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Objective: This study aimed to analyze myocardial work in patients with atrial fibrillation (AF) using a noninvasive pressure strain loop (PSL) technique to provide a basis for the quantitative assessment of left ventricular (LV) systolic function. Methods: LV myocardial work of 107 AF patients (56 with paroxysmal atrial fibrillation and 51 with persistent atrial fibrillation) and 55 healthy individuals were assessed by the noninvasive PSL and then compared. Results: Global longitudinal strain (GLS) in absolute values, global work index (GWI), global constructive work (GCW), and global work efficiency (GWE) were significantly lower in the AF group than control group, whereas peak strain dispersion (PSD) and global wasted work (GWW) were significantly higher (P <.05). Further subdivision according to the AF type revealed that, compared with the controls, GLS in absolute values and GWE decreased significantly; PSD and GWW increased significantly in the paroxysmal AF group (P <.05). Nevertheless, GWI and GCW were not significantly different between paroxysmal AF and control groups (P >.05). Compared to paroxysmal AF, persistent AF induced a further decrease in absolute GLS and GWE and a further increase in GWW (P <.05), but PSD did not increase further (P >.05). Multiple linear regression analysis showed that GWI and GCW were independently associated with systolic blood pressure. GWW was associated with types of AF and left atrial volume index (LAVI). GWE was correlated with age, types of AF, disease duration, and LAVI. Receiver operating characteristic curve analysis showed that the area under the curve predicting myocardial injury was higher for GWE and GWW than for GLS (area under the curve:.880,.846, and.821, respectively). Conclusions: Non‐invasive PSL can quantitatively assess LV systolic function in patients with different kinds of AF and detect early subclinical myocardial injury in patients with paroxysmal AF. GWE and GWW outperform GLS and LV ejection fraction when assessing myocardial injury. Systolic blood pressure, type of AF, LVAI, disease duration, and age may be associated with myocardial injury in patients with AF. [ABSTRACT FROM AUTHOR]

The intervention process for children with autism spectrum disorder (ASD) is inextricably associated with their parents' mental health problems, such as hopelessness, which may adversely affect resilience and indirectly impact the effectiveness of interventions for their children. Hence, the motivation to help parents of children with ASD reduce hopelessness prompted us to conduct the present study and explore the interrelationship between hopelessness symptoms and resilience. This study evaluated hopelessness and resilience using the Beck Hopelessness Scale (BHS) and the Connor–Davidson Resilience Scale (CD‐RISC). Participants met the criteria for their children's ASD diagnosis by a psychiatrist (N = 448; 54.69% mothers; Meanage = 34.59 years, SDage = 4.94 years). Moreover, we used symptom network analysis to examine the variability in network structure between fathers and mothers. The flow function was applied to examine which hopelessness symptoms were directly or indirectly associated with resilience. The results showed that #BHS11 (i.e., unpleasantness‐ahead) was the central symptom found in the network structure for all parents and fathers, while #BHS17 (i.e., no‐future‐satisfaction) was the central symptom in the network structure for mothers. Additionally, #BHS6 ([NOT] expect‐to‐succeed) was directly and positively associated with resilience in all three network structures (i.e., all parents, fathers, and mothers). The results of the present study provide evidence that influential symptoms should be addressed and offer guidance for further interventions to reduce hopelessness and enhance resilience among parents of children with ASD. [ABSTRACT FROM AUTHOR]

Typical (peridinin-containing) dinoflagellates possess plastid genomes composed of small plasmids named "minicircles". Despite the ecological importance of dinoflagellate photosynthesis in corals and marine ecosystems, the structural characteristics, replication dynamics, and evolutionary forcing of dinoflagellate plastid genomes remain poorly understood. Here, we sequenced the plastid genome of the symbiodiniacean species Fugacium kawagutii and conducted comparative analyses. We identified psbT -coding minicircles, features previously not found in Symbiodiniaceae. The copy number of F. kawagutii minicircles showed a strong diel dynamics, changing between 3.89 and 34.3 copies/cell and peaking in mid-light period. We found that F. kawagutii minicircles are the shortest among all dinoflagellates examined to date. Besides, the core regions of the minicircles are highly conserved within genus in Symbiodiniaceae. Furthermore, the codon usage bias of the plastid genomes in Heterocapsaceae, Amphidiniaceae, and Prorocentraceae species are greatly influenced by selection pressure, and in Pyrocystaceae, Symbiodiniaceae, Peridiniaceae, and Ceratiaceae species are influenced by both natural selection pressure and mutation pressure, indicating a family-level distinction in codon usage evolution in dinoflagellates. Phylogenetic analysis using 12 plastid-encoded proteins and five nucleus-encoded plastid proteins revealed accelerated evolution trend of both plastid- and nucleus-encoded plastid proteins in peridinin- and fucoxanthin-dinoflagellate plastids compared to plastid proteins of nondinoflagellate algae. These findings shed new light on the structure and evolution of plastid genomes in dinoflagellates, which will facilitate further studies on the evolutionary forcing and function of the diverse dinoflagellate plastids. The accelerated evolution documented here suggests plastid-encoded sequences are potentially useful for resolving closely related dinoflagellates. [ABSTRACT FROM AUTHOR]

It is difficult to optimize flexibility robustness because the robust optimization of multiple response for cell injection 3 RRR compliant parallel micro motion platform flexible parts are existed"under"deformation or"over"deformation. a new method is proposed to solve the robust optimization of multiple response which combine the Taguchi method and satisfaction function. Firstly,the hinge motion model compliance of micro-platform multi-directional is established and the response surface test design based on this model. Secondly,the taguchi method is introduced to analyze the stability of multiple response. Finally,the satisfaction function is used to taken the issues of multiple response optimization into maximal value of overall satisfaction and get the robust optimization design plan under the restriction of multiple response flexibility. Examples show that this method can provide a new solution for robust optimal design of the multiple response of flexible hinge.

The present lithium‐ion battery technology competition almost focuses on finding new materials, while less effort is invested in electrode engineering improvement with low‐cost. This study proposes a simple method of modulating the preferred orientation of crystal phases in LiCoO2 electrode using a ≈500 mT magnetic‐field, cheaply and efficiently improving the performance of LiCoO2||graphite pouch full batteries, including cycling stability, rate performance, and thermal safety performance. Under 3.0 C and 45 °C strict test conditions, LiCoO2‐M⊥||graphite battery even outputs the capacity retention rate of 42.8% after 1000 cycles, while that of pure‐LiCoO2 battery is only 4.4%. Especially, the thermal runaway temperature of the battery needling experiment decreases by considerable 7.7 °C after magnetic‐field modulation. Comprehensive characterizations reveal that vertical magnetic field causes spin alignment of LiCoO2 crystals along the (003) direction. This arrangement effectively improves the Li+ diffusion dynamic and the interface compatibility of the electrode, suppressing the electrode polarization. During the cycling processes, the preferred orientation of LiCoO2 particles forms an enhanced conductive network due to the formation of cross‐linked "Li+ poor regions" on the surface, ultimately achieving significant performance improvement. This work can provide a potential low‐cost strategy for the production of commercial lithium‐ion batteries. [ABSTRACT FROM AUTHOR]

Objective: To investigate the role of hepatocyte growth factor and its receptor c-Met (HGF/ c-Met) signaling pathway in early follicular development in mice via detecting the expression of HGF/c-Met in early mouse ovarian tissue and then analyze the biological process of HGF/c-Met signaling pathway and its possible involvement in intracellular signaling pathways by using bioinformatics for the purpose of further studying the molecular mechanism of the signaling pathway in the early follicle development. Methods. Thirty-five female Kunming mice and 15 male ones were fed in 15 cages with the female-to-male ratio of 2,1. The ovaries of mice at 3, 7, 14 and 21 days after birth were collected. Immunohistochemical staining and Western blotting were applied to detect the expression levels of HGF and c-Met protein in the ovarian tissues. Quantitative Real-time PCR,q-PCR, was used to detect the expression levels of HGF and C-Met mRNA in the early ovarian tissues of mice. Results, HGF and c-Met proteins were expressed in the ovarian tissues of the mice at 3, 7, 14 and 21 days, presenting an increasing trend with the increase of age by day,P < 0.05,. The mRNA levels of HGF and c-Met also showed the same trend,P < 0.05,. Bioinformatics analysis revealed that the HGF/c-Met signaling pathway involved in a variety of biological processes and signaling pathways such as PI3K/AKT. Conclusions,HGF/c-Met signaling pathway is involved in early follicular development in mice. It may regulate primal follicular initiation and follicular develop, ment through intracellular signaling pathway PI3K/AKT. [ABSTRACT FROM AUTHOR]