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106 results on '"Huang, David Y."'

101. Unique role of proximal rectal dose in late rectal complications for patients with cervical cancer undergoing high-dose-rate intracavitary brachytherapy

Author

Cheng, Jason Chia-Hsien, Peng, Lee-Cheng, Chen, Yu-Hsuan, Huang, David Y. C., Wu, Jian-Kuen, and Jian, James Jer-Min

Subjects
*RECTAL cancer, *RADIOTHERAPY, *CANCER complications, *RADIOISOTOPE brachytherapy, *RADIATION doses, *RADIATION injuries, *RECTUM, *RECTAL diseases, *RETROSPECTIVE studies, *DISEASE complications, CERVIX uteri tumors
Abstract

: PurposeTo investigate the correlation of the radiation dose to the upper rectum, proximal to the International Commission of Radiation Units and Measurements (ICRU) rectal point, with late rectal complications in patients treated with external beam radiotherapy (EBRT) and high-dose-rate (HDR) intracavitary brachytherapy (ICRT) for carcinoma of the uterine cervix.: Methods and materialsBetween June 1997 and February 2001, 75 patients with cervical carcinoma completed definitive or preoperative RT and were retrospectively reviewed. Of the 75 patients, 62 with complete dosimetric data and a minimal follow-up of at least 1 year were included in this analysis. Of the 62 patients, 36 (58%) also received concurrent chemotherapy, mainly with cisplatin during EBRT. EBRT consisted of a mean of 50.1 ± 1.3 Gy of 18-MV photons to the pelvis. A parametrial boost was given to 55 patients. Central shielding was used after 40–45 Gy of pelvic RT. HDR ICRT followed EBRT, with a median dose of 5 Gy/fraction given twice weekly for a median of four fractions. The mean dose to point A from HDR ICRT was 23.9 ± 3.0 Gy. In addition to the placement of a rectal tube with a lead wire during ICRT, 30–40 mL of contrast medium was instilled into the rectum to demonstrate the anterior rectal wall up to the rectosigmoid junction. Late rectal complications were recorded according to the Radiation Therapy Oncology Group grading system. The maximal rectal dose taken along the rectum from the anal verge to the rectosigmoid junction and the ICRU rectal dose were calculated. Statistical tests were used for the correlation of Grade 2 or greater rectal complications with patient-related variables and dosimetric factors. Correlations among the point A dose, ICRU rectal dose, and maximal proximal rectal dose were analyzed.: ResultsFourteen patients (23%) developed Grade 2 or greater rectal complications. Patient-related factors, definitive or preoperative RT, and the use of concurrent chemotherapy were not associated with the occurrence of rectal complications. The maximal rectal dose during ICRT was at the proximal rectum rather than at the ICRU rectal point in 55 (89%) of 62 patients. Patients with Grade 2 or greater rectal complications had received a significantly greater total maximal proximal rectal dose from ICRT (25.6 Gy vs. 19.2 Gy, p = 0.019) and had a greater maximal proximal rectal dose/point A dose ratio (1.025 vs. 0.813, p = 0.024). In contrast, patients with and without rectal complications had a similar dose at point A (25.0 Gy vs.23.6 Gy, p = 0.107). The differences in the ICRU rectal dose (17.8 Gy vs.15.4 Gy, p = 0.065) and the ICRU rectal dose/point A dose ratio (0.71 vs. 0.66, p = 0.210) did not reach statistical significance. Patients with >62 Gy of a direct dose sum from EBRT and ICRT to the proximal rectum (12 of 29 vs. 2 of 33, p = 0.001) and >110 Gy of a total maximal proximal rectal biologic effective dose (13 of 40 vs. 1 of 22, p = 0.012) presented with a significantly increased frequency of Grade 2 or greater rectal complications. The correlations between the maximal proximal rectal dose and the ICRU rectal dose were less satisfactory (Pearson coefficient 0.375). Moreover, 11 of the 14 patients with rectal complications had colonoscopic findings of radiation colitis at the proximal rectum, the area with the maximal rectal dose.: ConclusionEighty-nine percent of our patients had a maximal rectal dose from ICRT at the proximal rectum instead of the ICRU rectal point. The difference between patients with and without late rectal complications was more prominent for the proximal rectal dose than for the ICRU rectal dose. It is important and useful to contrast the whole rectal wall up to the rectosigmoid junction and to calculate the dose at the proximal rectum for patients undergoing HDR ICRT. [Copyright &y& Elsevier]

Published
2003
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102. Colaboradores

Author

Runge, Marschall S., Greganti, M. Andrew, Adimora, Adaora A., Alattar, Maha, Aris, Robert M., Bae-Jump, Victoria Lin, Baggstrom, Maria Q., Barritt, A. Sidney, Bassim, Marc K., Bates, Toby, Beaven, Anne W., Berger, Robert G., Berkowitz, Lee R., Bernard, Stephen A., Blau, William S., Boggess, John F., Bowman, Mary C., Brecher, Mark E., Bromberg, Philip A., Brown, Sue A., Brown, Vickie, Bryson, Paul C., Buckmire, Robert A., Bullitt, Elizabeth, Burkhart, Craig, Busby-Whitehead, M. Janette, Buse, John B., Bynum, Debra L., Carey, Lisa A., Carey, Timothy S., Carson, Culley C., III, Chang, Patricia P., Chaudhary, Sanjay, Clemmons, David R., Coghill, James M., Colindres, Romulo E., Connolly, AnnaMarie, Copeland, Benjamin J., Correll, Todd, Denu-Ciocca, Cynthia J., Devetski, Thomas S., DeWalt, Darren A., Diaz, Luis A., Donohue, James F., Dooley, Mary Anne, Dostou, Jean M., Drossman, Douglas A., Dupree, Carla Sueta, Eapen, Rose J., Ebert, Charles S., Jr., Erdem, Nurum F., Eron, Joseph J., Falk, Ronald J., Farmer-Boatwright, Mary Katherine, Fasy, Elizabeth A., Finkel, Alan G., Finn, William F., Fitzgerald, David P., Ford, Carol A., Forneris, Catherine A., Fowler, Amy M., Fowler, W. Craig, Fowler, Wesley Caswell, Fried, Michael W., Gabriel, Don A., Galvin, Shannon, Gangarosa, Lisa M., Garbutt, James C., Gay, Cynthia, Gaylord, Susan A., Gettes, Leonard S., Ghio, Andrew J., Gilmore, John H., Godley, Paul A., Goldberg, Lee R., Goldberg, Richard M., Goldenberg, Matthew N., Goldstein, Brian P., Greenwood, Robert S., Grimm, Ian S., Grossman, Steven H., Gwyther, Robert E., Haggerty, John J., Jr., Harris, Russell P., Heizer, William D., Henderson, Ashley G., Henke, David C., Hill, Michael A., Hinderliter, Alan L., Hinn, Albert R., Hladik, Gerald A., Hoffman, Hal M., Hosseinipour, Mina C., Howard, James F., Jr., Huang, David Y., Huang, Xuemei, Hutto, Burton R., Isaacs, Kim L., Israel, Bruce F., Ivester, Thomas S., Jacobe, Heidi T., Jacobson, Peter Lars, Jantac, Lukas, Jawanda, Jaspaul S., Johnson, Sandra M., Jonas, Beth L., Jordan, Joanne M., Juliano, Jonathan J., Kahn, Kevin A., Kaplan, Andrew H., Key, Nigel S., Kim, William Y., Kizer, John S., Klein, Caroline M., Klemmer, Philip J., Kölln, Karen, Koruda, Mark J., Kurz, James E., LaCour, Jeffrey, Ladha, Alim M., Leight, W. Derek, Leone, Peter A., Lindsey, B. Anthony, Madanick, Ryan D., Mandelkehr, Lawrence K., Mann, J. Douglas, Markovic-Plese, Silva, Marshall, Allen F., Mattern, William D., Mayer, Celeste M., Meredith, Travis A., Miller, William C., Mitchell, Beverly S., Moll, Stephan, Morgan, Douglas R., Morrell, Dean S., Muñoz, M. Cristina, Nachman, Patrick H., Nelson, Kelly C., Nester, Carla M., Nicholas, Linda M., Ohman, E. Magnus, O'Neil, Bert H., Ontjes, David A., Orlowski, Robert Z., Parsons, Daniel J., Patel, Dhavalkumar D., Patterson, Cam, Patterson, Kristine B., Peppercorn, Amanda, Pillsbury III, Harold C., Rathmell, W. Kimryn, Reuland, Daniel S., Ringel, Yehuda, Rivera, M. Patricia, Rosebrock, Craig N., Rosenberg, Pinchas, Roubey, Robert A.S., Rubenstein, David S., Runge, Susan Riggs, Russo, Mark, Rutala, William A., Sanders, William E., Jr., Sanoff, Hanna K., Sanoff, Scott L., Scarlett, Yolanda V., Schwarz, Emily J., Senior, Brent A., Serody, Jonathan S., Shaheen, Nicholas J., Shea, Thomas C., Sheahan, Richard G., Shockley, William W., Shrestha, Roshan, Sickbert-Bennett, Emily E., Sickel, Micah J., Sikich, Linmarie, Simpson, Ross J., Jr., Smith, Sidney C., Jr., Socinski, Mark A., Sparling, P. Frederick, Stinchcombe, Thomas E., Stouffer, George A., Tarrant, Teresa K., Taylor, Mark, Thomas, Michael J., Thomas, Nancy E., Thorpe, John M., Jr., Tilley, Stephen L., Ting, Jenny P., Tomsick, Robert S., van der Horst, Charles M., Vaughn, Bradley V., Vick, Pamela G., Vissers, Robert J., Voorhees, Peter M., Wang, Tracy Y., Watson, Lea C., Weber, David J., Wehbie, Robert S., Weissler, Mark C., Wells, Ellen C., Whang, Young E., Willis, Park W., IV, Winfield, John B., Winzelberg, Gary S., Wohl, David A., Wong, Leslie P., Wu, Diem N., and Zacks, Steven

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103. Contributors

Author

Runge, Marschall S., Greganti, M. Andrew, Adimora, Adaora A., Alattar, Maha, Aris, Robert M., Bae-Jump, Victoria Lin, Baggstrom, Maria Q., Barritt, A. Sidney, Bassim, Marc K., Bates, Toby, Beaven, Anne W., Berger, Robert G., Berkowitz, Lee R., Bernard, Stephen A., Blau, William S., Boggess, John F., Bowman, Mary C., Brecher, Mark E., Bromberg, Philip A., Brown, Sue A., Brown, Vickie, Bryson, Paul C., Buckmire, Robert A., Bullitt, Elizabeth, Burkhart, Craig, Busby-Whitehead, M. Janette, Buse, John B., Bynum, Debra L., Carey, Lisa A., Carey, Timothy S., Carson, Culley C., III, Chang, Patricia P., Chaudhary, Sanjay, Clemmons, David R., Coghill, James M., Colindres, Romulo E., Connolly, AnnaMarie, Copeland, Benjamin J., Correll, Todd, Denu-Ciocca, Cynthia J., Devetski, Thomas S., DeWalt, Darren A., Diaz, Luis A., Donohue, James F., Dooley, Mary Anne, Dostou, Jean M., Drossman, Douglas A., Dupree, Carla Sueta, Eapen, Rose J., Ebert, Charles S., Jr., Erdem, Nurum F., Eron, Joseph J., Falk, Ronald J., Farmer-Boatwright, Mary Katherine, Fasy, Elizabeth A., Finkel, Alan G., Finn, William F., Fitzgerald, David P., Ford, Carol A., Forneris, Catherine A., Fowler, Amy M., Fowler, W. Craig, Fowler, Wesley Caswell, Fried, Michael W., Gabriel, Don A., Galvin, Shannon, Gangarosa, Lisa M., Garbutt, James C., Gay, Cynthia, Gaylord, Susan A., Gettes, Leonard S., Ghio, Andrew J., Gilmore, John H., Godley, Paul A., Goldberg, Lee R., Goldberg, Richard M., Goldenberg, Matthew N., Goldstein, Brian P., Greenwood, Robert S., Grimm, Ian S., Grossman, Steven H., Gwyther, Robert E., Haggerty, John J., Jr., Harris, Russell P., Heizer, William D., Henderson, Ashley G., Henke, David C., Hill, Michael A., Hinderliter, Alan L., Hinn, Albert R., Hladik, Gerald A., Hoffman, Hal M., Hosseinipour, Mina C., Howard, James F., Jr., Huang, David Y., Huang, Xuemei, Hutto, Burton R., Isaacs, Kim L., Israel, Bruce F., Ivester, Thomas S., Jacobe, Heidi T., Jacobson, Peter Lars, Jantac, Lukas, Jawanda, Jaspaul S., Johnson, Sandra M., Jonas, Beth L., Jordan, Joanne M., Juliano, Jonathan J., Kahn, Kevin A., Kaplan, Andrew H., Key, Nigel S., Kim, William Y., Kizer, John S., Klein, Caroline M., Klemmer, Philip J., Kölln, Karen, Koruda, Mark J., Kurz, James E., LaCour, Jeffrey, Ladha, Alim M., Leight, W. Derek, Leone, Peter A., Lindsey, B. Anthony, Madanick, Ryan D., Mandelkehr, Lawrence K., Mann, J. Douglas, Markovic-Plese, Silva, Marshall, Allen F., Mattern, William D., Mayer, Celeste M., Meredith, Travis A., Miller, William C., Mitchell, Beverly S., Moll, Stephan, Morgan, Douglas R., Morrell, Dean S., Muñoz, M. Cristina, Nachman, Patrick H., Nelson, Kelly C., Nester, Carla M., Nicholas, Linda M., Ohman, E. Magnus, O'Neil, Bert H., Ontjes, David A., Orlowski, Robert Z., Parsons, Daniel J., Patel, Dhavalkumar D., Patterson, Cam, Patterson, Kristine B., Peppercorn, Amanda, Pillsbury, Harold C., III, Rathmell, W. Kimryn, Reuland, Daniel S., Ringel, Yehuda, Rivera, M. Patricia, Rosebrock, Craig N., Rosenberg, Pinchas, Roubey, Robert A.S., Rubenstein, David S., Runge, Susan Riggs, Russo, Mark, Rutala, William A., Sanders, William E., Jr., Sanoff, Hanna K., Sanoff, Scott L., Scarlett, Yolanda V., Schwarz, Emily J., Senior, Brent A., Serody, Jonathan S., Shaheen, Nicholas J., Shea, Thomas C., Sheahan, Richard G., Shockley, William W., Shrestha, Roshan, Sickbert-Bennett, Emily E., Sickel, Micah J., Sikich, Linmarie, Simpson, Ross J., Jr., Smith, Sidney C., Jr., Socinski, Mark A., Sparling, P. Frederick, Stinchcombe, Thomas E., Stouffer, George A., Tarrant, Teresa K., Taylor, Mark, Thomas, Michael J., Thomas, Nancy E., Thorpe, John M., Jr., Tilley, Stephen L., Ting, Jenny P., Tomsick, Robert S., van der Horst, Charles M., Vaughn, Bradley V., Vick, Pamela G., Vissers, Robert J., Voorhees, Peter M., Wang, Tracy Y., Watson, Lea C., Weber, David J., Wehbie, Robert S., Weissler, Mark C., Wells, Ellen C., Whang, Young E., Willis, Park W., IV, Winfield, John B., Winzelberg, Gary S., Wohl, David A., Wong, Leslie P., Wu, Diem N., and Zacks, Steven

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105. Concurrent life-course trajectories of employment and marijuana-use: exploring interdependence of longitudinal outcomes.

Author

Hara M, Huang DY, Weiss RE, and Hser YI

Subjects
Adult, Age Factors, Female, Humans, Longitudinal Studies, Male, National Longitudinal Study of Adolescent Health, Sex Factors, Time Factors, Young Adult, Efficiency, Employment statistics & numerical data, Marijuana Smoking epidemiology
Abstract

This study analyzes data on 7661 individuals who participated in the 1979 National Longitudinal Survey of Youth (NLSY79) to estimate trajectories of employment and marijuana-use over a 17-year period. Bivariate random intercept and slope modeling is applied to examine concurrently the cross-correlation between the two concurrent longitudinal trajectories from age 23 to 39. Parameter estimates indicate baseline level (at age 23) of employment to be negatively correlated with marijuana, suggesting marijuana-use is associated with lower workforce productivity at age 23. The longitudinal employment slope is positively correlated with employment intercept for both males and females, indicating that survey participants with higher levels of employment at age 23 are more likely to have a positive impact on employment trajectory over time. For males, however, the employment slope is also significantly correlated with marijuana intercept (r=-0.07), indicating marijuana-use in early adulthood may uniquely lower workforce productivity over age., (Published by Elsevier Inc.)

Published
2013
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106. Association between adolescent substance use and obesity in young adulthood: a group-based dual trajectory analysis.

Author

Huang DY, Lanza HI, and Anglin MD

Subjects
Adolescent, Child, Female, Humans, Longitudinal Studies, Male, Risk Factors, Young Adult, Alcohol Drinking adverse effects, Marijuana Smoking adverse effects, Obesity psychology, Smoking adverse effects
Abstract

Purpose: This study investigated whether and how trajectories of substance use in adolescence were associated with obesity trajectories in young adulthood. We hypothesized that: (1) exposure to persistent substance use throughout adolescence may heighten obesity risk in young adulthood; and (2) such associations may differ once gender, ethnicity, socioeconomic status, and obesity status in adolescence, are considered., Methods: The study included 5141 adolescents from the child sample of the 1979 National Longitudinal Survey of Youth and utilized biennial data across the 12 assessments (1986-2008) to examine trajectories of substance use behaviors (i.e., cigarette smoking, alcohol use, and marijuana use) from ages 12 to 18 and obesity trajectories from ages 20 to 24. Group-based dual trajectory modeling was applied to examine sequential associations of trajectories of each type of substance use behavior with obesity trajectories., Results: Three distinctive trajectory patterns were respectively identified for cigarette smoking, alcohol use, and marijuana use from ages 12 to 18, as well as for obesity status (BMI ≥ 30) from ages 20 to 24. Taking into account gender, ethnicity, socioeconomic status, and obesity status in adolescence, adolescents with the most problematic smoking trajectory (High-decreasing) were more likely to exhibit a High-obesity trajectory from ages 20 to 24. Also, adolescents with an Increasing marijuana use trajectory were more likely to exhibit an Increased obesity trajectory in young adulthood., Conclusions: The current study demonstrates that adolescent substance use is associated with subsequent obesity in young adulthood. The associations appear to differ based on the type of substance use and patterns of use., (© 2013 Elsevier Ltd. All rights reserved.)

Published
2013
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