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1,438 results on '"Kim, Hyun-Jun"'

107. High‐Performance Solution‐Processed 2D P‐Type WSe 2 Transistors and Circuits through Molecular Doping

Author

Zou, Taoyu, primary, Kim, Hyun‐Jun, additional, Kim, Soonhyo, additional, Liu, Ao, additional, Choi, Min‐Yeong, additional, Jung, Haksoon, additional, Zhu, Huihui, additional, You, Insang, additional, Reo, Youjin, additional, Lee, Woo‐Ju, additional, Kim, Yong‐Sung, additional, Kim, Cheol‐Joo, additional, and Noh, Yong‐Young, additional

Published
2022
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134. Error-Based Collaborative Filtering Algorithm for Top-N Recommendation

Author

Kim, Heung-Nam, Ji, Ae-Ttie, Kim, Hyun-Jun, Jo, Geun-Sik, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Rangan, C. Pandu, editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Dong, Guozhu, editor, Lin, Xuemin, editor, Wang, Wei, editor, Yang, Yun, editor, and Yu, Jeffrey Xu, editor

Published
2007
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136. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

Author

Huang, Menggui, Liu, Tianrun, Ma, Peihong, Mitteer, Jr., R. Alan, Zhang, Zhenting, Kim, Hyun Jun, Yeo, Eujin, Zhang, Duo, Cai, Peiqiang, Li, Chunsheng, Zhang, Lin, Zhao, Botao, Roccograndi, Laura, O'Rourke, Donald M., Dahmane, Nadia, Gong, Yanqing, Koumenis, Constantinos, and Fan, Yi

Subjects
Neovascularization -- Analysis -- Health aspects, Glioblastoma multiforme -- Development and progression -- Analysis -- Care and treatment, Permeability -- Analysis, Health care industry
Abstract

Aberrant vascularization is a hallmark of cancer progression and treatment resistance. Here, we have shown that endothelial cell (EC) plasticity drives aberrant vascularization and chemoresistance in glioblastoma multiforme (GBM). By utilizing human patient specimens, as well as allograft and genetic murine GBM models, we revealed that a robust endothelial plasticity in GBM allows acquisition of fibroblast transformation (also known as endothelial mesenchymal transition [Endo-MT]), which is characterized by EC expression of fibroblast markers, and determined that a prominent population of GBM-associated fibroblast-like cells have EC origin. Tumor ECs acquired the mesenchymal gene signature without the loss of EC functions, leading to enhanced cell proliferation and migration, as well as vessel permeability. Furthermore, we identified a c-Met/ETS-1/matrix metalloproteinase-14 (MMP-14) axis that controls VE-cadherin degradation, Endo-MT, and vascular abnormality. Pharmacological c-Met inhibition induced vessel normalization in patient tumor-derived ECs. Finally, EC-specific KO of Met inhibited vascular transformation, normalized blood vessels, and reduced intratumoral hypoxia, culminating in suppressed tumor growth and prolonged survival in GBM-bearing mice after temozolomide treatment. Together, these findings illustrate a mechanism that controls aberrant tumor vascularization and suggest that targeting Endo-MT may offer selective and efficient strategies for antivascular and vessel normalization therapies in GBM, and possibly other malignant tumors., Introduction Overgrown, abnormal vasculature characterizes the microenvironment that fuels cancer progression and induces therapeutic resistance in malignant solid tumors (1-3). Glioblastoma multiforme (GBM), the grade IV glioma, is among the [...]

Published
2016
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137. User Action Based Adaptive Learning with Weighted Bayesian Classification for Filtering Spam Mail

Author

Kim, Hyun-Jun, Shrestha, Jenu, Kim, Heung-Nam, Jo, Geun-Sik, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Sattar, Abdul, editor, and Kang, Byeong-ho, editor

Published
2006
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143. On Enhancing the Performance of Spam Mail Filtering System Using Semantic Enrichment

Author

Kim, Hyun-Jun, Kim, Heung-Nam, Jung, Jason J., Jo, Geun-Sik, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Webb, Geoffrey I., editor, and Yu, Xinghuo, editor

Published
2005
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