Schoenthaler, M., primary, Buchholz, N., additional, Farin, E., additional, Ather, H., additional, Bach, C., additional, Bach, T., additional, Denstedt, J.D., additional, Fritsche, H.-M., additional, Grasso, M., additional, Hakenberg, O., additional, Herwig, R., additional, Knoll, T., additional, Kuehhas, F.E., additional, Liatsikos, E., additional, Liske, P., additional, Osther, P.J.S., additional, Reis-Santos, J.M., additional, Sarica, K., additional, Seitz, C., additional, Straub, M., additional, Traxer, O., additional, Trinchieri, A., additional, Turney, B., additional, and Miernik, A., additional

Published
2013
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141. The use of mannitol in partial and live donor nephrectomy: an international survey

Author

Cosentino, M., primary, Breda, A., additional, Sanguedolce, F., additional, Landman, J., additional, Stolzenburg, J.-U., additional, Verze, P., additional, Rassweiler, J., additional, Van Poppel, H., additional, Klingler, H. C., additional, Janetschek, G., additional, Celia, A., additional, Kim, F. J., additional, Thalmann, G., additional, Nagele, U., additional, Mogorovich, A., additional, Bolenz, C., additional, Knoll, T., additional, Porpiglia, F., additional, Alvarez-Maestro, M., additional, Francesca, F., additional, Deho, F., additional, Eggener, S., additional, Abbou, C., additional, Meng, M. V., additional, Aron, M., additional, Laguna, P., additional, Mladenov, D., additional, D’Addessi, A., additional, Bove, P., additional, Schiavina, R., additional, De Cobelli, O., additional, Merseburger, A. S., additional, Dalpiaz, O., additional, D’Ancona, F. C. H., additional, Polascik, T. J., additional, Muschter, R., additional, Leppert, T. J., additional, and Villavicencio, H., additional

Published
2012
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142. Wie lautet Ihre Diagnose?

Author

Knoll T

Subjects
medicine.medical_specialty, Distal renal tubular acidosis, business.industry, Urology, Medicine, General Medicine, business, medicine.disease
Published
2004

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