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A study conducted at Ganzhou People's Hospital in Jiangxi, China, aimed to improve the understanding and management of lymphoma-associated hemophagocytic syndrome (LAHS), a rare and fatal disease. The study included 26 patients diagnosed with non-Hodgkin lymphoma-associated hemophagocytic syndrome between 2008 and 2022. The findings showed that patients with T/NK cell lymphoma, compared to those with B cell lymphoma, were younger, had lower platelet count and fibrinogen concentration, higher blood beta 2-microglobulin levels and ferritin, and were more likely to be infected with Epstein-Barr virus. The study concluded that early anti-inflammatory treatment combined with antilymphoma therapy can improve overall survival time, and further research with larger sample sizes and longer follow-up periods is needed to investigate optimal treatment and prognosis. [Extracted from the article]

A study conducted by researchers at Jiujiang University in Jiangxi, China, explored the expression of exosomal lncRNA-HEIH in patients with hepatitis B virus-associated hepatocellular carcinoma (B-HCC). The study found a positive correlation between hepatitis B virus and exosomal lncRNA-HEIH in the B-HCC group. Additionally, the high expression of exosomal lncRNA-HEIH was associated with a significantly lower 5-year survival rate in the B-HCC group. The researchers concluded that exosomal lncRNA-HEIH could serve as a potential diagnostic and therapeutic target for HBV-associated HCC. [Extracted from the article]

A recent study conducted by researchers at Nanchang University in Jiangxi, China, explored the potential of overexpressing the DNA repair/recombination protein 54 L (RAD54L) to attenuate osteoarthritis (OA). The researchers conducted bioinformatics analysis and experimental validation to investigate the effects of RAD54L overexpression on OA. The results showed that RAD54L overexpression promoted cell viability, reduced apoptosis, and decreased the expression of inflammatory mediators in chondrocytes. Additionally, in vivo experiments on OA rats demonstrated a lower OA severity score and reduced inflammatory response in cartilage tissues after RAD54L overexpression. The study suggests that RAD54L may be a potential treatment target for OA by suppressing the HIF-1 alpha/VEGF signaling pathway. [Extracted from the article]

A recent study conducted at South University in Jiangxi, China, explores the potential pathogenesis of Amyotrophic Lateral Sclerosis (ALS), a fatal neurodegenerative disease. The study highlights various factors that may contribute to the development of ALS, including genetic variation, gut microbial dysbiosis, glial cell activation, and transportation disorder of extracellular vesicles. The researchers emphasize the importance of understanding the pathogenesis of ALS in order to develop effective treatment measures. This systematic review aims to provide new evidence and clues for novel treatment approaches for ALS. The study was supported by the National Natural Science Foundation of China. [Extracted from the article]

A study conducted by researchers at Gannan Medical University in Jiangxi, China, explores the role of a natural flavonoid called 5,7,3',4'-tetramethoxyflavone (TMF) in suppressing chondrocyte hypertrophy, a key factor in the development of osteoarthritis (OA). The study found that TMF inhibited the expression of collagen X and Runx2, inhibited the BMPER/BMP4/Smad1 signaling pathway, and activated the expression of Forkhead box protein O3a (FOXO3a), thereby protecting against chondrocyte hypertrophy and OA development. However, the protective effects of TMF were impacted by BMPER overexpression and FOXO3a knockdown. The study concludes that TMF suppresses chondrocyte hypertrophy in OA cartilage by mediating the FOXO3a/BMPER signaling pathway. [Extracted from the article]

A study conducted at Nanchang University in Jiangxi, China, explored the role of a long non-coding RNA (lncRNA) called BRE-AS1 in clear cell renal cell carcinoma (ccRCC). The study found that the expression of BRE-AS1 was decreased in ccRCC tissues, while the expression of miR-106b-5p was increased. BRE-AS1 was found to be associated with the prognosis of ccRCC patients and was inversely correlated with miR-106b-5p expression. Overexpression of BRE-AS1 inhibited the movement and proliferation of ccRCC cell lines, while miR-106b-5p suppressed the role of BRE-AS1. The study suggests that BRE-AS1 may suppress ccRCC by downregulating miR-106b-5p expression. [Extracted from the article]

Researchers from Nanchang University in Jiangxi, China have conducted a study on the incidence of different pressure patterns of spinal cerebellar ataxia (SCA) and the analysis of imaging and genetic diagnosis. The study found that autosomal-dominant mutations in SCA genes, particularly SCA6, are common in individuals with sporadic cerebellar ataxia. The research suggests that the increased incidence of SCA6 mutations may be related to a greater age of onset and varied penetrance of the mutations. This study provides valuable insights for neurologists in identifying and diagnosing sporadic cerebellar ataxia. [Extracted from the article]

Researchers from Jiangxi Science and Technology Normal University in China have developed a reusable, healable, and biocompatible electrical bioadhesive interface (EBI) for high-resolution electromyography (EMG) monitoring. The EBI incorporates a dynamic non-covalent interaction enhancer called polydopamine (PDA) and conductive PEDOT:PSS into an adhesive hydrogel matrix. The EBI exhibits high conductivity, tissue-like mechanical properties, low interfacial impedance, and excellent adhesion strength. The researchers demonstrated the fabrication and application of a reusable EMG monitoring patch using the EBI, which showed higher signal-to-noise ratio and stability compared to commercial electrodes. This research has been peer-reviewed and offers a promising solution for enhancing the accuracy and convenience of EMG monitoring. [Extracted from the article]

A systematic review and meta-analysis conducted by researchers from Gannan Medical University in China evaluated the efficacy and safety of different inhaled corticosteroids (budesonide, beclomethasone, and fluticasone propionate) in preventing bronchopulmonary dysplasia (BPD) in premature infants. The study found that budesonide, particularly when administered through intratracheal instillation with surfactant as a vehicle, was associated with a lower risk of BPD and patent ductus arteriosus compared to control treatments. However, beclomethasone and fluticasone propionate did not show any superior or inferior effects on clinical outcomes. The researchers concluded that more large-scale trials with long-term follow-ups are needed to confirm these findings. [Extracted from the article]

A report from researchers at Nanchang University in China has examined the implementation of precautionary allergen labeling (PAL) in the country. The study found that a significant number of pre-packaged snack foods contained levels of egg and milk proteins that exceeded the recommended threshold. The researchers concluded that the current PAL approach in China leads to excessive labeling, which diminishes the value of the information for consumers. They recommend strengthening the risk assessment and management of cross-contact allergens in the food industry and establishing a PAL system to effectively communicate risks to consumers. [Extracted from the article]

A report from Nanchang University in Jiangxi, China, discusses the impact of sub-inhibitory concentrations of tetrabromobisphenol A (TBBPA) on the biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA). The study found that TBBPA significantly stimulated MRSA biofilm formation and increased the production of key biofilm components. TBBPA also enhanced MRSA survival under adverse conditions and upregulated genes associated with biofilm formation and oxidative stress responses. These findings suggest that TBBPA may promote MRSA biofilm development and enhance bacterial resistance, potentially posing risks to human health. The research has been peer-reviewed. [Extracted from the article]

A recent study conducted by researchers from Nanchang University in China explored the relationship between systemic immune-inflammatory index (SII) and female sexual dysfunction (FSD), specifically low sexual frequency, in depressed patients. The study analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2016, involving 1042 depressed female participants. The results showed that a higher SII was associated with a decreased likelihood of FSD, suggesting the potential role of inflammation in female sexual health. The study also found a U-shaped relationship between SII and FSD, with an inflection point of 2100. [Extracted from the article]

A report from Jiangxi Science and Technology Normal University in China presents new findings on genomics and genetics. The researchers modified a compound called Mobocertinib to create new inhibitors for a specific mutation of the EGFR gene. They synthesized 63 derivatives of Mobocertinib and found that one particular compound, H-13, showed promising antitumor activity in vitro and in vivo. The researchers concluded that H-13 has the potential to be a third-generation EGFR inhibitor. This research has been peer-reviewed and published in the journal Bioorganic Chemistry. [Extracted from the article]

A study conducted by researchers at Nanchang University in Jiangxi, China, has developed a new method for encapsulating probiotics using a shell-core microbead. The microbead consists of a lipid core surrounded by a gelatin and/or pectin shell film. The addition of pectin and cross-linking with calcium ions improved the properties of the shell film. The microbeads demonstrated high retention of probiotic activity and resistance to enzymatic hydrolysis during gastrointestinal digestion. The researchers concluded that microbeads are a promising platform for delivering probiotics to the intestines. [Extracted from the article]

A study conducted by investigators from Gannan Medical University in Jiangxi, China, explores the role of pyroptosis, a type of programmed immunogenic cell death, in gliomas. The researchers identified differentially expressed genes (DEGs) and hub genes in gliomas through bioinformatics analysis. They found that silencing the GNB4 gene promoted pyroptosis and inhibited the proliferation, migration, and invasion of glioma cells by activating the cGAS-STING pathway. This research suggests that GNB4 could be a potential biomarker and therapeutic target for glioma treatment. [Extracted from the article]

A study conducted by Nanchang Normal University in Jiangxi, China, explores the impact of expressive ties (EI) on the competitive performance (CP) of DanceSport couples. The study found that the perceived quality of EI positively correlated with CP for both male and female dancers. Additionally, the study revealed that athlete engagement (AE) partially mediated the impact of EI on CP. The findings suggest that the self-determination theory should consider individual gender characteristics. [Extracted from the article]

A recent study conducted by Nanchang University in Jiangxi, China, explored the impact of in-person and remote Satir family therapy on the emotions and behavior of adolescents with major depressive disorder. The study found that this therapy effectively reduced anxiety and depression levels, as well as non-suicidal self-injury behavior and problematic mobile phone use. The researchers concluded that this therapy model could be successfully applied to the outpatient management of adolescents with major depressive disorder, particularly in rural areas. This research provides valuable insights into improving the recognition and treatment of depression in adolescents. [Extracted from the article]

A recent study conducted in Jiangxi, People's Republic of China, explored the relationship between children's food allergy symptoms and maternal depression. The study included 580 children with food allergies and their mothers, and assessed the severity of children's food allergy symptoms and the depressive symptoms of the mothers. The findings revealed that higher levels of food allergy symptoms in children were associated with a higher prevalence of depression in their mothers. This research provides valuable insights into the impact of food allergies on maternal mental health. [Extracted from the article]

A study conducted in Jiangxi, People's Republic of China, investigated the role of chemotactic cytokine binding protein D6 in the tumorigenicity and metastasis of breast cancer cells. The researchers analyzed different breast cancer cell lines and normal breast epithelial cells to explore the levels of D6 messenger ribonucleic acid (RNA) and its relationship with other factors. The study found that D6 is a negative regulator in breast cancer, inhibiting the tumorigenicity and metastasis of breast cancer cells. This research has been peer-reviewed and published in the Indian Journal of Pharmaceutical Sciences. [Extracted from the article]

A recent report from Jiangxi Province People's Hospital in China discusses the role of Netrin-1 (NTN-1) in inflammatory pain (IP). The researchers found that NTN-1 plays a vital role in the development of the nervous system and inflammatory diseases, but its role in IP was unclear. Through their study, they discovered that overexpressing NTN-1 inhibited pyroptosis (a form of cell death) and promoted the activation of microglial cells, leading to a decrease in inflammatory injury and an increase in anti-inflammatory response. These findings suggest that NTN-1 may have a protective role in alleviating inflammatory pain. [Extracted from the article]

A research study conducted in Jiangxi, People's Republic of China, explored the role and mechanism of integrin alpha 5 in a rat model of breast cancer bone metastasis. The study used a lentiviral vector to silence the expression of integrin alpha 5 in breast cancer cells. The results showed that silencing integrin alpha 5 effectively inhibited the growth, metastasis, and adhesion of breast cancer cells, as well as bone metastasis. The mechanism may involve inhibiting the expression of non-muscle myosin heavy chain II and p-S1943 proteins. This research has been peer-reviewed and provides valuable insights into breast cancer treatment. [Extracted from the article]

A study conducted by researchers at Nanchang University in Jiangxi, China, has found that human milk oligosaccharide 2'-fucosyllactose (2'FL) may have a protective effect against ulcerative colitis (UC). The researchers established colitis in mice and measured various factors related to inflammation, gut microbiota, intestinal barrier function, and molecular signaling pathways. The results showed that 2'FL alleviated colitis symptoms, reduced inflammation, promoted the production of anti-inflammatory cytokines, restored intestinal barrier integrity, and reversed changes in gut microbiota. The study suggests that 2'FL supplementation could be a promising nutritional strategy for alleviating UC and related diseases. [Extracted from the article]

A report from Nanchang University in Jiangxi, China discusses the potential health benefits of hydrolyzed fucoidan, a type of bacterial polysaccharide. The study found that low-molecular weight hydrolyzed fucoidan can positively impact the microbiota and metabolome when fermented in vitro with human fecal cultures. The research suggests that hydrolyzed fucoidan has the potential for targeted regulation of microbial communities and could have therapeutic applications. The study was funded by various scientific foundations in China and has been peer-reviewed. [Extracted from the article]

A recent study conducted by Nanchang University in Jiangxi, China compared the prognosis of bacteremic pneumonia caused by Klebsiella pneumoniae (KP-BP) and Escherichia coli (E. coli-BP) pathogens. The study analyzed clinical data from 162 patients diagnosed with bacterial pneumonia between 2016-2019. The 30-day mortality rate was found to be higher in the KP-BP group (43.75%) compared to the E. coli-BP group (21.95%). However, after adjusting for confounding variables, the study found that patients diagnosed with KP-BP had a similar prognosis to those diagnosed with E. coli-BP. The study also identified factors such as being in the intensive care unit, infection with carbapenem-resistant strains, and a high sequential organ failure assessment score as risk factors for mortality in KP-BP patients. [Extracted from the article]

A recent study conducted in Jiangxi, People's Republic of China, explored the psychological experiences and needs of tumor patients with implanted intravenous infusion ports. The study found that patients experienced a lack of self-worth, multiple emotional experiences (including guilt, doubt, worry, and gain), poor self-management and self-maintenance awareness, and had expectations and suggestions for the future. The researchers concluded that careful monitoring of the patient's psychological state during tube implantation is necessary to relieve tension and anxiety and improve nursing satisfaction and patient outcomes. This study provides valuable insights for psychological interventions in tumor patients with intravenous infusion ports. [Extracted from the article]

A research report from Ganzhou People's Hospital in Jiangxi, China, discusses the role of circular RNAs (circRNAs) in the development of acute pancreatitis (AP). The study found that a specific circRNA, circ_0029407, is overexpressed in AP serum samples and caerulein-stimulated human pancreatic epithelial cells (HPECs). Reduction of circ_0029407 was shown to attenuate caerulein-induced damage to HPECs by promoting cell proliferation and suppressing cell apoptosis and inflammation. The study suggests that circ_0029407 regulates cell injury in human pancreatic cells through the toll-like receptor 4 (TLR4)/nuclear factor NF-kappa B (NF-kappa B) signaling pathway by functioning as a competing endogenous RNA (ceRNA) for miR-579-3p. [Extracted from the article]

A recent report from Nanchang University in Jiangxi, China explores the potential therapeutic benefits of rutin, a plant-based flavonoid, in inhibiting lactate dehydrogenase (LDH), an enzyme involved in tumor cell metabolism. The study found that rutin binds to LDH, forming a stable complex through hydrophobic forces and hydrogen bonds. Rutin also affects the secondary structure of LDH and enhances the stability of coenzyme binding, potentially hindering the conversion process among coenzymes. The research suggests that rutin may have medicinal value and provides valuable insights into its therapeutic potential. [Extracted from the article]

A study conducted at Jiangxi Science and Technology Normal University in China has developed a composite antimicrobial nanomaterial that combines a cell-penetrating peptide with a two-dimensional MOF for biosensor diagnosis and therapy. The nanomaterial demonstrated effective inhibition against E. coli and S. aureus, as well as sustained release of reactive oxygen species and photothermal properties. In the context of wound infections, the nanomaterial showed optimal skin wound healing and reduced inflammation. This research holds potential for clinical treatments and monitoring of bacterial infections. [Extracted from the article]

Researchers at Nanchang University in Jiangxi, China have conducted a study on the function of E26 transcription factor families in gastric cancer (GC) and their association with prognosis. The study found that the dysregulation of 28 genes in the ETS family was associated with multiple clinicopathological features of GC. The researchers constructed a prognostic model based on the ETS family and found that ELK3, one of the genes in the model, was significantly overexpressed in GC clinical samples. In vitro and in vivo studies confirmed that ELK3 regulates GC proliferation and metastasis, suggesting it as a potential therapeutic target for gastric cancer. [Extracted from the article]

A study conducted by researchers at Nanchang University in Jiangxi, China, has found that the purinergic 2X7 receptor (P2X7R) plays a significant role in tumor progression and the development of cancer-related pain. The receptor is activated by extracellular ATP, which affects intracellular molecular metabolism and regulates the activity of tumor cells. Additionally, the expression of P2X7R in nerve cells is upregulated during tumor progression, leading to increased pain sensitivity. The study suggests that inhibiting P2X7R activity or blocking its expression could be a potential therapeutic approach for treating tumors and cancer-related pain. The research was supported by the Science and Technology Plan Project of Jiangxi Health Commission. [Extracted from the article]

Researchers from Jiangxi Cancer Hospital in the People's Republic of China have published a report on the progress of engineered bacteria for tumor therapy. The study highlights the use of bacterial therapeutics in preventing tumor spread and recurrence, either alone or in combination with traditional therapies. The researchers discuss the advancements made in the field, including the development of engineered bacteria, their integration with other therapeutic techniques, and the current state of clinical trials. They also address the limitations and challenges faced in utilizing engineered bacteria for tumor therapy. This research has been peer-reviewed and provides valuable insights into the potential of engineered bacteria in cancer treatment. [Extracted from the article]

A study conducted by researchers at Nanchang University in Jiangxi, China, focuses on the segmentation of brain tumors, which is crucial for accurate diagnosis and treatment. The researchers propose an end-to-end convolutional neural network with a U-shaped structure that incorporates a multi-scale context block and an attention guidance block to enhance network representations and improve the model's learning capability. The recommended approach achieves favorable results in terms of segmentation accuracy compared to other existing methods. The study concludes that this approach has clinical value and accurately segments the three lesion regions of the brain. [Extracted from the article]

A study conducted in Jiangxi, People's Republic of China, explored the use of intratumoral and peritumoral multiparametric magnetic resonance imaging (MRI)-based radiomics signature (RS) for predicting the Ki-67 proliferation status in glioblastoma. The study analyzed data from 205 patients with glioblastoma from two institutions. The results showed that the multiparametric RS combining intratumoral and peritumoral features can be a noninvasive and effective tool for preoperative assessment of Ki-67 proliferation status in glioblastoma. The study was published in Academic Radiology and has been peer-reviewed. [Extracted from the article]

Researchers at Jiangxi University in the People's Republic of China have published a study on the promotion of vascular reendothelialization to inhibit endothelial proliferation, which is essential for preventing in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). The study focused on the mechanism by which Detoxification and Activating Blood Circulation Decoction (DABCD) promotes vascular reendothelialization through miRNA-126-mediated modulation of the vascular endothelial growth factor (VEGF) signaling pathway. The findings showed that DABCD reduced intimal hyperplasia and inflammation, promoted vascular reendothelialization, increased nitric oxide (NO) expression, and decreased ET-1 production. The study concluded that DABCD's effects were mediated through miR-126-mediated VEGF signaling pathway activation. [Extracted from the article]

Researchers at Ganzhou People's Hospital in Jiangxi, People's Republic of China, have conducted a study on intervertebral disc degeneration (IVDD) and its association with chronic inflammation and cell death. They created an IVDD rat model using Interleukin-1 beta (IL-1 beta) injection and assessed the degeneration of intervertebral disc tissues using various techniques. The study identified differentially expressed genes (DEGs) between the IVDD model and control rats and found that silencing the DEAD-box polypeptide 3 (DDX3) gene promoted cell proliferation and inhibited IL-1 beta-induced cell apoptosis and pyroptosis. The findings suggest that DDX3 may be a potential target for IVDD management. [Extracted from the article]

A study conducted by researchers at Nanchang University in Jiangxi, China, has found that methionine restriction (MR) can reduce the invasiveness and motility of gastric carcinoma cells, which are responsible for gastric cancer metastasis. The study investigated the mechanisms of MR on gastric carcinoma metastasis using in vitro and in vivo experiments. The researchers discovered that Kuppel like factor 10 (KLF10) and cystathionine beta-synthase (CBS) play a role in increasing the sensitivity of gastric carcinoma cells to MR by promoting the sulfur transfer pathway. This research provides insights into potential therapeutic strategies for gastric cancer treatment. [Extracted from the article]

A new study conducted by investigators at Nanchang University in Jiangxi, China, explores the use of cell instance segmentation (CIS) through light microscopy and artificial intelligence (AI) in cell and gene therapy-based healthcare management. The researchers propose a deep learning model called CellT-Net, which incorporates the Swin transformer (Swin-T) to effectively segment cells. The model utilizes a novel composite style called cross-level composition (CLC) to generate more representational features. The study concludes that CellT-Net outperforms other models in dealing with the challenges posed by cell datasets. This research has been peer-reviewed and published in the IEEE Journal of Biomedical and Health Informatics. [Extracted from the article]

A recent study conducted by researchers from Nanchang University in Jiangxi, China, explores the impact of the P2X7 receptor (P2X7R) on the tumor immune microenvironment (TME) and its effects on tumor progression. The TME refers to the environment in which tumors exist and has been found to be closely related to tumor growth, invasion, and metastasis. The study provides an overview of the structure, function, and pharmacological characteristics of P2X7R, as well as its role in inflammation, immune responses, angiogenesis, immunogenic cell death, and tumor development. The researchers also discuss the effects of drugs targeting P2X7R on tumor progression, offering potential avenues for future research and treatment. [Extracted from the article]

A report from Nanchang University in Jiangxi, China, explores the role of macrophages in food allergies. The study focuses on the relationship between macrophage polarization and allergic responses induced by tropomyosin (TM). The research found that macrophages were mainly polarized toward M2 phenotypes in vitro and that macrophage polarization plays an important role in food allergy. These findings suggest that macrophages could be a target for future treatments for food allergies. [Extracted from the article]

A study conducted at Nanchang University in Jiangxi, China, explored the diagnostic value of nonintrusive left ventricular pressure-strain loop (LV-PSL) in assessing overall myocardial function in patients with non-ST-segment elevation acute coronary syndrome (NSTEACS) with or without coronary stenosis. The researchers enrolled 268 patients with NSTEACS and performed noninvasive LV-PSL construction before coronary angiography. They found that the LV-PSL method could identify the presence of acute coronary stenosis and detect varying degrees of left ventricular dysfunction in NSTEACS patients. The study concluded that the global work efficiency (GWE) index had the highest diagnostic efficiency for diagnosing NSTEACS patients with coronary stenosis and the highest predictive ability for adverse cardiac events. [Extracted from the article]

A recent study conducted by researchers at Jiangxi Science and Technology Normal University in China explores a new therapeutic approach to combat bacterial infections. The study focuses on the development of a nanozyme called LL-37-HA-AuPt@PCN-224, which has shown promising results in synergistic antibacterial therapy and fluorescence imaging of wound bacterial infections. The nanozyme catalyzes the conversion of H2O2 into O2 and center dot OH, and further catalyzes O2 into 1O2. In vitro and in vivo experiments demonstrate the nanozyme's effectiveness in enhancing the healing efficiency of bacteria-infected wounds. The study concludes that nanozymes have potential as antibacterial agents in the future. [Extracted from the article]

A study conducted at Ganzhou People's Hospital in Jiangxi, China, focused on the arthroscopic treatment of popliteal cysts through the posterior knee portal. The study analyzed data from 20 patients with symptomatic popliteal cysts who underwent this treatment method. The results showed that all patients had associated intra-articular lesions and were successfully treated, with significant improvement in their scores after surgery and no recurrence of the cysts. The researchers concluded that arthroscopic treatment through the posterior knee portal is a minimally invasive approach that offers benefits such as direct visualization, precise cyst excision, and concurrent treatment of intra-articular pathologies. [Extracted from the article]