30,005 results on '"Kanzaki A"'
Search Results
102. Talar component subsidence correlates with periprosthetic osteolysis after total ankle arthroplasty
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Kihara, Shinsuke, Kanzaki, Noriyuki, Yamashita, Takahiro, Yamamoto, Tetsuya, Nishida, Kyohei, Nagai, Kanto, Araki, Daisuke, Hoshino, Yuichi, Matsushita, Takehiko, and Kuroda, Ryosuke
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- 2023
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103. Real-world clinical outcomes of treatment with molnupiravir for patients with mild-to-moderate coronavirus disease 2019 during the Omicron variant pandemic
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Suzuki, Yasuhito, Shibata, Yoko, Minemura, Hiroyuki, Nikaido, Takefumi, Tanino, Yoshinori, Fukuhara, Atsuro, Kanno, Ryuzo, Saito, Hiroyuki, Suzuki, Shuzo, Inokoshi, Yayoi, Sando, Eiichiro, Sakuma, Hirofumi, Kobayashi, Tatsuho, Kume, Hiroaki, Kamimoto, Masahiro, Aoki, Hideko, Takama, Akira, Iizuka, Taku, Kamiyama, Takamichi, Nakayama, Masaru, Saito, Kiyoshi, Tanigawa, Koichi, Sato, Masahiko, Waragai, Yuichi, Kambe, Toshiyuki, Kanzaki, Norio, Azuma, Teruhisa, Okamoto, Hiromasa, Sakamoto, Keiji, Nakamura, Yuichi, Ohtani, Hiroshi, Waragai, Mitsuru, Maeda, Shinsaku, Ishida, Tokiya, Sugino, Keishi, Abe, Wataru, Tsukada, Yasuhiko, Lee, Tomoyoshi, Yamada, Ryuki, Sato, Riko, Onuma, Takumi, Tomita, Hikaru, Saito, Mikako, Watanabe, Natsumi, Rikimaru, Mami, Kawamata, Takaya, Morimoto, Julia, Togawa, Ryuichi, Sato, Yuki, Saito, Junpei, Kanazawa, Kenya, Hamaguchi, Sugihiro, and Iseki, Ken
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- 2023
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104. Phase Ib trial of durvalumab plus tremelimumab in combination with particle therapy in patients with advanced hepatocellular carcinoma with macrovascular invasion: DEPARTURE trial.
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Koroki, Keisuke, Ogasawara, Sadahisa, Makishima, Hirokazu, Wakatsuki, Masaru, Takahashi, Asahi, Kanzaki, Hiroaki, Kobayashi, Kazufumi, Inoue, Masanori, Kiyono, Soichiro, Nakamura, Masato, Kanogawa, Naoya, Kondo, Takayuki, Nakamoto, Shingo, Shiko, Yuki, Ozawa, Yoshihito, Inaba, Yosuke, Kurokawa, Tomoya, Hanaoka, Hideki, Yamada, Shigeru, and Kato, Naoya
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- 2024
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105. Experimental Results for Mars Rotorcraft Airfoils (roamx-0201 and clf5605) at Low Reynolds Number and Compressible Flow in a Mars Wind Tunnel
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Witold J F Koning, Natalia Perez Perez, Haley V Cummings, Takayuki Nagata, Yudai Kanzaki, Miku Kasai, Muku Miyagi, Taku Nonomura, Keisuke Asai, Lidia Caros, Oliver Buxton, and Peter Vincent
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Aeronautics (General) - Abstract
Experimental results are obtained for a roamx-0201 type airfoil and the clf5605 airfoil at highsubsonic, low Reynolds number conditions using the Tohoku University Mars Wind Tunnel, Japan. The tests are conducted at a Mach number of M = 0.60, and a Reynolds number of Re = 20,000 to reflect representative aerodynamics of a rotor blade for Mars exploration. The angle of attack is varied between α = −2.0 deg and α = 6.0 deg. The roamx-0201 type airfoil is an unconventional airfoil optimized for the chosen tunnel operating conditions using the Evolutionary aLgorithm for Iterative Studies of Aeromechanics (ELISA), developed under the Rotor Optimization for the Advancement of Mars eXploration (ROAMX) project. ELISA is utilized here to optimize aerodynamic airfoil performance using a Genetic Algorithm and two-dimensional high-fidelity CFD simulations, ultimately resulting in a Pareto-optimal airfoil set. The clf5605 airfoil is the outboard airfoil used on the Ingenuity Mars Helicopter and provides a baseline against which the roamx-0201, as well as possible future airfoil profiles for the compressible low Reynolds number regime, can be compared against. Lift and drag data are recorded using a balance, pressure distributions are obtained using Pressure Sensitive Paint (PSP) application, and Schlieren images are obtained to visualize the flowfield. The data is tabulated to aid future research.
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- 2024
106. The Effects of Speaking Activities on Brain Blood Flow: An NIRS Study
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Negishi, Junko, Kanzaki, Hiroyuki, Yamada, Yuko, Murakami, Masumi, Ozawa, Erika, and Nakamura, Yoshiyuki
- Abstract
This study explored appropriate speaking activities for speakers of different proficiency levels by measuring the changes in their brain blood flow with near-infrared spectroscopy (NIRS). Fifty adult speakers and learners of English of various proficiency levels participated in the study by undertaking four types of task: a single-speaker picture description, interview, and two paired interaction activities on an easy and a difficult topic. By objectively analyzing the collected data, the authors revealed which speaking activity facilitated brain activity, which speaking activity was suitable for which level of learner, and from which area of the brain it was possible to obtain activation data. In short, advanced language learners need to tackle more difficult tasks, while easy, patterned tasks such as the picture description and interview are more appropriate for elementary level learners. As for intermediate learners, their language learning is likely to be promoted through most of the activity types, except for the interactions on difficult topics, which were shown to decrease their brain blood flow.
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- 2020
107. Mixed pathophysiologies of lamellar macular holes and related diseases: a multimodal optical coherence tomography-based study
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Matoba, Ryo, Kanzaki, Yuki, Morita, Tetsuro, Masuda, Yuki, Kimura, Shuhei, Hosokawa, Mio M, Shiode, Yusuke, and Morizane, Yuki
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- 2024
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108. Temporal characteristics of turbulent flow and moth orientation behaviour patterns with fluent simulation and moth-based moving model simulation
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Liu, Yanting and Kanzaki, Ryohei
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- 2024
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109. Significance of Pulmonary Artery Dilatation in Lung Cancer Patients With Chronic Obstructive Pulmonary Disease Who Underwent Pulmonary Resection
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Kanzaki, Ryu, Watari, Hirokazu, Omura, Akiisa, Kawagishi, Sachi, Tanaka, Ryo, Maniwa, Tomohiro, Fujii, Makoto, and Okami, Jiro
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- 2024
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110. Predictability of noninvasive liver fibrosis score for cardiac events in patients with nonalcoholic fatty liver disease
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Shibata, Naoki, Ito, Takanori, Toyoda, Hidenori, Tanaka, Akihito, Morita, Yasuhiro, Kanzaki, Yasunori, Watanabe, Naoki, Yoshioka, Naoki, Yasuda, Satoshi, and Morishima, Itsuro
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- 2024
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111. Brønsted acidity of bis(trifluoromethanesulfonyl)amide and trifluoromethanesulfonic acid in ionic liquids of ternary ammonium
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Kanzaki, Ryo, Hidaka, Tomoya, Tokuda, Yuki, Kodamatani, Hitoshi, and Tomiyasu, Takashi
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- 2024
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112. Goal Orientation and Desire for Approval Were Associated With Sports Injuries Among Young Japanese Athletes
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Kimotsuki, Yukiko, Ogasawara, Issei, Iwasaki, Susumu, Nagai, Kanto, Nishida, Kyohei, Kanzaki, Noriyuki, Hoshino, Yuichi, Matsushita, Takehiko, Kuroda, Ryosuke, Uchida, Ryohei, Take, Yasuhiro, and Nakata, Ken
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- 2024
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113. Accuracy of Shunt Volume Measured by Three-Dimensional Echocardiography and Cardiac Magnetic Resonance in Patients With an Atrial Septal Defect and a Dilated Right Ventricle
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Yanagi, Yoshiki, Amano, Masashi, Tamai, Yurie, Mizumoto, Ayaka, Nakagawa, Shoko, Moriuchi, Kenji, Asano, Ryotaro, Kurashima, Shinichi, Irie, Yuki, Sakamoto, Takahiro, Amaki, Makoto, Kanzaki, Hideaki, Ohta, Yasutoshi, Morita, Yoshiaki, Ogo, Takeshi, Kitai, Takeshi, and Izumi, Chisato
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- 2024
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114. Association between tumor cell in air space and treatment outcomes in early-stage lung cancer treated with stereotactic body radiation therapy
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Makita, Kenji, Hamamoto, Yasushi, Kanzaki, Hiromitsu, Nagasaki, Kei, Matsuki, Hirokazu, Inoue, Koji, and Kozuki, Toshiyuki
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- 2024
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115. Erratum: Helicity amplitudes without gauge cancellation for electroweak processes
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Chen, Junmou, Hagiwara, Kaoru, Kanzaki, Junichi, and Mawatari, Kentarou
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- 2024
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116. CBT EFFECTIVENESS FOR REDUCING PTSD: A META-ANALYSIS STUDY
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Petrick Pratama, Ananta Yudiarso, and Kanzaki Mami
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Psychology ,BF1-990 - Abstract
PTSD terjadi pada individu yang telah atau sedang mengalami peristiwa traumatis. CBT adalah intervensi tanpa penggunaan obat yang dapat digunakan untuk mengurangi PTSD. Pembahasan yang bersifat konklusif seperti penelitian meta-analisis diperlukan untuk bisa menilai secara keseluruhan keberdampakan CBT terhadap PTSD. Penelitian meta-analisis dilakukan pada 14 jurnal penelitian yang diakses dengan menggunakan sarana peramban Google Chrome. Rentang waktu rilis publikasi yang akan dianalisis adalah pada kurun waktu 10 tahun terakhir. Sebanyak 898 partisipan terdiri dari 441 kelompok eksperimental dan 457 kelompok kontrol. Data dianalisis dengan menggunakan analisis statistik ukuran efek Cohen's d, hasilnya adalah mean (M), standard deviation (SD), dan ukuran sampel (N) untuk menghasilkan ukuran efek menggunakan efek campuran dengan Hedges'g sebesar 1,18, CI = 0,283 hingga 2,093 dengan nilai ketidaksesuaian (inconsistency value/I2) = 87,2%. CBT memiliki efek yang besar dalam mengurangi PTSD. Implikasi penelitian ini, peneliti dapat terus memberikan kontribusi dalam melakukan variasi CBT untuk PTSD.
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- 2024
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117. Applications of machine learning in surge prediction for vehicle turbochargers
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Hiroki Saito, Dai Kanzaki, and Kazuo Yonekura
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Machine learning ,Neural network ,Turbochargers ,Surging ,Cybernetics ,Q300-390 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Surging in vehicle turbochargers is an important phenomenon that can damage the compressor and its peripheral equipment due to pressure fluctuations and vibration, so it is essential to understand the operating points where surging occurs. In this paper, we constructed a Neural Network (NN) that can predict these operating points, using as explanatory variables the geometry parameters of the vehicle turbocharger and one-dimensional predictions of the flow rates at surge. Our contribution is the use of machine learning to enable fast and low-cost prediction of surge points, which is usually only available through experiments or calculation-intensive Computational Fluid Dynamics (CFD). Evaluations conducted on the test data revealed that prediction accuracy was poor for some turbocharger geometries and operating conditions, and that this was associated with the relatively small data quantity included in the training data. Expanding the appropriate data offers some prospect of improving prediction accuracy.
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- 2024
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118. Odorant-sensing cell micropatterns for odor discrimination
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Shinya Yamahira, Hidefumi Mitsuno, Misato Yamaoka, Teruyuki Nagamune, Akimitsu Okamoto, Ryohei Kanzaki, and Satoshi Yamaguchi
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Odor biosensor ,Cell patterning ,Integrated biosensor ,PEG-Lipid ,Photo-responsive material ,Biotechnology ,TP248.13-248.65 - Abstract
A technology that can effectively distinguish between various odorants with high sensitivity and selectivity has numerous applications ranging from water quality testing to disease diagnosis. Here, we report a cell-based odorant-sensing display that utilizes Sf21 cells expressing odorant receptors, co-receptors, and a calcium-sensitive fluorescent protein as the sensing elements for detecting multiple odorants. Integrated micropatterns of the sensor cells in a few hundred micrometer-size patterns were fabricated on photoactivatable cell-anchoring surfaces consisting of photo-responsive polymeric materials. In the microfluidic system equipped with the sensing display, the injection of two model odorants, such as Bombykal and 1-octen-3-ol, at micro-molar concentrations resulted in selective and rapid fluorescence emission from the corresponding sensor cell patterns. Furthermore, when both odorants were injected together, the fluorescence from each corresponding sensor cell could be observed simultaneously. This study provides the proof of principle that the current cell patterning system enables the discrimination of odors, including multiple odorants, through a finely patterned sensing display on the device.
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- 2024
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119. Thermodynamic Measurements: Potentiometry, UV/Vis Spectrometry and Calorimetry
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Kanzaki, Ryo, primary
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- 2023
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120. Computational Complexity of Jumping Block Puzzles
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Kanzaki, Masaaki, Otachi, Yota, and Uehara, Ryuhei
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Computer Science - Computational Complexity - Abstract
In combinatorial reconfiguration, the reconfiguration problems on a vertex subset (e.g., an independent set) are well investigated. In these problems, some tokens are placed on a subset of vertices of the graph, and there are three natural reconfiguration rules called ``token sliding,'' ``token jumping,'' and ``token addition and removal''. In the context of computational complexity of puzzles, the sliding block puzzles play an important role. Depending on the rules and set of pieces, the sliding block puzzles characterize the computational complexity classes including P, NP, and PSPACE. The sliding block puzzles correspond to the token sliding model in the context of combinatorial reconfiguration. On the other hand, a relatively new notion of jumping block puzzles is proposed in puzzle society. This is the counterpart to the token jumping model of the combinatorial reconfiguration problems in the context of block puzzles. We investigate several variants of jumping block puzzles and determine their computational complexities.
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- 2021
121. Epiretinal Membrane Impairs the Inner Retinal Layer in a Traction Force-Dependent Manner
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Kanzaki, Yuki, Matoba, Ryo, Kimura, Shuhei, Hosokawa, Mio M., Shiode, Yusuke, Doi, Shinichiro, Morita, Tetsuro, Kanzaki, Sayumi, Takasu, Ippei, Tanikawa, Atsuhiro, and Morizane, Yuki
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- 2023
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122. Utility of needle biopsy in centrally located lung cancer for genome analysis: a retrospective cohort study
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Kei Kunimasa, Shingo Matsumoto, Keiichiro Honma, Motohiro Tamiya, Takako Inoue, Takahisa Kawamura, Satoshi Tanada, Akito Miyazaki, Ryu Kanzaki, Tomohiro Maniwa, Jiro Okami, Yuji Matsumoto, Koichi Goto, and Kazumi Nishino
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Lung cancer diagnosis ,Next-generation sequencing ,Sampling method ,NGS success rate ,Re-biopsy ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background It is essential to collect a sufficient amount of tumor tissue for successful next-generation sequencing (NGS) analysis. In this study, we investigated the clinical risk factors for avoiding re-biopsy for NGS analysis (re-genome biopsy) in cases where a sufficient amount of tumor tissue could not be collected by bronchoscopy. Methods We investigated the association between clinical factors and the risk of re-genome biopsy in patients who underwent transbronchial biopsy (TBB) or endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and required re-genome biopsy in cases enrolled in LC-SCRUM Asia, a prospective nationwide genome screening project in Japan. We also examined whether the frequency of re-genome biopsy decreased between the first and second halves of the enrolment period. Results Of the 572 eligible patients, 236 underwent TBB, and 134 underwent EBUS-TBNA. Twenty-four TBBs required re-genome biopsy, and multivariate analysis showed that the risk of re-genome biopsy was significantly increased in lesions where the tumor lesion was centrally located. In these cases, EBUS-TBNA should be utilized even if the lesion is a pulmonary lesion. However, it should be noted that even with EBUS-TBNA, lung field lesions are at a higher risk of re-canalization than mediastinal lymph node lesions. It was also found that even when tumor cells were detected in rapid on-site evaluation, a sufficient amount of tumor tissue was not always collected. Conclusions For centrally located pulmonary mass lesions, EBUS-TBNA, rather than TBB, can be used to obtain tumor tissues that can be analyzed by NGS.
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- 2023
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123. Erratum to: Search for exclusive Higgs and Z boson decays to ϕγ and ργ with the ATLAS detector
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The ATLAS collaboration, M. Aaboud, G. Aad, B. Abbott, O. Abdinov, B. Abeloos, S. H. Abidi, O. S. AbouZeid, N. L. Abraham, H. Abramowicz, H. Abreu, R. Abreu, Y. Abulaiti, B. S. Acharya, S. Adachi, L. Adamczyk, J. Adelman, M. Adersberger, T. Adye, A. A. Affolder, Y. Afik, T. Agatonovic-Jovin, C. Agheorghiesei, J. A. Aguilar-Saavedra, S. P. Ahlen, F. Ahmadov, G. Aielli, S. Akatsuka, H. Akerstedt, T. P. A. Åkesson, E. Akilli, A. V. Akimov, G. L. Alberghi, J. Albert, P. Albicocco, M. J. Alconada Verzini, S. C. Alderweireldt, M. Aleksa, I. N. Aleksandrov, C. Alexa, G. Alexander, T. Alexopoulos, M. Alhroob, B. Ali, M. Aliev, G. Alimonti, J. Alison, S. P. Alkire, B. M. M. Allbrooke, B. W. Allen, P. P. Allport, A. Aloisio, A. Alonso, F. Alonso, C. Alpigiani, A. A. Alshehri, M. I. Alstaty, B. Alvarez Gonzalez, D. Álvarez Piqueras, M. G. Alviggi, B. T. Amadio, Y. Amaral Coutinho, C. Amelung, D. Amidei, S. P. Amor Dos Santos, S. Amoroso, G. Amundsen, C. Anastopoulos, L. S. Ancu, N. Andari, T. Andeen, C. F. Anders, J. K. Anders, K. J. Anderson, A. Andreazza, V. Andrei, S. Angelidakis, I. Angelozzi, A. Angerami, A. V. Anisenkov, N. Anjos, A. Annovi, C. Antel, M. Antonelli, A. Antonov, D. J. Antrim, F. Anulli, M. Aoki, L. Aperio Bella, G. Arabidze, Y. Arai, J. P. Araque, V. Araujo Ferraz, A. T. H. Arce, R. E. Ardell, F. A. Arduh, J-F. Arguin, S. Argyropoulos, M. Arik, A. J. Armbruster, L. J. Armitage, O. Arnaez, H. Arnold, M. Arratia, O. Arslan, A. Artamonov, G. Artoni, S. Artz, S. Asai, N. Asbah, A. Ashkenazi, L. Asquith, K. Assamagan, R. Astalos, M. Atkinson, N. B. Atlay, K. Augsten, G. Avolio, B. Axen, M. K. Ayoub, G. Azuelos, A. E. Baas, M. J. Baca, H. Bachacou, K. Bachas, M. Backes, P. Bagnaia, M. Bahmani, H. Bahrasemani, J. T. Baines, M. Bajic, O. K. Baker, P. J. Bakker, E. M. Baldin, P. Balek, F. Balli, W. K. Balunas, E. Banas, A. Bandyopadhyay, Sw. Banerjee, A. A. E. Bannoura, L. Barak, E. L. Barberio, D. Barberis, M. Barbero, T. Barillari, M.-S. Barisits, J. T. Barkeloo, T. Barklow, N. Barlow, S. L. Barnes, B. M. Barnett, R. M. Barnett, Z. Barnovska-Blenessy, A. Baroncelli, G. Barone, A. J. Barr, L. Barranco Navarro, F. Barreiro, J. Barreiro Guimarães da Costa, R. Bartoldus, A. E. Barton, P. Bartos, A. Basalaev, A. Bassalat, R. L. Bates, S. J. Batista, J. R. Batley, M. Battaglia, M. Bauce, F. Bauer, H. S. Bawa, J. B. Beacham, M. D. Beattie, T. Beau, P. H. Beauchemin, P. Bechtle, H. P. Beck, H. C. Beck, K. Becker, M. Becker, C. Becot, A. J. Beddall, A. Beddall, V. A. Bednyakov, M. Bedognetti, C. P. Bee, T. A. Beermann, M. Begalli, M. Begel, J. K. Behr, A. S. Bell, G. Bella, L. Bellagamba, A. Bellerive, M. Bellomo, K. Belotskiy, O. Beltramello, N. L. Belyaev, O. Benary, D. Benchekroun, M. Bender, N. Benekos, Y. Benhammou, E. Benhar Noccioli, J. Benitez, D. P. Benjamin, M. Benoit, J. R. Bensinger, S. Bentvelsen, L. Beresford, M. Beretta, D. Berge, E. Bergeaas Kuutmann, N. Berger, L. J. Bergsten, J. Beringer, S. Berlendis, N. R. Bernard, G. Bernardi, C. Bernius, F. U. Bernlochner, T. Berry, P. Berta, C. Bertella, G. Bertoli, I. A. Bertram, C. Bertsche, G. J. Besjes, O. Bessidskaia Bylund, M. Bessner, N. Besson, A. Bethani, S. Bethke, A. Betti, A. J. Bevan, J. Beyer, R. M. Bianchi, O. Biebel, D. Biedermann, R. Bielski, K. Bierwagen, N. V. Biesuz, M. Biglietti, T. R. V. Billoud, H. Bilokon, M. Bindi, A. Bingul, C. Bini, S. Biondi, T. Bisanz, C. Bittrich, D. M. Bjergaard, J. E. Black, K. M. Black, R. E. Blair, T. Blazek, I. Bloch, C. Blocker, A. Blue, U. Blumenschein, Dr. Blunier, G. J. Bobbink, V. S. Bobrovnikov, S. S. Bocchetta, A. Bocci, C. Bock, M. Boehler, D. Boerner, D. Bogavac, A. G. Bogdanchikov, C. Bohm, V. Boisvert, P. Bokan, T. Bold, A. S. Boldyrev, A. E. Bolz, M. Bomben, M. Bona, M. Boonekamp, A. Borisov, G. Borissov, J. Bortfeldt, D. Bortoletto, V. Bortolotto, D. Boscherini, M. Bosman, J. D. Bossio Sola, J. Boudreau, E. V. Bouhova-Thacker, D. Boumediene, C. Bourdarios, S. K. Boutle, A. Boveia, J. Boyd, I. R. Boyko, A. J. Bozson, J. Bracinik, A. Brandt, G. Brandt, O. Brandt, F. Braren, U. Bratzler, B. Brau, J. E. Brau, W. D. Breaden Madden, K. Brendlinger, A. J. Brennan, L. Brenner, R. Brenner, S. Bressler, D. L. Briglin, T. M. Bristow, D. Britton, D. Britzger, F. M. Brochu, I. Brock, R. Brock, G. Brooijmans, T. Brooks, W. K. Brooks, J. Brosamer, E. Brost, J. H. Broughton, P. A. Bruckman de Renstrom, D. Bruncko, A. Bruni, G. Bruni, L. S. Bruni, S. Bruno, B. H. Brunt, M. Bruschi, N. Bruscino, P. Bryant, L. Bryngemark, T. Buanes, Q. Buat, P. Buchholz, A. G. Buckley, I. A. Budagov, F. Buehrer, M. K. Bugge, O. Bulekov, D. Bullock, T. J. Burch, S. Burdin, C. D. Burgard, A. M. Burger, B. Burghgrave, K. Burka, S. Burke, I. Burmeister, J. T. P. Burr, D. Büscher, V. Büscher, P. Bussey, J. M. Butler, C. M. Buttar, J. M. Butterworth, P. Butti, W. Buttinger, A. Buzatu, A. R. Buzykaev, S. Cabrera Urbán, D. Caforio, H. Cai, V. M. Cairo, O. Cakir, N. Calace, P. Calafiura, A. Calandri, G. Calderini, P. Calfayan, G. Callea, L. P. Caloba, S. Calvente Lopez, D. Calvet, S. Calvet, T. P. Calvet, R. Camacho Toro, S. Camarda, P. Camarri, D. Cameron, R. Caminal Armadans, C. Camincher, S. Campana, M. Campanelli, A. Camplani, A. Campoverde, V. Canale, M. Cano Bret, J. Cantero, T. Cao, M. D. M. Capeans Garrido, I. Caprini, M. Caprini, M. Capua, R. M. Carbone, R. Cardarelli, F. Cardillo, I. Carli, T. Carli, G. Carlino, B. T. Carlson, L. Carminati, R. M. D. Carney, S. Caron, E. Carquin, S. Carrá, G. D. Carrillo-Montoya, D. Casadei, M. P. Casado, A. F. Casha, M. Casolino, D. W. Casper, R. Castelijn, V. Castillo Gimenez, N. F. Castro, A. Catinaccio, J. R. Catmore, A. Cattai, J. Caudron, V. Cavaliere, E. Cavallaro, D. Cavalli, M. Cavalli-Sforza, V. Cavasinni, E. Celebi, F. Ceradini, L. Cerda Alberich, A. S. Cerqueira, A. Cerri, L. Cerrito, F. Cerutti, A. Cervelli, S. A. Cetin, A. Chafaq, D. Chakraborty, S. K. Chan, W. S. Chan, Y. L. Chan, P. Chang, J. D. Chapman, D. G. Charlton, C. C. Chau, C. A. Chavez Barajas, S. Che, S. Cheatham, A. Chegwidden, S. Chekanov, S. V. Chekulaev, G. A. Chelkov, M. A. Chelstowska, C. Chen, H. Chen, J. Chen, S. Chen, X. Chen, Y. Chen, H. C. Cheng, H. J. Cheng, A. Cheplakov, E. Cheremushkina, R. Cherkaoui El Moursli, E. Cheu, K. Cheung, L. Chevalier, V. Chiarella, G. Chiarelli, G. Chiodini, A. S. Chisholm, A. Chitan, Y. H. Chiu, M. V. Chizhov, K. Choi, A. R. Chomont, S. Chouridou, Y. S. Chow, V. Christodoulou, M. C. Chu, J. Chudoba, A. J. Chuinard, J. J. Chwastowski, L. Chytka, A. K. Ciftci, D. Cinca, V. Cindro, I. A. Cioară, A. Ciocio, F. Cirotto, Z. H. Citron, M. Citterio, M. Ciubancan, A. Clark, B. L. Clark, M. R. Clark, P. J. Clark, R. N. Clarke, C. Clement, Y. Coadou, M. Cobal, A. Coccaro, J. Cochran, L. Colasurdo, B. Cole, A. P. Colijn, J. Collot, T. Colombo, P. Conde Muiño, E. Coniavitis, S. H. Connell, I. A. Connelly, S. Constantinescu, G. Conti, F. Conventi, M. Cooke, A. M. Cooper-Sarkar, F. Cormier, K. J. R. Cormier, M. Corradi, F. 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Yamazaki, Y. Yamazaki, Z. Yan, H. Yang, Y. Yang, Z. Yang, W-M. Yao, Y. C. Yap, Y. Yasu, E. Yatsenko, K. H. Yau Wong, J. Ye, S. Ye, I. Yeletskikh, E. Yigitbasi, E. Yildirim, K. Yorita, K. Yoshihara, C. Young, C. J. S. Young, J. Yu, S. P. Y. Yuen, I. Yusuff, B. Zabinski, G. Zacharis, R. Zaidan, A. M. Zaitsev, N. Zakharchuk, J. Zalieckas, A. Zaman, S. Zambito, D. Zanzi, C. Zeitnitz, G. Zemaityte, A. Zemla, J. C. Zeng, Q. Zeng, O. Zenin, T. Ženiš, D. Zerwas, D. Zhang, F. Zhang, G. Zhang, H. Zhang, J. Zhang, L. Zhang, M. Zhang, P. Zhang, R. Zhang, X. Zhang, Y. Zhang, Z. Zhang, X. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, B. Zhou, C. Zhou, L. Zhou, M. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, H. Zhu, J. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, A. Zibell, D. Zieminska, N. I. Zimine, C. Zimmermann, S. Zimmermann, Z. Zinonos, M. Zinser, M. Ziolkowski, L. Živković, G. Zobernig, A. Zoccoli, R. Zou, M. zur Nedden, and L. Zwalinski
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Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Published
- 2023
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124. LAG3 is an independent prognostic biomarker and potential target for immune checkpoint inhibitors in malignant pleural mesothelioma: a retrospective study
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Ken Arimura, Kenzo Hiroshima, Yoji Nagashima, Tadao Nakazawa, Akira Ogihara, Mami Orimo, Yasuto Sato, Hideki Katsura, Masato Kanzaki, Mitsuko Kondo, and Etsuko Tagaya
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LAG3 ,Immune checkpoint inhibitors ,Malignant pleural mesothelioma ,Novel prognostic biomarker ,TCGA ,mRNA ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Lymphocyte-activation gene 3 (LAG3) is an immune checkpoint receptor; novel LAG3 immune checkpoint inhibitors (ICIs) exhibit therapeutic activity in melanoma. The role of LAG3and ICIs of LAG3 are unknown in malignant pleural mesothelioma (MPM). This study aimed to uncover the prognostic landscape of LAG3 in multiple cancers and investigate the potential of using LAG3 as an ICIs target in patients with MPM. Methods We used The Cancer Genome Atlas (TCGA) cohort for assessing mRNA expression and our cohort for immunohistochemical expression. TCGA cohort were analyzed using the Wilcoxon rank-sum test to compare mRNA expression between normal and tumor tissues in multiple cancers. We used 86 MPM cases from TCGA and 38 MPM cases from our cohort to analyze the expression of LAG3 in tumor-infiltrating lymphocytes. The mean LAG3 mRNA expression was set as the cut-off and samples were classified as positive/negative for immunohistochemical expression. Overall survival (OS) of patients with MPM was determined using the Kaplan–Meier method based on LAG3 mRNA and immunohistochemical expression. OS analysis was performed using the multivariate Cox proportional hazards model. The correlation of LAG3 expression and mRNA expression of tumor immune infiltration cells (TIICs) gene markers were estimated using Spearman correlation. To identify factors affecting the correlation of LAG3 mRNA expression, a multivariate linear regression model was performed. Results LAG3 mRNA was associated with prognosis in multiple cancers. Elevated LAG3 mRNA expression was correlated with a better prognosis in MPM. LAG3 expression was detected immunohistochemically in the membrane of infiltrating lymphocytes in MPM. LAG3 immunohistochemical expression was correlated with a better prognosis in MPM. The multivariate Cox proportional hazards model revealed that elevated LAG3 immunohistochemical expression indicated a better prognosis. In addition, LAG3 mRNA expression was correlated with the expression of various gene markers of TIICs, the most relevant to programmed cell death 1 (PD-1) with the multivariate linear regression model in MPM. Conclusions LAG3 expression was correlated with prognosis in multiple cancers, particularly MPM; LAG3 is an independent prognostic biomarker of MPM. LAG3 regulates cancer immunity and is a potential target for ICIs therapy. PD-1 and LAG3 inhibitors may contribute to a better prognosis in MPM. Trial registration This study was registered with UMIN000049240 (registration day: August 19, 2022) and approved by the Institutional Review Board (approval date: August 22, 2022; approval number: 2022–0048) at Tokyo Women’s Medical University.
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- 2023
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125. LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes
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Fumitaka Kawakami, Motoki Imai, Yuki Isaka, Mark R. Cookson, Hiroko Maruyama, Makoto Kubo, Matthew J. Farrer, Makoto Kanzaki, Rei Kawashima, Tatsunori Maekawa, Shun Tamaki, Yoshifumi Kurosaki, Fumiaki Kojima, Kenichi Ohba, and Takafumi Ichikawa
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adipocyte ,glucose tolerance ,GLUT4 ,LRRK2 ,Rab GTPase ,Biology (General) ,QH301-705.5 - Abstract
Epidemiological studies have shown that abnormalities of glucose metabolism are involved in leucine‐rich repeat kinase 2 (LRRK2)‐associated Parkinson's disease (PD). However, the physiological significance of this association is unclear. In the present study, we investigated the effect of LRRK2 on high‐fat diet (HFD)‐induced glucose intolerance using Lrrk2‐knockout (KO) mice. We found for the first time that HFD‐fed KO mice display improved glucose tolerance compared with their wild‐type (WT) counterparts. In addition, high serum insulin and leptin, as well as low serum adiponectin resulting from HFD in WT mice were improved in KO mice. Using western blotting, we found that Lrrk2 is highly expressed in adipose tissues compared with other insulin‐related tissues that are thought to be important in glucose tolerance, including skeletal muscle, liver, and pancreas. Lrrk2 expression and phosphorylation of its kinase substrates Rab8a and Rab10 were significantly elevated after HFD treatment in WT mice. In cell culture experiments, treatment with a LRRK2 kinase inhibitor stimulated insulin‐dependent membrane translocation of glucose transporter 4 (Glut4) and glucose uptake in mouse 3T3‐L1 adipocytes. We conclude that increased LRRK2 kinase activity in adipose tissue exacerbates glucose tolerance by suppressing Rab8‐ and Rab10‐mediated GLUT4 membrane translocation.
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- 2023
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126. Search for single vector-like B quark production and decay via B → bH( b b ¯ $$ b\overline{b} $$ ) in pp collisions at s $$ \sqrt{s} $$ = 13 TeV with the ATLAS detector
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The ATLAS collaboration, G. Aad, B. Abbott, D. C. Abbott, A. Abed Abud, K. Abeling, D. K. Abhayasinghe, S. H. Abidi, H. Abramowicz, H. Abreu, Y. Abulaiti, A. C. Abusleme Hoffman, B. S. Acharya, B. Achkar, L. Adam, C. Adam Bourdarios, L. Adamczyk, L. Adamek, J. Adelman, A. Adiguzel, S. Adorni, T. Adye, A. A. Affolder, Y. Afik, C. Agapopoulou, M. N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, J. A. Aguilar-Saavedra, A. Ahmad, F. Ahmadov, W. S. Ahmed, X. Ai, G. Aielli, S. Akatsuka, M. Akbiyik, T. P. A. Åkesson, A. V. Akimov, K. Al Khoury, G. L. Alberghi, J. Albert, M. J. Alconada Verzini, S. Alderweireldt, M. Aleksa, I. N. Aleksandrov, C. Alexa, T. Alexopoulos, A. Alfonsi, F. Alfonsi, M. Alhroob, B. Ali, S. Ali, M. Aliev, G. Alimonti, C. Allaire, B. M. M. Allbrooke, P. P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, E. Alunno Camelia, M. Alvarez Estevez, M. G. Alviggi, Y. Amaral Coutinho, A. Ambler, L. Ambroz, C. Amelung, D. Amidei, S. P. Amor Dos Santos, S. Amoroso, C. S. Amrouche, C. Anastopoulos, N. Andari, T. Andeen, J. K. Anders, S. Y. Andrean, A. Andreazza, V. Andrei, S. Angelidakis, A. Angerami, A. V. Anisenkov, A. Annovi, C. Antel, M. T. Anthony, E. Antipov, M. Antonelli, D. J. A. Antrim, F. Anulli, M. Aoki, J. A. Aparisi Pozo, M. A. Aparo, L. Aperio Bella, N. Aranzabal, V. Araujo Ferraz, C. Arcangeletti, A. T. H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, A. J. Armbruster, A. Armstrong, O. Arnaez, H. Arnold, Z. P. Arrubarrena Tame, G. Artoni, H. Asada, K. Asai, S. Asai, N. A. Asbah, E. M. Asimakopoulou, L. Asquith, J. Assahsah, K. Assamagan, R. Astalos, R. J. Atkin, M. Atkinson, N. B. Atlay, H. Atmani, P. A. Atmasiddha, K. Augsten, S. Auricchio, V. A. Austrup, G. Avolio, M. K. Ayoub, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, F. Backman, A. Badea, P. Bagnaia, H. Bahrasemani, A. J. Bailey, V. R. Bailey, J. T. Baines, C. Bakalis, O. K. Baker, P. J. Bakker, E. Bakos, D. Bakshi Gupta, S. Balaji, R. Balasubramanian, E. M. Baldin, P. Balek, E. Ballabene, F. Balli, W. K. Balunas, J. Balz, E. Banas, M. Bandieramonte, A. Bandyopadhyay, L. Barak, E. L. Barberio, D. Barberis, M. Barbero, G. Barbour, K. N. Barends, T. Barillari, M-S. Barisits, J. Barkeloo, T. Barklow, B. M. Barnett, R. M. Barnett, A. Baroncelli, G. Barone, A. J. Barr, L. Barranco Navarro, F. Barreiro, J. Barreiro Guimarães da Costa, U. Barron, S. Barsov, F. Bartels, R. Bartoldus, G. Bartolini, A. E. Barton, P. Bartos, A. Basalaev, A. Basan, I. Bashta, A. Bassalat, M. J. Basso, C. R. Basson, R. L. Bates, S. Batlamous, J. R. Batley, B. Batool, M. Battaglia, M. Bauce, F. Bauer, P. Bauer, H. S. Bawa, A. Bayirli, J. B. Beacham, T. Beau, P. H. Beauchemin, F. Becherer, P. Bechtle, H. P. Beck, K. Becker, C. Becot, A. J. Beddall, V. A. Bednyakov, C. P. Bee, T. A. Beermann, M. Begalli, M. Begel, A. Behera, J. K. Behr, C. Beirao Da Cruz E Silva, J. F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, K. Belotskiy, N. L. Belyaev, D. Benchekroun, Y. Benhammou, D. P. Benjamin, M. Benoit, J. R. Bensinger, S. Bentvelsen, L. Beresford, M. Beretta, D. Berge, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, L. J. Bergsten, J. Beringer, S. Berlendis, G. Bernardi, C. Bernius, F. U. Bernlochner, T. Berry, P. Berta, A. Berthold, I. A. Bertram, O. Bessidskaia Bylund, S. Bethke, A. Betti, A. J. Bevan, S. Bhatta, D. S. Bhattacharya, P. Bhattarai, V. S. Bhopatkar, R. Bi, R. M. Bianchi, O. Biebel, R. Bielski, N. V. Biesuz, M. Biglietti, T. R. V. Billoud, M. Bindi, A. Bingul, C. Bini, S. Biondi, C. J. Birch-sykes, G. A. Bird, M. Birman, T. Bisanz, D. Biswas, A. Bitadze, C. Bittrich, K. Bjørke, I. Bloch, C. Blocker, A. Blue, U. Blumenschein, J. Blumenthal, G. J. Bobbink, V. S. Bobrovnikov, D. Bogavac, A. G. Bogdanchikov, C. Bohm, V. Boisvert, P. Bokan, T. Bold, M. Bomben, M. Bona, M. Boonekamp, C. D. Booth, A. G. Borbély, H. M. Borecka-Bielska, L. S. Borgna, G. Borissov, D. Bortoletto, D. Boscherini, M. Bosman, J. D. Bossio Sola, K. Bouaouda, J. Boudreau, E. V. Bouhova-Thacker, D. Boumediene, R. Bouquet, A. Boveia, J. Boyd, D. Boye, I. R. Boyko, A. J. Bozson, J. Bracinik, N. Brahimi, G. Brandt, O. Brandt, F. Braren, B. Brau, J. E. Brau, W. D. Breaden Madden, K. Brendlinger, R. Brener, L. Brenner, R. Brenner, S. Bressler, B. Brickwedde, D. L. Briglin, D. Britton, D. Britzger, I. Brock, R. Brock, G. Brooijmans, W. K. Brooks, E. Brost, P. A. Bruckman de Renstrom, B. Brüers, D. Bruncko, A. Bruni, G. Bruni, M. Bruschi, N. Bruscino, L. Bryngemark, T. Buanes, Q. Buat, P. Buchholz, A. G. Buckley, I. A. Budagov, M. K. Bugge, O. Bulekov, B. A. Bullard, T. J. Burch, S. Burdin, C. D. Burgard, A. M. Burger, B. Burghgrave, J. T. P. Burr, C. D. Burton, J. C. Burzynski, V. Büscher, P. J. Bussey, J. M. Butler, C. M. Buttar, J. M. Butterworth, W. Buttinger, C. J. Buxo Vazquez, A. R. Buzykaev, G. Cabras, S. Cabrera Urbán, D. Caforio, H. Cai, V. M. M. Cairo, O. Cakir, N. Calace, P. Calafiura, G. Calderini, P. Calfayan, G. Callea, L. P. Caloba, A. Caltabiano, S. Calvente Lopez, D. Calvet, S. Calvet, T. P. Calvet, M. Calvetti, R. Camacho Toro, S. Camarda, D. Camarero Munoz, P. Camarri, M. T. Camerlingo, D. Cameron, C. Camincher, M. Campanelli, A. Camplani, V. Canale, A. Canesse, M. Cano Bret, J. Cantero, Y. Cao, M. Capua, A. Carbone, R. Cardarelli, F. Cardillo, T. Carli, G. Carlino, B. T. Carlson, E. M. Carlson, L. Carminati, M. Carnesale, R. M. D. Carney, S. Caron, E. Carquin, S. Carrá, G. Carratta, J. W. S. Carter, T. M. Carter, D. Casadei, M. P. Casado, A. F. Casha, E. G. Castiglia, F. L. Castillo, L. Castillo Garcia, V. Castillo Gimenez, N. F. Castro, A. Catinaccio, J. R. Catmore, A. Cattai, V. Cavaliere, N. Cavalli, V. Cavasinni, E. Celebi, F. Celli, K. Cerny, A. S. Cerqueira, A. Cerri, L. Cerrito, F. Cerutti, A. Cervelli, S. A. Cetin, Z. Chadi, D. Chakraborty, M. Chala, J. Chan, W. S. Chan, W. Y. Chan, J. D. Chapman, B. Chargeishvili, D. G. Charlton, T. P. Charman, M. Chatterjee, C. C. Chau, S. Chekanov, S. V. Chekulaev, G. A. Chelkov, A. Chen, B. Chen, C. Chen, C. H. Chen, H. Chen, J. Chen, S. Chen, S. J. Chen, X. Chen, Y. Chen, Y-H. Chen, C. L. Cheng, H. C. Cheng, H. J. Cheng, A. Cheplakov, E. Cheremushkina, R. Cherkaoui El Moursli, E. Cheu, K. Cheung, L. Chevalier, V. Chiarella, G. Chiarelli, G. Chiodini, A. S. Chisholm, A. Chitan, I. Chiu, Y. H. Chiu, M. V. Chizhov, K. Choi, A. R. Chomont, Y. Chou, E. Y. S. Chow, L. D. Christopher, M. C. Chu, X. Chu, J. Chudoba, J. J. Chwastowski, D. Cieri, K. M. Ciesla, V. Cindro, I. A. Cioară, A. Ciocio, F. Cirotto, Z. H. Citron, M. Citterio, D. A. Ciubotaru, B. M. Ciungu, A. Clark, P. J. Clark, J. M. Clavijo Columbie, S. E. Clawson, C. Clement, L. Clissa, Y. Coadou, M. Cobal, A. Coccaro, J. Cochran, R. F. Coelho Barrue, R. Coelho Lopes De Sa, S. Coelli, H. Cohen, A. E. C. Coimbra, B. Cole, J. Collot, P. Conde Muiño, S. H. Connell, I. A. Connelly, E. I. Conroy, F. Conventi, H. G. Cooke, A. M. Cooper-Sarkar, F. Cormier, L. D. Corpe, M. Corradi, E. E. Corrigan, F. Corriveau, M. J. Costa, F. Costanza, D. Costanzo, B. M. Cote, G. Cowan, J. W. Cowley, J. Crane, K. Cranmer, R. A. Creager, S. Crépé-Renaudin, F. Crescioli, M. Cristinziani, M. Cristoforetti, V. Croft, G. Crosetti, A. Cueto, T. Cuhadar Donszelmann, H. Cui, A. R. Cukierman, W. R. Cunningham, S. Czekierda, P. Czodrowski, M. M. Czurylo, M. J. Da Cunha Sargedas De Sousa, J. V. Da Fonseca Pinto, C. Da Via, W. Dabrowski, T. Dado, S. Dahbi, T. Dai, C. Dallapiccola, M. Dam, G. D’amen, V. D’Amico, J. Damp, J. R. Dandoy, M. F. Daneri, M. Danninger, V. Dao, G. Darbo, S. Darmora, A. Dattagupta, S. D’Auria, C. David, T. Davidek, D. R. Davis, B. Davis-Purcell, I. Dawson, K. De, R. De Asmundis, M. De Beurs, S. De Castro, N. De Groot, P. de Jong, H. De la Torre, A. De Maria, D. De Pedis, A. De Salvo, U. De Sanctis, M. De Santis, A. De Santo, J. B. De Vivie De Regie, D. V. Dedovich, J. Degens, A. M. Deiana, J. Del Peso, Y. Delabat Diaz, F. Deliot, C. M. Delitzsch, M. Della Pietra, D. Della Volpe, A. Dell’Acqua, L. Dell’Asta, M. Delmastro, P. A. Delsart, S. Demers, M. Demichev, S. P. Denisov, L. D’Eramo, D. Derendarz, J. E. Derkaoui, F. Derue, P. Dervan, K. Desch, K. Dette, C. Deutsch, P. O. Deviveiros, F. A. Di Bello, A. Di Ciaccio, L. Di Ciaccio, C. Di Donato, A. Di Girolamo, G. Di Gregorio, A. Di Luca, B. Di Micco, R. Di Nardo, C. Diaconu, F. A. Dias, T. Dias Do Vale, M. A. Diaz, F. G. Diaz Capriles, J. Dickinson, M. Didenko, E. B. Diehl, J. Dietrich, S. Díez Cornell, C. Diez Pardos, A. Dimitrievska, W. Ding, J. Dingfelder, I-M. Dinu, S. J. Dittmeier, F. Dittus, F. Djama, T. Djobava, J. I. Djuvsland, M. A. B. Do Vale, D. Dodsworth, C. Doglioni, J. Dolejsi, Z. Dolezal, M. Donadelli, B. Dong, J. Donini, A. D’Onofrio, M. D’Onofrio, J. Dopke, A. Doria, M. T. Dova, A. T. Doyle, E. Drechsler, E. Dreyer, T. Dreyer, A. S. Drobac, D. Du, T. A. du Pree, F. Dubinin, M. Dubovsky, A. Dubreuil, E. Duchovni, G. 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Shatalov, K. Shaw, S. M. Shaw, P. Sherwood, L. Shi, C. O. Shimmin, Y. Shimogama, J. D. Shinner, I. P. J. Shipsey, S. Shirabe, M. Shiyakova, J. Shlomi, M. J. Shochet, J. Shojaii, D. R. Shope, S. Shrestha, E. M. Shrif, M. J. Shroff, E. Shulga, P. Sicho, A. M. Sickles, E. Sideras Haddad, O. Sidiropoulou, A. Sidoti, F. Siegert, Dj. Sijacki, M. V. Silva Oliveira, S. B. Silverstein, S. Simion, R. Simoniello, S. Simsek, P. Sinervo, V. Sinetckii, S. Singh, S. Sinha, M. Sioli, I. Siral, S. Yu. Sivoklokov, J. Sjölin, A. Skaf, E. Skorda, P. Skubic, M. Slawinska, K. Sliwa, V. Smakhtin, B. H. Smart, J. Smiesko, S. Yu. Smirnov, Y. Smirnov, L. N. Smirnova, O. Smirnova, E. A. Smith, H. A. Smith, M. Smizanska, K. Smolek, A. Smykiewicz, A. A. Snesarev, H. L. Snoek, S. Snyder, R. Sobie, A. Soffer, F. Sohns, C. A. Solans Sanchez, E. Yu. Soldatov, U. Soldevila, A. A. Solodkov, S. Solomon, A. Soloshenko, O. V. Solovyanov, V. Solovyev, P. Sommer, H. Son, A. Sonay, W. Y. Song, A. Sopczak, A. L. Sopio, F. Sopkova, S. Sottocornola, R. Soualah, Z. Soumaimi, D. South, S. Spagnolo, M. Spalla, M. Spangenberg, F. Spanò, D. Sperlich, T. M. Spieker, G. Spigo, M. Spina, D. P. Spiteri, M. Spousta, A. Stabile, R. Stamen, M. Stamenkovic, A. Stampekis, M. Standke, E. Stanecka, B. Stanislaus, M. M. Stanitzki, M. Stankaityte, B. Stapf, E. A. Starchenko, G. H. Stark, J. Stark, D. M. Starko, P. Staroba, P. Starovoitov, S. Stärz, R. Staszewski, G. Stavropoulos, P. Steinberg, A. L. Steinhebel, B. Stelzer, H. J. Stelzer, O. Stelzer-Chilton, H. Stenzel, T. J. Stevenson, G. A. Stewart, M. C. Stockton, G. Stoicea, M. Stolarski, S. Stonjek, A. Straessner, J. Strandberg, S. Strandberg, M. Strauss, T. Strebler, P. Strizenec, R. Ströhmer, D. M. Strom, L. R. Strom, R. Stroynowski, A. Strubig, S. A. Stucci, B. Stugu, J. Stupak, N. A. Styles, D. Su, S. Su, W. Su, X. Su, N. B. Suarez, K. Sugizaki, V. V. Sulin, M. J. Sullivan, D. M. S. Sultan, S. Sultansoy, T. Sumida, S. Sun, X. Sun, O. Sunneborn Gudnadottir, C. J. E. Suster, M. R. Sutton, M. Svatos, M. Swiatlowski, T. Swirski, I. Sykora, M. Sykora, T. Sykora, D. Ta, K. Tackmann, A. Taffard, R. Tafirout, E. Tagiev, R. H. M. Taibah, R. Takashima, K. Takeda, T. Takeshita, E. P. Takeva, Y. Takubo, M. Talby, A. A. Talyshev, K. C. Tam, N. M. Tamir, A. Tanaka, J. Tanaka, R. Tanaka, Z. Tao, S. Tapia Araya, S. Tapprogge, A. Tarek Abouelfadl Mohamed, S. Tarem, K. Tariq, G. Tarna, G. F. Tartarelli, P. Tas, M. Tasevsky, E. Tassi, G. Tateno, Y. Tayalati, G. N. Taylor, W. Taylor, H. Teagle, A. S. Tee, R. Teixeira De Lima, P. Teixeira-Dias, H. Ten Kate, J. J. Teoh, K. Terashi, J. Terron, S. Terzo, M. Testa, R. J. Teuscher, N. Themistokleous, T. Theveneaux-Pelzer, O. Thielmann, D. W. Thomas, J. P. Thomas, E. A. Thompson, P. D. Thompson, E. Thomson, E. J. Thorpe, Y. Tian, V. Tikhomirov, Yu. A. Tikhonov, S. Timoshenko, P. Tipton, S. Tisserant, S. H. Tlou, A. Tnourji, K. Todome, S. Todorova-Nova, S. Todt, M. Togawa, J. Tojo, S. Tokár, K. Tokushuku, E. Tolley, R. Tombs, M. Tomoto, L. Tompkins, P. Tornambe, E. Torrence, H. Torres, E. Torró Pastor, M. Toscani, C. Tosciri, J. Toth, D. R. Tovey, A. Traeet, C. J. Treado, T. Trefzger, A. Tricoli, I. M. Trigger, S. Trincaz-Duvoid, D. A. Trischuk, B. Trocmé, A. Trofymov, C. Troncon, F. Trovato, L. Truong, M. Trzebinski, A. Trzupek, F. Tsai, A. Tsiamis, P. V. Tsiareshka, A. Tsirigotis, V. Tsiskaridze, E. G. Tskhadadze, M. Tsopoulou, I. I. Tsukerman, V. Tsulaia, S. Tsuno, O. Tsur, D. Tsybychev, Y. Tu, A. Tudorache, V. Tudorache, A. N. Tuna, S. Turchikhin, D. Turgeman, I. Turk Cakir, R. J. Turner, R. Turra, P. M. Tuts, S. Tzamarias, P. Tzanis, E. Tzovara, K. Uchida, F. Ukegawa, G. Unal, M. Unal, A. Undrus, G. Unel, F. C. Ungaro, K. Uno, J. Urban, P. Urquijo, G. Usai, R. Ushioda, M. Usman, Z. Uysal, V. Vacek, B. Vachon, K. O. H. Vadla, T. Vafeiadis, C. Valderanis, E. Valdes Santurio, M. Valente, S. Valentinetti, A. Valero, L. Valéry, R. A. Vallance, A. Vallier, J. A. Valls Ferrer, T. R. Van Daalen, P. Van Gemmeren, S. Van Stroud, I. Van Vulpen, M. Vanadia, W. Vandelli, M. Vandenbroucke, E. R. Vandewall, D. Vannicola, L. Vannoli, R. Vari, E. W. Varnes, C. Varni, T. Varol, D. Varouchas, K. E. Varvell, M. E. Vasile, L. Vaslin, G. A. Vasquez, F. Vazeille, D. Vazquez Furelos, T. Vazquez Schroeder, J. Veatch, V. Vecchio, M. J. Veen, I. Veliscek, L. M. Veloce, F. Veloso, S. Veneziano, A. Ventura, A. Verbytskyi, M. Verducci, C. Vergis, M. Verissimo De Araujo, W. Verkerke, A. T. Vermeulen, J. C. Vermeulen, C. Vernieri, P. J. Verschuuren, M. L. Vesterbacka, M. C. Vetterli, N. Viaux Maira, T. Vickey, O. E. Vickey Boeriu, G. H. A. Viehhauser, L. Vigani, M. Villa, M. Villaplana Perez, E. M. Villhauer, E. Vilucchi, M. G. Vincter, G. S. Virdee, A. Vishwakarma, C. Vittori, I. Vivarelli, V. Vladimirov, E. Voevodina, M. Vogel, P. Vokac, J. Von Ahnen, S. E. von Buddenbrock, E. Von Toerne, V. Vorobel, K. Vorobev, M. Vos, J. H. Vossebeld, M. Vozak, L. Vozdecky, N. Vranjes, M. Vranjes Milosavljevic, V. Vrba, M. Vreeswijk, R. Vuillermet, I. Vukotic, S. Wada, C. Wagner, P. Wagner, W. Wagner, S. Wahdan, H. Wahlberg, R. Wakasa, M. Wakida, V. M. Walbrecht, J. Walder, R. Walker, S. D. Walker, W. Walkowiak, A. M. Wang, A. Z. Wang, C. Wang, H. Wang, J. Wang, P. Wang, R.-J. Wang, R. Wang, S. M. Wang, S. Wang, T. Wang, W. T. Wang, W. X. Wang, X. Wang, Y. Wang, Z. Wang, A. Warburton, C. P. Ward, R. J. Ward, N. Warrack, A. T. Watson, M. F. Watson, G. Watts, B. M. Waugh, A. F. Webb, C. Weber, M. S. Weber, S. A. Weber, S. M. Weber, C. Wei, Y. Wei, A. R. Weidberg, J. Weingarten, M. Weirich, C. Weiser, T. Wenaus, B. Wendland, T. Wengler, S. Wenig, N. Wermes, M. Wessels, K. Whalen, A. M. Wharton, A. S. White, A. White, M. J. White, D. Whiteson, W. Wiedenmann, C. Wiel, M. Wielers, N. Wieseotte, C. Wiglesworth, L. A. M. Wiik-Fuchs, D. J. Wilbern, H. G. Wilkens, L. J. Wilkins, D. M. Williams, H. H. Williams, S. Williams, S. Willocq, P. J. Windischhofer, I. Wingerter-Seez, F. Winklmeier, B. T. Winter, M. Wittgen, M. Wobisch, A. Wolf, R. Wölker, J. Wollrath, M. W. Wolter, H. Wolters, V. W. S. Wong, A. F. Wongel, S. D. Worm, B. K. Wosiek, K. W. Woźniak, K. Wraight, J. Wu, S. L. Wu, X. Wu, Y. Wu, Z. Wu, J. Wuerzinger, T. R. Wyatt, B. M. Wynne, S. Xella, J. Xiang, X. Xiao, X. Xie, I. Xiotidis, D. Xu, H. Xu, L. Xu, R. Xu, T. Xu, W. Xu, Y. Xu, Z. Xu, B. Yabsley, S. Yacoob, N. Yamaguchi, Y. Yamaguchi, M. Yamatani, H. Yamauchi, T. Yamazaki, Y. Yamazaki, J. Yan, Z. Yan, H. J. Yang, H. T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, Z. Yang, W-M. Yao, Y. C. Yap, H. Ye, J. Ye, S. Ye, I. Yeletskikh, M. R. Yexley, P. Yin, K. Yorita, K. Yoshihara, C. J. S. Young, C. Young, R. Yuan, X. Yue, M. Zaazoua, B. Zabinski, G. Zacharis, E. Zaffaroni, T. Zakareishvili, N. Zakharchuk, S. Zambito, D. Zanzi, S. V. Zeißner, C. Zeitnitz, G. Zemaityte, J. C. Zeng, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, M. Zgubič, B. Zhang, D. F. Zhang, G. Zhang, J. Zhang, K. Zhang, L. Zhang, M. Zhang, R. Zhang, S. Zhang, X. Zhang, Z. Zhang, P. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, Z. Zheng, D. Zhong, B. Zhou, C. Zhou, H. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, C. Zhu, H. L. Zhu, H. Zhu, J. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, V. Zhulanov, D. Zieminska, N. I. Zimine, S. Zimmermann, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T. G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
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Vector-Like Quarks ,Beyond Standard Model ,Exotics ,Hadron-Hadron Scattering ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract A search is presented for single production of a vector-like B quark decaying into a Standard Model b-quark and a Standard Model Higgs boson, which decays into a b b ¯ $$ b\overline{b} $$ pair. The search is carried out in 139 fb −1 of s $$ \sqrt{s} $$ = 13 TeV proton-proton collision data collected by the ATLAS detector at the LHC between 2015 and 2018. No significant deviation from the Standard Model background prediction is observed, and mass-dependent exclusion limits at the 95% confidence level are set on the resonance production cross-section in several theoretical scenarios determined by the couplings c W , c Z and c H between the B quark and the Standard Model W, Z and Higgs bosons, respectively. For a vector-like B occurring as an isospin singlet, the search excludes values of c W greater than 0.45 for a B resonance mass (m B ) between 1.0 and 1.2 TeV. For 1.2 TeV < m B < 2.0 TeV, c W values larger than 0.50–0.65 are excluded. If the B occurs as part of a (B, Y) doublet, the smallest excluded c Z coupling values range between 0.3 and 0.5 across the investigated resonance mass range 1.0 TeV < m B < 2.0 TeV.
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- 2023
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127. Early diagnosis of aortic calcification through dental X-ray examination for dental pulp stones
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Misao Ishikawa, Hiroyuki Kanzaki, Ryo Kodera, Takehiro Sekimizu, Satoshi Wada, Syunnosuke Tohyama, Tomomi Ida, Miho Shimoyama, Shugo Manase, Hiroshi Tomonari, and Noriyuki Kuroda
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Medicine ,Science - Abstract
Abstract Vascular calcification, an ectopic calcification exacerbated by aging and renal dysfunction, is closely associated with cardiovascular disease. However, early detection indicators are limited. This study focused on dental pulp stones, ectopic calcifications found in oral tissues that are easily identifiable on dental radiographs. Our investigation explored the frequency and timing of these calcifications in different locations and their relationship to aortic calcification. In cadavers, we examined the association between the frequency of dental pulp stones and aortic calcification, revealing a significant association. Notably, dental pulp stones appeared prior to aortic calcification. Using a rat model of hyperphosphatemia, we confirmed that dental pulp stones formed earlier than calcification in the aortic arch. Interestingly, there were very few instances of aortic calcification without dental pulp stones. Additionally, we conducted cell culture experiments with vascular smooth muscle cells (SMCs) and dental pulp cells (DPCs) to explore the regulatory mechanism underlying high phosphate-mediated calcification. We found that DPCs produced calcification deposits more rapidly and exhibited a stronger augmentation of osteoblast differentiation markers compared with SMCs. In conclusion, the observation of dental pulp stones through X-ray examination during dental checkups could be a valuable method for early diagnosis of aortic calcification risk.
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- 2023
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128. Helicity amplitudes without gauge cancellation for electroweak processes
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Junmou Chen, Kaoru Hagiwara, Junichi Kanzaki, and Kentarou Mawatari
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Astrophysics ,QB460-466 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract In the 5-component representation of weak bosons, the first four components make a Lorentz four vector, representing the transverse and longitudinal polarizations excluding the scalar component of the weak bosons, whereas its fifth component corresponds to the Goldstone boson. We obtain the $$5\times 5$$ 5 × 5 component propagators of off-shell weak bosons, proposed previously and named after the Goldstone boson equivalence theorem, by starting from the unitary-gauge representation of the tree-level scattering amplitudes, and by applying the BRST (Becchi–Rouet–Stora–Tyutin) identities to the two sub-amplitudes connected by each off-shell weak-boson line. By replacing all weak boson vertices with those among the off-shell 5-component wavefunctions, we arrive at the expression of the electroweak scattering amplitudes, where the magnitude of each Feynman amplitude has the correct on-shell limits for all internal propagators, and hence with no artificial gauge cancellation among diagrams. Although our derivation is limited to the tree-level only, it allows us to study the properties of each Feynman amplitude separately, and then learn how they interfere in the full amplitudes. We implement the 5-component weak boson propagators and their vertices in the numerical helicity amplitude calculation code HELAS (Helicity Amplitude Subroutines), so that an automatic amplitude generation program such as MadGraph can generate the scattering amplitudes without gauge cancellation. We present results for several high-energy scattering processes where subtle gauge-theory cancellation among diagrams takes place in all the other known approaches.
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- 2023
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129. Association between complete revascularization of the coronary artery and clinical outcomes in peripheral artery disease: a sub-analysis of the I-PAD Nagano registry
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Kato, Tamon, Ueki, Yasushi, Minamisawa, Masatoshi, Miura, Takashi, Oyama, Yushi, Hashizume, Naoto, Yokota, Daisuke, Taki, Minami, Senda, Keisuke, Okina, Yoshiteru, Wakabayashi, Tadamasa, Fujimori, Koki, Karube, Kenichi, Sakai, Takahiro, Nomi, Hidetomo, Yui, Hisanori, Kanzaki, Yusuke, Machida, Keisuke, Maruyama, Shusaku, Nagae, Ayumu, Saigusa, Tatsuya, Ebisawa, Soichiro, Okada, Ayako, Motoki, Hirohiko, and Kuwahara, Koichiro
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- 2023
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130. A factor for predicting simultaneous internal limiting membrane peeling during epiretinal membrane removal: swept-source optical coherence tomography-based evaluation of epiretinal membrane adhesion to the retina
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Matoba, Ryo, Kanzaki, Yuki, Kimura, Shuhei, Hosokawa, Mio M., Shiode, Yusuke, Morita, Tetsuro, and Morizane, Yuki
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- 2023
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131. Applications of machine learning in surge prediction for vehicle turbochargers
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Saito, Hiroki, Kanzaki, Dai, and Yonekura, Kazuo
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- 2024
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132. Correlation Between Contrast-Detail Analysis and Clinical Image Quality Assessment of Intrapulmonary Lesions in Dual-Energy Subtraction Chest Radiography Using the Two-Shot Method: A Phantom Study
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Kuramoto, Taku, Takarabe, Shinya, Kanzaki, Yui, Shibayama, Yusuke, Yamasaki, Yuzo, and Kitamura, Yoshiyuki
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- 2024
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133. Distal junctional failure after corrective surgery without pelvic fixation for thoracolumbar junctional kyphosis due to osteoporotic vertebral fracture
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Kudo, Yoshifumi, Okano, Ichiro, Toyone, Tomoaki, Kanzaki, Koji, Segami, Kazuyuki, Kawamura, Naohiro, Sekimizu, Masaya, Maruyama, Hiroshi, Yamamura, Ryo, Hayakawa, Chikara, Tsuchiya, Koki, Tani, Soji, Ishikawa, Koji, and Inagaki, Katsunori
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- 2024
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134. Injuries to both anterolateral ligament and Kaplan fiber of the iliotibial band do not increase preoperative pivot-shift phenomenon in ACL injury
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Tokura, Takeo, Nagai, Kanto, Hoshino, Yuichi, Watanabe, Shu, Kanzaki, Noriyuki, Nishida, Kyohei, Matsushita, Takehiko, and Kuroda, Ryosuke
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- 2024
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135. How can design help enhance trust calibration in public autonomous vehicles?
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Klebanov, Yuri, Mikulinsky, Romi, Reznikov, Tom, Pennington, Miles, Suda, Yoshihiro, Hiraoka, Toshihiro, and Kanzaki, Shoichi
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Computer Science - Human-Computer Interaction - Abstract
Trust is a multilayered concept with critical relevance when it comes to introducing new technologies. Understanding how humans will interact with complex vehicle systems and preparing for the functional, societal and psychological aspects of autonomous vehicles' entry into our cities is a pressing concern. Design tools can help calibrate the adequate and affordable level of trust needed for a safe and positive experience. This study focuses on passenger interactions capable of enhancing the system trustworthiness and data accuracy in future shared public transportation., Comment: 4 pages, 5 figures, IV 2021 Nagoya, Trust Calibration Workshop
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- 2021
136. Activation of Nuclear Factor Erythroid 2-Related Factor 2 Transcriptionally Upregulates Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Expression and Inhibits Ectopic Calcification in Mice
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Ida Tomomi, Hiroyuki Kanzaki, Miho Shimoyama, Syunnosuke Tohyama, Misao Ishikawa, Yuta Katsumata, Chihiro Arai, Satoshi Wada, Shugo Manase, and Hiroshi Tomonari
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ectopic calcification ,Nrf2 ,pyrophosphate (PPi) ,osteoblastic differentiation ,ENPP1 ,anti-oxidation ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Calcification plays a key role in biological processes, and breakdown of the regulatory mechanism results in a pathological state such as ectopic calcification. We hypothesized that ENPP1, the enzyme that produces the calcification inhibitor pyrophosphate, is transcriptionally regulated by Nrf2, and that Nrf2 activation augments ENPP1 expression to inhibit ectopic calcification. Cell culture experiments were performed using mouse osteoblastic cell line MC3T3-E1. Nrf2 was activated by 5-aminolevulinic acid and sodium ferrous citrate. Nrf2 overexpression was induced by the transient transfection of an Nrf2 expression plasmid. ENPP1 expression was monitored by real-time RT-PCR. Because the promoter region of ENPP1 contains several Nrf2-binding sites, chromatin immunoprecipitation using an anti-Nrf2 antibody followed by real-time PCR (ChIP-qPCR) was performed. The relationship between Nrf2 activation and osteoblastic differentiation was examined by alkaline phosphatase (ALP) and Alizarin red staining. We used mice with a hypomorphic mutation in ENPP1 (ttw mice) to analyze whether Nrf2 activation inhibits ectopic calcification. Nrf2 and Nrf2 overexpression augmented ENPP1 expression and inhibited osteoblastic differentiation, as indicated by ALP expression and calcium deposits. ChIP-qPCR showed that some putative Nrf2-binding sites in the ENPP1 promoter region were bound by Nrf2. Nrf2 activation inhibited ectopic calcification in mice. ENPP1 gene expression was transcriptionally regulated by Nrf2, and Nrf2 activation augmented ENPP1 expression, leading to the attenuation of osteoblastic differentiation and ectopic calcification in vitro and in vivo. Nrf2 activation has a therapeutic potential for preventing ectopic calcification.
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- 2024
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137. Malleable APGAS Programs and Their Support in Batch Job Schedulers.
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Patrick Finnerty, Leo Takaoka, Takuma Kanzaki, and Jonas Posner
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- 2023
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138. Gas-phase odor mixture quantification based on relative comparison method using multiple olfactory receptors
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Deng, Hongchao, Mitsuno, Hidefumi, Kuroda, Eri, Niki, Sawako, Kanzaki, Ryohei, and Nakamoto, Takamichi
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- 2024
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139. Implications of ventricular arrhythmia after cardiac resynchronization therapy
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Ueda, Nobuhiko, Ishibashi, Kohei, Noda, Takashi, Oka, Satoshi, Miyazaki, Yuichiro, Shimamoto, Keiko, Wakamiya, Akinori, Nakajima, Kenzaburo, Kamakura, Tsukasa, Wada, Mitsuru, Inoue, Yuko, Miyamoto, Koji, Nagase, Satoshi, Aiba, Takeshi, Kanzaki, Hideaki, Izumi, Chisato, Noguchi, Teruo, and Kusano, Kengo
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- 2024
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140. Computational complexity of jumping block puzzles
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Kanzaki, Masaaki, Otachi, Yota, Viglietta, Giovanni, and Uehara, Ryuhei
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- 2024
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141. Clinical outcomes of arthroscopic lateral ligament repair using a knotless anchor for chronic lateral ankle instability
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Shimabukuro, Masashi, Hoshino, Yuichi, Kanzaki, Noriyuki, Kataoka, Kiminari, Yamamoto, Tetsuya, Nukuto, Koji, Nishida, Kyohei, Nagai, Kanto, Matsushita, Takehiko, and Kuroda, Ryosuke
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- 2024
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142. Changes in epicardial adipose tissue volume before and after cryoballoon ablation in patients with atrial fibrillation: Supporting the “AF begets EAT” theory
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Shimojo, Kazuki, Morishima, Itsuro, Morita, Yasuhiro, Kanzaki, Yasunori, Watanabe, Naoki, Yoshioka, Naoki, Shibata, Naoki, Arao, Yoshihito, Ohi, Takuma, Goto, Hiroki, Karasawa, Hoshito, Nakagawa, Yuta, Kawasaki, Yuki, and Yoshie, Tatsuki
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- 2024
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143. Prognostic Predictors of Tricuspid Regurgitation Worsening after Mitral Regurgitation Surgery with Mild Tricuspid Regurgitation
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Hada, Tasuku, Amano, Masashi, Murata, Shunsuke, Nishimura, Kunihiro, Nakagawa, Shoko, Irie, Yuki, Moriuchi, Kenji, Okada, Atsushi, Kitai, Takeshi, Amaki, Makoto, Kanzaki, Hideaki, Fukushima, Satsuki, Kusano, Kengo, Noguchi, Teruo, Fujita, Tomoyuki, and Izumi, Chisato
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- 2024
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144. Usefulness of exercise stress echocardiography for predicting cardiovascular events and atrial fibrillation in hypertrophic cardiomyopathy
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Yoshii, Tomohiro, Amano, Masashi, Moriuchi, Kenji, Nakagawa, Shoko, Nishimura, Hitomi, Tamai, Yurie, Mizumoto, Ayaka, Koda, Aiko, Demura, Yutaka, Jo, Yoshito, Irie, Yuki, Sakamoto, Takahiro, Amaki, Makoto, Kanzaki, Hideaki, Noguchi, Teruo, Nishimura, Kunihiro, Kitai, Takeshi, and Izumi, Chisato
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- 2024
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145. The Search for Risk, Diagnostic, and Prognostic Biomarkers of Cholangiocarcinoma and Their Biological and Clinicopathologic Significance
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Macias, Rocio I.R., Kanzaki, Hiroaki, Berasain, Carmen, Avila, Matias A., Marin, Jose J.G., and Hoshida, Yujin
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- 2024
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146. The distribution and dynamics of residual mercury from the Chisso chemical plant in sediments of the Yatsushiro Sea, western Kyushu, Japan: have recent sedimentations lowered surface mercury concentrations?
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Tomiyasu, Takashi, Shitauchi, Ryohei, Kasai, Daigo, Kitagawa, Toshiki, Kodamatani, Hitoshi, and Kanzaki, Ryo
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- 2023
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147. Clinical application of artificial intelligence algorithm for prediction of one-year mortality in heart failure patients
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Takahama, Hiroyuki, Nishimura, Kunihiro, Ahsan, Budrul, Hamatani, Yasuhiro, Makino, Yuichi, Nakagawa, Shoko, Irie, Yuki, Moriuchi, Kenji, Amano, Masashi, Okada, Atsushi, Kitai, Takeshi, Amaki, Makoto, Kanzaki, Hideaki, Noguchi, Teruo, Kusano, Kengo, Akao, Masaharu, Yasuda, Satoshi, and Izumi, Chisato
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- 2023
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148. Improving the efficiency of identifying malignant pulmonary nodules before surgery via a combination of artificial intelligence CT image recognition and serum autoantibodies
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Ding, Yu, Zhang, Jingyu, Zhuang, Weitao, Gao, Zhen, Kuang, Kaiming, Tian, Dan, Deng, Cheng, Wu, Hansheng, Chen, Rixin, Lu, Guojie, Chen, Gang, Mendogni, Paolo, Migliore, Marcello, Kang, Min-Woong, Kanzaki, Ryu, Tang, Yong, Yang, Jiancheng, Shi, Qiuling, and Qiao, Guibin
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- 2023
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149. Excimer laser coronary angioplasty versus manual aspiration thrombectomy in patients with ST-segment elevation myocardial infarction: analyzed by nuclear scintigraphy
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Shimojo, Kazuki, Shibata, Naoki, Takagi, Kensuke, Mitsuhashi, Hirotsugu, Morita, Yasuhiro, Kanzaki, Yasunori, Watanabe, Naoki, Yoshioka, Naoki, Miyazawa, Hiroyuki, Imaoka, Takuro, Sakamoto, Gaku, Ohi, Takuma, Goto, Hiroki, Karasawa, Hoshito, and Morishima, Itsuro
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- 2023
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150. A Case of Young Obese Heart Failure Patient Using Multidisciplinary Treatment Centered on the Fantastic Four Improved Cardio Ankle Vascular Index and Cardiac Function
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Ikeda Y, Iwakawa M, Kiyokawa H, Nakagami T, Kanzaki S, Ogawa A, Tabata T, Takahashi M, Kinoshita T, and Shimizu K
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obesity ,hypertension ,obstructive sleep apnea ,arterial stiffness ,cardio ankle vascular index ,Medicine (General) ,R5-920 - Abstract
Yuki Ikeda,1 Masahiro Iwakawa,1 Hajime Kiyokawa,1 Takahiro Nakagami,1 Shinya Kanzaki,2 Akihiro Ogawa,2 Tsuyoshi Tabata,3 Mao Takahashi,1 Toshio Kinoshita,1,3 Kazuhiro Shimizu1 1Department of Internal Medicine, Toho University Sakura Medical Center, Chiba, Japan; 2Department of Rehabilitation, Toho University Sakura Medical Center, Chiba, Japan; 3Department of Clinical Functional Physiology, Toho University Sakura Medical Center, Chiba, JapanCorrespondence: Kazuhiro Shimizu, Department of Internal Medicine, Toho University Sakura Medical Center, Chiba, Japan, Tel +81-43-462-8811, Fax +81-43-462-8820, Email k432@sakura.medtoho-u.ac.jpAbstract: Obesity-induced heart failure (HF) in young people is a serious problem. The treatments for HF have developed in recent years. The following four basic HF drugs have been widely recognized as the “Fantastic Four”: beta-adrenergic blocking agents, mineralocorticoid receptor antagonists (MRA), sodium glucose transporter 2 inhibitors (SGLT2 inhibitors), and angiotensin receptor neprilysin inhibitors (ARNI). However, the interaction between the heart and blood vessels has not received much attention. The cardio-ankle vascular index (CAVI) is an arterial stiffness index that is unaffected by blood pressure at the time of measurement. A 34-year-old obese man was admitted with dyspnea and edema. His cardiac function was severely impaired, and CAVI was increased. After administration of multidisciplinary HF treatment centered on the “Fantastic Four”, his cardiac function and CAVI improved dramatically in a short time period. This case suggests the importance of improvement both cardiac and vascular function for the treatment of HF.Keywords: obesity, hypertension, obstructive sleep apnea, arterial stiffness, cardio ankle vascular index
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- 2023
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