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Thioureas and their derivatives are organosulfur compounds having excellent biological and non-biological applications. These compounds contain S- and N-, which are nucleophilic and allow for establishing inter-and intramolecular hydrogen bonding. These characteristics make thiourea moiety a very important chemosensor to detect various environmental pollutants. This article covers a broad range of thioureas and their derivatives that are used for highly sensitive, selective, and simple fluorimetric (turn-off and turn-on), and colorimetric chemosensors for the detection and determination of different types of anions, such as CN-, AcO-, F-, ClO- and citrate ions, etc., and neutral analytes such as ATP, DCP, and Amlodipine, etc., in biological, environmental, and agriculture samples. Further, the sensing performances of thioureas-based chemosensors have been compared and discussed, which could help the readers for the future design of organic fluorescent and colorimetric sensors to detect anions and neutral analytes. We hope this study will support the new thoughts to design highly efficient, selective, and sensitive chemosensors to detect different analytes in biological, environmental, and agricultural samples. [ABSTRACT FROM AUTHOR]

INTRODUCTION: As the number of older intensive care unit (ICU) survivors grows, there is an urgent need to identify modifiable risk factors for post‐ICU dementia. METHODS: We performed a secondary data analysis of 3144 ICU patients ≥ 50 years of age without a history of dementia or severe mental illness who were screened as part of the Pharmacological Management of Delirium (PMD) study. Delirium was assessed using the Confusion Assessment Method for the ICU. Dementia was identified using International Classification of Diseases Ninth and Tenth revision codes for dementia or prescription of anti‐dementia medication. RESULTS: Average age (standard deviation) was 65.2 ± 9.5 years; 50.4% were female; and 37.3% were Black. Analyses identified stroke (adjusted hazard ratio [HR] 2.49; 95% confidence interval [CI: 1.52, 4.07], P < 0.001), and depression (adjusted HR 3.03; 95% CI [1.80, 5.10], P < 0.001) as post‐ICU risk factors for dementia. DISCUSSION: Future studies will need to examine whether interventions targeting post‐ICU stroke and depression can lower dementia incidence in ICU survivors. Highlights: Risk factors for post–intensive care unit (ICU) dementia were distinct from those of Alzheimer's disease.Cardiovascular risk factors were not associated with dementia in older ICU survivors.Post‐ICU stroke was associated with a higher risk of dementia in older ICU survivors.Post‐ICU depression was associated with a higher risk of dementia in older ICU survivors. [ABSTRACT FROM AUTHOR]

To maintain a green and sustainable environment for human beings, rapid detection of potentially toxic heavy metals like mercury (Hg(II)) has attracted great attention. Recently, sensors have been designed which can selectively detect Hg(II) over other common available cations and give a naked eye or fluorometric response. In the last two decades, the trend is shifting from bulky organic chemosensors toward nanoparticles due to their rapid response, low cost, eco-friendly and easy synthesis. In this review, promising nanoparticles-based sensors for Hg(II) detection are discussed. The nano-sensors are functionalized with nucleotide or other suitable materials which coordinate with Hg(II) ions and give clear color or fluorescence change. The operational mechanisms are discussed focusing on its four basic types. The nanoparticles-based sensors are even able to detect Hg in three different oxidation states (Hg(II), Hg(I) and Hg(0)). Recently, the trend has been shifted from ordinary nanoparticles to magnetic nanoparticles to simultaneously detect and remove Hg(II) ions from environmental samples. Furthermore, the nano-sensors for Hg(II) are compared with each other and with the reported organic chemosensors. [ABSTRACT FROM AUTHOR]

Fresh water is one of the prime necessities of a society; however, its availability is becoming a major concern with the increasing population. There are not enough sources of fresh water at present due to the high rate of population increase. Many regions worldwide face limited access to fresh water. Given economic limitations, there is an urgent need to create and market technologies enabling households to generate their fresh water. In areas with abundant solar energy and proximity to seawater or well-water sources, solar still technology, if developed and commercialized, offers a cost-effective solution for freshwater needs. Thus, the current study is focused on exploring the potential of solar stills for producing fresh water. A single-slope solar still is designed, fabricated and experimentally tested for the production of fresh water. The results of the analysis indicate a maximum production of 2.88 L/day with an energy efficiency of 52.42% and an exergetic efficiency of 7.04%. Overall, the current study reveals significant potential in utilizing solar stills for producing fresh water, which could be increased further if research is conducted on modifying its basic design to increase its productivity. [ABSTRACT FROM AUTHOR]

Delay Tolerant Networks (DTNs) have the major problem of message delay in the network due to a lack of endto-end connectivity between the nodes, especially when the nodes are mobile. The nodes in DTNs have limited buffer storage for storing delayed messages. This instantaneous sharing of data creates a low buffer/shortage problem. Consequently, buffer congestion would occur and there would be no more space available in the buffer for the upcoming messages. To address this problem a buffer management policy is proposed named “A Novel and Proficient Buffer Management Technique (NPBMT) for the Internet of Vehicle-Based DTNs”. NPBMT combines appropriate-size messages with the lowest Time-to-Live (TTL) and then drops a combination of the appropriate messages to accommodate the newly arrived messages. To evaluate the performance of the proposed technique comparison is done with Drop Oldest (DOL), Size Aware Drop (SAD), and Drop Larges (DLA). The proposed technique is implemented in the Opportunistic Network Environment (ONE) simulator. The shortest path mapbased movement model has been used as the movement path model for the nodes with the epidemic routing protocol. From the simulation results, a significant change has been observed in the delivery probability as the proposed policy delivered 380 messages, DOL delivered 186 messages, SAD delivered 190 messages, and DLA delivered only 95 messages. A significant decrease has been observed in the overhead ratio, as the SAD overhead ratio is 324.37, DLA overhead ratio is 266.74, and DOL and NPBMT overhead ratios are 141.89 and 52.85, respectively, which reveals a significant reduction of overhead ratio in NPBMT as compared to existing policies. The network latency average of DOL is 7785.5, DLA is 5898.42, and SAD is 5789.43 whereas the NPBMT latency average is 3909.4. This reveals that the proposed policy keeps the messages for a short time in the network, which reduces the overhead ratio. [ABSTRACT FROM AUTHOR]

Objective: This study aims to compare the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in hypertensive patients. Study Design: Prospective Observational. Setting: Hayatabad Medical Complex Peshawar. Period: December 2022 to May 2023. Material & Methods: Approach was employed to investigate the metabolic impact of these antihypertensive medications. Involving a cohort of 660 hypertensive individuals. Data collection spanned over 12-week duration, with fasting glucose and lipid profiles assessed at baseline and 4, 8, and 12 weeks. Participants were categorized into hydrochlorothiazide and captopril groups, receiving standardized dosages of 25 mg/day and 50 mg/ day, respectively. Fasting blood samples were analyzed for glucose and lipid parameters. Statistical analyses included paired t-tests and subgroup comparisons. Results: Both groups exhibited reductions in fasting glucose and lipid levels; however, these changes were not statistically significant within the 12-week timeframe. Comparison with national and international studies underscores population-specific variations in antihypertensive effects on metabolism. Conclusion: This study provides insights into the metabolic effects of hydrochlorothiazide and captopril among hypertensive patients. While immediate changes were not significant, the study contributes to the body of knowledge and calls for further research with extended follow-up and broader participant cohorts. [ABSTRACT FROM AUTHOR]

Unmanned underwater vehicles (UUVs) have become increasingly popular in recent years due to their use in various applications. The motivations for using UUVs include the exploration of difficult and dangerous underwater environments, military tasks in mine detection, intelligence gathering and surveillance, the inspection of offshore oil and gas infrastructure in the oil and gas industry, scientific research for studying marine life, and the search and rescue of missing persons or submerged airplanes or boats in underwater environments. UUVs offer many advantages in achieving the desired applications with increased safety, efficiency, and cost-effectiveness. However, there are also several challenges associated with their communication, navigation, power requirements, maintenance, and payload limitations. These types of vehicles are also prone to various disturbances caused by currents of the ocean, propulsion systems, and unmolded uncertainties. Practically, it is a challenging task to design a controller that will ensure optimal performance under these conditions. Therefore, the control system design is of prime importance in the overall development of UUVs. Also, the UUV controller receives input from different sensors, and the data from these sensors are used by the controller to perform different tasks. The control systems of UUVs should take into account all uncertainties and make them stable so that all sensors can perform optimally. This paper presents a complete review of different control system design algorithms for UUVs. The basic logic designs of several control system algorithms are also presented. A comparison is made based on reliability, robustness, precession, and the ability of the controller to handle the nonlinearity that is faced by UUVs during their missions. Simulation and experimental results are thoroughly studied to gain insight into each algorithm. The advantages and disadvantages of each algorithm are also presented, which will facilitate the selection of a suitable algorithm for the control system design of UUVs. [ABSTRACT FROM AUTHOR]

Objective: To investigate the processes that make people with panic disorder more vulnerable to the anxiety brought on by exposure to carbon monoxide. Study Design: Randomized, Cross-over Design. Setting: Hayatabad Medical Complex and Khyber Girls Medical College. Period: April 2022 to December 2022. Material & Methods: Patients with anxietyrelated conditions and volunteers in good health who underwent CO2 testing were included in the research. Various gas mixtures, including air, 5% CO2, and 7.5% CO2, were administered to participants in a random order. Behavioral measures, physiological parameters, and biochemical markers were assessed during and after CO2 inhalation. Results: Panic episodes were elicited in both patients with panic disorder and healthy controls by inhaling 5% CO2. Panic disorder patients experienced significantly higher anxiety, nervousness, dread, and sadness levels during 5% CO2 inhalation compared to healthy subjects. Physiological effects, such as increased pulse rate, contrasted those with panic disorder with those without it. No significant changes were seen in either group as a result of inhaling CO2 with respect to bloodstream levels of "free 3-methoxy-4-hydroxyphenylglycol, cortisol, growth hormone, or prolactin". Conclusion: The inhaling of CO2 may trigger panic episodes and cause more intense behavioral and physicological reactions in those with panic disorder. [ABSTRACT FROM AUTHOR]