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Se describe una nueva especie de alacrán, Diplocentrus leptomanus sp. nov., proveniente de la región noreste del estado de Sonora, México. Con este aporte, se eleva a cinco el número de especies del género Diplocentrus presentes en el estado y a dos el número de especies endémicas en el área. Se provee una diagnosis comparativa con Diplocentrus williamsi Sissom & Wheeler, 1995, Diplocentrus peloncillensis Francke, 1975 y Diplocentrus spitzeri Stahnke, 1970, especies con las que guarda cercanía morfológica y geográfica.

Long-acting injectables are a unique drug formulation strategy, providing a slow and sustained release of active pharmaceutical ingredients (APIs). In this study, a novel approach that combines liquid antisolvent precipitation with seeding to obtain a stable form of the API indomethacin while achieving the desired particle size distribution is described. It was proven that when a metastable form of indomethacin was initially nucleated, the rate of its transformation to the stable form was influenced by the presence of excipients and seeds (17.10 ± 0.20 μm), decreasing from 48 to 4 h. The final particle size (D50) of the indomethacin suspension produced without seeding was 7.33 ± 0.38 μm, and with seeding, it was 5.61 ± 0.14 μm. Additionally, it was shown that the particle size distribution of the seeds and the time point of seed addition were critical to obtain the desired solid-state form and that excipients played a crucial role during nucleation and polymorphic transformation. This alternative, energy-efficient bottom-up method for the production of drug suspensions with a reduced risk of contamination from milling equipment and fewer processing steps may prove to be comparable in terms of stability and particle size distribution to current industrially accepted top-down approaches.

Nas últimas décadas, podemos verificar uma tendência em diversos países de regulamentar o uso medicinal e recreativo da cannabis, o que pode gerar um enorme mercado global. No entanto, o histórico de quase um século na condição de ilegalidade, em praticamente todo o planeta, contribui para que a literatura científica sobre o tema seja severamente limitada. Partindo dessa problemática, o objetivo deste artigo é apresentar um modelo computacional, utilizando a linguagem Python e empregando técnicas de clusterização, tais como KMeans, Agglomerative Clustering e Spectral Clustering, de modo a encontrar grupos de interesse numa massa de dados. A base de dados utilizada foi obtida da aplicação do questionário do teste CUDIT – Cannabis Use Disorder Identification Test, composto de oito perguntas com cinco opções de resposta, que permitiram graduar o comportamento do indivíduo em cada questão. Os resultados demonstraram que a técnica foi capaz de separar grupos com padrões distintos e que apresentam consistência em análise qualitativa preliminar.

grandes transformações nas estruturas e nos processos organizacionais, gerando valores compatíveis com as novas demandas para o mercado global. Essas mudanças são observadas nos diferentes níveis e interferem na estrutura dos espaços produtivos, contribuindo para a definição de novas estratégias e novos modelos de negócios. Este trabalho tem como objetivo apresentar um estudo sobre o tema inovação e suas contribuições para o planejamento e gestão empresarial. Propõe a análise das principais teorias que definem os modelos de negócio, compreendendo a importância das diferentes tecnologias que promovem mudanças disruptivas em ambientes organizacionais altamente competitivos. Colabora para a construção de uma visão que fortalece a mentalidade empreendedora para a inovação tecnológica. A revisão bibliográfica contribui para a análise dos diferentes fatores que interferem na construção de um ambiente favorável ao plano de negócios e o desenvolvimento de modelos mentais para a mudança da cultura organizacional.

The aim of this review is to summarize the current scientific knowledge about acceleration and deceleration demands during football training.A systematic search of three electronic databases (PubMed, SPORTDiscus, Web of Science) was performed to identify peer-reviewed relevant English-language articles, following PRISMA guidelines.All acceleration and deceleration data were analyzed and organized into four categories: i) training drills variables (i.e. manipulated drills variables such as number of players in small-sided games), ii) training exercises (i.e. different drills such small games or circuit training), iii) players' positions (i.e. demands for each playing position) and iv) training schedule (i.e. training sessions presented as microcycles, season sections or full season). Full-text articles of 42 studies were included in the final analysis. Players' level included: amateur, youth, semi-professional, professional and elite players. All playing positions were considered, including goalkeepers. Six different global position systems brands were used, with the majority measuring data at 10 Hz. Different thresholds and intensities were used in several papers. Lower acceleration and deceleration intensities occurred more often than higher intensities in all four categories.Different exercises elicit different demands and small-sided games presented higher acceleration and deceleration demands than circuit training and other running based drills. Furthermore, manipulating drills variables, as reducing or increasing number of players in small-sided games increase or decrease demands, respectively. Additionally, wide playing positions, such as fullbacks, are generally exposed to higher acceleration and deceleration demands. From a planning point of view, acceleration and deceleration demands decrease as match day approaches.

To demonstrate the efficacy of the vacuum pressure impregnation (VPI) with commercial wood preservative products to eliminate the quarantine organism, pinewood nematode (PWN), Bursaphelenchus xylophilus, and other nematodes from maritime pine (Pinus pinaster) wood, in vitro assays and industrial assays in horizontal industrial autoclave tanks were conducted. In vitro nematicidal activity assays through direct exposure of the PWN 3rd-stage dispersal juveniles, the resistance juvenile stage, extracted from naturally infected P. pinaster revealed 100% nematode mortality with three commercial wood preservatives. Nematode mortality was also assessed in VPI industrial assays with the three commercial wood preservatives using naturally PWN infected P. pinaster experimental units, with various diameters and sizes. After VPI treatment, the nematode mortality ranged from 99.9761 to 100%. After incubation, the mortality of the total number of nematodes increased and, in all sections, the nematode mortality was higher than 99.9981% and in some it was 100% indicating that wood impregnated with preservative products does not constitute an environment favorable to the reproduction and development of nematodes. Overall, our findings demonstrated that the efficiency of the VPI process results from the joint action of the physical effect of pressure and vacuum and of the nematicidal effect of the preservative product. VPI treatment can be considered a valuable approach to eliminate PWN and other nematodes from maritime pine wood avoiding the subsequent application of the heat treatment.

Objetivo: O presente estudo objetiva relacionar aspectos positivos e negativos do enfermeiro gerente de unidade básica de saúde e que influenciam na gestão do cuidado. Métodos: Trata-se de uma pesquisa transversal, de abordagem qualitativa e caráter descritivo, realizada no período entre novembro de 2019 a janeiro de 2020. Resultados: Os enfermeiros gestores entrevistados compreenderam maioria do sexo feminino, casada, com especialização, caracterizados por formação profissional, atuação e gestão de unidade básica de saúde há mais de 4 anos. O duplo papel desempenhado influencia em desafios, possibilidades, motivação, benefícios e relação entre a comparação de atendimentos de enfermeiros gerentes e não gerentes. Conclusão: É importante destacar variáveis do processo de trabalho do enfermeiro gestor e do cuidado, através das múltiplas atribuições, mas compreendendo que para além dos desafios enfrentados, os mesmos apontam aspectos positivos e motivacionais com resposta a uma gestão participativa e de qualidade buscando pela melhor assistência à população.

Objective: The focus was prevention of enteroparasitic diseases in the school scenario, having as target audience the students of the institution, since many children did not have adequate hygiene habits, transforming the school into a favorable environment for the transmission of infectious and parasitary diseases. Methodology: Descriptive study of the experience report type, based on the problematization methodology of the Maguerez Arch, which aims to describe the experience of nursing students during a health education action carried out in a public school, in periphery of Belém-PA. Results and Discussion: Among the results achieved, they learning about the main diseases that can be transmitted in the school environment, as well as the preventive measures that can be adopted in their daily lives. Final Considerations: It is concluded that the action achieved its objectives, as it stimulated the adoption of healthy habits by the students and allowed the undergrad students to contribute to the promotion of health beyond the walls of the university, as recommend on their professional formation highlighting the relevance of actions like this.

Introduction: Genetic counseling (GC) has become a pivotal health service to manage high-risk patients with hereditary cancer. Brazil is a continental country with an admixture population that is suggested to have a high internal genetic variation. Here we describe the impact of GC in an underdeveloped area of Brazil which offered GC for hereditary cancer for the past 10 years. Methods: Retrospective cohort study with patients seen at the CG service from 2009 to 2019. All patients have undergone genetic testing and Hospital Anxiety and Depression Scale (HADS) was applied to assess psychological symptoms after genetic testing. Associations between variables were verified using Fisher's Exact Test, and survival analysis was estimated by Kaplan–Meier. Results: The GC service has included 139 patients, where 89.3% of patients had less than 60y, 63.3% had high-school graduate only, 91% had breast cancer as a primary diagnosis and 23.7% carries a germline pathogenic variant (PV) in high-risk genes. The 5 years overall survival was 88.6%, with no significant difference between patients with germline mutation (95% CI, p= 0.138). After GC, 68.7% and 55.6% of the patients had a normal score for depression and anxiety, respectively, regardless of age at diagnosis. Moreover, the decision of undergoing risk-reducing mastectomy (RRM) was not influenced by depressive or anxious symptoms, but by age, where 44% of women aged more than 60y did not present a willingness to undergo RRM. Among patients with PV, 91.7% could understand the meaning of germline mutation and the implications to health and 58% stated that the diagnosis of PV stimulated to modification of unhealthy habits. Low education level was significantly related to a limited understanding of the impact of carrying a PV. Conclusion: These results reflect the positive impact of GC in an underserved region of Brazil and highlight the importance of communicating with patients with low education levels.

Muitas crianças não conhecem o sistema de produção agrícola em função de viverem na cidade. Portanto, permitir o contato dessas crianças com os diversos sistemas de produção da cadeia de alimentos é proporcionar novas experiências e novos conceitos. O objetivo deste trabalho foi esclarecer às crianças como é o funcionamento do sistema de produção de alimentos, desde sua implantação no campo até o consumidor final. O projeto contou com a participação de 10 escolas e 150 crianças com faixa etária variando de 5 a 14 anos do município de Lavras. Por meio das metodologias qualitativas foi possível avaliar o impacto da visita na vida das crianças, dos pais e dos professores. A atividade foi desenvolvida no Departamento de Agricultura da Universidade Federal de Lavras, envolvendo setores de fruticultura, olericultura, cafeicultura e entomologia. Concluiu-se que a experiência teve impacto positivo na vida das crianças, pais e professores, mostrando que a exposição de crianças a experiências diferenciadas beneficia ainda mais a educação infantil.

Rigid particle models based on the discrete element method (DEM) have been adopted to model creep, fracture, and the viscoelastic behaviour of asphalt mixtures considering an irregular micro-structure and particle contacts. Within a DEM framework, the Burgers contact model, which is known to have a narrow frequency and temperature range, is usually adopted to model viscoelastic properties. In this study, a new explicit three-dimensional generalised Kelvin (GK) contact model formulation for the DEM model is proposed for asphalt materials. The model is implemented following two different methodologies (GK (Formula presented.) and GK (Formula presented.)). The models are validated in uniaxial tension-compression sinusoidal tests for predicting the dynamic modulus ((Formula presented.)) and phase angle (ϕ) of these composites at a frequency range of 1–10 Hz at (Formula presented.) C. Four mixtures are investigated based on the modelling of their mastic. The influence of the GK contact parameters on the dynamic response of mastics is assessed. Results show that (Formula presented.) has an important influence on both rheological properties and that (Formula presented.) can be used for small adjustments focussing on the predicted phase angle. Moreover, it is shown that a viscoelastic contact model should be adopted to simulate aggregate-to-mastic contacts in mixtures. As expected, the response obtained for both GK models is the same but the simulations with the GK (Formula presented.) are 14% faster. In addition, the response predicted with the proposed GK contact model is compared with the response predicted with a Burgers contact model. The DEM predictions obtained for the GK model are more accurate. For mastics, the average errors for (Formula presented.) and ϕ when adopting the GK model (Burgers) are 2.40% (3.46%) and 3.64% (4.17%), respectively. For mixtures, the average errors for (Formula presented.) for the GK model (Burgers) are 7.00% (7.92%). The proposed contact model greatly enhances the DEM ability to simulate the viscoelasticity of asphalt materials., This work is part of the research activity carried out at Civil Engineering Research and Innovation for Sustainability (CERIS) and has been funded by Fundacao para a Ciencia e a Tecnologia (FCT) in the framework of [project number UIDB/04625/2020].

A pesquisa operacional (PO) é um instrumento de tomada de decisão muito respeitável devido a sua forma lógica de decorrer. O alvo é mostrar a seriedade da PO para a tomada racional de decisão, como usar o recurso Solver no Excel, e como chegar ao saldo de maximização em apontado processo de fabricação de discos de algodão em uma empresa do ramo de algodão hidrófilo. Foi utilizado diferentes bibliografias para o alicerce teórico do trabalho, também utilizamos de cronometragem de processos na empresa e o programa Microsoft Office Excel para a resolução do problema de maximização do processo. Como resultados, notou-se que todos os processos estão atingindo o seu limite de caixas. Essa realidade demonstra a necessidade de um estudo direcionado e focado na otimização e maximização da produção do item Disco.

Quando as empresas ou marcas desejam se apresentar ao mercado, é incontestável a necessidade de se criar ferramentas de marketing para se garantir a satisfação dos clientes, sobretudo diante de um mercado tão interligado, competitivo e profissional. É nesse mercado que as empresas de café se mostram. Assim, o objetivo desse estudo é o de lançar no mercado o Quiriquiri Café, em Piranhas-AL, buscando ampliar o mercado, expandindo das limitações de Paulo Afonso-BA e ganhando espaço em outros locais da região Nordeste. O local e o período de lançamento se justificam pela pesquisa exploratória e descritiva de análise de cenário que foi realizada, bem como a utilização do Google Trends, com triangulação de informações entre o período da alta estação e da reserva de hóspedes do Pedra do Sino Hotel. Até aqui, os resultados são satisfatórios em relação a vendas e apontaram grau de surpresa por parte dos hóspedes e inovação por parte dos proprietários, que perceberam a importância do feito. Com isso, espera-se que, ao longo de sua permanência em Piranhas-AL, advenham outras ocasiões de parcerias e comercialização do Quiriquiri Café, gerando oportunidades de novos negócios.