Author: "I, Blanco" - Searchworks@Jio Institute Digital Library Search Results

1,346 results on '"I, Blanco"'

101. SURG-23. REOPERATION IN MOLECULAR SUBTYPES OF RECURRENT GLIOBLASTOMA

Author: Jay-Jiguang Zhu, Takeshi Takayasu, Leomar Y. Ballester, Angel I. Blanco, Yoshua Esquenazi, Antonio Dono, Meenakshi B. Bhattacharjee, Sigmund Hsu, Ping Zhu, Nitin Tandon, and Emma Holmes
Subjects: Oncology, Cancer Research, medicine.medical_specialty, business.industry, Internal medicine, Recurrent glioblastoma, Surgical Therapies, medicine, Neurology (clinical), business
Abstract: BACKGROUND Recurrent glioblastoma (rGBM) treatment is not well defined and multiple therapeutic approaches have been proposed, none of which has shown to prolong survival in randomized trials. The role of reoperation for rGBM is still unclear. While most studies demonstrate improve overall survival (OS) and post-progression survival (PPS), recent studies employing time-dependent analysis appear to undermine the OS benefit in reoperated patients. Moreover, the relevance of rGBM molecular subtypes that benefit from reoperation is an important question that may guide clinical decision-making. METHODS A retrospective review of rGBM demographics, clinical, molecular, and outcome characteristics was performed for all cases managed by us between 01/2005 to 10/2019 at our institution. IDH1/IDH2 status was determined by immunohistochemistry and/or next-generation sequencing (NGS). A genetic subanalysis was conducted for most rGBM IDH-wildtype (IDH-WT) by NGS. The primary outcome was PPS. Kaplan-Meier method, multivariable Cox proportional-hazards model, and accelerated failure time model were performed in survival analysis. Random survival forest was applied to identify variable importance. RESULTS 284 rGBM patients fulfill inclusion criteria, 145 (51.1%) had reoperation at their 1st recurrence. Reoperated patients were significantly younger, had better performance status, and had a higher extent of resection at initial surgery; meanwhile, they were less likely to receive bevacizumab. Patients undergoing reoperation experienced superior PPS (11.5 vs. 7.4, months, log-rank test: p= 0.002), which kept consistent in multivariable Cox model (HR: 0.62, p= 0.001). Moreover, reoperated rGBM IDH-WT (N= 238) had 37% reduced risk of post-progression death compared to non-reoperated patients. A subanalysis of rGBM IDH-WT molecular subtypes identified that EGFR mutant, NF1 wildtype, and TP53 wildtype subgroups could benefit from reoperation (all p< 0.008). CONCLUSIONS Maximal safe re-resection improved the PPS of rGBM regardless of their IDH status. Reoperation for 1st recurrence was especially beneficial for GBM IDH-WT harboring EGFR alteration, TP53 WT, and NF1-WT.
Published: 2020

102. EPID-34. THE DETRIMENTAL EFFECT OF BIOPSY PRECEDING RESECTION IN SURGICALLY ACCESSIBLE GLIOBLASTOMAS: RESULTS FROM THE NATIONAL CANCER DATABASE

Author: Nitin Tandon, Angel I. Blanco, Jay-Jiguang Zhu, Xianglin L. Du, Yoshua Esquenazi, Ping Zhu, Leomar Y. Ballester, Constantinos G. Hadjipanayis, and Mitchel S. Berger
Subjects: Cancer Research, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Surrogate endpoint, Objective (goal), Cancer, medicine.disease, Resection, Log-rank test, Oncology, Biopsy, Medical imaging, Medicine, Neurology (clinical), Radiology, Epidemiology & Biostatistics, business, Glioblastoma
Abstract: OBJECTIVES To investigate the impact of biopsy preceding resection compared to upfront resection in glioblastoma overall survival (OS) and post-operative outcomes using the National Cancer Database (NCDB). METHODS A total of 17,334 GBM patients diagnosed between 2010 and 2014 were derived from the NCDB. Patients were categorized into two groups: “upfront resection” versus “biopsy followed by resection”. Primary outcome was OS. Post-operative outcomes including 30-day readmission/mortality, 90-day mortality, and prolonged length of inpatient hospital stay (LOS) were secondary endpoints. Kaplan-Meier methods and accelerated failure time (AFT) models with gamma distribution were applied for survival analysis. Multivariable binary logistic regression models were performed to compare differences in the post-operative outcomes between these groups. RESULTS Patients undergoing “upfront resection” experienced superior survival compared to those undergoing “biopsy followed by resection” (median OS: 12.4 versus 11.1 months, log-rank test: P=0.001). In multivariable AFT models, significant survival benefits were observed among patients undergoing “upfront resection” (time ratio [TR]: 0.83, 95% CI: 0.75–0.93, P=0.001). Patients undergoing upfront GTR had the longest survival compared to upfront STR, GTR following STR, or GTR and STR following an initial biopsy (14.4 vs. 10.3, 13.5, 13.3, and 9.1, months), respectively (TR: 1.00 [Ref.], 0.75, 0.82, 0.88, and 0.67). Recent years of diagnosis, higher income and treatment at academic facilities were significantly associated with the likelihood of undergoing upfront resection after adjusting the covariates. Multivariable logistic regression revealed that 30-day mortality and 90-day mortality were decreased by 73% and 44% for patients undergoing “upfront resection” over “biopsy followed by resection”, respectively (both p < 0.001). CONCLUSIONS Pre-operative biopsies for surgically accessible tumors with characteristic imaging features of Glioblastoma lead to worse survival despite subsequent resection compared to patients undergoing upfront resection.
Published: 2020

103. RADT-06. VOLUME KINETICS FOLLOWING TWO-SESSION GAMMA KNIFE RADIOSURGERY FOR LARGE BRAIN METASTASES (BM)

Author: Angel I. Blanco, Magda Martir, Hatim Chafi, Ethan P Damron, Tse-Kuan Yu, Shariq S. Khwaja, Yoshua Esquenazi, Mark Amsbaugh, and Nitin Tandon
Subjects: Clinical Radiotherapy, Cancer Research, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Gamma knife radiosurgery, Magnetic resonance imaging, Gamma knife, Radiosurgery, Oncology, parasitic diseases, medicine, Neurology (clinical), Session (computer science), Nuclear medicine, business, Volume (compression)
Abstract: INTRODUCTION Resection is a well-established treatment for BM ≥ 2 cm, albeit with potential for perioperative complications and delays in systemic treatment. Staged stereotactic radiosurgery (S-SRS) may improve outcomes versus traditional SRS, representing an alternative to surgery in responders. We reviewed institutional outcomes using 2-session S-SRS, focusing on lesion volume kinetics. METHODS 25 patients with 27 lesions underwent S-SRS at our institution between 2014 and 2020. Tumor volumes (TV) were measured at both S-SRS sessions and on follow-up MRI studies. RESULTS Median age at S-SRS was 61 years (range (r:) 31–84). Nine patients (10 BM) were lost to follow-up. Two patients failed to receive their second S-SRS due to local progression. The median margin tumor doses at first and second S-SRS were 15 Gy (r: 12–18 Gy) and 15 Gy (r: 12–16 Gy). The median interval between stages was 32 days (r: 8–63), and median TV at the first and second stages were 9.3 cm3 (r: 1.5–34.7 cm3) and 3.3 cm3 (r: 0.76–26.1 cm3), respectively. The median absolute and relative decrement between S-SRS sessions was 3.7 cm3 (r: 2.8-16.5 cm3) and 49.5% (r: 17.1-87.1%), respectively. [1-2]-month, [3-5]-month, and [6-12]-month MRI scans were available for 17, 10, and 15 lesions. The median decrease in TV compared to baseline was 50.2%, 78.2%, 74.9%. Two of 17 lesions (12%) had initial control but subsequently experienced volumetric progression and required resection. There were no G3+ adverse events (AE). Crude tumor control was achieved in 14 of 17 individual lesions (82%). CONCLUSION Two-session S-SRS is an effective treatment modality for treating patients with large BM, which is feasible in over 80% of patients with sustained tumor control and early volumetric regression.
Published: 2020

104. Role of Ethnicity and Geographic Location on Glioblastoma IDH1/IDH2 Mutations

Author: Ankush Bhatia, Ryan M McCormack, Takeshi Takayasu, Antonio Dono, Leomar Y. Ballester, Nitin Tandon, Ping Zhu, Quinn T. Ostrom, Yoshua Esquenazi, Sergio Moreno, Alberto Gonzales, and Angel I. Blanco
Subjects: Oncology, Male, medicine.medical_specialty, IDH1, Referral, Population, Ethnic group, IDH2, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, education, Survival analysis, Aged, Retrospective Studies, education.field_of_study, business.industry, Brain Neoplasms, Retrospective cohort study, Middle Aged, Isocitrate Dehydrogenase, Cancer registry, 030220 oncology & carcinogenesis, Mutation, Surgery, Female, Neurology (clinical), business, Glioblastoma, 030217 neurology & neurosurgery
Abstract: Previous studies have demonstrated possible differences in glioblastoma (GBM) survival attributable to ethnicity. The goal of this study was to quantify oncogenic differences and evaluate the overall survival (OS) and progression-free survival (PFS) differences in GBM patients across race/ethnicity using both population-based surveillance and institutional data sets from the United States (US) and Mexico.Retrospective cohort study comprising the Texas Cancer Registry (TCR, n = 4134) and referral institutions located in US (n = 254) and Mexico (n = 47) were evaluated. Primary outcomes include OS and PFS. Oncogenic differences attributable to ethnicity were assessed. IDH1/IDH2 status was evaluated by sequencing in US and Mexico samples. Kaplan-Meier and Cox proportional hazards regression for survival analysis.A total of 4134 GBM patients were identified from the TCR data set, ethnicity comparison demonstrated that Hispanic patients were diagnosed at a significantly younger age compared to non-Hispanic white patients (NHW) (median: 58 vs. 62, P0.001) and had improved OS (hazard ratio: 0.82, P0.001). In the oncogenic analysis, we observed a significant enrichment of IDH1/IDH2 mutations in Mexican Hispanic patients compared to US Hispanic patients (29.8% vs. 7.9%, P = 0.012); IDH2 mutations drove this difference. Post-progression survival was significantly shorter in patients from Mexico than US (3.0 vs. 11.4 months; P0.001), while OS remained similar.IDH2 mutations are more prevalent in Mexican Hispanic individuals compared to US individuals and may be a crucial contributor to the previously reported survival benefit of Hispanic individuals in large population databases. These findings are critical for both screening of IDH2 mutations and targeted interventions in GBM.
Published: 2020

105. A DUF4148 family protein produced inside RAW264.7 cells is a critical Burkholderia pseudomallei virulence factor

Author: Udoka Okaro, Jennifer Chua, Susan L. Welkos, David DeShazer, and Irma I. Blanco
Subjects: Microbiology (medical), Melioidosis, Burkholderia pseudomallei, Virulence Factors, Domain of unknown function, education, Immunology, Endocytic cycle, Infectious and parasitic diseases, RC109-216, Select agent, Microbiology, Virulence factor, 03 medical and health sciences, Mice, Bacterial Proteins, medicine, Animals, health care economics and organizations, 030304 developmental biology, 0303 health sciences, Mice, Inbred BALB C, biology, Virulence, 030306 microbiology, Macrophages, bacterial infections and mycoses, medicine.disease, biology.organism_classification, Antibodies, Bacterial, Macaca mulatta, Infectious Diseases, RAW 264.7 Cells, facultative intracellular pathogen, select agent, bacteria, Parasitology, Female, Research Article, Research Paper
Abstract: Burkholderia pseudomallei: is the etiological agent of the disease melioidosis and is a Tier 1 select agent. It survives and replicates inside phagocytic cells by escaping from the endocytic vacuole, replicating in the cytosol, spreading to other cells via actin polymerization and promoting the fusion of infected and uninfected host cells to form multinucleated giant cells. In this study, we utilized a proteomics approach to identify bacterial proteins produced inside RAW264.7 murine macrophages and host proteins produced in response to B. pseudomallei infection. Cells infected with B. pseudomallei strain K96243 were lysed and the lysate proteins digested and analyzed using nanoflow reversed-phase liquid chromatography and tandem mass spectrometry. Approximately 160 bacterial proteins were identified in the infected macrophages, including BimA, TssA, TssB, Hcp1 and TssM. Several previously uncharacterized B. pseudomallei proteins were also identified, including BPSS1996 and BPSL2748. Mutations were constructed in the genes encoding these novel proteins and their relative virulence was assessed in BALB/c mice. The 50% lethal dose for the BPSS1996 mutant was approximately 55-fold higher than that of the wild type, suggesting that BPSS1996 is required for full virulence. Sera from B. pseudomallei-infected animals reacted with BPSS1996 and it was found to localize to the bacterial surface using indirect immunofluorescence. Finally, we identified 274 host proteins that were exclusively present or absent in infected RAW264.7 cells, including chemokines and cytokines involved in controlling the initial stages of infection.
Published: 2020

106. Gas Exchange Impairment in Chronic Obstructive Pulmonary Disease with Severe Pulmonary Hypertension

Author: A. Ramírez, Yolanda Torralba, Felip Burgos, Concepción Gistau, Joan Albert Barberà, J. Moisés, Lucilla Piccari, I. Blanco, and Ebymar Arismendi
Subjects: medicine.medical_specialty, business.industry, Internal medicine, Gas exchange impairment, medicine, Cardiology, Pulmonary disease, business, medicine.disease, Pulmonary hypertension
Published: 2020
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107. Improving Home Oxygen Therapy in Patients with Interstitial Lung Diseases (ILDS): Application of a Portable Non-Invasive Ventilation (NIV) Device

Author: S. Cuerpo Carde osa, M. Palomo, J.R. Francesqui Candela, J. Sellares Torres, I. Blanco, Fernanda Hernandez-Gonzalez, and C. Embid
Subjects: Lung, medicine.anatomical_structure, business.industry, Home oxygen therapy, Anesthesia, medicine, In patient, business
Published: 2020
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108. Home Monitoring with a Portable Oxymeter as an Alternative Method to Assess Oxygen Saturation During Daily Activities in Interstitial Lung Diseases (ILDS)

Author: M. Palomo, J. Sellares Torres, I. Blanco, J. Francesqui, Fernanda Hernandez-Gonzalez, S. Cuerpo Carde osa, and C. Embid
Subjects: Alternative methods, Lung, medicine.anatomical_structure, business.industry, Anesthesia, Medicine, business, Oxygen saturation (medicine)
Published: 2020
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109. Safety of hospital discharge before return of bowel function after elective colorectal surgery

Author: J Chapman, S, Blanco-Colino, R, Pérez-Ajates, S, O Anabitarte Bautista, Hodson, J, C Glasbey, J, Pata, F, Pellino, G, Sgrò, A, Soares, A, T van Elst, S Van Straten, Nepogodiev, D, Borakati, A, F Bath, M, H Yasin, I, Mclean, K, Arthur, T, Kovacevic, M, Delibegovic, S, Karamanliev, M, Swamad, M, Žebrák, R, Paramasivam, R, Martensen, A, M Larsen, H, Rädeker, L, E Frey, P, Kechagias, A, Venara, A, Duchalais, E, Ioannidis, A, Pasquali, S, Simioni, A, Farina, V, Podda, M, Lorenzon, L, Schaeff, V, Otto, A, Jakubauskas, M, R van Elst, T, Chu, M, Pvb, Fagan, I Wells, C, A Alagoa João, Juloski, J, Y El Kasmy El Kasmi, Espin-Basany, E, Clerc, D, Ciubotaru, C, Popescu, S, Yanishev, A, Lee, S, B Ozkan, B, A Yagız Sen, K Aktas, M, E Baki, B, Yüksek, B, Kamarajah, S, A Khaw, R, Mills, E, Goodson, R, Thakral, N, D Ablett, A, Adra, M, Kwek, I, M Khan, S, Quinn, P, R Manley, L, Badran, A, Ramjeeawon, A, Campbell, A, L Tan, H, S Rye, D, Rajaraman, N, G Norman, J, Vutipongsatorn, K, Solomou, G, Akhbari, M, Ali, A, Murray, V, M Baker, D, D Brandao, B, Stainer, B, Thavayogan, R, Jones, D, O Onafowokan, O, Gharooni, A, Dabab, N, Carlton-Carew, S, Kungwengwe, G, Gabriel, M, Sewart, E, C Shortland, T, Lawday, S, Pockney, P, Dawson, A, D Brumfitt, C, Stewart, P, B, Ng, K Luong, J, Ivanov, V, Borisova, A, Neykov, V, Kunčarová, K, Kološová, B, Antonova, T, Farkašová, M, L Harbjerg, J, Brandsborg, S, Brinck, S, D Kjaer, M, Mark-Christensen, A, P Unbehaun, K, Dalsgaard, P, D Lycke, K, Lenaoures, P, Brigand, C, Dumange, E, Gout, M, Moehwald, C, Prem, M, Alhalabi, O, Sliwinski, S, Krupp, J, Gablenz, E, Schmitzer, L, Kopp, A, Steinle, J, Gsenger, J, J Pohl, L, Riccardi, M, M Christodoulou, I, Konstantinidis, M, Machairas, N, Zoikas, A, Balalis, D, K Manatakis, D, L Aguilera, M, Marano, L, Fleres, F, Lovisetto, F, Sasia, D, Segalini, E, Pata, G, Lucchi, A, Sagnotta, A, Campagnaro, T, Petrelli, F, Gallo, G, Papandrea, M, Testa, V, Sinibaldi, G, F Di Candido, Colombo, F, Perrone, G, Aresu, S, Biancafarina, A, Canonico, G, Pagnanelli, M, Curletti, G, Bini, R, A de Manzoni Garberini, Impellizzeri, H, Cillara, N, Tutino, R, Picciariello, A, Coletta, D, Savino, G, Ferrara, F, Tamini, N, Talamo, G, Parini, D, Giamundo, P, A Lo Conte, Pagano, G, Ripetti, V, Pesce, A, Menduni, N, Giudicissi, R, Goldin, E, Rega, D, Belli, A, Andriola, V, Gordini, L, Foppa, C, Piccolo, G, Birindelli, A, Ferrari, C, Ballarini, Z, Tirelli, F, Milone, M, M De Rosa, S Pipitone Federico, N, Molteni, B, L Tilocca, P, Sancini, G, N Piozzi, G, Lauretta, A, Poillucci, G, Mulas, S, Simcikas, D, Portelli, L, Jwm van Wijnbergen, L Dinger, T, Sfh Ten Doesschate, Ashm van Dalen, D van den Bos, D, Hansmann, M, J Medina Feliz, Z Kuiper, S, Abdulrahman, Z, R Pruijssers, S, Farik, S, M Elliott, B, P Geneta, V, Wilton, S, Kandelaki, H, L Peng, S, Campbell, S, K Lim, Y, S Yassaie, S, Murray, M, Haran, C, Tan, J, Castro, J, Laranjeira, A, Catarino, S, Neves-Marques, C, G Correia, J, N Vieira, B, C Quintela, A, L Serra, M, Maciel, J, Cunha, M, J Aparício, D, Neves, J, Azevedo, J, Romano, M, Eiró, F, Romano, J, Monteiro, C, Claro, M, R Almeida, M, Peyroteo, M, D Machado, N, Capote, H, Ferreira, M, Sousa, X, Devesa, H, Cavadas, D, Guerreiro, I, Costa, M, Rosete, M, Salman, M, English, C, Mohammed, N, Litvin, A, V Ćuk, V, Mészárosová, K, Jaich, R, H De Lima, Brooks, S, Marx, M, M Nshalati Salvation, J García Cardo, Mora-Guzmán, I, J Sancho Muriel, U de Andres Olabarria, Muriel, P, C Jimenez Viñas, Alconchel, F, O Esteban Sinovas, C Fairén Oro, M López Otero, S Figueroa Jiménez, O Claramonte Bellmunt, J Martínez Caballero, Rubio-Pérez, I, M Aguilar-Martínez, M, J Segura-Sampedro, J, C Olmedo Moreno, D Negre Parra, M Estévez Diz, A, Martín-Balbuena, R, C Bustamante Recuenco, E Licardie Bolaños, R, Fernández, P, A Díaz Padillo, Forero-Torres, A, I Alberdi San Román, H Salvador Rosés, M Merayo Álvarez, P Villarejo Campos, C Lopes Moreira, C, P Uriol Peralta, M Serrano Navidad, Ripollés-Melchor, J, Garcea, A, H Gómez Facundo, P Troncoso Pereira, V Pérez Guarinos, C, Blaser, B, Piazza, G, Gagliardi, B, Serin, H, S Yurdaor, S, Arslan, E, Kopac, O, Uyanik, A, B Ozmen, B, Tiftik, E, Aksoy, B, Yalcinkaya, A, Ozoglu, F, D Kocer, M, Bilicen, G, N Cinar, E, Uslu, Ö, Kaya, Y, Demirci, K, Wong, J, Mmh, Farhan-Alanie, Suresh, G, Asif, A, J Finch, B, Bhahirathan, Y, Herron, J, Z Yi Tew, Obukofe, R, Russell, C, Suchett-Kay, I, Netke, T, Williams, L, Kisiel, A, Y Liu, F, Claireaux, H, James, P, Mondal, A, Kalderon, R, H Nadama, H, Al-Saraff, Z, Jph, Tam, Powell-Chandler, A, Wood, F, Rebecca, Gorgievska, Ragavoodoo, A, Thakrar, C, Rojoa, D, Palmer, C, Davidson, K, Giacci, L, Hale, J, W Gan, F, Makin-Taylor, R, Y Hey, C, Toh, C, M Findlay, J, Griffiths, N, Ganesananthan, S, Jasionowska, S, Poustie, M, Wong, C, Turner, T, Pyc, W, Sloper, W, Warner, C, Coey, J, Mason, D, Sait, S, Kowal, M, Owen, M, Saiyed, A, Ashworth, I, Akbari, K, Curran, M, Martin, P, Parker, D, Kwok, K, Lye, C, Ghaly, M, Sammour, T, Lewis, D, Mundasad, R, Wilkes, A, Ctercteko, G, Maslyankov, S, Dimov, R, Iliev, S, Dimitrov, D, Marek, F, Örhalmi, J, Skalický, P, Skalický, T, Chrz, K, Christensen, P, Worsøe, J, S Kristensen, E, J Emmertsen, K, S Loeve, U, L Mihaljevic, A, Herrle, F, M Konstantinidis, K, Korkolis, D, Karanikas, I, Vincenti, L, Anania, G, Borghi, F, Agresta, F, Maretto, I, Parisi, A, Bucci, L, G De Palma, Guglielmi, A, Cucinotta, E, F La Torre, Cianchi, F, Guerrieri, M, Trompetto, M, Persiani, R, Micheletto, G, Delrio, P, Cantafio, S, Ronconi, M, Pag, Bisagni, M De Prizio, Franceschi, A, Galleano, R, Cavallini, M, Brescia, A, D'Ambra, L, Benevento, A, Niolu, P, Calgaro, M, Colangelo, E, Grottola, T, F Altomare, D, Puleo, S, Salamone, G, Pietrabissa, A, Poggioli, G, Erdas, E, Ottonello, R, Tonini, V, Selvaggi, F, Sammarco, G, Ceccarelli, G, C De Nisco, Surgo, D, Taglietti, L, Ozolins, A, Sivinš, A, Poskus, T, Psaila, J, A Bemelman, W, J Graat, L, Langenhoff, B, Bpl, Wijnhoven, Ahw van de Ven, Poelman, M, Lps, Stassen, Slooter, G, Yiz, Acherman, Hoff, C, F Gerhards, M, Mwj, Stommel, J Hazebroek, E, Aaw van Geloven, A Schasfoort, R, L van Leeuwen, B, B Tuynman, J, Mwa van Tilburg, G Boerma, E, Sharma, P, Jenkins, B, P Bissett, I, Herd, A, Gordon, A, Vernon, D, Omundsen, M, J, Ly, Reddy, A, Bonnet, G, Harmston, C, Morales, M, Francisco, V, Costa, S, Manso, A, Amorim, E, Pereira, J, Cardoso, J, Ourô, S, Caratão, M, Nascimento, C, B Ribeiro da Silva, Taranu, V, Dias, R, Mendes, J, Allen, M, Silva, A, Carlos, S, Barbosa, E, Carneiro, C, Ramos, L, Lencastre, L, Martins, R, Silva-Vaz, P, F Ridgway, P, A McNamara, D, Cahill, R, Hogan, A, Larkin, J, R O'Connell, P, Negoi, I, Abelevich, A, M Ćuk, V, Vician, M, Ede, C, Sardiwalla, I, Mulira, S, Montwedi, D, Oyomno, M, Sabia, D, V Portugal Porras, Vigorita, V, G Sanz Ortega, García, J, A Espí Macías, F Blanco Antona, A Luján Mompeán, J, S Salvans Ruiz, Villarejo-Campos, P, M Romero Simó, Sánchez-Guillén, L, M Jiménez-Gómez, L, A Sánchez López, Golda, T, D Julià Bergkvist, Nevado, C, F Noguera Aguilar, J, B Ricardo Felipe, Septiem, J, A Rodríguez Sánchez, Cañete-Gómez, J, I Ruiz Montesinos, Millán-Scheiding, M, Prieto-Nieto, I, Frasson, M, D García Olmo, Hübner, M, Petermann, D, O Sauvain, M, Ozben, V, E Geçim, I, Disçi, E, Rencuzogullari, A, Kurt, A, Bisgin, T, Pehlivan, M, Isik, A, Onur, E, Leventoglu, S, C Haksal, M, S Erturk, M, Keskin, M, Guner, A, S Tutcu Sahin, S Ozbalci, G, Pergel, A, Albayrak, D, Bruce, D, Fearnhead, N, Arthur, J, Harron, M, Beattie, G, Titu, L, Saunders, M, Phillips, J, Dindyal, S, Cresswell, B, Gercek, Y, Lee, J, Linn, T, Faulkner, G, Lockwood, S, Rees, J, Charalabopoulos, A, Campbell, B, Kontovounisios, C, Amarnath, T, Johnson, M, Epanomeritakis, E, Vigs, S, Nastro, P, Gilliam, A, Smolarek, S, Wilson, T, Orbell, J, Mcintyre, R, Agarwal, T, Hainsworth, P, Patel, P, Vijay, J, Liu, B, P Dhruva Rao, Roxburgh, C, Vipond, M, Youssef, H, Thorn, C, Schizas, A, Denley, S, Bowley, D, Das, K, Cuming, T, Saha, A, Chung, L, Pitt, J, Davis, P, Jones, O, Taylor, M, Bhargava, A, Haji, A, Watson, N, Bloom, I, Singh, B, Norwood, M, Gurjar, S, Stylianides, N, Mirza, S, Evans, M, Williams, G, Patil, P, Hernon, J, Finch, G, Green, S, Chapple, K, Fafemi, O, Warusavitarne, J, Samee, A, Carden, C, Ong, L, Verma, K, Joseph, A, Rawat, N, Pinkney, T, Oke, O, Glen, P, Maxwell-Armstrong, C, Oliphant, R, Garner, J, J Moug, S, Middleton, S, N Lund, J, J Smart, N, Osborn, G, Moore, T, Raymond, T, H Knowles, C, S Hany, T, Clarke, R, Khera, G, Brady, R, Sellahewa, C, Mason, C, Torrance, A, Lasithiotakis, K, Knight, J, Pullybank, A, Ainsworth, P, Reid, F, Ramwell, A, Maslekar, S, George, R, Skull, A, Holtham, S, Muhammad, K, Lal, R, Varcada, M, M Smith, F, Howlader, M, Defriend, D, Kirk, S, Richards, T, Evans, C, M Borg, C, Telford, K, Sarfraz, N, Busby, K, Hollingshead, J, Speake, D, Pawa, N, West, D, Chadwick, M, Komolafe, O, Richardson, S, Thornton, M, Goede, A, Osborne, C, Bandyopadhyay, D, 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V., Escovar, F. J., Fernandez, M. C., Martinez, A. P., Bergara, I. B., Olavarria, A. L., del Pozo Andres, E., Ortega, C., Arias-Camison, P. L., Arranz, J. M. N., Sexmero, M. J. M., Alonso, E. D., Moreno, A. I., Margarida, A., Pando, B., Marin, L. L., Calle, M. P., Cordero, M. J. R., Cuartango, A. S., Sanchez, E., Rodrigo, A. M., Diago, J. P., Lista, M. V., Terricabras, S. R., Sanz, L. B., Camprubi, E. A., Ferrandez, M. R., Lao, E. P., Miro, M. D. P., Alberca-Paramo, A., Verdejo, T. A., Canete-Manzanares, J., Molina-Florez, M., Hernandez, L. C. G., Nunez, S. O., Suarez-Sanchez, M., Martin-Fernandez, J., Liebana, M. M. S., Betancourth, C. F. C., Mico, S. S., Fernandez, A., Curtis, C., Bosch, M., Triguero, D., Ramirez, M. B., Diaz, N. R., Caraballo, I. G., Vicente, T. P., Orue-Echebarria, M. I., Sanchez-Calvo, L., Wang, D., Trueba-Collado, C., de Quiros, J. T. M. B., Jimenez, F. A. R., Ortega, A. P., Barbadillo, A. T., Pujana, E. R., Illera, M. V. F., Serralvo, A. D. L. 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J., Lam, S., Chipeta, C., Jain, C., Garofalidou, T., Novotny, S. A., Locke, S., Bowman, C., Begaj, A., Murphy, C., Radcliffe, K., Chong, J. T., Jeffrey, E., Chaudhury, N., Rajendran, K., Akbar, Z., Walters, B., Kulendrarajah, B., Tran, N., Shrestha, S., Parmar, S., Gallagher, C., Hennessy, L., Pentti, E., Badhrinarayanan, S., Fung, A., Mansoor, M., Kenny, R., Kan, P., Lee, D. E., Khosla, S., Samake, M., Shaban, F., Aftab, R., Gough, M., Woodburn, B., Vayalapra, S., Mcmurrugh, K., Jimulia, D., Deol, S., Pike, S., Embury-Young, Y., Patel, M., Kilgallon, E., Keating, R., Walsh, A., Khan, H., Logue, G., Orekoya, M., Alasmar, M., Charalambides, M., Llavall, A. C., Williamson, E., Bharwada, Y., Zearmal, S., Evans, H., Panikkar, M., de la Cruz, G., Caplan, J., Ruparelia, A., Tanvir, T., Soare, C., Pang, Y. 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B., Hoo, M., Gopaul, A., Scanlon, K., O'Dwyer, N., Jovanovic, M., Panyko, A., Van Vuuren, S., Centeno, A., Bernado, I. R., Senorans, M. P. G., Amor, L. G., Ramirez, A. C., Abrisqueta, J., Gomez, M. E., Arroyo, A., Cerdan, C., Romeu, N. G., Enriquez-Navascues, J. M., Collado-Roura, F., Curchod, P., Gaspar, S., Imadalou, L., Mutlu, D., Akyol, C., Uygur, F. A., Eray, I. C., Biyiklioglu, O., Cetin, M. F., Isik, A. E., Karip, B., Dogan, H., Sarigul, L., Tunc, E., Aydin, T., Bodur, S., Karabulut, K., Francis, A. A., Al-hadithi, A., Lau, I. S. F., Smith, E., Mahapatra, S., Mcauliffe, O., Imam, L., Akram, B., Hossaini, S., Davies, R., Ko, M., Collins, J., Pandya, A., Reilly, S., Archer, J., Livie, J., Chaudhry, F. A., Ntakomyti, E., Diallo, R., Bylinski, T., Wright, J., Masiha, E., Tung, J., Shirazi, B., Neilson, A., Epton, S., Patel, N., Trussell, S., Couldrey, A., and Donnelly, C.
Subjects: operative, Male, postoperative discharge, Postoperative Complications, 0302 clinical medicine, Colostomy, CRITERIA, Prospective Studies, Bowel function, Colectomy, IMAGINE, stoma, intestines, Proctectomy, Ileostomy, digestive, oral, and skin physiology, patient discharge, colorectal surgery, hospital discharge, bowel function, RECOVERY, Middle Aged, adult, colostomy, elective surgical procedures, female, follow-up studies, humans, ileostomy, ileus, male, middle aged, multivariate analysis, patient readmission, patient safety, postoperative complications, prospective studies, recovery of function, colectomy, proctectomy, Patient Discharge, Colorectal surgery, ileus - - discharge - bowel function - elective - colorectal surgery, Elective Surgical Procedures, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Patient Safety, Cohort study, safety, Adult, medicine.medical_specialty, Ileus, Patient Readmission, defecation, 03 medical and health sciences, medicine, Hospital discharge, Humans, colorectal surgery, colorectal resection, Colorectal resection, defecation, postoperative complications, colorectal surgery, intestines, patient discharge, patient readmission, safety, surgical procedures, operative, colorectal resection, ileus, business.industry, Recovery of Function, Odds ratio, medicine.disease, digestive system diseases, surgical procedures, Surgery, Multivariate Analysis, Defecation, business, Follow-Up Studies
Abstract: Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function.A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien-Dindo classification system.A total of 3288 patients were included in the analysis, of whom 301 (9·2 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4-7) and 7 (6-8) days respectively (P 0·001). There were no significant differences in rates of readmission between these groups (6·6 versus 8·0 per cent; P = 0·499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0·90, 95 per cent c.i. 0·55 to 1·46; P = 0·659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34·7 versus 39·5 per cent; major 3·3 versus 3·4 per cent; P = 0·110).Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients.El íleo es frecuente tras la cirugía colorrectal y se asocia con un aumento del riesgo de las complicaciones postoperatorias. Identificar las características de una recuperación normal del tránsito y la idoneidad para el alta hospitalaria es una tarea difícil. Este estudio examinó la seguridad del alta hospitalaria antes del restablecimiento de la función intestinal. MÉTODOS: Se llevó a cabo un estudio de cohortes prospectivo y multicéntrico a través de una red de colaboración internacional. Se incluyeron pacientes adultos sometidos a resección electiva colorrectal entre enero y abril 2018. El objetivo principal fue el reingreso hospitalario durante los 30 primeros días tras la intervención. Se utilizó un análisis de regresión multivariable para evaluar el impacto del momento del alta en función del restablecimiento de la función intestinal. El objetivo secundario fue las complicaciones postoperatorias en los primeros 30 días después de la cirugía, valoradas mediante el sistema de clasificación de Clavien-Dindo.Se incluyeron en el análisis 3.288 pacientes, de los cuales 301 (9,2%) fueron dados de alta antes del restablecimiento de la función intestinal. La mediana de la estancia hospitalaria de los pacientes dados de alta antes y después del restablecimiento de la función intestinal fue 5 (rango intercuartílico: 4-7) y 7 (6-8) días, respectivamente (P 0,001). No hubo diferencias significativas en las tasas de reingreso entre estos grupos (6,6% versus 8,0%; P = 0,499), y este resultado se mantuvo en el análisis multivariable tras el ajuste por diferencias basales (razón de opotunidades, odds ratio, OR 0,90; i.c. del 95% 0,55-1,46, P = 0,659). Las tasas de complicaciones postoperarorias fueron similares en aquellos dados de alta antes o después del restablecimiento de la función intestinal (complicaciones menores: 34,7% versus 39,5%; complicaciones mayores 3,3% versus 3,4%; P = 0,110). CONCLUSIÓN: Dar de alta antes del restablecimiento de la función intestinal tras cirugía colorrectal electiva parece ser seguro en pacientes debidamente seleccionados.
Published: 2020
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110. Proposal of a set of indicators for sustainability evaluation of food production in an urban context

Author: Giuliano Vox, Marcio Alexandre Alberti, Evelia Schettini, I. Blanco, Luciene Pimentel da Silva, Alberti, M. A., Blanco, I., Vox, G., Da Silva, L. P., and Schettini, E.
Subjects: Energy, Land use, business.industry, Natural resource economics, Water, Context (language use), Vegetable, NEXUS, Pollution, Urban agriculture, Food, Sustainability, Food processing, business, Set (psychology), Nexus (standard)
Abstract: Urban agriculture (UA) is steadily gaining supporters worldwide, and this is partly because constantly growing urban populations recognize the need to increase food production and promote a healthy diet. UA can also generate extra income, promote socialization leading to valorisation of urban areas. Nevertheless, UA faces several challenges, including limited available space, stressed natural resources, pollution in a context characterized by climate change and new consumption patterns. At the same time, if UA is practiced in the same way as other forms of agriculture, it may have some undesirable environmental impacts on urban areas. The use of indicators can provide decision makers with a tool to evaluate the sustainable insertion of agriculture in cities. This work aims to propose a minimum set of indicators as the basis for an index to assess progress of urban vegetable production towards sustainability. Nineteen urban sustainability indexes, composed of several indicators founded in the literature and already used by several institutions, were analysed. These indexes were broken down into a set of 1579 indicators. Analysis of the relevancy to issues such as food, energy, water, land and pollution, and the selection based on the criteria of being measurable, sensitive to stress, predictable, anticipatory, controllable, integrative, responsive and stable, led to a 26 basic indicators selection. These are proposed as the basis for an innovative UA sustainability index. This will be built based on the Delphi method and is intended to support communities in establishing sustainable and resilient cities.
Published: 2020

111. ¿Qué importancia tiene el bienestar animal para el consumidor?

Author: J Cantalapiedra, M Camiña, I Blanco-Penedo, Y Trillo, and E Fernández
Published: 2020
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112. Clamping, Bending, and Twisting Inter-Domain Motions in the Misfold-Recognising Portion of UDP-Glucose: Glycoprotein Glucosyl-Transferase

Author: Gabor Tax, Angelo Santino, Anu V. Chandran, Snežana Vasiljević, Thomas Waksman, Roberta Ibba, Abhinav Kumar, Lucia Marti, Dominic S. Alonzi, Nicole Zitzmann, Juan I. Blanco Capurro, Johan C. Hill, Marcelo A. Martí, Mario Hensen, Jonathan Rushton, Carlos P. Modenutti, Andrea Lia, Pietro Roversi, and Simone Rubichi
Subjects: chemistry.chemical_classification, Folding (chemistry), A-site, Glycan, chemistry, biology, Endoplasmic reticulum, Biophysics, biology.protein, UGGT, Glycoprotein, Secretory pathway, Accessible surface area
Abstract: UDP-glucose: glycoprotein glucosyltransferase (UGGT) is the glycoprotein folding checkpoint in the eukaryotic glycoprotein secretory pathway. The enzyme detects misfolded glycoproteins in the Endoplasmic Reticulum, and flags them for retention by re-glucosylating them on an N-linked glycan. The fit of a UGGT crystal structure to a negative stain electron microscopy reconstruction of UGGT in complex with an antibody suggests that the misfold-sensing N-terminal portion of UGGT and its C-terminal catalytic domain are tightly associated. Molecular Dynamics (MD) simulations capture UGGT in so far unobserved conformational states, and principal component analysis of the MD trajectories affords a description of UGGT's overall inter-domain motions, highlighting three types of inter-domain movements: bending, twisting and clamping. These inter-domain motions modify the accessible surface area of the enzyme's central saddle. We propose to name "Parodi limit" the maximum distance between a site of misfolding on a UGGT glycoprotein substrate and an N-linked glycan that monomeric UGGT can re-glucosylate on the same glycoprotein. MD simulations estimate the Parodi limit to be around 60-70 A. Re-glucosylation assays using UGGT deletion mutants suggest that the TRXL2 domain is necessary for activity against urea-misfolded bovine thyroglobulin. Our findings support a "one-size-fits-all adjustable spanner" substrate recognition model, with a crucial role for the TRXL2 domain in the recruitment of misfolded substrates.
Published: 2020
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113. Modelling of the Thermal Effect of Green Façades on Building Surface Temperature in Mediterranean Climate

Author: G. Vox, G. Scarascia Mugnozza, Evelia Schettini, I. Blanco, Coppola A., Di Renzo G., Altieri G., D'Antonio P., Blanco, I., Scarascia Mugnozza, G., Vox, G., and Schettini, E.
Subjects: Mediterranean climate, regression model, business.industry, Regression model, Microclimate, Urban green infrastructures, Thermal insulation, Climatology, Urban climate, Evapotranspiration, Urban Green Infrastructures, greenery systems, Environmental science, microclimate, Shading, Urban ecosystem, business, Greenery system, Building envelope
Abstract: Urban Green Infrastructures (UGIs) improve the supply of urban ecosystem services. UGIs can provide benefits such as better urban climate conditions and lower temperature of urban air. They can also limit the development of extreme temperatures on buildings surface, in particular in Mediterranean climate areas. Green facades permit the physical shading of the building envelope, produce a cooling effect by means of evapotranspiration in summer, and improve the thermal insulation in winter. A reduction of the thermal flows between exterior and interior and more sustainable buildings can be obtained. A three years experimental test was carried out at the University of Bari (Italy) for assessing the thermal performance of two green facades characterized by two different climbing plants (Pandorea jasminoides variegated and Rhyncospermum jasminoides). The selected plants well adapt to the local climate, growing quickly and vigorously. The environmental conditions and several climatic parameters on the walls were monitored during the field test. The temperature on the external surface during July 2015 was used for fitting a regression model. The model was validated on July 2016. It can be applied for predicting the two green facades performance in a Mediterranean climate only by using an input dataset on climate conditions.
Published: 2020

114. The Apulian Territory and the Typical Local Farmhouses: A Case of Study Through Landscape Analysis

Author: G. Scarascia Mugnozza, E. Liano, I. Blanco, Coppola A., Di Renzo G., Altieri G., D'Antonio P., Liano, E., Blanco, I., and Scarascia Mugnozza, G.
Subjects: media_common.quotation_subject, Architectural heritage, Rural building, Psychological intervention, Context (language use), Plan (drawing), Touristic itineraries, Local community, Intervention (law), Geography, Promotion (rank), Rural area, Rural buildings, Environmental planning, media_common
Abstract: The Apulian territory is strongly characterized by a rural architectural heritage with many historical features. Rural and agro-industrial buildings, their reuse or degradation, are the testimony of a history whose investigation is complex and varied over time. The Regional Territorial Landscape Plan, which entered into force in 2015, promotes the realization of a self-sustainable and lasting socio-economic development and education for an appropriate use of the regional territory. The knowledge, conservation, use and promotion of the Traditional Apulian Architectural Heritage are among its aims. This in fact constitutes the memory of a place, culturally identifies a local community and the territory. In-depth knowledge of the identifying characteristics of the rural heritage is essential before any recovery intervention specifically aimed at protecting and enhancing the buildings, the landscape and the environmental context. A recovery activity, mindful of these issues, can generate strategic resources for reaching wider objectives of regional development. This study aims to analyze the current relationship between ancient Apulian farmhouses that have been subject to functional restoration interventions and the landscape in which they are located, in order to outline strategies for the development and promotion of the related rural area.
Published: 2020

115. Planned Gamma Knife Boost After Chemoradiotherapy for Selected Sinonasal and Nasopharyngeal Cancers

Author: Martin J. Citardi, Angel I. Blanco, José Armando Díaz-Martínez, Yoshua Esquenazi, Magda Martir, and Ron J. Karni
Subjects: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Gamma knife, Radiosurgery, Young Adult, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, 030223 otorhinolaryngology, Retrospective Studies, Nasopharyngeal cancer, business.industry, Radiotherapy Planning, Computer-Assisted, Nasopharyngeal Neoplasms, Multimodal therapy, Chemoradiotherapy, Middle Aged, medicine.disease, Radiation therapy, Nasopharyngeal carcinoma, 030220 oncology & carcinogenesis, Cavernous sinus, Feasibility Studies, Female, Surgery, Radiotherapy, Intensity-Modulated, Neurology (clinical), Radiology, Complication, business, Paranasal Sinus Neoplasms
Abstract: Objective To determine the feasibility of a Gamma Knife boost after intensity-modulated radiation therapy in combination with multimodal therapy in patients with nasopharyngeal carcinoma and sinonasal malignancies with skull base or cavernous sinus involvement. Methods Nine patients were treated with intensity-modulated radiation therapy followed by a Gamma Knife boost. In one case Gamma Knife was given as salvage treatment after resection. Five patients had sinonasal malignancies and 4 had nasopharyngeal carcinoma. The mean radiation therapy dose was 64.3 Gy (range, 54–70 Gy) at 2 Gy per fraction. The median interval from completion of radiation therapy to Gamma Knife boost was 2.2 months (range, 1–4 months). The most common indication for Gamma Knife boost was involvement of the cavernous sinus, which was identified in 7 patients. The median margin Gamma Knife dose delivered was 13 Gy (range, 12–20 Gy), with median prescription isodose of 50%. Results All patients tolerated the procedure well, with minimal toxicity. Local control rates were achieved in all patients and no acute grade 3–5 toxicity was observed. One patient experienced late grade 4 toxicity, which was potentially attributable to treatment. Distant failure occurred in 3 patients (1 patient with nasopharyngeal carcinoma and 2 patients with sinonasal malignancies). Conclusions Planned Gamma Knife boost followed intensity-modulated radiation therapy is feasible, safe, and provides excellent local control in patients with sinonasal malignancies and nasopharyngeal carcinoma, particularly in cases with cavernous sinus involvement. Further follow-up will be necessary to determine the long-term effectiveness and complication profile.
Published: 2018
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116. Fluciclovine, Anti-1-Amino-3-[18F]-Fluorocyclobutane-1-Carboxylic Acid: A Novel Radiotracer for Meningioma

Author: Yoshua Esquenazi, Robert J. Amato, Leomar Y. Ballester, Quoc Bao Duy Nguyen, Roy Riascos, Angel I. Blanco, and Nitin Tandon
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Pet imaging, medicine.disease, nervous system diseases, 030218 nuclear medicine & medical imaging, Food and drug administration, Meningioma, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Positron emission tomography, 030220 oncology & carcinogenesis, otorhinolaryngologic diseases, medicine, Surgery, Recurrent prostate cancer, In patient, Neurology (clinical), Radiology, business, neoplasms
Abstract: Background Meningiomas are the most common primary intracranial tumors. The current diagnosis and treatment of meningioma is dependent on computed tomography and magnetic resonance imaging, with follow-up management relying mainly on magnetic resonance imaging. The limitations of these structural imaging modalities include delineation of the tumor extent, tumor grade, and differentiation from other meningioma mimickers, especially in or around the skull base. Because studies with positron emission tomography (PET) have shown that PET is able to fulfill some of these gaps, the use of PET for meningiomas has been steadily increasing. Fluciclovine, also known as anti-1-amino-3-[18F]-fluorocyclobutane-1-carboxylic acid (Axumin), is a new PET radiotracer approved by the Food and Drug Administration in 2016 for the detection of suspected recurrent prostate cancer with elevated prostate-specific antigen levels. Because the radiotracer is new, very little is known about the utility of this tracer in brain tumors. Case Description We present 3 cases of meningioma with avid uptake of fluciclovine. In each of these cases, the meningioma was incidentally found during surveillance using PET imaging in patients with prostate cancer. Conclusions These cases illustrate that this new radiotracer has the potential to be a complementary tool in the meningioma workup, treatment, and follow-up, especially for skull base lesions.
Published: 2018
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117. Cognitive disability in adult patients with brain tumors

Author: Carolina Gutiérrez, Faisal Ali, Jiguang Jay Zhu, Leomar Y. Ballester, Yoshua Esquenazi, Maryam R. Hussain, Angel I. Blanco, and Petya Demireva
Subjects: Adult, medicine.medical_specialty, medicine.medical_treatment, Brain tumor, 03 medical and health sciences, Cognitive disabilities, 0302 clinical medicine, Quality of life (healthcare), medicine, Humans, Radiology, Nuclear Medicine and imaging, Intensive care medicine, Depression (differential diagnoses), Chemotherapy, Adult patients, Brain Neoplasms, business.industry, Cognition, General Medicine, medicine.disease, Radiation therapy, Oncology, 030220 oncology & carcinogenesis, Cognition Disorders, business, 030217 neurology & neurosurgery
Abstract: Cognitive dysfunction is common among patients with intracranial tumors. Most cognitive deficits are subtle, lack specificity, may mimic depression or other neurological disorders and may be recognized in retrospect by the physician. In certain cases, distinguishing between tumor recurrence and cognitive deficits that arise as a consequence of the treatment becomes challenging. Late treatment effects have also become an area of focus as the overall survival and prognosis of patients with brain tumors increases. New data has highlighted the importance of less toxic adjuvant therapies owing to their positive impact on prognosis and quality of life. Various experimental therapies and genetic influences on individual sensitivity towards injury are promising steps towards a better management strategy for cognitive dysfunction. In this literature review, we discuss cognitive dysfunction as a manifestation of intracranial tumors, treatment modalities such as radiotherapy, chemotherapy, surgery and their impact on cognition and patients' quality of life. We also discuss management options for cognitive dysfunction and emerging therapies.
Published: 2018
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118. INNV-06. BRAF AND MEK DUAL INHIBITORS THERAPY IN RECURRENT OR ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA (PXA)

Author: Jay-Jiguang Zhu, Meenakshi B. Bhattacharjee, Octavio Arevalo-Espejo, Cornelius Ware, Arthur L. Day, Mark Amsbaugh, Karolina Kata, Yoshua Esquenazi, Nitin Tandon, Antonio Dono, Roy Riascos-Castaneda, Leomar Y. Ballester, Angel I. Blanco, and Juan Carlos Rodriguez Quintero
Subjects: Cancer Research, Oncology, business.industry, Cancer research, Medicine, Neurology (clinical), 26th Annual Meeting & Education Day of the Society for Neuro-Oncology, business, Anaplastic pleomorphic xanthoastrocytoma
Abstract: BACKGROUND AND OBJECTIVE Recurrent and anaplastic pleomorphic xanthoastrocytoma (PXA) tumors are challenging to treat due to their rarity and lack of management consensus. About 80% of PXAs harbor BRAF gene mutation. Although the development of BRAF inhibitors has dramatically improved the outcomes for patients with BRAF V600E mutant tumors, resistance develops in the majority of cases. We hypothesize that dual BRAF/MEK inhibitors therapy can improve tumor control and patient survival without added toxicity. METHODS Medical records from 2010 to 2021 in Memorial Hermann Texas Medical Center were reviewed. Patients diagnosed with PXA who received BRAF and/or MEK inhibitors therapies were identified. The data evaluated included age, sex, treatment received, side effects, and outcomes, as well as results from blood tests, pathology, next generation sequencing and MRI. Side effects were evaluated according to the CTCAE Version 5.0. RESULTS Five patients with recurrent or anaplastic PXA were identified. The median age at diagnosis was 22 years old (range 14-66 years old), with 60% male, and 60% grade III. All patients received BRAF/MEK dual inhibitors therapy at various stages of PXA treatment. The median follow-up was 72 months (range 17-108 months). One patient (66 years old) experienced short-term disease stability for 5 months and who died from tumor related brain hemorrhage while off therapy for 9 months. Four patients experienced long-term disease control (17, 22, 94, 108 months, respectively) while three of them remain on dual therapy and one patient died from systemic PXA progression. Dual BRAF/MEK inhibitors were well tolerated with only grade 1-2 adverse effects (AE) including skin rash, fatigue, mild abdominal discomfort, diarrhea. No grade III-V AE were detected. CONCLUSION BRAF/MEK dual inhibitor can provide potential clinical benefit to PXA patients with BRAF mutations. Our study supports the concurrent use of BRAF/MEK inhibitors for best tumor control without unexpected AE.
Published: 2021
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119. S3275 Metric Differences in Anatomy and Esophageal Pressure Profiles of the Initial Basal Period vs the Final Basal Period in High-Resolution Manometry, Preliminary Report

Author: Eira Cerda Reyes, Pdf, Claudia Pantaleon-Martinez, Eduardo Ramos Raudry, Yolanda Zamorano, cesar montejo velazquez, Luisa V. Fuentes, Edgardo Suárez Morán, José Isidro Minero Alfaro, Jorge Alejandro Villar Tapia, Ana L. Desales Iturbe, Paulina Gálvez Castillejos, Claudia I. Blanco Vela, Martín Uriel Vázquez-Medina, and Julian Gonzalo Gandara-Calderon
Subjects: Basal (phylogenetics), Hepatology, business.industry, Preliminary report, Period (gene), Gastroenterology, Medicine, Esophageal pressure, Metric (unit), business, Nuclear medicine, High resolution manometry
Published: 2021
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120. Sa1697 CHANGES IN ANORECTAL FUNCTION IN PATIENTS WITH SOILING VS FECAL INCONTINENCE

Author: de María, Flor, primary, de Oca Salinas, Montes, additional, Cortés, Juana Donají Martínez, additional, Jáquez, Mariel Alexandra Suárez, additional, Lozano, Nereo G. Salas, additional, Moran, Edgardo Suárez, additional, Zamorano-Orozco, Yolanda, additional, Alfaro, José I. Minero, additional, and Vela, Claudia I. Blanco, additional
Published: 2020
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121. Sa1703 USEFULNESS OF THE LONDON CLASSIFICATION FOR THE DIFFERENTIATION OF ANORECTAL FUNCTION DISORDERS IN PATIENTS WITH CHRONIC CONSTIPATION AND FECAL INCONTINENCE.

Author: Jáquez, Mariel A. Suárez, primary, Cortés, Juana Donají Martínez, additional, Lozano, Nereo G. Salas, additional, de María, Flor, additional, de Oca Salinas, Montes, additional, Zamorano-Orozco, Yolanda, additional, Alfaro, José I. Minero, additional, Vela, Claudia I. Blanco, additional, and Moran, Edgardo Suárez, additional
Published: 2020
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122. Clamping, Bending, and Twisting Inter-Domain Motions in the Misfold-Recognising Portion of UDP-Glucose: Glycoprotein Glucosyl-Transferase

Author: Modenutti, Carlos P., primary, Capurro, Juan I. Blanco, additional, Ibba, Roberta, additional, Alonzi, Dominic S., additional, Vasiljević, Snežana, additional, Kumar, Abhinav, additional, Chandran, Anu V., additional, Tax, Gábor, additional, Marti, Lucia, additional, Hill, Johan C., additional, Lia, Andrea, additional, Hensen, Mario, additional, Waksman, Thomas, additional, Rushton, Jonathan, additional, Rubichi, Simone, additional, Santino, Angelo, additional, Martí, Marcelo A., additional, Zitzmann, Nicole, additional, and Roversi, Pietro, additional
Published: 2020
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123. Alpha-1 antitrypsin deficiency in Italy: regional differences of the PIS and PIZ deficiency alleles

Author: F.J. de Serres, M. Luisetti, I. Ferrarotti, I. Blanco, and E. Fernández-Bustillo
Subjects: Alpha-1 antitrypsin deficiency, PI subtypes, PI phenotypes, population genetics, genetic epidemiology, Medicine
Abstract: Background. Critical to the effective diagnosis and management of disease is information on its prevalence in a particular geographic area such as Italy. Alpha-1- antitrypsin deficiency (AAT Deficiency) is one of the most common serious hereditary diseases in the world, but its prevalence varies markedly from one country to another. AAT Deficiency affects at least 120.5 million carriers and deficient subjects worldwide for the two most prevalent deficiency alleles PIS and PIZ. This genetic disease is known to exist in Italy and is related to a high risk for development of jaundice in infants, liver disease in children and adults, and pulmonary emphysema in adults. Methods. Studies on the genetic epidemiology of AAT Deficiency has resulted in the development of a unique database that permits a unique analysis of the geographic distribution in 14 different regions located at random from Piemonte to Sicilia. Results. The use of Hardy-Weinberg statistical analysis to evaluate the distribution of these two deficiency alleles has demonstrated striking differences in the frequencies of these two deficiency alleles in these 14 different regions with 23/84 pair wise combinations significantly different (P=0.05) for PIS, and 5/84 combinations for PIZ. Conclusions. These findings demonstrate differences that impact the standards of care and diagnosis of AAT Deficiency in Italy since the prevalence of these deficiency alleles is not uniform throughout the country.
Published: 2005
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124. Assessment of the environmental loads of green façades in buildings: a comparison with un-vegetated exterior walls

Author: Giovanni Russo, Giuliano Vox, Evelia Schettini, I. Blanco, Blanco, I., Vox, G., Schettini, E., and Russo, G.
Subjects: Environmental Engineering, 0208 environmental biotechnology, 02 engineering and technology, Environment, 010501 environmental sciences, Management, Monitoring, Policy and Law, Cork, engineering.material, 01 natural sciences, Constructive, Thermal insulation, Shading effect, Environmental impact assessment, Waste Management and Disposal, 0105 earth and related environmental sciences, business.industry, LCA, Global warming potential, Building energy, General Medicine, Structural engineering, CML 2001, 020801 environmental engineering, Building envelope, engineering, Carbon footprint, Environmental science, Facade, business
Abstract: Green vertical systems have advantages in terms of building energy performance, but their environmental impact should be assessed in comparison to un-vegetated constructive systems. The aim of this paper was to evaluate the environmental loads of a green façade, which was compared to other building exterior wall systems. A Life Cycle Analysis approach was used to compare the green façade with constructive solutions commonly applied for enhancing the thermal insulation properties of the building exterior walls. The green façade and the other constructive solutions were characterised by an equivalent thermal behaviour. A green façade system prototype, realised with vegetation climbing on a steel frame, was used for the study. The comparison was carried out with exterior walls using insulation materials as expanded polystyrene, expanded cork and wood fibre. A double wall with an un-ventilated air gap was used as well. On average, the best environmental performance was recorded for the wall using cork as insulating material and for the double wall. The results highlighted the environmental criticalities of the green façade as the system having an environmental load among the most burdensome. Different scenarios of green façade with the use of alternative constructive solutions were hypothesized and compared by the life cycle analysis and life cycle impact assessment. The study showed that the adoption of a wooden frame in place of the steel one, as plant supporting structure, reduces the carbon footprint of the green façade by 58%. The environmental comparison was carried out also considering non-vegetated constructive solutions having an equivalent sun shading effect on the wall. The analysis showed that the green façade has the best environmental performance when compared with sun shading systems in aluminium or PVC.
Published: 2021
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125. Energy analysis of a green façade in summer: an experimental test in Mediterranean climate conditions

Author: Evelia Schettini, Giuliano Vox, I. Blanco, Fabiana Convertino, Blanco, I., Convertino, F., Schettini, E., and Vox, G.
Subjects: Convection, Evapotranspiration, 020209 energy, Mechanical Engineering, 0211 other engineering and technologies, Energy flux, 02 engineering and technology, Building and Construction, Atmospheric sciences, Energy saving, Latent heat, 021105 building & construction, Thermal, 0202 electrical engineering, electronic engineering, information engineering, Radiative transfer, Environmental science, Facade, Relative humidity, Heat flux, Electrical and Electronic Engineering, Vertical greening, Cooling effect, Civil and Structural Engineering
Abstract: Energy performance of a double-skin green facade in Mediterranean climate was investigated. Experimental data were collected at a green facade prototype realized at the University of Bari. The green facade thermal behaviour was assessed under different summertime weather scenarios. To point out the plants influence, a comparison was carried out between microclimatic conditions and energy transfer at the covered wall, behind the vegetation, and at an un-vegetated wall. Experimental data concerning the walls surface, the air gap in the green facade and the external air were used to perform statistical analyses and to evaluate the heat fluxes. At daytime, the green facade provided a reduction of the wall surface temperature up to 9.9 °C, while air relative humidity behind the vegetation rose up to 18.7%. Surface and air warming were found at night-time. A time-shift was detected between the maximum surface temperature of the covered and of the bare wall. The analysis of the energy flux through the two walls highlighted a sensible reduction in the covered wall, equal to 62% during daytime. Solar and LWIR radiative and convective fluxes were generally lower in the covered wall. Latent heat due to evapotranspiration was evaluated, as well. Net radiation was found to be the most influencing parameter for latent heat transfer. A simplified relationship was proposed to quantify latent heat due to evapotranspiration. The formula based on the net radiation, as input parameter, was found to be the most suitable. The findings of this research contribute to the knowledge of the effects provided by green facades in terms of cooling and heating, influence on the proximity microclimatic conditions and overall energy transfer.
Published: 2021
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126. Longitudinal monitoring of the head and neck lymphatics in response to surgery and radiation

Author: Syed Naqvi, I-Chih Tan, Melissa B. Aldrich, John C. Rasmussen, Ron J. Karni, Erik A. Maus, Angel I. Blanco, and Eva M. Sevick-Muraca
Subjects: 0301 basic medicine, medicine.medical_specialty, business.industry, medicine.medical_treatment, Head and neck cancer, Cancer, Dissection (medical), medicine.disease, Surgery, Radiation therapy, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Lymphedema, Lymphatic system, Otorhinolaryngology, 030220 oncology & carcinogenesis, medicine, Head and neck, business, Lymph node
Abstract: Background The lymphatic vasculature provides a route for cancer metastases, and its dysfunction after cancer treatment can result in lymphedema. However, changes in the lymphatics before, during, and after surgery and radiation remain unclear. Methods Near-infrared fluorescence lymphatic imaging was performed before and after lymph node dissection and fractionated radiotherapy to assess changes in external lymphatic function. Results Patients who underwent both lymph node dissection and radiotherapy developed lymphatic dermal backflow on treated sides ranging from days after the start of radiotherapy to weeks after its completion, whereas contralateral regions that were not associated with lymph node dissection but also treated with radiotherapy experienced no such changes in external lymphatic anatomies. Conclusion The external lymphatics undergo transient changes during and weeks after lymph node dissection and radiotherapy. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1177-1188, 2017.
Published: 2017
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127. Permanent corneal opacification after refractive surgery with a combined technique: Photorefractive keratectomy (PRK) and accelerated cross-linking (PRK Xtra) in healthy patients

Author: M Gomez-Barrera, Jose M. Abad, V Polo, I Blanco-Dominguez, J Reyes, Á Olate-Perez, and F Duch
Subjects: medicine.medical_specialty, business.industry, medicine.medical_treatment, Corneal Topography, Combined technique, Refraction, Ocular, Photorefractive Keratectomy, Photorefractive keratectomy, Cornea, Ophthalmology, Refractive surgery, medicine, Myopia, Humans, Lasers, Excimer, business
Published: 2019

128. Nuclear elements for drafting a research project with quantitative methodology

Author: J L, Cobo-Sánchez and I, Blanco-Mavillard
Subjects: Epidemiologic Studies, Evaluation Studies as Topic, Research Design, Guidelines as Topic
Published: 2019

129. Application of reflectance confocal microscopy in the evaluation of murine healthy and lesional skin

Author: Pablo Pablo, Jose Luis Montero Egea, Carla Carcasona, Nuria Godessart, Amadeu Gavaldà, Ana I. Blanco, and Merce Pont
Published: 2019
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130. First Report of Fusarium Wilt of Flue-Cured Tobacco Caused by Fusarium oxysporum f. sp. batatas in Spain

Author: I. Blanco, E. Palo, Carolina Palo, L. M. Torres-Vila, J. A. García, M. C. Rodríguez-Molina, G. Espárrago, and E. Verdejo
Subjects: biology, Inoculation, fungi, food and beverages, Wilting, Plant Science, biology.organism_classification, Fusarium wilt, Horticulture, Fusarium oxysporum, Botany, Curing of tobacco, Cultivar, Globodera tabacum, Agronomy and Crop Science, Nicotiana
Abstract: Tobacco (Nicotiana tabaccum L.) is among the most important crops in La Vera Region (Cáceres, west-central Spain) where, since 2001, flue-cured tobacco plants showing typical symptoms of a vascular disease associated to the cyst nematode (Globodera tabacum) complex have been frequently observed (2). Symptoms observed were wilting, yellowing, and drying of the leaves, usually on one side of the plant; stunted and distorted leaves with curved midribs due to the unequal growth; and brown vascular discoloration of stems and midribs. Several diseased plants were collected during the summers of 2003 and 2004, and F. oxysporum was consistently isolated from sections of necrotic midribs. To confirm the pathogenicity of F. oxysporum isolates, plants of flue-cured tobacco (cv. Ct-681) were inoculated. Since Fusarium wilt of tobacco may be caused by F. oxysporum f. sp. vasinfectum or F. oxysporum f. sp. batatas (1), plants of cotton (cv. Acala) and sweet potato (cvs. Nemagold and Nancy Hall) were also inoculated to determine the forma specialis designation. Twenty plants per cultivar and isolate were inoculated with six isolates at the two to four true-leaf stage by pouring into the substrate 200 ml of a conidial suspension (1 × 105 CFU/ml). After inoculation, plants were incubated in a growth chamber at 28°C (day) and 24°C (night) with a 16-h photoperiod. All six F. oxysporum isolates were pathogenic to tobacco and sweet potato, but there were differences among isolates in time from inoculation to appearance of first disease symptoms (7 to 15 days after inoculation in tobacco and sweet potato) and also in disease severity 30 days after inoculation (60 to 100% wilt or mortality in tobacco and 50 to 100% in sweet potato). F. oxysporum was reisolated from stems of inoculated plants. No disease symptom was observed in cotton plants 60 days after inoculation, and F. oxysporum was not reisolated from them. Results of inoculation on the differential hosts indicated that disease symptoms in tobacco were caused by F. oxysporum f. sp. batatas. To our knowledge, this is the first report of F. oxysporum f. sp. batatas causing disease in flue-cured tobacco in Spain. References: (1) G. M. Armstrong and J. K. Armstrong. Phytopathology 58:1242, 1968. (2) G. Espárrago and I. Blanco. Plant Dis. 86:1402, 2002.
Published: 2019

131. Impact of facility type and volume in low-grade glioma outcomes

Author: Ping Zhu, Jay-Jiguang Zhu, Nitin Tandon, Mitchel S. Berger, Leomar Y. Ballester, Yoshua Esquenazi, Xianglin L. Du, and Angel I. Blanco
Subjects: medicine.medical_specialty, business.industry, Tumor resection, Facility type, Retrospective cohort study, General Medicine, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Relative risk, Glioma, Internal medicine, Propensity score matching, Overall survival, Medicine, Low-Grade Glioma, business, 030217 neurology & neurosurgery
Abstract: OBJECTIVEThe object of this study was to investigate the impact of facility type (academic center [AC] vs non-AC) and facility volume (high-volume facility [HVF] vs low-volume facility [LVF]) on low-grade glioma (LGG) outcomes.METHODSThis retrospective cohort study included 5539 LGG patients (2004–2014) from the National Cancer Database. Patients were categorized by facility type and volume (non-AC vs AC, HVF vs LVF). An HVF was defined as the top 1% of facilities according to the number of annual cases. Outcomes included overall survival, treatment receipt, and postoperative outcomes. Kaplan-Meier and Cox proportional-hazards models were applied. The Heller explained relative risk was computed to assess the relative importance of each survival predictor.RESULTSSignificant survival advantages were observed at HVFs (HR 0.67, 95% CI 0.55–0.82, p < 0.001) and ACs (HR 0.84, 95% CI 0.73–0.97, p = 0.015), both prior to and after adjusting for all covariates. Tumor resection was 41% and 26% more likely to be performed at HVFs vs LVFs and ACs vs non-ACs, respectively. Chemotherapy was 40% and 88% more frequently to be utilized at HVFs vs LVFs and ACs vs non-ACs, respectively. Prolonged length of stay (LOS) was decreased by 42% and 24% at HVFs and ACs, respectively. After tumor histology, tumor pattern, and codeletion of 1p19q, facility type and surgical procedure were the most important contributors to survival variance. The main findings remained consistent using propensity score matching and multiple imputation.CONCLUSIONSThis study provides evidence of survival benefits among LGG patients treated at HVFs and ACs. An increased likelihood of undergoing resections, receiving adjuvant therapies, having shorter LOSs, and the multidisciplinary environment typically found at ACs and HVFs are important contributors to the authors’ finding.
Published: 2019

132. Real-life experience of inhaled iloprost for patients with pulmonary arterial hypertension: Insights from the Spanish REHAP registry

Author: Roberto Del Pozo, Pilar Escribano-Subías, Raquel López-Reyes, María Lázaro-Salvador, Teresa Elias-Hernandez, Pablo Álvarez-Vega, Manuel López-Meseguer, I. Blanco, Pedro Bedate, Gregorio Pérez-Peñate, Amaya Martínez-Meñaca, Ignacio Hernández-González, Actelion Pharmaceuticals, Ferrer, GlaxoSmithKline, Merck Sharp & Dohme de España, and Bayer
Subjects: Male, Time Factors, Survival, Vasodilator Agents, Real-life experience, Effectiveness, 030204 cardiovascular system & hematology, Pulmonary arterial hypertension, 0302 clinical medicine, Cause of Death, Forced Expiratory Volume, 030212 general & internal medicine, Prospective Studies, Registries, education.field_of_study, respiratory system, Middle Aged, Treatment Outcome, Female, Cardiology and Cardiovascular Medicine, medicine.drug, Adult, medicine.medical_specialty, Registry, Hypertension, Pulmonary, Population, Prostanoids, Pulmonary hypertension, 03 medical and health sciences, Internal medicine, Administration, Inhalation, medicine, Humans, In patient, Pulmonary Wedge Pressure, Iloprost, education, Survival rate, Aged, Retrospective Studies, Dose-Response Relationship, Drug, business.industry, medicine.disease, Discontinuation, respiratory tract diseases, Spain, Ventricular Function, Right, Observational study, Vascular Resistance, business, Inhaled iloprost, Follow-Up Studies
Abstract: REHAP investigators., [Introduction] REHAP is a voluntary, observational Spanish registry of patients with pulmonary arterial hypertension. We analyzed the experience (use and effectiveness) with inhaled iloprost (inh-ILO) in real-life conditions during a 3-year period., [Methods] Patients included were those with PAH ≥14 years recruited during 1998–2016 who had received inh-ILO. Variables were collected at the beginning of treatment (0 ± 3 months) and 12 ± 3/36 ± 6 months follow-up. Effectiveness was assessed in the intent-to-treat population as changes in functional class and/or physical performance and transplant-free survival from the beginning of treatment. Stopping inh-ILO-related survival was also assessed. Subanalyses included treatment strategy (first-line therapy –monotherapy or upfront combination- or sequential therapy) and risk of clinical worsening/death., [Results] Inh-ILO was the most frequently used prostanoid in Spain, rendering 267 patients eligible for analysis. Median age was 54 years; 61% were WHO FC III. Sixty (23%) patients started inh-ILO as monotherapy, 27 (10%) as upfront combination and 180 (67%) sequentially. At 3-year follow-up significant clinical improvements were observed; however, transplant-free survival rate was 54%, being poorer in patients at high risk (63% vs. 85% in low risk patients; P, [Conclusion] Data from the REHAP collected during 3 years shows that inh-ILO has low effectiveness independently of the treatment strategy used, with a 3-year survival rate of 54% despite significant clinical improvements, probably due to the use in high-risk patients. Discontinuation rate was as high as 75%., We express our gratitude to Actelion, Ferrer, GlaxoSmithKline (GSK) and Merck Sharp & Dohme (MSD) for supporting the REHAP Registry with an unrestricted educational grant.
Published: 2019

133. L'elaboració d'un software per dimensionar xarxes d'enllumenat exterior

Author: Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, SBS, Simon i Blanco, Turmo Coderque, José, Casasampera González, Daniel, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, SBS, Simon i Blanco, Turmo Coderque, José, and Casasampera González, Daniel
Abstract: Es planteja l'elaboració d'un programa informàtic capaç d'importar dades d'un planol autocad i capaç d'elaborar un esquema unifilar de la xarxa, el pressupost i un document de text justificatiu dels calculs (pensat per a ser utilitzat en l'elaboració d'un annex d'enllumenat).
Published: 2019

134. Magnetic study of the Furnas caldera (Azores)

Author: J. M. Torta, A. Garcìa, and I. Blanco
Subjects: Furnas caldera, magnetic anomalies, hydrothermal alteration, Meteorology. Climatology, QC851-999, Geophysics. Cosmic physics, QC801-809
Abstract: A local ground magnetic study of the Furnas caldera (S. Miguel Island, Azores) has provided new insight into the magnetic structure of this volcano. Analysis of the data comprised removal of the IGRF, reduction to the pole, pseudogravity integration and upward continuation. Also, a spectral method was applied to estimate the depth to the magnetic sources, as well as a 2.5D forward modelling technique. Magnetic properties obtained at the laboratory for some representative sample rocks were considered in the modelling process. The most relevant features are the existence of an important negative anomaly inside the caldera and of an intense positive anomaly to the south of the coast. The former points out a decrease in the magnetization of the caldera filling materials with respect to the surrounding rocks, which could be explained as the result of post-eruption processes such as hydrothermal alteration. This is expected as Furnas has an active hydrothermal system probably related with a magmatic reservoir at high temperature. The positive anomaly suggests the existence of a strongly-magnetized body beneath the south coast.
Published: 1997
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135. A search for the volcanomagnetic signal at Deception volcano (South Shetland I., Antarctica)

Author: J. M. Ibáñez, M. M. Astiz, J. M. Torta, I. Blanco, A. Garcìa, and R. Ortiz
Subjects: Deception Island, volcanomagnetic signal, Antartica, Meteorology. Climatology, QC851-999, Geophysics. Cosmic physics, QC801-809
Abstract: After the increase in seismic activity detected during the 1991-1992 summer survey at Deception Island, the continuous measurement of total magnetic intensity was included among the different techniques used to monitor this active volcano. The Polish geomagnetic observatory Arctowski, located on King George Island, served as a reference station, and changes in the differences between the daily mean values at both stations were interpreted as indicators of volcanomagnetic effects at Deception. A magnetic station in continuous recording mode was also installed during the 1993-1994 and 1994-1995 surveys. During the latter, a second magnetometer was deployed on Deception Island, and a third one in the vicinity of the Spanish Antarctic Station on Livingston Island (at a distance of 35 km) and was used as a reference station. The results from the first survey suggest that a small magma injection, responsible for the seismic re-activation, could produce a volcanomagnetic effect, detected as a slight change in the difference between Deception and Arctowski. On the other hand, a long term variation starting at that moment seems to indicate a thermomagnetic effect. However the short register period of only two stations do not allow the sources to be modelled. The future deployment of a magnetic array during the austral summer surveys, throughout the volcano, and of a permanent geomagnetic observatory at Livingston I. is aimed at further observations of magnetic transients of volcanic origin at Deception Island.
Published: 1997
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136. High-resolution aeromagnetic survey of the Teide volcano (Canary Islands): a preliminary analysis

Author: J. M. Torta, I. Blanco, A. Garcìa, and I. Socías
Subjects: Teide, Aeromagnetic anomalies, topographic correction, Meteorology. Climatology, QC851-999, Geophysics. Cosmic physics, QC801-809
Abstract: To contribute to our understanding of the structure of the Teide volcano, a detailed aeromagnetic survey was carried out covering the area of Las Cañadas caldera and the Teide-Pico Viejo complex. Taking into account the rugged relief of the area (altitude ranges from sea level to almost 4000 m), a terrain correction has been applied. As a first approximation, the topography has been characterized by a uniform magnetization of 5 Am-1 (based on field and laboratory rock magnetic data). Several enhancement techniques have been applied to the residual map (original map minus topographic effect), such as reduction to the pole, pseudogravity integration and upward continuation. In the reduced-to-the-pole map the large positive anomaly that appears centered to the north of Pico Viejo is noteworthy and could be caused by a basaltic intrusion responsible for the last eruptions in this area. Also, a small magnetic low appears over Teide peak, which should be related to slightly-magnetized shallow phonolitic materials. The main tectonic direction of Tenerife, SW-NE, is also clearly reflected on the magnetic anomaly map. The comparison between the pseudogravity and the Bouguer anomaly maps indicates a good correlation between magnetic and gravimetric sources.
Published: 1997
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137. Frontoethmoidal osteoma with orbital extension. A case report

Author: B. Moreno García-Rubio, L.M. Martínez González, J. Riba García, I. Blanco Domínguez, G. Franco Iglesias, and A. Oteiza Álvarez
Subjects: medicine.medical_specialty, Sinus drainage, Abstract case, genetic structures, business.industry, Open surgery, Usually asymptomatic, General Medicine, medicine.disease, Slow growth, eye diseases, Surgery, body regions, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Binocular Diplopia, 030221 ophthalmology & optometry, medicine, business, Osteoma, 030217 neurology & neurosurgery, Orbit (anatomy)
Abstract: Case report A case is presented of a right frontoethmoidal osteoma with intraorbital invasion in a 43-year-old male, who was seen in the clinic with a proptosis, retro-orbital pain, peri-palpebral inflammation, and binocular diplopia due to muscular route limitation. Open surgery was performed using a subcranial approach, with removal of several fragments of osteoma. Histological analysis confirmed the diagnosis. Discussion Osteomas are benign bone-forming tumours with slow growth. They are usually asymptomatic until mass effect complications occur in the brain or in the orbit, or locally, generating mucoceles due to sinus drainage obstruction.
Published: 2016
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138. Osteoma frontoetmoidal con extensión intraorbitaria. A propósito de un caso

Author: L.M. Martínez González, A. Oteiza Álvarez, B. Moreno García-Rubio, I. Blanco Domínguez, G. Franco Iglesias, and J. Riba García
Subjects: 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, 030221 ophthalmology & optometry, 030217 neurology & neurosurgery
Abstract: Resumen Caso clinico Presentamos el caso de un osteoma frontoetmoidal derecho con invasion intraorbitaria en un varon de 43 anos que comenzo como un cuadro de dolor retroocular con proptosis, inflamacion peripalpebral y diplopia binocular por limitacion del recorrido muscular. Se realizo cirugia abierta mediante abordaje subcraneal anterior, con extirpacion de varios fragmentos de osteoma, cuyo analisis histologico confirmo el diagnostico. Discusion Los osteomas son tumores benignos formadores de hueso de crecimiento lento. Habitualmente son asintomaticos, hasta que producen complicaciones por efecto masa en el cerebro o en la orbita, o a nivel local, hasta que obstruyen el drenaje del seno donde asientan, generando mucoceles.
Published: 2016
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139. Durable response of glioblastoma to adjuvant therapy consisting of temozolomide and a weekly dose of AMD3100 (plerixafor), a CXCR4 inhibitor, together with lapatinib, metformin and niacinamide

Author: Sigmund Hsu, Robert E. Brown, Angel I. Blanco, Arthur L. Day, Adan Rios, Jamie Buryanek, and Mary F. McGuire
Subjects: 0301 basic medicine, Cancer Research, biomedical analytics, Angiogenesis, medicine.medical_treatment, Case Report, Pharmacology, preventative and targeted therapy, Lapatinib, CXCR4, 03 medical and health sciences, 0302 clinical medicine, Adjuvant therapy, Medicine, Temozolomide, business.industry, Plerixafor, glioblastoma, plerixafor, 030104 developmental biology, Oncology, morphoproteomics, 030220 oncology & carcinogenesis, Cancer research, business, Adjuvant, Chemoradiotherapy, medicine.drug
Abstract: Glioblastoma multiforme (GBM) is a CNS (central nervous system) malignancy with a low cure rate. Median time to progression after standard treatment is 7 months and median overall survival is 15 months [1]. Post-treatment vasculogenesis promoted by recruitment of bone marrow derived cells (BMDCs, CD11b+ myelomonocytes) is one of main mechanisms of GBM resistance to initial chemoradiotherapy treatment [2]. Local secretion of SDF-1, cognate ligand of BMDCs CXCR4 receptors attracts BMDCs to the post-radiation tumor site.[3]. This SDF-1 hypoxia-dependent effect can be blocked by AMD3100 (plerixafor) [4]. We report a GBM case treated after chemo- radiotherapy with plerixafor and a combination of an mTOR, a Sirt1 and an EGFRvIII inhibitor. After one year temozolomide and the EGFRvIII inhibitor were stopped. Plerixafor, and the MTOR and Sirt-1 inhibitors were continued. He is in clinical and radiologic remission 30 months from the initiation of his adjuvant treatment. To our knowledge, this is the first report of a patient treated for over two years with a CXCR4 inhibitor (plerixafor), as part of his adjuvant treatment. We believe there is sufficient experimental evidence to consider AMD3100 (plerixafor) part of the adjuvant treatment of GBM. Significance The adjuvant inhibition of GBM vasculogenesis(a process different from local angiogenesis) by specifically blocking the migration of BMDCs to the primary tumor site with inhibitors of the CXCR4/SDF-1 axis represents a potential novel therapeutic approach to GBM. There is significant pre-clinical evidence and validation for its use as demonstrated in a patient derived tumor xenograft model of GBM. Together with other specific anti-tumoral therapies, the active inhibition of vasculogenesis in the adjuvant treatment of GBM is deserving of further exploration.
Published: 2016
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140. Taxonomic status of Cyathostoma nematodes (Nematoda: Syngaminae) parasitizing respiratory tracts of birds of prey and owls in Europe and North America: how many species are there?

Author: Gerard Kanarek, Grzegorz Zaleśny, Jiljí Sitko, and A I. Blanco
Subjects: 0301 basic medicine, Medicine (General), Ecology, Agriculture (General), cyathostoma (hovorkonema), Zoology, its-2, 030108 mycology & parasitology, Biology, Molecular taxonomy, Predation, S1-972, 03 medical and health sciences, 030104 developmental biology, R5-920, Helminths, birds of prey, Animal Science and Zoology, Parasitology, Taxonomy (biology), nematoda, Natural enemies, Cyathostoma, owls, syngamidae
Abstract: Summary So far, the identity of Cyathostoma (Hovorkonema) nematodes collected from respiratory tracts of birds of prey (Accipitriformes, Falconiformes) and owls (Strigiformes) in Europe and North America is extremely inconsistent. Our results, based on analyses of ITS-2 sequences suggest that the Cyathostoma (Hovorkonema) nematodes found in the birds of prey and owls from Central Europe and North America probably belong to the same species, C. (Hovorkonema) americanaChapin, 1925. We are convinced, that described in recent literature high ITS-2 divergence among C. (Hovorkonema) nematodes collected from Europe, has occurred as a result of invalid synonimisation of some C. (Hovorkonema) species. In our opinion C. (Hovorkonema) americana (typically parasites of tracheae and air sacs of raptors) and C. (Hovorkonema) variegatum (Creplin, 1849) (typically parasites of tracheae of cranes and storks) are valid molecular and morphologically distinct species.
Published: 2016

141. Resultados de la cirugía de estrabismo mínimamente invasiva en las desviaciones horizontales

Author: I. Blanco Domínguez, P. Merino, and P. Gómez de Liaño
Subjects: 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, 030221 ophthalmology & optometry, 030217 neurology & neurosurgery
Abstract: Resumen Objetivo Estudiar los resultados de la cirugia de estrabismo minimamente invasiva (MISS) en desviaciones horizontales (DH). Metodo Serie de los primeros 26 casos consecutivos operados de estrabismo horizontal en nuestro hospital mediante MISS desde febrero de 2010 a marzo de 2014. Resultados Se incluyeron 40 ojos: 26 pacientes (edad media: 7,7 anos [DS: 4,9]; 34,61%: hombres). Se operaron 43 musculos: 20 rectos medios y 23 rectos laterales; 28 recesiones (rango: 3-7,5 mm), 6 resecciones (rango: 6-7 mm) y 9 plegamientos (rango: 6,5-7,5 mm). Se encontraron diferencias estadisticamente significativas (p 0,05) en la AV al dia siguiente de la cirugia y a los 6 meses. Un 29,27% de los ojos presento hiperemia leve, 48,78% moderada y 21,95% severa al primer dia postoperatorio, pasando al cuarto dia al 63,41%, 31,70% y 4,87% respectivamente. Las complicaciones fueron 4 casos de sangrado conjuntival intraoperatorio, una perforacion escleral y 2 prolapsos de Tenon. En un caso hubo que reconvertir a incision fornix por mala visualizacion. El rango del tiempo quirurgico disminuyo desde 30 a 15 min por musculo. Conclusiones La MISS ha obtenido buenos resultados en la cirugia del estrabismo horizontal. La inflamacion conjuntival es leve en la mayoria de los casos a los 4 dias de la cirugia. La AV se mantiene estable y el tiempo quirurgico va disminuyendo una vez superada la curva de aprendizaje de 4 anos.
Published: 2016
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142. Combinations of early generation antibiotics and antimicrobial peptides are effective against a broad spectrum of bacterial biothreat agents

Author: Susan L. Welkos, Melissa G. Hunter, Rekha G. Panchal, Christopher P. Klimko, Christopher K. Cote, Jennifer L. Shoe, and Irma I. Blanco
Subjects: 0301 basic medicine, Melioidosis, Burkholderia pseudomallei, 030106 microbiology, Glanders, Tigecycline, Biology, medicine.disease, Antimicrobial, biology.organism_classification, Microbiology, Bacillus anthracis, 03 medical and health sciences, Burkholderia mallei, 030104 developmental biology, Infectious Diseases, medicine, bacteria, Francisella tularensis, medicine.drug
Abstract: The misuse of infectious disease pathogens as agents of deliberate attack on civilians and military personnel is a serious national security concern, which is exacerbated by the emergence of natural or genetically engineered multidrug resistant strains. In this study, the therapeutic potential of combinations of an antibiotic and a broad-spectrum antimicrobial peptide (AMP) was evaluated against five bacterial biothreats, the etiologic agents of glanders (Burkholderia mallei), melioidosis (Burkholderia pseudomallei), plague (Yersinia pestis), tularemia (Francisella tularensis), and anthrax (Bacillus anthracis). The therapeutics included licensed early generation antibiotics which are now rarely used. Three antibiotics and one 24- amino acid AMP were selected based on MIC assay data. Combinations of the AMP and tigecycline, minocycline, or novobiocin were screened for synergistic activity by checkerboard MIC assay. The combinations each enhanced the susceptibility of several strains. The tetracycline-peptide combinations increased the sensitivities of Y. pestis, F. tularensis, B. anthracis and B. pseudomallei, and the novobiocin-AMP combination augmented the sensitivity of all five. In time-kill assays, down-selected combinations of the peptide and minocycline or tigecycline enhanced killing of B. anthracis, Y. pestis, F. tularensis, and Burkholderia mallei but not B. pseudomallei. The novobiocin-AMP pair significantly reduced viability of all strains except B. mallei, which was very sensitive to the antibiotic alone. The results suggested that antibiotic-AMP combinations are useful tools for combating diverse pathogens. Future studies employing cell culture and animal models will utilize virulent strains of the agents to investigate the in vivo availability, host cytotoxicity, and protective efficacy of these therapeutics.
Published: 2020
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143. Sa1703 USEFULNESS OF THE LONDON CLASSIFICATION FOR THE DIFFERENTIATION OF ANORECTAL FUNCTION DISORDERS IN PATIENTS WITH CHRONIC CONSTIPATION AND FECAL INCONTINENCE

Author: Yolanda Zamorano-Orozco, Claudia I. Blanco Vela, Flor de María, Nereo G. Salas Lozano, Edgardo Suárez Morán, Juana Donají Martínez Cortés, Mariel Alexandra Suárez Jáquez, Montes de Oca Salinas, and José I. Minero Alfaro
Subjects: Chronic constipation, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Anorectal function, Fecal incontinence, In patient, medicine.symptom, business
Published: 2020
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144. Sa1697 CHANGES IN ANORECTAL FUNCTION IN PATIENTS WITH SOILING VS FECAL INCONTINENCE

Author: Nereo G. Salas Lozano, Edgardo Suárez Morán, Juana Donají Martínez Cortés, Montes de Oca Salinas, José I. Minero Alfaro, Flor de María, Yolanda Zamorano-Orozco, Claudia I. Blanco Vela, and Mariel Alexandra Suárez Jáquez
Subjects: medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Urology, Medicine, Fecal incontinence, Anorectal function, In patient, medicine.symptom, business
Published: 2020
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145. Prognostic Nutritional Index predicts morbidity after curative surgery for colorectal cancer

Author: Rosalía Velasco-López, Javier Sánchez-González, Baltasar Perez-Saborido, José C. Sarmentero-Prieto, Martín Bailón-Cuadrado, Mario Rodríguez-López, José I. Blanco-Álvarez, and D. Pacheco-Sanchez
Subjects: Male, medicine.medical_specialty, Multivariate analysis, Colorectal cancer, Protective factor, Anorexia, 030230 surgery, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Internal medicine, medicine, Humans, Prospective Studies, Aged, Inflammation, business.industry, General Engineering, Cancer, medicine.disease, Prognosis, Predictive factor, Nutrition Assessment, Curative surgery, Female, medicine.symptom, Morbidity, business, Colorectal Neoplasms, Cohort study
Abstract: Introduction Colorectal cancer (CRC) is a major health concern and it is associated with significant morbidity and mortality. Over the last decades, the relationship between cancer and nutritional and inflammatory status in oncologic patients was studied thoroughly and multiple immunonutritional scores were developed. These scores have been mainly related to the prognosis of several cancers. An interaction between the tumour and the host is generated, triggering a systemic inflammatory reaction leading to several neuroendocrine changes. This situation favours a tendency towards anorexia and catabolism. Our hypothesis is that nutritional and inflammatory status of oncologic patients is correlated to postoperative morbidity. Methods This is a prospective observational cohort study with those patients undergoing curative surgery for CRC at our institution between September 2015 and March 2017. Nutritional and inflammatory status was established using Onodera's Prognostic Nutritional Index (PNI). Complications (overall, severe, infectious and anastomotic leakage) were carefully collected during the first 30 days of the postoperative period. Results After carrying out the multivariate analysis, PNI turned out to be a great predictive and protective factor for overall complications (RR: 0.279; 95% CI: 0.141–0.552), severe complications (RR: 0.355; 95% CI: 0.130–0.965), infectious complications (RR: 0.220; 95% CI: 0.099–0.489) and anastomotic leakage (RR: 0.151; 95% CI: 0.036–0.640). Conclusion Our work reports that PNI is an independent predictive factor for the development of postoperative complications following curative surgery for CRC.
Published: 2018

146. Heat fluxes in green walls

Author: I. Blanco, G. Scarascia Mugnozza, Evelia Schettini, G. Vox, Vox, G., Scarascia Mugnozza, G., Blanco, I., and Schettini, E.
Subjects: Evapotranspiration, 020209 energy, 0202 electrical engineering, electronic engineering, information engineering, Solar radiation, Environmental science, 02 engineering and technology, Horticulture, Energy modelling, Atmospheric sciences
Abstract: Increasing urban green infrastructure (UGI) in a city contributes to improve urban air quality and urban climate in summer, reducing buildings surface temperature, especially in southern Europe. UGI includes green walls and their correct application requires the knowledge of the energy performance of the applied green system. The effects of the green walls application on the building depend on the local climate, water availability, building shape. The presence of green walls affects the building microclimate all day, by reducing heat waves during the warm periods and heat losses from the building in cold periods. The heat and mass transfer between the external environment, the green wall and the building surface determine the building microclimate. Solar radiation, long wave infrared radiation, convective heat transfer and evapotranspiration are the main mechanism of heat transfer in a green wall. The paper describes the main parameters concerning heat flow in green walls that can be used in simulation models for predicting temperatures in buildings using the external weather conditions as model inputs. The green wall system was described by a schematic representation, the following layers were defined: the green wall, the gap air, the external surface of the building wall, the internal surface of the building wall, the air inside the building. The energy balance was defined for each layer and all the terms involved in the energy exchange between the layers were defined.
Published: 2018

147. Green façades to enhance climate control inside buildings

Author: Evelia Schettini, G. Vox, Carlo Alberto Campiotti, I. Blanco, Campiotti, C. A., Schettini, E., Blanco, I., and Vox, G.
Subjects: business.industry, 020209 energy, Urban heat island, Environmental engineering, Microclimate, Air-conditioning, 02 engineering and technology, Horticulture, Green walls, Urban agriculture, Thermal insulation, Air conditioning, Energy saving, Evapotranspiration, 0202 electrical engineering, electronic engineering, information engineering, Environmental science, Retrofitting, Daylight, business, Thermal energy, Green wall
Abstract: Green technology can represent a sustainable solution for construction of new buildings and for retrofitting of existing buildings, in order to reduce the energy demands of the buildings’ cooling systems, to mitigate the urban heat island and to improve the thermal energy performance of buildings. Green walls can allow the physical shading of the building, promote evapotranspiration in summer and increase thermal insulation in winter. An experimental test was carried out at the University of Bari (Italy) for 2 years. Three vertical walls, made with perforated bricks, were tested: two were covered with evergreen plants (Pandorea jasminoides and Rhyncospermum jasminoides), while the third wall was kept uncovered and used as a control. Several climatic parameters concerning the walls and the ambient conditions were collected during the experimental test. Daylight temperatures observed on the shielded walls during warm days were lower than the respective temperatures of the uncovered wall by up to 9.0°C. Night-time temperatures during cold days for the vegetated walls were higher than the respective temperatures of the control wall by up to 6.0°C. The absence in the literature of data concerning different seasons of the year is overcome in order to obtain a complete picture of building thermal performance in the Mediterranean climate region. © 2018 International Society for Horticultural Science. All Rights Reserved.
Published: 2018
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148. Double hepatic metastasis of double colon neoplasia: Adenocarcinoma and neuroendocrine tumour

Author: Francisco J, Tejero-Pintor, José C, Sarmentero-Prieto, Martín, Bailón-Cuadrado, José I, Blanco-Álvarez, Javier, Sánchez-González, Rosalía, Velasco-López, Paloma, Rodriguez-Vielba, and David, Pacheco-Sánchez
Subjects: Neoplasms, Multiple Primary, Neuroendocrine Tumors, Colonic Neoplasms, Liver Neoplasms, Hepatectomy, Humans, Anemia, Female, Cecal Neoplasms, Adenocarcinoma, Gastrointestinal Hemorrhage, Colectomy, Aged
Published: 2019
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149. Doble metástasis hepática de doble neoplasia de colon: adenocarcinoma y tumor neuroendocrino

Author: Francisco J. Tejero-Pintor, Javier Sánchez-González, Rosalía Velasco-López, José I. Blanco-Álvarez, Martín Bailón-Cuadrado, D. Pacheco-Sanchez, Paloma Rodriguez-Vielba, and José C. Sarmentero-Prieto
Subjects: medicine.medical_specialty, Hepatology, business.industry, medicine.medical_treatment, Internal medicine, Gastroenterology, medicine, Adenocarcinoma, medicine.disease, business, Colectomy, Metastasis
Published: 2019
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150. Cervicothoracic abscess secondary to transesophageal ultrasound-guided fine needle aspiration

Author: Francisco J. Tejero-Pintor, José I. Blanco-Álvarez, Martín Bailón-Cuadrado, and Mario Rodríguez-López
Subjects: medicine.medical_specialty, Fine-needle aspiration, medicine.diagnostic_test, business.industry, medicine, Radiology, Abscess, medicine.disease, business, Ultrasound guided
Published: 2019
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