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106. Mobile Phone and Wearable Sensor-Based mHealth Approach for Psychiatric Disorders and Symptoms : Systematic Review and Link to the m-RESIST Project

Author

M-RESIST Grp, Seppala, Jussi, De Vita, Ilaria, Miettunen, Jouko, Isohanni, Matti, Rubinstein, Katya, Feldman, Yoram, Grasa, Eva, Corripio, Iluminada, Berdun, Jesus, D'Amico, Enrico, Bulgheroni, Maria, and HYKS erva

Subjects
mobile phone, SERIOUS MENTAL-ILLNESS, ecological momentary assessment, RECOGNITION, INPATIENTS, sensors, DEPRESSION, 3124 Neurology and psychiatry, psychiatric disorder, schizophrenia, EMA, SOCIAL RHYTHMS, TECHNOLOGIES, m-RESIST, HEALTH, SMARTPHONES, INTERVENTION
Abstract

Background: Mobile Therapeutic Attention for Patients with Treatment-Resistant Schizophrenia (m-RESIST) is an EU Horizon 2020-funded project aimed at designing and validating an innovative therapeutic program for treatment-resistant schizophrenia. The program exploits information from mobile phones and wearable sensors for behavioral tracking to support intervention administration. Objective: To systematically review original studies on sensor-based mHealth apps aimed at uncovering associations between sensor data and symptoms of psychiatric disorders in order to support the m-RESIST approach to assess effectiveness of behavioral monitoring in therapy. Methods: A systematic review of the English-language literature, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, was performed through Scopus, PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials databases. Studies published between September 1, 2009, and September 30, 2018, were selected. Boolean search operators with an iterative combination of search terms were applied. Results: Studies reporting quantitative information on data collected from mobile use and/or wearable sensors, and where that information was associated with clinical outcomes, were included. A total of 35 studies were identified; most of them investigated bipolar disorders, depression, depression symptoms, stress, and symptoms of stress, while only a few studies addressed persons with schizophrenia. The data from sensors were associated with symptoms of schizophrenia, bipolar disorders, and depression. Conclusions: Although the data from sensors demonstrated an association with the symptoms of schizophrenia, bipolar disorders, and depression, their usability in clinical settings to support therapeutic intervention is not yet fully assessed and needs to be scrutinized more thoroughly.

Published
2019

107. Pitkäaikaisen psykoosilääkityksen vaikutukset skitsofreniapotilaan aivojen rakenteeseen

Author

Huhtaniska, Sanna, Isohanni, Matti, Miettunen, Jouko, Koponen, Hannu, Jääskeläinen, Erika, Psykiatrian osasto, Clinicum, Helsingin yliopisto, and HUS Psykiatria

Subjects
+drug therapy, GeneralLiterature_INTRODUCTORYANDSURVEY, 317 Farmasia, Brain, +drug effects, Basal Ganglia, +pathology, Parietal Lobe, Chronic Disease, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Disease Progression, Schizophrenia, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), 3112 Neurotieteet, Antipsychotic Agents, 3124 Neurologia ja psykiatria
Abstract

English summary

Published
2019

111. Early environmental factors and somatic comorbidity in schizophrenia and nonschizophrenic psychoses: A 50-year follow-up of the Northern Finland Birth Cohort 1966

Author

Korpela, Hanna, primary, Miettunen, Jouko, additional, Rautio, Nina, additional, Isohanni, Matti, additional, Järvelin, Marjo-Riitta, additional, Jääskeläinen, Erika, additional, Auvinen, Juha, additional, Keinänen-Kiukaanniemi, Sirkka, additional, Nordström, Tanja, additional, and Seppälä, Jussi, additional

Published
2020
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112. Coping with institutional life at the old people's therapeutic community

Author

Isohanni, Matti

Subjects
Nursing home patients -- Social aspects, Adjustment (Psychology) -- Research, Aged -- Care and treatment, Psychology and mental health
Abstract

A RESEARCH PROJECT at a Finnish old people's home was carried out in 1983-1989, its aim being to explore whether therapeutic community principles can be applied to the institutional care of the elderly. Some aged seemed to adapt better to the community than others. In 1987 the group 'excellent coping in institution' (N = 14) was formulated for this study, on the basis of favorable outcome, good adaptation to aging, nonproblematic behavior and a high subjective satisfaction with life. Using logistic regression analysis, the properties of this group were compared with the group 'problem coping in institution' (N = 32). The following variables discriminated the excellent coping group best: therapeutic community activity, current mental health, and a socio-economically deprived childhood. This result suggested that active and mentally strong elderly coped better with the 'homelike' therapeutic community method executed between 1983-87, which focused only on a pleasant atmosphere in which the old people could live together. Therefore the treatment policy has been partially reorganized since 1987, so as to include special attention for passive and mentally fragile residents. The modified therapeutic community that was developed seems to help coping in geriatric institutions if its working methods permit 1) active participation, 2) passive rest and reminiscence, and 3) support, holding, and even psychiatric intervention.

Published
1990

114. Offspring of Depressed Mothers

Author

Veijola, Juha, Maki, Pirjo, Joukamaa, Matti, Jarvelin, Marjo-Riirta, Rantakallio, Paula, and Isohanni, Matti

Published
1998

119. Medication management of antipsychotic treatment in schizophrenia—A narrative review.

Author

Isohanni, Matti, Jääskeläinen, Erika, Miller, Brian J., Hulkko, Anja, Tiihonen, Jari, Möller, Hans‐Jurgen, Hartikainen, Sirpa, Huhtaniska, Sanna, and Lieslehto, Johannes

Subjects
*MEDICATION therapy management, *ARIPIPRAZOLE, *ANTIPSYCHOTIC agents, *SCHIZOPHRENIA, *BRAIN chemistry, *DRUG efficacy
Abstract

Background/Objective: The risk‐benefit ratio of antipsychotics in schizophrenia depends primarily on their effect on brain chemistry. An important factor influencing the efficacy of prescribed drugs is medication management, which can be defined as an ongoing process to manage and monitor the recommended use of antipsychotics to facilitate their cost‐effective, adherent, and acceptable use. Materials: We reviewed narratively relevant literature that examined the medication management of antipsychotics in schizophrenia based on a search of PubMed, Scopus, Web of Science, PsycARTICLES, and Cochrane in May 2020. We also included controlled interventional studies with a follow‐up period of at least 2 years. Result: Based on the previous literature, there is no unified approach for optimal medication management, but multiple useful strategies are presented for individual patients, prescribers, and organizations. Conclusions: Systematic medication management may improve the risk‐benefit balance of antipsychotics by achieving the lowest effective dose, minimizing adverse effects, and improving adherence. There is a need for well‐designed naturalistic studies and clinical trials to optimize management in schizophrenia. [ABSTRACT FROM AUTHOR]

Published
2021
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120. Mobile therapeutic attention for treatment-resistant schizophrenia (m-RESIST) : a prospective multicentre feasibility study protocol in patients and their caregivers

Author

Alonso, Anna, Rubinstein, Katya, Corripio, Iluminada, Jaaskelainen, Erika, Seppälä, Annika, Vella, Vincenzo Alberto, Caro-Mendivelso, Johanna, Caspi, Asaf, Isohanni, Matti, Unoka, Zsolt, Van der Graff, Shenja, Farkas, Kinga, Huerta-Ramos, Elena, Marcó-García, Silvia, Stevens, Matthias, Coenen, Tanguy, Hospedales, Margarita, Berdún, Jesús, Grasa-Bello, Eva, Universitat Autònoma de Barcelona, Studies in Media, Innovation and Technology, and Communication Sciences

Subjects
Male, Cost-Benefit Analysis, Mhealth, mobile device based intervention, feasibility, 0302 clinical medicine, Outcome Assessment, Health Care, Protocol, Medicine, Multicenter Studies as Topic, 030212 general & internal medicine, Prospective Studies, psychosis, mHealth, media_common, Medicine(all), Ethics Committees, Feasibility, General Medicine, Telemedicine, mhealth, 3. Good health, Mental Health, Caregivers, Research Design, Female, Adult, medicine.medical_specialty, Mobile device based intervention, Schizophrenia (object-oriented programming), Treatment-resistant schizophrenia, 03 medical and health sciences, Young Adult, Nursing, treatment-resistant schizophrenia, Intervention (counseling), media_common.cataloged_instance, Humans, European union, Protocol (science), business.industry, Public health, Usability, Patient Acceptance of Health Care, Psychosis, Schizophrenia, Feasibility Studies, Treatment resistant schizophrenia, business, 030217 neurology & neurosurgery, Program Evaluation
Abstract

IntroductionTreatment-resistant schizophrenia (TRS) is a severe form of schizophrenia. In the European Union, approximately 40% of people with schizophrenia have TRS. Factors such as the persistence of positive symptoms or higher risk of comorbidities leave clinicians with a complex scenario when treating these patients. Intervention strategies based on mHealth have demonstrated their ability to support and promote self-management-based strategies. Mobile therapeutic attention for treatment-resistant schizophrenia(m-RESIST), an innovative mHealth solution based on novel technology and offering high modular and flexible functioning, has been developed specifically for patients with TRS and their caregivers. As intervention in TRS is a challenge, it is necessary to perform a feasibility study before the cost-effectiveness testing stage.Methods and analysisThis manuscript describes the protocol for a prospective multicentre feasibility study in 45 patients with TRS and their caregivers who will be attended in the public health system of three localities: Hospital Santa Creu Sant Pau (Spain), Semmelweis University (Hungary) and Gertner Institute & Sheba Medical Center (Israel). The primary aim is to investigate the feasibility and acceptability of the m-RESIST solution, configured by three mHealth tools: an app, wearable and a web-based platform. The solution collects data about acceptability, usability and satisfaction, together with preliminary data on perceived quality of life, symptoms and economic variables. The secondary aim is to collect preliminary data on perceived quality of life, symptoms and economic variables.Ethics and disseminationThis study protocol, funded by the Horizon 2020 Programme of the European Union, has the approval of the ethics committees of the participating institutions. Participants will be fully informed of the purpose and procedures of the study, and signed inform consents will be obtained. The results will be published in peer-reviewed journals and presented in scientific conferences to ensure widespread dissemination.Trial registration numberNCT03064776; Pre-results.

Published
2018

121. Hoitoresistentin skitsofrenian hoitomahdollisuudet

Author

Jääskeläinen, Erika, Isohanni, Matti, Seppälä, Jussi, Seppälä, Annika, Miettunen, Jouko, Koponen, Hannu, HYKS erva, Psykiatrian osasto, Helsingin yliopisto, Clinicum, and HUS Psykiatria

Subjects
education, 3124 Neurologia ja psykiatria
Published
2018

124. T78. LONG-TERM PROGNOSIS OF SCHIZOPHRENIA - RESULTS FROM THE NORTHERN FINLAND BIRTH COHORT 1966

Author

Jääskeläinen, Erika, primary, Penttilä, Matti, additional, Moilanen, Jani, additional, Haapea, Marianne, additional, Hulkko, Anja, additional, Rannikko, Irina, additional, Rautio, Nina, additional, Nordström, Tanja, additional, Käkelä, Juha, additional, Seppälä, Annika, additional, Immonen, Johanna, additional, Korpela, Hanna, additional, Seppälä, Jussi, additional, Murray, Graham, additional, Koponen, Hannu, additional, Isohanni, Matti, additional, and Miettunen, Jouko, additional

Published
2018
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126. Antipsychotic and benzodiazepine use and brain morphology in schizophrenia and affective psychoses - Systematic reviews and birth cohort study

Author

Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada, Academy of Finland, Huhtaniska, Sanna, korkala, Likka, Heikka, Tuomas, Björnholm, Lassi, Lehtiniemi, Heli, Hulkko, Anja P., Moilanen, Jani S., Tohka, Jussi, Manjón Herrera, José Vicente, Coupé, Pierrick, Kiviniemi, Vesa, Isohanni, Matti, Koponen, Hannu, Murray, Graham K., Miettunen, Jouko, Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada, Academy of Finland, Huhtaniska, Sanna, korkala, Likka, Heikka, Tuomas, Björnholm, Lassi, Lehtiniemi, Heli, Hulkko, Anja P., Moilanen, Jani S., Tohka, Jussi, Manjón Herrera, José Vicente, Coupé, Pierrick, Kiviniemi, Vesa, Isohanni, Matti, Koponen, Hannu, Murray, Graham K., and Miettunen, Jouko

Abstract

[EN] The aim of this paper was to investigate differences in brain structure volumes between schizophrenia and affective psychoses, and whether cumulative lifetime antipsychotic or benzodiazepine doses relate to brain morphology in these groups. We conducted two systematic reviews on the topic and investigated 44 schizophrenia cases and 19 with affective psychoses from the Northern Finland Birth Cohort 1966. The association between lifetime antipsychotic and benzodiazepine dose and brain MRI scans at the age of 43 was investigated using linear regression. Intracranial volume, sex, illness severity, and antipsychotic/benzodiazepine doses were used as covariates. There were no differences between the groups in brain structure volumes. In schizophrenia, after adjusting for benzodiazepine dose and symptoms, a negative association between lifetime antipsychotic dose and the nucleus accumbens volume remained. In affective psychoses, higher lifetime benzodiazepine dose associated with larger volumes of total gray matter and hippocampal volume after controlling for antipsychotic use and symptoms. It seems that in addition to antipsychotics, the severity of symptoms and benzodiazepine dose are also associated with brain structure volumes. These results suggest, that benzodiazepine effects should also be investigated also independently and not only as a confounder.

Published
2018

131. Sequence variants at CHRNB3?€'CHRNA6 and CYP2A6 affect smoking behavior

Author

Thorgeirsson, Thorgeir E, Gudbjartsson, Daniel F, Surakka, Ida, Vink, Jacqueline M, Amin, Najaf, Geller, Frank, Sulem, Patrick, Rafnar, Thorunn, Esko, Tõnu, Walter, Stefan, Gieger, Christian, Rawal, Rajesh, Mangino, Massimo, Prokopenko, Inga, Mägi, Reedik, Keskitalo, Kaisu, Gudjonsdottir, Iris H, Gretarsdottir, Solveig, Stefansson, Hreinn, Thompson, John R, Aulchenko, Yurii S, Nelis, Mari, Aben, Katja K, den Heijer, Martin, Dirksen, Asger, Ashraf, Haseem, Soranzo, Nicole, Valdes, Ana M, Steves, Claire, Uitterlinden, André G, Hofman, Albert, Tönjes, Anke, Kovacs, Peter, Hottenga, Jouke Jan, Willemsen, Gonneke, Vogelzangs, Nicole, Döring, Angela, Dahmen, Norbert, Nitz, Barbara, Pergadia, Michele L, Saez, Berta, De Diego, Veronica, Lezcano, Victoria, Garcia-Prats, Maria D, Ripatti, Samuli, Perola, Markus, Kettunen, Johannes, Hartikainen, Anna-Liisa, Pouta, Anneli, Laitinen, Jaana, Isohanni, Matti, Huei-Yi, Shen, Allen, Maxine, Krestyaninova, Maria, Hall, Alistair S, Jones, Gregory T, van Rij, Andre M, Mueller, Thomas, Dieplinger, Benjamin, Haltmayer, Meinhard, Jonsson, Steinn, Matthiasson, Stefan E, Oskarsson, Hogni, Tyrfingsson, Thorarinn, Kiemeney, Lambertus A, Mayordomo, Jose I, Lindholt, Jes S, Pedersen, Jesper Holst, Franklin, Wilbur A, Wolf, Holly, Montgomery, Grant W, Heath, Andrew C, Martin, Nicholas G, Madden, Pamela A F, Giegling, Ina, Rujescu, Dan, Järvelin, Marjo-Riitta, Salomaa, Veikko, Stumvoll, Michael, Spector, Tim D, Wichmann, H-Erich, Metspalu, Andres, Samani, Nilesh J, Penninx, Brenda W, Oostra, Ben A, Boomsma, Dorret I, Tiemeier, Henning, van Duijn, Cornelia M, Kaprio, Jaakko, Gulcher, Jeffrey R, McCarthy, Mark I, Peltonen, Leena, Thorsteinsdottir, Unnur, and Stefansson, Kari

Published
2010
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132. M89. Long-Term Antipsychotic and Benzodiazepine Use and Brain Volume Changes in Schizophrenia: The Northern Finland Birth Cohort 1966 Study

Author

Huhtaniska, Sanna, primary, Jääskeläinen, Erika, additional, Heikka, Tuomas, additional, Moilanen, Jani S., additional, Lehtiniemi, Heli, additional, Tohka, Jussi, additional, Manjón, José V., additional, Coupe, Pierrick, additional, Björnholm, Lassi, additional, Koponen, Hannu, additional, Veijola, Juha, additional, Isohanni, Matti, additional, Kivinieim, Vesa, additional, Murray, Graham K., additional, and Miettunen, Jouko, additional

Published
2017
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133. Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study

Author

Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada, Banco Santander, University of Oulu, Academy of Finland, Orion Research Foundation, Sigrid Jusélius Foundation, Universidad Carlos III de Madrid, Jalmari and Rauha Ahokas Foundation, Brain and Behavior Research Foundation, Ministerio de Economía y Competitividad, Ministerio de Educación, Cultura y Deporte, Huhtaniska, Sanna, Jaaskelainen, Erika, Heikka, Tuomas, Moilanen, Jani S., Lehtiniemi, Heli, Tohka, Jussi, Manjón Herrera, José Vicente, Coupe, Pierrick, Bjornholm, Lassi, Koponen, Hannu, Veijola, Juha, Isohanni, Matti, Kiviniemi, Vesa, Murray, Graham K., Miettunen, Jouko, Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada, Banco Santander, University of Oulu, Academy of Finland, Orion Research Foundation, Sigrid Jusélius Foundation, Universidad Carlos III de Madrid, Jalmari and Rauha Ahokas Foundation, Brain and Behavior Research Foundation, Ministerio de Economía y Competitividad, Ministerio de Educación, Cultura y Deporte, Huhtaniska, Sanna, Jaaskelainen, Erika, Heikka, Tuomas, Moilanen, Jani S., Lehtiniemi, Heli, Tohka, Jussi, Manjón Herrera, José Vicente, Coupe, Pierrick, Bjornholm, Lassi, Koponen, Hannu, Veijola, Juha, Isohanni, Matti, Kiviniemi, Vesa, Murray, Graham K., and Miettunen, Jouko

Abstract

[EN] High doses of antipsychotics have been associated with loss in cortical and total gray matter in schizophrenia. However, previous imaging studies have not taken benzodiazepine use into account, in spite of evidence suggesting adverse effects such as cognitive impairment and increased mortality. In this Northern Finland Birth Cohort 1966 study, 69 controls and 38 individuals with schizophrenia underwent brain MRI at the ages of 34 and 43 years. At baseline, the average illness duration was over 10 years. Brain structures were delineated using an automated volumetry system, volBrain, and medication data on cumulative antipsychotic and benzodiazepine doses were collected using medical records and interviews. We used linear regression with intracranial volume and sex as covariates; illness severity was also taken into account. Though both medication doses associated to volumetric changes in subcortical structures, after adjusting for each other and the average PANSS total score, higher scan-interval antipsychotic dose associated only to volume increase in lateral ventricles and higher benzodiazepine dose associated with volume decrease in the caudate nucleus. To our knowledge, there are no previous studies reporting associations between benzodiazepine dose and brain structural changes. Further studies should focus on how these observations correspond to cognition and functioning.

Published
2017

134. Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review

Author

Jääskeläinen, Erika, Haapea, Marianne, Rautio, Nina, Juola, Pauliina, Penttilä, Matti, Nordström, Tanja, Rissanen, Ina, Husa, Anja, Keskinen, Emmi, Marttila, Riikka, Filatova, Svetlana, Paaso, Tiina-Mari, Koivukangas, Jenni, Moilanen, Kristiina, Isohanni, Matti, and Miettunen, Jouko

Subjects
Article Subject, mental disorders, behavioral disciplines and activities
Abstract

Birth cohort designs are useful in studying adult disease trajectories and outcomes, such as schizophrenia. We review the schizophrenia research performed in the Northern Finland Birth Cohort 1966 (NFBC 1966), which includes 10,934 individuals living in Finland at 16 years of age who have been monitored since each mother’s mid-pregnancy. By the age of 44, 150 (1.4%) had developed schizophrenia. There are 77 original papers on schizophrenia published from the NFBC 1966. The early studies have found various risk factors for schizophrenia, especially related to pregnancy and perinatal phase. Psychiatric and somatic outcomes were heterogeneous, but relatively poor. Mortality in schizophrenia is high, especially due to suicides. Several early predictors of outcomes have also been found. Individuals with schizophrenia have alterations in brain morphometry and neurocognition, and our latest studies have found that the use of high lifetime doses of antipsychotics associated with these changes. The schizophrenia research in the NFBC 1966 has been especially active for 20 years, the prospective study design and long follow-up enabling several clinically and epidemiologically important findings. When compared to other birth cohorts, the research in the NFBC 1966 has offered also unique findings on course and outcome of schizophrenia.

Published
2015
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135. What do we know about treatment-resistant schizophrenia?

Author

University of Helsinki, Clinicum, Seppälä, Annika, Molins, Conrad, Miettunen, Jouko, Hirvonen, Noora, Corripio, Iluminada, Juola, Teija, Isohanni, Matti, Koponen, Hannu, Moilanen, Jani, Seppälä, Jussi, Jääskeläinen, Erika, University of Helsinki, Clinicum, Seppälä, Annika, Molins, Conrad, Miettunen, Jouko, Hirvonen, Noora, Corripio, Iluminada, Juola, Teija, Isohanni, Matti, Koponen, Hannu, Moilanen, Jani, Seppälä, Jussi, and Jääskeläinen, Erika

Published
2016

136. Search for protective factors for psychosis – a population‐based sample with special interest in unaffected individuals with parental psychosis

Author

Keskinen, Emmi, primary, Marttila, Riikka, additional, Koivumaa‐Honkanen, Heli, additional, Moilanen, Kristiina, additional, Keinänen‐Kiukaanniemi, Sirkka, additional, Timonen, Markku, additional, Isohanni, Matti, additional, McGrath, John, additional, Miettunen, Jouko, additional, and Jääskeläinen, Erika, additional

Published
2016
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137. The C9ORF72 expansion sizes in patients with psychosis

Author

Solje, Eino, primary, Miettunen, Jouko, additional, Marttila, Riikka, additional, Helisalmi, Seppo, additional, Laitinen, Marjo, additional, Koivumaa-Honkanen, Heli, additional, Isohanni, Matti, additional, Hiltunen, Mikko, additional, Jääskeläinen, Erika, additional, and Remes, Anne M., additional

Published
2016
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138. Search for protective factors for psychosis – a population‐based sample with special interest in unaffected individuals with parental psychosis.

Author

Moilanen, Kristiina, Isohanni, Matti, Keskinen, Emmi, Marttila, Riikka, Miettunen, Jouko, Jääskeläinen, Erika, McGrath, John, Timonen, Markku, Keinänen‐Kiukaanniemi, Sirkka, and Koivumaa‐Honkanen, Heli

Subjects
*PSYCHOSES, *PARENTAL influences, *SCHIZOPHRENIA risk factors, *SCHIZOPHRENIA in children, *GENETICS
Abstract

Abstract: Aim: To find factors that are associated with not having psychotic illness in a prospective general population sample, with a special interest in individuals with parental psychosis. Methods: Data from the Northern Finland Birth Cohort 1966 (n = 10 458) and several registers were used to detect individuals with and without parental psychosis. Altogether, 594 persons had parent(s) with psychosis and 48 of them also had psychosis subsequently. Variables related to pregnancy and birth, family and childhood, health and habits in adolescence, school performance and physical activity were studied to identify determinants of unaffected status among individuals with and without parental psychosis. Results: In the parental psychosis group, the unaffected persons had more likely a mother who was non‐depressed during pregnancy, and who worked outside the home or studied than among those who developed psychosis. Conclusions: Protective factors for psychosis were surprisingly few in this sample. These factors were related to the mother's non‐depressed mood and the mother's work outside the home or studies. This could relate to better health and functioning of a mother. This work highlights the need for more research on protective factors for psychosis in order to identify methods for prevention of psychosis. [ABSTRACT FROM AUTHOR]

Published
2018
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139. Predictors of Long-Term Change in Adult Cognitive Performance: Systematic Review and Data from the Northern Finland Birth Cohort 1966

Author

Rannikko, Irina, primary, Jääskeläinen, Erika, additional, Miettunen, Jouko, additional, Ahmed, Anthony O., additional, Veijola, Juha, additional, Remes, Anne M., additional, Murray, Graham K., additional, Husa, Anja P., additional, Järvelin, Marjo-Riitta, additional, Isohanni, Matti, additional, and Haapea, Marianne, additional

Published
2016
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141. Aberrant Functional Connectivity in the Default Mode and Central Executive Networks in Subjects with Schizophrenia – A Whole-Brain Resting-State ICA Study

Author

Littow, Harri, primary, Huossa, Ville, additional, Karjalainen, Sami, additional, Jääskeläinen, Erika, additional, Haapea, Marianne, additional, Miettunen, Jouko, additional, Tervonen, Osmo, additional, Isohanni, Matti, additional, Nikkinen, Juha, additional, Veijola, Juha, additional, Murray, Graham, additional, and Kiviniemi, Vesa J., additional

Published
2015
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142. Author's reply

Author

Penttilä, Matti, primary, Jääskeläinen, Erika, additional, Hirvonen, Noora, additional, Isohanni, Matti, additional, and Miettunen, Jouko, additional

Published
2014
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143. Longitudinal Changes in Total Brain Volume in Schizophrenia: Relation to Symptom Severity, Cognition and Antipsychotic Medication

Author

Veijola, Juha, primary, Guo, Joyce Y., additional, Moilanen, Jani S., additional, Jääskeläinen, Erika, additional, Miettunen, Jouko, additional, Kyllönen, Merja, additional, Haapea, Marianne, additional, Huhtaniska, Sanna, additional, Alaräisänen, Antti, additional, Mäki, Pirjo, additional, Kiviniemi, Vesa, additional, Nikkinen, Juha, additional, Starck, Tuomo, additional, Remes, Jukka J., additional, Tanskanen, Päivikki, additional, Tervonen, Osmo, additional, Wink, Alle-Meije, additional, Kehagia, Angie, additional, Suckling, John, additional, Kobayashi, Hiroyuki, additional, Barnett, Jennifer H., additional, Barnes, Anna, additional, Koponen, Hannu J., additional, Jones, Peter B., additional, Isohanni, Matti, additional, and Murray, Graham K., additional

Published
2014
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145. Poster #T116 INTERACTION BETWEEN PARENTAL PSYCHOSIS AND DELAYS ON EARLY MOTOR DEVELOPMENTAL MILESTONES IN SCHIZOPHRENIA – THE NORTHERN FINLAND 1966 BIRTH COHORT STUDY

Author

Keskinen, Emmi S.J., primary, Marttila, Anna, additional, Kyllönen, Merja, additional, Jones, P.B., additional, Murray, G.K., additional, Moilanen, Kristiina, additional, Koivumaa-Honkanen, Heli, additional, Mäki, Pirjo H., additional, Isohanni, Matti, additional, Jääskeläinen, Erika, additional, and Miettunen, Jouko, additional

Published
2014
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147. Poster #T99 THE RELATION BETWEEN LIFETIME ANTIPSYCHOTIC MEDICATION AND COGNITIVE PERFORMANCE IN SCHIZOPHRENIA AT AGE 43 YEARS – THE NORTHERN FINLAND BIRTH COHORT 1966

Author

Husa, Anja, primary, Moilanen, Jani, additional, Murray, Graham, additional, Haapea, Marianne, additional, Rannikko, Irina, additional, Barnett, Jennifer, additional, Isohanni, Matti, additional, Koponen, Hannu, additional, Miettunen, Jouko, additional, and Jääskeläinen, Erika, additional

Published
2014
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