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Case report: Chromosomal breakage syndromes are characterized by cancer predisposition. Here we present a 27-month-old female with Fanconi Aplastic Anemia diagnosed with 4 tumors. Imaging showed brain mass causing the shift, liver mass and left kidney mass. She had diagnosed with high grade intracranial tm, wilms tm and hepatocellular ca. Because of refractory pancitopeni, she underwent HSCT. After 2months she developed intracranial embryonal tumor. The patient died with progression. Genetic tests revealed no mutation.

Case report: Primary lymphoma of bone (PLB) is a rare malignant condition with lymphocytic infiltration of the bone; it accounts for 2–3% of all primary bone tumours in adults and children .Here we report a little girl with isolated PLB of B cell lineage focussing on diagnosis, evaluation and treatment strategy. Our case can help to get acquaintance with PBL,it should be taken into consideration as a different diagnosis for osteolytic lesions of bone.

Case report: Cholestasis secondary to neoplasm is rare in children. It is also rare in Burkitt lymphoma and may be cause to treatment delay. We report 3 cases diagnosed with Burkitt lymphoma with cholestasis. All patients had jaundice and high direct biluribin levels. They were given LMB chemotherapy protocol. After COP chemotherapy, cholestasis disapperead rapidly in all patients. In conclusion, cholestasis at initial resolves rapidly with chemotherapy despite high liver function tests in Burkitt lymphoma.

Objective: Osteosarcoma and Ewing sarcoma are the most common bone sarcomas of the childhood. Kerbs von de Lungren 6 (KL-6) is a glycoprotein that is expressed on type 2 pneumocytes and bronchial epithelium. Serum KL-6 level can increase in many interstitial pulmonary diseas and lung cancers. Aim of the study is to evaluate the predictive value of serum KL-6 level on malign potential of pulmonary nodules in pediatric patients with bone sarcoma with pulmonary metastasis or with vague pulmonary nodules. Methodology: Blood samples were taken from patients with diagnosis of Ewing sarcoma or osteosarcoma at the time of diagnosis or first relapses. Control group was selected from 42 voluntary children without any chronic or acute diseases associated with lung. Serum of the blood samples were separated and frozen at -70 C˚ and KL-6 level was measured via ELISA method. Thorax computed tomography (CT) images of the patients were analyzed to interpret about pulmonary metastasis. Results: Total 47 patients were included in the study, 19 of the patients were with Ewing sarcoma and 28 with osteosarcoma.Thorax CT revealed pulmonary metastasis in 9 of the patients at first evaluation. KL-6 level of the these patients with pulmonary metastasis was greater than without metastasis (p;0.05) and control group (p;0.019). Patients with pulmonary nodule at any time had significantly higher serum KL-6 level at first evaluation than without metastasis (p; 0.04) and control group (p;0.017). Conclusion: In our study we found serum KL-6 level higher in patients with pulmonary nodules that relevant with pulmonary sarcoma metastasis than patients without metastasis and healthy control group. Our study also revealed that patients that had pulmonary metastasis during their follow-up also had higher KL-6 level at diagnosis. These results should be proven with more number of patients. Measuring KL-6 level may be used as a marker for early diagnosis of pulmonary sarcoma metastasis.

Case report: Ewing's sarcoma (ES) is the 2nd primary bone tumor of childhood, mostly located in the lower extremities. The incidence of primary cranial ES is

Case report: Burkitt lymphoma (BL) is an aggressive form of B-cell non-Hodgkin lymphoma. It may present with a variety of symptoms leading to possible misdiagnosis and delay in treatment. BL is fatal if left untreated, and early diagnosis and treatment can improve prognosis. In this case report, a 3.5-year-old male patient with no known disease had left eyelid swelling and hematuria, and orbital magnetic resonance imaging performed after his admission showed contrast enhancement in the bulbus oculi, and increased uptake in both kidneys (suvmax:9.5) in positron emission tomography. The patient's bone marrow aspiration was normal. There was no involvement in the evaluation of the central nervous system. As a result of kidney biopsy, he was diagnosed with high-grade B-cell lymphoproliferative disease (Ki-67 95-100%, diffuse positivity with CD79a and EBV). Burkitt lymphoma. The treatment of the patient was started in the NHL-BFM 2012 R4 arm. At the end of the treatment, the ocular findings regressed. Burkitt lymphoma may present with different clinical presentations. If appropriate and rapid imaging techniques are used, positive results on survival can be obtained. Our patient is being followed up alive and well.