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We outline specific steps that NASA and the space science community can take to advance collaboration and coordination between the communities represented by the four NASA Science Mission Directorate Divisions. It is important to note that the only way that this effort can succeed is if NASA initiates and supports it through directed resources.

We conduct a series of experiments to understand the nature of thrust faulting as a result of global thermal contraction in planetary bodies such as Mercury. The spatial scales and patterns of faulting due to contraction are still not very well understood. However, the problem is complicated even for the homogeneous case where the crustal thickness and material properties do not vary spatially. Previous research showed that the thrust faulting patterns are non-random and are arranged in long systems. This is probably due to the regional-scale stress patterns interacting with each other, leading to the creation of coherent structures. We first conduct 1-Axis experiments where we simulate the contraction of the substratum using an elastic ribbon. On top of this we place the material for which the friction, cohesion and thickness can be controlled for each experiment. The shared interface between the frictional-cohesive material and the shortening elastic substratum dictates undulations and finally the generation of slip planes in the upper layer. We discuss the spatial distribution of these patterns spatially. We then speculate the interaction of such patterns on a 2D plane.

Pit craters are enigmatic sub-circular depressions observed on rocky and icy planetary bodies across the Solar System. These craters do not primarily form during catastrophic impact or the forcible eruption of subsurface materials, but likely due to collapse of subsurface cavities following fluid (e.g., magma) movement and/or extensional tectonics. Pit craters thus provide important surficial records of otherwise inaccessible subsurface processes. However, unlocking these pit crater archives is difficult because we do not know how their surface expression relates to their subsurface structure or driving mechanisms. As such, there is a variety of hypotheses concerning pit crater formation, which variously relate cavity collapse to: (i) opening of dilatational jogs during faulting; (ii) tensile fracturing; (iii) karst development; (iv) permafrost melting; (v) lava tube evacuation; (vi) volatile release from dyke tip process zones; (vii) pressure waning behind a propagating dike tip; (viii) migration of magma away from a reservoir; and/or (ix) hydrothermal fluid movement inducing host rock porosity collapse. Validating whether these proposed mechanisms can drive pit crater formation and, if so, identifying how the physical characteristics of pits can be used to infer their driving mechanisms, is critical to probing subsurface processes on Earth and other planetary bodies.Here we use seismic reflection data from the North Carnarvon Basin offshore NW Australia, which provides ultra-sound like images of Earth’s subsurface, to characterize the subsurface structure of natural pit craters. We extracted geometrical data for 61 pits, and find that they are broadly cylindrical, with some displaying an inverted conical (trumpet-like) morphology at their tops. Fifty-six pit craters, which are sub-circular and have widths of ~150–740 m, extend down ~500 m to and are aligned in chains above the upper tips of dikes; crater depths are ~12–225 m. These dike-related pit craters occur within long, linear graben interpreted to be bound by dyke-induced normal faults. Five pit craters, which are ~140–740 m wide and ~32–107 m deep, formed independent of dykes and are associated only with tectonic normal faults. Our preliminary data reveal a moderate, positive correlation between crater width and depth but there is no distinction between the depth and width trends of pit craters associated with dikes and those with tectonic normal faults. To test whether our quantitative data can be used to inform interpretation of pit craters observed on other planetary bodies, we compare their morphology to those imaged in Noctis Labyrinthus on Mars; there are >200 pit craters here, most of which occur in chains, with widths ranging from 369–11743 m and depths from 1–1858 m.Overall, we show reflection seismology is a powerful tool for studying the three-dimensional geometry of pit craters, with which we can test pit crater formation mechanisms. We anticipate future seismic-based studies will improve our understanding of how the surface expressions of pit craters (either in subaerial or submarine settings) can be used to reconstruct subsurface structures and processes on other planetary bodies, where such subsurface information is not currently available.

Self-medication with antibiotics is a major contributing factor to antimicrobial resistance. Prior research examining factors associated with antibiotic self-medication has focused on an individual’s knowledge about antibiotics, antibiotic usage practices, accessibility to antibiotic medication, and demographic characteristics. The role of psychological distress associated with perceived health risks in explaining antibiotic self-medication is less understood. This study was designed to address this knowledge gap in the context of the COVID-19 pandemic in Australia. An online survey of 2217 participants was conducted at the height of the initial outbreak and revealed that 19.5% of participants took antibiotics to protect themselves from COVID-19. Multivariate logistic analysis examined the predictors of taking antibiotics for protection against COVID-19. An integrative framework developed from the results illustrates potential pathways and facilitating factors that may contribute to prophylactic self-medication with antibiotics. Specifically, COVID-19 pandemic-induced psychological distress was significantly positively related to self-medication. Preventive use of antibiotics was also facilitated by a lack of understanding about antibiotics, inappropriate antibiotics usage practices, the nature of the patient-doctor relationship, and demographic characteristics. The findings highlight that to combat antimicrobial resistance due to self-medication, interventions need to focus on interrupting entrenched behavioural responses and addressing emotional responses to perceived health risks.

Over the past several decades, thousands of planets have been discovered outside of our Solar System. These planets exhibit enormous diversity, and their large numbers provide a statistical opportunity to place our Solar System within the broader context of planetary structure, atmospheres, architectures, formation, and evolution. Meanwhile, the field of exoplanetary science is rapidly forging onward towards a goal of atmospheric characterization, inferring surface conditions and interiors, and assessing the potential for habitability. However, the interpretation of exoplanet data requires the development and validation of exoplanet models that depend on in-situ data that, in the foreseeable future, are only obtainable from our Solar System. Thus, planetary and exoplanetary science would both greatly benefit from a symbiotic relationship with a two-way flow of information. Here, we describe the critical lessons and outstanding questions from planetary science, the study of which are essential for addressing fundamental aspects for a variety of exoplanetary topics. We outline these lessons and questions for the major categories of Solar System bodies, including the terrestrial planets, the giant planets, moons, and minor bodies. We provide a discussion of how many of these planetary science issues may be translated into exoplanet observables that will yield critical insight into current and future exoplanet discoveries., 53 pages, 5 figures, invited review, accepted for publication in the Journal of Geophysical Research: Planets

Fluvial erosion is usually assumed to be absent on Venus, precluded by a high surface temperature of ~450 °C and supported by extensive uneroded volcanic flows. However, recent global circulation models suggest the possibility of Earth-like climatic conditions on Venus for much of its earlier history, prior to catastrophic runaway greenhouse warming. We observe that the stratigraphically oldest, geologically most complex units, tesserae, exhibit valley patterns morphologically similar to the patterns resulting from fluvial erosion on Earth. Given poor topographic resolution, we use an indirect technique to recognize valleys, based on the pattern of lava flooding of tesserae margins by adjacent plains volcanism. These observed valley patterns are attributed to primary geology, tectonic deformation, followed by fluvial erosion (and lesser wind erosion). This proposed fluvial erosion in tesserae provides support for climate models for a cool, wet climate on early Venus and could be an attractive research theme for future Venus missions., The authors here use Magellan data to interpret geomorphological features on Venus and present a strong hypothesis for fluvial erosion.

Background Interventions to better manage aggressive behaviour and reduce recidivism are a primary concern for corrective services. Nutritional interventions to correct prisoner behaviour have been largely overlooked in the literature. Emerging evidence suggests that dietary intake influences aggressive behaviours and that nutritional supplementation with omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) could attenuate both the severity and frequency of aggressive behaviour. Methods Adult male prisoners who have a history of aggressive behaviour (n = 600) will be recruited from at least 6 Correctional Centres and randomised to receive either n-3 LCPUFA or placebo supplementation for a 16-week duration. Treatment will be with either 1 g/day of n-3 LCPUFA (694 mg DHA and 397 mg EPA) or placebo capsules, which are a corn/soy oil blend and are identical in size and colour. The primary outcome measure is the Inmate Behavioural Observation Scale (IBOS): an objective measure of aggressive behaviour. Secondary outcome measures include questionnaires (including aggression, attention deficit disorder, impulsivity, depression/anxiety/stress scales), engagement in programmes, recidivism and quality of life. Baseline and post-intervention assessments include the IBOS, questionnaires and blood to measure the levels of n-3 LCPUFA. Discussion To conclusively test the potential that increasing n-3 LCPUFA intakes can improve rates of prisoner aggression and associated mental health and violence-related social system management costs, we propose an adequately powered multi-centre, double-blind, randomised controlled trial, examining the effects of n-3 LCPUFA supplementation on aggressive behaviour in adult male prisoners. If successful, this study will inform prisoner policy with respect to nutrition and by inference contribute to a broader community approach to preventative mental health practices. Trial registration Australian New Zealand Clinical Trial Registry (ANZCTR) ACTRN12618001665224. Registered on 10 October 2018.

The physical properties and mechanical behaviour of impactites are an important parameter in fluid flow models and slope stability and landscape evolution assessments for heavily impacted planetary bodies. We first present porosity, permeability, Young's modulus, and uniaxial compressive strength measurements for three suevites from the Ries impact crater (Germany). Porosity ranges from 0.18 to 0.43, permeability from 5.8 × 10−16 to 5.1 × 10−14 m2, Young's modulus from 1.4 to 8.1 GPa, and uniaxial compressive strength from 7.3 to 48.6 MPa. To explore their mechanical behaviour, we performed triaxial deformation experiments on these samples at a range of confining pressures. The brittle–ductile transition for the lowest (0.25) and highest (0.38) porosity suevite samples was at a confining pressure of ~30 and ~10 MPa, respectively (corresponding to, for example, depths of ~1 and ~4 km on Mars, respectively). Microstructural observations show that the dominant deformation micromechanism during brittle deformation is microcracking, and during ductile deformation is distributed cataclastic pore collapse. We show that a theoretically grounded permeability model for welded granular media accurately captures the permeability of the studied suevites, and we use micromechanical models to glean insight as to their mechanical behaviour. Finally, we upscale our laboratory measurements to provide physical property values for length scales more relevant for large-scale models, and we compare these data with those for basalt (a lithology representative of the surface of the inner Solar System bodies). These analyses show how macroscopic fractures serve to increase the permeability and decrease the strength and Young's modulus of suevite and basalt. We also find, for example, that basalt can be a factor of 2–5 stronger than suevite in the shallow crust. Our study suggests, therefore, that the rock masses comprising older, bombarded crusts are substantially weaker and more porous and permeable than the younger plains material on these bodies. These findings should be considered in large-scale fluid flow modelling and when providing crustal strength estimates or slope stability assessments for planetary bodies on which protracted records of impact bombardment are preserved.

The key goals of the astrobiology community are to identify environments beyond Earth that may be habitable, and to search for signs of life in those environments. A fundamental aspect of understanding the limits of habitable environments and detectable signatures is the study of where such environments can occur. Thus, the need to study the creation, evolution, and frequency of environments hostile to habitability is an integral part of the astrobiology story. The study of these environments provides the opportunity to understand the bifurcation between habitable and uninhabitable conditions on planetary bodies. The archetype of such a planet is Earth's sibling planet, Venus, which provides a unique opportunity to explore the processes that created a completely uninhabitable environment and thus define the conditions that rule out bio-related signatures. We advocate a continued comprehensive study of our neighboring planet, to include models of early atmospheres, compositional abundances, and Venus-analog frequency analysis from current and future exoplanet data. Critically, new missions to Venus that provide in-situ data are necessary to address the major gaps in our current understanding, and to enable us to take the next steps in characterizing planetary habitability., White paper submitted in response to the solicitation of feedback for the "2020 Planetary Science and Astrobiology Decadal Survey" by the National Academy of Sciences

The field of exoplanetary science has emerged over the past two decades, rising up alongside traditional solar system planetary science. Both fields focus on understanding the processes which form and sculpt planets through time, yet there has been less scientific exchange between the two communities than is ideal. This white paper explores some of the institutional and cultural barriers which impede cross-discipline collaborations and suggests solutions that would foster greater collaboration. Some solutions require structural or policy changes within NASA itself, while others are directed towards other institutions, including academic publishers, that can also facilitate greater interdisciplinarity., 8 pages; white paper submitted to the Planetary Science and Astrobiology Decadal Survey 2023-2032

Some human mission trajectories to Mars include flybys of Venus. These flybys provide opportunities to practice deep space human operations, and offer numerous safe-return-to-Earth options, before committing to longer and lower-cadence Mars-only flights. Venus flybys, as part of dedicated missions to Mars, also enable human-in-the-loop scientific study of the second planet. The time to begin coordinating such Earth-to-Mars-via-Venus missions is now, A White Paper for the Planetary Science and Astrobiology Decadal Survey 2023-2032. 7 pages +cover page, 2 figures +cover image

Observations of impact crater morphology can be used to gain insight into the geological history and evolution of a planet's surface. Image data from the Mariner 10 mission revealed the diversity of impact crater morphologies and degradational states on Mercury, leading to early studies that sought to establish a stratigraphic column for the planet, despite only acquiring image data for ~45% of the surface. In 2011, the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft entered orbit around Mercury, returning a high-resolution global image dataset that enables a robust analysis of crater morphology and degradation to be completed for the entirety of Mercury's surface. In this study, we conducted a visual classification of crater degradation according to initial crater morphology, and assigned a degradation state to all craters on Mercury ≥40 km in diameter. In our scheme, Class 1 craters are those that are heavily degraded, and Class 5 craters are very fresh with bright ray systems. We discuss the processes involved in crater degradation and erasure, and the challenges associated with applying crater degradation to derive the timing of geological events. We found that, based on the global spatial density of craters in each class, there appears to be a dearth of Class 1 craters within the intercrater plains, likely due to several ancient basin-sized impacts effectively obliterating a considerable portion of craters ≥40 km in diameter in this region. The crater degradation database we present here will serve as a useful tool for future analyses of Mercury's geological evolution.

The political drive for inclusion means there are increasing numbers of children with autism spectrum disorder (ASD) being educated alongside their neurotypical peers. Pervasive victimisation has prompted the development of peer interventions targeting stigma. This study evaluated the ‘Understanding Our Peers with Pablo’ programme for effects on knowledge, attitudes and behavioural intentions of infant schoolchildren (N = 222) towards autistic peers. Classes were randomly assigned to an intervention or waitlist control condition. Change over time in knowledge of autism and attitudes and behavioural intentions towards familiar and unfamiliar peers was analysed using mixed analyses of variance. The intervention condition showed gains in knowledge and increased positive attitudes towards unfamiliar autistic peers (maintained over three-months). There were significant improvements in attitudes towards familiar autistic peers, and time-limited decreases in behavioural intentions across both conditions. Overall, results support the use of this programme in early-years education.

Professionals who are exposed to trauma through work may indirectly experience distress and traumatisation of their own, often referred to as vicarious traumatisation (VT). Little research has been directed toward the experience of VT among lawyers, especially in terms of how it compares with the VT experienced by mental health professionals (MHPs). This study compares the extent to which exposure to traumatic information affects professionals of different disciplinary backgrounds. Additionally, personality traits that might theoretically influence an individual's vulnerability or resilience to VT are evaluated. Self-report measures were used to investigate symptoms of VT and personality traits in 36 lawyers and 30 MHPs. The results indicate that lawyers and individuals low on the Emotional Stability domain are significantly more susceptible to experiencing symptoms of VT. Exposure to trauma may be better managed by professionals in the mental health field, who have the advantage of having received trauma-specific training and access to informed peer support.

The cerebellum sends dense projections to both motor and non-motor regions of the cerebral cortex via the cerebellarthalamocortical tract. The integrity of this tract is crucial for healthy motor and cognitive function. This systematic review examines research using transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) to the cerebellum with combined cortical electroencephalography (EEG) to explore the temporal features of cerebellar-cortical connectivity. A detailed discussion of the outcomes and limitations of the studies meeting review criteria is presented. Databases were searched between 1 December 2017 and 6 December 2017, with Scopus alerts current as of 23 July 2019. Of the 407 studies initially identified, 10 met review criteria. Findings suggested that cerebellar-cortical assessment is suited to combined TMS and EEG, although work is required to ensure experimental procedures are optimal for eliciting a reliable cerebellar response from stimulation. A distinct variation in methodologies and outcome measures employed across studies, and small sample sizes limited the conclusions that could be drawn regarding the electrophysiological signatures of cerebellar-cortical communication. This review highlights the need for stringent protocols and methodologies for cerebellar-cortical assessments via combined TMS and EEG. With these in place, combined TMS and EEG will provide a valuable means for exploring cerebellar connectivity with a wide range of cortical sites. Assessments have the potential to aid in the understanding of motor and cognitive function in both healthy and clinical groups, and provide insights into long-range neural communication generally.

This study aimed to assess the feasibility of conducting a nutrition trial in adult male prisoners. Adult male prisoners were recruited for a 16-week randomised control trial comparing the effect of ingestion of omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) and multivitamin supplements versus placebo on aggressive behaviour. The baseline and post-intervention assessments from the participant blood samples were the erythrocyte n-3 LCPUFA levels as well as measures of aggressive behaviour determined through institutional records of misconduct (IRM), the Inmate Behaviour Observation Scale (IBOS), and questionnaires. A total of 136 adult male prisoners consented to the study with a retention rate of 60%, and 93% of blood samples were successfully collected. The IRM and IBOS scores were collected for 100% of participants, whilst 82&ndash, 97% of participants completed the questionnaires. From the baseline data, the Odds Ratio shows that prisoners are 4.3 times more likely to have an IBOS &gt, 2 if they are below the 6% cut off on the omega-3 index. Both groups improved across all outcome measures and, at the current sample size, no significant differences were seen between them. A power calculation suggests a total sample size of 600 participants is required to detect the effects of this dietary supplementation, and that this supplementation study is feasible in a Correctional Centre. Important criteria for the exclusion and consideration of logistics and compliance are presented.

This is a white paper submitted to the Planetary Science and Astrobiology Decadal Survey. The Exoplanets in our Backyard meeting was born out of a recognition of the value and potential of interdisciplinary, cross-divisional exoplanet and solar system research, and to encourage and grow the community of researchers working at this intersection. This first-ever inter-assessment group (AG) meeting (organized by members of the Venus Exploration, Outer Planets, and Exoplanet AGs, or VEXAG, OPAG, and ExoPAG, respectively), successfully brought together solar system and exoplanetary scientists from different backgrounds and NASA divisions, fostered communication between researchers whose paths had never crossed at a meeting before, and spurred new collaborations. The meeting was held at the Lunar and Planetary Institute in Houston, TX on February 5-8, 2020 immediately following the OPAG meeting hosted at the same location. The meeting was attended by approximately 110 scientists on site, and 20-30 online participants. The success of this meeting should be capitalized upon and its momentum carried forward to promote fruitful scientific and programmatic discussion, partnerships, and research going forward. This white paper summarizes the meeting, and discusses the findings and action items that resulted., Comment: A White Paper for the Planetary Science and Astrobiology Decadal Survey 2023-2032

Mercury's surface preserves a rich history of volcanism, impact cratering, and tectonic deformation. Geological observations show that the earliest evidence of thrust faulting that was induced by the secular cooling and resulting global contraction of the planet coincided with the waning stages of effusive volcanism, but that explosive volcanism continued beyond this point. Stresses from global contraction, however, would have precluded efficient vertical magma ascent. Sites of pyroclastic activity—manifest as irregular depressions surrounded by diffuse, spectrally distinct halos—spatially coincide with lithospheric discontinuities, such as faults or those associated with impact craters. The vast majority of explosive vents are situated on the floors, rims, central peaks, or peak rings of impact structures. A substantial portion of such vents is also proximal to thrust faults: they are most spatially concentrated at or within 20 km of faults, with ever fewer vents progressively farther from tectonic structures. We statistically evaluated the spatial distribution of sites of pyroclastic activity with respect to faults and impact craters by generating sets of random point locations of equal count to those volcanic sites, computing their spatial relationship to the mapped faults and craters, and comparing them to our observations. We find that although the observed proximity of vents to faults is indistinguishable from a random distribution, their spatial association with impact craters is non-random. To examine the interrelatedness of several geospatial relationships of lithospheric weaknesses and pyroclastic activity, we performed a principal component analysis that tested correlations between vent size, the presence of vents within a crater, the diameters and degradation states of those craters, and vent distance from mapped faults, which help tie together interpretations of magma volumes and eruption energies, repeated utilization of magma pathways, and durations of eruptive events in the geological context of global contraction. Results reveal a predominance of small-sized vents indicative of short-lived, low-volume pyroclastic activity that are consistent with suppressed volcanism after the onset of global contraction. Greater size ranges of vents are found in large impact craters and when faults are nearby, which points to denser fracture networks facilitating magma ascent.

Identifying hospitalized patients with acute severe ulcerative colitis (ASUC) who will be refractory to corticosteroid therapy and require rescue therapy remains difficult. Hypoalbuminemia worsens with time during hospitalization and is associated with rapid clearance of and reduced response to infliximab (IFX) rescue. Early use of rescue therapy may therefore be more effective. Simple clinical and laboratory predictors of corticosteroid responsiveness would facilitate earlier use of rescue therapy.Retrospective study of a prospectively maintained database of 3600 patients attending a single center was conducted. Patients with histologically confirmed ulcerative colitis admitted with ASUC over a 5-year period from January 2010 to December 2014 were identified. All patients initially received intravenous corticosteroids. Patient demographics were collected; C-reactive protein (CRP) and albumin levels were recorded at baseline and during admission. Receiver operating characteristic statistics were used to determine the optimal stool frequency, CRP, albumin, and CRP/albumin ratio (CAR) to predict steroid response.A total of 124 ASUC patients were admitted during a 5-year period. Median follow-up was 2.3 years. A total of 62 patients (50%) were steroid responsive, 55 patients (44%) received rescue IFX, 22 patients (18%) required colectomy within 30 days of admission, whereas a further 14 (11%) required colectomy during follow-up. By receiver operating characteristic statistics, day 3 CAR was a more accurate marker of steroid responsiveness than day 3 CRP or day 3 albumin alone [area under curve=0.75 (P0.001)]. The optimal CAR to predict response to steroids on day 3 was 0.85 (sensitivity 70%, specificity 76%). When combined with D3 stool frequency, specificity improved to 83%. If at day 3, CAR was0.85 and stool frequency was3, the relative risk of steroid nonresponse was significantly raised at 3.9 (95% confidence interval, 2.1-7.2).Raised D3 CAR is an early predictor of steroid-refractory ASUC. When combined with D3 stool frequency, its predictive ability improves. In patients with predicted steroid nonresponse, early introduction of rescue IFX at this stage may be more effective, before serum albumin falls profoundly.

The inhibitory tone that the cerebellum exerts on the primary motor cortex (M1) is known as cerebellar brain inhibition (CBI). Studies show CBI to be relevant to several motor functions, including adaptive motor learning and muscle control. CBI can be assessed noninvasively via transcranial magnetic stimulation (TMS) using a double-coil protocol. Variability in parameter choice and controversy surrounding the protocol's ability to isolate the cerebellothalamocortical pathway casts doubt over its validity in neuroscience research. This justifies a systematic review of both the protocol, and its application. The following review examines studies using the double-coil protocol to assess CBI in healthy adults. Parameters and CBI in relation to task-based studies, other non-invasive protocols, over different muscles, and in clinical samples are reviewed. Of the 1398 studies identified, 24 met selection criteria. It was found that methodological design and selection of parameters in several studies may have reduced the validity of outcomes. Further systematic testing of CBI protocols is warranted, both from a parameter and task-based perspective.

Objectives Many women report declines in cognitive function during pregnancy, but attempts to empirically evaluate such changes have yielded inconsistent results. We aimed to determine whether pregnancy is associated with objective declines in cognitive functioning, and to assess the progression of any declines during pregnancy. Study design We undertook a meta-analysis, applying a random effects model, of 20 studies that have reported quantitative relationships between pregnancy and changes in cognition. Data sources Full text articles indexed by Cumulative Index to Nursing and Allied Health Literature (CINAHL) Complete, MEDLINE Complete, and PsychINFO. Data synthesis The 20 studies assessed included 709 pregnant women and 521 non-pregnant women. Overall cognitive functioning was poorer in pregnant women than in non-pregnant women (standardised mean difference [SMD], 0.52 [95% CI, 0.07-0.97]; P = 0.025). Analysis of cross-sectional studies found that general cognitive functioning (SMD, 1.28 [95% CI 0.26-2.30]; P = 0.014), memory (SMD, 1.47 [95% CI, 0.27-2.68]; P = 0.017), and executive functioning (SMD, 0.46 [95% CI, 0.03-0.89]; P = 0.036) were significantly reduced during the third trimester of pregnancy (compared with control women), but not during the first two trimesters. Longitudinal studies found declines between the first and second trimesters in general cognitive functioning (SMD, 0.29 [95% CI, 0.08-0.50]; P = 0.006) and memory (SMD, 0.33 [95% CI, 0.12-0.54]; P = 0.002), but not between the second and third trimesters. Conclusions General cognitive functioning, memory, and executive functioning were significantly poorer in pregnant than in control women, particularly during the third trimester. The differences primarily develop during the first trimester, and are consistent with recent findings of long term reductions in brain grey matter volume during pregnancy. The impact of these effects on the quality of life and everyday functioning of pregnant women requires further investigation.

Educating the public about antimicrobial resistance (AMR) is considered a key part of an optimal public health response. In both media depictions and policy discourses around health risks, how a problem is framed underpins public awareness and understanding, while also guiding opinions on what actions can and should be taken. Using a mixed methods approach we analyse newspaper content in Australia and the United Kingdom (UK) from 2011 to 2020 to track how causes, consequences and solutions to AMR are represented in countries with different policy approaches. Analyses demonstrate greater variability in the frames used in UK newspapers reflecting large hospital and community outbreaks and a sustained period of policy reform mid-decade. Newspapers in Australia focus more on AMR causes and consequences, highlighting the importance of scientific discovery, whereas UK coverage has greater discussion of the social and economic drivers of AMR and their associated solutions. Variations in the trends of different frames around AMR in UK newspapers indicate greater levels of public deliberation and debate around immediate and actionable solutions; whereas AMR has not had the same health and political impacts in Australia resulting in a media framing that potentially encourages greater public complacency about the issue.

Both endogenic and exogenic formation mechanisms have been proposed for the equatorial ridge on Saturn's moon Iapetus. With photogeological mapping and crater statistics, we find that the morphology of the ridge is best explained by an exogenic origin, principally by the accretion onto the moon's surface of an orbiting ring of material.

Surface roughness is a statistical measure of change in surface height over a given spatial horizontal scale after the effect of broad scale slope has been removed, and can be used to understand how geologic processes produce and modify a planet's topographic character at different scales. The statistical measure of surface roughness employed in this study of Mercury was the root-mean-square (RMS) deviation, and was calculated from 45–90°N at horizontal baselines of 0.5-250 km with detrended topographic data from individual Mercury Laser Altimeter tracks. As seen in previous studies, the surface roughness of Mercury has a bimodal spatial distribution, with the cratered terrain (dominated by the intercrater plains) possessing higher surface roughness than the smooth plains. The measured surface roughness for both geologic units is controlled by a trade off between impact craters generating higher surface roughness values and flood-mode volcanism decreasing surface roughness. The topography of the two terrain types has self-affine-like behavior at baselines from 0.5–1.5 km; the smooth plains collectively have a Hurst exponent of 0.88 +/- 0.01, whereas the cratered terrains have a Hurst exponent of 0.95 +/- 0.01. Subtle variations in the surface roughness of the smooth plains can be attributed to differences in regional differences in the spatial density of tectonic landforms. The northern rise, a 1,000-km-wide region of elevated topography centered at 65° N, 40° E, is not distinguishable in surface roughness measurements over baselines of 0.5–250 km.

The first author acknowledges funding from an Initiative d’Excellence (IDEX) “Attractivité” grant (VOLPERM), funded by the University of Strasbourg. M.H. also acknowledges support from the CNRS (INSU 2016-TelluS-ALEAS). Surface gravitational acceleration (surface gravity) on Mars, the second-smallest planet in the Solar System, is much lower than that on Earth. A direct consequence of this low surface gravity is that lithostatic pressure is lower on Mars than on Earth at any given depth. Collated published data from deformation experiments on basalts suggest that, throughout its geological history (and thus thermal evolution), the Martian brittle lithosphere was much thicker but weaker than that of present-day Earth as a function solely of surface gravity. We also demonstrate, again as a consequence of its lower surface gravity, that the Martian lithosphere is more porous, that fractures on Mars remain open to greater depths and are wider at a given depth, and that the maximum penetration depth for opening-mode fractures (i.e., joints) is much deeper on Mars than on Earth. The result of a weak Martian lithosphere is that dykes—the primary mechanism for magma transport on both planets—can propagate more easily and can be much wider on Mars than on Earth. We suggest that this increased the efficiency of magma delivery to and towards the Martian surface during its volcanically active past, and therefore assisted the exogeneous and endogenous growth of the planet's enormous volcanoes (the heights of which are supported by the thick Martian lithosphere) as well as extensive flood-mode volcanism. The porous and pervasively fractured (and permeable) nature of the Martian lithosphere will have also greatly assisted the subsurface storage of and transport of fluids through the lithosphere throughout its geologically history. And so it is that surface gravity, influenced by the mass of a planetary body, can greatly modify the mechanical and hydraulic behaviour of its lithosphere with manifest differences in surface topography and geomorphology, volcanic character, and hydrology. Postprint

BACKGROUND: An association between increasing anaesthetic depth and decreased postoperative survival has been shown in observational studies; however, evidence from randomised controlled trials is lacking. Our aim was to compare all-cause 1-year mortality in older patients having major surgery and randomly assigned to light or deep general anaesthesia.METHODS: In an international trial, we recruited patients from 73 centres in seven countries who were aged 60 years and older, with significant comorbidity, having surgery with expected duration of more than 2 h, and an anticipated hospital stay of at least 2 days. We randomly assigned patients who had increased risk of complications after major surgery to receive light general anaesthesia (bispectral index [BIS] target 50) or deep general anaesthesia (BIS target 35). Anaesthetists also nominated an appropriate range for mean arterial pressure for each patient during surgery. Patients were randomly assigned in permuted blocks by region immediately before surgery, with the patient and assessors masked to group allocation. The primary outcome was 1-year all-cause mortality. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12612000632897, and is closed to accrual.FINDINGS: Patients were enrolled between Dec 19, 2012, and Dec 12, 2017. Of the 18 026 patients screened as eligible, 6644 were enrolled, randomly assigned to treatment or control, and formed the intention-to-treat population (3316 in the BIS 50 group and 3328 in the BIS 35 group). The median BIS was 47·2 (IQR 43·7 to 50·5) in the BIS 50 group and 38·8 (36·3 to 42·4) in the BIS 35 group. Mean arterial pressure was 3·5 mm Hg (4%) higher (median 84·5 [IQR 78·0 to 91·3] and 81·0 [75·4 to 87·6], respectively) and volatile anaesthetic use was 0·26 minimum alveolar concentration (30%) lower (0·62 [0·52 to 0·73] and 0·88 [0·74 to 1·04], respectively) in the BIS 50 than the BIS 35 group. 1-year mortality was 6·5% (212 patients) in the BIS 50 group and 7·2% (238 patients) in the BIS 35 group (hazard ratio 0·88, 95% CI 0·73 to 1·07, absolute risk reduction 0·8%, 95% CI -0·5 to 2·0). Grade 3 adverse events occurred in 954 (29%) patients in the BIS 50 group and 909 (27%) patients in the BIS 35 group; and grade 4 adverse events in 265 (8%) and 259 (8%) patients, respectively. The most commonly reported adverse events were infections, vascular disorders, cardiac disorders, and neoplasms.INTERPRETATION: Among patients at increased risk of complications after major surgery, light general anaesthesia was not associated with lower 1-year mortality than deep general anaesthesia. Our trial defines a broad range of anaesthetic depth over which anaesthesia may be safely delivered when titrating volatile anaesthetic concentrations using a processed electroencephalographic monitor.FUNDING: Health Research Council of New Zealand; National Health and Medical Research Council, Australia; Research Grant Council of Hong Kong; National Institute for Health and Research, UK; and National Institutes of Health, USA.

Data from Mariner 10, MESSENGER, and ground-based telescopic observations have facilitated great advancements towards understanding the geochemistry, geology, internal structure, exosphere, and magnetosphere of Mercury. However, there are critical science questions that can be only addressed via examination of a sample in Earth-based laboratories, where numerous highly sensitive analytical measurements are possible. Collecting a sample from the surface of Mercury and bringing it to Earth for in-depth analysis would allow for transformative Solar System science to be conducted, examining aspects of our Solar System such as the evolution of the protoplanetary disk, space weathering on airless bodies, the geochemical behavior of elements at extreme conditions, and the origin and distribution of volatiles across the terrestrial planets. Furthermore, our knowledge of Mercury’s differentiation and geochemical processes, chronology and geologic evolution, tectonism and geomechanical properties, and past and ongoing magnetism would be greatly advanced via analysis of a sample from Mercury. Although there are ample challenges and knowledge gaps associated with sample return from Mercury in terms of both spacecraft requirements and material requirements for curatorial facilities, a sample from the planet would be an invaluable scientific resource for generations to come, enabling the most sophisticated measurements to be brought to bear for decades and helping to truly unlock the mysteries of our Solar System.

Poor working memory functioning is commonly found in schizophrenia. A number of studies have now tested whether non-invasive brain stimulation can improve this aspect of cognitive functioning. This report used meta-analysis to synthesise the results of these studies to examine whether transcranial electrical stimulation (tES) or repetitive transcranial magnetic stimulation (rTMS) can improve working memory in schizophrenia. The studies included in this meta-analysis were sham-controlled, randomised controlled trials that utilised either tES or rTMS to treat working memory problems in schizophrenia. A total of 22 studies were included in the review. Nine studies administered rTMS and 13 administered tES. Meta-analysis revealed that compared to sham/placebo stimulation, neither TMS nor tES significantly improved working memory. This was found when working memory was measured with respect to the accuracy on working memory tasks (TMS studies: Hedges' g = 0.112, CI

Background Antimicrobial resistance is a global public health concern, with extensive associated health and economic implications. Actions to slow and contain the development of resistance are imperative. Despite the fact that overuse and misuse of antibiotics are highlighted as major contributing factors to this resistance, no sufficiently validated measures aiming to investigate the drivers behind consumer behaviour amongst the general population are available. The objective of this study was to develop and investigate the psychometric properties of an original, novel and multiple-item questionnaire, informed by the Theory of Planned Behaviour, to measure factors contributing to self-reported antibiotic use within the community. Method A three-phase process was employed, including literature review and item generation; expert panel review; and pre-test. Investigation of the questionnaire was subsequently conducted through a cross-sectional, anonymous survey. Orthogonal principal analysis with varimax rotation, cronbach alpha and linear mixed-effects modelling analyses were conducted. A 60 item questionnaire was produced encompassing demographics, social desirability, three constructs of the Theory of Planned Behaviour including: attitudes and beliefs; subjective norm; perceived behavioural control; behaviour; and a covariate – knowledge. Results Three hundred seventy-three participants completed the survey. Eighty participants (21%) were excluded due to social desirability concerns, with data from the remaining 293 participants analysed. Results showed modest but acceptable levels of internal reliability, with high inter-item correlations within each construct. All four variables and the outcome variable of antibiotic use behaviour comprised four items with the exception of social norms, for which there were two items, producing a final 18 item questionnaire. Perceived behavioural control, social norms, the interaction between attitudes and beliefs and knowledge, and the presence of a healthcare worker in the family were all significant predictors of antibiotic use behaviour. All other predictors tested produced a nonsignificant relationship with the outcome variable of self-reported antibiotic use. Conclusion This study successfully developed and validated a novel tool which assesses factors influencing community antibiotic use and misuse. The questionnaire can be used to guide appropriate intervention strategies to reduce antibiotic misuse in the general population. Future research is required to assess the extent to which this tool can guide community-based intervention strategies.