101. Influence of atropine on carbachol dual effect on Ca2+ mobilization in SH-SY5Y neuroblastoma cells.
- Author
-
Oras A, Järv J, and Akerman KE
- Subjects
- Dose-Response Relationship, Drug, Humans, Kinetics, Tumor Cells, Cultured, Atropine pharmacology, Calcium metabolism, Carbachol pharmacology, Cholinergic Agents pharmacology, Neuroblastoma metabolism
- Abstract
The muscarinic receptor stimulated mobilisation of calcium ions in SH-SY5Y neuroblastoma cells was measured as a function on carbachol and atropine concentrations. The combined application of this pair of muscarinic agonist and antagonist yielded a set of bell-shaped dose-response curves. In the presence of atropine the cell responses were smaller and the up-going phase of these relationships was shifted towards higher agonist concentration, while the down-going phase of these curves was not influenced by the antagonist. These results pointed to a similar mechanism of the receptor inhibition at high carbachol (agonist) concentrations and by atropine (antagonist).
- Published
- 1999
- Full Text
- View/download PDF