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103. Cost-Effectiveness of long-term tolvaptan administration for chronic heart failure treatment in Japan.

Author

Nakao, Yasuhisa, Kawakami, Hiroshi, Saito, Makoto, Inoue, Katsuji, Ikeda, Shuntaro, and Yamaguchi, Osamu

Abstract

• Long-term tolvaptan (TLV) administration provided no clear benefit for all patients with chronic heart failure. • The TLV strategy may be a cost-effective therapeutic option in specific patients. • Patients receiving high-dose furosemide may benefit from the TLV strategy. Tolvaptan (TLV) is effective for acute heart failure (HF) with congestion, but its long-term administration in patients with chronic HF (CHF) remains controversial. Moreover, the cost-effectiveness of TLV for CHF treatment has not yet been investigated. Thus, we sought to validate the cost-effectiveness of TLV for CHF treatment in Japan. A Markov model was developed to compare total costs, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratio (ICER) between long-term TLV strategy and the standard strategy using furosemide for CHF. The target population included 75-year-old patients with CHF. The effectiveness of the TLV strategy for CHF treatment was determined based on a systematic review and meta-analysis. We used a 10-year horizon, with sensitivity analyses for significant variables and a scenario analysis for patients with CHF receiving high-dose furosemide (≥60 mg per day). In the base case analysis, the total cost of the long-term TLV strategy was higher than that of the standard strategy (¥3,243,779 vs. ¥1,179,964). The total QALYs of the long-term TLV strategy were lower than those of the standard strategy (4.52 vs 4.59). Thus, a standard TLV prescription for CHF treatment has no clinical or economic benefit. In the scenario analysis (i.e. in patients with CHF receiving high-dose furosemide), the long-term TLV strategy was more effective (total QALYs, 5.10 vs. 4.41) but more expensive (total costs, ¥3,540,558 vs. ¥1,272,208) than the standard strategy. The ICER of the TLV strategy against the standard strategy (¥3,289,579/QALY) was below the willingness-to-pay of ¥5,000,000, which suggests that the long-term TLV strategy is cost-effective relative to the standard strategy in patients with CHF receiving high-dose furosemide. Long-term TLV administration did not provide a clear benefit for all patients with CHF. However, this treatment strategy may be a cost-effective therapeutic option for patients who require high-dose furosemide. [Display omitted]. [ABSTRACT FROM AUTHOR]

Published
2022
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106. Impact of right ventricular contractile reserve during low‐load exercise on exercise intolerance in heart failure

Author

Kinoshita, Masaki, primary, Inoue, Katsuji, additional, Higashi, Haruhiko, additional, Akazawa, Yusuke, additional, Sasaki, Yasuhiro, additional, Fujii, Akira, additional, Uetani, Teruyoshi, additional, Inaba, Shinji, additional, Aono, Jun, additional, Nagai, Takayuki, additional, Nishimura, Kazuhisa, additional, Ikeda, Shuntaro, additional, and Yamaguchi, Osamu, additional

Published
2020
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108. Cost-Effectiveness of Obstructive Sleep Apnea Screening and Treatment Before Catheter Ablation for Symptomatic Atrial Fibrillation

Author

Kawakami, Hiroshi, primary, Saito, Makoto, additional, Kodera, Satoshi, additional, Fujii, Akira, additional, Nagai, Takayuki, additional, Uetani, Teruyoshi, additional, Tanno, Sakurako, additional, Oka, Yasunori, additional, Ikeda, Shuntaro, additional, Komuro, Issei, additional, Marwick, Thomas H., additional, and Yamaguchi, Osamu, additional

Published
2020
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109. Combined assessment of subtended myocardial volume and myocardial blood flow for diagnosis of obstructive coronary artery disease using cardiac computed tomography: A feasibility study

Author

Tanabe, Yuki, primary, Kido, Teruhito, additional, Kurata, Akira, additional, Uetani, Teruyoshi, additional, Kuwahara, Natsumi, additional, Morikawa, Tomoro, additional, Kawaguchi, Naoto, additional, Kido, Tomoyuki, additional, Nishimura, Kazuhisa, additional, Ikeda, Shuntaro, additional, Yamaguchi, Osamu, additional, and Mochizuki, Teruhito, additional

Published
2020
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110. Diagnostic accuracy of stress myocardial computed tomography perfusion imaging to detect myocardial ischemia: a comparison with coronary flow velocity reserve derived from transthoracic Doppler echocardiography

Author

Kono, Tamami, primary, Uetani, Teruyoshi, additional, Inoue, Katsuji, additional, Nagai, Takayuki, additional, Nishimura, Kazuhisa, additional, Suzuki, Jun, additional, Tanabe, Yuki, additional, Kido, Teruhito, additional, Kurata, Akira, additional, Mochizuki, Teruhito, additional, Ogimoto, Akiyoshi, additional, Okura, Takafumi, additional, Higaki, Jitsuo, additional, Yamaguchi, Osamu, additional, and Ikeda, Shuntaro, additional

Published
2020
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111. Semiquantitative assessment of the relative apical sparing pattern of longitudinal strain for cardiac amyloidosis identification

Author

Saito, Makoto, primary, Imai, Misaki, additional, Wake, Daisuke, additional, Higaki, Rieko, additional, Nakao, Yasuhisa, additional, Sumimoto, Takumi, additional, Yokomoto, Yuki, additional, Ogimoto, Akiyoshi, additional, Suzuki, Moeko, additional, Kawakami, Hideo, additional, Hiasa, Go, additional, Okayama, Hideki, additional, Inoue, Katsuji, additional, Ikeda, Shuntaro, additional, and Yamaguchi, Osamu, additional

Published
2020
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115. Clinical Therapy in Patients with Aborted Sudden Cardiac Death due to Coronary Spasm

Author

Sueda, Shozo, primary, Shinohara, Tetsuji, additional, Takahashi, Naohiko, additional, Shite, Junya, additional, Shoji, Toshihiro, additional, Akao, Masaharu, additional, Kijima, Yoshiyuki, additional, Masuyama, Tohru, additional, Miyaji, Tsuyoshi, additional, Yamamoto, Katsuhito, additional, Iwasaki, Yoshihiro, additional, Yoshida, Ritsu, additional, Nakamura, Shigeru, additional, Ogino, Yutaka, additional, Kimura, Kazuo, additional, Sasai, Masahiro, additional, Suzuki, Hiroshi, additional, Wakatsuki, Tetsuzo, additional, Asajima, Hiroshi, additional, Teragawa, Hiroki, additional, Ishikawa, Tetsunori, additional, Kitamura, Kazuo, additional, Oda, Tsuyoshi, additional, Nakayama, Takashi, additional, Kobayashi, Yoshio, additional, Sunada, Daiki, additional, Yamaki, Masaru, additional, Nishizaki, Fumie, additional, Tomita, Hirofumi, additional, Usuda, Kazuo, additional, Fujinaga, Hiroyuki, additional, Kuramitsu, Shoichi, additional, Ando, Kenji, additional, Kiyooka, Takahiko, additional, Kadota, Kazushige, additional, Ishii, Yoshinao, additional, Ohtani, Hayato, additional, Maekawa, Yuichiro, additional, Taguchi, Eiji, additional, Nakao, Koichi, additional, Kobayashi, Nobuaki, additional, Seino, Yoshihiko, additional, Nakagawa, Hitoshi, additional, Saito, Yoshihiko, additional, Komuro, Issei, additional, Sasaki, Yasuhiro, additional, Ikeda, Shuntaro, additional, Yamaguchi, Osamu, additional, Kakutani, Akiyoshi, additional, Imanaka, Takahiro, additional, Ishihara, Masaharu, additional, Ishii, Masanobu, additional, Kaikita, Koichi, additional, and Tsujita, Kenichi, additional

Published
2020
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118. Impact of chronic kidney disease on the diuretic response of tolvaptan in acute decompensated heart failure

Author

Ikeda, Shuntaro, Ohshima, Kiyotaka, Miyazaki, Shigehiro, Kadota, Hisaki, Shimizu, Hideaki, Ogimoto, Akiyoshi, and Hamada, Mareomi

Subjects
Heart Failure, Male, Dose-Response Relationship, Drug, Acute decompensated heart failure, Benzazepines, urologic and male genital diseases, Diuresis, Treatment Outcome, Original Research Articles, Chronic kidney disease, Tolvaptan, Acute Disease, Disease Progression, Humans, Female, Original Research Article, Diuretic response, Renal Insufficiency, Chronic, Antidiuretic Hormone Receptor Antagonists, Aged, Follow-Up Studies, Glomerular Filtration Rate, Retrospective Studies
Abstract

Aim This study investigated the relationship between the initial diuretic response to tolvaptan and clinical predictors for tolvaptan responders in patients with acute decompensated heart failure (ADHF). Methods and results Patients (153) with ADHF (clinical scenario 2 or 3 with signs of fluid retention) who were administered tolvaptan were enrolled. Tolvaptan (15 or 7.5 mg) was administered for at least 7 days to those patients in whom fluid retention was observed even after standard treatment. The maximum urine volume immediately after tolvaptan administration showed good correlations with the ejection fraction and estimated glomerular filtration rate that were independent predictors of the urine volume (UV) responders (≥1500 mL increase in urine volume). The diuretic response (in terms of maximum diuresis) diminished with advancing chronic kidney disease (CKD) stage and concomitant deterioration of the renal function. Furthermore, advanced CKD was a significant negative predictor for the body weight (BW) responders (2.0% decrease in the body weight within 1 week after starting tolvaptan). As compared with non‐CKD, the presence of advanced CKD predicts poor diuretic response for both UV and BW responders. Conclusions The diuretic response following tolvaptan administration gradually diminished with progressive deterioration of the CKD stage. Worsening renal function was not observed. Tolvaptan is effective in treating CS2 or CS3 ADHF patients who present fluid retention and congestion, suggesting its potential efficacy for fluid management in the ADHF patients with CKD without worsening the renal function.

Published
2017

119. Premature atrial contractions with multiple patterns of aberrant conduction followed by torsade de pointes in a patient with polymyalgia rheumatica: A case report.

Author

Koji Takahashi, Mina Yamashita, Tomoki Sakaue, Daijiro Enomoto, Shigeki Uemura, Takafumi Okura, Shuntaro Ikeda, Masafumi Takemoto, Yutaka Utsunomiya, Takashi Hyodo, Masayuki Ochi, Satoshi Higuchi, Takahashi, Koji, Yamashita, Mina, Sakaue, Tomoki, Enomoto, Daijiro, Uemura, Shigeki, Okura, Takafumi, Ikeda, Shuntaro, and Takemoto, Masafumi

Published
2021
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121. Coronary artery stenosis-related perfusion ratio using dynamic computed tomography myocardial perfusion imaging: a pilot for identification of hemodynamically significant coronary artery disease

Author

Kuwahara, Natsumi, primary, Tanabe, Yuki, additional, Kido, Teruhito, additional, Kurata, Akira, additional, Uetani, Teruyoshi, additional, Ochi, Hitomi, additional, Kawaguchi, Naoto, additional, Kido, Tomoyuki, additional, Ikeda, Shuntaro, additional, Yamaguchi, Osamu, additional, Asano, Migiwa, additional, and Mochizuki, Teruhito, additional

Published
2019
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123. On-Site Computed Tomography-Derived Fractional Flow Reserve Using a Machine-Learning Algorithm ― Clinical Effectiveness in a Retrospective Multicenter Cohort ―

Author

Kurata, Akira, primary, Fukuyama, Naoki, additional, Hirai, Kuniaki, additional, Kawaguchi, Naoto, additional, Tanabe, Yuki, additional, Okayama, Hideki, additional, Shigemi, Susumu, additional, Watanabe, Kouki, additional, Uetani, Teruyoshi, additional, Ikeda, Shuntaro, additional, Inaba, Shinji, additional, Kido, Teruhito, additional, Itoh, Toshihide, additional, and Mochizuki, Teruhito, additional

Published
2019
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128. Abstract 16924: Diagnostic Accuracy of Quantification Myocardial Perfusion Ratio Derived From Dynamic CT Perfusion Imaging for Detection of Functionally Significant Stenosis

Author

Uetani, Teruyoshi, primary, Kido, Teruhito, additional, Nakao, Yasuhisa, additional, Akazawa, Yusuke, additional, Kinoshita, Masaki, additional, Seike, Fumiyasu, additional, Sasaki, Yasuhiro, additional, Higashi, Haruhiko, additional, Fujii, Akira, additional, Aono, Jun, additional, Nagai, Takayuki, additional, Nishimura, Kazuhisa, additional, Inoue, Katsuji, additional, Ikeda, Shuntaro, additional, and Yamaguchi, Osamu, additional

Published
2018
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129. Relationships between immunoglobulin and fat-soluble vitamins in colostrum of Japanese Black multiparous cows

Author

Wang, Mengdong, Ikeda, Shuntaro, Yoshioka, Hidetugu, Nagase, Hiroshi, Kitamura, Shoko, Itoyama, Erina, Murakami, Hiroaki, Sugimoto, Miki, and Kume, Shinichi

Subjects
β-carotene, colostral IgG, food and beverages, Japanese Black cow, vitamin A, colostral IgA
Abstract

Data from 19 Japanese Black multiparous cows were collected to clarify the relationships among immunoglobulin (Ig) G, IgA, β-carotene, vitamin A and α-tocopherol contents in colostrum of cows in order to evaluate the role of fat-soluble vitamins on colostral IgG and IgA production. Mean colostral IgG was 141 mg/mL, ranging from 65 to 208 mg/mL, whereas mean colostral IgA was 8.7 mg/mL, ranging from 1.0 to 34.6 mg/mL. Colostral IgG increased with aging in multiparous cows. There were positive correlations between colostral IgG and colostral vitamin A or colostral α-tocopherol in cows, and the higher adjusted R(2) was obtained in the prediction model of colostral IgG from age and colostral vitamin A. Colostral vitamin A was positively correlated with colostral β-carotene or colostral α-tocopherol in cows, but there were no relationships between colostral IgA and colostral IgG or colostral fat-soluble vitamins. These results indicate that fat-soluble vitamin contents in colostrum of cows may change in similar patterns and high colostral vitamin A is related with high colostral IgG.

Published
2014

131. Effects of astaxanthin-enriched yeast on mucosal IgA induction in the jejunum and ileum of weanling mice

Author

Nagayama, Tatsuhiko, Sugimoto, Miki, Ikeda, Shuntaro, and Kume, Shinichi

Subjects
astaxanthin, weanling mice, digestive, oral, and skin physiology, ileum, jejunum, digestive system, IgA
Abstract

The present study was conducted to clarify the effects of astaxanthin-enriched yeast on the concentration of immunoglobulin A (IgA), the numbers of IgA antibody-secreting cells (ASC) and the messenger RNA (mRNA) expression of IgA C-region in the jejunum and ileum of weanling mice. Weanling mice were fed rodent feed or astaxanthin-enriched yeast-supplemented rodent feed for 7, 14 or 21 days. Supplemental astaxanthin-enriched yeast increased the numbers of IgA ASC in the jejunum and ileum after 7, 14 and 21 days of treatment. Supplemental astaxanthin-enriched yeast increased IgA concentrations in the jejunum after 21 days of treatment, but IgA concentrations in the ileum were not affected by the treatment. The mRNA expressions of IgA C-region in the jejunum after 14 and 21 days of treatment and the ileum after 14 days of treatment were enhanced by supplementation of astaxanthin-enriched yeast. These results indicate that supplementation of astaxanthin-enriched yeast is effective to enhance the numbers of IgA ASC in the jejunum and ileum and IgA concentrations in the ileum of weanling mice.

Published
2013

134. Biochemical and histological evidence of deteriorated bioprosthetic valve leaflets: the accumulation of fibrinogen and plasminogen

Author

Sakaue, Tomohisa, primary, Nakaoka, Hirotomo, additional, Shikata, Fumiaki, additional, Aono, Jun, additional, Kurata, Mie, additional, Uetani, Teruyoshi, additional, Hamaguchi, Mika, additional, Kojima, Ai, additional, Uchita, Shunji, additional, Yasugi, Takumi, additional, Higashi, Haruhiko, additional, Suzuki, Jun, additional, Ikeda, Shuntaro, additional, Higaki, Jitsuo, additional, Higashiyama, Shigeki, additional, and Izutani, Hironori, additional

Published
2018
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135. A Novel Truncating LMNA Mutation in Patients with Cardiac Conduction Disorders and Dilated Cardiomyopathy

Author

Kawakami, Hiroshi, primary, Ogimoto, Akiyoshi, additional, Tokunaga, Naohito, additional, Nishimura, Kazuhisa, additional, Kawakami, Hideo, additional, Higashi, Haruhiko, additional, Iio, Chiharuko, additional, Kono, Tamami, additional, Aono, Jun, additional, Uetani, Teruyoshi, additional, Nagai, Takayuki, additional, Inoue, Katsuji, additional, Suzuki, Jun, additional, Ikeda, Shuntaro, additional, Okura, Takafumi, additional, Ohyagi, Yasumasa, additional, Tabara, Yasuharu, additional, and Higaki, Jitsuo, additional

Published
2018
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136. Effects of supplemental β-carotene on colostral immunoglobulin and plasma β-carotene and immunoglobulin in Japanese Black cows

Author

Ishida, Maho, primary, Nishijima, Yoshitaka, additional, Ikeda, Shuntaro, additional, Yoshitani, Kenichi, additional, Obata, Atsutoshi, additional, Sugie, Yuji, additional, Aoki, Yoshikazu, additional, Yamaji, Taisuke, additional, Fujita, Masahiko, additional, Nakatsuji, Yoshinobu, additional, and Kume, Shinichi, additional

Published
2018
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138. Incremental value of left atrial active function measured by speckle tracking echocardiography in patients with hypertrophic cardiomyopathy

Author

Fujimoto, Kaori, primary, Inoue, Katsuji, additional, Saito, Makoto, additional, Higashi, Haruhiko, additional, Kono, Tamami, additional, Uetani, Teruyoshi, additional, Aono, Jun, additional, Nagai, Takayuki, additional, Nishimura, Kazuhisa, additional, Suzuki, Jun, additional, Okura, Takafumi, additional, Ikeda, Shuntaro, additional, Nakatani, Satoshi, additional, and Higaki, Jitsuo, additional

Published
2018
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140. Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor

Author

Higaki, Akinori, primary, Mogi, Masaki, additional, Iwanami, Jun, additional, Min, Li‐Juan, additional, Bai, Hui‐Yu, additional, Shan, Bao‐Shuai, additional, Kukida, Masayoshi, additional, Yamauchi, Toshifumi, additional, Tsukuda, Kana, additional, Kan‐no, Harumi, additional, Ikeda, Shuntaro, additional, Higaki, Jitsuo, additional, and Horiuchi, Masatsugu, additional

Published
2018
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141. Efficacy and safety of rivaroxaban in extreme elderly patients with atrial fibrillation: Analysis of the Shikoku Rivaroxaban Registry Trial (SRRT)

Author

Bando, Shigenobu, primary, Nishikado, Akiyoshi, additional, Hiura, Norikazu, additional, Ikeda, Shuntaro, additional, Kakutani, Akiyoshi, additional, Yamamoto, Katsuhito, additional, Kaname, Noriyoshi, additional, Fukatani, Masahiko, additional, Takagi, Yuichiro, additional, Yukiiri, Kazushi, additional, Fukuda, Yamato, additional, and Nakaya, Yutaka, additional

Published
2018
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142. Intravascular Ultrasound-Derived Virtual Fractional Flow Reserve for the Assessment of Myocardial Ischemia

Author

Seike, Fumiyasu, primary, Uetani, Teruyoshi, additional, Nishimura, Kazuhisa, additional, Kawakami, Hiroshi, additional, Higashi, Haruhiko, additional, Fujii, Akira, additional, Aono, Jun, additional, Nagai, Takayuki, additional, Inoue, Katsuji, additional, Suzuki, Jun, additional, Inaba, Shinji, additional, Okura, Takafumi, additional, Yasuda, Kazunori, additional, Higaki, Jitsuo, additional, and Ikeda, Shuntaro, additional

Published
2018
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143. Cardiovascular Outcomes in Patients with Previous Myocardial Infarction and Mild Diabetes Mellitus Following Treatment with Pioglitazone -Reports from the Japan Working Group for the Assessment Whether Pioglitazone Protects Dm Patients Against Re-Infarction (Ppar Study)-

Author

Asakura, Masanori, primary, Kim, Jiyoong, additional, Asanuma, Hiroshi, additional, Nakama, Yasuharu, additional, Tsukahara, Kengo, additional, Higashino, Yorihiko, additional, Ishikawa, Tetsuya, additional, Koba, Shinji, additional, Tsujimoto, Mitsuru, additional, Himeno, Hideo, additional, Maruyama, Yasuyuki, additional, Ookusa, Takanori, additional, Yoda, Shunichi, additional, Suzuki, Hiroshi, additional, Okubo, Shinji, additional, Shimizu, Makoto, additional, Hashimoto, Yuji, additional, Satake, Kazuo, additional, Fujino, Susumu, additional, Uzui, Hiroyasu, additional, Nagai, Yoshiyuki, additional, Kohno, Tohru, additional, Mizuno, Sumio, additional, Nakahama, Makoto, additional, Kanaya, Hounin, additional, Murohara, Toyoaki, additional, Fukui, Kazuki, additional, Takase, Hiroyuki, additional, Ohte, Nobuyuki, additional, Shiono, Takaaki, additional, Fukunami, Masatake, additional, Endo, Tsutomu, additional, Sawada, Reimin, additional, Fujii, Kenshi, additional, Takeuchi, Motoshi, additional, Ikeda, Shuntaro, additional, Mizuno, Koichi, additional, Uematsu, Masaaki, additional, Matsubara, Taku, additional, Yano, Shoji, additional, Takahashi, Jun, additional, Ueda, Kousei, additional, Kinoshita, Yoshihiko, additional, Tamita, Koichi, additional, Hayashi, Hideki, additional, Hamasaki, Toshimitsu, additional, and Kitakaze, Masafumi, additional

Published
2018
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145. Stent Thrombosis and Intrastent Thrombus Formation in Patients Undergoing Elective PCI: Results of an Angioscopic Substudy of the Randomized Trial PRASFIT-Elective (PRASugrel for Japanese PatIenTs with Coronary Artery Disease Undergoing Elective PCI)

Author

Ueno, Takafumi, primary, Mizuno, Kyoichi, additional, Hirayama, Atsushi, additional, Nishino, Masami, additional, Takano, Hitoshi, additional, Takayama, Tadateru, additional, Ueda, Yasunori, additional, Shinke, Toshiro, additional, Ikeda, Shuntaro, additional, Awata, Masaki, additional, Ishihara, Takayuki, additional, Saito, Shigeru, additional, Nakamura, Masato, additional, Abe, Kenji, additional, and Nanto, Shinsuke, additional

Published
2018
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146. Predicting_MWM_with_ANN v1

Author

Higaki, Akinori, primary, Mogi, Masaki, additional, Iwanami, Jun, additional, Min, Li-Juan, additional, Bai, Hui-Yu, additional, Shan, Bao-Shuai, additional, Kukida, Masayoshi, additional, Kan-no, Harumi, additional, Ikeda, Shuntaro, additional, Higaki, Jitsuo, additional, and Horiuchi, Masatsugu, additional

Published
2017
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147. Clinical significance of atrial high-rate episodes for thromboembolic events in Japanese population

Author

Kawakami, Hiroshi, primary, Nagai, Takayuki, additional, Saito, Makoto, additional, Inaba, Shinji, additional, Seike, Fumiyasu, additional, Nishimura, Kazuhisa, additional, Inoue, Katsuji, additional, Okura, Takafumi, additional, Sumimoto, Takumi, additional, Uemura, Shigeki, additional, Higaki, Jitsuo, additional, and Ikeda, Shuntaro, additional

Published
2017
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149. Estimation of myocardial flow reserve utilizing an ultrafast cardiac SPECT: Comparison with coronary angiography, fractional flow reserve, and the SYNTAX score

Author

Miyagawa, Masao, primary, Nishiyama, Yoshiko, additional, Uetani, Teruyoshi, additional, Ogimoto, Akiyoshi, additional, Ikeda, Shuntaro, additional, Ishimura, Hayato, additional, Watanabe, Emiri, additional, Tashiro, Rami, additional, Tanabe, Yuki, additional, Kido, Teruhito, additional, Kurata, Akira, additional, and Mochizuki, Teruhito, additional

Published
2017
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