101. Urinary Endothelin-1 Activity at the Relief of Urinary Tract Obstruction in Congenital Hydronephrotic Patients
- Author
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Shotaro Sato, Kazuhide Saito, Takeshi Komeyama, Yasushi Katayama, Toshiki Tsutsui, and Masayuki Takeda
- Subjects
medicine.medical_specialty ,business.industry ,Urinary system ,Urology ,Medicine ,General Medicine ,business ,Urinary tract obstruction ,medicine.disease ,Endothelin 1 - Abstract
To indicate renal disorders and to predict the prognosis of renal function, we investigated the significance of endothelin-I (ET-1) in retained urine, which was collected at the relief of urinary tract obstruction in 20 congenital hydronephrotic patients. Urinary ET-1 level ranged from 15 to 1411 pg/mg creatinine (Cr), and was higher than in normal Subjects in many cases. The value showed a positive correlation with the N-acetyl-β-Dglucosaminidase level (U/gCr) (r=0.663, p < 0.01) and β-2-microglobulin level (μg/mgCr) (r=0.486, p < 0.05). There was no significant correlation between ET-1 and albumin level. Immunohistochemical staining of renal tissue specimens showed ET-1 positivity in part of the medullary tubular epithelia of both normal and hydronephrotic kidneys, but no difference was seen between normal and hydronephrotic kidneys. These data suggest that urinary ET-1 level is a potential indicator of renal tubular disorders in hydronephrotic patients.
- Published
- 1993