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Funding Acknowledgements Type of funding sources: None. Background and aims Myocardial injury is commonly encountered among severely-ill COVID-19 patients. Underlying mechanisms, however, remain incompletely understood. Describing cardiovascular imaging (CVI) abnormalities in this population will provide additional insight into mechanisms of myocardial injury with COVID-19 and may potentially guide management for these patients. Therefore, we aimed to describe CVI abnormalities in COVID-19 patients with elevated high-sensitivity cardiac troponin (hs-cTn). Methods Consecutive hospitalized COVID-19 patients (n = 694) between February and July 2020 were retrospectively identified, including 409 patients with available hs-cTn (≥14 ng/dL was considered abnormal) Abnormality with any CVI—including transthoracic echocardiography (TTE), cardiac CT angiography, cardiac MR or invasive coronary angiography (ICA)—were identified through review of electronic records. Results Hospitalized COVID-19 patients with abnormal hs-cTn (107/409; 26.2%) had more frequent utilization of CVI compared with those with normal hs-cTn (61.7% vs. 30.5%, OR:3.7, 95%CI [2.3,5.8]) or those without available hs-cTn data (61.7% vs. 29.9%, OR:3.8, 95%CI [2.4,6]). Most utilized CVI modalities were TTE (63/107; 58.9%) followed by ICA (6/107; 5.6%). Echocardiographic abnormalities detected include right or left ventricular systolic dysfunction (22%), pericardial effusion (11%), while coronary artery disease was identified in 83.3% of patients who underwent ICA. Conclusion In this single center experience, cardiac biomarker elevation in hospitalized COVID-19 patients was associated with a 3-fold increase in the likelihood of CVI utilization, most commonly TTE. Ventricular systolic dysfunction and severe coronary artery disease were commonly encountered in patients with abnormal hs-cTn. However, these results need to be interpreted in the context of inconsistent use of CVI in patients with elevated cardiac biomarkers, which may preclude arrival at definitive conclusions. Prospective studies with standardized use of CVI in high-risk COVID-19 patients are warranted to advance our understanding of cardiac toxicity with COVID-19.

The basic Lipkin-Meshkov-Glick model displays a second-order ground-state quantum phase transition and an excited-state quantum phase transition (ESQPT). The inclusion of an anharmonic term in the Hamiltonian implies a second ESQPT of a different nature. We characterize this ESQPT using the mean field limit of the model. The alternative ESQPT, associated with the changes in the boundary of the finite Hilbert space of the system, can be properly described using the order parameter of the ground-state quantum phase transition, the energy gap between adjacent states, the participation ratio, and the quantum fidelity susceptibility., I + D + i Projects - MCIN/AEI PID2019-104002GB-C21 PID2019104002GB-C22 PID2020-114687GB-I00 MCIN/AEI/10.13039/501100011033, Junta de Andalucia, European Commission UHU-1262561 US-1380840, Junta de Andalucia P20_01247, ERDF-A Way of Making Europe European Commission, Spanish Government UNHU-15CE-2848, European Union NextGenerationEU/PRTR

Introduction Both surgical and transcatheter aortic valve replacement are effective interventions for treatment of patients with severe aortic stenosis. Data from landmark randomized trials have shown comparable improvement in aortic valve hemodynamics and left ventricular remodeling. Whether similar patterns will be observed in real-world practice has not been completely investigated. Purpose To compare the impact of transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) on short- and intermediate-term changes in aortic valve hemodynamics and left ventricular reverse-remodeling. Methods A total of 213 patients with severe AS were referred for TAVR (n=137) or SAVR (n=76) at a single center (August/ 2015-Feb/ 2021). Patient demographics and echocardiographic parameters of aortic valve stenosis severity were collected retrospectively. Changes over-time in aortic valve area, mean gradient, dimensionless index, left ventricular ejection fraction (EF), and ventricular septal thickness were examined using linear mixed models. Results Patients undergoing TAVR were older with higher STS risk scores and a greater burden of comorbidities (Table). Over a median follow-up of 13 months (IQR 4–31), both groups experienced a significant reduction in aortic valve mean gradient (25.7 mmHg with TAVR and 18.8 mmHg with SAVR), with no significant between-group difference (P=0.15). Aortic valve dimensionless index significantly increased in TAVR and SAVR groups (0.23 and 0.13, respectively) and was more pronounced in the TAVR group (P=0.01). Similarly, aortic valve area increased significantly in both groups (0.66 cm2 and 0.42 cm2, respectively) without a significant across-group difference (P=0.07). On the other hand, left ventricular ejection fraction did not change significantly over time (−0.61 and 1.15 EF points, respectively) with no significant between-group difference at 12 months (P=0.06). Ventricular septal thickness was significantly reduced in both groups, with no significant between group difference (P=0.4; Figure). Conclusion In this real-world experience, both TAVR and SAVR were associated with significant improvement in aortic valve hemodynamic parameters and modest reverse left ventricular remodeling. Furthermore, these changes were comparable with both modalities, adding to available evidence from randomized clinical trials on beneficial effects of both TAVR and SAVR. Funding Acknowledgement Type of funding sources: None. Table 1Figure 1

Funding information This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skodowska-Curie grant agreement No 872081 and from the Spanish National Research, Development, and Innovation plan (RDI plan) under the project PID2019-104002GB-C21 (JKR, MC, and FPB) and COOPB20364 (MC) . This work has also been partially supported by the Consejeria de Conocimiento, Investigacion y Universidad, Junta de Andalucia and European Regional Development Fund (ERDF) , refs. SOMM17/6105/UGR (MC and FPB) and UHU-1262561 (JKR and FPB) ., We characterize excited state quantum phase transitions in the two dimensional limit of the vibron model with the quantum fidelity susceptibility, comparing the obtained results with the information provided by the participation ratio. As an application, we locate the eigenstate closest to the barrier to linearity and determine the linear or bent character of the different overtones for particular bending modes of six molecular species. We perform a fit and use the optimized eigenvalues and eigenstates in three cases and make use of recently published results for the other three cases., European Commission 872081, Spanish National Research, Development, and Innovation plan (RDI plan) PID2019-104002GB-C21 COOPB20364, Junta de Andalucia European Commission SOMM17/6105/UGR UHU-1262561

Iron (Fe) toxicity is a major challenge for plant cultivation in acidic waterlogged soil environments, where lowland rice is a major staple food crop. Only few studies have addressed the molecular characterization of excess Fe tolerance in rice, and these highlight different mechanisms for Fe tolerance. Out of 16 lowland rice varieties, we identified a pair of contrasting lines, Fe-tolerant Lachit and -susceptible Hacha. The two lines differed in their physiological and morphological responses to excess Fe, including leaf growth, leaf rolling, reactive oxygen species generation and Fe and metal contents. These responses were likely due to genetic origin as they were mirrored by differential gene expression patterns, obtained through RNA sequencing, and corresponding gene ontology term enrichment in tolerant vs. susceptible lines. Thirty-five genes of the metal homeostasis category, mainly root expressed, showed differential transcriptomic profiles suggestive of an induced tolerance mechanism. Twenty-two out of these 35 metal homeostasis genes were present in selection sweep genomic regions, in breeding signatures, and/or differentiated during rice domestication. These findings suggest that Fe excess tolerance is an important trait in the domestication of lowland rice, and the identified genes may further serve to design the targeted Fe tolerance breeding of rice crops.

We acknowledge useful discussions with José Miguel Arias, Manuel Calixto, Pedro Pérez Fernández, and Lea Santos. This project received funding from the European Union's Horizon 2020 research and innovation program under Marie Skłodowska-Curie Grant Agreement No. 872081 and from Grant No. PID2019-104002GB-C21 funded by MCIN/AEI/ 10.13039/501100011033 and, as appropriate, by ERDF A way of making Europe, by the European Union, or by the European Union NextGenerationEU/PRTR. This work was also partially supported by the Consejería de Transformación Económica, Industria, Conocimiento y Universidades, Junta de Andalucía, and European Regional Development Fund through Grants No. UHU-1262561 (J.K.-R. and F.P.-B.) and No. PY2000764 and by the Ministerio de Ciencia, Innovación y Universidades (Grant No. COOPB20364) (M.C.). Computing resources supporting this work were provided by the CEAFMC and Universidad de Huelva High Performance Computer located at the Campus Universitario el Carmen and funded by FEDER/MINECO Project No. UNHU-15CE-2848., In most cases, excited-state quantum phase transitions can be associated with the existence of critical points (local extrema or saddle points) in a system’s classical limit energy functional. However, an excited-state quantum phase transition might also stem from the lowering of the asymptotic energy of the corresponding energy functional. One such example occurs in the two-dimensional (2D) limit of the vibron model, once an anharmonic term in the form of a quadratic bosonic number operator is added to the Hamiltonian. This case has been studied in the broken-symmetry phase [Pérez-Bernal and Álvarez-Bajo, Phys. Rev. A 81, 050101 (2010)]. In the present work we delve further into the nature of this excited-state quantum phase transition and we characterize it in the symmetric phase of the model, making use of quantities such as the effective frequency, the expected value of the quantum number operator, the participation ratio, the density of states, and the quantum fidelity susceptibility. In addition to this, we extend the usage of the quasilinearity parameter, introduced in molecular physics, to characterize the phases in the spectrum of the anharmonic 2D limit of the vibron model and a practical analysis is included with the characterization of the critical energies for the linear isomers HCN and HNC., CEAFMC, Consejería de Transformación Económica, Industria, Conocimiento y Universidades, Junta de Andalucía, European Union NextGenerationEU/PRTR, MCIN, Universidad de Huelva High Performance Computer, Ministerio de Ciencia, Innovación y Universidades COOPB20364, European Commission, Ministerio de Economía y Competitividad UNHU-15CE-2848, Horizon 2020 872081, PID2019-104002GB-C21, European Regional Development Fund PY2000764, UHU-1262561, Junta de Andalucía, Agencia Estatal de Investigación

Iron (Fe) toxicity is a major challenge for plant cultivation in acidic water-logged soil environments, where lowland rice is a major staple food crop. Only few studies addressed the molecular characterization of excess Fe tolerance in rice, and these highlight different mechanisms for Fe tolerance in the studied varieties.Here, we screened 16 lowland rice varieties for excess Fe stress growth responses to identify contrasting lines, Fe-tolerant Lachit and -susceptible Hacha. Hacha and Lachit differed in their physiological and morphological responses to excess Fe, including leaf growth, leaf rolling, reactive oxygen species generation, Fe and metal contents. These responses were mirrored by differential gene expression patterns, obtained through RNA-sequencing, and corresponding GO term enrichment in tolerant versus susceptible lines. From the comparative transcriptomic profiles between Lachit and Hacha in response to excess Fe stress, individual genes of the category metal homeostasis, mainly root-expressed, may contribute to the tolerance of Lachit. 22 out of these 35 metal homeostasis genes are present in selection sweep genomic regions, in breeding signatures and/or differentiated during rice domestication. These findings will serve to design targeted Fe tolerance breeding of rice crops.Summary statementLowland rice varieties Hacha and Lachit were selected for contrasting abilities to cope with iron excess stress. Morphological and physiological phenotypes were mirrored by molecular transcriptome changes, indicating altered metal homeostasis in the root as an adaptive tolerance mechanism in Lachit.

Additional file 6: Table 6. Distribution of All Adverse Events for All Subjects Treated with CRFA.

Additional file 5: Table 5. EQ-5D-5L Index Score Through 12 Months.

Additional file 3: Table 3. WOMAC Total Normalized Score Through 12 Months.

Introduction Syndromes paraneoplasiques (SPN) : ensemble de manifestations secondaires associes a une neoplasie, independamment de sa localisation primaire ou ses metastases. Consequence d’une production ectopique hormonale aberrante ou reaction auto-immune par la tumeur s’ameliorant avec traitement efficace du cancer sous-jacent ils ne sont pas specifiques mais doivent faire rechercher systematiquement un cancer pulmonaire surtout chez un fumeur, plus frequents dans les cancers pulmonaires a petites cellules (CPC) que dans les cancers pulmonaires non a petites cellules (CPNPC) manifestations variables : endocriniennes, peau, SNC, hematologique, osteoarticulaires, renales leur frequence est de 10 % dans les cancers bronchiques, constituent parfois la seule manifestation attirant l’attention. Methodes Observation de 8 patients colliges entre 2015 et 2019, 3 femmes et 5 hommes. Les patients de sexe masculins etaient fumeurs, aucune patiente n’etait tabagique. Patients totalement asymptomatiques sur le plan respiratoire au moment du diagnostic, ayant beneficie de TDM thoracique dans le cadre d’investigation etiologique de leurs SPN. Resultats Un patient presentait une surdite totale de perception dans le cadre du SPN neurologique de Denny Brown, confirmee par audiometrie et potentiels evoques auditifs, 1 patient avec osteopathie hypertrophiante pneumique de Pierre Marie et Foix (OAT) dedoublement cortical sur scintigraphie osseuse, 1 patiente presentait un syndrome endocrinien de Cushing trois patients avec syndrome nephrotique (glomerulonephrite extra membraneuse), 1 patiente avec dermatopolymyosite dosage des enzymes musculaires positif, 1 patiente presentait un hippocratisme digital isole deux patients sont decedes avant le diagnostic histologique, en raison d’evolution d’insuffisance renale rapidement mortelle parmi les 6 patients restants, 3 patients presentaient un CPC un adenocarcinome (dermatopolymyosie) deux carcinomes epidermoides un seul patient etait operable au moment du diagnostic (OAT) l’evolution de ces SPN fut favorable pour le syndrome de cushing le syndrome nephrotique ameliore chez 1 seul patient, evolue vers une insuffisance renale rapidement letale pour 2 autres. Conclusion Les SPN restent frequents dans le cancer bronchique particulierement CPC dont ils peuvent etre revelateurs d’ou l’interet de rechercher un cancer sous-jacent meme en l’absence de symptomes respiratoires.

Recent works have shown that the spectroscopic access to highly-excited states provides enough information to characterize transition states in isomerization reactions. Here, we show that the transition state of the bond breaking HCN-HNC isomerization reaction can also be achieved with the two-dimensional limit of the algebraic vibron model. We describe the system's bending vibration with the algebraic Hamiltonian and use its classical limit to characterize the transition state. Using either the coherent state formalism or a recently proposed approach by Baraban et al. [ Science 2015 , 350 , 1338], we obtain an accurate description of the isomerization transition state. In addition, we show that the energy level dynamics and the transition state wave function structure indicate that the spectrum in the vicinity of the isomerization saddle point can be understood in terms of the formalism for excited state quantum phase transitions., 16 pages, 1 figure, and two tables. Supplementary Material included. Accepted for publication in The Journal of Physical Chemistry A

It well known that long-lasting hyperglycaemia disrupts neuronal function and leads to neuropathy and other neurodegenerative diseases. The α-ketoglutarate analogue (DMOG) and the caspase-inhibitor “Ac-LETD-CHO are potential neuroprotective molecules. Whether their protections may also extend glucotoxicity-induced neuropathy is not known. Herein, we evaluated the possible cell-protective effects of DMOG and Ac-LETD-CHO against hyperglycaemia-induced reactive oxygen species and apoptosis in ND7/23 neuronal cells. The impact of glucotoxicity on the expression of HIF-1α and a panel of micro-RNAs of significance in hyperglycaemia and apoptosis was also investigated.ND7/23 cells cultured under hyperglycaemic conditions showed decreased cell viability and elevated levels of ROS production in a dose- and time-dependent manner. However, presence DMOG (500 µM) and/or Ac-LETD-CHO (50 µM) counteracted this effect and increase cell viability concomitant with reduction in ROS production, DNA damage and apoptosis. AcLETD-CHO suppressed hyperglycaemia-induced caspase 3 activation in ND7/23 cells. Both DMOG and Ac-LETD-CHO increased HIF-1α expression paralleled with the suppression of miR-126–5p, miR-128–3p and miR-181 expression and upregulation of miR-26b, 106a-5p, 106b-5p, 135a-5p, 135b-5p, 138–5p, 199a-5p, 200a-3p and 200c-3p expression.We demonstrate a mechanistic link for the DMOG and Ac-LETD-CHO protection against hyperglycaemia-induced neuronal dysfunction, DNA damage and apoptosis and thereby propose that pharmacological agents mimicking these effects may represent a promising novel therapy for the hyperglycaemia-induced neuropathy.

Forskning inom friktion idag är mest inriktad på friktion mellan metaller samt friktion mellan metaller och andra material. Friktion mellan träytor förekommer i en begränsad omfattning och tas sällan upp. I byggsammanhang och på många andra områden behöver kunskapen om friktion ökas och tillförlitligheten hos antagna friktionskoefficienter behöver förbättras. En bestämning av statiska friktionskoefficienter mellan träytor parallellt fiberriktningen har gjorts för LVL av barrträ, respektive LVL av bok. Bestämningen av friktionskoefficienter gjordes genom experimenten med hjälp av ett lutande plan. En jämförelse av de statiska friktionskoefficienterna visar att en råare yta och en lägre densitet ger en högre friktionskoefficient.

We thank useful discussion with Profs. Francesco Iachello, Renato Lemus, and Georg Mellau. This project has received fund-ing from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 872081 and from the Spanish National Research, Development, and Innovation plan (RDI plan) under the project PID2019-104002GB-C21. This work has also been partially supported by the Consejeria de Conocimiento, Investigacion y Universidad, Junta de Andalucia and European Regional Development Fund (ERDF), ref. SOMM17/6105/UGR, by the Ministerio de Ciencia, Innovacion y Universidades (ref.COOPB20364), and by the Centro de Estudios Avanzados en Fisica, Matematicas y Computacion (CEAFMC) of the University of Huelva. JKR thanks support from the Youth Employment Initiative and the Youth Guarantee program supported by the European Social Fund. FPB and JKR thank the obtained support from the project UHU-1262561. Computing resources supporting this work were provided by the CEAFMC and Universidad de Huelva High Performance Computer (HPC@UHU) located in the Campus Universitario El Carmen and funded by FEDER/MINECO project UNHU-15CE-2848., We present an extension of the Hamiltonian of the two dimensional limit of the vibron model to encompass all possible interactions up to four-body operators. We apply this Hamiltonian to the modeling of the bending spectrum of four molecules: HNC, H2S, Si2C, and NCNCS. The selected molecular species include linear, bent, and nonrigid equilibrium structures, proving the versatility of the algebraic approach which allows for the consideration of utterly different physical cases within a single Hamiltonian and a general formalism. For each case we compute predicted bending energies and wave functions, that we use to depict the associated quantum monodromy diagram, Birge-Sponer plot, and participation ratio. In nonrigid cases, we also show the bending energy functional obtained using the coherent -or intrinsicstate formalism., European Commission 872081, Spanish National Research, Development, and Innovation plan (RDI plan) PID2019-104002GB-C21, Junta de Andalucia, European Commission SOMM17/6105/UGR, Ministerio de Ciencia, Innovacion y Universidades COOPB20364, Centro de Estudios Avanzados en Fisica, Matematicas y Computacion (CEAFMC) of the University of Huelva, European Social Fund (ESF), FEDER/MINECO UNHU-15CE-2848, UHU-1262561

Introduction La sangsue peut etre le corps etranger laryngo-tracheobronchique le plus redoutable car elle peut passer inapercus et generer des symptomes respiratoires dramatiques. Sa suspicion est essentiellement liee a la consommation de l’eau de source et sa confirmation necessite absolument une exploration endoscopique. Methodes L’etude concerne 4 patients, 3 hommes et une femme, âges en moyenne de 48,5 ans tous de l’Ouest algerien ayant presente des symptomes respiratoires severes dues a l’inhalation de sangsues. Les ANCD etaient sans particularite chez tous les patients, les symptomes etaient marques par l’hemoptysie abondante 3 cas et la dyspnee aigue paroxystique en 2 temps 1 cas, la SPO2 etait a plus de 93 % pour l’ensemble des patients, un examen ORL avec nasofibroscopie sans particularite dans les 4 cas, un telethorax normal pour l’ensemble des patients. La notion de consommation d’eau de source etait retrouvee chez les 4 patients, le delai moyen entre la consommation et le debut des symptomes est de 3 jours, la bronchoscopie souple confirme le dg et le siege de sangsue (mobile entre les cordes vocales 1 cas, au niveau de l’hypopharynx accrochee a la muqueuse 1 cas, endobronchique droit 1 cas, endobronchique gauche un cas). L’extraction etait faite a laide de la pince a biopsie avec succes conduisant a l’amelioration des symptomes chez l’ensemble des patients. Conclusion L’inhalation de sangsue reste frequente en milieu rural, elle peut passer inapercus et engendrer des symptomes respiratoires pouvant aller de la dysphonie, la dyspnee a des symptomes plus dramatiques. Il faut en penser encas de notion de baignade ou de consommation d’eau non traitee. La bronchoscopie reste l’examen de choix permettant la localisation et l’extraction.

Introduction Le role des agents infectieux dans la genese des pathologies auto-immunes est bien etabli, dont les mycobacteries et particulierement le Mycobacterium tuberculosis avec presence d’auto-anticorps la cirrhose biliaire primitive (CBP) est une cholangite auto-immune souvent observee avec la tuberculose cette etude vise a poser une double problematique : etiopathogenique : le M . tuberculosis est-il responsable de la genese de la CBP ou la CBP, pathologie dysimmunitaire favoriserait-elle une reactivation tuberculeuse ? Therapeutique : l’atteinte hepatique potentialise le risque de cytolyse par les antituberculeux et l’arret des immuno-suppresseurs influence defavorablement la CBP. Methodes Etude retrospective sur 5 patientes colligees entre 2011 et 2018 le diagnostic de certitude de tuberculose sur microscopie positive et histologie de biopsie pleurale CBP retenu sur anticorps anti-mitochondries positifs, biopsies hepatiques, serologies virales B et C negatives. Resultats Toutes les patientes etaient des femmes avec moyenne d’âge de 26 ans 4 patientes presentaient une tuberculose pulmonaire a microscopie (+) 1 patiente presentait une tuberculose pleurale 3 patientes presentaient une CBP connue et ont developpe une tuberculose la CBP a ete decouverte chez les 2 autres devant la perturbation spontanee du bilan hepatique pretherapeutique avec AC antimitochondries M2 (+) l’atteinte tuberculeuse etait severe avec 1 miliaire et tuberculose extensive multicavitaire et alteration de l’etat general la corticotherapie a ete arretee jusqu’a la fin du traitement le regime de traitement antituberculeux adopte avec Rifampicine et Isoniazide dose minimale il ne fut pas observe d’hepatotoxicite sous ce regime particulier l’evolution de la CBP fut defavorable a l’arret des corticoides chez 2 patientes. Conclusion La tuberculose et la cirrhose biliaire primitive sont deux granulomatoses dont l’association n’est pas rare suggerant une origine commune du granulome par activation polyclonale des lymphocytes B par le BK, cependant cette association s’avere problematique sur le plan therapeutique ou le traitement de l’une influence defavorablement l’evolution de l’autre.