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560 results on '"Johns, Edward J."'

118. Characterization of renal hemodynamic and structural alterations in rat models of renal impairment: role of renal sympathoexcitation

Author

Salman, Ibrahim M., primary, Ameer, Omar Z., additional, Sattar, Munavvar A., additional, Abdullah, Nor A., additional, Yam, Mun F., additional, Najim, Hafsa S., additional, Abdulkarim, Muthanna F., additional, Abdullah, Ghassan Z., additional, Kaur, Gurjeet, additional, Khan, Md. Abdul Hye, additional, and Johns, Edward J., additional

Published
2010
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138. A critical review of pharmacological significance of Hydrogen Sulfide in hypertension.

Author

Ahmad, Ashfaq, Sattar, Munavvar A., Rathore, Hassaan A., Khan, Safia Akhtar, Lazhari, M. I., Afzal, Sheryar, Hashmi, F., Abdullah, Nor A., and Johns, Edward J.

Subjects
HYDROGEN sulfide, THERAPEUTICS, CARDIOVASCULAR disease prevention, HYPERTENSION, CYSTATHIONINE gamma-lyase, CYSTATHIONINE beta-synthase
Abstract

In the family of gas transmitters, hydrogen sulfide (H2S) is yet not adequately researched. Known for its rotten egg smell and adverse effects on the brain, lungs, and kidneys for more than 300 years, the vasorelaxant effects of H2S on blood vessel was first observed in 1997. Since then, research continued to explore the possible therapeutic effects of H2S in hypertension, inflammation, pancreatitis, different types of shock, diabetes, and heart failure. However, a considerable amount of efforts are yet needed to elucidate the mechanisms involved in the therapeutic effects of H2S, such as nitric oxide-dependent or independent vasodilation in hypertension and regression of left ventricular hypertrophy. More than a decade of good repute among researchers, H2S research has certain results that need to be clarified or reevaluated. H2S produces its response by multiple modes of action, such as opening the ATP-sensitive potassium channel, angiotensin-converting enzyme inhibition, and calcium channel blockade. H2S is endogenously produced from two sulfur-containing amino acids L-cysteine and L-methionine by the two enzymes cystathionine γ lyase and cystathionine β synthase. Recently, the third enzyme, 3-mercaptopyruvate sulfur transferase, along with cysteine aminotransferase, which is similar to aspartate aminotransferase, has been found to produce H2S in the brain. The H2S has interested researchers, and a great deal of information is being generated every year. This review aims to provide an update on the developments in the research of H2S in hypertension amid the ambiguity in defining the exact role of H2S in hypertension because of insufficient number of research results on this area. This critical review on the role of H2S in hypertension will clarify the gray areas and highlight its future prospects. [ABSTRACT FROM AUTHOR]

Published
2015
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139. Functional contribution of α1D-adrenoceptors in the renal vasculature of left ventricular hypertrophy induced with isoprenaline and caffeine in Wistar-Kyoto rats.

Author

Ahmad, Ashfaq, Sattar, Munavvar A., Rathore, Hassaan A., Abdulla, Mohammad H., Khan, Safia A., Abdullah, Nor A., Kaur, Gurjeet, and Johns, Edward J.

Subjects
ADRENERGIC receptors, LEFT ventricular hypertrophy, VASOCONSTRICTORS, PHENYLEPHRINE, NORADRENALINE
Abstract

Copyright of Canadian Journal of Physiology & Pharmacology is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2014
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