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112. Combination of bisacodyl suppository and 1 L polyethylene glycol plus ascorbic acid is a non‐inferior and comfortable regimen compared to 2 L polyethylene glycol plus ascorbic acid.

Author

Kim, Sun Hwa, Kim, Eun Ran, Kim, Kyunga, Kim, Tae Jun, Hong, Sung Noh, Chang, Dong Kyung, and Kim, Young‐Ho

Subjects
*POLYETHYLENE glycol, *VITAMIN C, *SUPPOSITORIES, *PATIENT compliance, *ABDOMINAL pain, *POSTOPERATIVE pain
Abstract

Background and Aim: Appropriate bowel cleansing before colonoscopy is an important factor in increasing the detection rate of lesions. Low‐volume polyethylene glycol (PEG) plus ascorbic acid (PEG‐Asc) reduces the dosage of bowel preparation agent, but still presents discomfort to patients. The primary aim of the present study was to compare the efficacy of bowel cleansing between 2 L PEG‐Asc (control) and 1 L PEG‐Asc with bisacodyl suppository (suppository) groups, and the secondary aim was to investigate complications and tolerability between the two groups. Methods: This was a single‐center prospective randomized controlled study. We identified 168 patients scheduled for colonoscopy between August 2017 and January 2018 and randomly assigned them to the control or to the suppository groups. Efficacy of bowel cleansing was assessed using the Boston Bowel Preparation Scale (BBPS), and side‐effects were surveyed using questionnaires. Results: No significant difference was detected in baseline characteristics including insertion and withdrawal times, and adenoma detection rates between the two groups. Total BBPS score was 7.93 ± 1.06 and 7.74 ± 1.02 in the control and suppository groups, respectively (P = 0.22). Incidence of abdominal pain and nausea was not statistically different, whereas that of sleep disturbance and anal discomfort was higher in the control group. (P = 0.00). Conclusions: One liter PEG‐Asc with bisacodyl suppository resulted in an equivalent bowel‐cleansing outcome with reduced patient discomfort compared to 2 L PEG‐Asc. Therefore, PEG‐Asc with bisacodyl suppository represents a potential alternative and increases patient compliance with bowel preparation. [ABSTRACT FROM AUTHOR]

Published
2020
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123. Long-Term Outcome and Prognostic Factors of Sporadic Colorectal Cancer in Young Patients

Author

Kim, Tae Jun, Kim, Eun Ran, Hong, Sung Noh, Chang, Dong Kyung, and Kim, Young-Ho

Subjects
Adult, Male, Time Factors, Age Factors, Observational Study, Neoplasms, Second Primary, Middle Aged, Prognosis, Disease-Free Survival, Sex Factors, Treatment Outcome, Risk Factors, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Humans, Female, Microsatellite Instability, Neoplasm Recurrence, Local, Colorectal Neoplasms, Early Detection of Cancer, Research Article, Aged, Neoplasm Staging, Proportional Hazards Models, Retrospective Studies
Abstract

Supplemental Digital Content is available in the text, The prognosis of early-onset sporadic colorectal cancer (CRC) patients remains controversial. The objective of this study was to assess the long-term outcome and prognostic factors of sporadic CRC in young patients. From 2006 to 2011, 8207 patients underwent curative or palliative surgery for CRCs in our institution. A total of 693 patients who were ≤45 years old with sporadic CRC were enrolled as the young group. A total of 1823 patients aged between 56 and 65 years were identified as middle-aged control group for this study. Survival outcome and prognostic factors were compared between the two groups. Young patients had higher recurrence rate than older patients in stages I and II (8.8% vs 2.7%, P

Published
2016

124. Long-term PGC1β overexpression leads to apoptosis, autophagy and muscle wasting

Author

Sopariwala, Danesh H., primary, Yadav, Vikas, additional, Badin, Pierre-Marie, additional, Likhite, Neah, additional, Sheth, Megha, additional, Lorca, Sabina, additional, Vila, Isabelle K., additional, Kim, Eun Ran, additional, Tong, Qingchun, additional, Song, Min Sup, additional, Rodney, George G., additional, and Narkar, Vihang A., additional

Published
2017
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126. Red blood cell β-adrenergic receptors contribute to diet-induced energy expenditure by increasing O2 supply

Author

Kim, Eun Ran, primary, Fan, Shengjie, additional, Akhmedov, Dmitry, additional, Sun, Kaiqi, additional, Lim, Hoyong, additional, O’Brien, William, additional, Xu, Yuanzhong, additional, Mangieri, Leandra R., additional, Zhu, Yaming, additional, Lee, Cheng-Chi, additional, Chung, Yeonseok, additional, Xia, Yang, additional, Xu, Yong, additional, Li, Feng, additional, Sun, Kai, additional, Berdeaux, Rebecca, additional, and Tong, Qingchun, additional

Published
2017
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131. Survival Outcome and Risk of Metachronous Colorectal Cancer After Surgery in Lynch Syndrome

Author

Kim, Tae Jun, primary, Kim, Eun Ran, additional, Hong, Sung Noh, additional, Kim, Young-Ho, additional, Huh, Jung Wook, additional, Park, Yoon Ah, additional, Cho, Yong Beom, additional, Yun, Seong Hyeon, additional, Kim, Hee Cheol, additional, Lee, Woo Yong, additional, Kim, Kiyoun, additional, Kim, Kyunga, additional, and Chang, Dong Kyung, additional

Published
2016
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134. CD1d Modulates Colonic Inflammation in NOD2−/− Mice by Altering the Intestinal Microbial Composition Comprising Acetatifactor muris.

Author

Lee, Chansu, Hong, Sung Noh, Paik, Nam Young, Kim, Tae Jun, Kim, Eun Ran, Chang, Dong Kyung, and Kim, Young-Ho

Abstract

Aims NOD2 and CD1d play a key role in innate immunity by recognizing conserved molecular patterns of pathogens. While NOD2−/− and CD1d−/− mice display structural and functional alterations in Paneth cells, animal studies have reported no impact of NOD2 or CD1d deficiency on experimental colitis. NOD2 mutations increase the susceptibility to inflammatory bowel diseases and the CD1d bound to α-galactosylceramide [α-GalCer] alleviates intestinal inflammation. We evaluated the effect of CD1d modulation on experimental colitis in NOD2−/− mice. Methods The effect of CD1d augmentation and depletion in NOD2−/− mice was assessed in a dextran sodium sulphate [DSS]-induced colitis model via administration of α-GalCer and construction of NOD2−/−CD1d−/− mice. The structural and functional changes in Paneth cells were evaluated using transmission electron microscopy and pilocarpine administration. Colitogenic taxa were analysed in the faeces of NOD2−/−CD1d−/− mice using 16S rRNA gene sequencing. Results In NOD2−/− mice, α-GalCer alleviated and CD1d depletion [NOD2−/−CD1d−/− mice] aggravated colitis activity and histology compared with co-housed littermates NOD2−/−, CD1d−/− and wild-type mice after administration of 3% DSS. In NOD2−/−CD1d−/− mice, the ultrastructure and degranulation ability of secretary granules in Paneth cells were altered and the intestinal microbial composition differed from that of their littermates. Faecal microbiota transplantation [FMT] with NOD2−/−CD1d−/− mice faeces into wild-type mice aggravated DSS-induced colitis, while FMT with wild-type mice faeces into NOD2−/−CD1d−/− mice alleviated DSS-induced colitis. Acetatifactor muris was identified only in NOD2−/−CD1d−/− mice faeces and the oral gavage of A. muris in wild-type mice aggravated DSS-induced colitis. Conclusion CD1d modulates colonic inflammation in NOD2−/− mice by altering the intestinal microbial composition comprising A. muris. [ABSTRACT FROM AUTHOR]

Published
2019
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135. Comorbid immune‐mediated diseases in inflammatory bowel disease: a nation‐wide population‐based study.

Author

Park, Sung‐Wook, Kim, Tae Jun, Lee, June Young, Kim, Eun Ran, Hong, Sung Noh, Chang, Dong Kyung, Yang, Mi, Kim, Seonwoo, Shin, Myung‐Hee, and Kim, Young‐Ho

Subjects
IMMUNOLOGIC diseases, INFLAMMATORY bowel diseases, POPULATION, ETIOLOGY of diseases, HOMEOSTASIS
Abstract

Summary: Background: Although a higher risk of other immune‐mediated diseases has been reported in inflammatory bowel disease (IBD) patients, the risk factors of immune‐mediated diseases development and the effect of concomitant immune‐mediated diseases on outcomes remain poorly defined. Aim: To determine the risk factors of incident immune‐mediated diseases and the impact of comorbid immune‐mediated diseases on outcomes in IBD. Methods: Using the National Health Insurance claims data for the entire Korean population, we identified 35 581 IBD patients without immune‐mediated diseases and 595 IBD patients with immune‐mediated diseases from 2012 to 2013, and follow‐up until 2016. We selected four controls by age and sex for comparing with cases. Results: A total of 35 581 IBD patients without immune‐mediated diseases and 142 324 matched controls without immune‐mediated diseases were followed from 2014 to 2016 and of these 239 IBD patients and 357 controls developed immune‐mediated disease. The overall immune‐mediated diseases risk was higher in IBD patients (HR, hazard ratio, 2.47; 95% confidence interval, CI, 2.09‐2.91). In a nested case‐control study of the IBD cohort, adult patients aged ≥20 years and frequent hospitalisation ≥1 per year were independent risk factors for incident immune‐mediated diseases, in contrast, 5‐aminosalicylic acid (5‐ASA) use had protective effect (odds ratio, 0.61; 95% CI, 0.41‐0.90) for developing immune‐mediated diseases. In addition, IBD patients with another immune‐mediated disease had an increased risk of needing anti‐TNF‐α agent (HR, 2.40; 95% CI, 2.02‐2.84) and developing acute flare (HR, 1.76; 95% CI, 1.37‐2.26). Conclusions: The incidence of immune‐mediated diseases in IBD patients was higher than that of non‐IBD population. 5‐ASA use may reduce this risk. [ABSTRACT FROM AUTHOR]

Published
2019
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136. Impact of sarcopenia on the risk of advanced colorectal neoplasia.

Author

Hong, Ji Taek, Kim, Tae Jun, Kim, Eun Ran, Hong, Sung Noh, Kim, Young‐Ho, Chang, Dong Kyung, Pyo, Jeung Hui, Ahn, Hyeon Seon, and Sohn, Insuk

Abstract

Background and Aim: Sarcopenia is a pathological condition characterized by the progressive loss of muscle mass and increased amount of visceral fat. Recent evidence has revealed that sarcopenia is associated with certain diseases. However, the impact of sarcopenia on colorectal neoplasia has not been documented clearly. We studied the association between sarcopenia and advanced colorectal neoplasia in a large screening population. Methods: This cross‐sectional study included 14 024 asymptomatic adults who underwent first‐time screening colonoscopy. Sarcopenia (class II) was defined as an appendicular skeletal muscle mass (ASM)/bodyweight (%) value more than two standard deviations below the mean for healthy young adults. ASM was estimated using bioelectrical impedance analysis. Results: In a multivariable model adjusted for age, sex, obesity (body mass index ≥ 25), smoking status, alcohol intake, regular exercise, and family history of colorectal cancer, the odds ratio (OR) for advanced colorectal neoplasia on comparing participants with sarcopenia (class II) to those without sarcopenia (class I + II) was 1.52 (95% confidence interval [CI], 1.23–1.86). Further adjustment for metabolic parameters attenuated this association, but the association was still significant (OR, 1.34; 95% CI, 1.07–1.68). Furthermore, the multivariable (traditional risk factors)‐adjusted OR associated with a 1% decrease on the introduction of ASM/weight% as a continuous variable in regression models was 1.04 (95% CI, 1.01–1.07) for advanced colorectal neoplasia. Conclusions: Our findings indicate that sarcopenia is significantly and progressively associated with the risk of advanced colorectal neoplasia. This association might be explained by metabolic factors that could be potential mediators of the effect of sarcopenia. [ABSTRACT FROM AUTHOR]

Published
2019
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138. Diagnosis of Bleeding Meckel's Diverticulum in Adults

Author

Hong, Sung Noh, primary, Jang, Hyun Joo, additional, Ye, Byong Duk, additional, Jeon, Seong Ran, additional, Im, Jong Pil, additional, Cha, Jae Myung, additional, Kim, Seong-Eun, additional, Park, Soo Jung, additional, Kim, Eun Ran, additional, and Chang, Dong Kyung, additional

Published
2016
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