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560 results on '"Klivényi, Péter"'

102. Neuronal and glial CSF biomarkers in multiple sclerosis

Author

Momtazmanesh Sara, Shobeiri Parnian, Saghazadeh Amene, Teunissen Charlotte E., Burman Joachim, Szalárdy Levente, Klivényi Péter, Bartos Ales, Fernandes Adelaide, and Rezaei Nima

Subjects
03.01. Általános orvostudomány
Published
2021

103. Additional file 1 of Genetic epidemiological characteristics of a Hungarian subpopulation of patients with Huntington’s disease

Author

Despotov, Katalin, Zádori, Dénes, Veres, Gábor, Jakab, Katalin, Gárdián, Gabriella, Tóth, Eszter, Kincses, Tamás Zsigmond, Vécsei, László, Ajtay, András, Bereczki, Dániel, and Klivényi, Péter

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, mental disorders
Abstract

Additional file 1. Composition of the control group. This flowchart illustrates the individuals with CAG repeat lengths in the non-pathological range (

Published
2021
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104. Additional file 2 of Genetic epidemiological characteristics of a Hungarian subpopulation of patients with Huntington’s disease

Author

Despotov, Katalin, Zádori, Dénes, Veres, Gábor, Jakab, Katalin, Gárdián, Gabriella, Tóth, Eszter, Kincses, Tamás Zsigmond, Vécsei, László, Ajtay, András, Bereczki, Dániel, and Klivényi, Péter

Abstract

Additional file 2. Symptomatic control group individuals with biallelic wild-type genotypes. This table describes the clinical presentation of individuals tested for differential diagnostic purposes and were found to carry alleles with repeat lengths

Published
2021
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107. Two Classes of T1 Hypointense Lesions in Multiple Sclerosis With Different Clinical Relevance

Author

Kocsis, Krisztián, primary, Szabó, Nikoletta, additional, Tóth, Eszter, additional, Király, András, additional, Faragó, Péter, additional, Kincses, Bálint, additional, Veréb, Dániel, additional, Bozsik, Bence, additional, Boross, Katalin, additional, Katona, Melinda, additional, Bodnár, Péter, additional, László, Nyúl Gábor, additional, Vécsei, László, additional, Klivényi, Péter, additional, Bencsik, Krisztina, additional, and Kincses, Zsigmond Tamás, additional

Published
2021
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115. Web‐based decision support system for patient‐tailored selection of antiseizure medication in adolescents and adults: An external validation study.

Author

Hadady, Levente, Klivényi, Péter, Perucca, Emilio, Rampp, Stefan, Fabó, Dániel, Bereczki, Csaba, Rubboli, Guido, Asadi‐Pooya, Ali A., Sperling, Michael R., and Beniczky, Sándor

Subjects
*DECISION support systems, *MEDICAL personnel, *PROPENSITY score matching, *DRUG allergy, *TEENAGERS
Abstract

Background and purpose: Antiseizure medications (ASMs) should be tailored to individual characteristics, including seizure type, age, sex, comorbidities, comedications, drug allergies, and childbearing potential. We previously developed a web‐based algorithm for patient‐tailored ASM selection to assist health care professionals in prescribing medication using a decision support application (https://epipick.org). In this validation study, we used an independent dataset to assess whether ASMs recommended by the algorithm are associated with better outcomes than ASMs considered less desirable by the algorithm. Methods: Four hundred twenty‐five consecutive patients with newly diagnosed epilepsy were followed for at least 1 year after starting an ASM chosen by their physician. Patient characteristics were fed into the algorithm, blinded to the physician's ASM choices and outcome. The algorithm recommended ASMs, ranked in hierarchical groups, with Group 1 ASMs labeled as the best option for that patient. We evaluated retention rates, seizure freedom rates, and adverse effects leading to treatment discontinuation. Survival analysis contrasted outcomes between patients who received favored drugs and those who received lower ranked drugs. Propensity score matching corrected for possible imbalances between the groups. Results: Antiseizure medications classified by the algorithm as best options had a higher retention rate (79.4% vs. 67.2%, p = 0.005), higher seizure freedom rate (76.0% vs. 61.6%, p = 0.002), and lower rate of discontinuation due to adverse effects (12.0% vs. 29.2%, p < 0.001) than ASMs ranked as less desirable by the algorithm. Conclusions: Use of the freely available decision support system is associated with improved outcomes. This drug selection application can provide valuable assistance to health care professionals prescribing medication for individuals with epilepsy. [ABSTRACT FROM AUTHOR]

Published
2022
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120. Altered brain network function during attention-modulated visual processing in multiple sclerosis

Author

Veréb, Dániel, primary, Tóth, Eszter, additional, Bozsik, Bence, additional, Király, András, additional, Szabó, Nikoletta, additional, Kincses, Bálint, additional, Kocsis, Krisztián, additional, Faragó, Péter, additional, László, Vécsei, additional, Bencsik, Krisztina, additional, Klivényi, Péter, additional, and Kincses, Zsigmond Tamás, additional

Published
2020
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129. Légzési elégtelenséggel járó CANOMAD szindróma

Author

Salamon, András, primary, Dézsi, Lívia, additional, Radics, Bence, additional, Varga, Edina Tímea, additional, Hortobágyi, Tibor, additional, Tömösvári, Adrienn, additional, Vécsei, László, additional, Klivényi, Péter, additional, and Rajda, Cecília, additional

Published
2020
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130. Late simultaneous carcinomatous meningitis, temporal bone infiltrating macro-metastasis and disseminated multi-organ micro-metastases presenting with mono-symptomatic vertigo – a clinico-pathological case reporT

Author

Jarabin, János András, primary, Klivényi, Péter, additional, Tiszlavicz, László, additional, Molnár, Fiona Anna, additional, Gion, Katalin, additional, Földesi, Imre, additional, Kiss, József Géza, additional, Rovó, László, additional, and Bella, Zsolt, additional

Published
2020
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131. Az előrehaladott Parkinson-kór jellemzői a klinikai gyakorlatban: az OBSERVE-PD vizsgálat eredményei és a magyarországi alcsoport elemzése

Author

Takáts, Annamária, primary, Aschermann, Zsuzsanna, additional, Vécsei, László, additional, Klivényi, Péter, additional, Dézsi, Lívia, additional, Zádori, Dénes, additional, Valikovics, Attila, additional, Varannai, Lajos, additional, Onuk, Koray, additional, Kinczel, Beatrix, additional, and Kovács, Norbert, additional

Published
2020
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137. Altered brain network function during attention-modulated visual processing in multiple sclerosis.

Author

Veréb, Dániel, Tóth, Eszter, Bozsik, Bence, Király, András, Szabó, Nikoletta, Kincses, Bálint, Kocsis, Krisztián, Faragó, Péter, László, Vécsei, Bencsik, Krisztina, Klivényi, Péter, and Kincses, Zsigmond Tamás

Subjects
MAGNETIC resonance imaging, MULTIPLE sclerosis, COGNITIVE ability, EXECUTIVE function, TASK performance
Abstract

Background: Multiple sclerosis may damage cognitive performance in several domains, including attention. Although attention network deficits were described during rest, studies that investigate their function during task performance are scarce. Objective: To investigate connectivity within and between task-related networks in multiple sclerosis during a visual attention task as a function of cognitive performance. Methods: A total of 23 relapsing-remitting multiple sclerosis (RRMS) patients and 29 healthy controls underwent task-functional magnetic resonance imaging (fMRI) scans using a visual attention paradigm on a 3T scanner. Scans were analysed using tensor-independent component analysis (TICA). Functional connectivity was calculated within and between components. We assessed cognitive function with the Brief International Cognitive Assessment for MS (BICAMS) battery. Results: TICA extracted components related to visual processing, attention, executive function and the default-mode network. Subject scores of visual/attention-related and executive components were greater in healthy controls (p < 0.032, p < 0.023). Connectivity between visual/attention-related and default-mode components was higher in patients (p < 0.043), correlating with Brief Visuospatial Memory Test–Revised (BVMT-R) scores (R = −0.48, p < 0.036). Patients showed reduced connectivity between the right intraparietal sulcus (rIPS) and frontal eye field (rFEF), and bilateral frontal eye fields (p < 0.012, p < 0.003). Reduced rIPS-rFEF connectivity came with lower Symbol Digit Modalities Test (SDMT)/BVMT-R scores in patients (R = 0.53, p < 0.02, R = 0.46, p < 0.049). Conclusion: Attention-related networks show altered connectivity during task performance in RRMS patients, scaling with cognitive disability. [ABSTRACT FROM AUTHOR]

Published
2021
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140. The Role of Genetic Testing in the Clinical Practice and Research of Early-Onset Parkinsonian Disorders in a Hungarian Cohort: Increasing Challenge in Genetic Counselling, Improving Chances in Stratification for Clinical Trials

Author

Illés, Anett, primary, Csabán, Dóra, additional, Grosz, Zoltán, additional, Balicza, Péter, additional, Gézsi, András, additional, Molnár, Viktor, additional, Bencsik, Renáta, additional, Gál, Anikó, additional, Klivényi, Péter, additional, and Molnar, Maria Judit, additional

Published
2019
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141. Predominant neurological phenotype in a Hungarian family with two novel mutations in the XPA gene—case series

Author

Zádori, Dénes, primary, Szpisjak, László, additional, Németh, István Balázs, additional, Reisz, Zita, additional, Kovacs, Gabor G., additional, Szépfalusi, Noémi, additional, Németh, Viola Luca, additional, Maróti, Zoltán, additional, Tóth-Molnár, Edit, additional, Oláh, Judit, additional, Vécsei, László, additional, Klivényi, Péter, additional, and Kalmár, Tibor, additional

Published
2019
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146. Multiplex ischaemiás stroke Osler-Rendu-Weber-kórban

Author

Salamon, András, primary, Faragó, Péter, additional, Németh, Viola Luca, additional, Szépfalusi, Noémi, additional, Horváth, Emese, additional, Vass, Andrea, additional, Bereczky, Zsuzsanna, additional, Tajti, János, additional, Vécsei, László, additional, Klivényi, Péter, additional, and Zádori, Dénes, additional

Published
2019
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149. Neurotransmitter and tryptophan metabolite concentration changes in the complete Freund's adjuvant model of orofacial pain.

Author

Cseh, Edina K., Veres, Gábor, Körtési, Tamás, Polyák, Helga, Nánási, Nikolett, Tajti, János, Párdutz, Árpád, Klivényi, Péter, Vécsei, László, and Zádori, Dénes

Subjects
TRYPTOPHAN metabolism, AMINO acids, ANIMAL experimentation, FACIAL pain, HIGH performance liquid chromatography, METABOLITES, NEURONS, NEUROTRANSMITTERS, RATS, SEROTONIN, STATISTICS, T-test (Statistics), DATA analysis
Abstract

Background: The neurochemical background of the evolution of headache disorders, still remains partially undiscovered. Accordingly, our aim was to further explore the neurochemical profile of Complete Freund's adjuvant (CFA)-induced orofacial pain, involving finding the shift point regarding small molecule neurotransmitter concentrations changes vs. that of the previously characterized headache-related neuropeptides. The investigated neurotransmitters consisted of glutamate, γ-aminobutyric acid, noradrenalin and serotonin. Furthermore, in light of its influence on glutamatergic neurotransmission, we measured the level of kynurenic acid (KYNA) and its precursors in the kynurenine (KYN) pathway (KP) of tryptophan metabolism. Methods: The effect of CFA was evaluated in male Sprague Dawley rats. Animals were injected with CFA (1 mg/ml, 50 μl/animal) into the right whisker pad. We applied high-performance liquid chromatography to determine the concentrations of the above-mentioned compounds from the trigeminal nucleus caudalis (TNC) and somatosensory cortex (ssCX) of rats. Furthermore, we measured some of these metabolites from the cerebrospinal fluid and plasma as well. Afterwards, we carried out permutation t-tests as post hoc analysis for pairwise comparison. Results: Our results demonstrated that 24 h after CFA treatment, the level of glutamate, KYNA and that of its precursor, KYN was still elevated in the TNC, all diminishing by 48 h. In the ssCX, significant concentration increases of KYNA and serotonin were found. Conclusion: This is the first study assessing neurotransmitter changes in the TNC and ssCX following CFA treatment, confirming the dominant role of glutamate in early pain processing and a compensatory elevation of KYNA with anti-glutamatergic properties. Furthermore, the current findings draw attention to the limited time interval where medications can target the glutamatergic pathways. [ABSTRACT FROM AUTHOR]

Published
2020
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150. CANOMAD SYNDROME WITH RESPIRATORY FAILURE.

Author

SALAMON, András, DÉZSI, Lívia, RADICS, Bence, VARGA, Edina Tímea, HORTOBÁGYI, Tibor, TÖMÖSVÁRI, Adrienn, VÉCSEI, László, KLIVÉNYI, Péter, and RAJDA, Cecília

Subjects
RESPIRATORY insufficiency, B cells, EYE paralysis, GANGLIOSIDES, INTRAVENOUS immunoglobulins
Abstract

Copyright of Clinical Neuroscience / Ideggyógyászati Szemle is the property of LifeTime Media Kft. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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