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101. Narcoleptic-like Episodes in a Patient Receiving Pegylated Interferon-alpha 2b: A Case Report and Review of Literature.

Author

Lawson BO and Khong HT

Subjects
Adult, DNA Mutational Analysis, HLA Antigens genetics, Humans, Interferon alpha-2, Magnetic Resonance Imaging, Male, Recombinant Proteins adverse effects, Recombinant Proteins therapeutic use, Syncope, Interferon-alpha adverse effects, Interferon-alpha therapeutic use, Melanoma drug therapy, Narcolepsy complications, Polyethylene Glycols adverse effects, Polyethylene Glycols therapeutic use, Skin Neoplasms drug therapy
Abstract

A 26-year-old male developed narcoleptic-like episodes while on pegylated interferon-alpha 2b (peg-IFN-α2b) therapy for stage IIIB melanoma. Once peg-IFN-α2b was discontinued, the narcoleptic-like episodes eradicated. A case report and review of the literature are presented in this article., (Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2017
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102. The Waardenburg syndrome type 4 gene, SOX10, is a novel tumor-associated antigen identified in a patient with a dramatic response to immunotherapy.

Author

Khong HT and Rosenberg SA

Subjects
Antigens, Neoplasm biosynthesis, Antigens, Neoplasm genetics, Clone Cells, DNA, Complementary genetics, DNA-Binding Proteins biosynthesis, DNA-Binding Proteins genetics, Epitopes, T-Lymphocyte immunology, Female, High Mobility Group Proteins biosynthesis, High Mobility Group Proteins genetics, Humans, Immunotherapy, Active, Lymphocytes, Tumor-Infiltrating immunology, Melanoma genetics, Melanoma therapy, Middle Aged, RNA, Messenger biosynthesis, RNA, Messenger genetics, SOXE Transcription Factors, Transcription Factors, Waardenburg Syndrome genetics, Antigens, Neoplasm immunology, DNA-Binding Proteins immunology, High Mobility Group Proteins immunology, Melanoma immunology
Abstract

In this study, we have identified, for the first time, the presence of de novo cellular immune reactivity against the transcription factor SOX10, using tumor-infiltrating lymphocytes obtained from a patient who experienced a dramatic clinical response to immunotherapy. SOX10 acts as a critical transactivator of tyrosinase-related protein-2 during melanoblast development and a potent transactivator of micropthalmia-associated transcription factor, which is considered to be a master gene that controls the development and postnatal survival of melanocytes. Mutations in SOX10 result in Waardenburg syndrome type 4. The overlapping epitopes AWISKPPGV and SAWISKPPGV, designated SOX10: 332-340 and SOX10: 331-340, respectively, were recognized by tumor-infiltrating lymphocyte clone M37 in an HLA-A2-restricted fashion.

Published
2002

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