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355 results on '"Hu, Zhimin"'

104. Enhanced visible-light-driven hydrogen evolution of ultrathin narrow-band-gap g-C3N4 nanosheets.

Author

Yu, Tao, Hu, Zhimin, Wang, Hongmei, and Tan, Xin

Subjects
*NITRIDES, *HYDROGEN as fuel, *LIGHT absorbance, *VISIBLE spectra, *HYDROGEN, *SOLAR energy
Abstract

To broaden the light response range of semiconductor photocatalysts and improve the efficiency of photocatalytic reaction are the focuses of the production of clean hydrogen energy through solar photocatalytic water splitting. Metal-free graphitic carbon nitride (g-C3N4) is an efficient visible-light-driven photocatalytic material. In this study, a kind of narrow-band-gap g-C3N4 has been synthesized at high synthesis temperature under hydrogen argon mixture. And then a two-step method of ultrasonication and calcination treatment was used to synthesize ultrathin g-C3N4 nanosheets with much bigger specific surface area. The results of characterization analysis indicate that the as-prepared ultrathin narrow-band-gap g-C3N4 nanosheets show great light absorbance in visible light and high photogenerated charge separation capability. And the as-prepared ultrathin g-C3N4 nanosheets exhibit significantly enhanced photocatalytic performance for photocatalytic hydrogen evolution under visible light (λ > 480 nm). [ABSTRACT FROM AUTHOR]

Published
2020
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105. Enzymatic O‐Prenylation of Diverse Phenolic Compounds by a Permissive O‐Prenyltransferase from the Medicinal Mushroom Antrodia camphorata.

Author

He, Junbin, Hu, Zhimin, Dong, Zeyuan, Li, Bin, Chen, Kuan, Shang, Zhanpeng, Zhang, Meng, Qiao, Xue, and Ye, Min

Subjects
*PHENOLS, *BIODIVERSITY, *NATURAL products, *DRUG derivatives, *MUSHROOMS
Abstract

Prenylated compounds are pharmacologically attractive natural products that are widely distributed in nature. Prenyltransferases (PTs) could catalyze the transfer of prenyl moieties to aromatic acceptors and increase the structural diversity and biological activity of natural products. In this work, a permissive O‐prenyltransferase AcaPT was discovered from Antrodia camphorata, a precious medicinal mushroom in Taiwan. AcaPT exhibited robust O‐prenylation capability toward structurally diverse drug‐like phenolic compounds, including antrodins, flavonoids, and coumarins. In total, 23 O‐prenylated products were obtained by scaled‐up enzymatic synthesis. AcaPT could be used as an efficient biocatalyst to synthesize O‐prenylated derivatives for drug discovery. [ABSTRACT FROM AUTHOR]

Published
2020
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108. Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet‐induced insulin‐resistant mice

Author

Zhang, Feifei, primary, Hu, Zhimin, additional, Li, Gaopeng, additional, Huo, Shaofeng, additional, Ma, Fengguang, additional, Cui, Aoyuan, additional, Xue, Yaqian, additional, Han, Yamei, additional, Gong, Qi, additional, Gao, Jing, additional, Bian, Hua, additional, Meng, Zhuoxian, additional, Wu, Haifu, additional, Long, Gang, additional, Tan, Yi, additional, Zhang, Yan, additional, Lin, Xu, additional, Gao, Xin, additional, Xu, Aimin, additional, and Li, Yu, additional

Published
2018
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111. Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21

Author

Sun, Yixuan, primary, Xia, Mingfeng, additional, Yan, Hongmei, additional, Han, Yamei, additional, Zhang, Feifei, additional, Hu, Zhimin, additional, Cui, Aoyuan, additional, Ma, Fengguang, additional, Liu, Zhengshuai, additional, Gong, Qi, additional, Chen, Xuqing, additional, Gao, Jing, additional, Bian, Hua, additional, Tan, Yi, additional, Li, Yu, additional, and Gao, Xin, additional

Published
2017
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112. Electron Temperature Measurement of Radiation-Heated CH Foam on Shenguang II Laser Facility

Author

Yang Jia-Min, Zhu Tuo, Xiong Gang, Yang Guo-Hong, Zhang Ji-Yan, Hu Zhimin, Zhao Yang, Wei Minxi, Jin Feng-Tao, and Shang Wanli

Subjects
Absorption spectroscopy, Opacity, Analytical chemistry, chemistry.chemical_element, Radiation, Condensed Matter Physics, Laser, law.invention, chemistry, Aluminium, law, TRACER, Electron temperature, Atomic physics, FOIL method
Abstract

A spectroscopic diagnostic method, to measure electron temperature of radiation-heated CH foam on Shenguang II laser facility, is described. A tracer layer of aluminum was embedded in the middle of the CH foam and a point-projection method used in the opacity experiment was induced to measure the transmission spectrum of the embedded A1 foil. The electron temperature, of about 80 eV, was deduced through a comparison of the experimental absorption spectrum with the calculated one with a detailed level accounting opacity code. The results of hydrodynamic simulation show that it's reasonable to determine the CH foam temperature by measuring the embedded Al absorption spectrum. Thus, the electron temperature of radiation-heated CH foam was obtained.

Published
2010

113. Novel Method of the Wavelength Determination of Spectral Lines with Planar Crystal Spectrometer

Author

刘劲松 Liu Jinsong, 甘新式 Gan Xinshi, 杨家敏 Yang Jiamin, 袁孝 Yuan Xiao, 张继彦 Zhang Jiyan, 胡智民 Hu Zhimin, 韦敏习 Wei Minxi, and 赵阳 Zhao Yang

Subjects
Wavelength, Materials science, Optics, Planar, Spectrometer, business.industry, Crystal spectrometer, Electrical and Electronic Engineering, business, Atomic and Molecular Physics, and Optics, Spectral line, Electronic, Optical and Magnetic Materials
Published
2008

117. K-shell photoabsorption edge of strongly coupled aluminum driven by laser-converted radiation

Author

Zhao, Yang, primary, Zhang, Zhiyu, additional, Qing, Bo, additional, Yang, Jiamin, additional, Zhang, Jiyan, additional, Wei, Minxi, additional, Yang, Guohong, additional, Song, Tianming, additional, Xiong, Gang, additional, Lv, Min, additional, Hu, Zhimin, additional, Deng, Bo, additional, Hu, Xin, additional, Zhang, Wenhai, additional, Shang, Wanli, additional, Hou, Lifei, additional, Du, Huabing, additional, Zhan, Xiayu, additional, and Yu, Ruizhen, additional

Published
2017
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120. Fluorescence imaging as a diagnostic of M-band x-ray drive condition in hohlraum with fluorescent Si targets

Author

Li, Qi, primary, Hu, Zhimin, additional, Yao, Li, additional, Huang, Chengwu, additional, Yuan, Zheng, additional, Zhao, Yang, additional, Xiong, Gang, additional, Qing, Bo, additional, Lv, Min, additional, Zhu, Tuo, additional, Deng, Bo, additional, Li, Jin, additional, Wei, Minxi, additional, Zhan, Xiayu, additional, Li, Jun, additional, Yang, Yimeng, additional, Su, Chunxiao, additional, Yang, Guohong, additional, Zhang, Jiyan, additional, Li, Sanwei, additional, Yang, Jiamin, additional, and Ding, Yongkun, additional

Published
2016
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121. Fluorescence based imaging for M-band drive symmetry measurement in hohlraum

Author

Li, Qi, primary, Yao, Li, additional, Jing, Longfei, additional, Hu, Zhimin, additional, Huang, Chengwu, additional, Yuan, Zheng, additional, Zhao, Yang, additional, Xiong, Gang, additional, Qing, Bo, additional, Lv, Min, additional, Zhu, Tuo, additional, Deng, Bo, additional, Li, Jin, additional, Wei, Minxi, additional, Zhan, Xiayu, additional, Li, Jun, additional, Yang, Yimeng, additional, Su, Chunxiao, additional, Yang, Guohong, additional, Zhang, Jiyan, additional, Li, Sanwei, additional, Yang, Jiamin, additional, and Ding, Yongkun, additional

Published
2016
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122. Targeting pancreatic cancer cells by a novel hydroxamate-based histone deacetylase (HDAC) inhibitor ST-3595

Author

Hu Zhimin, Shang Minjie, Wu Weiding, Hong Defei, and Zhang Yuhua

Subjects
Apoptosis, Biology, Hydroxamic Acids, Mitochondrial Membrane Transport Proteins, Histone Deacetylases, Mice, Pancreatic cancer, Cyclosporin a, Cell Line, Tumor, medicine, Cytotoxic T cell, Animals, Humans, Mitochondrial Permeability Transition Pore, Cancer, General Medicine, medicine.disease, Molecular biology, Xenograft Model Antitumor Assays, Gemcitabine, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Histone Deacetylase Inhibitors, Pancreatic Neoplasms, Cancer cell, Cancer research, Histone deacetylase, medicine.drug
Abstract

In the current study, we tested the potential anti-pancreatic cancer activity of a novel hydroxamate-based histone deacetylase (HDAC) inhibitor ST-3595. We showed that ST-3595 exerted potent anti-proliferative and cytotoxic activities against both established pancreatic cancer cell lines (PANC-1, AsPC-1, and Mia-PaCa-2), and patient-derived primary cancer cells. It was, however, generally safe to non-cancerous pancreatic epithelial HPDE6c7 cells. ST-3595-induced cytotoxicity to pancreatic cancer cells was associated with significant apoptosis activation. Reversely, the pan caspase inhibitor z-VAD-fmk and the caspase-8 inhibitor z-ITED-fmk alleviated ST-3595-mediated anti-pancreatic cancer activity in vitro. For the mechanism study, ST-3595 inhibited HDAC activity, and induced mitochondrial permeability transition pore (MPTP) opening in pancreatic cancer cells. Inhibition of MPTP, by cyclosporin A, sanglifehrin A, or by cyclophilin-D (Cyp-D) siRNA knockdown, dramatically inhibited ST-3595-induced pancreatic cancer cell apoptosis. Meanwhile, we found that a low concentration of ST-3595 dramatically sensitized gemcitabine-induced anti-pancreatic cancer cell activity in vitro. In vivo, ST-3595 oral administration inhibited PANC-1 xenograft growth in nude mice, and this activity was further enhanced when in combination with gemcitabine. In summary, the results of this study suggest that targeting HDACs by ST-3595 might represent as a novel and promising anti-pancreatic cancer strategy.

Published
2015

123. Cigarette Smoke Extract Promotes TIM4 Expression in Murine Dendritic Cells Leading to Th2 Polarization through ERK-Dependent Pathways.

Author

Jiang, Rui, Jiang, Yaping, Xia, Ping, Luo, Guangwei, Huang, Wei, Hu, Zhimin, Cheng, Guilian, Xiong, Yin, Wang, Yueqin, and Cui, Tianpen

Subjects
CIGARETTE smoke, DENDRITIC cells, TH2 cells, INDOOR air pollution, BONE marrow, MITOGEN-activated protein kinases, PROTEIN kinases
Abstract

Smoking is considered to be the main source of indoor pollution, and it has been identified as an important environmental factor contributing to asthma onset. We know that T helper 2 (Th2) response plays a crucial role in the process of asthma disease. We have investigated the reaction of cigarette smoke extract (CSE) on Th polarization which is controlled by dendritic cells (DCs). Stimulated by CSE, immature DCs from murine bone marrow showed upregulated levels of TIM4. Cocultured with CD4+ T cells, stimulated DCs increased the ratio of IL-4+ versus IFN-γ+ of CD4+ T cells. This suggests a differentiation towards Th2 response. Moreover, antibodies against TIM4 reversed the upexpression of the IL-4+/IFN-γ+ ratio provoked by CSE, indicating that the Th2 polarization which was induced by CSE is via TIM4 mechanisms. CSE could activate mitogen-activated protein kinase pathways like ERK and p38. Upregulation of TIM4 expression by CSE stimulation was found to be inhibited by an ERK inhibitor but not p38 and JNK. In conclusion, DC-induced Th2 polarization is a hallmark of CSE allergy, and this aspect can be explained by CSE-induced TIM4 expression. [ABSTRACT FROM AUTHOR]

Published
2019
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124. An experimental study on damage of retina function due to toxicity of carbon disulfide and lipid peroxidation

Author

Dong Yingli, Tian Qingfen, Hu Zhimin, Guo Xirang, Yin Weijing, and Li Jianduan

Subjects
chemistry.chemical_classification, medicine.medical_specialty, Retina, genetic structures, biology, medicine.diagnostic_test, business.industry, Glutathione peroxidase, Retinal, Superoxide dismutase, Lipid peroxidation, Ophthalmology, chemistry.chemical_compound, medicine.anatomical_structure, Endocrinology, chemistry, Biochemistry, Internal medicine, Toxicity, biology.protein, medicine, sense organs, business, Erg, Electroretinography
Abstract

PURPOSE To study the relation between the changes in the electroretinogram and the lipid peroxidation of the retina during the period of retinal damage due to carbon disulfide (CS2). METHODS To examine the amplitude and latency of a, b waves of the electroretinogram (ERG) and to assay the activities of total superoxide dismutases (TSOD), (EC no. 1.15.1.1), glutathione peroxidase (GSH-Px) (EC no.1.11.1.9) and malondialdehyed (MDA) in the retina of animals with experimental CS2 toxic retinopathy. RESULTS The b wave amplitude (161+/-51 microv) of the animals exposed to CS2 for 3 weeks was significantly lower than that of the controls (310+/-93 microv) (p

Published
1999

125. Erratum: Polarization measurement of dielectronic recombination transitions in highly charged krypton ions [Phys. Rev. A92, 042702 (2015)]

Author

Shah, Chintan, primary, Jörg, Holger, additional, Bernitt, Sven, additional, Dobrodey, Stepan, additional, Steinbrügge, René, additional, Beilmann, Christian, additional, Amaro, Pedro, additional, Hu, Zhimin, additional, Weber, Sebastian, additional, Fritzsche, Stephan, additional, Surzhykov, Andrey, additional, Crespo López-Urrutia, José R., additional, and Tashenov, Stanislav, additional

Published
2016
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126. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

Author

Gong, Qi, primary, Hu, Zhimin, additional, Zhang, Feifei, additional, Cui, Aoyuan, additional, Chen, Xin, additional, Jiang, Haoyang, additional, Gao, Jing, additional, Chen, Xuqing, additional, Han, Yamei, additional, Liang, Qingning, additional, Ye, Dewei, additional, Shi, Lei, additional, Chin, Y. Eugene, additional, Wang, Yu, additional, Xiao, Hui, additional, Guo, Feifan, additional, Liu, Yong, additional, Zang, Mengwei, additional, Xu, Aimin, additional, and Li, Yu, additional

Published
2016
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127. Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator–Activated Receptor α

Author

Chen, Xuqing, primary, Zhang, Feifei, additional, Gong, Qi, additional, Cui, Aoyuan, additional, Zhuo, Shu, additional, Hu, Zhimin, additional, Han, Yamei, additional, Gao, Jing, additional, Sun, Yixuan, additional, Liu, Zhengshuai, additional, Yang, Zhongnan, additional, Le, Yingying, additional, Gao, Xianfu, additional, Dong, Lily Q., additional, Gao, Xin, additional, and Li, Yu, additional

Published
2016
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128. OPACITY MEASUREMENT AND THEORETICAL INVESTIGATION OF HOT SILICON PLASMA

Author

Xiong, Gang, primary, Yang, Jiamin, additional, Zhang, Jiyan, additional, Hu, Zhimin, additional, Zhao, Yang, additional, Qing, Bo, additional, Yang, Guohong, additional, Wei, Minxi, additional, Yi, Rongqing, additional, Song, Tianming, additional, Li, Hang, additional, Yuan, Zheng, additional, Lv, Min, additional, Meng, Xujun, additional, Xu, Yan, additional, Wu, Zeqing, additional, and Yan, Jun, additional

Published
2015
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129. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometric identification and antifungal susceptibility analysis of Candidaspecies isolated from patients with invasive yeast infections in five university hospitals

Author

Hu, Zhimin, Zhang, Juling, Chen, Zhongju, Jin, Zhengjiang, Leng, Pei, Zhou, Junying, and Xie, Xiaofang

Abstract

In this multicenter study, we compared the performance of the Bruker Biotyper MS system and VITEK 2 YST systems for invasive yeast identification, investigated the distribution of isolated species, and evaluated the antifungal susceptibility profiles of Candida albicans, Candida parapsilosis, and Candida tropicalis. In cases of discrepant results lack of identification with either method, molecular identification techniques were employed. We tested 216 clinical isolates, and concordance between the two methods was observed for 192/216 isolates (88.9%). For five unidentified strains (2.3%), an internal transcribed spacer (ITS) sequencing approach was used. In brief, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF MS) provided short turnaround times and more reliable results than those of Vitek 2 YST. In Wuhan, C. albicans, C. parapsilosis, Candida glabrata, and C. tropicaliswere the most common pathogens (93.0%) in patients with candidemia. Cryptococcus neoformanswas mainly detected in cerebrospinal fluid samples (88.9%). Trichosporon asahiiwere all isolated from drainage fluids in the Surgery. Candida albicanswas clearly susceptible to azoles, while C. parapsilosisand C. tropicalisdisplayed differences in susceptibility to azoles. Our findings provide a basis for the practical application of MALDI-ToF MS for identification and for the use of ATB FUNGUS 3 to characterize the susceptibility of Candidaspp., thereby providing significant data for therapeutic decisions.

Published
2019
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130. Polarization measurement of dielectronic recombination transitions in highly charged krypton ions

Author

Shah, Chintan, primary, Jörg, Holger, additional, Bernitt, Sven, additional, Dobrodey, Stepan, additional, Steinbrügge, René, additional, Beilmann, Christian, additional, Amaro, Pedro, additional, Hu, Zhimin, additional, Weber, Sebastian, additional, Fritzsche, Stephan, additional, Surzhykov, Andrey, additional, Crespo López-Urrutia, José R., additional, and Tashenov, Stanislav, additional

Published
2015
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131. Linear polarization of x rays due to dielectronic recombination into highly charged ions

Author

Shah, Chintan, primary, Jörg, Holger, additional, Hu, Zhimin, additional, Bernitt, Sven, additional, Bekker, Hendrik, additional, Blessenohl, Michael A., additional, Hollain, Daniel, additional, Weber, Sebastian, additional, Dobrodey, Stepan, additional, Fritzsche, Stephan, additional, Surzhykov, Andrey, additional, López-Urrutia, José R Crespó, additional, and Tashenov, Stanislav, additional

Published
2015
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132. Realization of a flat-response photocathode for x-ray streak cameras

Author

Wang, Chuanke, primary, Li, Jin, additional, Hu, Xin, additional, Hu, Zhimin, additional, Zhu, Xiaoli, additional, Deng, Bo, additional, Yi, Tao, additional, Fan, Quanping, additional, Cao, Zhurong, additional, Liu, Shenye, additional, Jiang, Shaoen, additional, Ding, Yongkun, additional, Xie, Changqing, additional, and Jiang, Gang, additional

Published
2015
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140. A new testing technique for researching procedure in curing of high polymers

Author

Chen Daqian, Fan Jiang, Hu Zhimin, and Ge Zhengyan

Subjects
chemistry.chemical_classification, Materials science, chemistry, Differential thermal analysis, Polymer chemistry, System testing, Polymer, Dielectric, Dissipation, Composite material, Thermal analysis, Curing (chemistry), Dielectric thermal analysis
Abstract

The authors describe multifunction test equipment for measuring and recording the dielectric spectrum, thermogram, and start-end gel-time of a high polymer specimen from liquid state to cure state. It is shown that the change of the polymer from liquid to solid during a complex cure process can be sensitively and accurately monitored by the dielectric analysis technique. A correlation of three parameters (viscosity, differential thermal analysis, and dielectric dissipation analysis) is established in order to supervise the technological measurement. >

Published
2002

150. Time-Resolved Measurement of Radiatively Heated Iron 2 p −3 d Transmission Spectra

Author

Hu Zhimin, Yang Guo-Hong, Shang Wanli, Wei Minxi, Xiong Gang, Yang Jia-Min, Jin Feng-Tao, Zhao Yang, and Zhang Ji-Yan

Subjects
Materials science, Absorption spectroscopy, business.industry, Detector, General Physics and Astronomy, Plasma, Grating, Laser, Spectral line, law.invention, Optics, Transmission (telecommunications), law, Microchannel plate detector, business
Abstract

An experimental measurement of radiatively heated iron plasma transmission spectra was performed on Shenguang II laser facility. In the measurement, the self-emission spectrum, the backlighting spectrum, and the absorption spectrum were imaged with a flat filed grating and recorded on a gated micro channel plate detector to obtain the time-resolved transmission spectra in the range 10–20 A (approximately 0.6–1.3keV). Experimental results are compared with the calculation results of an unsolved transition array (UTA) code. The time-dependent relative shift in the positions of the 2p−3d transmission array is interpreted in terms of the plasma temperature variations.

Published
2010

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