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455 results on '"Imhof, Saskia M."'

101. Histopathologic features of retinoblastoma and its relation with in vitro drug resistance measured by means of the MTT assay

Author

Schouten-van Meeteren, antoinette Y.N., der Valk, Paul van, der Linden, Hans C.van, Moll, Annette C., Imhof, Saskia M., Huismans, Dieuwke R., Loonen, Anne H., and Veerman, Anjo J.P.

Subjects
Retinoblastoma -- Drug therapy, Drug resistance -- Physiological aspects, Calcification -- Physiological aspects, Histology, Pathological -- Analysis, Health
Published
2001

104. Reply

Author

Risseeuw, Sara, primary, Ossewaarde-van Norel, Jeannette, additional, Klaver, Caroline C. W., additional, Colijn, Johanna M., additional, Imhof, Saskia M., additional, and van Leeuwen, Redmer, additional

Published
2019
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106. Health-related quality of life of child and adolescent retinoblastoma survivors in the Netherlands

Author

Bezemer Pieter D, Schouten-van Meeteren Antoinette YN, Moll Annette C, Huisman Jaap, van Dijk Jennifer, Ringens Peter J, Cohen-Kettenis Peggy T, and Imhof Saskia M

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Background To assess health-related quality of life (HRQoL) in children (8–11 years) and adolescents (12–18 years) who survived retinoblastoma (RB), by means of the KIDSCREEN self-report questionnaire and the proxy-report version. Methods This population-based cross-sectional study (participation rate 70%) involved 65 RB survivors (8–18 years) and their parents. Child/adolescents' and parents' perception of their youth's HRQoL was assessed using the KIDSCREEN, and the results were compared with Dutch reference data. Relations with gender, age, marital status of the parents, and visual acuity were analyzed. Results RB survivors reported better HRQoL than did the Dutch reference group on the dimensions "moods and emotions" and "autonomy". Increased ratings of HRQoL in RB survivors were mainly seen in perceptions of the younger children and adolescent girls. RB survivors with normal visual acuity scored higher on "physical well-being" than visually impaired survivors. Age was negatively associated with the dimensions "psychological well-being", "self-perception" (according to the child and parent reports) and "parent relations and home life" (according to the child). "Self-perception" was also negatively associated with visual acuity (according to the child). Only parents of young boys surviving RB reported lower on "autonomy" than the reference group, and parents of low visual acuity and blind RB survivors reported higher on "autonomy" than parents of visually unimpaired survivors. Survivors' perceptions and parents' perceptions correlated poorly on all HRQoL dimensions. Conclusion RB survivors reported a very good HRQoL compared with the Dutch reference group. The perceptions related to HRQoL differ substantially between parents and their children, i.e. parents judge the HRQoL of their child to be relatively poorer. Although the results are reassuring, additional factors of HRQoL that may have more specific relevance, such as psychological factors or coping skills, should be explored.

Published
2007
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107. Quality of life of adult retinoblastoma survivors in the Netherlands

Author

Cohen-Kettenis Peggy T, Ringens Peter J, Moll Annette C, Imhof Saskia M, van Dijk Jennifer, Rijmen Frank, and Huisman Jaap

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Background To assess the quality of life (QoL) and predictors thereof in Dutch adult hereditary and non-hereditary retinoblastoma (RB) survivors. Methods In this population-based cross-sectional study, a generic QoL questionnaire (SF-36) and a disease-specific interview were administered to 87 adult RB survivors aged 18 to 35 years. Their QoL data were compared with those of a Dutch healthy reference group. Among the RB hereditary/non-hereditary survivors, the QoL was compared and predictors for QoL were identified by linear multiple regression analyses. Results As a group, RB survivors scored significantly lower than the reference group on the SF-36 subscale 'mental health' (t = -27, df = 86, p < 0.01). Hereditary RB survivors scored lower on the subscale 'general health' (t = 2.6, df = 85, p < 0.01) than non-hereditary RB survivors. Having experienced bullying, as a child was a predictor for the SF-36 subscales: 'physical functioning' (p < 0.05), 'role functioning physical' (p < 0.01), 'role functioning emotional' (p < 0.05) and 'social functioning' (p < 0.01). Having experienced bullying (p < 0.01), but also subjective experience of impairment related to RB (p < 0.05), was predictors for 'general health'. Subjective experience of impairment was a predictor for 'vitality' (p < 0.01) and 'bodily pain' (p < 0.01). Conclusion In this exploratory study, it appears that the group of adult RB survivors experience a relatively good overall but slightly decreased QoL compared with the reference group. However, they report more problems with regard to their mental health (anxiety, feelings of depression, and loss of control). Hereditary RB survivors differ significantly from non-hereditary RB survivors only in 'general health'. Bullying in childhood and subjective experience of impairment are the main predictors of a worse QoL. In order to prevent worsening of QoL, or perhaps to improve it, clinicians should make an inventory of these issues at an early stage. We recommend further research to assess the specific psychological factors that may lead to mental health problems in this population.

Published
2007
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108. High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis

Author

Verhagen, Fleurieke H., Hiddingh, Sanne, Rijken, Rianne, Pandit, Aridaman, Leijten, Emmerik, Olde Nordkamp, Michel, Ten Dam-van Loon, Ninette H., Nierkens, Stefan, Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., Kuiper, Jonas J.W., Verhagen, Fleurieke H., Hiddingh, Sanne, Rijken, Rianne, Pandit, Aridaman, Leijten, Emmerik, Olde Nordkamp, Michel, Ten Dam-van Loon, Ninette H., Nierkens, Stefan, Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., and Kuiper, Jonas J.W.

Published
2018

110. A disease-associated microRNA cluster links inflammatory pathways and an altered composition of leukocyte subsets to noninfectious uveitis

Author

Verhagen, Fleurieke H., Bekker, Cornelis P.J., Rossato, Marzia, Hiddingh, Sanne, de Vries, Lieuwe, Devaprasad, Abhinandan, Pandit, Aridaman, Ossewaarde-van Nore, Jeannette, ten Dam, Ninette, Moret-Pot, Maartje C.A., Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., Kuiper, Jonas J.W., Verhagen, Fleurieke H., Bekker, Cornelis P.J., Rossato, Marzia, Hiddingh, Sanne, de Vries, Lieuwe, Devaprasad, Abhinandan, Pandit, Aridaman, Ossewaarde-van Nore, Jeannette, ten Dam, Ninette, Moret-Pot, Maartje C.A., Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., and Kuiper, Jonas J.W.

Published
2018

111. Prevalence and characteristics of ocular pain in non-infectious uveitis: A quality of life study

Author

Oogheelkunde Onderzoek, Infection & Immunity, Zorgeenheid Oogheelkunde Zorg, MS Oogheelkunde, Verhagen, Fleurieke H, Wijnhoven, Ralph, Ossewaarde-van Norel, Jeannette, Ten Dam-van Loon, Ninette H, Kuiper, Jonas J W, Imhof, Saskia M, de Boer, Joke H, Oogheelkunde Onderzoek, Infection & Immunity, Zorgeenheid Oogheelkunde Zorg, MS Oogheelkunde, Verhagen, Fleurieke H, Wijnhoven, Ralph, Ossewaarde-van Norel, Jeannette, Ten Dam-van Loon, Ninette H, Kuiper, Jonas J W, Imhof, Saskia M, and de Boer, Joke H

Published
2018

112. High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis

Author

MS Oogheelkunde, Infection & Immunity, Translationele immunologie, CDL Patiëntenzorg MI, Other research (not in main researchprogram), Verhagen, Fleurieke H., Hiddingh, Sanne, Rijken, Rianne, Pandit, Aridaman, Leijten, Emmerik, Olde Nordkamp, Michel, Ten Dam-van Loon, Ninette H., Nierkens, Stefan, Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., Kuiper, Jonas J.W., MS Oogheelkunde, Infection & Immunity, Translationele immunologie, CDL Patiëntenzorg MI, Other research (not in main researchprogram), Verhagen, Fleurieke H., Hiddingh, Sanne, Rijken, Rianne, Pandit, Aridaman, Leijten, Emmerik, Olde Nordkamp, Michel, Ten Dam-van Loon, Ninette H., Nierkens, Stefan, Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., and Kuiper, Jonas J.W.

Published
2018

113. A disease-associated microRNA cluster links inflammatory pathways and an altered composition of leukocyte subsets to noninfectious uveitis

Author

Planning en Opnamebureau, Infection & Immunity, Lab Reumatologie/Klinische Immunologie, Translationele immunologie, MS Oogheelkunde, Other research (not in main researchprogram), Verhagen, Fleurieke H., Bekker, Cornelis P.J., Rossato, Marzia, Hiddingh, Sanne, de Vries, Lieuwe, Devaprasad, Abhinandan, Pandit, Aridaman, Ossewaarde-van Nore, Jeannette, ten Dam, Ninette, Moret-Pot, Maartje C.A., Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., Kuiper, Jonas J.W., Planning en Opnamebureau, Infection & Immunity, Lab Reumatologie/Klinische Immunologie, Translationele immunologie, MS Oogheelkunde, Other research (not in main researchprogram), Verhagen, Fleurieke H., Bekker, Cornelis P.J., Rossato, Marzia, Hiddingh, Sanne, de Vries, Lieuwe, Devaprasad, Abhinandan, Pandit, Aridaman, Ossewaarde-van Nore, Jeannette, ten Dam, Ninette, Moret-Pot, Maartje C.A., Imhof, Saskia M., de Boer, Joke H., Radstake, Timothy R.D.J., and Kuiper, Jonas J.W.

Published
2018

114. Etidronate for Prevention of Ectopic Mineralization in Patients With Pseudoxanthoma Elasticum

Author

Interne Geneeskunde Vasculaire, Circulatory Health, Researchgr. Systems Radiology, Infection & Immunity, Researchgr. Nucleaire Geneeskunde, Cancer, Zorglijn Kind, Orbita en Neuro, MS Geriatrie, Researchgr. Cardiovasculaire Radiologie, MS Radiologie, Brain, MS Interne Geneeskunde, Kranenburg, Guido, de Jong, Pim A., Bartstra, Jonas W., Lagerweij, Suzanne J., Lam, Marnix G., Ossewaarde-van Norel, Jeannette, Risseeuw, Sara, van Leeuwen, Redmer, Imhof, Saskia M., Verhaar, Harald J., de Vries, Job J., Slart, Riemer H.J.A., Luurtsema, Gert, den Harder, Annemarie M., Visseren, Frank L.J., Mali, Willem P., Spiering, Wilko, Interne Geneeskunde Vasculaire, Circulatory Health, Researchgr. Systems Radiology, Infection & Immunity, Researchgr. Nucleaire Geneeskunde, Cancer, Zorglijn Kind, Orbita en Neuro, MS Geriatrie, Researchgr. Cardiovasculaire Radiologie, MS Radiologie, Brain, MS Interne Geneeskunde, Kranenburg, Guido, de Jong, Pim A., Bartstra, Jonas W., Lagerweij, Suzanne J., Lam, Marnix G., Ossewaarde-van Norel, Jeannette, Risseeuw, Sara, van Leeuwen, Redmer, Imhof, Saskia M., Verhaar, Harald J., de Vries, Job J., Slart, Riemer H.J.A., Luurtsema, Gert, den Harder, Annemarie M., Visseren, Frank L.J., Mali, Willem P., and Spiering, Wilko

Published
2018

116. High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis

Author

Verhagen, Fleurieke H., primary, Hiddingh, Sanne, additional, Rijken, Rianne, additional, Pandit, Aridaman, additional, Leijten, Emmerik, additional, Olde Nordkamp, Michel, additional, ten Dam-van Loon, Ninette H., additional, Nierkens, Stefan, additional, Imhof, Saskia M., additional, de Boer, Joke H., additional, Radstake, Timothy R. D. J., additional, and Kuiper, Jonas J. W., additional

Published
2018
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117. A Disease-Associated MicroRNA Cluster Links Inflammatory Pathways and an Altered Composition of Leukocyte Subsets to Noninfectious Uveitis

Author

Verhagen, Fleurieke H., primary, Bekker, Cornelis P. J., additional, Rossato, Marzia, additional, Hiddingh, Sanne, additional, de Vries, Lieuwe, additional, Devaprasad, Abhinandan, additional, Pandit, Aridaman, additional, Ossewaarde-van Norel, Jeannette, additional, ten Dam, Ninette, additional, Moret-Pot, Maartje C. A., additional, Imhof, Saskia M., additional, de Boer, Joke H., additional, Radstake, Timothy R. D. J., additional, and Kuiper, Jonas J. W., additional

Published
2018
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122. Cost-Effectiveness Analysis of Corneal Collagen Crosslinking for Progressive Keratoconus

Author

Oogheelkunde Onderzoek, Other research (not in main researchprogram), HEE, Circulatory Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, MS Oogheelkunde, Infection & Immunity, Godefrooij, Daniel A, Mangen, Marie-Josee J, Chan, Elsie, O'Brart, David P S, Imhof, Saskia M, de Wit, G Ardine, Wisse, Robert P L, Oogheelkunde Onderzoek, Other research (not in main researchprogram), HEE, Circulatory Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, MS Oogheelkunde, Infection & Immunity, Godefrooij, Daniel A, Mangen, Marie-Josee J, Chan, Elsie, O'Brart, David P S, Imhof, Saskia M, de Wit, G Ardine, and Wisse, Robert P L

Published
2017

123. Age-specific incidence and prevalence of keratoconus: a nationwide registration study

Author

Oogheelkunde Onderzoek, Other research (not in main researchprogram), HEE, Circulatory Health, JC onderzoeksprogramma Methodologie, Cardiovasculaire Epi Team 4, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Oogheelkunde, Infection & Immunity, Godefrooij, Daniel A, de Wit, G Ardine, Uiterwaal, Cuno S, Imhof, Saskia M, Wisse, Robert P L, Oogheelkunde Onderzoek, Other research (not in main researchprogram), HEE, Circulatory Health, JC onderzoeksprogramma Methodologie, Cardiovasculaire Epi Team 4, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Oogheelkunde, Infection & Immunity, Godefrooij, Daniel A, de Wit, G Ardine, Uiterwaal, Cuno S, Imhof, Saskia M, and Wisse, Robert P L

Published
2017

124. Ocular fluid analysis in children reveals interleukin-29/interferon-λ1 as a biomarker for juvenile idiopathic arthritis associated uveitis

Author

Haasnoot, Arenda J W, Kuiper, Jonas J W, Hiddingh, Sanne, Schellekens, Peter A W J F, de Jager, W, Imhof, Saskia M, Radstake, Timothy R D J, and de Boer, Joke H

Subjects
musculoskeletal diseases, genetic structures, Journal Article, eye diseases
Abstract

OBJECTIVE: Childhood uveitis is a visual-threatening inflammatory eye disease commonly attributed to juvenile idiopathic arthritis (JIA). The pathogenesis is poorly understood, which makes clinical management challenging. We analyzed soluble mediators in ocular fluid (aqueous humor; AqH) and serum of children with JIA associated uveitis (JIA-U) and common childhood uveitis to identify potential biomarkers and investigate the ocular micro-environment of this sight-threatening eye disease. METHODS: AqH (n=73) and paired serum (n=66) samples were analyzed for 51 soluble inflammatory mediators by multiplex immunoassay. Twenty-one children with JIA-U were compared with 15 with chronic anterior uveitis without arthritis (CAU), 29 with non-infectious idiopathic uveitis (IU), and 8 non-inflammatory controls. For visualization of the joint effect of multiple mediators, we exploited the radial coordinate visualization method (Radviz(TM) ). Also, optimal biomarker level cutoffs were determined. RESULTS: The levels of interleukin-29/interferon-λ1 (IL-29/IFN-λ1) were decreased (P

Published
2016

127. Reply to: Transepithelial Versus Epithelium-off Corneal Cross-Linking for the Treatment of Progressive Keratoconus: A Randomized Controlled Trial

Author

Soeters, Nienke, Wisse, Robert, Godefrooij, Daniël A., Imhof, Saskia M., and Tahzib, Nayyirih G.

Subjects
Ophthalmology, Letter, Comment
Abstract

WE WOULD LIKE TO THANK THE AUTHORS FOR THEIR comment on our recently published randomized transepi- thelial corneal cross-linking (CXL) study, 1 and for their suggestions for failure of the transepithelial CXL tech- nique

Published
2015

134. CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

Author

van Diemen, Ferdy R., Kruse, Elisabeth M., Hooykaas, Marjolein J G, Bruggeling, Carlijn E., Schürch, Anita C., van Ham, Petra M., Imhof, Saskia M., Nijhuis, Monique, Wiertz, Emmanuel J H J, Lebbink, Robert Jan, van Diemen, Ferdy R., Kruse, Elisabeth M., Hooykaas, Marjolein J G, Bruggeling, Carlijn E., Schürch, Anita C., van Ham, Petra M., Imhof, Saskia M., Nijhuis, Monique, Wiertz, Emmanuel J H J, and Lebbink, Robert Jan

Published
2016

138. Visual outcome in Sturge-Weber syndrome: A systematic review and Dutch multicentre cohort

Author

Brain, MS Oogheelkunde, Infection & Immunity, ZL Kinder Ner en Nec Medisch, Koenraads, Yvonne, van Egmond-Ebbeling, Michelle B., de Boer, Joke H., Imhof, Saskia M., Braun, Kees P. J., Porro, Giorgio L., Brain, MS Oogheelkunde, Infection & Immunity, ZL Kinder Ner en Nec Medisch, Koenraads, Yvonne, van Egmond-Ebbeling, Michelle B., de Boer, Joke H., Imhof, Saskia M., Braun, Kees P. J., and Porro, Giorgio L.

Published
2016

139. Higher-order aberrations 1 year after corneal collagen crosslinking for keratoconus and their independent effect on visual acuity

Author

MS Oogheelkunde, Oogheelkunde Onderzoek, Zorglijn Voorsegment en Algemeen, Infection & Immunity, Wisse, Robert P L, Gadiot, Stijn, Soeters, Nienke, Godefrooij, Daniel A, Imhof, Saskia M, van der Lelij, Gonnie, MS Oogheelkunde, Oogheelkunde Onderzoek, Zorglijn Voorsegment en Algemeen, Infection & Immunity, Wisse, Robert P L, Gadiot, Stijn, Soeters, Nienke, Godefrooij, Daniel A, Imhof, Saskia M, and van der Lelij, Gonnie

Published
2016

140. CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

Author

MMB Research line 3a, Infection & Immunity, MMB, MS Oogheelkunde, van Diemen, Ferdy R., Kruse, Elisabeth M., Hooykaas, Marjolein J G, Bruggeling, Carlijn E., Schürch, Anita C., van Ham, Petra M., Imhof, Saskia M., Nijhuis, Monique, Wiertz, Emmanuel J H J, Lebbink, Robert Jan, MMB Research line 3a, Infection & Immunity, MMB, MS Oogheelkunde, van Diemen, Ferdy R., Kruse, Elisabeth M., Hooykaas, Marjolein J G, Bruggeling, Carlijn E., Schürch, Anita C., van Ham, Petra M., Imhof, Saskia M., Nijhuis, Monique, Wiertz, Emmanuel J H J, and Lebbink, Robert Jan

Published
2016

142. Objective and subjective evaluation of the performance of medical contact lenses fitted using a contact lens selection algorithm

Author

Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Oogheelkunde Onderzoek, Zorglijn Voorsegment en Algemeen, Infection & Immunity, Visser, Esther-Simone, Wisse, Robert P L, Soeters, Nienke, Imhof, Saskia M, van der Lelij, Allegonda, Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Oogheelkunde Onderzoek, Zorglijn Voorsegment en Algemeen, Infection & Immunity, Visser, Esther-Simone, Wisse, Robert P L, Soeters, Nienke, Imhof, Saskia M, and van der Lelij, Allegonda

Published
2016

143. Corneal Cross-Linking for Pediatric Keratoconus: Long-Term Results

Author

Oogheelkunde Onderzoek, Zorglijn Voorsegment en Algemeen, MS Oogheelkunde, Infection & Immunity, Godefrooij, Daniel A, Soeters, Nienke, Imhof, Saskia M, Wisse, Robert P L, Oogheelkunde Onderzoek, Zorglijn Voorsegment en Algemeen, MS Oogheelkunde, Infection & Immunity, Godefrooij, Daniel A, Soeters, Nienke, Imhof, Saskia M, and Wisse, Robert P L

Published
2016

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