101. Adult T-cell leukemia/lymphoma in which the pathohistological diagnosis was identical to that of Ki-1 positive anaplastic large cell lymphoma.
- Author
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Takahara T, Masutani K, Kajiwara E, Sadoshima S, Misago M, Sasaguri Y, and Onoyama K
- Subjects
- Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bone Neoplasms radiotherapy, Bone Neoplasms secondary, DNA, Viral analysis, Diagnosis, Differential, Human T-lymphotropic virus 1 genetics, Humans, Leukemia-Lymphoma, Adult T-Cell drug therapy, Leukemia-Lymphoma, Adult T-Cell virology, Lumbar Vertebrae diagnostic imaging, Lymph Nodes pathology, Lymphoma, Large-Cell, Anaplastic drug therapy, Lymphoma, Large-Cell, Anaplastic virology, Male, Neoplasms, Unknown Primary, Proviruses genetics, Radiography, Remission Induction, Virus Integration, Human T-lymphotropic virus 1 isolation & purification, Ki-1 Antigen analysis, Leukemia-Lymphoma, Adult T-Cell pathology, Lymphoma, Large-Cell, Anaplastic pathology, Proviruses isolation & purification
- Abstract
A 65-year-old man developed severe lumbago and a loss of appetite two months before presentation. A computerized tomograph at admission revealed soft tissue masses destroying the Th12, L4 and L5 vertebral bones. We diagnosed the lesions to be metastatic bone tumors, but the primary focus could not be determined. Just after the irradiation treatment, abnormal lymphocytes were detected in the peripheral blood cells. Under the suspicion of adult T-cell leukemia/ lymphoma (ATL), we thus performed a lymph node biopsy. The specimens were histologically composed of Ki-1 positive anaplastic large cell lymphoma (ALCL). The lymphoma cells demonstrated a biclonal integration of HTLV-1 proviral DNA. After 6 cycles of chemotherapy, the patient has demonstrated a partial and favorable remission from ATL.
- Published
- 1999
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