266 results on '"Kevin Lo"'
Search Results
102. Osimertinib-induced biventricular cardiomyopathy with abnormal cardiac MRI findings: a case report
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Karishma Patel, Kristie Y. Hsu, Kevin Lou, Krishan Soni, Yoo Jin Lee, Claire K. Mulvey, and Alan H. Baik
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Osimertinib ,Cardio-oncology ,Cardiomyopathy ,Pericardial effusion ,Tamponade ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Osimertinib is a third-generation epidermal growth factor receptor (EGFR) inhibitor that is currently the first-line treatment for metastatic EGFR-mutated non-small-cell lung cancer (NSCLC) due to its favorable efficacy and tolerability profile compared to previous generations of EGFR inhibitors. However, it can cause uncommon, yet serious, cardiovascular adverse effects. Case Presentation We present the case of a 63-year-old man with EGFR-mutated NSCLC treated with osimertinib who developed new-onset non-ischemic cardiomyopathy with biventricular dysfunction and heart failure in the context of an enlarging pericardial effusion. For the first time, we demonstrate cardiac MR imaging findings associated with osimertinib-associated cardiomyopathy, including focal late gadolinium enhancement and myocardial edema. The patient’s biventricular function normalized after initiation of goal-directed medical therapy for heart failure and holding osimertinib. The patient was subsequently started on afatinib, a second-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), without recurrence of cardiomyopathy. Conclusions This case highlights the need to better understand osimertinib-induced cardiotoxicity and strategies to optimize oncologic care in patients who develop severe cardiac toxicities from cancer therapy. It further underlines the importance of specialized multidisciplinary care of cancer patients who develop cardiotoxicities to optimize their oncologic outcomes.
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- 2023
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103. Relationship between built environment, socio-economic factors and carbon emissions from shopping trip in Shenyang City, China
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Meng Guo, Kevin Lo, Jing Li, and Pingyu Zhang
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Car ownership ,business.industry ,020209 energy ,Geography, Planning and Development ,Urban sprawl ,02 engineering and technology ,Agricultural economics ,Transport engineering ,Travel behavior ,Geography ,Greenhouse gas ,Public transport ,Sustainability ,0202 electrical engineering, electronic engineering, information engineering ,General Earth and Planetary Sciences ,TRIPS architecture ,business ,Built environment - Abstract
Promoting active travel behavior and decreasing transport-related carbon dioxide (CO2) emissions have become a priority in many Chinese cities experiencing rapid urban sprawl and greater automobile dependence. However, there are few studies that holistically examine the physical and social factors associated with travel CO2 emissions. Using a survey of 1525 shoppers conducted in Shenyang, China, this study estimated shopping-related travel CO2 emissions and examined how the built environment and individual socioeconomic characteristics contribute to shopping travel behavior and associated CO2 emissions. We found that, firstly, private car trips generate nearly eight times more carbon emissions than shopping trips using public transport, on average. Second, there was significant spatial autocorrelation with CO2 emissions per trip, and the highest carbon emissions were clustered in the inner suburbs and between the first and second circumferential roads. Third, shopping travel CO2 emissions per trip were negatively correlated with several built environment features including population density, the quantity of public transport stations, road density, and shop density. They were also found to be significantly related to the individual socio-economic characteristics of car ownership, employment status, and education level using a multinomial logistic regression model. These empirical findings have important policy implications, assisting in the development of measures that contribute to the sustainability of urban transportation and meet carbon mitigation targets.
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- 2017
104. Spatial patterns of car sales and their socio-economic attributes in China
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Kevin Lo, Wei Song, Chunyan Xie, and Daqian Liu
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050210 logistics & transportation ,Variables ,020209 energy ,media_common.quotation_subject ,Lag ,05 social sciences ,Geography, Planning and Development ,02 engineering and technology ,Regression ,Geography ,Multicollinearity ,Scale (social sciences) ,0502 economics and business ,0202 electrical engineering, electronic engineering, information engineering ,Econometrics ,Spatial ecology ,General Earth and Planetary Sciences ,Economic base analysis ,Marketing ,Spatial dependence ,media_common - Abstract
Using data from the Economic Advisory Center of the State Information Center (SIC), we examined the spatial patterns of car sales in China at the prefectural level in 2012. We first analyzed the spatial distributions of car sales of different kinds of automakers (foreign automakers, Sino-foreign joint automakers, and Chinese automakers), and then identified spatial clusters using the local Moran’s indexes. Location quotient analysis was applied to examine the relative advantage of each type of automaker in the local markets. To explain the variations of car sales across cities, we collected several socioeconomic variables and conducted regression analyses. Further, factor analysis was used to extract independent variables to avoid the problem of multicollinearity. By incorporating a spatial lag or spatial error in the models, we calibrated our spatial regression models to address the spatial dependence problem. The analytical results show that car sales varied significantly across cities in China, and most of the cities with higher car sales were the developed cities. Different automakers exhibit diverse spatial patterns in terms of car sales volume, spatial clusters, and location quotients. The scale and incomes factor were extracted and verified as the two most significant and positive factors that shape the spatial distributions of car sales, and together with the spatial effect, explained most of the variations of car sales across cities.
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- 2017
105. Renewable Energy Development in Hong Kong: Potential, Progress, and Barriers
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Kevin Lo
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Consumption (economics) ,Economic growth ,Renewable Energy, Sustainability and the Environment ,Natural resource economics ,business.industry ,020209 energy ,0211 other engineering and technologies ,Energy Engineering and Power Technology ,021107 urban & regional planning ,02 engineering and technology ,Energy storage ,Renewable energy ,Fuel Technology ,Geography ,Environmental engineering science ,0202 electrical engineering, electronic engineering, information engineering ,Total energy ,Feed-in tariff ,Lagging ,China ,business ,Engineering (miscellaneous) - Abstract
Hong Kong is a Special Administration Region of the People’s Republic of China and one of the most developed cities in the country. Although Hong Kong has good potential solar, wind, and waste-to-energy, the development of renewable energy in the region has been lagging. Renewable energies remain a negligible player in the city’s energy system, contributing to less than 1% of total energy consumption. This article critically reviews the potential and current development of renewable energy in Hong Kong and identifies key barriers. In concluding, this article outlines some considerations that need to be made to advance renewable energy development in Hong Kong.
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- 2017
106. Age-differentiated impact of land appropriation and resettlement on landless farmers: a case study of Xinghua village, China
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Ran Gao, Tiantian Chen, Kevin Lo, Weiming Tong, and Pingyu Zhang
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Social unrest ,Compensation (psychology) ,05 social sciences ,Geography, Planning and Development ,0211 other engineering and technologies ,0507 social and economic geography ,021107 urban & regional planning ,02 engineering and technology ,Livelihood ,Appropriation ,Geography ,Environmental protection ,Urbanization ,Homogeneous group ,China ,Socioeconomics ,050703 geography ,Earth-Surface Processes - Abstract
Land appropriation and subsequent resettlement of rural inhabitants are central to urbanisation in China. Often, the result is the impoverishment of landless farmers, who are a principal source of social unrest in the country. In the literature, landless farmers are often wrongly assumed to be a homogeneous group. In contrast, this paper presents the age-differentiated experiences of land appropriation and resettlement among farmers. Using the case study of Xinghua village in China, and by reference to data collected via surveys and interviews, we show that even within a single community, there can be significant age-related differences in terms of compensation, livelihood changes, income, living conditions, and satisfaction. Older farmers tend to receive more compensation, and the negative impact of land appropriation is felt most acutely by middle-aged farmers. Viewed from a broader theoretical perspective, this study demonstrates the importance of understanding the impact of land appropriation and resettlement and shows how this impact is distributed unevenly across the affected communities.
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- 2017
107. Asian Energy Challenges in the Asian Century
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Kevin Lo
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Sustainable development ,Economic growth ,Download ,Multidisciplinary approach ,Energy (esotericism) ,Political science ,Global warming ,Development economics ,Energy security ,Asian Century ,Digital Commons - Abstract
In this first article in the inaugural issue of the Journal of Asian Energy Studies (JAES), the scene is set for further discussions and debates on the energy challenges in Asia. Energy is fundamental to economic development. Thus far, Asia has been largely meeting its skyrocketing energy demand through conventional technologies based on fossil fuels. However, challenges relating to energy security, local pollution, and global climate change mean that such a path is no longer feasible and Asian countries must meet their growing energy demands in a more sustainable manner. Addressing these challenges is not only critical to the realization of the Asian century, but also to global sustainable development. Multidisciplinary and interdisciplinary energy studies have much to offer in addressing these pressing issues. The mission of JAES is to provide a free and international forum for scholars and professionals working in this exciting and important field of study. DOWNLOAD HISTORY | This article has been downloaded 830 times in Digital Commons before migrating into this platform.
- Published
- 2017
108. SAT-006 Dihydrotestosterone (DHT) Enhances Major Burn Injury Wound Healing by Regulating the Inflammatory Response in Mice
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Mark S. Cooper, Brian Lesmana, Kevin Lo, Brenton Condor, Yiwei Wang, Jonathan J. Hew, Peter K.M. Maitz, Duncan Ma, Ulla Simanainen, David J. Handelsman, Roxanne Parungao, Kevin Tasi, and Huaikai Shi
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business.industry ,Endocrinology, Diabetes and Metabolism ,Dihydrotestosterone ,Inflammatory response ,Medicine ,Major burn ,Steroid Hormone Biology and Action ,Steroid Hormones and Receptors ,Pharmacology ,business ,Wound healing ,medicine.drug - Abstract
Androgen analogy (Oxandrolone) have been reported to better maintain lean body mass, with improved hypermetabolic responses and shortened healing time for major burn injured patients. This is contradictory to that androgens inhibit local wound repair in men and male mice. The aim of this study therefore is to identify the role of pure androgen dihydrotesterone (DHT) in complex major burn injury, in particularly whether androgen targets local healing process or systemic burn induced hypermetabolism. A DHT silastic tube was subcutaneously implanted to male Balb/c mice prior to surgery as the treatment group. A 2 X 2 cm2 full thickness contact burn wound was created on the dorsal skin of wild type littermates (control) or DHT treated mice. Wound healing rate and body weight changes were measured and compared between treatment and non-treatment group. The serum level of inflammatory cytokine/chemokine was measured using a Multiplex Immunoassay System. Spleen immune cells enumeration was analysis by flow cytometry. Inflammation, re-epithelialization, cell proliferation and collagen deposition was analysed using histology, immunohistochemistry and RT-PCR. In the present study, we found DHT treatment better maintained the body weight in mice and significantly promoted wound healing over 14 days, whereas DHT treatment had no effect on burn-induced hypermetabolism. In control group, major burn injury triggered an acute systematic inflammation response, resulting in significant increased weight of spleen, excess infiltration of nucleated erythroid cells in red pulps of spleen and a significant increase in number of splenic monocytes over 21 days. DHT treatment shortened the systemic inflammation response, evidenced via reduced splenic weight and the number of monocytes in spleen and circulation at day 14 and 21. This finding is further confirmed by less infiltration of macrophages in wound area at day 14 and 21 compared to control group. Taken together, our results suggesting the DHT treatment significantly improve wound healing by accelerated turnover of inflammation response but not through the metabolism. Further studies are necessary to define the exact mechanisms and DHT treatment could be a new therapeutic approach to improve the survivability of major burn injured patient.
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- 2019
109. Analgesic Use Among Adults with a Trauma-Related Emergency Department Visit: A Retrospective Cohort Study from Alberta, Canada
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Bill Sevcik, Kevin Lobay, Huong Luu, Karen J. B. Martins, Khanh Vu, Phuong Uyen Nguyen, Solmaz Bohlouli, Dean T. Eurich, Erica L. W. Lester, Tyler Williamson, Lawrence Richer, and Scott W. Klarenbach
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Administrative data ,Analgesia ,Emergency department ,Retrospective ,Anesthesiology ,RD78.3-87.3 - Abstract
Abstract Introduction A better understanding of current acute pain-driven analgesic practices within the emergency department (ED) and upon discharge will provide foundational information in this area, as few studies have been conducted in Canada. Methods Administrative data were used to identify adults with a trauma-related ED visit in the Edmonton area in 2017/2018. Characteristics of the ED visit included time from initial contact to analgesic administration, type of analgesics dispensed during and upon being discharged home directly from the ED (≤ 7 days after), and patient characteristics. Results A total of 50,950 ED visits by 40,505 adults with trauma were included. Analgesics were administered in 24.2% of visits, of which non-opioids were dispensed in 77.0% and opioids were dispensed in 49.0%. Time to analgesic initiation occurred more than 2 h after first contact. Upon discharge, 11.5% received a non-opioid and 15.2% received an opioid analgesic, among whom 18.5% received a daily dose ≥ 50 morphine milligram equivalents (MME) and 30.2% received > 7 days of supply. Three hundred and seventeen adults newly met criteria for chronic opioid use after the ED visit, among whom 43.5% received an opioid dispensation upon discharge; of these individuals, 26.8% had a daily dose ≥ 50 MME and 65.9% received > 7 days of supply. Conclusions Findings can be used to inform optimization of analgesic pharmacotherapy practices for the treatment of acute pain, which may include reducing the time to initiation of analgesics in the ED, as well as close consideration of recommendations for acute pain management upon discharge to provide ideal patient-centered, evidence-informed care.
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- 2023
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110. A Process Map of NGS for FIGG
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Sara Walker and Kevin Lord
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Criminal law and procedure ,K5000-5582 - Published
- 2024
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111. Exploring the causes underlying the latitudinal variation in range sizes: Evidence for Rapoport's rule in spiny lizards (genus Sceloporus).
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Kevin López-Reyes, Carlos Yáñez-Arenas, and Fabricio Villalobos
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Medicine ,Science - Abstract
Species' range size is a fundamental unit of analysis in biodiversity research, given its association with extinction risk and species richness. One of its most notable patterns is its positive relationship with latitude, which has been considered an ecogeographical rule called Rapoport's rule. Despite this rule being confirmed for various taxonomic groups, its validity has been widely discussed and several taxa still lack a formal assessment. Different hypotheses have been proposed to explain their potential mechanisms, with those related to temperature and elevational being the most supported thus far. In this study, we employed two level of analyses (cross-species and assemblage) to investigate the validity of Rapoport's rule in spiny lizards (genus Sceloporus). Additionally, we evaluated four environmental-related hypotheses (minimum temperature, temperature variability, temperature stability since the last glacial maximum, and elevation) posed to explain such pattern, contrasting our results to those patterns expected under a null model of range position. Our results provided support for Rapoport's rule at both levels of analyses, contrasting with null expectations. Consistently, minimum temperature and elevation were the most relevant variables explaining the spatial variation in range size. At the cross-species level, our null simulations revealed that both variables deviated significantly from random expectations. Conversely, at the assemblage level, none of the variables were statistically different from the expected relationships. We discussed the implication of our findings in relation to the ecology and evolution of spiny lizards.
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- 2024
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112. Spatial restructuring through poverty alleviation resettlement in rural China
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Mark Wang, Longyi Xue, and Kevin Lo
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Economic growth ,Government ,Sociology and Political Science ,Poverty ,Restructuring ,Geography, Planning and Development ,0211 other engineering and technologies ,Land consolidation ,021107 urban & regional planning ,02 engineering and technology ,010501 environmental sciences ,Development ,Standard of living ,Livelihood ,01 natural sciences ,Urbanization ,China ,0105 earth and related environmental sciences - Abstract
Poverty alleviation resettlement (PAR) is one of China’s key poverty reduction initiatives. Through this state-led resettlement programme, the government aims to improve the living standards and access to infrastructure and services of the rural poor. This paper examines PAR from the perspective of spatial restructuring through a household survey conducted in Shanxi and Shaanxi provinces. A total of 30 resettlement sites were examined. The results show that PAR has two spatial forms: long-distance resettlement, which resettles people to cities or towns, and short-distance resettlement, which resettles people within the administrative boundaries of their village or to a nearby village. Furthermore, the type of spatial restructuring is an important factor shaping the outcome of resettlement. While long-distance resettlement outperforms short-distance resettlement in terms of gains in income, the advantage is offset by higher post-resettlement expenses. Furthermore, long-distance resettlers face a greater challenge in securing non-agricultural employment. Consequently, the level of satisfaction is lower among long-distance resettlers. Significant challenges remain to be addressed for both types of resettlement, including establishing two-way communication between villagers and the government about resettlement plans and providing better financial support for the resettlers, safeguards for the livelihoods of non-movers, and post-resettlement support programmes to help resettlers adjust to their new environments.
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- 2016
113. How authoritarian is the environmental governance of China?
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Kevin Lo
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Corporate governance ,Geography, Planning and Development ,Authoritarianism ,Management, Monitoring, Policy and Law ,16. Peace & justice ,7. Clean energy ,Politics ,Environmental governance ,13. Climate action ,Central government ,Political science ,11. Sustainability ,Environmentalism ,National Policy ,Economic system ,China - Abstract
This paper challenges the prevailing perception that the environmental governance of China is a case exemplar of authoritarian environmentalism. Using low-carbon governance as an example, it shows that although China's national low-carbon policy appears highly authoritarian, the situation on the ground is much more ambiguous, displaying a mixture of authoritarian and liberal features. While China's top-down and non-participatory policy environment has been crucial in stimulating a low-carbon transition, the failure of the central government to control local actors has created a situation of de facto neoliberal environmentalism, where local governments and energy-intensive enterprises enjoy a high degree of freedom and flexibility to manage their own energy consumption in spite of the overt authoritarian rule. The findings of this research show that viewing China's environmental governance as a clear-cut instance of authoritarian environmentalism should be done with circumspection, and that studying the nature of environmental governance as a complex process requires a thorough understanding of not just national policy but also local politics and the ways the two are connected.
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- 2015
114. A 0.55THz Y-Vector Network Configured Beam Steering Phased Array in CMOS Technology
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Weikang Qiao, Kevin Zhang, Hsin-Chia Lu, Tzu-Shiuan Tseng, Yan Zhang, Michael Kevin Lo, Mau-Chung Frank Chang, Yan Zhao, Chewn-Pu Jou, and Richard Al Hadi
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0301 basic medicine ,Beamforming ,Physics ,business.industry ,Phased array ,Terahertz radiation ,020208 electrical & electronic engineering ,Beam steering ,Electrical engineering ,02 engineering and technology ,Front and back ends ,03 medical and health sciences ,030104 developmental biology ,CMOS ,0202 electrical engineering, electronic engineering, information engineering ,Insertion loss ,business ,Phase shift module - Abstract
A Y-vector oscillator network is devised to configure (sub)-mm-wave/terahertz (THz) beamforming systems with minimized footprint and energy consumption. It requires no traditional adjustable phase shifter at multi-channel front end which usually suffer from high insertion loss at these frequencies. A compact (1.4mm2) CMOS lx4 Beam Steering Phased Array (BSPA) based on this network is validated at 0.55THz with $\pm \mathbf{30}^{\circ}$ steering angle range. This is the first monolithic BSPA reported beyond 0.5THz.
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- 2018
115. What Influences the Choice Between Private Car and Public Transport for Shopping Trips? Impact of Socio-economic and Built Environment Factors
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Kevin Lo, Meng Guo, and Jing Li
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Sustainable development ,Transport engineering ,Car ownership ,Travel survey ,business.industry ,Public transport ,Per capita ,TRIPS architecture ,business ,Mode choice ,Built environment - Abstract
Shifting toward sustainable daily travel will play a significant role in the future of sustainable development and the lowering of carbon emissions. This study provides an in-depth comparison of transport mode choice and corresponding CO2 emissions between private cars and public transport used for shopping trips based on individual data from a travel survey conducted in Shenyang, China. The analysis found that bus travel accounted for the majority of motorized transportation. Public transport users were closely distributed along the bus or metro lines, and aggregated private car users were mainly clustered within the second circumferential road. Furthermore, average per trip emissions for private car travel were 8-fold that of public transport. Binary logistic regression modeling was employed to examine factors that were related to the choice between private car and public transport, and the results indicated that car ownership and gender were the most important factors in explaining the preference of car driving. Age and per capita monthly income were negatively correlated with car driving. In addition, there were also negative impacts associated to the built environment factors of access to the closest metro stations and the number of bus stops near the residence on car driving. This study is vital to formulate more effective transportation policy measures in the future development for a sustainable low-carbon city. DOWNLOAD HISTORY | This article has been downloaded 775 times in Digital Commons before migrating into this platform.
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- 2018
116. Reducing Carbon Emissions from Shopping Trips: Evidence from China
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Meng Guo, Jing Li, Mark Wang, Kevin Lo, and Pingyu Zhang
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China ,Control and Optimization ,Energy Engineering and Power Technology ,lcsh:Technology ,Agricultural economics ,Limited access ,Transport engineering ,shopping ,Electrical and Electronic Engineering ,travel mode ,Engineering (miscellaneous) ,Consumer behaviour ,Car ownership ,Land use ,Renewable Energy, Sustainability and the Environment ,business.industry ,lcsh:T ,Greenhouse gas ,Public transport ,transport ,TRIPS architecture ,Business ,carbon emissions ,urban ,Energy (miscellaneous) - Abstract
With rising income and the emergence of modern shopping centers in urban China, shopping trips by private car becomes more and more common, leading to higher carbon emissions in the transport sector. Encouraging car owners to shift transport mode from private car to public transport could achieve significant emissions reductions. This study estimate carbon emissions savings by shifting from private cars to public transport for shopping trips in urban China, using Shenyang, one of the largest cities in China, as a case study. Our results show that the average carbon emissions per shopper is 426.9 g, and the carbon emissions on weekends is 13% higher than weekdays. Moreover, shoppers travelling by private car emitted five times more carbon emission than those by public transport. We also found that car ownership gradually increased as accessibility to public transport decreased, and that more car owners chose to travel by private cars than public transport in areas with limited access. This study, thus, highlights the potential for high-quality public transport to reduce the transport sector’s carbon emissions in urban China.
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- 2015
117. Energy conservation in China’s energy-intensive enterprises: An empirical study of the Ten-Thousand Enterprises Program
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Mark Wang, Kevin Lo, and He Li
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Economic growth ,Government ,Renewable Energy, Sustainability and the Environment ,Geography, Planning and Development ,Management, Monitoring, Policy and Law ,7. Clean energy ,Energy conservation ,Climate change mitigation ,Incentive ,Empirical research ,Local government ,Central government ,Business ,Industrial organization ,Efficient energy use - Abstract
The Ten-Thousand Enterprises Program is China’s keystone energy conservation and climate change program. The program has effectively created a class of energy-intensive enterprises that are regulated by the government for energy conservation purposes. Through an empirical study conducted in Changchun, this paper shows that the adoption of energy efficiency technologies and practices has been highly uneven in this class of enterprises because of two reasons. First, a de facto two-tier regulatory system has emerged within the framework of the Ten-Thousand Enterprises Program. Central state-owned enterprises are closely regulated by the State-Owned Assets Supervision and Administration Commission (SASAC) which is a central government apparatus, whereas local state-owned enterprises and privately owned enterprises are regulated by the local government, which has fewer resources and incentives to implement the program rigorously. Second, the Ten-Thousand Enterprises Program bundles together different types of enterprises. This approach places smaller enterprises at a disadvantage and limits their ability to conserve energy.
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- 2015
118. Economic transformation of mining cities in transition economies: lessons from Daqing, Northeast China
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He Li, Kevin Lo, and Mark Wang
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Economies of agglomeration ,media_common.quotation_subject ,Corporate governance ,Geography, Planning and Development ,Planned economy ,Development ,Resource depletion ,ComputingMilieux_GENERAL ,Development studies ,Economy ,Business cycle ,Prosperity ,Business ,Economic system ,Empirical evidence ,media_common - Abstract
All mining cities need to address the problems associated with resource depletion. However, there are crucial differences between mining cities in transition economies and those in market economies. Through a case study from Daqing, which is also known as the oil capital of China, this article sheds light on how mining cities in transition economies transform economically in anticipation of the eventual decline in mining prosperity. With rich empirical evidence gathered through extensive fieldwork, this article argues that mining cities in transition economies are faced not only with problems stemming from the boom-and-bust economic cycles of the dominant mining industry and the inevitable exhaustion of resources, but also with issues associated with the legacy of planned economies. Therefore, the transformation of mining cities in transition economies is often situated in a multi-level governance framework. In contrast, the transformation of mining cities in market economies is mainly a local process in ...
- Published
- 2015
119. The 'Warm Houses' program: Insulating existing buildings through compulsory retrofits
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Kevin Lo
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Finance ,Engineering ,Renewable Energy, Sustainability and the Environment ,business.industry ,media_common.quotation_subject ,Energy Engineering and Power Technology ,Public policy ,Climate change ,Policy analysis ,7. Clean energy ,Civil engineering ,Scarcity ,13. Climate action ,11. Sustainability ,Doors ,business ,China ,Roof ,Stock (geology) ,media_common - Abstract
The importance of insulating the existing building stock in the age of climate change and energy scarcity is well recognized, but effective public policies for doing so have not been forthcoming. This paper analyzes a novel approach pioneered by the city of Changchun in northeast China. Since 2010, the municipal authority has implemented a program to refurbish nearly half a million homes with wall and roof insulation and energy-efficient windows and doors. The success of this program is attributed to an assertive approach and an efficient, government-sponsored funding model. However, the program faces several challenges, including a lack of effective supervision, the negative impact on poor households, and ineffective energy-saving due to a lack of progress in heat-metering reform. This paper concludes by discussing the policy implications of this analysis.
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- 2015
120. Campus sustainability in Chinese higher education institutions
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Kevin Lo
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Government ,Higher education ,business.industry ,media_common.quotation_subject ,Corporate governance ,Face (sociological concept) ,Human Factors and Ergonomics ,Public relations ,Education ,Political science ,Structured interview ,Sustainability ,business ,China ,Welfare ,media_common - Abstract
Purpose – The purpose of this paper is to examine the focuses, motivations and challenges of achieving campus sustainability in Chinese higher education institutions (HEIs). Design/methodology/approach – A multisite case study was conducted in Changchun City, Jilin, where eight HEIs of various types were examined. Structured interviews with school managers, students and government officials were accompanied with analysis of relevant documents. Findings – The focuses of sustainability among the studied HEIs were on water and energy conservation and on non-technical initiatives. The focuses can be explained by motivations and challenges. The HEIs are motivated by government and financial pressures and face challenges in limited accessibility to funding. The reliance of non-technical initiatives has negatively impacted student welfare and has become unpopular among students. Practical implications – The government is advised to increase funding to HEIs in relation to sustainability and to make the funding more equitable. The HEIs are advised to modify sustainability practices that severely affect the daily lives of students, to share the benefits of water and energy conservation with their students and to involve students in sustainability governance. Originality/value – This paper adds to the existing literature in two ways. First, it expands the geographical reach of the literature to developing countries, in general, and to China, in particular. Second, it adopts the multisite case study research approach to study the whole spectrum of Chinese HEIs and highlights the differences among these HEIs when it comes to sustainability.
- Published
- 2015
121. Policy reforms for antibiotic use claims in livestock.
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Price, Lance B., Rogers, Laura, and Kevin Lo
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- 2022
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122. Biomass of Anthonotha macrophylla leaf extract as a mild steel acid corrosion inhibitor: Experimental and theoretical study
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Ifeoma M. Iloamaeke, Sylvester Ezenwa, Lukman Olasunkanmi, Kevin Lobb, and Nnaemeka Nnaji
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Corrosion ,Inhibitor Mild steel ,Anthonotha macrophylla ,Quantum studies ,Technology - Abstract
This study investigated weight loss and electrochemical impedance spectroscopy (EIS) to explore the inhibition potential of Anthonotha macrophylla leaf extract (AME) on mild steel corrosion in 0.5 M H2SO4 medium. The result shows that the highest inhibition efficiency of 90.47 % at 303 K and 80.02 % at 333 K were obtained. At temperatures of 303 K and 333 K, it was discovered that the corrosion rate decreased as the concentration of the AME inhibitor rose from 0.1 g/L (7.73×10−4gcm−2hr−1) to 0.5 g/L (2.27×10−4 gcm−2hr−1). The result of the EIS measurement is in consistent with that of the weight loss method. Adsorption isotherms portrayed that Tempkin and Freundlich's adsorption isotherms were obeyed. Calculated values of Ea, ∆Hads and ∆Gads suggested a physical adsorption mechanism. FTIR, SEM-EDX, and XRD measurements revealed that the AME inhibitor efficiently shields the mild steel surface from further corrosion attack by inducing the formation of passivated film on the mild steel surface. The calculated quantum parameters correlated with experimental results, thus, AME can be used as an alternative inhibitor for the protection of mild steel against corrosion.
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- 2025
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123. P49 Assessing sleep quality and thermal comfort in real bedrooms: towards a standardised methodology
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Iuliana Hartescu, Jaydeep Bhadra, Arash Beizaee, and Kevin Lomas
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Medicine ,Diseases of the respiratory system ,RC705-779 - Published
- 2023
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124. Complement-activating donor-specific anti-HLA antibodies in solid organ transplantation: systematic review, meta-analysis, and critical appraisal
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Solaf Al-Awadhi, Marc Raynaud, Kevin Louis, Antoine Bouquegneau, Jean-Luc Taupin, Olivier Aubert, Alexandre Loupy, and Carmen Lefaucheur
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complement-activation ,donor specific antibodies ,anti-HLA ,rejection ,transplantation outcomes ,Immunologic diseases. Allergy ,RC581-607 - Abstract
IntroductionSeveral studies have investigated the impact of circulating complement-activating anti-human leukocyte antigen donor-specific antibodies (anti-HLA DSAs) on organ transplant outcomes. However, a critical appraisal of these studies and a demonstration of the prognostic value of complement-activating status over anti-HLA DSA mean fluorescence intensity (MFI) level are lacking.MethodsWe conducted a systematic review, meta-analysis and critical appraisal evaluating the role of complement-activating anti-HLA DSAs on allograft outcomes in different solid organ transplants. We included studies through Medline, Cochrane, Scopus, and Embase since inception of databases till May 05, 2023. We evaluated allograft loss as the primary outcome, and allograft rejection as the secondary outcome. We used the Newcastle-Ottawa Scale and funnel plots to assess risk of bias and used bias adjustment methods when appropriate. We performed multiple subgroup analyses to account for sources of heterogeneity and studied the added value of complement assays over anti-HLA DSA MFI level.ResultsIn total, 52 studies were included in the final meta-analysis (11,035 patients). Complement-activating anti-HLA DSAs were associated with an increased risk of allograft loss (HR 2.77; 95% CI 2.33-3.29, p
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- 2023
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125. Cost-Effectiveness of a Hypothetical Gene Therapy for Alzheimer's Disease: A Markov Simulation Analysis
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Thuy Chinh Kieu and Kevin Look
- Subjects
cost effectiveness ,Markov model ,Alzheimer's disease ,gene therapy ,Pharmacy and materia medica ,RS1-441 - Abstract
Background: Alzheimer’s disease is a prevalent neurodegenerative condition causing significant health and economic burden. With limited therapeutic options, clinical trials have been investigating Alzheimer’s disease treatment using more novel approaches, including gene therapy. However, there is limited evidence on the cost-effectiveness of such treatments. Objectives: This research aims to explore the cost-effectiveness of a hypothetical gene therapy for patients with Alzheimer’s disease at varying degrees of severity. Methods: A Markov model with a 20-year time horizon was constructed for simulated cohorts with mild cognitive impairment due to Alzheimer’s disease, assigned to receive either standard of care or a one-time gene therapy administration. Varying costs of care due to disease severity and treatment efficacy were utilized to determine the effect of those variables at different willingness-to-pay thresholds. Results: Under the initial assumption that the hypothetical gene therapy grants a 30% risk reduction in disease progression and entry into institutional care, the maximum cost-effective price for gene therapy is $141,126 per treatment using the threshold of $150,000 per quality-adjusted life year (QALY). By increasing the treatment effectiveness to 50%, cost-effective price nearly doubled at each willingness-to-pay threshold (e.g., $260,902 at the $150,000/QALY threshold). Conclusion: Despite being cost-effective at a very high price, the hypothetical gene therapy for AD would still need to be priced considerably lower than other approved gene therapies on the market. Thus, a comprehensive pharmacoeconomic assessment remains critical in pricing innovative therapy and determining coverage for patients in need.
- Published
- 2023
- Full Text
- View/download PDF
126. A sub-arcsecond pointing stability fine stage for a high altitude balloon platform
- Author
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Robert T. Effinger, Laura Jones-Wilson, Herrick Chang, Aadil Rizvi, Richard Massey, Carson Umsted, Christina Diaz, Paul Clark, Elizabeth Duffy, Joseph Perez, Michael Porter, Hared Ochoa, Carl R. Seubert, Sara Susca, Derek Lewis, Kevin Lo, Kurt Liewer, and Michael Borden
- Subjects
010504 meteorology & atmospheric sciences ,business.industry ,Computer science ,media_common.quotation_subject ,Astrophysics::Instrumentation and Methods for Astrophysics ,Balloon ,01 natural sciences ,Stability (probability) ,law.invention ,Telescope ,Altitude ,Sky ,law ,0103 physical sciences ,Stage (hydrology) ,Aerospace engineering ,business ,010303 astronomy & astrophysics ,0105 earth and related environmental sciences ,media_common ,Remote sensing - Abstract
High-altitude balloons (HABs) are platforms for collecting astrophysical and planetary science data that offer a number of advantages compared to conventional ground-based or space-based systems. However, they also pose a set of new environmental challenges that must be addressed in order to offer a viable alternative to ground-or space-based assets. In particular, maintaining science-quality pointing stability is a critical challenge for HAB platforms. For these missions, dynamic errors must be limited to a fraction of the observation wavelength, so as the wavelength becomes smaller, it becomes more difficult to meet the needed performance. As a result, there are very few existing pointing stabilization solutions that use visible-spectrum guide stars, despite their relatively wide distribution across the sky. This paper describes the results achieved with the STABLE (Sub-arc second Telescope And BaLloon Experiment) project whose goal is to provide the fine pointing stage for a balloon-borne platform observing in the visible wavelength.
- Published
- 2017
127. Grassroots Environmentalism and Low-Carbon Cities
- Author
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Kevin Lo
- Subjects
Grassroots ,Community building ,media_common.quotation_subject ,Political economy ,Political science ,Environmentalism ,Ecovillage ,Psychological resilience ,Environmental planning ,media_common - Abstract
Grassroots environmentalism has emerged as a key driver for low-carbon cities. This chapter describes and analyses three cases of grassroots environmentalism: the transition town movement, the ecovillage movement, and community renewable energy initiatives. It shows that, rather than business-as-usual, advocates of grassroots environmentalism envision a fundamental transformation of everyday practices based on community building, resilience, economic localisation, and dematerialisation.
- Published
- 2017
128. Urban carbon governance and the transition toward low-carbon urbanism: review of a global phenomenon
- Author
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Kevin Lo
- Subjects
Grassroots ,Economic growth ,Field (Bourdieu) ,Corporate governance ,Transition (fiction) ,Phenomenon ,Political science ,Climate change ,Network governance ,Economic geography ,Urbanism ,General Environmental Science - Abstract
This paper reviews the literature on urban carbon governance, which has become a burgeoning area of research. Since the early 1990s, the field has grown and diversified geographically, theoretically and methodologically, and now encompasses a wide range of topics, including governing techniques, limitations and challenges, central-local relations, municipal networks, network governance and grassroots initiatives. Given the increasingly global nature of low-carbon urbanism and governance, these studies have expanded our knowledge on the complexity and plurality of the role of cities in addressing climate change. This review serves as a consolidated guide for researchers, policymakers and students in this field.
- Published
- 2014
129. Urbanization in remote areas: A case study of the Heilongjiang Reclamation Area, Northeast China
- Author
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Kevin Lo, Pingyu Zhang, and Shiwei Liu
- Subjects
Government ,Economic growth ,business.industry ,Economic liberalization ,Livelihood ,Agricultural economics ,Urban Studies ,Geography ,Agriculture ,Urbanization ,Urban climate ,Agrarian system ,China ,business - Abstract
In a remote part of Northeast China, thousands of villages have disappeared from the map. Their inhabitants, more than 600,000 farmers, have been instructed by the government to relocate to nearby towns and commute to their farms to work. By concentrating the dispersed rural population in a small number of urban cores, the government hopes to improve housing conditions and accessibility to services, stimulate economic development, and free up more land for farming. This paper analyzes this kind of urbanization, which is distinct from the much-studied city-centered urbanization and in situ urbanization in coastal China. In addition to the resettlement program, this urbanization process is driven by agricultural modernization and economic liberalization. Urbanization has produced a rural–urban hybrid settlement system where urban construction coexists with a mostly agrarian economy. Urbanization has also improved the livelihood of many rural households, but there are significant social, economic, and environmental challenges.
- Published
- 2014
130. China's low-carbon city initiatives: The implementation gap and the limits of the target responsibility system
- Author
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Kevin Lo
- Subjects
Urban Studies ,Energy conservation ,Government ,Economic growth ,Incentive ,Public economics ,Central government ,Energy intensity ,Control (management) ,Energy consumption ,Energy statistics ,Business - Abstract
The Chinese government has promulgated a wide variety of low-carbon initiatives to control the rapid growth of energy consumption and carbon emissions in the cities. Past records, however, show that the central government's policies are often poorly implemented or distorted by local officials. Using a case study from the city of Changchun, this paper examines how and why the issue of poor implementation persists despite the establishment of the Energy Conservation Target Responsibility System (ECTRS). As a key institutional mechanism providing local officials with political incentives to implement low-carbon policies, the ECTRS has been constrained by a number of problems, including a poorly designed scoring system, weak targets, the use of energy intensity instead of absolute energy consumption as a policy objective, and the lack of reliable local energy statistics.
- Published
- 2014
131. Energy-Related Carbon Emissions of China’s Model Environmental Cities
- Author
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Kevin Lo
- Subjects
Environmental issue ,Geography ,Environmental protection ,Natural resource economics ,Central government ,Greenhouse gas ,Accounting information system ,Per capita ,Climate change ,China - Abstract
This paper identifies three types of model environmental cities in China and examines their levels of energy-related carbon emissions using a bottom-up accounting system. Model environmental cities are identified as those that have been recently awarded official recognition from the central government for their efforts in environmental protection. The findings show that, on average, the Low-Carbon Cities have lower annual carbon emissions, carbon intensities, and per capita emissions than the Eco-Garden Cities and the Environmental Protection Cities. Compared internationally, the Eco-Garden Cities and the Environmental Protection Cities have per capita emissions that are similar to those of American cities whereas per capita emissions from the Low-Carbon Cities are similar to those of European cities. The result indicates that addressing climate change is not a priority for some model environmental cities. Policy changes are needed to prioritize climate mitigation in these cities, considering that climate change is a cross-cutting environmental issue with wide-ranging impact.
- Published
- 2014
132. A critical review of China's rapidly developing renewable energy and energy efficiency policies
- Author
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Kevin Lo
- Subjects
Government ,Renewable Energy, Sustainability and the Environment ,business.industry ,Local government ,Economics ,Energy security ,Environmental economics ,Policy analysis ,Livelihood ,China ,business ,Efficient energy use ,Renewable energy - Abstract
Renewable energy and energy efficiency (REEE) policies have far-reaching implications for energy security, climate change, economic competitiveness, pollution, and human livelihood. For these reasons, REEE has become a national priority for the Chinese government, particularly since 2005. This paper aims to critically review China's REEE policies in six sectors: electricity, industry, transportation, buildings, and local government. In addition to examining the progress China has made in the development and implementation of REEE policies, this review also identifies limitations and room for improvement. Finally, five policy recommendations are presented.
- Published
- 2014
133. Eco-Efficiency Analysis of Industrial Systems in the Songhua River Basin: A Decomposition Model Approach
- Author
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Lianjun Tong, Fuyou Guo, and Kevin Lo
- Subjects
China ,020209 energy ,Songhua River basin ,Geography, Planning and Development ,Midstream ,Resource efficiency ,TJ807-830 ,02 engineering and technology ,010501 environmental sciences ,Management, Monitoring, Policy and Law ,Eco-efficiency ,TD194-195 ,environmental impact ,01 natural sciences ,Renewable energy sources ,0202 electrical engineering, electronic engineering, information engineering ,GE1-350 ,Environmental impact assessment ,0105 earth and related environmental sciences ,Downstream (petroleum industry) ,Upstream (petroleum industry) ,Sustainable development ,Environmental effects of industries and plants ,Renewable Energy, Sustainability and the Environment ,business.industry ,Circular economy ,Environmental resource management ,Environmental engineering ,eco-efficiency ,Environmental sciences ,industrial system ,spatiotemporal difference ,Environmental science ,business - Abstract
Eco-efficiency is an important sustainable development and circular economy construct that conceptualizes the relationship between industrial output, resource utilization, and environmental impacts. This paper conducts an eco-efficiency analysis for basin industrial systems using the decomposition model approach. Using data on 10 cities in China’s Songhua River basin, we illustrate the evolutionary characteristics and influencing factors of industrial systems’ eco-efficiency. The results indicate that cities in upstream and midstream areas focus on improving resource efficiency, whereas cities in downstream areas focus on improving terminal control efficiency. The results also show that the government plays an increasingly important role in promoting eco-efficiency and that significant differences in the influencing factors exist among the upstream area, midstream area, and downstream area. Our results offer deeper insights into the eco-efficiency of industrial systems and give further hints on how policy-making can help achieve sustainable development, balancing between economic activities and environmental protection.
- Published
- 2016
- Full Text
- View/download PDF
134. Estimating Housing Vacancy Rates in Rural China Using Power Consumption Data
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Meng Guo, Jing Li, and Kevin Lo
- Subjects
Geography, Planning and Development ,0211 other engineering and technologies ,TJ807-830 ,02 engineering and technology ,010501 environmental sciences ,Management, Monitoring, Policy and Law ,TD194-195 ,01 natural sciences ,Rural housing ,Renewable energy sources ,Agricultural economics ,Order (exchange) ,Vacancy defect ,GE1-350 ,National level ,China ,power consumption data ,village hollowing ,0105 earth and related environmental sciences ,Environmental effects of industries and plants ,Renewable Energy, Sustainability and the Environment ,021107 urban & regional planning ,Environmental sciences ,Geography ,Power consumption ,Spatial clustering ,rural housing vacancy ,china ,Regional differences - Abstract
Village hollowing is a growing policy problem globally, but accurately estimating housing vacancy rates is difficult and costly. In this study, we piloted the use of power consumption data to estimate the vacancy rate of rural housing. To illustrate the method used, we took power consumption data in 2014 and 2017 in an area of rural China to analyze the change in housing vacancies. Results indicated that the rural vacancy rates were 5.27% and 8.69%, respectively, while underutilization rates were around 10% in 2014 and 2017. Second, there was significant spatial clustering of vacant rural housing, and the hotspots were mainly distributed in western mountainous areas, whereas villages near urban areas had lower vacancy rates. Third, rural vacancies increased from 2014 to 2017. Compared with other methods, our method proved to be accurate, very cost-effective and scalable, and it can offer timely spatial and temporal information that can be used by policymakers to identify areas with significant village hollowing issues. However, there are challenges in setting the right thresholds that take into consideration regional differences. Therefore, there is also a need for more studies in different regions in order to scale up this method to the national level.
- Published
- 2019
135. Energy conservation in China's higher educationinstitutions
- Author
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Kevin Lo
- Subjects
Economic growth ,Government ,Higher education ,business.industry ,media_common.quotation_subject ,Public policy ,Accounting ,Management, Monitoring, Policy and Law ,Investment (macroeconomics) ,Energy conservation ,General Energy ,Economics ,Quality (business) ,China ,business ,Welfare ,media_common - Abstract
This paper analyzes the energy conservation situation in China's higher education institutions (HEIs). A case study was conducted in Changchun, Jilin, where eight HEIs of various types were examined. An analysis of government policies was also performed. The findings indicate that the HEIs have implemented comprehensive non-technical initiatives to conserve electricity, including electricity restrictions and extensions of winter breaks, as well as certain technical initiatives. The HEIs are less enthusiastic in conserving thermal energy due to a lack of financial incentives and resources. Differences between the HEIs are also noted. This paper discusses the role of key players, including administrators, government agencies, networks, students and non-government organizations (NGOs). Challenges to energy conservation are also identified, such as the lack of investment by schools, lack of government funding, quality problems in energy conservation products, inadequate heat metering reform, underperformance of energy service companies (ESCOs), and conflicts between energy conservation and student welfare. Policy recommendations are offered based on the analysis results.
- Published
- 2013
136. Energy conservation in China’s Twelfth Five-Year Plan period: Continuation or paradigm shift?
- Author
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Kevin Lo and Mark Wang
- Subjects
Energy conservation ,Economic growth ,Renewable Energy, Sustainability and the Environment ,Economic policy ,Paradigm shift ,Political science ,Social change ,Heavy industry ,Plan (drawing) ,China ,Policy analysis ,Energy policy - Abstract
The release of the Twelfth Five-Year Guideline for National Economic and Social Development in March 2011 marked the beginning of China’s Twelfth Five-Year Plan (12th FYP) period (2011–2015). Energy conservation continues to be a national priority. Since the release, new energy conservation policies and programs have been announced by many central ministries in accordance with the 12th FYP. Is this the beginning of a new paradigm or merely a continuation of the 11th FYP model? This paper describes and analyzes key changes in energy conservation since 2011, including a more conservative national energy conservation target, a more logical way of breaking down the target, new sectoral targets, the introduction of new programs, and the expansion of existing programs. However, one key problem of the 11th FYP period remains unresolved, namely the inability to shift the economy away from heavy industry.
- Published
- 2013
137. The development and localisation of a foreign gated community in Beijing
- Author
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Kevin Lo and Mark Wang
- Subjects
Sociology and Political Science ,Community building ,Real estate development ,business.industry ,Urban studies ,International community ,Development ,Economic globalization ,Urban Studies ,Globalization ,Economy ,Beijing ,Tourism, Leisure and Hospitality Management ,Political science ,China ,business - Abstract
The emergence of gated communities for foreign residents in large Chinese cities is the result of economic globalisation, local institutional changes, social relations and cultural globalisation. Using a case study performed in Beijing, this paper seeks to analyse the complex dynamics of foreign gated communities through a critical examination of their key actors. The history of the gated community studied here is divided into two phases: development and localisation. During the development phase, the property developer not only attracted foreign residents through building an international community but also lured Hong Kong investors through the promise of soaring rental returns fuelled by strong demand. During the localisation phase, Chinese residents gradually replaced the developer as the project’s key actors. While the Chinese residents were attracted by the idea of international community, their arrival significantly transformed the community. This paper demonstrates how the survival, character and appearance of a foreign gated community was influenced by temporally and geographically dispersed actors who were subjected to a number of economic, social and cultural forces on a global and a local scale.
- Published
- 2013
138. Discursos sobre o Papel do Tradutor-Intérprete Educacional de Libras/Português
- Author
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Kevin Lopes PEREIRA and Ivoni FREITAS-REIS
- Subjects
Intérprete educacional ,Libras ,Educação Inclusiva ,Surdos ,Special aspects of education ,LC8-6691 - Abstract
RESUMO: O tradutor-intérprete educacional de Língua Brasileira de Sinais (Libras)/Português é fundamental em um espaço educacional que busca ser inclusivo a surdos, porém sua função vem sendo debatida frente à pluralidade existente quanto às disciplinas e aos contextos nos quais esses profissionais atuam. Diante disso, este trabalho promove uma discussão a fim de somar a um constructo que, aos poucos, tece uma perspectiva mais clara acerca dos aspectos que caracterizam a prática de um intérprete educacional. Para isso, analisaram-se respostas de 53 intérpretes de diferentes regiões do Brasil, obtidas por meio de um questionário enviado via Google Forms, que indagava sobre qual seria a sua função no âmbito educacional. A partir disso, aplicando o método de análise de conteúdo, identificaram-se quatro categorias que apontavam o intérprete educacional como: colaborador no processo de inclusão, mediador cultural, coformador do discente surdo e mediador linguístico. Compreende-se que, em sua complexidade, a função do intérprete educacional possui alguns desdobramentos que não podem ser ignorados, atribuindo a esses profissionais um lugar de indiferença ou assistencialismo excessivo nos processos de ensino e de aprendizagem. Ao contrário, eles devem participar ativamente, compreendendo o que caracteriza sua função, também a partir do diálogo com a instituição, discente surdo e comunidade surda.
- Published
- 2023
- Full Text
- View/download PDF
139. Co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells attenuates human NK cell-mediated degranulation
- Author
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Arthur A. Cross-Najafi, Kristine Farag, Abdulkadir Isidan, Wei Li, Wenjun Zhang, Zhansong Lin, Julia R. Walsh, Kevin Lopez, Yujin Park, Nancy G. Higgins, David K.C. Cooper, Burcin Ekser, and Ping Li
- Subjects
xenotransplantation ,natural killer cells ,immune tolerance ,immune rejection ,HLA-E ,HLA-G ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Natural killer (NK) cells play an important role in immune rejection in solid organ transplantation. To mitigate human NK cell activation in xenotransplantation, introducing inhibitory ligands on xenografts via genetic engineering of pigs may protect the graft from human NK cell-mediated cytotoxicity and ultimately improve xenograft survival. In this study, non-classical HLA class I molecules HLA-E and HLA-G were introduced in an immortalized porcine liver endothelial cell line with disruption of five genes (GGTA1, CMAH, β4galNT2, SLA-I α chain, and β-2 microglobulin) encoding three major carbohydrate xenoantigens (αGal, Neu5Gc, and Sda) and swine leukocyte antigen class I (SLA-I) molecules. Expression of HLA-E and/or HLA-G on pig cells were confirmed by flow cytometry. Endogenous HLA-G molecules as well as exogenous HLA-G VL9 peptide could dramatically enhance HLA-E expression on transfected pig cells. We found that co-expression of HLA-E and HLA-G on porcine cells led to a significant reduction in human NK cell activation compared to the cells expressing HLA-E or HLA-G alone and the parental cell line. NK cell activation was assessed by analysis of CD107a expression in CD3-CD56+ population gated from human peripheral blood mononuclear cells. CD107a is a sensitive marker of NK cell activation and correlates with NK cell degranulation and cytotoxicity. HLA-E and/or HLA-G on pig cells did not show reactivity to human sera IgG and IgM antibodies. This in vitro study demonstrated that co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells provided a superior inhibition in human xenoreactive NK cells, which may guide further genetic engineering of pigs to prevent human NK cell mediated rejection.
- Published
- 2023
- Full Text
- View/download PDF
140. Fortalecimiento Lingüístico Fonológico Perceptivo a niños con TDAH Mediante el Uso de Realidad Aumentada (RA)
- Author
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Kevin López Díaz, Tomas Sebastian Mayorga Carrera, Milton Patricio Navas Moya, and Lucas Rogerio Garces Guayta
- Subjects
Realidad Aumentada ,Lingüístico ,TDAH ,Fortalecimiento ,Fonológico ,Perceptivo ,Industrial engineering. Management engineering ,T55.4-60.8 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Computer engineering. Computer hardware ,TK7885-7895 - Abstract
En este artículo se presenta un estudio sobre el fortalecimiento lingüístico fonológico perceptivo en niños con Trastorno por Déficit de Atención e Hiperactividad (TDAH) mediante el uso de realidad aumentada (RA), por lo que se busca evaluar la efectividad de la RA en el desarrollo de habilidades lingüísticas y de atención en estos niños. Los resultados indican que la RA puede ser una herramienta efectiva para mejorar la capacidad de los niños con TDAH para procesar información lingüística y mejorar su capacidad de atención. Además, se encontró que la RA es una forma motivadora y atractiva para los niños, lo que contribuye a un aprendizaje más efectivo y duradero. En general, este estudio sugiere que la RA es una herramienta valiosa para el fortalecimiento académico en niños con TDAH.
- Published
- 2023
- Full Text
- View/download PDF
141. Toward Precision Medicine: Exploring the Landscape of Biomarkers in Acute Kidney Injury
- Author
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Nicole Nourie, Rita Ghaleb, Carmen Lefaucheur, and Kevin Louis
- Subjects
acute kidney injury ,biomarkers ,chronic kidney disease ,Microbiology ,QR1-502 - Abstract
Acute kidney injury (AKI) remains a complex challenge with diverse underlying pathological mechanisms and etiologies. Current detection methods predominantly rely on serum creatinine, which exhibits substantial limitations in specificity and poses the issue of late-stage detection of kidney injury. In this review, we propose an up-to-date and comprehensive summary of advancements that identified novel biomarker candidates in blood and urine and ideal criteria for AKI biomarkers such as renal injury specificity, mechanistic insight, prognostic capacity, and affordability. Recently identified biomarkers not only indicate injury location but also offer valuable insights into a range of pathological processes, encompassing reduced glomerular filtration rate, tubular function, inflammation, and adaptive response to injury. The clinical applications of AKI biomarkers are becoming extensive and serving as relevant tools in distinguishing acute tubular necrosis from other acute renal conditions. Also, these biomarkers can offer significant insights into the risk of progression to chronic kidney disease CKD and in the context of kidney transplantation. Integration of these biomarkers into clinical practice has the potential to improve early diagnosis of AKI and revolutionize the design of clinical trials, offering valuable endpoints for therapeutic interventions and enhancing patient care and outcomes.
- Published
- 2024
- Full Text
- View/download PDF
142. Consumer Travel Behaviors and Transport Carbon Emissions: A Comparative Study of Commercial Centers in Shenyang, China
- Author
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Kevin Lo, Meng Guo, Pingyu Zhang, and Jing Li
- Subjects
China ,Control and Optimization ,020209 energy ,Energy Engineering and Power Technology ,02 engineering and technology ,lcsh:Technology ,Agricultural economics ,Transport engineering ,Inner city ,0202 electrical engineering, electronic engineering, information engineering ,Electrical and Electronic Engineering ,Engineering (miscellaneous) ,Renewable Energy, Sustainability and the Environment ,lcsh:T ,Travel behavior ,Shenyang ,Greenhouse gas ,transport carbon emission ,commercial center ,consumer travel behavior ,Environmental science ,TRIPS architecture ,Urban space ,Energy (miscellaneous) - Abstract
Current literature highlights the role of commercial centers in cities in generating shopping trips and transport carbon emissions. However, the influence of the characteristics of commercial centers on consumer travel behavior and transport carbon emissions is not well understood. This study addresses this knowledge gap by examining shopping trips to eight commercial centers in Shenyang, China, and the CO2 emissions of these trips. We found that the locations and types of commercial centers strongly influence CO2 emissions. CO2 emissions per trip to commercial centers in the suburbs of Shenyang were on average 6.94% and 26.92% higher than those to commercial centers in the urban core and the inner city, respectively. CO2 emissions induced by wholesale centers were nearly three times higher than the lowest CO2 emissions of commercial centers in the inner city. These empirical results enhance our understanding of shopping-related transport carbon emissions and highlight the importance of optimizing urban space structure, in particular, the layout of commercial centers.
- Published
- 2016
143. Correction: Osimertinib-induced biventricular cardiomyopathy with abnormal cardiac MRI findings: a case report
- Author
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Karishma Patel, Kristie Y. Hsu, Kevin Lou, Krishan Soni, Yoo Jin Lee, Claire K. Mulvey, and Alan H. Baik
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2023
- Full Text
- View/download PDF
144. Measuring sustainable urbanization in China: a case study of the coastal Liaoning area
- Author
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Kevin Lo, Shiwei Liu, Pingyu Zhang, and Xiaoli Jiang
- Subjects
Sustainable development ,Global and Planetary Change ,Health (social science) ,Ecological footprint ,Sociology and Political Science ,Ecology ,business.industry ,Geography, Planning and Development ,Environmental resource management ,Management, Monitoring, Policy and Law ,Geography ,Urbanization ,Sustainability ,Human Development Index ,Landscape ecology ,China ,business ,Empirical evidence ,Nature and Landscape Conservation - Abstract
The global urbanization process poses a serious challenge to achieving sustainable development. The significance of sustainable urbanization has been increasingly appreciated, yet, very little empirical evidence has been provided for this prospect. In this paper, we use the Human Development Index and the ecological footprint to measure the sustainability of the coastal Liaoning area. We then use the quadrant map approach to determine the relationship between sustainability and urbanization. The results show that the coastal area has made progress in sustainable urbanization in the social dimension. Improvement in the environmental dimension has been dynamic. Our results indicate that sustainable urbanization is a dynamic, multi-dimensional progress that requires regular monitoring and reevaluation. This paper also highlights the importance of choosing more complete indicators for measuring the sustainability of urbanization, as no single model or measurement is sufficient for quantifying the different dimensions of sustainability.
- Published
- 2012
145. Lithium effects on circadian rhythms in fibroblasts and suprachiasmatic nucleus slices from Cry knockout mice
- Author
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David K. Welsh, Kevin Lo, Tanja Diemer, and Takako Noguchi
- Subjects
0301 basic medicine ,medicine.medical_specialty ,endocrine system ,animal structures ,Period (gene) ,Biology ,In Vitro Techniques ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Cryptochrome ,Antimanic Agents ,Internal medicine ,medicine ,Animals ,Circadian rhythm ,Cells, Cultured ,Mice, Knockout ,Suprachiasmatic nucleus ,General Neuroscience ,Period Circadian Proteins ,Fibroblasts ,Circadian Rhythm ,PER2 ,Cryptochromes ,030104 developmental biology ,Endocrinology ,chemistry ,Light effects on circadian rhythm ,Lithium chloride ,Suprachiasmatic Nucleus ,sense organs ,Lithium Chloride ,030217 neurology & neurosurgery - Abstract
Lithium is widely used as a treatment of bipolar disorder, a neuropsychiatric disorder associated with disrupted circadian rhythms. Lithium is known to lengthen period and increase amplitude of circadian rhythms. One possible pathway for these effects involves inhibition of glycogen synthase kinase-3β (GSK-3β), which regulates degradation of CRY2, a canonical clock protein determining circadian period. CRY1 is also known to play important roles in regulating circadian period and phase, although there is no evidence that it is similarly phosphorylated by GSK-3β. In this paper, we tested the hypothesis that lithium affects circadian rhythms through CRYs. We cultured fibroblasts and slices of the suprachiasmatic nucleus (SCN), the master circadian pacemaker of the brain, from Cry1-/-, Cry2-/-, or wild-type (WT) mice bearing the PER2:LUC circadian reporter. Lithium was applied in the culture medium, and circadian rhythms of PER2 expression were measured. In WT and Cry2-/- fibroblasts, 10mM lithium increased PER2 expression and rhythm amplitude but not period, and 1mM lithium did not affect either period or amplitude. In non-rhythmic Cry1-/- fibroblasts, 10mM lithium increased PER2 expression. In SCN slices, 1mM lithium lengthened period ∼1h in all genotypes, but did not affect amplitude except in Cry2-/- SCN. Thus, the amplitude-enhancing effect of lithium in WT fibroblasts was unaffected by Cry2 knockout and occurred in the absence of period-lengthening, whereas the period-lengthening effect of lithium in WT SCN was unaffected by Cry1 or Cry2 knockout and occurred in the absence of rhythm amplification, suggesting that these two effects of lithium on circadian rhythms are independent of CRYs and of each other.
- Published
- 2015
146. Effects of order flow imbalance on short-horizon contrarian strategies in the Australian equity market
- Author
-
Kevin Lo and Richard Coggins
- Subjects
Transaction cost ,Economics and Econometrics ,Financial economics ,Stock exchange ,Institutional investor ,Economics ,Equity (finance) ,Contrarian ,Portfolio ,Profitability index ,Stock market ,Finance - Abstract
We use Lo and MacKinlay's [Lo, A.W., MacKinlay, C., 1990. When are contrarian profits due to stock market overreaction? The Review of Financial Studies 3, 175–205.] contrarian portfolio approach to examine the profitability of short-horizon contrarian strategies in the context of the Australian Stock Exchange. The results show that simple contrarian strategies lead to small but still statistically significant profits when applied to daily and intra-day portfolio formation. However, the profits are not sufficient to cover transaction costs for institutional investors. The source of contrarian profits is also analyzed leading to the conclusion that stock market overreaction is found to be the primary source of contrarian profits. We also examine the relation between the degree of return reversal and order flow activity after abnormal price changes. We find that the degree of return reversal is positively related to the level of order flow imbalance. Larger profits are generated from order flow based contrarian strategies when the order flow imbalances are high.
- Published
- 2006
147. Micro-credentials in leveraging emergency remote teaching: the relationship between novice users’ insights and identity in Malaysia
- Author
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Jeya Amantha Kumar, Rachel Jasmine Richard, Sharifah Osman, and Kevin Lowrence
- Subjects
Micro-credential ,Digital badges ,Digital learning identity ,COLLES ,Higher educational institutions ,OpenLearning ,Special aspects of education ,LC8-6691 ,Information technology ,T58.5-58.64 - Abstract
Abstract Micro-credentials have gained much popularity in recent years, and their popularity has skyrocketed due to emergency remote teaching instigated by the pandemic. It has been defined as a platform that provides credentials based on validated competencies. Nevertheless, in Malaysian HEI, such a concept is still novel and identifying insights on the benefits, challenges, and application are still scarce. Similarly, it was observed that there is a lack of observation on how students’ digital learning identity and their perception of professional relevance are influenced by such platform. Henceforth, based on the adapted enriched virtual model approach, a micro-credentials course was implemented to complement the new “normal” classes for a pre-service teacher’s instructional design course. A mixed-method triangulation design was used to explore the qualitative findings operationalized by open-ended questions (N = 74) with data obtained from the Digital Learning Identity Survey (DLIS) and Constructivist On-Line Learning Environment Survey (COLLES) (N = 72). The findings indicated that respondents had an overall positive perception of the use of micro-credentials to complement and overcome online learning challenges mainly due to substandard internet connectivity; nevertheless, they are unaware of the value of such credentials in their future profession. Conversely, their new identity as digital learners and experiences with a blended approach of online learning, especially with micro-credentials, was successful in shaping their identity as aspiring educators that embrace technology for teaching and learning.
- Published
- 2022
- Full Text
- View/download PDF
148. A Video Content Independent Mining Algorithm for Evolved Rule-based Detection of Scene Boundaries
- Author
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Tek Sheng Kevin Lo and Marios C. Angelides
- Subjects
Data stream ,business.industry ,Computer science ,Multimedia database ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Genetic programming ,Rule-based system ,Image segmentation ,computer.software_genre ,Video tracking ,Computer vision ,Segmentation ,Artificial intelligence ,Data mining ,business ,computer ,Information Systems ,Content management - Abstract
Segmentation of video data stream aims to divide the stream into temporally shorter, meaningful and manageable segments. This is the first step towards content-based multimedia database management, contented-based retrieval and browsing, and is very important to many other applications that aim to work with content. This paper presents a novel video mining algorithm that uses genetic programming for evolved rule-based scene boundary detection and whose key advantage is that is video content independent. Hence, the algorithm can be applied without modification to different video sequences just by feeding it different training data.
- Published
- 2005
149. Deliberating on the energy cap in China: the key to a low-carbon future?
- Author
-
Kevin Lo
- Subjects
chemistry ,Environmental protection ,Key (cryptography) ,chemistry.chemical_element ,Business ,China ,Carbon ,Energy (signal processing) ,General Environmental Science - Published
- 2013
150. Irrigation Water and Nitrogen Fertilizer Management in Potato (Solanum tuberosum L.): A Review
- Author
-
Bhimsen Shrestha, Murali Darapuneni, Blair L. Stringam, Kevin Lombard, and Koffi Djaman
- Subjects
irrigation ,nitrogen fertilizer ,yield ,quality ,potato ,Agriculture - Abstract
Intensive irrigation and nutrient management practices in agriculture have given rise to serious issues in aquifer water depletion and groundwater quality. This review discusses the effects of irrigation and nitrogen management practices on potato growth, yield, and quality, and their impacts on water and nitrogen use efficiencies. This review also highlights the economics and consequences of applying deficit irrigation strategies in potato production. Many researchers have demonstrated that excessive irrigation and nitrogen application rates negatively impact potato tuber yield and quality while also increasing nitrate leaching, energy consumption, and the overall costs of production. An application of light-to-moderate deficit irrigation (10–30% of full irrigation) together with reduced nitrogen rates (60–170 kg/ha) has a great potential to improve water and nitrogen use efficiencies while obtaining optimum yield and quality in potato production, depending on the climate, variety, soil type, and water availability. There is an opportunity to reduce N application rates in potato production through deficit irrigation practices by minimizing nitrate leaching beyond the crop root zone. The best irrigation and nitrogen management techniques for potato production, as discussed in this review, include using sprinkle and drip irrigation techniques, irrigation scheduling based on local crop coefficients, soil moisture content, and crop modeling techniques, applying slow-release nitrogenous fertilizers, split nitrogen application, and applying water and nitrogenous fertilizers in accordance with crop growth stage requirements.
- Published
- 2023
- Full Text
- View/download PDF
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