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Mientras las tiradas de los periódicos de papel no dejan de reducirse, su influencia se traslada al ámbito digital iniciando nuevas formas de relacionarse con sus lectores. Con el objetivo de determinar la relevancia en el entorno digital de las grandes cabeceras españolas con décadas de tradición en papel, el presente trabajo mide el engagement obtenido mediante un análisis detallado de la presencia en la red social Twitter de los veinte diarios más leídos en España. Como principal conclusión destaca la comprobación de que el mayor engagement aparece en cabeceras locales, pese a que el mayor alcance corresponde a la prensa nacional. Los resultados constatan la necesidad de incorporar nuevas medidas para el control de la eficacia empresarial de la industria de la información.

This comprehensive review aimed (1) to characterize the sub- and supragingival microbiome in patients with biofilm-induced gingivitis (including experimental gingivitis), (2) to assess its stability and evolution over time, and (3) to assess the impact of biofilm control measures on this stability. An electronic search of the MEDLINE®/PubMed® database until December 2023 was conducted. NCBI Taxonomy, eHOMD 16S rRNA Reference Sequence, and Tree Version 15.23 databases were used to standardize taxonomic nomenclature. Out of 89 papers initially retrieved, 14 studies were finally included: 11 using experimental gingivitis as a model and three randomized clinical trials evaluating the impact of biofilm control measures. Among them, five characterized the subgingival microbiome, nine the supragingival microbiome, and one both the sub- and supragingival microbiome. In addition, five studies evaluated the effect of toothpaste, and four studies evaluated the effect of mouth rinses. The diversity and structure of the microbiome differed significantly between patients with periodontal health and those with biofilm-induced gingivitis (including experimental gingivitis). Those differences were not reversed through conventional oral hygiene measures. Specific antiseptic agents, especially if delivered as mouth rinses, may have an impact on the supra- and subgingival microbiome in gingivitis.

In recent years, the quest to advance fuel cell technologies has intensified, driven by the imperative to reduce reliance on hydrocarbon-derived fuels and mitigate pollutant emissions. Proton exchange membranes are a critical material of fuel cell technologies. The potential of ionic liquid-based polymer inclusion membranes or ionogels for proton exchange membrane fuel cells (PEMFCs) has recently appeared. Thermal stability, SEM-EDX characterization, NMR and IR characterization, thermogravimetric analysis, ion exchange capacity, and water uptake are key properties of these membranes which need to be investigated. In this work, ionogel based on quaternary ammonium salts, such as [N8,8,8,1+][Cl−], [N8,8,8,1+][Br−], and [N8-10,8-10,8-10,1+][Cl−] in various compositions with poly(vinyl chloride) are extensively studied and characterized based on those key properties. The best properties were obtained when a quaternary ammonium cation was combined with a bromide anion. Finally, ionogels are tested in microbial fuel cells. Microbial fuel cells based on the ionogel reach a maximum of 147 mW/m2, which represents 55% of the reference membrane (Nafion 212). These results indicate that we still have the possibility of improvement through the appropriate selection of the cation and anion of the ionic liquid. Overall, the promise of ionogel membranes as a viable alternative in fuel cell applications has been demonstrated.

There has been growing interest in the use of numerous plant bioactive compounds (PBCs) in food and nutrition technology due to their properties that promote human health by reducing the risk of various serious diseases [...]

Fruit consumption guarantees the supply of most of the necessary nutrients for a complete and balanced diet, as it is a relevant source of vitamins, minerals, and antioxidants. In particular, pomegranate has very interesting medicinal properties, such as an anti-inflammatory effect and the protection of the cardiovascular system, among others. During pomegranate juice production, it appears cloudy and must be clarified to remove suspended solids such as colloids and high-molecular weight tannins. The membrane clarification process is a cost-effective alternative to the conventional methods, resulting in a high-quality product. In this work, the clarification of pomegranate juice using the Triple System Model F1 membrane module was carried out for the Mollar and Wonderful varieties with early and late maturity. Three ultrafiltration membranes with different molecular weight cut-off and different chemical compositions were used. The rejection coefficient and permeate flux (which represent the selectivity of the membranes and the process efficiency, respectively) were measured. GR-40PP showed the best results in terms of membrane selectivity and process efficiency, achieving adequate physicochemical juice parameters. Regarding the comparison of the maturity degree, in general terms, the Mollar variety showed better results. Ripe pomegranates showed greater selectivity, while the process efficiency was higher for the early samples.

Mycoplasma bovis (M. bovis) is one of the worldwide most important infectious agents involved in respiratory complex diseases (RCD). In Spain, the endemic presence of subtypes ST-2 and ST-3 with phenotypic differences linked to their susceptibility to fluoroquinolones opened the way to develop control strategies focused on previous diagnosis of the subtype and the use of directed therapies when M. bovis were involved in RCD. Surprisingly, microbiological studies conducted during 2023 evidenced for the first time the presence of Spanish isolates of a new polC-subtype, previously classified as ST-1, recovered from calves with respiratory symptoms and pneumonia in different areas of the country (n = 16). Curiously, the minimum inhibitory concentration (MIC) to a panel of antimicrobials revealed phenotypic differences between these ST-1 isolates when using fluoroquinolones (FLQ). There is no geographical correlation between MIC profiles even for a set of 8 isolates recovered from different animals in the same flock. Sequencing of 4 genes (gyrA, gyrB, parC and parE) encoding quinolone resistance-determining regions (QRDR) evidenced the presence of accumulate mutations in 2 ST-1 isolates with high FLQ MICs, but not in all them (n = 3), thus suggesting that, as previously recorded for ST-2 isolates, other mechanisms should be involved in the acquisition of resistence to these antimicrobials. Additionally, as previously detected in the Spanish ST-2 and ST-3, subtype ST-1 isolates are also resistant to macrolides or lincosamides.

Article accepted. The article will be published here soon. Pending final quality checks.

La fotografía ha constituido desde su invención un medio privilegiado para registrar bienes patrimoniales y manifestaciones culturales. Este artículo estudia la obra de Tomás Camarillo (1879-1954), que testimonió de manera exhaustiva la provincia de Guadalajara, su naturaleza y cultura. Con el fin de estimar el valor de su aportación documental y creativa, se analizan fotografías y ejemplares inéditos. Dentro del amplio repertorio visual, se presta especial atención a paisajes, vistas de pueblos, obras públicas, escenas costumbristas, retratos y manifestaciones del patrimonio inmaterial. También se reflexiona sobre los usos documentales, turísticos y políticos de la colección.

In recent years, autonomous electric vehicles (A-EVs) have attracted the attention of academia and industry. In urban mobility, this topology requires consensus to control behaviours under swarm robotics. Although several model-based solutions have successfully enhanced accuracy and overcome some limitations, specific technological, methodological, and security issues remain. In this study, we systematically reviewed existing research related to swarm intelligence and multi-agent systems in urban mobility. Based on the obtained results, we propose a new directed acyclic graph-based multilayer architecture model. Furthermore, we propose a long short-term memory recurrent neural network model to make predictions. To validate the model, available data based on real traffic in Madrid (Spain) were considered.

The intriguing thanatosis was observed for the second time for a member of the family Chelodesmidae. This behavior was recorded for the species Pseudoleptodesmus rubescens (Gervais, 1836), in the municipality of Magé, state of Rio de Janeiro, Brazil.

Inflammation is a tightly coordinated response of the host immune system to bacterial and viral infections, triggered by the production of inflammatory cytokines. Sepsis is defined as a systemic inflammatory response followed by immunosuppression of the host and organ dysfunction. This imbalance of the immune response increases the risk of mortality of patients with sepsis, making it a major problem for critical care units worldwide. The P2X7 receptor plays a crucial role in activating the immune system by inducing the activation of peripheral blood mononuclear cells. In this study, we analyzed a cohort of abdominal origin septic patients and found that the expression of the P2X7 receptor in the plasma membrane is elevated in the different subsets of lymphocytes. We observed a direct relationship between the percentage of P2X7-expressing lymphocytes and the early inflammatory response in sepsis. Additionally, in patients whose lymphocytes presented a higher percentage of P2X7 surface expression, the total lymphocytes populations proportionally decreased. Furthermore, we found a correlation between elevated soluble P2X7 receptors in plasma and inflammasome-dependent cytokine IL-18. In summary, our work demonstrates that P2X7 expression is highly induced in lymphocytes during sepsis, and this correlates with IL-18, along with other inflammatory mediators such as IL-6, IL-8, and procalcitonin.

Se presentan los resultados de los análisis del registro arqueológico y las cronologías del sitio El Diablito, ubicado en la cuenca de Chuquis, faldeo oriental de la Sierra de Velasco, norte de la provincia de La Rioja. Se pretende reconocer las dinámicas de ocupación espacial y los usos de los dos sectores del sitio: un alero con pinturas rupestres y un conjunto de estructuras residenciales. Para ello, se caracteriza el patrón arquitectónico y el arte rupestre. Se estudia la alfarería y los restos faunísticos procedentes de las excavaciones y se obtienen fechados radiocarbónicos. A su vez, se realizan análisis espaciales intrasitio para evaluar articulaciones e interacciones entre ambos sectores. Se propone que los espacios “público” y “privado” fueron ocupados de manera integrada hacia el 800 d.C. Sin embargo, el alero habría sido reutilizado y resignificado, al menos, hasta comienzos del segundo milenio.

El objetivo de este estudio fue analizar el impacto de un programa gamificado en las clases de Educación Física sobre las regulaciones motivacionales y las calificaciones de los estudiantes de secundaria en comparación con un planteamiento tradicional de enseñanza. La muestra se compuso por los 102 estudiantes de 4.º de ESO (16.7 ± 0.43 años) de un mismo centro concertado de la provincia de Barcelona, los cuales se dividieron en un grupo experimental (gamificación) (n = 51, 18 chicos y 33 chicas) y otro de comparación (planteamiento tradicional) (n = 51, 20 chicos y 31 chicas). El estudio siguió un diseño cuasi experimental, pretest postest (ocho semanas), a partir de la utilización de la Escala del Locus Percibido de Causalidad (PLOC) y el análisis de las calificaciones finales. Solo el programa gamificado logró cambios significativos en la motivación intrínseca, la desmotivación y las regulaciones identificada, introyectada y externa, aunque en mayor medida en la intrínseca. Estos estudiantes también obtuvieron unas calificaciones finales significativamente más altas. En definitiva, la aplicación de un programa gamificado como modelo pedagógico emergente puede generar efectos positivos entre el alumnado a nivel motivacional y de rendimiento académico.El objetivo de este estudio fue analizar el impacto de un programa gamificado en las clases de Educación Física sobre las regulaciones motivacionales y las calificaciones de los estudiantes de secundaria en comparación con un planteamiento tradicional de enseñanza. La muestra se compuso por los 102 estudiantes de 4.º de ESO (16.7 ± 0.43 años) de un mismo centro concertado de la provincia de Barcelona, los cuales se dividieron en un grupo experimental (gamificación) (n = 51, 18 chicos y 33 chicas) y otro de comparación (planteamiento tradicional) (n = 51, 20 chicos y 31 chicas). El estudio siguió un diseño cuasi experimental, pretest postest (ocho semanas), a partir de la utilización de la Escala del Locus Percibido de Causalidad (PLOC) y el análisis de las calificaciones finales. Solo el programa gamificado logró cambios significativos en la motivación intrínseca, la desmotivación y las regulaciones identificada, introyectada y externa, aunque en mayor medida en la intrínseca. Estos estudiantes también obtuvieron unas calificaciones finales significativamente más altas. En definitiva, la aplicación de un programa gamificado como modelo pedagógico emergente puede generar efectos positivos entre el alumnado a nivel motivacional y de rendimiento académico.

Chelodesmidae is one of the most species rich families within the Myriapoda. However, little is known regarding their association with caves. We provide a list of all Chelodesmidae taxa reported from caves, map their worldwide distribution, and discuss the troglomorphic features of the group. A total of 25 species and subspecies from 20 genera and 2 subfamilies have been recorded from 59 caves and cave systems in 11 countries. These numbers represent a surprisingly modest proportion (~3%) of the approximately 800 described species in the family. Records of cave-dwelling chelodesmids appear to be geographically biased with most taxa reported from the Neotropics, likely due to the greater diversity of the group in the region. The lack of published records from the Afrotropics can undoubtedly be attributed to low sampling efforts. In addition, many studies focusing on cave invertebrates, especially in the tropics, often fail to identify chelodesmid taxa to the species level, thus precluding their inclusion on checklists. The majority of the Chelodesmidae reported from caves do not display obvious adaptations to a subterranean lifestyle and are not troglomorphic. The five troglobitic taxa indicated in this study may represent relictual lineages suggesting that few, if any, radiations of chelodesmids within caves have occurred in the past. Increased efforts are needed to bridge the gap between our current understanding and the true diversity of the group in these fragile and threatened habitats, which is necessary to allow policy makers to prioritize appropriate and effective conservation efforts, including the protection of environments severely impacted by human activities.

ABSTRACT The millipede Chondromorpha xanthotricha, supposedly native to Sri Lanka and southern India, is considered a pantropical species occurring in Southeast Asia, North America, Mesoamerica, the Caribbean, Central America and northern South America. Here we report the first record of this species for Brazil, in the central Amazon region of the country, with taxonomic notes and images of male and female specimens.

During the last decade, the policy efforts aiming to tackle the NEET situation (young people who neither study nor work) have increased dramatically in the European Union. Meanwhile, many studies challenged those policies, showing how they failed due to lack of understanding the NEETs. Thus, we analyse the factors that influence the appearance, modification and elimination of a NEET identity. The results reveal the presence of a shared NEET identity in the countries with high NEET rates, despite the considerable differences in the countries’ and NEETs’ characteristics. The NEET rate stands out as the key factor influencing the NEET identity, showing that this identity depends more on economic cycles than on the specific country or its culture.

Abstract Background In the ongoing COVID-19 pandemic, advanced age is a risk factor for a severe clinical course of SARS-CoV-2 infection. Thus, older people may benefit in particular from booster doses with potent vaccines and research should focus on optimal vaccination schedules. In addition to each individual’s medical history, immunosenescence warrants further research in this population. This study investigates vaccine-induced immune response over 1 year. Methods/design EU-COVAT-1-AGED is a randomised controlled, adaptive, multicentre phase II protocol evaluating different booster strategies in individuals aged ≥75 years (n=600) already vaccinated against SARS-CoV-2. The initial protocol foresaw a 3rd vaccination (1st booster) as study intervention. The present modified Part B of this trial foresees testing of mRNA-1273 (Spikevax®) vs. BNT162b2 (Comirnaty®) as 4th vaccination dose (2nd booster) for comparative assessment of their immunogenicity and safety against SARS-CoV-2 wild-type and variants. The primary endpoint of the trial is to assess the rate of 2-fold antibody titre increase 14 days after vaccination measured by quantitative enzyme-linked immunosorbent assay (Anti-RBD-ELISA) against wild-type virus. Secondary endpoints include the changes in neutralising antibody titres (Virus Neutralisation Assay) against wild-type as well as against Variants of Concern (VOC) at 14 days and up to 12 months. T cell response measured by qPCR will be performed in subgroups at 14 days as exploratory endpoint. Biobanking samples are being collected for neutralising antibody titres against potential future VOC. Furthermore, potential correlates between humoral immune response, T cell response and neutralising capacity will be assessed. The primary endpoint analysis will be triggered as soon as for all patients the primary endpoint (14 days after the 4th vaccination dose) has been observed. Discussion The EU-COVAT-1-AGED trial Part B compares immunogenicity and safety of mRNA-1273 (Spikevax®) and BNT162b2 (Comirnaty®) as 4th SARS-CoV-2 vaccine dose in adults ≥75 years of age. The findings of this trial have the potential to optimise the COVID-19 vaccination strategy for this at-risk population. Trial registration ClinicalTrials.gov NCT05160766 . Registered on 16 December 2021. Protocol version: V06_0: 27 July 2022

Background: Chronic use of Angiotensin-converting enzyme (ACE) inhibitors (ACEi) and aldosterone-receptor blockers (ARB) is not associated with worse outcomes in patients with COVID-19. However, evidence on the impact of their discontinuation during hospital admission is scarce. Our aim was to determine whether withdrawal of ACEi, ARB and mineralocorticoid receptor antagonists (MRA) is associated with all-cause mortality in a real-life large cohort of patients with SARS-CoV-2 infection. Methods: Observational cohort study from a large referral center from 1 March 2020 to 20 April 2020. Withdrawal of renin-angiotensin-aldosterone system inhibitors was defined as the absence of any received dose during hospital admission in patients receiving chronic treatment. Prescriptions during admission were confirmed by data from the central pharmacy computerized system. Results: A total of 2042 patients (mean age 68.4±17.6, 57.1% male) with confirmed COVID-19 were included. During a median follow-up of 57 (21-55) days, 583 (28.6%) died. Prior to hospital admission 468 (22.9%), 343 (16.8%) and 83 (4.1%) patients were receiving ACEi, ARB and MRA respectively. During the study period, 216 (46.2%), 193 (56.3%) and 41 (49.4%) were withdrawn from the corresponding drug. After adjusting for age, cardiovascular risk factors, baseline comorbidities and in-hospital COVID-19 dedicated treatment, withdrawal of ACE inhibitors (hazard ration [HR] 1.48 [95% confidence interval –CI– 1.16-1.89]) and MRA (HR 2.01 [95% CI 1.30-3.10]) were shown to be independent predictors of all-cause mortality. No independent relationship between ARB withdrawal and mortality was observed. Conclusion: ACEi and MRA withdrawal were associated with higher mortality. Strong consideration should be given to not discontinuing these medications during hospital admission. Resumo: Introdução: O uso crónico de inibidores da ECA (IECA) e de antagonistas dos recetores de aldosterona (ARA) não está associado a resultados piores em doentes com Covid-19. No entanto, a evidência relativa ao impacto da sua retirada durante a admissão hospitalar é escassa. O nosso objetivo foi determinar se a retirada do IECA, ARA e antagonistas dos recetores dos mineralocorticóides (ARM) está associada à mortalidade por todas as causas numa grande coorte real de doentes com infeção por SRA-CoV-2. Métodos: Estudo coorte observacional a partir de um grande centro de referência de 1 de março de 2020 a 20 de abril de 2020. A retirada dos inibidores do sistema RAAS foi definida como a ausência de qualquer dose recebida durante a admissão hospitalar em doentes que recebem tratamento prolongado. As prescrições durante a admissão foram confirmadas por dados do sistema informático da farmácia central. Resultados: Um total de 2042 doentes (idade média de 68,4 ±17,6, 57,1% do sexo masculino) com COVID-19 confirmado foram incluídos. Durante um acompanhamento médio de 57 (21-55) dias, 583 (28,6%) morreram. Conclusão: A retirada do IECA e do ARM foi associada a uma mortalidade mais elevada. Deve ser dada grande atenção para não interromper estes medicamentos durante a admissão hospitalar.

All known photosynthetic cyanobacteria carry a cytochrome c6 protein that acts transferring electrons from cytochrome b6f complex to photosystem I, in photosynthesis, or cytochrome c oxidase, in respiration. In most of the cyanobacteria, at least one homologue to cytochrome c6 is found, the so-called cytochrome c6B or cytochrome c6C. However, the function of these cytochrome c6-like proteins is still unknown. Recently, it has been proposed a common origin of these proteins as well as the reclassification of the cytochrome c6C group as c6B, renaming the new joint group as cytochrome c6BC. Another homologue to cytochrome c6 has not been classified yet, the formerly called cytochrome c6-3, which is present in the heterocyst-forming filamentous cyanobacteria Nostoc sp. PCC 7119. In this work, we propose the inclusion of this group as an independent group in the genealogy of cytochrome c6-like proteins with significant differences from cytochrome c6 and cytochrome c6BC, with the proposed name cytochrome c6D. To support this proposal, new data about phylogeny, genome localisation and functional properties of cytochrome c6-like proteins is provided. Also, we have analysed the interaction of cytochrome c6-like proteins with cytochrome f by isothermal titration calorimetry and by molecular docking, concluding that c6-like proteins could interact with cytochrome b6f complex in a similar fashion as cytochrome c6. Finally, we have analysed the reactivity of cytochrome c6-like proteins with membranes enriched in terminal oxidases of cyanobacteria by oxygen uptake experiments, concluding that cytochrome c6D is able to react with the specific copper-oxidase of the heterocysts, the cytochrome c oxidase 2.

The environmental damage caused by air pollution has recently become the focus of city council policies. The concept of the green city has emerged as an urban solution by which to confront environmental challenges worldwide and is founded on air pollution levels that have increased meaningfully as a result of traffic in urban areas. Local governments are attempting to meet environmental challenges by developing public traffic policies such as air pollution protocols. However, several problems must still be solved, such as the need to link smart cars to these pollution protocols in order to find more optimal routes. We have, therefore, attempted to address this problem by conducting a study of local policies in the city of Madrid (Spain) with the aim of determining the importance of the vehicle routing problem (VRP), and the need to optimise a set of routes for a fleet. The results of this study have allowed us to propose a framework with which to dynamically implement traffic constraints. This framework consists of three main layers: the data layer, the prediction layer and the event generation layer. With regard to the data layer, a dataset has been generated from traffic data concerning the city of Madrid, and deep learning techniques have then been applied to this data. The results obtained show that there are interdependencies between several factors, such as weather conditions, air quality and the local event calendar, which have an impact on drivers’ behaviour. These interdependencies have allowed the development of an ontological model, together with an event generation system that can anticipate changes and dynamically restructure traffic restrictions in order to obtain a more efficient traffic system. This system has been validated using real data from the city of Madrid.

A classe Diplopoda corresponde a cerca de 12.000 espécies nominais. Indivíduos desta classe estão associados a quase todos os estratos do solo, contribuindo de maneira eficiente para a ciclagem de nutrientes. Algumas espécies são consideradas pragas agrícolas, amplamente distribuídas atráves de atividades humanas. No Brasil, são conhecidas 12 espécies introduzidas, com grande parte dessas originarias da Ásia e difundidas principalmente na região sudeste do país. Dentre essas, destacam-se Oxidus gracilis (C.L. Koch) e Orthomorpha coarctata (Saussure) (Polydesmida, Paradoxosomatidae), registradas para quase todas as regiões do Brasil, e Trigoniulus corallinus (Gervais) (Spirobolida, Pachybolidae), de ocorrência para o Norte, Nordeste e Sudeste. No entanto, mesmo essas sendo amplamente distribuídas, nenhuma tem registro até o momento para o estado do Maranhão. Nesta perspectiva, o presente trabalho tem como objetivo registrar pela primeira vez no estado do Maranhão a ocorrência destas espécies a partir de coletas em áreas urbanas do município de Códo, região ao leste do estado, durante os meses de janeiro e fevereiro de 2023. De modo geral, os indivíduos foram encontrados enterrados em camadas mais superficiais do solo ou associados a poças de água próximas da serrapilheira. A região apresenta grande diversidade vegetal, mas sem nenhuma unidade de conservação formulada até o momento, além de sofrer atualmente com o avanço de atividades extrativistas e de Silvicultura, podendo acarretar a perda da diversidade biológica em áreas ainda quase que inexploradas em relação a fauna.

The chelodesmid genus Dibolostethus Hoffman, 2009, the sole member of the tribe Dibolostethini, is reviewed. The genus contains the type species D. sicarius Hoffman, 2009 known only from the Los Rios Province, Ecuador, and two new species from the Tropical Andes, D. inopinatus Means, Bouzan & Ivanov sp. nov. from the Morona-Santiago Province, Ecuador and D. kattani Means, Bouzan, Martínez-Torres & Ivanov sp. nov. from the Valle del Cauca Department, Colombia. We redescribe D. sicarius and provide a revised diagnosis of the genus, images of diagnostic morphological characters, and a key to the males of Dibolostethus. In addition, we provide a summary and a distribution map of the Chelodesmidae of the Tropical Andes Biodiversity Hotspot.

The application of bacterial metagenomic analysis as a biomarker for cancer detection is emerging. Our aim was to discover gut microbiota signatures with potential utility in the diagnosis of colorectal cancer (CRC) and non-small cell lung cancer (NSCLC). A prospective study was performed on a total of 77 fecal samples from CRC and NSCLC patients and controls. DNA from stool was analyzed for bacterial genomic sequencing using the Ion Torrent™ technology. Bioinformatic analysis was performed using the QIIME2 pipeline. We applied logistic regression to adjust for differences attributable to sex, age, and body mass index, and the diagnostic accuracy of our gut signatures was compared with other previously published results. The feces of patients affected by different tumor types, such as CRC and NSCLC, showed a differential intestinal microbiota profile. After adjusting for confounders, Parvimonas (OR = 53.3), Gemella (OR = 6.01), Eisenbergiella (OR = 5.35), Peptostreptococcus (OR = 9.42), Lactobacillus (OR = 6.72), Salmonella (OR = 5.44), and Fusobacterium (OR = 78.9) remained significantly associated with the risk of CRC. Two genera from the Ruminococcaceae family, DTU089 (OR = 20.1) and an uncharacterized genus (OR = 160.1), were associated with the risk of NSCLC. Our two panels had better diagnostic capacity for CRC (AUC = 0.840) and NSLC (AUC = 0.747) compared to the application of two other published panels to our population. Thus, we propose a gut bacteria panel for each cancer type and show its potential application in cancer diagnosis.

This study shows the influence of soil salinity and irrigation dose on biomass production and its impact on some edaphic indicators and functions. For this purpose, an experiment was carried out in two representative soils from Murcia (SE Spain), one slightly saline (LS) and the other saline (S), where an oat–vetch green manure was intercalated between a spinach cycle and a coriander cycle; the latter being subjected to three different irrigation doses (deficient, optimum and surplus). Rapid response indicators (ECext, cations and anions in the soil solution, etc.) were monitored, as well as the material balances, in particular C and salts. Green manure and crop residues increased soil OC by 12.5% and reduced Na+ and NO3− concentrations. Total biomass production was also affected by salinity, both in oat–vetch, 35.9 and 31. 9 tm ha−1 in LS and S, respectively, and in the coriander crop, where the irrigation dose was decisive, obtaining around 29 tm ha−1 with the optimum and surplus doses and significantly lower amounts with the deficit dose: 20.4 tm ha−1 in LSD and 14. 0 in SD. Therefore, it is necessary to adjust the irrigation doses, since deficit irrigation significantly reduces production and the surplus does not lead to an increase with respect to the optimum, while also causing ions to leach to depth horizons, as is the case for NO3−, Cl− and Na+, with the consequent risk of contaminating the water table.

Purpose – Websites are the most important element of company strategy in the digital space. Therefore, establishing strategic management of online business is essential to improve firm connectedness and competitiveness and to achieve global company reach. This paper aims to propose the analysis of technical and content quality of websites to identify the main weaknesses and strengths of online business. Design/methodology/approach – An innovative measurement instrument called IWebQEI is designed to measure web quality level. This instrument is validated with data from 104 international companies. The results are used to verify whether there are quality differences between informative and e-commerce websites. Findings – The main findings indicate that e-commerce websites achieve greater levels of technical and content quality than informative sites, and companies implementing e-commerce pay more attention to the content quality dimension. In contrast, companies using an informative website are more focused on the technical quality dimension. Based on these results, practical insights are offered to improve the strategic management of e-commerce. Originality/value – Few studies have focused on analysing the technical and content quality of websites to identify the main weaknesses and strengths of online business. The results offer important theoretical and practical contributions for companies on how to manage their website to improve firm connectivity and competitiveness. Debilidades y fortalezas de los sitios web de marketing online Propósito – Los sitios web son el elemento más importante de la estrategia digital de la compañia. Una gestión estratégica del negocio online es esencial para mejorar su conectividad, competitividad y para conseguir su alcance global. Este trabajo propone el análisis de la calidad técnica y de contenido de sitios web para identificar las principales debilidades y fortalezas del negocio online. Metodología – Para medir el nivel de calidad web, se ha diseñado un innovador instrumento de medición, denominado IWebQEI. Este instrumento se valida con datos de 104 empresas internacionales. Los resultados se utilizan para comprobar si existen diferencias de calidad entre las webs informativas y los e-commerce. Resultados – Las resultados indican que los e-commerce alcanzan mayores niveles de calidad técnica y de contenido que las webs informativas, y las empresas que implementan un e-commerce prestan más atención a la calidad de contenido. En cambio, las empresas que implementan una web informativa se centran más en la calidad técnica. A partir de estos resultados se ofrecen ideas prácticas para mejorar la gestión estratégica del e-commerce. Originalidad – Pocos estudios analizan la calidad técnica y de contenido de los sitios web para identificar las principales debilidades y fortalezas del negocio online. Los resultados ofrecen importantes contribuciones teóricas y prácticas sobre cómo gestionar los sitios web para mejorar la conectividad y la competitividad de la compañia. 网络营销网站的弱点和优势 目的 – 企业网站是公司在数字空间中战略的最重要元素。因此, 建立在线业务本身的战略管理对于提高公司的连通性和竞争力以及实现公司的全球影响力至关重要。本文提出对企业网站的技术和内容质量进行分析, 以确定在线业务的主要弱点和优势。 设计/方法/途径 – 设计了一个创新的测量仪器, 称为IWebQEI, 用于测量网络质量水平。该仪器通过104家国际公司的数据进行验证。结果被用于检查信息网站和电子商务网站之间是否存在质量差异。 研究结果 – 主要研究结果表明, 总体而言, 电子商务网站的技术质量和内容质量水平高于信息类网站, 实施电子商务的公司更注重内容质量维度。相比之下, 实施信息型网站的公司则更注重技术质量维度。基于这些结果, 为改进电子商务的战略管理提供了实际的见解。 原创性 – 以前的研究很少关注分析企业网站的技术和内容质量, 以确定在线业务的主要弱点和优势。研究结果为企业提供了重要的理论和实践贡献, 即如何管理企业网站以提高公司的连通性和竞争力。

ABSTRACT The millipede species Taulidesmella tabatinga is known from the border of Brazil with Peru and Colombia, Iquitos (Peru), and environs of Manaus (Brazil). Based on freshly collected material during the rainy season in 2014 along the Amazon River upriver from its confluence with the Negro River, we report a new record of T. tabatinga in floodplain forests in the municipality of Alvarães, Amazonas state (Brazil), filling a gap of 1,000 km between its previously known occurrence points. This record indicates that T. tabatinga is likely widespread along both margins of the upper Amazon River, mostly associated with tree trunks and litter of riparian and floodplain forests.

The depletion of freshwater sources by indiscriminate industrial actions is one of the direct causes of the current water crisis. One of the emblematic cases of this problem is the Atacama Desert, a unique hyper-arid zone in which an extensive copper industry depletes its scarce freshwater reserves. This territory, occupied for millennia by indigenous groups, is experiencing a water crisis that threatens its very subsistence. This paper uses the ethnographic method and the Water Justice framework to approach the everyday and often invisible issues of this crisis within the Mamiña community. This Quechua community holds an ambivalent position in front of the copper mine project because of its control of the water rights, the economic interests of some of their members, and the role of the Aymara minority. We suggest that researchers in this field pay more attention to the communities’ internal diversity and its relations with the copper industry to understand how the water crisis is detached from its biophysical conceptions to be socioculturally constructed. HIGHLIGHTS The water crisis in the Atacama Desert is not only related to its natural conditions of biophysical scarcity.; An investigative approach focused on the sociocultural dimension could better show the everyday interactions of current water problems.; The interweaving of sociocultural practices and discourses with the conditions of the environment are key cornerstones to understanding how the water crisis is constructed.; The hyper-arid conditions of the desert and the scarce information on indicators hide the environmental damage that occurs in it.;

La irrupción de Pablo Iglesias supuso una revolución en la concepción bipartidista española. Desde el primer momento, el líder de Podemos se ha caracterizado por sus frecuentes presencias en las tertulias políticas y su intensa actividad en redes sociales. Consciente de su importancia, Iglesias ha presentado un discurso basado en argumentos que apelan, principalmente, al desafecto de la ciudadanía con sus políticos. El éxito fue tal que la formación obtuvo cinco eurodiputados en las europeas de 2014 tras cinco meses de existencia. No obstante, los partidos tradicionales (PP y PSOE), también conocidos como “la casta” por Iglesias, han calificado su discurso como populista y radical para obtener votantes entre un electorado presente en manifestaciones y mareas. Además, sus adversarios tratan de vincular a Podemos y Pablo Iglesias con los gobiernos “poco democráticos” de Venezuela o Cuba tras manifestar su aprobación con algunas políticas practicadas en tales naciones. Este estudio analiza el cambio en el discurso de Pablo Iglesias en Twitter a través del análisis crítico del discurso entre 2015 y 2019, pasando de un marcado populismo inicial a un enfoque conciliador en la segunda etapa.

The 2022 presidential election in Brazil involved two radically different candidates but with broad similarities in their populist discourse and communication strategies. The electoral campaign and the results polarized the country between the supporters of the outgoing president, Jair Bolsonaro, and the incoming one, Lula da Silva. This article analyzes the two television debates that took place in the second round of the presidential election in October. The interventions of the candidates have been studied using the methodology of critical discourse analysis applied by Hawkins (2010). The goal is to discover the degree of populism present in the candidates’ discourse in the two debates studied. The results show evidence of the highly populist nature of the discourse of the two leaders in both television events. This characteristic, as well as other important aspects of the campaigns and the narrow margin of Lula’s eventual victory, may explain the level of polarization evident in the country. It may also be the reason behind the rejection of the election results by the followers of Bolsonaro and their protest against the change in president.

En base a la investigación Biodiversidad, economía y empleo en España. Análisis y perspectivas de futuro (Oteros et al, 2022), nos centramos en las dimensiones de cambio de modelo productivo y, especialmente, en las ocupaciones y en el empleo, respetuosas con la biodiversidad. El objetivo consiste en: a) Examinar la inversión, gasto y tipo de actuación de la economía española en relación con el empleo y la biodiversidad entre 2011 y 2019;b) proyectar el empleo, bajo hipótesis de cambio hacia un modelo productivo basado en un metabolismo sociedad-naturaleza compatible respetuoso con la biodiversidad, proyectando para el periodo 2019-2028, según diferentes escenarios, de transición suave o intensa, en la estructura de ocupaciones; c) sugerir potenciales líneas de transformación necesarias -reconversiones de actividades y cambios en el tiempo de trabajo- para posibilitar una transición ecológica socialmente justa cuyas condiciones puedan prevenir los peligros que acechan a la biodiversidad en España.

Abstract The Atlantic Forest is known for its richness and diversity of species. Nonetheless, the diversity of millipedes in the biome is still poorly known. In this work, the distribution and the faunal composition of millipedes of the family Spirostreptidae Brandt, 1833 (order Spirostreptida) from the Atlantic Forest are provided. A total of 159 occurrence points were compiled, and 59 species in 17 genera were listed. GymnostreptusBrölemann, 1902 was recovered as the richest genus in the Atlantic Forest with 14 species and one subspecies. The species Plusioporus setiger (Brölemann, 1902) presented the highest number of records, with 22 occurrence points in at least 20 municipalities. A total of 35 species were recorded from only one municipality. Considering all the threats on the biome, this paper is important for our understanding of the Brazilian millipede fauna and can be useful to determine places that require valuations for collecting efforts and conservation policies.

The internet and digital technology have become an important resource for patients with cancer. Mobile health strategies permit patients and clinicians to interact via different tools to enrich the supplements to routine hospital visits or out-patient attendance. In this work, we have reviewed different mobile health platforms to support lung cancer patients in different areas: pre-surgery; post-surgery and on systemic treatment. We have also reviewed different digital tools used by long-term lung cancer survivors as well as the impact of these tools on the quality of life, and we tried to analyse according to literature the potential efficiency of these platforms in health system administration.

Designing a new astronomical instrument typically challenges the available cameras on the market. In many cases, no camera can fulfill the requirements of the instrument in terms of photon budget, speed, and even interfaces with the rest of the instrument. In this situation, the only options are to either downgrade the performance of the instrument or design new cameras from scratch, provided it is possible to identify a compliant detector. The latter is the case of the SPGCams, the cameras developed to be used with the Tunable Magnetograph (TuMag) and the Sunrise Chromospheric Infrared spectroPolarimeter (SCIP) for the Sunrise iii mission. SPGCams have been designed, developed, and built entirely in-house by the Solar Physics Group (SPG) at the Instituto de Astrofísica de Andalucía (IAA-CSIC). We report here on the scientific rationale and system engineering requirements set by the two instruments that drove the development, as well as on the technical details and trade-offs used to fulfill the specifications. The cameras were fully verified before the flight, and results from the assembly and verification campaign are presented as well. SPGCams share the design, although some parametric features differentiate the visible cameras (for TuMag) and the IR ones (for SCIP). Even though they were specifically developed for the Sunrise iii mission, the robust and careful design makes them suitable for different applications in other astronomical instruments.

BackgroundThe pan-European VACCELERATE network aims to implement the first transnational harmonized and sustainable vaccine trial Volunteer Registry, being a single entry point for potential volunteers of large-scale vaccine trials across Europe. This work exhibits a set of harmonized vaccine trial–related educational and promotional tools for the general public, designed and disseminated by the pan-European VACCELERATE network. ObjectiveThis study primarily aimed to design and develop a standard toolkit to increase positive attitudes and access to trustworthy information for better access and increased recruitment to vaccine trials for the public. More specifically, the produced tools are focused on inclusiveness and equity, and are targeting different population groups, including underserved ones, as potential volunteers for the VACCELERATE Volunteer Registry (older individuals, migrants, children, and adolescents). The promotional and educational material is aligned with the main objectives of the Volunteer Registry to increase public literacy and awareness regarding vaccine-related clinical research or trials and trial participation, including informed consent and legal issues, side effects, and frequently asked questions regarding vaccine trial design. MethodsTools were developed per the aims and principles of the VACCELERATE project, focusing on trial inclusiveness and equity, and are adjusted to local country-wise requirements to improve public health communication. The produced tools are selected based on the cognitive theory, inclusiveness, and equity of differently aged and underrepresented groups, and standardized material from several official trustworthy sources (eg, COVID-19 Vaccines Global Access; the European Centre for Disease Prevention and Control; the European Patients’ Academy on Therapeutic Innovation; Gavi, the Vaccine Alliance; and the World Health Organization). A team of multidisciplinary specialists (infectious diseases, vaccine research, medicine, and education) edited and reviewed the subtitles and scripts of the educational videos, extended brochures, interactive cards, and puzzles. Graphic designers selected the color palette, audio settings, and dubbing for the video story-tales and implemented QR codes. ResultsThis study presents the first set of harmonized promotional and educational materials and tools (ie, educational cards, educational and promotional videos, extended brochures, flyers, posters, and puzzles) for vaccine clinical research (eg, COVID-19 vaccines). These tools inform the public about possible benefits and disadvantages of trial participation and build confidence among participants about the safety and efficacy of COVID-19 vaccines and the health care system. This material has been translated into several languages and is intended to be freely and easily accessible to facilitate dissemination among VACCELERATE network participant countries and the European and global scientific, industrial, and public community. ConclusionsThe produced material could help fill knowledge gaps of health care personnel, providing the appropriate future patient education for vaccine trials, and tackling vaccine hesitancy and parents’ concerns for potential participation of children in vaccine trials.

In order to provide a reassessment of the Neotropical genus Pseudonannolene Silvestri, 1895, a cladistic analysis, biogeographic analysis, and taxonomic review were conducted in the present work. For the cladistic approach, 91 morphological characters were scored for 53 terminals as the ingroup and 10 as the outgroup. Three synapomorphies support the monophyly of the genus: presence of a longitudinal suture on the promentum, penial bases partially fused, and the internal branch of the gonopods surrounding the telopodite; and two homoplastic transformations: the lateral lobe of the collum densely striated and setae present up to the apical portion of the prefemoral process on the first leg-pair of males. The genus Pseudonannolene is recovered as sister-group of Epinannolene Brölemann, 1903 (Pseudonannoleninae). A total of 226 occurrence points were recorded for Pseudonannolene, with the majority of records from the Chacoan subregion, composed by Araucaria Forest, Atlantic, and Parana Forest provinces. The biogeographical searches using the Geographically explicit Event Model recovered two biogeographic reconstructions (cost of 79 000), with the vicariance events occurring more frequently in the deep clades, whereas sympatry and points of sympatry occurred in more inclusive clades. The first reconstruction recovered four vicariances, 13 sympatries, 4 points of sympatry, and 21 founder events, and the second reconstruction recovered four vicariances, 12–13 sympatries, 4–5 points of sympatry, and 21 founder events. The genus Pseudonannolene comprises 56 species, including 8 new species herein described: P. alata sp. nov., P. aurea sp. nov., P. bucculenta sp. nov., P. curvata sp. nov., P. granulata sp. nov., P. insularis sp. nov., P. morettii sp. nov., and P. nicolau sp. nov.; P. brevis Silvestri, 1902 and P. rugosetta Silvestri, 1897 are regarded as species inquirendae; a neotype of P. alegrensis Silvestri, 1897 is here proposed with male described for the first time. The following taxa are synonymized: P. canastra Gallo & Bichuette, 2020 and P. saguassu Iniesta & Ferreira, 2013 with P. ambuatinga Iniesta & Ferreira, 2013; P. marconii Iniesta & Ferreira, 2013 with P. longicornis (Porat, 1888); P. chaimowiczi Fontanetti, 1996, P. gogo Iniesta & Ferreira, 2013, P. rosineii Iniesta & Ferreira, 2014, P. taboa Iniesta & Ferreira, 2014, and P. longissima Iniesta & Ferreira, 2014 with P. microzoporus Mauriès, 1987; P. tricolor gracilis Brölemann, 1902 and P. tricolor rugosus Schubart, 1945 with P. tricolor Brölemann, 1902; P. auguralis Silvestri, 1902 with P. rocana Silvestri, 1902; and P. abbreviata Silvestri, 1902 with P. typica Silvestri, 1895. P. inops Brölemann, 1929 is proposed here as new status from P. bovei inops. A dichotomous identification key is presented to facilitate the species identification.