Author: "Jean-Olivier Durand" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Jean-Olivier Durand"' showing total 181 results

Start Over Author "Jean-Olivier Durand"

181 results on '"Jean-Olivier Durand"'

101. [Untitled]

Author: P. Parent, Jean-Olivier Durand, J Olivier-Fourcade, J.-C Jumas, and M. Womes
Subjects: Ternary numeral system, Materials science, Extended X-ray absorption fine structure, Mechanical Engineering, Analytical chemistry, Mineralogy, chemistry.chemical_element, Amplitude, Antimony, chemistry, Mechanics of Materials, Phase (matter), Thallium, General Materials Science, Arsenic, Phase diagram
Abstract: The local environment of arsenic atoms in vitreous samples of the system Sb2S3–As2S3–Tl2S has been studied by EXAFS at the AsK-edge. The crystalline compound Tl5.6As15S25.3 situated within the zone of glass formation of the Sb2S3–As2S3–Tl2S phase diagram was used as reference compound in order to derive appropriate phase and amplitude functions. The structure parameters determined were the number of first neighbours N As–S, the arsenic-sulphur distance, R As–S, and the Debye-Waller factor, σAs–S. The influence of the glass-forming antimony sulphide Sb2S3 and the glass-modifying thallium sulphide Tl2S on the As2S3 host matrix has been shown.
Published: 1997
Full Text: View/download PDF

102. Synthesis of 3-fluoro azetidinone by electrophilic fluorination

Author: Sylvain Roland, Jean-Pierre Genêt, F. Jung, Monique Savignac, and Jean-Olivier Durand
Subjects: Chemistry, Yield (chemistry), Organic Chemistry, Drug Discovery, Electrophilic fluorination, Organic chemistry, Biochemistry
Abstract: An easy access to the 3-fluoroazetidinone 4a based on electrophilic fluorination, is reported. The fluorination of the β-lactam 7 with Differding's N-fluorosulfonimide proceeds stereoselectively, under mild conditions and in good yield.
Published: 1997
Full Text: View/download PDF

103. Two-Photon-Triggered Drug Delivery in Cancer Cells Using Nanoimpellers

Author: Jean-Olivier Durand, Marie Maynadier, Laurence Raehm, Jeffrey I. Zink, Jeff L. Nyalosaso, Mireille Blanchard-Desce, Magali Gary-Bobo, Marcel Garcia, Audrey Gallud, Olivier Mongin, Jie Lu, Harmel Peindy N'Dongo, Nathalie Cheminet, Derrick Tarn, Clarence Charnay, Françoise Serein-Spirau, Thibaut Jarrosson, Tania M. Guardado-Alvarez, Jonas G. Croissant, Gaelle Derrien, Fuyuhiko Tamanoi, Chemical and Biological Engineering [Albuquerque], The University of New Mexico [Albuquerque], Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Clermont-Ferrand - Clermont Auvergne (ICCF), Sigma CLERMONT (Sigma CLERMONT)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Synthèse et électrosynthèse organiques (SESO), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1), Department of Chemistry, Massachusetts Institute of Technology (MIT), Microbiology, Immunology and Molecular Genetics (UCLA), University of California [Los Angeles] (UCLA), University of California-University of California, Department of Chemistry and Biochemistry, Exotic Materials Institute, University of California, Los Angeles (UCLA), Department of Chemistry and Biochemistry, University of California Los Angeles, Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University of California (UC)-University of California (UC), ANR-10-NANO-0022,MECHANANO,Nanomachines mécanisées pour l'activation à deux photons(2010), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Institut des Sciences Chimiques de Rennes (ISCR), Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Rennes-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), Chimie et Photonique Moléculaires (CPM), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Centre National de la Recherche Scientifique (CNRS), Nyalosaso, Jeff, and NANOTECHNOLOGIES ET NANOSYSTEMES - Nanomachines mécanisées pour l'activation à deux photons - - MECHANANO2010 - ANR-10-NANO-0022 - P2N - VALID
Subjects: Fluorophore, Stereochemistry, [CHIM.THER] Chemical Sciences/Medicinal Chemistry, [SDV.CAN]Life Sciences [q-bio]/Cancer, 02 engineering and technology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, mesoporous materials, 010402 general chemistry, 01 natural sciences, Catalysis, Article, chemistry.chemical_compound, Drug Delivery Systems, Two-photon excitation microscopy, [SDV.CAN] Life Sciences [q-bio]/Cancer, Neoplasms, medicine, cancer, Humans, ComputingMilieux_MISCELLANEOUS, [CHIM.MATE] Chemical Sciences/Material chemistry, two-photon excitation, Chemistry, 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Cancer, General Chemistry, General Medicine, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, medicine.disease, [CHIM.ORGA] Chemical Sciences/Organic chemistry, 0104 chemical sciences, 3. Good health, Förster resonance energy transfer, azobenzene, Azobenzene, Drug delivery, Cancer cell, drug delivery, Biophysics, Nanoparticles, 0210 nano-technology, Azo Compounds, Camptothecin, medicine.drug
Abstract: International audience; A therapy of cancer cells: Two-photon-triggered camptothecin delivery (see picture) with nanoimpellers was studied in MCF-7 breast cancer cells. A fluorophore with a high two-photon absorption cross-section was first incorporated in the nanoimpellers. Fluorescence resonance energy transfer (FRET) from the fluorophore to the azobenzene moiety was demonstrated.
Published: 2013
Full Text: View/download PDF

104. Anionic porphyrin-grafted porous silicon nanoparticles for photodynamic therapy

Author: Jean-Olivier Durand, Magali Gary-Bobo, Frédérique Cunin, Marie Maynadier, Emilie Secret, Marcel Garcia, Arnaud Chaix, Michael J. Sailor, Philippe Maillard, Emmanuel Belamie, Audrey Gallud, Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Department of Chemistry and Biochemistry, University of California [San Diego] (UC San Diego), and University of California-University of California
Subjects: Anions, Silicon, Materials science, Porphyrins, medicine.medical_treatment, Nanoparticle, Photodynamic therapy, Breast Neoplasms, 02 engineering and technology, 010402 general chemistry, Porous silicon, Photochemistry, 01 natural sciences, Catalysis, chemistry.chemical_compound, Materials Chemistry, medicine, Humans, ComputingMilieux_MISCELLANEOUS, Photosensitizing Agents, technology, industry, and agriculture, Metals and Alloys, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, equipment and supplies, 021001 nanoscience & nanotechnology, Porphyrin, 3. Good health, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry, Photochemotherapy, Covalent bond, Ceramics and Composites, MCF-7 Cells, Nanoparticles, Female, Breast cancer cells, 0210 nano-technology, Porosity
Abstract: Non-toxic porous silicon nanoparticles carry porphyrin covalently attached to their surface inside breast cancer cells for a more efficient photodynamic effect.
Published: 2013
Full Text: View/download PDF

105. K edge absorption spectra of sulphur in vapour, molecular and polymerized solid phases

Author: Josette Olivier-Fourcade, R C Karnatak, J M Esteva, M. Womes, A Elafif, Cristian M. Teodorescu, Jean-Claude Jumas, and Jean-Olivier Durand
Subjects: inorganic chemicals, Physics, Absorption spectroscopy, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Spectral line, Crystallography, K-edge, Covalent bond, Phase (matter), Atom, Molecule, Atomic physics, Lone pair
Abstract: X-ray K absorption spectra of sulphur have been studied in its vapour, molecular and polymerized solid phases. The vapour phase of sulphur containing molecules yields a K spectrum which is similar to that of the molecule. This observation suggests a ground state of , which is in agreement with that obtained from optical spectra. Different line splittings in the spectra of these molecules are discussed in the light of the p orbital and s - p orbital energy differences of some second- and third-period elements. While the condensed phase spectrum of remains unchanged, the observed K spectrum of condensed differs considerably from its vapour phase. This abrupt change in the bonding between the S atoms in the condensed phase is typical behaviour of sulphur and indicates the formation of two directional covalent bonds and creation of and lone pairs. This behaviour is, in fact, a clear distinction between the chemistries of sulphur and that of its homologue oxygen. The cyclic and chain forms of sulphur show some similarity in line structure and a marked difference in their near-edge structure due to a different number of S atoms surrounding a central atom in these allotropic forms.
Published: 1996
Full Text: View/download PDF

106. Sulfur K-edge XAS study of As2S3Sb2S3Tl2S glasses

Author: Josette Olivier-Fourcade, Pierre-Emmanuel Lippens, M. Womes, Jean-Olivier Durand, and Jean-Claude Jumas
Subjects: chemistry.chemical_classification, X-ray absorption spectroscopy, Sulfide, Inorganic chemistry, Analytical chemistry, chemistry.chemical_element, Condensed Matter Physics, Sulfur, Electronic, Optical and Magnetic Materials, Amorphous solid, Bond length, Antimony, chemistry, Chemical bond, Materials Chemistry, Ceramics and Composites, Arsenic sulfide
Abstract: The local environment of sulfur in amorphous As2S3Sb2S3Tl2S was studied by XAS at the sulfur K-edge. Variations in shape and position of the white line are attributed to changes in the nature of the chemical bond, the metalsulfur bond lengths, and the homogeneity of the metalsulfur bond length distribution. The variations of the white line parameters, position and line width, with sample composition reveal the different influences of the glass-forming arsenic sulfide and antimony sulfide and the glass modifying thallium sulfide.
Published: 1996
Full Text: View/download PDF

107. Far infrared transmission study of the ternary system Sb2S3As2S3Tl2S

Author: Josette Olivier-Fourcade, Jean-Claude Jumas, M.A. El Idrissi-Raghni, B. Bonnet, Jean-Olivier Durand, and L. Hafid
Subjects: chemistry.chemical_classification, X-ray absorption spectroscopy, Sulfide, Mechanical Engineering, Inorganic chemistry, Metals and Alloys, Infrared spectroscopy, chemistry.chemical_element, Amorphous solid, Far infrared, Antimony, chemistry, Mechanics of Materials, Materials Chemistry, Arsenic sulfide, Arsenic
Abstract: The local environment of metal (arsenic and antimony) atoms in amorphous samples of the ternary system As 2 S 3 Sb 2 S 3 Tl 2 S has been studied by far infrared transmission spectroscopy. Variations in shape and position of observed bands are attributed to changes in the nature of the coordination patterns of the arsenic and antimony atoms. The variations reveal the different influences of the glass forming arsenic sulfide and antimony sulfide and the glass modifying thallium sulfide on the respective host matrices. The results presented here confirm the hypotheses established previously on the basis of studies of this system by EXAFS at the arsenic K-edge and by XAS at the sulfur K- and antimony L III -edges.
Published: 1996
Full Text: View/download PDF

108. Bithiocamphor: an interesting synthon for the synthesis of chiral ligands

Author: Murielle Bonnat, Jean-Olivier Durand, and Maurice Le Corre
Subjects: Inorganic Chemistry, Reduction (complexity), Chemistry, Organic Chemistry, Synthon, Organic chemistry, Physical and Theoretical Chemistry, Combinatorial chemistry, Catalysis
Abstract: Bithiocamphor 1 was studied; its reduction led to dithiols 3a and 3b , its oxidation led to bicamphor 8 .
Published: 1996
Full Text: View/download PDF

109. Sb LIII-edge XAS study of the ternary system Sb2S3As2S3Tl2S

Author: Pierre-Emmanuel Lippens, Jean-Claude Jumas, Josette Olivier-Fourcade, M. Womes, and Jean-Olivier Durand
Subjects: X-ray absorption spectroscopy, Extended X-ray absorption fine structure, Absorption spectroscopy, Chemistry, Inorganic chemistry, Analytical chemistry, chemistry.chemical_element, Condensed Matter Physics, XANES, Electronic, Optical and Magnetic Materials, X-ray absorption fine structure, Antimony, Materials Chemistry, Ceramics and Composites, Absorption (electromagnetic radiation), Phase diagram
Abstract: The local environment of antimony atoms in glassy samples of the system Sb2S3As2S3Tl2S is studied by X-ray absorption spectroscopy at the Sb LIII-edge. The crystalline compound TlSb3S5, situated within the zone of glass formation of the Sb2S3As2S3Tl2S phase diagram, is used as reference compound in order to derive appropriate phase and amplitude functions for the extended X-ray absorption fine structure (EXAFS) study. The limits of EXAFS in studying the local order around antimony in compounds with complex structure are discussed. The possibilities of a combined application of EXAFS, X-ray absorption near edge structure and 121Sb Mossbauer spectroscopy to the study of these compounds are shown. The results are discussed in terms of a model of random substitution of arsenic by antimony.
Published: 1996
Full Text: View/download PDF

110. Triisopropoxysilyl-functionalized oxide nanoparticles using a di-tert-butyl phosphonate ester as the surface grafting agent

Author: Richard Frantz, Gérard F. Lanneau, Michel Granier, and Jean-Olivier Durand
Subjects: Tert butyl, Organic Chemistry, Oxide, Nanoparticle, Grafting, Biochemistry, Phosphonate, chemistry.chemical_compound, chemistry, Reagent, Drug Discovery, Polymer chemistry, Organic chemistry, Reactivity (chemistry), Bifunctional
Abstract: The synthesis of a bifunctional coupling reagent possessing a triisopropoxysilyl group and a tert -butyl phosphonate ester is described. The tert -butyl phosphonate ester was used as an efficient and selective grafting reagent for the anchoring of the triisopropoxysilyl group at the surface of TiO 2 and SnO 2 nanoparticles under mild conditions. The triisopropoxysilyl group remained intact and did not react at the surface of the oxide nanoparticles. The reactivity of the triisopropoxysilyl group was then further investigated.
Published: 2004
Full Text: View/download PDF

111. Mannose-functionalized porous silica-coated magnetic nanoparticles for two-photon imaging or PDT of cancer cells

Author: Marine Perrier, Philippe Maillard, Jean-Olivier Durand, Marcel Garcia, Yannick Guari, Mireille Blanchard-Desce, Magali Gary-Bobo, Olivier Mongin, Laurence Raehm, Joulia Larionova, Lenaic Lartigue, Alain Morère, David Brevet, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Conception, synthèse et vectorisation de biomolécules. (CSVB), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes-Centre National de la Recherche Scientifique (CNRS), and Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Fluorophore, Materials science, Mannose, Nanoparticle, Bioengineering, Nanotechnology, 02 engineering and technology, 010402 general chemistry, Photochemistry, 01 natural sciences, Photodynamic therapy, chemistry.chemical_compound, Moiety, General Materials Science, Photosensitizer, Two-photon imaging, [CHIM.ORGA]Chemical Sciences/Organic chemistry, General Chemistry, Mesoporous silica, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Porphyrin, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, chemistry, Modeling and Simulation, Magnetic nanoparticles, 0210 nano-technology
Abstract: International audience; An original fluorophore engineered for two-photon excitation or a porphyrin derivative were entrapped in the silica shell of magnetic porous silica nanoparticles during the synthesis of the silica moiety without damaging the structure of the organic part. The mild conditions involved allowed obtaining microporous or mesoporous silica magnetic nanoparticles, respectively. Mannose was grafted on the surface of the nanoparticles to target MCF-7 breast cancer cells. The studies of magnetic properties of these hybrid nanoparticles showthat they present a blocking temperature at 190 K. The nano-objects designed with the twophoton fluorophore were efficient for two-photon imaging of MCF-7 cancer cells, whereas the nanoobjects with the photosensitizer efficiently killed cancer cells. The presence of the mannose moiety was demonstrated to improve both imaging and therapy properties.
Published: 2013
Full Text: View/download PDF

112. A structural study of glasses in the As2S3Sb2S3Tl2S system

Author: Jean-Claude Jumas, Jean-Olivier Durand, Pierre-Emmanuel Lippens, and Josette Olivier-Fourcade
Subjects: S system, Extended X-ray absorption fine structure, chemistry.chemical_element, Condensed Matter Physics, Sulfur, Local structure, Electronic, Optical and Magnetic Materials, Crystallography, Differential scanning calorimetry, chemistry, K-edge, Materials Chemistry, Ceramics and Composites, Absorption (chemistry), Glass transition
Abstract: The local structure around As for glasses in the system As 2 S 3 Sb 2 S 3 Tl 2 S has been studied by measuring the extended X-ray absorption fine structure (EXAFS) at the As K edge and by differential scanning calorimetry. The variation of the EXAFS parameters and of the glass transition temperature as a function of the Sb 2 S 3 concentration has been analyzed for three systems containing 0, 20 and 40 mol% Tl 2 S. For all the glasses, As is found to be surrounded by 3 ± 0.2 sulfur atoms. The main trends in the variation of the average AsS interatomic distance and the Debye-Waller factor are explained in terms of a simple structural model involving AsS 3 and SbS 3 pyramidal units. The pyramids are linked by the S atoms (bridging sulfur atoms) or are not linked (non-bridging sulfur atoms) depending on the Tl 2 S content. The effect of the addition of Tl 2 S has been confirmed by a study of glasses in the As 2 S 3 Tl 2 S system.
Published: 1995
Full Text: View/download PDF

113. X-ray absorption and Mössbauer study of the CeSb-CeTe system

Author: Jean-Claude Jumas, Jean-Olivier Durand, A. Percheron-Guégan, P. Parent, Guido Langouche, M.L. Elidrissi Moubtassim, D. Ravot, and Josette Olivier-Fourcade
Subjects: Mössbauer effect, Condensed matter physics, Chemistry, Mechanical Engineering, Metals and Alloys, Electron, Magnetic field, Chemical bond, Mechanics of Materials, Mössbauer spectroscopy, Materials Chemistry, Absorption (electromagnetic radiation), Mixing (physics), Solid solution
Abstract: CeSb is a cubic trivalent Ce compound. Its very abnormal magnetic diagram contains 16 different phases depending on magnetic field and temperature. These complex physical properties could be interpreted in the framework of the p-f mixing model based on a strong mixing interaction between 4f electrons and p-band holes. The substitution of Sb by the less electronegative element Te, filling the p-valence band, modifies the hole concentration and yields very important effects. Thus, the study of the Ce(Te)Sb system is a good tool to check the validity of the model. In this paper we present a study of the CeSb1 − xTex solid solution by X-ray absorption experiments at the Ce and Sb L111 edge and by Mossbauer spectroscopy (121Sb, 125Te). From these results, the evolution of the nature of the chemical bonding under substitution is discussed, in correlation with the x-dependence of the electronic and magnetic properties.
Published: 1995
Full Text: View/download PDF

114. π-Allyl palladium ring closure strategy for the synthesis of a 1β-methylcarbapenem intermediate

Author: Jean Olivier Durand, S. Roland, Monique Savignac, Frederic Henri Jung, and Jean Pierre Genêt
Subjects: Chemistry, Yield (chemistry), Organic Chemistry, Drug Discovery, Closure (topology), chemistry.chemical_element, Nanotechnology, Ring (chemistry), Biochemistry, Medicinal chemistry, Palladium catalyst, Palladium
Abstract: A new ring closure by π-allyl palladium methodology is utilized in the synthesis of a 1-β-methyl carbapenem intermediate from 2-acetoxy azetidinone in six steps (40% yield).
Published: 1995
Full Text: View/download PDF

115. COCHO-modified oxides nanoparticles by using phosphonic acid as grafting agent

Author: Michel Granier, Oleg Melnyk, Samiran Kar, Jean-Olivier Durand, and Pascal Joly
Subjects: Chemistry, Organic Chemistry, Nanoparticle, Grafting, Cleavage (embryo), Biochemistry, Metal, chemistry.chemical_compound, Hydroxylamine, visual_art, Heck reaction, Drug Discovery, Polymer chemistry, visual_art.visual_art_medium, Organic chemistry, Reactivity (chemistry), Dithiane
Abstract: The synthesis of phosphonic acid 4 possessing a protected COCHO group, by using the Heck reaction is described. After grafting of the phosphonic acid 4 on metal oxides Al 2 O 3 , TiO 2 or SnO 2 , the cleavage of the dithiane group was successful. The reactivity of the supported-COCHO group was examined by using model reactions with hydroxylamine and hydrazine derivatives.
Published: 2003
Full Text: View/download PDF

116. Antibody-Functionalized Porous Silicon Nanoparticles for Vectorization of Hydrophobic Drugs

Author: Kevin S. Smith, Emilie Secret, Bahman Delalat, Frédérique Cunin, Nicolas H. Voelcker, Mary-Louise Rogers, Eli Moore, Valentina Dubljevic, Jean-Olivier Durand, Peter J. Macardle, Terrance Grant Johns, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Secret, Emilie, Smith, Kevin, Dubljevic, Valentina, Moore, Eli, Macardle, Peter, Delalat, Bahman, Rogers, Mary-Louise, Johns, Terrance G, Durand, Jean-Olivier, Cunin, Frédérique, and Voelcker, Nicolas H
Subjects: neoplasms, Pharmaceutical Science, 02 engineering and technology, 01 natural sciences, Diffusion, Materials Testing, antineoplastic agents, antibodies, ComputingMilieux_MISCELLANEOUS, medicine.diagnostic_test, diffusion, nanocapsules, Antibodies, Monoclonal, cell line, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 3. Good health, Treatment Outcome, Drug delivery, 0210 nano-technology, Hydrophobic and Hydrophilic Interactions, Porosity, medicine.drug, Silicon, Materials science, porosity, Immunocytochemistry, Biomedical Engineering, 010402 general chemistry, Flow cytometry, Biomaterials, Nanocapsules, Cell Line, Tumor, medicine, Animals, Humans, Viability assay, materials testing, Bioconjugation, camptothecin, Neoplasms, Experimental, silicon/chemistry, Antineoplastic Agents, Phytogenic, Molecular biology, 0104 chemical sciences, hydrophobic and hydrophilic interactions, Cell culture, Cancer cell, Biophysics, Camptothecin
Abstract: We describe the preparation of biodegradable porous silicon nanoparticles (pSiNP) functionalized with cancer cell targeting antibodies and loaded with the hydrophobic anti-cancer drug camptothecin. Orientated immobilization of the antibody on the pSiNP is achieved using novel semicarbazide based bioconjugate chemistry. To demonstrate the generality of this targeting approach, the three antibodies MLR2, mAb528 and Rituximab are used, which target neuroblastoma, glioblastoma and B lymphoma cells, respectively. Successful targeting is demonstrated by means of flow cytometry and immunocytochemistry both with cell lines and primary cells. Cell viability assays after incubation with pSiNPs show selective killing of cells expressing the receptor corresponding to the antibody attached on the pSiNP. Refereed/Peer-reviewed
Published: 2012
Full Text: View/download PDF

117. Tunable Multifunctional Mesoporous Silica Microdots Arrays by Combination of Inkjet Printing, EISA, and Click Chemistry

Author: François Ribot, Xavier Cattoën, Claire Carrion, B. Fousseret, Fabrice Rossignol, Clément Sanchez, Martine Lejeune, Olivia de los Cobos, Cédric Boissière, Maggy Dutreilh-Colas, Michel Wong Chi Man, Jean-Olivier Durand, Axe 1 : procédés céramiques, Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Axe 3 : organisation structurale multiéchelle des matériaux (SPCTS-AXE3), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM), Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations (PMRIL), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Centre National de la Recherche Scientifique (CNRS), Chaire Chimie des matériaux hybrides, Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), and Thèse en collaboration
Subjects: Materials science, General Chemical Engineering, Nanotechnology, 02 engineering and technology, Substrate (printing), 010402 general chemistry, 01 natural sciences, Micelle, chemistry.chemical_compound, fluorescent probes, Materials Chemistry, mesoporous silica, Porosity, inkjet printing, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, Mesoporous silica, Propargyl alcohol, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, Triethoxysilane, click chemistry, Click chemistry, Azide, 0210 nano-technology
Abstract: 6 pages; International audience; A novel technique combining inkjet printing (IJP), evaporation-induced self-assembly (EISA), and click chemistry is implemented for elaborating mesoporous silica-based multifunctional microdots arrays. The microdots are in situ azide-functionalized with (3-azidopropyl)triethoxysilane (AzPTES). AzPTES is directly added to the initial sol before IJP and co-condenses with the silica precursor (TEOS) during the evaporation-induced self-assembly (EISA) of micelles on the substrate. After extracting the surfactants to release the porosity, model alkynes, namely propargyl alcohol, methyl pent-4-ynoate, ethynylferrocene, and N-propargyl-4-amino-1,8-naphthalimide, are grafted by the azide−alkyne CuAAC click reaction. The demonstration is established that the click reaction is nearly quantitative and occurs in the whole volume of the microdots attesting the accessibility of the azide groups. By integrating an alkyne-containing silylated precursor in a similar route, azide-containing functional groups are anchored in the microdots by click reaction. A demonstration of the multifunctionalization of such microdots arrays is achieved by reacting clickable dyes on alternate alkyne- and azide- functionalized lines of microdots, as evidenced by confocal fluorescence microscopy. Such multifunctional mesoporous silica microdots arrays offer promising perspectives for biosensing applications.
Published: 2012
Full Text: View/download PDF

118. Non polymeric nanoparticles for photodynamic therapy applications: recent developments

Author: Régis Vanderesse, Jean-Olivier Durand, Hamanou Benachour, Céline Frochot, Marc Verelst, Sébastien Richeter, Muriel Barberi-Heyob, Aymeric Sève, Rima Chouikrat, Laurence Raehm, Laboratoire Réactions et Génie des Procédés (LRGP), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Centre d'élaboration de matériaux et d'études structurales (CEMES), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Laboratoire de Chimie Physique Macromoléculaire (LCPM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Centre de Recherche en Automatique de Nancy (CRAN), Université Henri Poincaré - Nancy 1 (UHP)-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Centre Alexis Vautrin (CAV), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: photosensitizer, medicine.medical_treatment, Nanotechnology, Photodynamic therapy, 02 engineering and technology, 010402 general chemistry, chemotherapy, 01 natural sciences, Biochemistry, Magnetics, Nanoparticle, Drug Discovery, medicine, Animals, Humans, cancer, Photosensitizer, radiotherapy, Pharmacology, Titanium, reactive oxygen species, Photosensitizing Agents, Chemistry, Nanotubes, Carbon, nanoplatforms, Organic Chemistry, Cancer, 021001 nanoscience & nanotechnology, Polymeric nanoparticles, medicine.disease, Silicon Dioxide, nanomedicine, polymeric, 3. Good health, 0104 chemical sciences, Cancer treatment, Radiation therapy, Photochemotherapy, photodynamic therapy, Molecular Medicine, Nanomedicine, Nanoparticles, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Gold, Zinc Oxide, 0210 nano-technology
Abstract: International audience; Photodynamic therapy has emerged as an alternative to chemotherapy and radiotherapy for cancer treatment. Nanoparticles have recently been proposed as effective carriers for photosensitizers. Depending on their chemical composition, these can be used for diagnosis and therapy due to the selective accumulation of the photosensitizer in cancer cells in vitro or in tumors in vivo. Multifunctional nanoplatforms combining several applications within the same nano-object emerge as potential important theranostic tools. This review, based on the chemical nature of the nanoparticles will discuss recent advances in the area of non polymeric nanoparticles for photodynamic therapy applications.
Published: 2012
Full Text: View/download PDF

119. Cancer Therapy Improvement with Mesoporous Silica Nanoparticles Combining Targeting, Drug Delivery and PDT

Author: Magali Gary-Bobo, Virginie Charasson, Jean-Olivier Durand, Philippe Maillard, David Brevet, Sébastien Richeter, Marcel Garcia, Bernard Loock, Ouahiba Hocine, Alain Morère, Marie Maynadier, Laurence Raehm, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Conception, synthèse et vectorisation de biomolécules. (CSVB), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)
Subjects: animal structures, Time Factors, medicine.medical_treatment, Chemistry, Pharmaceutical, Drug Compounding, Pharmaceutical Science, Photodynamic therapy, Receptors, Cell Surface, 02 engineering and technology, Endosomes, 010402 general chemistry, 01 natural sciences, law.invention, Confocal microscopy, law, Neoplasms, medicine, Humans, Nanotechnology, Technology, Pharmaceutical, Photosensitizer, ComputingMilieux_MISCELLANEOUS, Drug Carriers, Microscopy, Confocal, Photosensitizing Agents, Cell Death, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Galactose, Mesoporous silica, 021001 nanoscience & nanotechnology, HCT116 Cells, Silicon Dioxide, 0104 chemical sciences, 3. Good health, Biochemistry, Photochemotherapy, Cancer cell, Drug delivery, Biophysics, Nanoparticles, Fluorescein, sense organs, 0210 nano-technology, Drug carrier, Lysosomes, Porosity, Camptothecin, medicine.drug
Abstract: The synthesis of mesoporous silica nanoparticles (MSN) covalently encapsulating fluoresceine or a photosensitizer, functionalized with galactose on the surface is described. Confocal microscopy experiments demonstrated that the uptake of galactose-functionalized MSN by colorectal cancer cells was mediated by galactose receptors leading to the accumulation of the nanoparticles in the endosomal and lysosomal compartments. The MSN functionalized with a photosensitizer and galactose were loaded with the anti-cancer drug camptothecin. Those MSN combining drug delivery and photodynamic therapy were tested on three cancer cell lines and showed a dramatic enhancement of cancer cell death compared to separate treatments.
Published: 2012
Full Text: View/download PDF

120. Silica nanoparticles pre-spotted onto target plate for laser desorption/ionization mass spectrometry analyses of peptides

Author: Jean-Olivier Durand, Jean Martinez, Sonia Cantel, Christine Enjalbal, Mathieu Dupré, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: MALDI imaging, Analyte, Analytical chemistry, Signal-To-Noise Ratio, 010402 general chemistry, 01 natural sciences, Biochemistry, Mass Spectrometry, Analytical Chemistry, Matrix (chemical analysis), Tandem Mass Spectrometry, Desorption, Environmental Chemistry, Deposition (phase transition), Animals, Sample preparation, Trypsin, Amino Acid Sequence, Spectroscopy, ComputingMilieux_MISCELLANEOUS, Chromatography, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Lasers, 010401 analytical chemistry, Reproducibility of Results, Repeatability, Silicon Dioxide, 0104 chemical sciences, Proteolysis, Nanoparticles, Cattle, Dispersion (chemistry), Peptides
Abstract: We report on the simple deposition of Stober silica nanoparticles (SiO 2 NPs) on conventional MALDI target plate for high throughput laser desorption/ionization mass spectrometry (LDI-MS) analyses of peptide mixtures with sensitivity in the femtomolar range. This low-cost easily prepared material allowed straightforward LDI experiments by deposition of the studied samples directly onto a pre-spotted MALDI plate. This analytical strategy can be performed in any laboratory equipped with a MALDI-TOF instrument. All key benefits of organic matrix-free technologies were satisfied while maintaining a high level of detection performances (sensitivity and reproducibility/repeatability). In particular, sample preparation was simple and detection in the low mass range was not hampered by matrix ions. Imaging studies were undertaken to query sample dispersion into the inert SiO 2 NPs and to help into the search of the best experimental conditions producing homogeneous analyte distribution within the deposit. In contrast to commercial disposable LDI targets designed for single use and requiring an adaptor such as NALDI™, the proposed SiO 2 NPs pre-spotting on a MALDI target plate allowed very easily switching between MALDI and LDI experiments. They can be conducted either simultaneously (positions with an organic matrix or SiO 2 NPs) or in the row (support prepared in advance, stored and washed after use). The overall cost and versatility of the methodology made it very attractive to MALDI users in many domains (peptidomics, proteomics, metabolomics).
Published: 2012
Full Text: View/download PDF

121. Multifunctionalized mesoporous silica nanoparticles for the in vitro treatment of retinoblastoma: Drug delivery, one and two-photon photodynamic therapy

Author: Audrey Gallud, Marie Maynadier, David Brevet, Alain Morère, Youssef Mir, Cédric Rouxel, Ouahiba Hocine, Magali Gary-Bobo, Olivier Mongin, Afitz Da Silva, Jean-Olivier Durand, Mireille Blanchard-Desce, Philippe Maillard, Bernard Loock, Laurence Raehm, Marcel Garcia, Sébastien Richeter, Laboratoire d'Aquaculture tropicale, Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Chimie et Photonique Moléculaires (CPM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Conception, synthèse et vectorisation de biomolécules. (CSVB), Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université Paul-Valéry - Montpellier 3 (UM3), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Université Paul-Valéry - Montpellier 3 (UPVM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut de Recherche pour le Développement (IRD [France-Sud]), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Paul-Valéry - Montpellier 3 (UPVM)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: animal structures, Retinal Neoplasms, medicine.medical_treatment, Pharmaceutical Science, Nanoparticle, Photodynamic therapy, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Cell Line, Tumor, medicine, Humans, ComputingMilieux_MISCELLANEOUS, Drug Carriers, Retinoblastoma, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Galactose, Mesoporous silica, Silicon Dioxide, 021001 nanoscience & nanotechnology, medicine.disease, Antineoplastic Agents, Phytogenic, Molecular biology, Endocytosis, eye diseases, In vitro, 0104 chemical sciences, 3. Good health, Photochemotherapy, Cancer cell, Drug delivery, Cancer research, Nanoparticles, Camptothecin, 0210 nano-technology, Mannose, medicine.drug
Abstract: In this work, we focused on mesoporous silica nanoparticles (MSN) for one photon excitated photodynamic therapy (OPE-PDT) combined with drug delivery and carbohydrate targeting applied on retinoblastoma, a rare disease of childhood. We demonstrate that bitherapy (camptothecin delivery and photodynamic therapy) performed with MSN on retinoblastoma cancer cells was efficient in inducing cancer cell death. Alternatively MSN designed for two-photon excited photodynamic therapy (TPE-PDT) were also studied and irradiation at low fluence efficiently killed retinoblastoma cancer cells.
Published: 2012
Full Text: View/download PDF

122. A short synthesis of the unusual amino acid of cyclosporine (4R)-4-[(E)-2-butenyl]-4,N-dimethyl-L-threonine (MeBmt)

Author: Monique Savignac, Jean-Olivier Durand, and Jean-Pierre Genêt
Subjects: chemistry.chemical_classification, Sharpless epoxidation, Methylamine, Stereochemistry, Organic Chemistry, Regioselectivity, Ring (chemistry), Catalysis, Amino acid, Stereocenter, Inorganic Chemistry, chemistry.chemical_compound, Aminolysis, chemistry, Physical and Theoretical Chemistry, Aliphatic compound
Abstract: MeBmt 1 was prepared in four steps from the optically pure (2Z, 4R) 4-methyloct-6-yn-2-en-1-ol 8 , Z allylic alcohol containing an alkynyl group at the γ position. The two stereogenic centers C-2 and C-3 in the product were controlled using Sharpless' epoxidation and subsequent ring opening at C-2 of the epoxy acid 10 with methylamine.
Published: 1994
Full Text: View/download PDF

123. Phosphonate derivatives of pyridine grafted onto oxide nanoparticles

Author: Gérard F. Lanneau, Richard Frantz, Jean-Olivier Durand, and Michel Granier
Subjects: Chemistry, Organic Chemistry, Oxide, Grafting, Biochemistry, Phosphonate, Metal, chemistry.chemical_compound, Hydrolysis, visual_art, Heck reaction, Drug Discovery, Polymer chemistry, Pyridine, visual_art.visual_art_medium, Organic chemistry, Reactivity (chemistry)
Abstract: The synthesis of phosphonate derived stilbazole 1 by using a Heck reaction is described. The reactivity of the pyridine moiety is studied. After hydrolysis of the ethyl phosphonate groups, the grafting of phosphonic acid derived stilbazole 5 on metal oxides TiO2 or SnO2 is reported. The accessibility and reactivity of the pyridine moiety at the surface is demonstrated.
Published: 2002
Full Text: View/download PDF

124. Hyaluronic acid-functionalized mesoporous silica nanoparticles for efficient photodynamic therapy of cancer cells

Author: Magali Gary-Bobo, Marcel Garcia, Philippe Maillard, Nadia Benkirane-Jessel, Laurence Raehm, Jean-Olivier Durand, David Brevet, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Biomatériaux et ingénierie tissulaire, Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Central, Service de Chirurgie Orthopédique (UMR7561 CNRS), Inconnu, Conception, synthèse et vectorisation de biomolécules. (CSVB), Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), and Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]
Subjects: animal structures, medicine.medical_treatment, Biophysics, Photodynamic therapy, Apoptosis, 02 engineering and technology, Dermatology, 010402 general chemistry, Endocytosis, 01 natural sciences, chemistry.chemical_compound, Nanocapsules, Cell Line, Tumor, Hyaluronic acid, medicine, Moiety, Humans, Pharmacology (medical), Hyaluronic Acid, ComputingMilieux_MISCELLANEOUS, biology, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Chemistry, CD44, Mesoporous silica, 021001 nanoscience & nanotechnology, Silicon Dioxide, 0104 chemical sciences, Treatment Outcome, Oncology, Biochemistry, Photochemotherapy, Cell culture, Cancer cell, biology.protein, Cancer research, sense organs, 0210 nano-technology, Colorectal Neoplasms, Porosity
Abstract: Mesoporous silica nanoparticles (MSN) for photodynamic therapy (PDT) were coated with poly-(L-lysine) and hyaluronic acid (HA) by using the layer-by-layer method. HA is able to target cancer cells over-expressing the corresponding CD44 receptor. MSN functionalized with HA (MSN-HA) were more efficient than MSN without the targeting moiety when PDT was performed at low fluence (14 Jcm(-2)) and low dosage of MSN (20 μgmL(-1)) on HCT 116 colorectal cancer cells, known to over-express the CD44 receptor. Incubation of HCT-116 cancer cells with an excess of HA impaired the PDT effect with MSN-HA thus demonstrating that an active endocytosis mechanism was involved in the uptake of MSN-HA by these cells.
Published: 2011
Full Text: View/download PDF

125. Facile route to functionalized mesoporous silica nanoparticles by click chemistry

Author: Nirmalya Moitra, Xavier Cattoën, Jean-Olivier Durand, Laurence Raehm, Philippe Trens, Michel Wong Chi Man, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: chemistry.chemical_classification, Materials science, Alkyne, Nanoparticle, 02 engineering and technology, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, Mesoporous silica, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, symbols.namesake, chemistry.chemical_compound, chemistry, Materials Chemistry, symbols, Click chemistry, Organic chemistry, Surface modification, Azide, Fourier transform infrared spectroscopy, 0210 nano-technology, Raman spectroscopy
Abstract: International audience; Mesoporous silica nanoparticles containing clickable functions (azide or alkyne, 1 or 10 mol%) were synthesized by the sol-gel method directly from molecular precursors using CTAB as structure directing agent. Their structures were discussed on the basis of TEM, DLS, SAXS, N2-sorption analyses, FTIR, Raman and elemental analysis. The success of their functionalization by pyrene derivatives using CuAAC reactions opens new perspectives in the synthesis of functional MSNs for applications as nanomachines.
Published: 2011
Full Text: View/download PDF

126. Nanoparticles for photodynamic therapy applications

Author: Laurence Raehm, Muriel Barberi-Heyob, Sébastien Richeter, Céline Frochot, Jean-Olivier Durand, Régis Vanderesse, Laboratoire de Chimie Physique Macromoléculaire (LCPM), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Automatique de Nancy (CRAN), Université Henri Poincaré - Nancy 1 (UHP)-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Centre Alexis Vautrin (CAV), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: Chemistry, medicine.medical_treatment, Nanoparticle, Photodynamic therapy, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, 3. Good health, Radiation therapy, In vivo, Cancer cell, medicine, Nanomedicine, Photosensitizer, [SDV.IB]Life Sciences [q-bio]/Bioengineering, 0210 nano-technology
Abstract: ISBN 978-94-007-1247-8 http://www.springer.com/life+sciences/cell+biology/book/978-94-007-1247-8; Photodynamic therapy has emerged as an alternative to chemo- and radiotherapy for the treatment of certain types of cancer. Nanoparticles have been used to improve the delivery and the efficiency of the photosensitizer as they allow its encapsulation without loss of activity. Using targeting strategies, they can also allow the selective accumulation of the photosensitizer in the cancer tissues. In this review, based on the chemical nature of the nanoparticles, the different methods for their syntheses are described from the pioneering works to the latest achievements. Indeed the nanosystems can be conjugated to a biomolecule or an antibody to target receptors over-expressed in cancer cells and/or angiogenic vascular endothelial cells. Numerous in vivo and in vitro applications have been described. Multifunctional nanoplatforms combining several applications within the same nano-object emerge as potential important theranostic tools.
Published: 2011
Full Text: View/download PDF

127. Mannose-Functionalized Mesoporous Silica Nanoparticles for Efficient Two-Photon Photodynamic Therapy of Solid Tumors

Author: Marie Maynadier, Laurence Raehm, Ophélie Vaillant, Jean-Olivier Durand, Cédric Rouxel, Marcel Garcia, Ilaria Basile, Youssef Mir, Magali Gary-Bobo, Olivier Mongin, David Brevet, Mireille Blanchard-Desce, Alain Morère, Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Chimie et Photonique Moléculaires (CPM), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), controle de la progression des cancers hormonaux-dependants, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)
Subjects: medicine.medical_treatment, Mannose, Nanoparticle, Mice, Nude, Photodynamic therapy, Context (language use), Breast Neoplasms, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Catalysis, chemistry.chemical_compound, Mice, Drug Delivery Systems, Two-photon excitation microscopy, Cell Line, Tumor, medicine, Animals, Humans, ComputingMilieux_MISCELLANEOUS, Photosensitizing Agents, 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Cancer, General Chemistry, General Medicine, Mesoporous silica, medicine.disease, Silicon Dioxide, 021001 nanoscience & nanotechnology, Combinatorial chemistry, Xenograft Model Antitumor Assays, 0104 chemical sciences, Radiation therapy, Mannose-Binding Lectins, chemistry, Photochemotherapy, Nanoparticles, Female, 0210 nano-technology
Abstract: In the context of national systematic screenings for cancer,photodynamic therapy (PDT) has arisen as an alternative tochemo- and radiotherapy for the non-invasive selectivedestruction of small tumors. PDT involves the use of aphotosensitizer which, upon irradiation at specific wave-lengths, in the presence of oxygen, leads to the generation ofcytotoxic species and consequently to irreversible celldamage.
Published: 2011
Full Text: View/download PDF

128. New phosphonates containing a π-conjugated ferrocenyl unit

Author: Ge´rard F. Lanneau, F. Carre, Richard Frantz, and Jean-Olivier Durand
Subjects: Absorption spectroscopy, Phosphorus, Halide, chemistry.chemical_element, General Chemistry, Crystal structure, Conjugated system, Electrochemistry, Catalysis, Crystallography, chemistry, Materials Chemistry, Organic chemistry, Unit (ring theory)
Abstract: A new class of phosphorus compounds containing a ferrocenyl unit are obtained from vinylferrocene and phosphono-substituted aromatic halides by using palladium-catalyzed Heck-type reactions. The crystal structure of compound 3a confirms the trans planar geometry of the π-conjugated system. The electrochemistry and electronic absorption spectra of phosphorus esters 3a,b and acids 4a,b are investigated.
Published: 2001
Full Text: View/download PDF

129. ChemInform Abstract: Synthesis of 3-Fluoro Azetidinone by Electrophilic Fluorination

Author: Sylvain Roland, Monique Savignac, F. Jung, Jean-Pierre Genêt, and Jean-Olivier Durand
Subjects: Chemistry, Yield (chemistry), Electrophilic fluorination, Organic chemistry, General Medicine
Abstract: An easy access to the 3-fluoroazetidinone 4a based on electrophilic fluorination, is reported. The fluorination of the β-lactam 7 with Differding's N-fluorosulfonimide proceeds stereoselectively, under mild conditions and in good yield.
Published: 2010
Full Text: View/download PDF

130. ChemInform Abstract: Reductive Cyanation: A Key Step for a Short Synthesis of (-)-(2S,3S)-3-Hydroxyproline

Author: Marc Larchevêque, Yves Petit, and Jean-Olivier Durand
Subjects: Chemistry, Yield (chemistry), Stereoselectivity, General Medicine, 3-hydroxyproline, Cyanation, Chirality (chemistry), Combinatorial chemistry
Abstract: A short stereoselective synthesis of (−)-(2 S ,3 S )-3-hydroxyproline has been realized from L-malic acid as the source of chirality. The key step was the reductive cyanation of the intermediate 1a , in high stereoselectivity and yield.
Published: 2010
Full Text: View/download PDF

131. ChemInform Abstract: The Reactivity of (1R,1′R)-3-exo, 3′-exo-Bicamphor; Preparation of New 3-exo, 3′-exo-Bibornane Derivatives

Author: Jean-Olivier Durand
Subjects: chemistry.chemical_classification, chemistry, Organic chemistry, Reactivity (chemistry), General Medicine, Bridged compounds
Published: 2010
Full Text: View/download PDF

132. ChemInform Abstract: Modeling One- and Two-Dimensional Solid-State NMR Spectra

Author: Bruno Bujoli, Jean-Olivier Durand, Bruno Alonso, Dominique Massiot, Franck Fayon, Stéphanie Le Calvé, Ian King, Mickaël Capron, Gina L. Hoatson, and Zhehong Gan
Subjects: Solid-state nuclear magnetic resonance, Chemistry, Physical chemistry, General Medicine, Spectral line
Published: 2010
Full Text: View/download PDF

133. Mesoporous Silica Nanoparticles Combining Two-Photon Excited Fluorescence and Magnetic Properties

Author: Kalaivani Thangavel, Laurence Raehm, Elena Chelebaeva, Youssef Mir, Mireille Blanchard-Desce, Yannick Guari, Marc Willinger, Christian Guérin, A. A. Trifonov, Olivier Mongin, Alessandro Lascialfari, Joulia Larionova, Jean-Olivier Durand, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Russian Acad Sci, GA Razunaev Inst Organomet Chem, Russian Academy of Sciences [Moscow] (RAS), Universidade de Aveiro, Istituto di Fisiologia Generale e Chimica Biologica, Università degli Studi di Milano [Milano] (UNIMI), Synthèse et électrosynthèse organiques (SESO), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Milano = University of Milan (UNIMI), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, Coordination polymer, Analytical chemistry, Nanoparticle, 02 engineering and technology, General Chemistry, Mesoporous silica, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, Chemical engineering, chemistry, Transmission electron microscopy, Materials Chemistry, Magnetic nanoparticles, [CHIM.COOR]Chemical Sciences/Coordination chemistry, 0210 nano-technology, Luminescence, High-resolution transmission electron microscopy, ComputingMilieux_MISCELLANEOUS, Superparamagnetism
Abstract: A new approach to the synthesis of multifunctional nanoparticles was developed by using covalent anchoring of cyano-bridged coordination polymer Ni2+/[Fe(CN)6]3− to the surface of two-photon dye-doped mesoporous silica nanoparticles. The obtained hybrid nanoparticles were studied by infrared (IR) spectroscopy, nitrogen adsorption (BET), X-ray diffraction, transmission electron microscopy (TEM), high resolution transmission electron microscopy (HRTEM), luminescence, and magnetic analysis. The synthesis leads to homogeneously dispersed uni-shaped nanoparticles of around 100 nm in length that are coated with cyano-bridged metallic coordination polymer nanoparticles. These hybrid nanoparticles combine effective two-photon excited fluorescence, porosity, high transverse nuclear relaxivity values (i.e. the magnetic resonance imaging efficiency) and superparamagnetic properties.
Published: 2010
Full Text: View/download PDF

134. Silicalites and Mesoporous Silica Nanoparticles for photodynamic therapy

Author: Pierre Couleaud, Sébastien Richeter, Alain Morère, Magali Gary-Bobo, Ouahiba Hocine, Monique Smaïhi, Simon Fontanel, Bernard Loock, Marie Maynadier, Laurence Raehm, Gaelle Derrien, Philippe Maillard, Céline Frochot, Jean-Olivier Durand, Clarence Charnay, Amar Sahmoune, David Brevet, Marcel Garcia, Conception, synthèse et vectorisation de biomolécules. (CSVB), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institut Européen des membranes (IEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Marie, Nathalie, Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: medicine.medical_treatment, Pharmaceutical Science, Nanoparticle, Mannose, Photodynamic therapy, Nanotechnology, Breast Neoplasms, Receptors, Cell Surface, 02 engineering and technology, 010402 general chemistry, Endocytosis, 01 natural sciences, chemistry.chemical_compound, Drug Delivery Systems, Cell Line, Tumor, medicine, Humans, Lectins, C-Type, Microparticle, ComputingMilieux_MISCELLANEOUS, Fluorescent Dyes, Microscopy, Confocal, Singlet Oxygen, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Silicates, [CHIM.MATE]Chemical Sciences/Material chemistry, Mesoporous silica, 021001 nanoscience & nanotechnology, Silicon Dioxide, [CHIM.ORGA] Chemical Sciences/Organic chemistry, 3. Good health, 0104 chemical sciences, Mannose-Binding Lectins, Photochemotherapy, Biophysics, Surface modification, Nanoparticles, Female, Fluorescein, 0210 nano-technology, Mesoporous material, Lysosomes, Mannose Receptor
Abstract: International audience; The synthesis of silicalites and Mesoporous Silica Nanoparticles (MSN), which covalently incorporate original water-soluble photosensitizers for PDT applications is described. PDT was performed on MDA-MB-231 breast cancer cells. All the nanoparticles showed significant cell death after irradiation, which was not correlated with 1O2 quantum yield of the nanoparticles. Other parameters are involved and in particular the surface and shape of the nanoparticles which influence the pathway of endocytosis. Functionalization with mannose was necessary to obtain the best results with PDT due to an active endocytosis of mannose-functionalized nanoparticles. The quantity of mannose on the surface should be carefully adjusted as a too high amount of mannose impairs the phototoxicity of the nanoparticles. Fluorescein was also encapsulated in MCM-41 type MSN in order to localize the nanoparticles in the organelles of the cells by confocal microscopy. The MSN were localized in lysosomes after active endocytosis by mannose receptors.
Published: 2010
Full Text: View/download PDF

135. Folic Acid-Targeted Mesoporous Silica Nanoparticles for Two-Photon Fluorescence

Author: Martinus H. V. Werts, Delphine Méthy-Gonnod, Laurence Raehm, Jean-Olivier Durand, Monique Smaïhi, Catherine Dubernet, Mireille Blanchard-Desce, Valérie Lebret, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut Européen des membranes (IEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM), Chimie et Photonique Moléculaires (CPM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Synthèse et électrosynthèse organiques (SESO), Physico-chimie, pharmacotechnie, biopharmacie (PCPB), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, Cell Survival, medicine.medical_treatment, Biomedical Engineering, Pharmaceutical Science, Medicine (miscellaneous), Nanoparticle, Bioengineering, Photodynamic therapy, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Polyethylene Glycols, HeLa, Drug Delivery Systems, Folic Acid, Cell Line, Tumor, PEG ratio, medicine, Organic chemistry, Humans, General Materials Science, Cytotoxicity, ComputingMilieux_MISCELLANEOUS, biology, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Mesoporous silica, 021001 nanoscience & nanotechnology, biology.organism_classification, Silicon Dioxide, 3. Good health, 0104 chemical sciences, Spectrometry, Fluorescence, Cell culture, Cancer cell, Nanoparticles, 0210 nano-technology, Nuclear chemistry
Abstract: New nanotools for the imaging of cancer cells have been synthesized. Two-photon dye-doped 3-aminopropyltriethoxysilane-grafted mesoporous silica nanoparticles (MSN) have been grafted with folic acid (FA) functionalized PEG groups. Amine-PEG groups were first reacted with an activated ester derivative of FA. A mixture of FA- and hydroxyl-PEG has then been reacted with the amino groups at the surface of the particles. Cell culture experiments performed with MCF7 and HeLa cancer cells demonstrated that these functionalized MSN showed a low cytotoxicity even after a 24 hours incubation time at high concentrations. These modified MSN are promising for applications in the field of two-photon imaging and their potentiality for photodynamic therapy is currently being investigated.
Published: 2010
Full Text: View/download PDF

136. Silica-based nanoparticles for photodynamic therapy applications

Author: Laurence Raehm, Vincent Morosini, Jean-Olivier Durand, Céline Frochot, Pierre Couleaud, Sébastien Richeter, Centre de Recherche en Automatique de Nancy (CRAN), Université Henri Poincaré - Nancy 1 (UHP)-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)
Subjects: Materials science, Photosensitizing Agents, [CHIM.ORGA]Chemical Sciences/Organic chemistry, medicine.medical_treatment, Nanoparticle, Nanotechnology, Photodynamic therapy, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Silicon Dioxide, 01 natural sciences, 3. Good health, 0104 chemical sciences, Photochemotherapy, Silica matrix, Neoplasms, medicine, Humans, Nanoparticles, General Materials Science, Photosensitizer, 0210 nano-technology, Reactive Oxygen Species
Abstract: International audience; Silica-based nanoparticles for applications in photodynamic therapy (PDT) have emerged as a promising field for the treatment of cancer. In this review, based on the pathway the photosensitizer is entrapped inside the silica matrix, the different methods for the synthesis of silica-based nanoparticles are described from the pioneering works to the latest achievements which concern multifunctional nanoplatforms, up-converting nanoparticles, two-photon PDT, vectorization and in vivo applications.
Published: 2010
Full Text: View/download PDF

137. Attachment of trianglamines to silicon wafers, chiral recognition by chemical force microscopy

Author: Jana Hodačová, Laurence Raehm, Michel Ramonda, Jean-Olivier Durand, Jiri Hlinka, Michel Granier, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB / CAS), Czech Academy of Sciences [Prague] (CAS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Laboratoire de Microscopie en Champ Proche (LMCP), and Université Montpellier 2 - Sciences et Techniques (UM2)
Subjects: Silicon, 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, General Chemical Engineering, chemistry.chemical_element, Nanotechnology, General Chemistry, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Contact angle, chemistry, Chemical force microscopy, Ellipsometry, Monolayer, Surface modification, Wafer, Self-assembly, ComputingMilieux_MISCELLANEOUS
Abstract: The chemical attachment of enantiomerically pure trianglamines to silicon wafers through isocyanate functions was performed. The self-assembled monolayer was analyzed by ATR-FTIR, ellipsometry, AFM, contact angle measurements. An AFM tip was functionalized by enantiomerically pure trianglamine using the same pathway. Chemical force microscopy showed chiral recognition between the functionalized tip and the functionalized wafer.
Published: 2010
Full Text: View/download PDF

138. Asymmetric synthesis of MeBma analog of C9 amino acid present in cyclosporine

Author: Jean Olivier Durand, Jean Pierre Genêt, Monique Savignac, and Dominique Pons
Subjects: inorganic chemicals, chemistry.chemical_classification, Sharpless epoxidation, Methylamine, Stereochemistry, organic chemicals, Organic Chemistry, Absolute configuration, Enantioselective synthesis, Biochemistry, Aldehyde, Amino acid, chemistry.chemical_compound, chemistry, Yield (chemistry), Drug Discovery, health occupations, polycyclic compounds, heterocyclic compounds, Aliphatic compound
Abstract: MeBma 2, C9 analog of MeBmt amino acid present in cyclosporine (immunosuppressive drug) is readily available in 5 steps (23% overall yield) from chiral aldehyde 7 by inermolecular opening at C-2 of chiral epoxy acid 10 with methylamine. The absolute configuration was initially introduced by means of Sharpless epoxidation of E chiral allylic alcohol 8.
Published: 1992
Full Text: View/download PDF

139. Copper in In2S3: a study by x-ray diffraction, diffuse reflectance and x-ray absorption

Author: F. Py, Jean-Olivier Durand, R.C. Karnatak, Manfred Womes, Josette Olivier-Fourcade, Jean-Claude Jumas, and J.-M. Esteva
Subjects: Mechanical Engineering, Spinel, Inorganic chemistry, Metals and Alloys, chemistry.chemical_element, engineering.material, Copper, Redox, chemistry, Mechanics of Materials, X-ray crystallography, Materials Chemistry, engineering, Diffuse reflection, Absorption (chemistry), Indium, Solid solution
Abstract: A study of the In2S3Cu2SCuS system has shown the existence of a solid solution range with the In2S3 vacant spinel crystal structure. An X-ray diffraction study has allowed the identification of two redox processes in the formation of solid solutions with CuS, which is a mixed valency copper sulphide, Cu21Cu11(S2)2−S−. At low CuS concentrations all copper(I) is oxidized to copper(II) and the substitution of indium(III) by copper(II) proceeds without sulphur loss. At higher CuS concentrations the redox reaction is restricted to the sulphur atoms and the substitution of indium(III) by copper(I) and copper(II) is accompanied by sulphur losses. The presence of copper in two oxidation states has been confirmed by diffuse reflectance and X-ray absorption at the Cu K edge.
Published: 1992
Full Text: View/download PDF

140. [Mesoporous silica nanoparticles for two-photon fluorescence]

Author: Valérie, Lebret, Laurence, Raehm, Jean-Olivier, Durand, Monique, Smaïhi, Corine, Gerardin, Nicolas, Nerambourg, Martinus H V, Werts, Mireille, Blanchard-Desce, Delphine, Méthy-Gonnod, and Catherine, Dubernet
Subjects: Optics and Photonics, Microscopy, Fluorescence, Multiphoton, Surface Properties, Nanoparticles, Nanotechnology, Silicon Dioxide
Abstract: Mesoporous silica nanoparticles have unique properties: a specific large surface or a narrow casting of the sizes of pores. The perspectives of use are the creation of new tools for the premature diagnosis. For these potential biological applications, the harmlessness of these nanoparticles must be established.
Published: 2009

141. Nanoparticules mésoporeuses de silice (MSN) et applications biologiques

Author: Jean-Olivier Durand and Laurence Raehm
Abstract: Des nanoparticules mesoporeuses de silice (MSN), c'est-a-dire des particules d'un diametre de l'ordre de 60 a 300 nm, possedant une porosite organisee en reseau hexagonal avec des diametres de pores de 1,5 a 10 nm et de grandes surfaces specifiques de l'ordre de 1000 m2.g-1, ont pu etre synthetisees. Elles possedent des proprietes uniques, notamment une grande surface specifique et une distribution etroite de taille de pores. Elles peuvent etre facilement fonctionnalisees et sont biocompatibles, ce qui en font des candidates ideales pour des applications biologiques. Ainsi, des MSN ont ete utilisees pour le marquage cellulaire, en encapsulant dans leurs pores des fluorophores mono ou biphotoniques. Elles trouvent egalement des utilisations en transfection genetique ou comme agents de contraste en IRM. Enfin, les systemes de delivrance controlee de medicaments en sont une des applications les plus prometteuses pour l'amelioration de la sante humaine.
Published: 2009
Full Text: View/download PDF

142. ChemInform Abstract: Semicarbazide/α-Oxoaldehyde Site-Specific Ligation Chemistry -From Peptide Microarrays to the Micropatterning of Polycarbonate or Titanium Oxide Using Silica Nanoparticles

Author: Ouafaa El-Mahdi, Vianney Souplet, Olivier Carion, Clement Roux, Jean-Michel Garcia, Celine Maillet, Christophe Olivier, Oleg Melnyk, and Jean-Olivier Durand
Subjects: General Medicine
Published: 2009
Full Text: View/download PDF

143. Towards thrombosis-targeted zeolite nanoparticles for laser-polarized 129Xe MRI

Author: Julien Detour, Oleg Melnyk, Frédéric Lerouge, Hervé Desvaux, André Constantinesco, Jean-Olivier Durand, Monique Smaïhi, Laurence Raehm, Philippe Choquet, Patrick Berthault, Gaspard Huber, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Européen des membranes (IEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM), Service de Biophysique et Médecine Nucléaire, CHU Strasbourg-Université Louis Pasteur - Strasbourg I-Hôpital de Hautepierre [Strasbourg], Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: chemistry.chemical_classification, Semicarbazide, Biodistribution, Materials science, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Nanoparticle, Peptide, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, In vivo, PEG ratio, Materials Chemistry, Surface modification, Organic chemistry, 0210 nano-technology, Zeolite, ComputingMilieux_MISCELLANEOUS
Abstract: The synthesis and functionalisation of zeolite nanoparticles designed for laser-polarized 129Xe NMR experiments in solution are described. These nanoparticles were functionalized by using original synthesis pathways through semicarbazide COCHO chemistry in order to ensure anchoring of a peptide for targeting biological receptors and attachment of PEG chains for in vivo experiments. Results demonstrated that accessibility of the dissolved noble gas to the micropores was maintained after functionalization. γ Scintigraphy with 111In linked to the zeolite particles has been investigated in order to follow the behaviour of the zeolite nanoparticles in mice. These preliminary 111In scintigraphy experiments showed the localization of the nanoparticles after injection in mice and their biodistribution, as a first proof-of-concept towards in vivo129Xe MRI.
Published: 2009
Full Text: View/download PDF

144. Mannose-targeted mesoporous silica nanoparticles for photodynamic therapy

Author: Laurence Raehm, Jean-Olivier Durand, David Brevet, Alain Morère, Kassem Amro, Pierre Couleaud, Sébastien Richeter, Céline Frochot, Magali Gary-Bobo, Philippe Maillard, Marcel Garcia, Bernard Loock, Ouahiba Hocine, Le Ster, Yves, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Conception, synthèse et vectorisation de biomolécules. (CSVB), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Département de Chimie Physique des Réactions (DCPR), Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Financial support by ANR PNANO. 07-102, Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), and Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)
Subjects: [SDV.BIO]Life Sciences [q-bio]/Biotechnology, medicine.medical_treatment, Nanoparticle, Mannose, Apoptosis, Photodynamic therapy, 02 engineering and technology, 01 natural sciences, chemistry.chemical_compound, Drug Delivery Systems, Materials Chemistry, polycyclic compounds, [INFO.INFO-BT]Computer Science [cs]/Biotechnology, Receptor, ComputingMilieux_MISCELLANEOUS, MESH: Receptors, Cell Surface, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Molecular Structure, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Metals and Alloys, Silicon Dioxide, 021001 nanoscience & nanotechnology, 3. Good health, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, MESH: Mannose, 0210 nano-technology, therapeutics, Mannose Receptor, animal structures, MESH: Cell Line, Tumor, education, MESH: Drug Delivery Systems, MESH: Molecular Structure, Receptors, Cell Surface, [SDV.CAN]Life Sciences [q-bio]/Cancer, 010402 general chemistry, Catalysis, MESH: Silicon Dioxide, [SDV.CAN] Life Sciences [q-bio]/Cancer, Cell Line, Tumor, MESH: Mannose-Binding Lectins, medicine, Humans, Lectins, C-Type, MESH: Photochemotherapy, MESH: Humans, MESH: Apoptosis, General Chemistry, Mesoporous silica, eye diseases, 0104 chemical sciences, [SDV.BIO] Life Sciences [q-bio]/Biotechnology, Mannose-Binding Lectins, [INFO.INFO-BT] Computer Science [cs]/Biotechnology, Photochemotherapy, chemistry, Cell culture, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: HeLa Cells, Ceramics and Composites, Cancer research, Nanoparticles, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, sense organs, Breast cancer cells, MESH: Lectins, C-Type, MESH: Nanoparticles, HeLa Cells
Abstract: International audience; Functionalisation of MSN with mannose for PDT applications dramatically improved the efficiency of PDT on breast cancer cells.
Published: 2009
Full Text: View/download PDF

145. Surface functionalization of two-photon dye-doped mesoporous silica nanoparticles with folic acid: cytotoxicity studies with HeLa and MCF-7 cancer cells

Author: Laurence Raehm, Martinus H. V. Werts, Mireille Blanchard-Desce, Valérie Lebret, Delphine Méthy-Gonnod, Jean-Olivier Durand, Monique Smaïhi, Catherine Dubernet, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Synthèse et électrosynthèse organiques (SESO), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Chimie et Photonique Moléculaires (CPM), Physico-chimie, pharmacotechnie, biopharmacie (PCPB), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)
Subjects: inorganic chemicals, Materials science, Fluorophore, education, Nanoparticle, 02 engineering and technology, Conjugated system, 010402 general chemistry, 01 natural sciences, Biomaterials, HeLa, chemistry.chemical_compound, Materials Chemistry, Organic chemistry, health care economics and organizations, ComputingMilieux_MISCELLANEOUS, Quenching (fluorescence), biology, [CHIM.ORGA]Chemical Sciences/Organic chemistry, technology, industry, and agriculture, General Chemistry, respiratory system, Mesoporous silica, 021001 nanoscience & nanotechnology, Condensed Matter Physics, biology.organism_classification, Fluorescence, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, chemistry, Ceramics and Composites, Surface modification, 0210 nano-technology, Nuclear chemistry
Abstract: Two-photon dye-doped mesoporous silica nanoparticles (NPs) have been conjugated with folic acid (FA) in order to obtain efficient nanotools for bioimaging of cancer cells. The surface of the NPs was first functionalized with 3-aminopropyltriethoxysilane. The amine-covered NPs were subsequently reacted with an activated ester derivative of FA. Cytotoxicity studies performed with MCF7 and HeLa cancer cells demonstrate that these functionalized NPs are much less cytotoxic than the non-functionalized NPs against both cell lines. Unfortunately, the grafting of FA enables the formation of charge transfer complexes between the two-photon dye and FA which leads to quenching of the fluorescence of the NPs. Hence although these NPs cannot be used for biomaging purposes, they offer interesting potentialities if the two-photon dye used can be replaced by a two-photon fluorophore which do not interact with FA or if the interaction between the encapsulated dye and FA can be prevented by using a suitable spacer between the surface and the FA moiety.
Published: 2008
Full Text: View/download PDF

146. Semicarbazide/α-Oxo Aldehyde Site-Specific Ligation Chemistry: From Peptide Microarrays to the Micropatterning of Polycarbonate or Titanium Oxide Using Silica Nanoparticles

Author: Oleg Melnyk, Clément Roux, Céline Maillet, Ouafâa El‐Mahdi, Vianney Souplet, Jean-Michel Garcia, Christophe Olivier, Olivier Carion, and Jean-Olivier Durand
Subjects: chemistry.chemical_classification, Semicarbazide, Peptide, Aldehyde, Combinatorial chemistry, Titanium oxide, Silica nanoparticles, chemistry.chemical_compound, chemistry, visual_art, visual_art.visual_art_medium, Organic chemistry, Polycarbonate, Ligation, Micropatterning
Published: 2008
Full Text: View/download PDF

147. Synthesis and Characterization of Fluorescently Doped Mesoporous Nanoparticles for Two-Photon Excitation

Author: Valérie Lebret, Mireille Blanchard-Desce, Laurence Raehm, Corine Gérardin, Nicolas Nerambourg, Martinus H. V. Werts, Jean-Olivier Durand, Monique Smaïhi, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Européen des membranes (IEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM), Barbedor, Catherine, Chimie et Photonique Moléculaires (CPM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, [CHIM.ORGA]Chemical Sciences/Organic chemistry, General Chemical Engineering, Nanoparticle, 02 engineering and technology, General Chemistry, Conjugated system, Mesoporous silica, 010402 general chemistry, 021001 nanoscience & nanotechnology, Photochemistry, 01 natural sciences, Fluorescence, Acceptor, 0104 chemical sciences, Two-photon excitation microscopy, Heck reaction, Materials Chemistry, Organic chemistry, 0210 nano-technology, Mesoporous material, [CHIM.OTHE]Chemical Sciences/Other, ComputingMilieux_MISCELLANEOUS
Abstract: The template-directed synthesis of mesoporous silica nanoparticles doped with water-soluble fluorescent dyes optimized for two-photon excitation is described. Two structurally related symmetrical two-photon dyes that possess pyridinium acceptor endgroups conjugated to a fluorenyl core are synthesized by Heck coupling. These dyes display bright fluorescence (Φ ≈ 0.35) under both one- (ϵ ≈ 6 × 104 M−1 cm−1) and two-photon excitation (σ2 ≈ 1000 GM) and were successfully encapsulated in silica nanoparticles via immobilization through noncovalent interactions. The nanoparticles present a mean diameter of 100 nm and a hexagonal network of mesopores as shown by TEM. Interestingly, the photophysical characteristics of the dyes are retained upon their immobilization into the silica matrix, leading to fluorescent silica nanoparticles with giant/unprecedented TPA cross-section (1 × 107 GM). Such nanospheres represent attractive nanoplatforms for the development of biotargeted biocompatible luminescent tracers.
Published: 2008
Full Text: View/download PDF

148. Covalent functionalization of silicon nitride surfaces by semicarbazide group

Author: J. P. Nys, Yannick Coffinier, Rabah Boukherroub, Bruno Grandidier, Didier Stiévenard, Xavier Wallart, Jean-Olivier Durand, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), and Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Semicarbazide, Materials science, 02 engineering and technology, Surfaces and Interfaces, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Photochemistry, 01 natural sciences, 0104 chemical sciences, Surfaces, Coatings and Films, Contact angle, chemistry.chemical_compound, X-ray photoelectron spectroscopy, chemistry, Silicon nitride, Covalent bond, Monolayer, Materials Chemistry, Thin film, 0210 nano-technology, Protecting group
Abstract: The paper reports on the covalent attachment of semicarbazide functional groups onto hydrogen-terminated silicon-rich silicon nitride (SixN4; 4
Published: 2007
Full Text: View/download PDF

149. Porphyrin-Functionalized Porous Silicon Nanoparticles for Photodynamic Therapy

Author: Emilie Secret, Marie Maynadier, Audrey Gallud, Arnaud Chaix, Elise Bouffard, Magali Gary-Bobo, Nathalie Marcotte, Olivier Mongin, Khaled El Cheikh, Vincent Hugues, Melanie Auffan, Céline Frochot, Alain Morère, Philippe Maillard, Mireille Blanchard-Desce, M. J. Sailor, Marcel Garcia, Jean-Olivier Durand, and Frederique Cunin
Abstract: Nanomaterials offer the potential for minimally invasive and focal therapies to reduce side-effects associated with systemic administration of anticancer drugs. Clinical treatment involving photodynamic therapy is particularly attractive since it allows spatial and temporal control of the production of highly cytotoxic singlet oxygen and reactive oxygen species through local excitation of a photosensitizer. Porous silicon nanoparticles (pSiNP), obtained by electrochemical etching of crystalline silicon followed by ultrasonic treatment, are particularly attractive for nanomedicine because they are bioresorbable in vivo and their degradation product, silicic acid, is non-toxic. In addition pSiNP display intrinsic optical properties (luminescence) deriving from their semi-conductive nature, very usefull for imaging. Here we will present simple photosensitizer/pSiNP systems based on a porphyrin derivative covalently attached to the nanoparticle, and demonstrate imaging and PDT in vitro under one (OPE) and two photon excitation (TPE) conditions. We will describe the preparation of the biodegradable pSiNP, the chemical functionalization of pSiNP with the photosensitizer by the covalent anchoring of a porphyrin into the porous silicon matrix using a new type of conjugation chemistry, as well as their functionalization with cancer cell targeting species. The targeting and photodynamic efficiency of the described formulations on various cancer cell lines will be presented. We will show that both types of excitation, OPE and TPE, lead to cell death through different excitation pathways. Emilie Secret, Marie Maynadier, Audrey Gallud, Arnaud Chaix, Elise Bouffard, Magali Gary-Bobo, Nathalie Marcotte, Olivier Mongin, Khaled El Cheikh, Vincent Hugues, Mélanie Auffan, Céline Frochot, Alain Morère, Philippe Maillard, Mireille Blanchard-Desce, Michael J. Sailor, Marcel Garcia, Jean-Olivier Durand and Frédérique Cunin,Two-Photon Excitation of Porphyrin Functionalized Porous Silicon Nanoparticles for Photodynamic Therapy Adv. Mater., 2014, Online. DOI: 10.1002/adma.201403415. Emilie Secret, Marie Maynadier, Audrey Gallud, Magali Gary-Bobo, Arnaud Chaix, Emmanuel Belamie, Philippe Maillard, Michael J. Sailor, Marcel Garcia, Jean-Olivier Durand, Frédérique Cunin, Anionic porphyrin-grafted porous silicon nanoparticles for photodynamic therapy,Chem. Commun., 2013, 49(39), 4202-4204. DOI: 10.1039/C3CC38837A
Published: 2015
Full Text: View/download PDF

150. Semicarbazide-Functionalized Silicate Nanoparticles for Peptide Ligation

Author: Christophe Olivier, Oleg Melnyk, Ouafâa El-Mahdi, Jean-Olivier Durand, Monique Smaïhi, Céline Maillet, Tristan Doussineau, Institut Européen des membranes (IEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM), Institut de Biologie, Centre National de la Recherche Scientifique (CNRS), Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN), Recherches en cancérologie, and Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: chemistry.chemical_classification, Semicarbazide, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Dispersity, Inorganic chemistry, Nanoparticle, Peptide, 02 engineering and technology, Microporous material, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Silicate, 0104 chemical sciences, Inorganic Chemistry, Rhodamine, chemistry.chemical_compound, chemistry, Chemical engineering, 0210 nano-technology, Zeolite, ComputingMilieux_MISCELLANEOUS
Abstract: Monodisperse silicate nanoparticles have been used for the development of a site-specific ligation method that enables the control of the biomolecule orientation at the solid–liquid interface. Two types of zeolite nanoparticles were studied: zeolite β, which possesses a Si/Al ratio of 25, and silicalite-1, which is a fully silicic material. Zeolite-type materials are microporous silicate with pores of a well-defined size ranging from 2 to 20 A. Semicarbazide-functionalized silicate colloids have been prepared for the site-specific ligation of COCHO-modified polypeptides. The obtained colloidal suspensions have been characterized by complementary techniques providing information on the size distribution, morphology, and porosity of the particles and chemical nature of the grafting. The specificity of the particles’ surface for the semicarbazide group has been studied by fluorescence spectroscopy with two peptides labeled with rhodamine. A first peptide bares a COCHO functionality, which should bind covalently with the semicarbazide surface. The second peptide bares an amine end-group, which should interact by nonspecific adsorption with the surface. The results demonstrated that the peptide/colloids’ reactivity is dramatically influenced by the chemical composition of the particles’ surface. Indeed, while zeolite β (aluminosilicate) particles react indifferently with the two peptides, silicalite particles (pure silicate) anchor exclusively the peptide bearing the COCHO functionality. This particular physisorption phenomenon of zeolite β is attributed to the aluminum atoms present at the particles’ surface, which have a specific affinity for peptides. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Published: 2006
Full Text: View/download PDF

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Database

Publisher

181 results on '"Jean-Olivier Durand"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources