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4,788 results on '"Huang, Qin"'

112. Influence of autozygosity on common disease risk across the phenotypic spectrum

Author

Malawsky, Daniel S., van Walree, Eva, Jacobs, Benjamin M., Heng, Teng Hiang, Huang, Qin Qin, Sabir, Ataf H., Rahman, Saadia, Sharif, Saghira Malik, Khan, Ahsan, Mirkov, Maša Umićević, Kuwahara, Hiroyuki, Gao, Xin, Alkuraya, Fowzan S., Posthuma, Danielle, Newman, William G., Griffiths, Christopher J., Mathur, Rohini, van Heel, David A., Finer, Sarah, O’Connell, Jared, and Martin, Hilary C.

Published
2023
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124. PIK3R3 is a candidate regulator of platelet count in people of Bangladeshi ancestry

Author

Akhtar, Shaheen, Anwar, Mohammad, Arciero, Elena, Asgar, Omar, Ashraf, Samina, Breen, Gerome, Chung, Raymond, Curtis, Charles J., Chaudhary, Shabana, Chowdhury, Maharun, Colligan, Grainne, Deloukas, Panos, Durham, Ceri, Durrani, Faiza, Eto, Fabiola, Finer, Sarah, Garcia, Ana Angel, Griffiths, Chris, Harvey, Joanne, Heng, Teng, Huang, Qin Qin, Hurles, Matt, Hunt, Karen A., Hussain, Shapna, Islam, Kamrul, Jacobs, Ben, Khan, Ahsan, Khan, Amara, Lavery, Cath, Lee, Sang Hyuck, Lerner, Robin, MacArthur, Daniel, Malawsky, Daniel, Martin, Hilary, Mason, Dan, Mazid, Mohammed Bodrul, McDermott, John, McSweeney, Sanam, Miah, Shefa, Munir, Sabrina, Newman, Bill, Owor, Elizabeth, Qureshi, Asma, Rahman, Samiha, Safa, Nishat, Solly, John, Tahmasebi, Farah, Trembath, Richard C., Tricker, Karen, Uddin, Nasir, van Heel, David A., Winckley, Caroline, Wright, John, Burley, Kate, Fitzgibbon, Lucy, van Heel, David, Vuckovic, Dragana, and Mumford, Andrew D.

Published
2023
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128. Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

Author

Chen, Ming-Huei, Raffield, Laura M, Mousas, Abdou, Sakaue, Saori, Huffman, Jennifer E, Moscati, Arden, Trivedi, Bhavi, Jiang, Tao, Akbari, Parsa, Vuckovic, Dragana, Bao, Erik L, Zhong, Xue, Manansala, Regina, Laplante, Véronique, Chen, Minhui, Lo, Ken Sin, Qian, Huijun, Lareau, Caleb A, Beaudoin, Mélissa, Hunt, Karen A, Akiyama, Masato, Bartz, Traci M, Ben-Shlomo, Yoav, Beswick, Andrew, Bork-Jensen, Jette, Bottinger, Erwin P, Brody, Jennifer A, van Rooij, Frank JA, Chitrala, Kumaraswamynaidu, Cho, Kelly, Choquet, Hélène, Correa, Adolfo, Danesh, John, Di Angelantonio, Emanuele, Dimou, Niki, Ding, Jingzhong, Elliott, Paul, Esko, Tõnu, Evans, Michele K, Floyd, James S, Broer, Linda, Grarup, Niels, Guo, Michael H, Greinacher, Andreas, Haessler, Jeff, Hansen, Torben, Howson, Joanna MM, Huang, Qin Qin, Huang, Wei, Jorgenson, Eric, Kacprowski, Tim, Kähönen, Mika, Kamatani, Yoichiro, Kanai, Masahiro, Karthikeyan, Savita, Koskeridis, Fotis, Lange, Leslie A, Lehtimäki, Terho, Lerch, Markus M, Linneberg, Allan, Liu, Yongmei, Lyytikäinen, Leo-Pekka, Manichaikul, Ani, Martin, Hilary C, Matsuda, Koichi, Mohlke, Karen L, Mononen, Nina, Murakami, Yoshinori, Nadkarni, Girish N, Nauck, Matthias, Nikus, Kjell, Ouwehand, Willem H, Pankratz, Nathan, Pedersen, Oluf, Preuss, Michael, Psaty, Bruce M, Raitakari, Olli T, Roberts, David J, Rich, Stephen S, Rodriguez, Benjamin AT, Rosen, Jonathan D, Rotter, Jerome I, Schubert, Petra, Spracklen, Cassandra N, Surendran, Praveen, Tang, Hua, Tardif, Jean-Claude, Trembath, Richard C, Ghanbari, Mohsen, Völker, Uwe, Völzke, Henry, Watkins, Nicholas A, Zonderman, Alan B, Program, VA Million Veteran, Wilson, Peter WF, Li, Yun, Butterworth, Adam S, Gauchat, Jean-François, Chiang, Charleston WK, and Li, Bingshan

Subjects
Genetics, Good Health and Well Being, Asian People, Genome-Wide Association Study, HEK293 Cells, Humans, Interleukin-7, Mutation, Missense, Phenotype, Polymorphism, Single Nucleotide, White People, VA Million Veteran Program, interleukin-7, genetic architecture, fine-mapping, selective sweeps, polygenic trait score, phenome-wide association study, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant associations at p < 5 × 10-9, including 71 novel associations not found in EUR populations. We also identified 28 additional novel variants in ancestry-specific, non-EUR meta-analyses, including an IL7 missense variant in South Asians associated with lymphocyte count in vivo and IL-7 secretion levels in vitro. Fine-mapping prioritized variants annotated as functional and generated 95% credible sets that were 30% smaller when using the trans-ethnic as opposed to the EUR-only results. We explored the clinical significance and predictive value of trans-ethnic variants in multiple populations and compared genetic architecture and the effect of natural selection on these blood phenotypes between populations. Altogether, our results for hematological traits highlight the value of a more global representation of populations in genetic studies.

Published
2020

129. Unsupervised Video Object Segmentation with Distractor-Aware Online Adaptation

Author

Wang, Ye, Choi, Jongmoo, Chen, Yueru, Li, Siyang, Huang, Qin, Zhang, Kaitai, Lee, Ming-Sui, and Kuo, C. -C. Jay

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Unsupervised video object segmentation is a crucial application in video analysis without knowing any prior information about the objects. It becomes tremendously challenging when multiple objects occur and interact in a given video clip. In this paper, a novel unsupervised video object segmentation approach via distractor-aware online adaptation (DOA) is proposed. DOA models spatial-temporal consistency in video sequences by capturing background dependencies from adjacent frames. Instance proposals are generated by the instance segmentation network for each frame and then selected by motion information as hard negatives if they exist and positives. To adopt high-quality hard negatives, the block matching algorithm is then applied to preceding frames to track the associated hard negatives. General negatives are also introduced in case that there are no hard negatives in the sequence and experiments demonstrate both kinds of negatives (distractors) are complementary. Finally, we conduct DOA using the positive, negative, and hard negative masks to update the foreground/background segmentation. The proposed approach achieves state-of-the-art results on two benchmark datasets, DAVIS 2016 and FBMS-59 datasets., Comment: 11 pages, 6 figures, 4 tables, conference

Published
2018

130. Design Pseudo Ground Truth with Motion Cue for Unsupervised Video Object Segmentation

Author

Wang, Ye, Choi, Jongmoo, Chen, Yueru, Huang, Qin, Li, Siyang, Lee, Ming-Sui, and Kuo, C. -C. Jay

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

One major technique debt in video object segmentation is to label the object masks for training instances. As a result, we propose to prepare inexpensive, yet high quality pseudo ground truth corrected with motion cue for video object segmentation training. Our method conducts semantic segmentation using instance segmentation networks and, then, selects the segmented object of interest as the pseudo ground truth based on the motion information. Afterwards, the pseudo ground truth is exploited to finetune the pretrained objectness network to facilitate object segmentation in the remaining frames of the video. We show that the pseudo ground truth could effectively improve the segmentation performance. This straightforward unsupervised video object segmentation method is more efficient than existing methods. Experimental results on DAVIS and FBMS show that the proposed method outperforms state-of-the-art unsupervised segmentation methods on various benchmark datasets. And the category-agnostic pseudo ground truth has great potential to extend to multiple arbitrary object tracking., Comment: 16 pages, 7 figures, 6 tables, conference

Published
2018

131. Implementation and Security Analysis of Practical Quantum Secure Direct Communication

Author

Qi, Ruoyang, Sun, Zhen, Lin, Zaisheng, Niu, Penghao, Hao, Wentao, Song, Liyuan, Huang, Qin, Gao, Jiancun, Yin, Liuguo, and Long, Gui-Lu

Subjects
Quantum Physics
Abstract

Fast development of supercomputer and perspective quantum computer is posing increasing serious threats to communication security. Based on the laws of quantum mechanics, quantum communication offers provable security of communication, and is a promising solution to counter such threats. Quantum secure direct communication (QSDC) is one of the important branches of quantum communication. Different from other branches of quantum communication, it transmits secret information directly. Recently, remarkable progress has been made in the proof-of-principle experimental demonstrations of QSDC. However, it remains a technical feast to march QSDC into practical application. Here, we report an implementation of practical quantum secure communication system. The security is analyzed in the Wyner wiretap channel theory. The system uses a coding scheme based on concatenation of low density parity check (LDPC) codes, which works in a regime with realistic environment of high noise and high loss. The present system operates with a repetition rate of 1 MHz, and at a distance of 1.5 kilometers. The secure communication rate is 50 bps, which can effectively send text message and files such as image and sounds with a reasonable size., Comment: 14 pages, 4 figures

Published
2018

140. The combination of tumor mutational burden and T‐cell receptor repertoire predicts the response to immunotherapy in patients with advanced non–small cell lung cancer

Author

Li, Yalun, primary, Ji, Liyan, additional, Zhang, Yingqian, additional, Zhang, Jiexin, additional, Reuben, Alexandre, additional, Zeng, Hao, additional, Huang, Qin, additional, Wei, Qi, additional, Tan, Sihan, additional, Xia, Xuefeng, additional, Li, Weimin, additional, Zhang, Jianjun, additional, and Tian, Panwen, additional

Published
2024
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147. Deep learning assists detection of esophageal cancer and precursor lesions in a prospective, randomized controlled study

Author

Li, Shao-wei, primary, Zhang, Li-hui, additional, Cai, Yue, additional, Zhou, Xian-bin, additional, Fu, Xin-yu, additional, Song, Ya-qi, additional, Xu, Shi-wen, additional, Tang, Shen-ping, additional, Luo, Ren-quan, additional, Huang, Qin, additional, Yan, Ling-ling, additional, He, Sai-qin, additional, Zhang, Yu, additional, Wang, Jun, additional, Ge, Shu-qiong, additional, Gu, Bin-bin, additional, Peng, Jin-bang, additional, Wang, Yi, additional, Fang, Li-na, additional, Wu, Wei-dan, additional, Ye, Wen-guang, additional, Zhu, Min, additional, Luo, Ding-hai, additional, Jin, Xiu-xiu, additional, Yang, Hai-deng, additional, Zhou, Jing-jing, additional, Wang, Zhen-zhen, additional, Wu, Jian-fen, additional, Qin, Qiao-qiao, additional, Lu, Yan-di, additional, Wang, Fei, additional, Chen, Ya-hong, additional, Chen, Xia, additional, Xu, Shan-jing, additional, Tung, Tao-Hsin, additional, Luo, Chen-wen, additional, Ye, Li-ping, additional, Yu, Hong-gang, additional, and Mao, Xin-li, additional

Published
2024
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