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Caffeoylquinic acids, coumarins and dicaffeoyl derivatives are considered to be three kinds of the most abundant bioactive components in Sarcandra glabra, an anti-inflammatory herb mainly found in Southern Asia. The combined anti-inflammatory effect of three typical constituents C + R + I (chlorogenic acid + rosmarinic acid + isofraxidin) from this plant has been investigated. The result implies that targeting the MAPK-NF-κB pathway would be one of the major mechanisms involved, using LPS stimulated RAW 264.7 cells as in vitro model and LPS-induced acute lung injury in mice as in vivo model. C + R + I can significantly suppress the levels of nitric oxide (NO), pro-inflammatory cytokines, and inhibit iNOS and COX-2 expression in LPS-treated RAW264.7 macrophage cells. Western blot analysis showed that C + R + I suppressed phosphorylation of NF-κB and MAPK, including phosphorylation of p65-NF-κB, IKB, ERK, JNK and P38. Besides, C + R + I suppressed MPO protein expression, but promoted SOD and HO-1 expression, and the related targets for C, R, and I were also predicted by molecular docking. This indicated that C + R + I could alleviate oxidative stress induced by LPS, which were further verified in the in vivo model of mice with acute lung injury through the measurement of corresponding inflammatory mediators and the analysis of immunehistochemistry.

Radiation-reaction effects in the interaction of an electron bunch with a superstrong focused ultrashort laser pulse are investigated in the quantum radiation-dominated regime. The angle-resolved Compton scattering spectra are calculated in laser pulses of variable duration using a semiclassical description for the radiation-dominated dynamics and a full quantum treatment for the emitted radiation. In dependence of the laser-pulse duration we find signatures of quantum radiation reaction in the radiation spectra, which are characteristic for the focused laser beam and visible in the qualitative behavior of both the angular spread and the spectral bandwidth of the radiation spectra. The signatures are robust with respect to the variation of the electron and laser-beam parameters in a large range. Qualitatively, they differ fully from those in the classical radiation-reaction regime and are measurable with presently available laser technology. [ABSTRACT FROM AUTHOR]

Objectives: To analyze the risk factors for systemic inflammatory response syndrome (SIRS) after percutaneous nephrolithotomy (PCNL) and to quantitatively predict the probability of SIRS after PCNL. Methods: Medical records on 209 patients who underwent PCNL were retrospectively analyzed. The χ2 test, the t-test and a logistic regression model were used to identify key risk factors of SIRS after PCNL. A predictive equation was then formulated to assess the risk of SIRS according to the results from the logistic model. Subsequently, the accuracy of the equation by calculating sensitivity, specificity, overall correct percentage, and positive and negative predictive values was tested. Results: The incidence of SIRS after PCNL was 23.4%. The key risk factors for SIRS following PCNL were: the number of tracts, receipt of a blood transfusion, stone size, and presence of pyelocaliectasis. Other factors added no independent risk to the development of SIRS. The calculated values for sensitivity, specificity, overall percentage correct, positive predictive value and negative predictive value were 44.9%, 95.0%, 83.3%, 73.3%, and 84.9%, respectively. Conclusions: Number of tracts, receipt of a blood transfusion, stone size and presence of pyelocaliectasis are identified as the key risk factors for SIRS after PCNL. The predictive equation allows for an individualized and quantitative assessment of the probability of SIRS after PCNL. [ABSTRACT FROM AUTHOR]

The effectiveness of silane coupling agents in promoting adhesion in sheath-core fibers was investigated. Polypropylene/rayon and nylon/rayon bicomponent sheath-core fibers were produced by a coating process. The effects of pH. concentration and duration of the pretreatments on adhesion, linear density and tensile properties were measured. When debonding was forced on coupling agent pretreated composite fibers, failure appeared to occur predominantly between the coupling agent and the rayon coating. [ABSTRACT FROM AUTHOR]

Electron acceleration in vacuum induced by a tightly focused chirped laser pulse has been studied. For a fixed laser output power, the tightly focused chirped laser pulse can accelerate electrons to much higher energies. Focusing laser down to the order of wavelength requires inclusion of terms of third order at least in the diffraction angle [variant_greek_epsilon] in the description of the associated field. Retained electron energy depends strongly on frequency chirp parameter and initial position of the electron. Besides, retained energy increases with laser intensity, pulse duration, and initial velocity of electron, and varies periodically with laser constant phase. [ABSTRACT FROM AUTHOR]

The impact of stochasticity effects (SEs) in photon emissions on the proton energy spectra during laser-plasma interaction is theoretically investigated in the quantum radiation-dominated regime. We calculate the photon emissions quantum mechanically and the plasma dynamics semiclassically via two-dimensional particle-in-cell simulations. An ultrarelativistic plasma generated and driven by an ultraintense laser pulse head-on collides with another strong laser pulse, which decelerates the electrons due to radiation-reaction effect and results in a significant compression of the proton energy spectra because of the charge separation force. In the considered regime the SEs are demonstrated in the shift of the mean energy of the protons up to hundreds of MeV. This effect is robust with respect to the laser and target parameters and measurable in soon available strong laser facilities. [ABSTRACT FROM AUTHOR]

The impact of the carrier-envelope phase (CEP) of an intense multicycle laser pulse on the radiation of an electron beam during nonlinear Compton scattering is investigated. We have identified a CEP effect specific to the ultrarelativistic regime. When the electron beam counterpropagates with the laser pulse, pronounced high-energy x-ray double peaks emerge near the backward direction relative to the initial electron motion. This is achieved in the relativistic interaction domain, where both the electron energy is required to be lower than for the electron reflection condition at the laser peak and the stochasticity effects in the photon emission need to be weak. The asymmetry parameter of the double peaks in the angular radiation distribution is shown to serve as a sensitive measure for the CEP of up to 10-cycle long laser pulses and can be applied for the characterization of extremely strong laser pulses in present and near future laser facilities. [ABSTRACT FROM AUTHOR]

Generation of circularly polarized (CP) and linearly polarized (LP) γ rays via the single-shot interaction of an ultraintense laser pulse with a spin-polarized counterpropagating ultrarelativistic electron beam has been investigated in nonlinear Compton scattering in the quantum radiation-dominated regime. For the process simulation, a Monte Carlo method is developed which employs the electron-spin-resolved probabilities for polarized photon emissions. We show efficient ways for the transfer of the electron polarization to the high-energy photon polarization. In particular, multi-GeV CP (LP) γ rays with polarization of up to about 95% can be generated by a longitudinally (transversely) spin-polarized electron beam, with a photon flux meeting the requirements of recent proposals for the vacuum birefringence measurement in ultrastrong laser fields. Such high-energy, high-brilliance, high-polarization γ rays are also beneficial for other applications in high-energy physics, and laboratory astrophysics. [ABSTRACT FROM AUTHOR]

Spin polarization of an ultrarelativistic electron beam head-on colliding with an ultraintense laser pulse is investigated in the quantum radiation-dominated regime. We develop a Monte Carlo method to model electron radiative spin effects in arbitrary electromagnetic fields by employing spin-resolved radiation probabilities in the local constant field approximation. Because of spin-dependent radiation reaction, the applied elliptically polarized laser pulse polarizes the initially unpolarized electron beam and splits it along the propagation direction into two oppositely transversely polarized parts with a splitting angle of about tens of milliradians. Thus, a dense electron beam with above 70% polarization can be generated in tensof femtoseconds with realistic laser pulses. The proposed method demonstrates a way for relativistic electron beam polarization with currently achievable laser facilities. [ABSTRACT FROM AUTHOR]