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1,593 results on '"Ito Masaki"'

106. Standardization of the Definition and Surgical Management of Splenic Flexure Carcinoma by an International Expert Consensus Using the Delphi Technique: Room for Improvement?

Author

Benlice, Cigdem, Parvaiz, Amjad, Baca, Bilgi, Hohenberger, Werner, Miskovic, Danilo, Stocchi, Luca, Steele, Scott, Kim, Seon-Hahn, Holm, Torbjörn, Spinelli, Antonino, Gogenur, Ismail, Panis, Yves, Hasegawa, Hirotoshi, Karachun, Alexey, Uriburu, Juan C. Patron, Ito, Masaki, Croner, Roland, Kessler, Hermann, and Kuzu, Mehmet Ayhan

Published
2023
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114. Emergence of Highly Enantioselective Catalytic Activity in a Helical Polymer Mediated by Deracemization of Racemic Pendants

Author

Ikai, Tomoyuki, Ando, Mitsuka, Ito, Masaki, Ishidate, Ryoma, Suzuki, Nozomu, Maeda, Katsuhiro, Yashima, Eiji, Ikai, Tomoyuki, Ando, Mitsuka, Ito, Masaki, Ishidate, Ryoma, Suzuki, Nozomu, Maeda, Katsuhiro, and Yashima, Eiji

Abstract

Any polymers composed of racemic repeating units are obviously optically inactive and hence chiral functions, such as asymmetric catalysis, will not be expected at all. Contrary to such a preconceived notion, we report an unprecedented helical polymer-based highly enantioselective organocatalyst prepared by polymerization of a racemic monomer with no catalytic activity. Both the right- and left-handed helical poly(biarylylacetylene)s (PBAs) composed of dynamically racemic 2-arylpyridyl-N-oxide monomer units with N-oxide moieties located in the vicinity of the helical polymer backbone can be produced by noncovalent interaction with a chiral alcohol through deracemization of the biaryl pendants. The macromolecular helicity and the axial chirality induced in the PBAs are retained (“memorized”) after complete removal of the chiral alcohol. Accordingly, the helical PBAs with dual static memory of the helicity and axial chirality show remarkable enantioselectivity (86% ee) for the asymmetric allylation of benzaldehyde. The enantioselectivity is slightly lower than that (96% ee) of the homochiral PBAs prepared from the corresponding enantiopure (R)- and (S)-monomers, but is comparable to that (88% ee) of the helical PBA composed of nonracemic monomers of ca. 60% ee.

Published
2022

115. Outcomes of Combined Revascularization Surgery for Moyamoya Disease without Preoperative Cerebral Angiography

Author

Okuyama, Tomohiro, 1000050399870, Kawabori, Masahito, Ito, Masaki, Sugiyama, Taku, Kazumata, Ken, 1000000361098, Fujimura, Miki, Okuyama, Tomohiro, 1000050399870, Kawabori, Masahito, Ito, Masaki, Sugiyama, Taku, Kazumata, Ken, 1000000361098, and Fujimura, Miki

Abstract

OBJECTIVE: Cerebral angiography is the gold standard for diagnosing moyamoya disease (MMD), whereas mag-netic resonance (MR) imaging/angiography is becoming more popular in the field of cerebrovascular disease due to its low invasiveness. Although there are concerns about using only MR imaging/angiography for preoperative analysis of MMD, considering the underestimation of pre-existing transdural collateral circulations and dangerous collaterals related to the risk of hemorrhage, we retro-spectively reviewed our 10-year experience of MR imagingefirst diagnosis and analyzed the perioperative outcomes.METHODS: We analyzed 160 consecutive direct/indirect combined revascularization procedures for MMD preoper-atively assessed using MR imaging/angiography alone. Perioperative complications were assessed for up to 2 weeks after surgery. Locations of the lesions responsible for complications were further classified into the surgical field, the ipsilateral hemisphere outside the surgical field, and the contralateral hemisphere.RESULTS: Sixty-four revascularization procedures were performed in 38 children, and 96 procedures were per-formed in 68 adults. There was no difference in the inci-dence of perioperative ischemic complications between adults (6.3%) and pediatric patients (4.7%), but hemorrhagic complications were more frequently observed in adults (7.3%) than in children (0%) (P < 0.05). There was no spe-cific lesion deviation for ischemic complications; however, hemorrhagic complications predominantly occurred in the surgical field. CONCLUSIONS: Direct/indirect combined revasculari-zation surgery based on our preoperative diagnostic pro-tocol with the MR-first strategy resulted in favorable outcomes in pediatric MMD patients with relatively low complication rates. However, the validity of the MR-first diagnostic protocol should be further evaluated in adult patients with MMD.

Published
2022

118. Impact of RNF213 c.14576G>A Variant on the Development of Direct and Indirect Revascularization in Pediatric Moyamoya Disease.

Author

Kawabori, Masahito, Ito, Masaki, Kazumata, Ken, Tokairin, Kikutaro, Hatanaka, Kanako C., Ishikawa, Susumu, Houkin, Kiyohiro, and Fujimura, Miki

Subjects
*MOYAMOYA disease, *MAGNETIC resonance angiography, *CHILD patients, *TEMPORAL arteries, *BASILAR artery
Abstract

Background: Superficial temporal artery (direct) and encephalomyosynangiosis (indirect) revascularization may develop after combined bypass surgery in pediatric patients with moyamoya disease (MMD). However, arterial development varies widely among patients, and the underlying mechanisms remain unknown. Objectives: We evaluated the relationship between the development of donor arteries after bypass surgery in pediatric patients with MMD and the MMD-susceptibility gene variant c.14576G>A of ring finger protein (RNF) 213. Methods: The data of pediatric patients with MMD (age <16 years at the time of surgery) treated with combined bypass surgery between September 2013 and April 2019 were consecutively analyzed. Quantitative measurements of the superficial temporal artery (STA), deep temporal artery (DTA), and middle meningeal artery (MMA) diameters with magnetic resonance angiography (MRA) source imaging were performed preoperatively and at 6–12 months postoperatively. The postoperative caliber change ratios (CCRs) were calculated. The relationship between CCRs and RNF213 c.14576G>A status was examined. Results: Forty-eight hemispheres from 28 pediatric patients with MMD were examined. Three hemispheres belonged to patients with the AA genotype; 33 to patients with the AG genotype (AA/AG group); and 12 to patients with the GG genotype (GG group; wild type). The CCRs for the DTA were significantly higher in patients with RNF213 variant (AA/AG group; 2.5 ± 0.1) than in the GG group (2.0 ± 0.2) (p = 0.03), whereas the CCRs for the STA were significantly higher in the GG (1.6 ± 0.1) than in the AA/AG group (1.3 ± 0.6) (p = 0.02). There was no significant difference in the CCRs for the MMA and basilar artery between the groups. Other factors, including sex, age, and MRA grading, were not associated with the development of specific bypass development. Conclusions: The extent of collateral development associated with direct or indirect bypass was found to differ between the genotypes of the RNF213 c.14576G>A associated with pediatric MMD. This genetic variant correlates with the development of the disease and affects revascularization after bypass surgery in pediatric patients with MMD. [ABSTRACT FROM AUTHOR]

Published
2023
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125. Discontinuation of tyrosine kinase inhibitors in pediatric chronic myeloid leukemia

Author

Shima, Haruko, primary, Kada, Akiko, additional, Tanizawa, Akihiko, additional, Sato, Iori, additional, Tono, Chikako, additional, Ito, Masaki, additional, Yuza, Yuki, additional, Watanabe, Akihiro, additional, Kamibeppu, Kiyoko, additional, Uryu, Hideko, additional, Koh, Katsuyoshi, additional, Imai, Chihaya, additional, Yoshida, Nao, additional, Koga, Yuhki, additional, Fujita, Naoto, additional, Saito, Akiko M., additional, Adachi, Souichi, additional, Ishii, Eiichi, additional, and Shimada, Hiroyuki, additional

Published
2022
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142. Outcome of 125 Children with Chronic Myelogenous Leukemia Who Received Transplants from Unrelated Donors: The Japan Marrow Donor Program

Author

Muramatsu, Hideki, Kojima, Seiji, Yoshimi, Ayami, Atsuta, Yoshiko, Kato, Koji, Nagatoshi, Yoshihisa, Inoue, Masami, Koike, Kazutoshi, Kawase, Takakazu, Ito, Masaki, Kurosawa, Hidemitsu, Tanizawa, Akihiko, Tono, Chikako, Hamamoto, Kazuko, Hotta, Noriko, Watanabe, Akihiro, Morishima, Yasuo, Kawa, Keisei, and Shimada, Hiroyuki

Published
2010
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147. A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis

Author

Nomoto, Yuji, primary, Takatsuka, Hirotomo, additional, Yamada, Kesuke, additional, Suzuki, Toshiya, additional, Suzuki, Takamasa, additional, Huang, Ying, additional, Latrasse, David, additional, An, Jing, additional, Gombos, Magdolna, additional, Breuer, Christian, additional, Ishida, Takashi, additional, Maeo, Kenichiro, additional, Imamura, Miyu, additional, Yamashino, Takafumi, additional, Sugimoto, Keiko, additional, Magyar, Zoltan, additional, Bogre, Laszlo, additional, Raynaud, Cecile, additional, Benhamed, Moussa, additional, and Ito, Masaki, additional

Published
2021
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150. The DREAM complex represses growth in response to DNA damage in Arabidopsis

Author

Lang, Lucas, primary, Pettkó-Szandtner, Aladár, additional, Tunçay Elbaşı, Hasibe, additional, Takatsuka, Hirotomo, additional, Nomoto, Yuji, additional, Zaki, Ahmad, additional, Dorokhov, Stefan, additional, De Jaeger, Geert, additional, Eeckhout, Dominique, additional, Ito, Masaki, additional, Magyar, Zoltán, additional, Bögre, László, additional, Heese, Maren, additional, and Schnittger, Arp, additional

Published
2021
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