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To investigate the role of intercellular adhesion molecule-1 (ICAM-1) in the accumulation of polymorphonuclear neutrophils (PMN) in the lungs at the early stage of burns.Myeloperoxidase content in lung tissues and bronchoalveolar lavage fluid (BALF) were detected. ICAM-1 and its mRNA expression in lung tissues were determined by immunohistochemical method and in situ hybridization. CD11b/CD18 expression on the peripheral PMNs was measured by flow cytometry.The levels of myeloperoxidase in lung tissues and BALF after burn injury were markedly higher than those of control. Expression of ICAM-1 and its mRNA in the lung tissues and CD11b/CD18 on peripheral PMNs surface was significantly increased at 2, 6, 12, 24 h after burns.PMNs accumulation in the lungs is related to increased ICAM-1 expression on pulmonary microvascular endothelial cells and CD11b/CD18 expression on PMN at the early stage of burn injury.

According data provided by China Traffic Management Bureau showed that the traffic crashes and traffic injuries were triumphantly controlled and decreased remarkably year by year since 2003, as suggests that the safety precautions have gotten great durative effects and have gotten a lot of successful experiences after China Road Traffic Safety Act brought into effect in 2004. We have carried out some in-depth investigation to some areas of China and found that China traffic safety situation was still not as good as the announcement data. Although number and the casualties of traffic crashes have not continued to increase rapidly again, but the number of traffic crashes still maintained at a high level. Through careful comparison, the author found that China9s current traffic and traffic injuries in the calculation of statistics and reporting requirements and mechanisms were different from the international9s, which has led to the huge differences, and that is disadvantage for the Chinese transportation injury9s prevention and the control. This article has carried on the analysis discussion on these data and the problems

A simple and sensitive reversed-phase liquid chromatographic method has been developed and validated for the analysis of captopril in human plasma and the study of the pharmacokinetics of the drug in human body. Captopril was stabilized by forming an adduct with p-bromophenacyl bromide. The adduct formed and 4-chloro-2-nitroaniline (internal standard) were extracted with ethyl acetate:benzene (1:1), and then measured by HPLC using a Spherisorb C18 column as stationary phase and a water:acetonitrile:acetic acid mixture (44:55:0.2, v/v/v) as mobile phase. Captopril was quantified by absorbance at 258 nm. The method proved to be linear in the clinical range of 5-500 ng/mL. The lower limit of detection of captopril in plasma was 2 ng/mL. Intra-day and inter-day coefficients of variation of assay for captopril in plasma were 5.8%-8.5% (n = 7) and 8.0%-9.5% (n = 5), respectively. The recoveries of captopril were 90%-98% for plasma. The data obtained was fitted with 3P87 program on computer to study the pharmacokinetics. The results showed that the disposition of captopril was conformed to a two-compartment open model with Tmax = 0.56 h, Cmax = 266.5 ng/mL and AUC(zero)-infinity = 380.3 ng.h/mL. The method has been used to determine captopril in plasma samples from ten volunteers and provided data on the pharmacokinetics of the drug. The results inferred that captopril is absorbed rapidly and had a relatively short half-life time in healthy individuals.

Background In recent 30 years, Chinese road traffic injuries increased dramatically with the rapid development of traffic and transportation. Domestic and foreign researches mostly hold certain views and arguments on the data of Chinese road traffic injuries. Objectives To analyse the differences and causes between Chinese official data of road traffic injuries and the reality to promote the control on Chinese road traffic injuries through the surveys on road traffic accidents and injuries. Methods (1) Sampling survey was made on the original files of all road traffic accidents of three traffic police management sub-groups of a city in 2000-2006 to investigate accidents, casualties, time of death, etc as well as the data of accidents and deaths reported and released every year, etc and analyse whether there are significant differences between the data of original accident files and the data released; (2) the data and information about the inpatients due to wounds and traffic injuries from 210 Chinese hospitals in 2001-2007 were chosen to analyse the casualties and trends of traffic injured persons hospitalised. Results The regional road traffic accidents and injuries and the number of inpatients with traffic injuries to be treated by hospitals tend to increase slowly as a whole. The results of sampling survey shows that the actual number of deaths due to traffic accidents of a city between 2000-2006 is 3.09 times of the released one, resulting in a data loss rate of 67.62%, while the data loss rate in the rural-urban fringe zone is even up to 89.93%; the number of injured persons is 5.59 times of the one released by public security department, resulting in a data loss rate of 82.10%, while the data loss rate in rural-urban fringe zone is even up to 95.73%. 13.21% of these deaths due to traffic accidents have ever been injured for 7 days before death; 26.71% of the deaths due to traffic accidents after being hospitalised have ever been injured for 7 days before death. Conclusions The results of the research suggest that, the rapid and continuous increase of Chinese road traffic injuries was controlled effectively between 2000-2007 as we researched, but there was no significant drop either; the numbers of deaths and injured persons due to traffic accidents in the region surveyed are above three times and five times of those released by police system respectively, the reasons for which involves the statistical standards and methods of Chinese traffic accidents and casualties and the management mechanism of police system, etc. The reasons were discussed and some suggestions were given in this paper. This is an abstract of a presentation at Safety 2012, the 11th World Conference on Injury Prevention and Safety Promotion, 1-4 October 2012, Michael Fowler Center, Wellington, New Zealand. Full text does not seem to be available for this abstract.