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119 results on '"Kennes, D."'

118. Changes in naloxone and haloperidol effects during the development of captivity-induced jumping stereotypy in bank voles.

Author

Kennes D, Odberg FO, Bouquet Y, and De Rycke PH

Subjects
Aging physiology, Animals, Arvicolinae physiology, Haloperidol pharmacology, Naloxone pharmacology, Stereotyped Behavior drug effects
Abstract

Captivity-induced stereotypies in bank voles (Clethrionomys glareolus) were inhibited at the age of 1, 2, 4, 6, 8 and 10 months by 0.2 mg/kg haloperidol s.c., while 35 mg/kg naloxone s.c. only inhibited them at the age of 4-6 months. Other activities were not significantly inhibited. The change in the naloxone effect was not due to desensitization as animals treated only at 6 or 8 months reacted similarly. It is suggested that the expression of such stereotypies is influenced by endogeneous brain opioid peptides during an early stage of their development, but that thereafter only motoric automatisms remain, essentially under dopaminergic control.

Published
1988
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119. The effect of interference in catecholamine biosynthesis on captivity-induced jumping stereotypy in bank voles (Clethrionomys glareolus).

Author

Odberg FO, Kennes D, De Rycke PH, and Bouquet Y

Subjects
Animals, Dopamine metabolism, Environment, Levodopa pharmacology, Methyltyrosines pharmacology, Norepinephrine pharmacology, alpha-Methyltyrosine, Arvicolinae metabolism, Catecholamines biosynthesis, Stereotyped Behavior physiology
Abstract

The level of the captivity-induced jumping stereotypy in bank voles was significantly decreased by 150 and 200 mg/kg alpha-methyl-para-tyrosine and increased by 200 mg/kg L-DOPA while 20 and 40 mg/kg fusaric acid had no effect. None of the other movements were affected by these drugs (as measured by a general activity meter), except for a nonsignificant decrease after treatment with fusaric acid. These results suggest that cerebral dopaminergic neuronal systems and not noradrenergic neuronal systems are involved in the expression of that stereotypy in bank voles.

Published
1987

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