Search

Your search keyword '"Huang, Dong-Sheng"' showing total 466 results
Start Over Author "Huang, Dong-Sheng"
466 results on '"Huang, Dong-Sheng"'

107. Survival benefits from adjuvant transcatheter arterial chemoembolization in patients undergoing liver resection for hepatocellular carcinoma: a systematic review and meta-analysis

Author

Liang, Lei, primary, Li, Chao, additional, Diao, Yong-Kang, additional, Jia, Hang-Dong, additional, Xing, Hao, additional, Pawlik, Timothy M., additional, Lau, Wan Yee, additional, Shen, Feng, additional, Huang, Dong-Sheng, additional, Zhang, Cheng-Wu, additional, and Yang, Tian, additional

Published
2020
Full Text
View/download PDF

111. MiR-200a inhibits cell proliferation and EMT by down-regulating the ASPH expression levels and affecting ERK and PI3K/Akt pathways in human hepatoma cells

Author

Yao, Wei-Feng, Liu, Jun-Wei, and Huang, Dong-Sheng

Subjects
Original Article
Abstract

The primary objective of this study was to investigate the role of miR-200a in cell proliferation and epithelial-mesenchymal transition (EMT) through regulating targeting aspartate-β-hydroxylase (ASPH), which may further affect the activation of ERK/PI3K/Akt pathway. Liver cancer and adjacent tissues were collected from 72 cases of liver cancer patients with surgery in our hospital. In this study, the mRNA expression level of miR-200a was significantly decreased by real-time PCR (RT-PCR) detection. ASPH expressions, however, had an opposite tendency compared to that of miR-200a. We found a significantly negative correlation between miR-200a expressions and ASPH expressions. The survival rate of liver cancer patients with the low expressed ASPH was significantly higher than those with the high expressed ASPH. RT-PCR and Western blot results showed that low expressed miR-200a and highexpressed ASPH were found in liver cancer cell lines. Further research discovered that miR-200a transfection could significantly decrease the relative luciferase activity when it was integrated with ASPH 3'-untranslated region (3'-UTR) in HepG2 cells. Cell Counting Kit (CCK-8) detection showed that treatment with miR-200a mimics reduced cell viability, while the over-expressed ASPH increased cell viability by regulating the c-mycmrna (c-Myc) and Cyclin-D1 expressions. The EMT-related genes including E-Cadherin, N-Cadherin and Vimentin expressions were significantly increased, whereas the over-expressed ASPH exerted the opposite effects. In addition, extracellular signal regulated kinase (ERK), phosphoinositide-3-kinase (PI3K) and serine threonine kinase (AKT) were suppressed by miR-200a mimics. In conclusion, miR-200a inhibits cell proliferation and EMT in human hepatoma cells by targeting ASPH and affecting ERK and PI3K/Akt signaling pathways.

Published
2018

113. Bacteria-Instructed Click Chemistry between Functionalized Gold Nanoparticles for Point-of-Care Microbial Detection

Author

Mou, Xiao-Zhou, primary, Chen, Xiao-Yi, additional, Wang, Jianhao, additional, Zhang, Zhaotian, additional, Yang, Yanmei, additional, Shou, Zhang-Xuan, additional, Tu, Yue-Xing, additional, Du, Xuancheng, additional, Wu, Chun, additional, Zhao, Yuan, additional, Qiu, Lin, additional, Jiang, Pengju, additional, Chen, Chunying, additional, Huang, Dong-Sheng, additional, and Li, Yong-Qiang, additional

Published
2019
Full Text
View/download PDF

115. Manufacture and process of high PS material

Author

ZHANG Jia-xiang, 张家祥, primary, WANG Wei, 王 威, additional, WANG Yan-qiang, 王彦强, additional, JIAO Yu, 焦 宇, additional, ZHOU Hai-long, 周海龙, additional, ZHANG Fang, 张 芳, additional, XU Shan-shan, 徐闪闪, additional, CHEN Zhao, 陈 召, additional, QIN Yi-feng, 覃一锋, additional, ZHANG Wen-yu, 张文余, additional, HUANG Dong-sheng, 黄东升, additional, and CHEN Si, 陈 思, additional

Published
2019
Full Text
View/download PDF

116. Parthenolide induces proliferation inhibition and apoptosis of pancreatic cancer cells in vitro

Author

Xie Hai-Yang, Yang Po, Ma Jun, Wu Qing-Song, Xin Ying, Cai Min-Xia, Liu Jun-Wei, and Huang Dong-Sheng

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background To explore the anti-tumor effects of parthenolide in human pancreatic cancer. Methods BxPC-3 cell, a human pancreatic cancer, was treated with parthenolide at different concentrations. The MTT assay was used to analyze cell viability. Flow cytometry and DNA fragmentation analysis were applied to evaluate apoptosis after parthenolide treatment. The wound closure and cell invasion assay were also employed in the study. Western blotting was used to demonstrate Bad, Bcl-2, Bax, caspase-9 and pro-caspase-3 expression. Results The MTT assay indicated that the pancreatic cancer growth could be dose-dependently inhibited by parthenoolide. This phenomenon was confirmed by flow cytometry and DNA fragmentation analysis. The wound closure assay and cell invasion assay showed that BxPC-3 cell was significantly suppressed by parthenolide at 7.5 μM and 15 μM. Western Blotting demonstrated the Bcl-2 and pro-caspase-3 were down-regulated while the Bax and caspase-9 were up-regulated. No alteration in Bad expression was found after treatment. Conclusions The parthenolide can inhibit the cell growth, migration, and induce the apoptosis in human pancreatic cancer. These findings may provide a novel approach for pancreatic cancer treatment.

Published
2010
Full Text
View/download PDF

118. Molecular Imaging of Cancer with Nanoparticle-Based Theranostic Probes

Author

Ma, Ying-Yu, Jin, Ke-Tao, Wang, Shi-Bing, Wang, Hui-Ju, Tong, Xiang-Min, Huang, Dong-Sheng, and Mou, Xiao-Zhou

Subjects
Article Subject
Abstract

Although advancements in medical technology supporting cancer diagnosis and treatment have improved survival, these technologies still have limitations. Recently, the application of noninvasive imaging for cancer diagnosis and therapy has become an indispensable component in clinical practice. However, current imaging contrasts and tracers, which are in widespread clinical use, have their intrinsic limitations and disadvantages. Nanotechnologies, which have improved in vivo detection and enhanced targeting efficiency for cancer, may overcome some of the limitations of cancer diagnosis and therapy. Theranostic nanoparticles have great potential as a therapeutic model, which possesses the ability of their nanoplatforms to load targeted molecule for both imaging and therapeutic functions. The resulting nanosystem will likely be critical with the growth of personalized medicine because of their diagnostic potential, effectiveness as a drug delivery vehicle, and ability to oversee patient response to therapy. In this review, we discuss the achievements of modern nanoparticles with the goal of accurate tumor imaging and effective treatment and discuss the future prospects.

Published
2017
Full Text
View/download PDF

119. Decreased DC-SIGNR expression in hepatocellular carcinoma predicts poor patient prognosis.

Author

Xia, Hai-Bing, Wang, Hui-Ju, Song, Shu-Shu, Zhang, Jun-Gang, He, Xiang-Lei, Hu, Zhi-Ming, Zhang, Cheng-Wu, Huang, Dong-Sheng, and Mou, Xiao-Zhou

Subjects
HEPATOCELLULAR carcinoma, CELL adhesion, IMMUNE recognition, POTENTIAL functions, PROTEIN expression
Abstract

Dendritic cell-specific intercellular adhesion molecule-grabbing non-integrin-related protein (DC-SIGNR) is a transmembrane receptor primarily involved in pathogen recognition by the innate immune system, with particular importance for viral recognition. DC-SIGNR may also be associated with tumorigenesis. The aim of the present study was to investigate the association between DC-SIGNR expression, development of hepatocellular carcinoma (HCC), and clinicopathological features. Immunohistochemistry was used to assess DC-SIGNR protein expression in HCC and paired non-cancerous tissue samples. DC-SIGNR expression was lower in HCC tissues compared with adjacent non-tumor tissue samples. The expression of DC-SIGNR was associated with small tumor size, low Edmondson grade and high patient long term survival rates. Bioinformatics analyses were performed on several datasets to assess the potential function of DC-SIGNR and related genes; the data revealed that DC-SIGNR mRNA expression was lower in HCC tissues compared with non-cancerous controls, and analyses of ten-year survival rates indicated patients with low DC-SIGNR expression exhibited shorter average survival times. In conclusion, decreased DC-SIGNR expression in HCC tissues may be a relevant predictive biomarker of clinical prognosis, in addition to being a viable therapeutic target for HCC treatment. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

122. Effects of array Mura by adjustment of etchant

Author

JI Xin-you, 冀新友, primary, ZHANG Jia-xiang, 张家祥, additional, WANG Liang, 王 亮, additional, ZHANG Jie, 张 洁, additional, LU Kai, 卢 凯, additional, HUANG Dong-sheng, 黄东升, additional, CHEN Si, 陈 思, additional, and WANG Wei, 王 威, additional

Published
2018
Full Text
View/download PDF

124. Analysis of Pinhol Defects on Alignment Layer Surface for TFT-LCD

Author

赵凯 Zhao Kai, 黄东升 Huang Dong-sheng, 张志男 Zhang Zhi-nan, 夏子祺 Xia Zi-qi, and 王威 Wang Wei

Subjects
Surface (mathematics), Materials science, Liquid-crystal display, business.industry, Pinhole, Instability, Electronic, Optical and Magnetic Materials, law.invention, Optics, Thin-film transistor, law, Signal Processing, Composite material, business, Instrumentation, Layer (electronics), Statistical software, Black spot
Abstract

The pinholes on the surface of alignment layer was studied, which formed during the TFT-LCD manufacturing process and caused defects of the products. Herein, a vitally typical defect, black spot, was analyzed via FIB, SEM and OMS. The analysis results of statistical software BO (Business Objects) show that the pinhole is the main cause of the blackspot. Based on theoretical analysis and further experimental results, it is found that the hydrodynamic in stability of the solution may lead to the pinholes on the alignment layer surface, and the precure time of the alignment film solution is significantly responsible for hydrodynamic instability. It is noteworthy that the instability needs times to grow full enoughand then to influence the film structure. Therefore, the pinholes on the alignment layer surface will be reduced or eliminated if the precure time is less than or equal to that time.

Published
2011

138. Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1

Author

Wu, Guo-Qing, primary, Chai, Ke-Qun, additional, Zhu, Xiu-Ming, additional, Jiang, Hua, additional, Wang, Xiao, additional, Xue, Qian, additional, Zheng, Ai-Hong, additional, Zhou, Hong-Ying, additional, Chen, Yun, additional, Chen, Xiao-Chen, additional, Xiao, Jian-Yong, additional, Ying, Xu-Hua, additional, Wang, Fu-Wei, additional, Rui, Tao, additional, Liao, Yi-Ji, additional, Xie, Dan, additional, Lu, Li-Qin, additional, and Huang, Dong-Sheng, additional

Published
2016
Full Text
View/download PDF

141. Evidence for transcriptional interference in a dual-luciferase reporter system

Author

Wu, Guo-Qing, primary, Wang, Xiao, additional, Zhou, Hong-Ying, additional, Chai, Ke-Qun, additional, Xue, Qian, additional, Zheng, Ai-Hong, additional, Zhu, Xiu-Ming, additional, Xiao, Jian-Yong, additional, Ying, Xu-Hua, additional, Wang, Fu-Wei, additional, Rui, Tao, additional, Xu, Li-Yun, additional, Zhang, Yong-Kui, additional, Liao, Yi-Ji, additional, Xie, Dan, additional, Lu, Li-Qin, additional, and Huang, Dong-Sheng, additional

Published
2015
Full Text
View/download PDF

144. Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation

Author

Huang, Dong-Sheng, primary, Wang, Zhaohui, additional, He, Xu-Jun, additional, Diplas, Bill H., additional, Yang, Rui, additional, Killela, Patrick J., additional, Meng, Qun, additional, Ye, Zai-Yuan, additional, Wang, Wei, additional, Jiang, Xiao-Ting, additional, Xu, Li, additional, He, Xiang-Lei, additional, Zhao, Zhong-Sheng, additional, Xu, Wen-Juan, additional, Wang, Hui-Ju, additional, Ma, Ying-Yu, additional, Xia, Ying-Jie, additional, Li, Li, additional, Zhang, Ru-Xuan, additional, Jin, Tao, additional, Zhao, Zhong-Kuo, additional, Xu, Ji, additional, Yu, Sheng, additional, Wu, Fang, additional, Liang, Junbo, additional, Wang, Sizhen, additional, Jiao, Yuchen, additional, Yan, Hai, additional, and Tao, Hou-Quan, additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results