20,845 results on '"Howard, D"'
Search Results
102. 10-Alkoxy-anthracenyl-isoxazole analogs have sub-micromolar activity against a Glioblastoma multiforme cell line
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Duncan, Nathan S., Campbell, Michael J., Backos, Donald S., Li, Chun, Rider, Kevin C., Stump, Sascha, Weaver, Matthew J., Gajewski, Mariusz P., Beall, Howard D., Reigan, Philip, and Natale, Nicholas R.
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- 2022
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103. Effects of vitamin C supplementation on gout risk: results from the Physicians’ Health Study II trial
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Juraschek, Stephen P, Gaziano, J Michael, Glynn, Robert J, Gomelskaya, Natalya, Bubes, Vadim Y, Buring, Julie E, Shmerling, Robert H, and Sesso, Howard D
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- 2022
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104. Helicobacter pylori Seropositivity, ABO Blood Type, and Pancreatic Cancer Risk from 5 Prospective Cohorts
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Lee, Alice A., Wang, Qiao-Li, Kim, Jihye, Babic, Ana, Zhang, Xuehong, Perez, Kimberly, Ng, Kimmie, Nowak, Jonathan, Rifazzzzzzzzgi, Nader, Sesso, Howard D., Buring, Julie E., Anderson, Garnet L., Wactawski-Wende, Jean, Wallace, Robert, Manson, JoAnn E., Giovannucci, Edward L., Stampfer, Meir J., Kraft, Peter, Fuchs, Charles S., Yuan, Chen, and Wolpin, Brian M.
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- 2023
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105. Conditional Distribution-Based Downweighting for Robust Estimation of Logistic Regression Models
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Yu, Weichang, primary and Bondell, Howard D., additional
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- 2022
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106. Sermons
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Weinbrot, Howard D., primary
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- 2022
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107. Prediction of the Resonance Frequency of the Pipe Carrying Fluid Relative to the Fluid Velocity
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Ahmad, H. Y., primary, Jweeg, M. J., additional, and Howard, D. C., additional
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- 2022
- Full Text
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108. Biological effects of inhaled crude oil vapor V. Altered biogenic amine neurotransmitters and neural protein expression
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Sriram, Krishnan, Lin, Gary X., Jefferson, Amy M., McKinney, Walter, Jackson, Mark C., Cumpston, Jared L., Cumpston, James B., Leonard, Howard D., Kashon, Michael L., and Fedan, Jeffrey S.
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- 2022
- Full Text
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109. Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study
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Kouli, O, Murray, V, Bhatia, S, Cambridge, WA, Kawka, M, Shafi, S, Knight, SR, Kamarajah, SK, McLean, KA, Glasbey, JC, Khaw, RA, Ahmed, W, Akhbari, M, Baker, D, Borakati, A, Mills, E, Thavayogan, R, Yasin, I, Raubenheimer, K, Ridley, W, Sarrami, M, Zhang, G, Egoroff, N, Pockney, P, Richards, T, Bhangu, A, Creagh-Brown, B, Edwards, M, Harrison, EM, Lee, M, Nepogodiev, D, Pinkney, T, Pearse, R, Smart, N, Vohra, R, Sohrabi, C, Jamieson, A, Nguyen, M, Rahman, A, English, C, Tincknell, L, Kakodkar, P, Kwek, I, Punjabi, N, Burns, J, Varghese, S, Erotocritou, M, McGuckin, S, Vayalapra, S, Dominguez, E, Moneim, J, Salehi, M, Tan, HL, Yoong, A, Zhu, L, Seale, B, Nowinka, Z, Patel, N, Chrisp, B, Harris, J, Maleyko, I, Muneeb, F, Gough, M, James, CE, Skan, O, Chowdhury, A, Rebuffa, N, Khan, H, Down, B, Fatimah Hussain, Q, Adams, M, Bailey, A, Cullen, G, Fu, YXJ, McClement, B, Taylor, A, Aitken, S, Bachelet, B, Brousse de Gersigny, J, Chang, C, Khehra, B, Lahoud, N, Lee Solano, M, Louca, M, Rozenbroek, P, Rozitis, E, Agbinya, N, Anderson, E, Arwi, G, Barry, I, Batchelor, C, Chong, T, Choo, LY, Clark, L, Daniels, M, Goh, J, Handa, A, Hanna, J, Huynh, L, Jeon, A, Kanbour, A, Lee, A, Lee, J, Lee, T, Leigh, J, Ly, D, McGregor, F, Moss, J, Nejatian, M, O'Loughlin, E, Ramos, I, Sanchez, B, Shrivathsa, A, Sincari, A, Sobhi, S, Swart, R, Trimboli, J, Wignall, P, Bourke, E, Chong, A, Clayton, S, Dawson, A, Hardy, E, Iqbal, R, Le, L, Mao, S, Marinelli, I, Metcalfe, H, Panicker, D, R, HH, Ridgway, S, Tan, HH, Thong, S, Van, M, Woon, S, Woon-Shoo-Tong, XS, Yu, S, Ali, K, Chee, J, Chiu, C, Chow, YW, Duller, A, Nagappan, P, Ng, S, Selvanathan, M, Sheridan, C, Temple, M, Do, JE, Dudi-Venkata, NN, Humphries, E, Li, L, Mansour, LT, Massy-Westropp, C, Fang, B, Farbood, K, Hong, H, Huang, Y, Joan, M, Koh, C, Liu, YHA, Mahajan, T, Muller, E, Park, R, Tanudisastro, M, Wu, JJG, Chopra, P, Giang, S, Radcliffe, S, Thach, P, Wallace, D, Wilkes, A, Chinta, SH, Li, J, Phan, J, Rahman, F, Segaran, A, Shannon, J, Zhang, M, Adams, N, Bonte, A, Choudhry, A, Colterjohn, N, Croyle, JA, Donohue, J, Feighery, A, Keane, A, McNamara, D, Munir, K, Roche, D, Sabnani, R, Seligman, D, Sharma, S, Stickney, Z, Suchy, H, Tan, R, Yordi, S, Ahmed, I, Aranha, M, El Sabawy, D, Garwood, P, Harnett, M, Holohan, R, Howard, R, Kayyal, Y, Krakoski, N, Lupo, M, McGilberry, W, Nepon, H, Scoleri, Y, Urbina, C, Ahmad Fuad, MF, Ahmed, O, Jaswantlal, D, Kelly, E, Khan, MHT, Naidu, D, Neo, WX, O'Neill, R, Sugrue, M, Abbas, JD, Abdul-Fattah, S, Azlan, A, Barry, K, Idris, NS, Kaka, N, Mc Dermott, D, Mohammad Nasir, MN, Mozo, M, Rehal, A, Shaikh Yousef, M, Wong, RH, Curran, E, Gardner, M, Hogan, A, Julka, R, Lasser, G, Ní Chorráin, N, Ting, J, Browne, R, George, S, Janjua, Z, Leung Shing, V, Megally, M, Murphy, S, Ravenscroft, L, Vedadi, A, Vyas, V, Bryan, A, Sheikh, A, Ubhi, J, Vannelli, K, Vawda, A, Adeusi, L, Doherty, C, Fitzgerald, C, Gallagher, H, Gill, P, Hamza, H, Hogan, M, Kelly, S, Larry, J, Lynch, P, Mazeni, NA, O'Connell, R, O'Loghlin, R, Singh, K, Abbas Syed, R, Ali, A, Alkandari, B, Arnold, A, Arora, E, Azam, R, Breathnach, C, Cheema, J, Compton, M, Curran, S, Elliott, JA, Jayasamraj, O, Mohammed, N, Noone, A, Pal, A, Pandey, S, Quinn, P, Sheridan, R, Siew, L, Tan, EP, Tio, SW, Toh, VTR, Walsh, M, Yap, C, Yassa, J, Young, T, Agarwal, N, Almoosawy, SA, Bowen, K, Bruce, D, Connachan, R, Cook, A, Daniell, A, Elliott, M, Fung, HKF, Irving, A, Laurie, S, Lee, YJ, Lim, ZX, Maddineni, S, McClenaghan, RE, Muthuganesan, V, Ravichandran, P, Roberts, N, Shaji, S, Solt, S, Toshney, E, Arnold, C, Baker, O, Belais, F, Bojanic, C, Byrne, M, Chau, CYC, De Soysa, S, Eldridge, M, Fairey, M, Fearnhead, N, Guéroult, A, Ho, JSY, Joshi, K, Kadiyala, N, Khalid, S, Khan, F, Kumar, K, Lewis, E, Magee, J, Manetta-Jones, D, Mann, S, McKeown, L, Mitrofan, C, Mohamed, T, Monnickendam, A, Ng, AYKC, Ortu, A, Patel, M, Pope, T, Pressling, S, Purohit, K, Saji, S, Shah Foridi, J, Shah, R, Siddiqui, SS, Surman, K, Utukuri, M, Varghese, A, Williams, CYK, Yang, JJ, Billson, E, Cheah, E, Holmes, P, Hussain, S, Murdock, D, Nicholls, A, Patel, P, Ramana, G, Saleki, M, Spence, H, Thomas, D, Yu, C, Abousamra, M, Brown, C, Conti, I, Donnelly, A, Durand, M, French, N, Goan, R, O'Kane, E, Rubinchik, P, Gardiner, H, Kempf, B, Lai, YL, Matthews, H, Minford, E, Rafferty, C, Reid, C, Sheridan, N, Al Bahri, T, Bhoombla, N, Rao, BM, Titu, L, Chatha, S, Field, C, Gandhi, T, Gulati, R, Jha, R, Jones Sam, MT, Karim, S, Patel, R, Saunders, M, Sharma, K, Abid, S, Heath, E, Kurup, D, Patel, A, Ali, M, Cresswell, B, Felstead, D, Jennings, K, Kaluarachchi, T, Lazzereschi, L, Mayson, H, Miah, JE, Reinders, B, Rosser, A, Thomas, C, Williams, H, Al-Hamid, Z, Alsadoun, L, Chlubek, M, Fernando, P, Gaunt, E, Gercek, Y, Maniar, R, Ma, R, Matson, M, Moore, S, Morris, A, Nagappan, PG, Ratnayake, M, Rockall, L, Shallcross, O, Sinha, A, Tan, KE, Virdee, S, Wenlock, R, Donnelly, HA, Ghazal, R, Hughes, I, Liu, X, McFadden, M, Misbert, E, Mogey, P, O'Hara, A, Peace, C, Rainey, C, Raja, P, Salem, M, Salmon, J, Tan, CH, Alves, D, Bahl, S, Baker, C, Coulthurst, J, Koysombat, K, Linn, T, Rai, P, Sharma, A, Shergill, A, Ahmed, M, Ahmed, S, Belk, LH, Choudhry, H, Cummings, D, Dixon, Y, Dobinson, C, Edwards, J, Flint, J, Franco Da Silva, C, Gallie, R, Gardener, M, Glover, T, Greasley, M, Hatab, A, Howells, R, Hussey, T, Khan, A, Mann, A, Morrison, H, Ng, A, Osmond, R, Padmakumar, N, Pervaiz, F, Prince, R, Qureshi, A, Sawhney, R, Sigurdson, B, Stephenson, L, Vora, K, Zacken, A, Cope, P, Di Traglia, R, Ferarrio, I, Hackett, N, Healicon, R, Horseman, L, Lam, LI, Meerdink, M, Menham, D, Murphy, R, Nimmo, I, Ramaesh, A, Rees, J, Soame, R, Dilaver, N, Adebambo, D, Brown, E, Burt, J, Foster, K, Kaliyappan, L, Knight, P, Politis, A, Richardson, E, Townsend, J, Abdi, M, Ball, M, Easby, S, Gill, N, Ho, E, Iqbal, H, Matthews, M, Nubi, S, Nwokocha, JO, Okafor, I, Perry, G, Sinartio, B, Vanukuru, N, Walkley, D, Welch, T, Yates, J, Yeshitila, N, Bryans, K, Campbell, B, Gray, C, Keys, R, Macartney, M, Chamberlain, G, Khatri, A, Kucheria, A, Lee, STP, Reese, G, Roy choudhury, J, Tan, WYR, Teh, JJ, Ting, A, Kazi, S, Kontovounisios, C, Vutipongsatorn, K, Amarnath, T, Balasubramanian, N, Bassett, E, Gurung, P, Lim, J, Panjikkaran, A, Sanalla, A, Alkoot, M, Bacigalupo, V, Eardley, N, Horton, M, Hurry, A, Isti, C, Maskell, P, Nursiah, K, Punn, G, Salih, H, Epanomeritakis, E, Foulkes, A, Henderson, R, Johnston, E, McCullough, H, McLarnon, M, Morrison, E, Cheung, A, Cho, SH, Eriksson, F, Hedges, J, Low, Z, May, C, Musto, L, Nagi, S, Nur, S, Salau, E, Shabbir, S, Thomas, MC, Uthayanan, L, Vig, S, Zaheer, M, Zeng, G, Ashcroft-Quinn, S, Brown, R, Hayes, J, McConville, R, French, R, Gilliam, A, Sheetal, S, Shehzad, MU, Bani, W, Christie, I, Franklyn, J, Khan, M, Russell, J, Smolarek, S, Varadarassou, R, Ahmed, SK, Narayanaswamy, S, Sealy, J, Shah, M, Dodhia, V, Manukyan, A, O'Hare, R, Orbell, J, Chung, I, Forenc, K, Gupta, A, Agarwal, A, Al Dabbagh, A, Bennewith, R, Bottomley, J, Chu, TSM, Chu, YYA, Doherty, W, Evans, B, Hainsworth, P, Hosfield, T, Li, CH, McCullagh, I, Mehta, A, Thaker, A, Thompson, B, Virdi, A, Walker, H, Wilkins, E, Dixon, C, Hassan, MR, Lotca, N, Tong, KS, Batchelor-Parry, H, Chaudhari, S, Harris, T, Hooper, J, Johnson, C, Mulvihill, C, Nayler, J, Olutobi, O, Piramanayagam, B, Stones, K, Sussman, M, Weaver, C, Alam, F, Al Rawi, M, Andrew, F, Arrayeh, A, Azizan, N, Hassan, A, Iqbal, Z, John, I, Jones, M, Kalake, O, Keast, M, Nicholas, J, Patil, A, Powell, K, Roberts, P, Sabri, A, Segue, AK, Shah, A, Shaik Mohamed, SA, Shehadeh, A, Shenoy, S, Tong, A, Upcott, M, Vijayasingam, D, Anarfi, S, Dauncey, J, Devindaran, A, Havalda, P, Komninos, G, Mwendwa, E, Norman, C, Richards, J, Urquhart, A, Allan, J, Cahya, E, Hunt, H, McWhirter, C, Norton, R, Roxburgh, C, Tan, JY, Ali Butt, S, Hansdot, S, Haq, I, Mootien, A, Sanchez, I, Vainas, T, Deliyannis, E, Tan, M, Vipond, M, Chittoor Satish, NN, Dattani, A, De Carvalho, L, Gaston-Grubb, M, Karunanithy, L, Lowe, B, Pace, C, Raju, K, Roope, J, Taylor, C, Youssef, H, Munro, T, Thorn, C, Wong, KHF, Yunus, A, Chawla, S, Datta, A, Dinesh, AA, Field, D, Georgi, T, Gwozdz, A, Hamstead, E, Howard, N, Isleyen, N, Jackson, N, Kingdon, J, Sagoo, KS, Schizas, A, Yin, L, Aung, E, Aung, YY, Franklin, S, Han, SM, Kim, WC, Martin Segura, A, Rossi, M, Ross, T, Tirimanna, R, Wang, B, Zakieh, O, Ben-Arzi, H, Flach, A, Jackson, E, Magers, S, Olu abara, C, Rogers, E, Sugden, K, Tan, H, Veliah, S, Walton, U, Asif, A, Bharwada, Y, Bowley, D, Broekhuizen, A, Cooper, L, Evans, N, Girdlestone, H, Ling, C, Mann, H, Mehmood, N, Mulvenna, CL, Rainer, N, Trout, I, Gujjuri, R, Jeyaraman, D, Leong, E, Singh, D, Smith, E, Anderton, J, Barabas, M, Goyal, S, Howard, D, Joshi, A, Mitchell, D, Weatherby, T, Badminton, R, Bird, R, Burtle, D, Choi, NY, Devalia, K, Farr, E, Fischer, F, Fish, J, Gunn, F, Jacobs, D, Johnston, P, Kalakoutas, A, Lau, E, Loo, YNAF, Louden, H, Makariou, N, Mohammadi, K, Nayab, Y, Ruhomaun, S, Ryliskyte, R, Saeed, M, Shinde, P, Sudul, M, Theodoropoulou, K, Valadao-Spoorenberg, J, Vlachou, F, Arshad, SR, Janmohamed, AM, Noor, M, Oyerinde, O, Saha, A, Syed, Y, Watkinson, W, Ahmadi, H, Akintunde, A, Alsaady, A, Bradley, J, Brothwood, D, Burton, M, Higgs, M, Hoyle, C, Katsura, C, Lathan, R, Louani, A, Mandalia, R, Prihartadi, AS, Qaddoura, B, Sandland-Taylor, L, Thadani, S, Thompson, A, Walshaw, J, Teo, S, Ali, S, Bawa, JH, Fox, S, Gargan, K, Haider, SA, Hanna, N, Hatoum, A, Khan, Z, Krzak, AM, Li, T, Pitt, J, Tan, GJS, Ullah, Z, Wilson, E, Cleaver, J, Colman, J, Copeland, L, Coulson, A, Davis, P, Faisal, H, Hassan, F, Hughes, JT, Jabr, Y, Mahmoud Ali, F, Nahaboo Solim, ZN, Sangheli, A, Shaya, S, Thompson, R, Cornwall, H, De Andres Crespo, M, Fay, E, Findlay, J, Groves, E, Jones, O, Killen, A, Millo, J, Thomas, S, Ward, J, Wilkins, M, Zaki, F, Zilber, E, Bhavra, K, Bilolikar, A, Charalambous, M, Elawad, A, Eleni, A, Fawdon, R, Gibbins, A, Livingstone, D, Mala, D, Oke, SE, Padmakumar, D, Patsalides, MA, Payne, D, Ralphs, C, Roney, A, Sardar, N, Stefanova, K, Surti, F, Timms, R, Tosney, G, Bannister, J, Clement, NS, Cullimore, V, Kamal, F, Lendor, J, McKay, J, Mcswiggan, J, Minhas, N, Seneviratne, K, Simeen, S, Valverde, J, Watson, N, Bloom, I, Dinh, TH, Hirniak, J, Joseph, R, Kansagra, M, Lai, CKN, Melamed, N, Patel, J, Randev, J, Sedighi, T, Shurovi, B, Sodhi, J, Vadgama, N, Abdulla, S, Adabavazeh, B, Champion, A, Chennupati, R, Chu, K, Devi, S, Haji, A, Schulz, J, Testa, F, Davies, P, Gurung, B, Howell, S, Modi, P, Pervaiz, A, Zahid, M, Abdolrazaghi, S, Abi Aoun, R, Anjum, Z, Bawa, G, Bhardwaj, R, Brown, S, Enver, M, Gill, D, Gopikrishna, D, Gurung, D, Kanwal, A, Kaushal, P, Khanna, A, Lovell, E, McEvoy, C, Mirza, M, Nabeel, S, Naseem, S, Pandya, K, Perkins, R, Pulakal, R, Ray, M, Reay, C, Reilly, S, Round, A, Seehra, J, Shakeel, NM, Singh, B, Vijay Sukhnani, M, Brown, L, Desai, B, Elzanati, H, Godhaniya, J, Kavanagh, E, Kent, J, Kishor, A, Liu, A, Norwood, M, Shaari, N, Wood, C, Wood, M, Brown, A, Chellapuri, A, Ferriman, A, Ghosh, I, Kulkarni, N, Noton, T, Pinto, A, Rajesh, S, Varghese, B, Wenban, C, Aly, R, Barciela, C, Brookes, T, Corrin, E, Goldsworthy, M, Mohamed Azhar, MS, Moore, J, Nakhuda, S, Ng, D, Pillay, S, Port, S, Abdullah, M, Akinyemi, J, Islam, S, Kale, A, Lewis, A, Manjunath, T, McCabe, H, Misra, S, Stubley, T, Tam, JP, Waraich, N, Chaora, T, Ford, C, Osinkolu, I, Pong, G, Rai, J, Risquet, R, Ainsworth, J, Ayandokun, P, Barham, E, Barrett, G, Barry, J, Bisson, E, Bridges, I, Burke, D, Cann, J, Cloney, M, Coates, S, Cripps, P, Davies, C, Francis, N, Green, S, Handley, G, Hathaway, D, Hurt, L, Jenkins, S, Johnston, C, Khadka, A, McGee, U, Morris, D, Murray, R, Norbury, C, Pierrepont, Z, Richards, C, Ross, O, Ruddy, A, Salmon, C, Shield, M, Soanes, K, Spencer, N, Taverner, S, Williams, C, Wills-Wood, W, Woodward, S, Chow, J, Fan, J, Guest, O, Hunter, I, Moon, WY, Arthur-Quarm, S, Edwards, P, Hamlyn, V, McEneaney, L, N D, G, Pranoy, S, Ting, M, Abada, S, Alawattegama, LH, Ashok, A, Carey, C, Gogna, A, Haglund, C, Hurley, P, Leelo, N, Liu, B, Mannan, F, Paramjothy, K, Ramlogan, K, Raymond-Hayling, O, Shanmugarajah, A, Solichan, D, Wilkinson, B, Ahmad, NA, Allan, D, Amin, A, Bakina, C, Burns, F, Cameron, F, Campbell, A, Cavanagh, S, Chan, SMZ, Chapman, S, Chong, V, Edelsten, E, Ekpete, O, El Sheikh, M, Ghose, R, Hassane, A, Henderson, C, Hilton-Christie, S, Husain, M, Hussain, H, Javid, Z, Johnson-Ogbuneke, J, Johnston, A, Khalil, M, Leung, TCC, Makin, I, Muralidharan, V, Naeem, M, Patil, P, Ravichandran, S, Saraeva, D, Shankey-Smith, W, Sharma, N, Swan, R, Waudby-West, R, Wilkinson, A, Wright, K, Balasubramanian, A, Bhatti, S, Chalkley, M, Chou, WK, Dixon, M, Evans, L, Fisher, K, Gandhi, P, Ho, S, Lau, YB, Lowe, S, Meechan, C, Murali, N, Musonda, C, Njoku, P, Ochieng, L, Pervez, MU, Seebah, K, Shaikh, I, Sikder, MA, Vanker, R, Alom, J, Bajaj, V, Coleman, O, Finch, G, Goss, J, Jenkins, C, Kontothanassis, A, Liew, MS, Ng, K, Outram, M, Shakeel, MM, Tawn, J, Zuhairy, S, Chapple, K, Cinnamond, A, Coleman, S, George, HA, Goulder, L, Hare, N, Hawksley, J, Kret, A, Luesley, A, Mecia, L, Porter, H, Puddy, E, Richardson, G, Sohail, B, Srikaran, V, Tadross, D, Tobin, J, Tokidis, E, Young, L, Ashdown, T, Bratsos, S, Koomson, A, Kufuor, A, Lim, MQ, Shah, S, Thorne, EPC, Warusavitarne, J, Xu, S, Abigail, S, Ahmed, A, Ahmed, J, Akmal, A, Al-Khafaji, M, Amini, B, Arshad, M, Bogie, E, Brazkiewicz, M, Carroll, M, Chandegra, A, Cirelli, C, Deng, A, Fairclough, S, Fung, YJ, Gornell, C, Green, RL, Green, SV, Gulamhussein, AHM, Isaac, AG, Jan, R, Jegatheeswaran, L, Knee, M, Kotecha, J, Kotecha, S, Maxwell-Armstrong, C, McIntyre, C, Mendis, N, Naing, TKP, Oberman, J, Ong, ZX, Ramalingam, A, Saeed Adam, A, Tan, LL, Towell, S, Yadav, J, Anandampillai, R, Chung, S, Hounat, A, Ibrahim, B, Jeyakumar, G, Khalil, A, Khan, UA, Nair, G, Owusu-Ayim, M, Wilson, M, Kanani, A, Kilkelly, B, Ogunmwonyi, I, Ong, L, Samra, B, Schomerus, L, Shea, J, Turner, O, Yang, Y, Amin, M, Blott, N, Clark, A, Feather, A, Forrest, M, Hague, S, Hamilton, K, Higginbotham, G, Hope, E, Karimian, S, Loveday, K, Malik, H, McKenna, O, Noor, A, Onsiong, C, Patel, B, Radcliffe, N, Shah, P, Tye, L, Verma, K, Walford, R, Yusufi, U, Zachariah, M, Casey, A, Doré, C, Fludder, V, Fortescue, L, Kalapu, SS, Karel, E, Khera, G, Smith, C, Appleton, B, Ashaye, A, Boggon, E, Evans, A, Faris Mahmood, H, Hinchcliffe, Z, Marei, O, Silva, I, Spooner, C, Thomas, G, Timlin, M, Wellington, J, Yao, SL, Abdelrazek, M, Abdelrazik, Y, Bee, F, Joseph, A, Mounce, A, Parry, G, Vignarajah, N, Biddles, D, Creissen, A, Kolhe, S, K, T, Lea, A, Ledda, V, O'Loughlin, P, Scanlon, J, Shetty, N, Weller, C, Abdalla, M, Adeoye, A, Bhatti, M, Chadda, KR, Chu, J, Elhakim, H, Foster-Davies, H, Rabie, M, Tailor, B, Webb, S, Abdelrahim, ASA, Choo, SY, Jiwa, A, Mangam, S, Murray, S, Shandramohan, A, Aghanenu, O, Budd, W, Hayre, J, Khanom, S, Liew, ZY, McKinney, R, Moody, N, Muhammad-Kamal, H, Odogwu, J, Patel, D, Roy, C, Sattar, Z, Shahrokhi, N, Sinha, I, Thomson, E, Wonga, L, Bain, J, Khan, J, Ricardo, D, Bevis, R, Cherry, C, Darkwa, S, Drew, W, Griffiths, E, Konda, N, Madani, D, Mak, JKC, Meda, B, Odunukwe, U, Preest, G, Raheel, F, Rajaseharan, A, Ramgopal, A, Risbrooke, C, Selvaratnam, K, Sethunath, G, Tabassum, R, Taylor, J, Thakker, A, Wijesingha, N, Wybrew, R, Yasin, T, Ahmed Osman, A, Alfadhel, S, Carberry, E, Chen, JY, Drake, I, Glen, P, Jayasuriya, N, Kawar, L, Myatt, R, Sinan, LOH, Siu, SSY, Tjen, V, Adeboyejo, O, Bacon, H, Barnes, R, Birnie, C, D'Cunha Kamath, A, Hughes, E, Middleton, S, Owen, R, Schofield, E, Short, C, Smith, R, Wang, H, Willett, M, Zimmerman, M, Balfour, J, Chadwick, T, Coombe-Jones, M, Do Le, HP, Faulkner, G, Hobson, K, Shehata, Z, Beattie, M, Chmielewski, G, Chong, C, Donnelly, B, Drusch, B, Ellis, J, Farrelly, C, Feyi-Waboso, J, Hibell, I, Hoade, L, Ho, C, Jones, H, Kodiatt, B, Lidder, P, Ni Cheallaigh, L, Norman, R, Patabendi, I, Penfold, H, Playfair, M, Pomeroy, S, Ralph, C, Rottenburg, H, Sebastian, J, Sheehan, M, Stanley, V, Welchman, J, Ajdarpasic, D, Antypas, A, Azouaghe, O, Basi, S, Bettoli, G, Bhattarai, S, Bommireddy, L, Bourne, K, Budding, J, Cookey-Bresi, R, Cummins, T, Davies, G, Fabelurin, C, Gwilliam, R, Hanley, J, Hird, A, Kruczynska, A, Langhorne, B, Lund, J, Lutchman, I, McGuinness, R, Neary, M, Pampapathi, S, Pang, E, Podbicanin, S, Rai, N, Redhouse White, G, Sujith, J, Thomas, P, Walker, I, Winterton, R, Anderson, P, Barrington, M, Bhadra, K, Clark, G, Fowler, G, Gibson, C, Hudson, S, Kaminskaite, V, Lawday, S, Longshaw, A, MacKrill, E, McLachlan, F, Murdeshwar, A, Nieuwoudt, R, Parker, P, Randall, R, Rawlins, E, Reeves, SA, Rye, D, Sirkis, T, Sykes, B, Ventress, N, Wosinska, N, Akram, B, Burton, L, Coombs, A, Long, R, Magowan, D, Ong, C, Sethi, M, Williams, G, Chan, C, Chan, LH, Fernando, D, Gaba, F, Khor, Z, Les, JW, Mak, R, Moin, S, Ng Kee Kwong, KC, Paterson-Brown, S, Tew, YY, Bardon, A, Burrell, K, Coldwell, C, Costa, I, Dexter, E, Hardy, A, Khojani, M, Mazurek, J, Raymond, T, Reddy, V, Reynolds, J, Soma, A, Agiotakis, S, Alsusa, H, Desai, N, Peristerakis, I, Adcock, A, Ayub, H, Bennett, T, Bibi, F, Brenac, S, Chapman, T, Clarke, G, Clark, F, Galvin, C, Gwyn-Jones, A, Henry-Blake, C, Kerner, S, Kiandee, M, Lovett, A, Pilecka, A, Ravindran, R, Siddique, H, Sikand, T, Treadwell, K, Akmal, K, Apata, A, Barton, O, Broad, G, Darling, H, Dhuga, Y, Emms, L, Habib, S, Jain, R, Jeater, J, Kan, CYP, Kathiravelupillai, A, Khatkar, H, Kirmani, S, Kulasabanathan, K, Lacey, H, Lal, K, Manafa, C, Mansoor, M, McDonald, S, Mittal, A, Mustoe, S, Nottrodt, L, Oliver, P, Papapetrou, I, Pattinson, F, Raja, M, Reyhani, H, Shahmiri, A, Small, O, Soni, U, Aguirrezabala Armbruster, B, Bunni, J, Hakim, MA, Hawkins-Hooker, L, Howell, KA, Hullait, R, Jaskowska, A, Ottewell, L, Thomas-Jones, I, Vasudev, A, Clements, B, Fenton, J, Gill, M, Haider, S, Lim, AJM, Maguire, H, McMullan, J, Nicoletti, J, Samuel, S, Unais, MA, White, N, Yao, PC, Yow, L, Boyle, C, Brady, R, Cheekoty, P, Cheong, J, Chew, SJHL, Chow, R, Ganewatta Kankanamge, D, Mamer, L, Mohammed, B, Ng Chieng Hin, J, Renji Chungath, R, Royston, A, Sharrad, E, Sinclair, R, Tingle, S, Treherne, K, Wyatt, F, Maniarasu, VS, Moug, S, Appanna, T, Bucknall, T, Hussain, F, Owen, A, Parry, M, Parry, R, Sagua, N, Spofforth, K, Yuen, ECT, Bosley, N, Hardie, W, Moore, T, Regas, C, Abdel-Khaleq, S, Ali, N, Bashiti, H, Buxton-Hopley, R, Constantinides, M, D'Afflitto, M, Deshpande, A, Duque Golding, J, Frisira, E, Germani Batacchi, M, Gomaa, A, Hay, D, Hutchison, R, Iakovou, A, Iakovou, D, Ismail, E, Jefferson, S, Jones, L, Khouli, Y, Knowles, C, Mason, J, McCaughan, R, Moffatt, J, Morawala, A, Nadir, H, Neyroud, F, Nikookam, Y, Parmar, A, Pinto, L, Ramamoorthy, R, Richards, E, Thomson, S, Trainer, C, Valetopoulou, A, Vassiliou, A, Wantman, A, Wilde, S, Dickinson, M, Rockall, T, Senn, D, Wcislo, K, Zalmay, P, Adelekan, K, Allen, K, Bajaj, M, Gatumbu, P, Hang, S, Hashmi, Y, Kaur, T, Kawesha, A, Kisiel, A, Woodmass, M, Adelowo, T, Ahari, D, Alhwaishel, K, Atherton, R, Clayton, B, Cockroft, A, Curtis Lopez, C, Hilton, M, Ismail, N, Kouadria, M, Lee, L, MacConnachie, A, Monks, F, Mungroo, S, Nikoletopoulou, C, Pearce, L, Sara, X, Shahid, A, Suresh, G, Wilcha, R, Atiyah, A, Davies, E, Dermanis, A, Gibbons, H, Hyde, A, Lawson, A, Lee, C, Leung-Tack, M, Li Saw Hee, J, Mostafa, O, Nair, D, Pattani, N, Plumbley-Jones, J, Pufal, K, Ramesh, P, Sanghera, J, Saram, S, Scadding, S, See, S, Stringer, H, Torrance, A, Vardon, H, Wyn-Griffiths, F, Brew, A, Kaur, G, Soni, D, Tickle, A, Akbar, Z, Appleyard, T, Figg, K, Jayawardena, P, Johnson, A, Kamran Siddiqui, Z, Lacy-Colson, J, Oatham, R, Rowlands, B, Sludden, E, Turnbull, C, Allin, D, Ansar, Z, Azeez, Z, Dale, VH, Garg, J, Horner, A, Jones, S, Knight, S, McGregor, C, McKenna, J, McLelland, T, Packham-Smith, A, Rowsell, K, Spector-Hill, I, Adeniken, E, Baker, J, Bartlett, M, Chikomba, L, Connell, B, Deekonda, P, Dhar, M, Elmansouri, A, Gamage, K, Goodhew, R, Hanna, P, Knight, J, Luca, A, Maasoumi, N, Mahamoud, F, Manji, S, Marwaha, PK, Mason, F, Oluboyede, A, Pigott, L, Razaq, AM, Richardson, M, Saddaoui, I, Wijeyendram, P, Yau, S, Atkins, W, Liang, K, Miles, N, Praveen, B, Ashai, S, Braganza, J, Common, J, Cundy, A, Davies, R, Guthrie, J, Handa, I, Iqbal, M, Ismail, R, Jones, C, Jones, I, Lee, KS, Levene, A, Okocha, M, Olivier, J, Smith, A, Subramaniam, E, Tandle, S, Wang, A, Watson, A, Wilson, C, Chan, XHF, Khoo, E, Montgomery, C, Norris, M, Pugalenthi, PP, Common, T, Cook, E, Mistry, H, Shinmar, HS, Agarwal, G, Bandyopadhyay, S, Brazier, B, Carroll, L, Goede, A, Harbourne, A, Lakhani, A, Lami, M, Larwood, J, Martin, J, Merchant, J, Pattenden, S, Pradhan, A, Raafat, N, Rothwell, E, Shammoon, Y, Sudarshan, R, Vickers, E, Wingfield, L, Ashworth, I, Azizi, S, Bhate, R, Chowdhury, T, Christou, A, Davies, L, Dwaraknath, M, Farah, Y, Garner, J, Gureviciute, E, Hart, E, Jain, A, Javid, S, Kankam, HK, Kaur Toor, P, Kaz, R, Kermali, M, Khan, I, Mattson, A, McManus, A, Murphy, M, Nair, K, Ngemoh, D, Norton, E, Olabiran, A, Parry, L, Payne, T, Pillai, K, Price, S, Punjabi, K, Raghunathan, A, Ramwell, A, Raza, M, Ritehnia, J, Simpson, G, Smith, W, Sodeinde, S, Studd, L, Subramaniam, M, Thomas, J, Towey, S, Tsang, E, Tuteja, D, Vasani, J, Vio, M, Badran, A, Adams, J, Anthony Wilkinson, J, Asvandi, S, Austin, T, Bald, A, Bix, E, Carrick, M, Chander, B, Chowdhury, S, Cooper Drake, B, Crosbie, S, D Portela, S, Francis, D, Gallagher, C, Gillespie, R, Gravett, H, Gupta, P, Ilyas, C, James, G, Johny, J, Jones, A, Kinder, F, MacLeod, C, Macrow, C, Maqsood-Shah, A, Mather, J, McCann, L, McMahon, R, Mitham, E, Mohamed, M, Munton, E, Nightingale, K, O'Neill, K, Onyemuchara, I, Senior, R, Shanahan, A, Sherlock, J, Spyridoulias, A, Stavrou, C, Stokes, D, Tamang, R, Taylor, E, Trafford, C, Uden, C, Waddington, C, Yassin, D, Zaman, M, Bangi, S, Cheng, T, Chew, D, Hussain, N, Imani-Masouleh, S, Mahasivam, G, McKnight, G, Ng, HL, Ota, HC, Pasha, T, Ravindran, W, Shah, K, Vishnu K, S, Zaman, S, Carr, W, Cope, S, Eagles, EJ, Howarth-Maddison, M, Li, CY, Reed, J, Ridge, A, Stubbs, T, Teasdaled, D, Umar, R, Worthington, J, Dhebri, A, Kalenderov, R, Alattas, A, Arain, Z, Bhudia, R, Chia, D, Daniel, S, Dar, T, Garland, H, Girish, M, Hampson, A, Kyriacou, H, Lehovsky, K, Mullins, W, Omorphos, N, Vasdev, N, Venkatesh, A, Waldock, W, Bhandari, A, Brown, G, Choa, G, Eichenauer, CE, Ezennia, K, Kidwai, Z, Lloyd-Thomas, A, Macaskill Stewart, A, Massardi, C, Sinclair, E, Skajaa, N, Smith, M, Tan, I, Afsheen, N, Anuar, A, Azam, Z, Bhatia, P, Davies-kelly, N, Dickinson, S, Elkawafi, M, Ganapathy, M, Gupta, S, Khoury, EG, Licudi, D, Mehta, V, Neequaye, S, Nita, G, Tay, VL, Zhao, S, Botsa, E, Cuthbert, H, Elliott, J, Furlepa, M, Lehmann, J, Mangtani, A, Narayan, A, Nazarian, S, Parmar, C, Shah, D, Shaw, C, Zhao, Z, Beck, C, Caldwell, S, Clements, JM, French, B, Kenny, R, Kirk, S, Lindsay, J, McClung, A, McLaughlin, N, Watson, S, Whiteside, E, Alyacoubi, S, Arumugam, V, Beg, R, Dawas, K, Garg, S, Lloyd, ER, Mahfouz, Y, Manobharath, N, Moonesinghe, R, Morka, N, Patel, K, Prashar, J, Yip, S, Adeeko, ES, Ajekigbe, F, Bhat, A, Evans, C, Farrugia, A, Gurung, C, Long, T, Malik, B, Manirajan, S, Newport, D, Rayer, J, Ridha, A, Ross, E, Saran, T, Sinker, A, Waruingi, D, Allen, R, Al Sadek, Y, Alves do Canto Brum, H, Asharaf, H, Ashman, M, Balakumar, V, Barrington, J, Baskaran, R, Berry, A, Bhachoo, H, Bilal, A, Boaden, L, Chia, WL, Covell, G, Crook, D, Dadnam, F, Davis, L, De Berker, H, Doyle, C, Fox, C, Gruffydd-Davies, M, Hafouda, Y, Hill, A, Hubbard, E, Hunter, A, Inpadhas, V, Jamshaid, M, Jandu, G, Jeyanthi, M, Jones, T, Kantor, C, Kwak, SY, Malik, N, Matt, R, McNulty, P, Miles, C, Mohomed, A, Myat, P, Niharika, J, Nixon, A, O'Reilly, D, Parmar, K, Pengelly, S, Price, L, Ramsden, M, Turnor, R, Wales, E, Waring, H, Wu, M, Yang, T, Ye, TTS, Zander, A, Zeicu, C, Bellam, S, Francombe, J, Kawamoto, N, Rahman, MR, Sathyanarayana, A, Tang, HT, Cheung, J, Hollingshead, J, Page, V, Sugarman, J, Wong, E, Chiong, J, Fung, E, Kan, SY, Kiang, J, Kok, J, Krahelski, O, Liew, MY, Lyell, B, Sharif, Z, Speake, D, Alim, L, Amakye, NY, Chandrasekaran, J, Chandratreya, N, Drake, J, Owoso, T, Thu, YM, Abou El Ela Bourquin, B, Alberts, J, Chapman, D, Rehnnuma, N, Ainsworth, K, Carpenter, H, Emmanuel, T, Fisher, T, Gabrel, M, Guan, Z, Hollows, S, Hotouras, A, Ip Fung Chun, N, Jaffer, S, Kallikas, G, Kennedy, N, Lewinsohn, B, Liu, FY, Mohammed, S, Rutherfurd, A, Situ, T, Stammer, A, Taylor, F, Thin, N, Urgesi, E, Zhang, N, Ahmad, MA, Bishop, A, Bowes, A, Dixit, A, Glasson, R, Hatta, S, Hatt, K, Larcombe, S, Preece, J, Riordan, E, Fegredo, D, Haq, MZ, Li, C, McCann, G, Stewart, D, Baraza, W, Bhullar, D, Burt, G, Coyle, J, Deans, J, Devine, A, Hird, R, Ikotun, O, Manchip, G, Ross, C, Storey, L, Tan, WWL, Tse, C, Warner, C, Whitehead, M, Wu, F, Court, EL, Crisp, E, Huttman, M, Mayes, F, Robertson, H, Rosen, H, Sandberg, C, Smith, H, Al Bakry, M, Ashwell, W, Bajaj, S, Bandyopadhyay, D, Browlee, O, Burway, S, Chand, CP, Elsayeh, K, Elsharkawi, A, Evans, E, Ferrin, S, Fort-Schaale, A, Iacob, M, I, K, Impelliziere Licastro, G, Mankoo, AS, Olaniyan, T, Otun, J, Pereira, R, Reddy, R, Saeed, D, Simmonds, O, Singhal, G, Tron, K, Wickstone, C, Williams, R, Bradshaw, E, De Kock Jewell, V, Houlden, C, Knight, C, Metezai, H, Mirza-Davies, A, Seymour, Z, Spink, D, and Wischhusen, S
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- 2022
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110. Sex Differences Across the Life Course: A Focus On Unique Nutritional and Health Considerations among Women
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Bailey, Regan L, Dog, Tieraona Low, Smith-Ryan, Abbie E, Das, Sai Krupa, Baker, Fiona C, Madak-Erdogan, Zeynep, Hammond, Billy R, Sesso, Howard D, Eapen, Alex, Mitmesser, Susan H, Wong, Andrea, and Nguyen, Haiuyen
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- 2022
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111. Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
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Sesso, Howard D, Manson, JoAnn E, Aragaki, Aaron K, Rist, Pamela M, Johnson, Lisa G, Friedenberg, Georgina, Copeland, Trisha, Clar, Allison, Mora, Samia, Moorthy, M Vinayaga, Sarkissian, Ara, Carrick, William R, and Anderson, Garnet L
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- 2022
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112. Multivitamins in the prevention of cancer and cardiovascular disease: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
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Sesso, Howard D, Rist, Pamela M, Aragaki, Aaron K, Rautiainen, Susanne, Johnson, Lisa G, Friedenberg, Georgina, Copeland, Trisha, Clar, Allison, Mora, Samia, Moorthy, M Vinayaga, Sarkissian, Ara, Wactawski-Wende, Jean, Tinker, Lesley F, Carrick, William R, Anderson, Garnet L, and Manson, JoAnn E
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- 2022
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113. The R2D2 Prior for Generalized Linear Mixed Models.
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Yanchenko, Eric, Bondell, Howard D., and Reich, Brian J.
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BETA distribution , *BAYESIAN analysis , *RANDOM effects model , *DEFAULT (Finance) - Abstract
In Bayesian analysis, the selection of a prior distribution is typically done by considering each parameter in the model. While this can be convenient, in many scenarios it may be desirable to place a prior on a summary measure of the model instead. In this work, we propose a prior on the model fit, as measured by a Bayesian coefficient of determination ( R 2) , which then induces a prior on the individual parameters. We achieve this by placing a beta prior on R2 and then deriving the induced prior on the global variance parameter for generalized linear mixed models. We derive closed-form expressions in many scenarios and present several approximation strategies when an analytic form is not possible and/or to allow for easier computation. In these situations, we suggest approximating the prior by using a generalized beta prime distribution and provide a simple default prior construction scheme. This approach is quite flexible and can be easily implemented in standard Bayesian software. Lastly, we demonstrate the performance of the method on simulated and real-world data, where the method particularly shines in high-dimensional settings, as well as modeling random effects. [ABSTRACT FROM AUTHOR]
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- 2025
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114. Associations of Vitamin D-Related Biomarkers With Hypertension and the Renin–Angiotensin System in Men and Women.
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Wang, Lu, Cook, Nancy R, Manson, JoAnn E, Gaziano, J Michael, Buring, Julie E, and Sesso, Howard D
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HYPERTENSION in women ,HYPERTENSION risk factors ,MIDDLE-aged men ,OLDER men ,VITAMIN D - Abstract
BACKGROUND Vitamin D may prevent the development of hypertension through down-regulation of renin–angiotensin system. However, epidemiologic studies assessing the interrelation of vitamin D-related biomarkers with hypertension are sparse. METHODS We examined the prospective associations between vitamin D-related biomarkers and the risk of hypertension in a nested case-control study. In each of the Women's Health Study (WHS) and Physicians' Health Study (PHS) II, 500 incident hypertension cases and 500 age and race-matched controls were randomly selected. Baseline plasma 25(OH)-vitamin D [25(OH)D], parathyroid hormone (PTH), and total renin concentrations were measured. RESULTS Among controls, 25(OH)D and PTH were inversely correlated, but neither was correlated with total renin. In the crude model, there was a trend of association between increasing quintiles of 25(OH)D and lower risk of hypertension in women, with relative risks and 95% CIs of 1.00, 1.24 (0.84–1.83), 0.82 (0.53–1.25), 0.75 (0.48–1.16), and 0.81 (0.52–1.27) (P , trend:.07). Adjustment for body mass index and other hypertension risk factors eliminated this association (relative risk of 5th quintile: 1.03). No associations were found in men. Baseline PTH and ratio of 25(OH)D to PTH were not associated with the risk of hypertension in women or men. When men and women were included in the same model, vitamin D insufficiency (defined as 25(OH)D <20 ng/mL) also was not associated with an increased risk of hypertension. No interactions were found across subgroups. CONCLUSIONS Our study found no association of baseline plasma 25(OH)D or PTH with the risk of hypertension or total renin concentration in middle-aged and older men and women. [ABSTRACT FROM AUTHOR]
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- 2024
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115. Design and baseline characteristics of participants in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS)
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Rist, Pamela M., Sesso, Howard D., Johnson, Lisa G., Aragaki, Aaron K., Wang, Lu, Rautiainen, Susanne, Hazra, Aditi, Tobias, Deirdre K., LeBoff, Meryl S., Schroeter, Hagen, Friedenberg, Georgina, Copeland, Trisha, Clar, Allison, Tinker, Lesley F., Hunt, Rebecca P., Bassuk, Shari S., Sarkissian, Ara, Smith, Douglas C., Pereira, Eduardo, Carrick, William R., Wion, Emily S., Schoenberg, Jennifer, Anderson, Garnet L., and Manson, JoAnn E.
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- 2022
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116. Computer-aided segmentation on MRI for prostate radiotherapy, part II: Comparing human and computer observer populations and the influence of annotator variability on algorithm variability
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Sanders, Jeremiah W., Mok, Henry, Hanania, Alexander N., Venkatesan, Aradhana M., Tang, Chad, Bruno, Teresa L., Thames, Howard D., Kudchadker, Rajat J., and Frank, Steven J.
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- 2022
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117. Computer-aided segmentation on MRI for prostate radiotherapy, Part I: Quantifying human interobserver variability of the prostate and organs at risk and its impact on radiation dosimetry
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Sanders, Jeremiah W., Mok, Henry, Hanania, Alexander N., Venkatesan, Aradhana M., Tang, Chad, Bruno, Teresa L., Thames, Howard D., Kudchadker, Rajat J., and Frank, Steven J.
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- 2022
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118. Effect of subscapularis repair in patients with an intact rotator cuff undergoing reverse total shoulder arthroplasty
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Harries, Luke W., Roche, Christopher P., Routman, Howard D., Friedman, Richard J., and Donaldson, Oliver W.
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- 2022
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119. The structure of the native cardiac thin filament at systolic Ca 2+ levels
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Risi, Cristina M., Pepper, Ian, Belknap, Betty, Landim-Vieira, Maicon, White, Howard D., Dryden, Kelly, Pinto, Jose R., Chase, P. Bryant, and Galkin, Vitold E.
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- 2021
120. PURE Biomanufacturing: Secure, Pandemic-Adaptive Biomanufacturing.
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Howard D. Grimes, Gabriela F. Ciocarlie, Bo Yu 0020, Duminda Wijesekera, Gregory E. Shannon, Wayne Austad, Charles Fracchia, Dongyan Xu, Thomas R. Kurfess, Lisa Strama, Michael Mylrea, and Bill Reid
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- 2022
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121. Expression of IGF/insulin receptor in prostate cancer tissue and progression to lethal disease
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Ahearn, Thomas U, Peisch, Sam, Pettersson, Andreas, Ebot, Ericka M, Zhou, Cindy Ke, Graff, Rebecca E, Sinnott, Jennifer A, Fazli, Ladan, Judson, Gregory L, Bismar, Tarek A, Rider, Jennifer R, Gerke, Travis, Chan, June M, Fiorentino, Michelangelo, Flavin, Richard, Sesso, Howard D, Finn, Stephen, Giovannucci, Edward L, Gleave, Martin, Loda, Massimo, Li, Zhe, Pollak, Michael, and Mucci, Lorelei A
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Clinical Research ,Aging ,Prostate Cancer ,Diabetes ,Urologic Diseases ,Cancer ,2.1 Biological and endogenous factors ,Aetiology ,Aged ,Apoptosis ,Biomarkers ,Tumor ,Cell Proliferation ,Disease Progression ,Gene Expression Regulation ,Neoplastic ,Humans ,Insulin ,Insulin-Like Growth Factor I ,Male ,Oncogene Proteins ,Fusion ,Prostatic Neoplasms ,Receptor ,IGF Type 1 ,Receptor ,Insulin ,Receptors ,Somatomedin ,Signal Transduction ,Transcriptional Regulator ERG ,Transdisciplinary Prostate Cancer Partnership ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Circulating insulin-like growth factor-1 (IGF-1) is consistently associated with prostate cancer risk. IGF-1 binds to IGF-1 receptor (IGF1R) and insulin receptor (IR), activating cancer hallmark pathways. Experimental evidence suggests that TMPRSS2:ERG may interact with IGF/insulin signaling to influence progression. We investigated IGF1R and IR expression and its association with lethal prostate cancer among 769 men. Protein expression of IGF1R, IR and ERG (i.e. a surrogate of ERG fusion genes) were assayed by immunohistochemistry. Cox models estimated hazard ratios (HR) and 95% confidence intervals (CI) adjusted for clinical characteristics. Among patients, 29% had strong tumor IGF1R expression and 10% had strong IR expression. During a mean follow-up of 13.2 years through 2012, 80 men (11%) developed lethal disease. Tumors with strong IGF1R or IR expression showed increased cell proliferation, decreased apoptosis and a higher prevalence of ERG. In multivariable models, strong IGF1R was associated with a borderline increased risk of lethal prostate cancer (HR 1.7; 95% CI 0.9-3.1). The association appeared greater in ERG-positive tumors (HR 2.8; 95% CI 0.9-8.4) than in ERG-negative tumors (HR 1.3; 95% CI 0.6-3.0, p-heterogeneity 0.08). There was no association between IR and lethal prostate cancer (HR 0.8; 95% CI 0.4-1.9). These results suggest that tumor IGF1R expression may play a role in prostate cancer progression to a lethal phenotype and that ERG-positive tumors may be more sensitive to IGF signaling. These data may improve our understanding of IGF signaling in prostate cancer and suggest therapeutic options for disease subtypes.
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- 2018
122. Natural History of Cervical Intraepithelial Neoplasia-2 in HIV-Positive Women of Reproductive Age
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Colie, Christine, Michel, Katherine G, Massad, Leslie S, Wang, Cuiwei, DʼSouza, Gypsyamber, Rahangdale, Lisa, Flowers, Lisa, Milam, Joel, Palefsky, Joel M, Minkoff, Howard, Strickler, Howard D, and Kassaye, Seble G
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Infectious Diseases ,HIV/AIDS ,Sexually Transmitted Infections ,Women's Health ,Clinical Research ,Cervical Cancer ,Cancer ,Infection ,Adolescent ,Adult ,Biopsy ,Disease Progression ,Female ,HIV Infections ,Humans ,Longitudinal Studies ,Middle Aged ,Prospective Studies ,Uterine Cervical Neoplasms ,Young Adult ,Uterine Cervical Dysplasia ,cervical intraepithelial neoplasia ,cervix ,disease progression ,HIV ,antiretroviral therapy ,CD4 lymphocyte count ,prospective studies ,cohort studies ,Clinical Sciences ,Public Health and Health Services ,Virology ,Clinical sciences ,Epidemiology ,Public health - Abstract
ObjectiveTo evaluate the natural history of treated and untreated cervical intraepithelial neoplasia-2 (CIN2) among HIV-positive women.MethodsParticipants were women enrolled in the Women's Interagency HIV Study between 1994 and 2013. One hundred four HIV-positive women diagnosed with CIN2 before age 46 were selected, contributing 2076 visits over a median of 10 years (interquartile range 5-16). The outcome of interest was biopsy-confirmed CIN2 progression, defined as CIN3 or invasive cervical cancer. CIN2 treatment was abstracted from medical records.ResultsMost women were African American (53%), current smokers (53%), and had a median age of 33 years at CIN2 diagnosis. Among the 104 HIV-positive women, 62 (59.6%) did not receive CIN2 treatment. Twelve HIV-positive women (11.5%) showed CIN2 progression to CIN3; none were diagnosed with cervical cancer. There was no difference in the median time to progression between CIN2-treated and CIN2-untreated HIV-positive women (2.9 vs. 2.7 years, P = 0.41). CIN2 treatment was not associated with CIN2 progression in multivariate analysis (adjusted hazard ratio 1.82; 95% confidence interval: 0.54 to 7.11), adjusting for combination antiretroviral therapy and CD4 T-cell count. In HIV-positive women, each increase of 100 CD4 T cells was associated with a 33% decrease in CIN2 progression (adjusted hazard ratio 0.67; 95% confidence interval: 0.47 to 0.88), adjusting for CIN2 treatment and combination antiretroviral therapy.ConclusionsCIN2 progression is uncommon in this population, regardless of CIN2 treatment. Additional studies are needed to identify factors to differentiate women at highest risk of CIN2 progression.
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- 2018
123. Methylation of High-Risk Human Papillomavirus Genomes are Associated with Cervical Precancer in HIV-positive Women
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Gradissimo, Ana, Lam, Jessica, Attonito, John D, Palefsky, Joel, Massad, L Stewart, Xie, Xianhong, Eltoum, Isam-Eldin, Rahangdale, Lisa, Fischl, Margaret A, Anastos, Kathryn, Minkoff, Howard, Xue, Xiaonan, D'Souza, Gypsyamber, Flowers, Lisa C, Colie, Christine, Shrestha, Sadeep, Hessol, Nancy A, Strickler, Howard D, and Burk, Robert D
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Women's Health ,Clinical Research ,Human Genome ,Infectious Diseases ,Cancer ,Sexually Transmitted Infections ,HIV/AIDS ,Clinical Trials and Supportive Activities ,Genetics ,Cervical Cancer ,Infection ,Adult ,Case-Control Studies ,Female ,Genomics ,HIV Infections ,Humans ,Methylation ,Papillomavirus Infections ,Risk Factors ,Medical and Health Sciences ,Epidemiology ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundHIV-positive women are at substantial risk of HPV-associated cervical neoplasia caused by high-risk (HR) HPVs. Methylation of the HPV genome is associated with cervical intraepithelial neoplasia grade 3 (CIN3) in HIV-negative women, yet it is unknown whether this holds true for HIV-positive women.MethodsWe designed a case-control study within the Women's Interagency HIV Study (WIHS) cohort comparing HIV-positive CIN3 cases (N = 72) to HIV-positive controls without detectable CIN2+. The unit of analysis and matching was HPV-type infection. Cases with ≥2 HR-HPV types (N = 23; 32%) had a separate control for each HR-HPV type. We developed and utilized next-generation sequencing (NGS) methylation assays for 12 different HR-HPVs, focusing on CpG sites in the L1/L2 regions.ResultsSignificant case-control differences in individual CpG site methylation levels were observed for multiple alpha-9 (HPV16/31/35/58) and alpha-7 HPV (HPV18/39/45) types, based on dichotomization of tertile levels (T3 vs. T1 and T2). Analyses combining homologous CpG sites [e.g., HPV16-L1-5608/HPV31-L1-5521/HPV35-L2L1-5570; OR = 7.28; 95% confidence interval (CI): 2.75-19.3], and (e.g., HPV18-L1-7062/HPV45-L1-7066; OR = 6.94; 95% CI: 1.23-39.3) were significant in separate case-control comparisons. In cases with multiple HR-HPVs, we tested and confirmed the hypothesis that one HR-HPV type would have higher methylation than other types detected, consistent with there being a single HR-HPV causally related to a lesion.ConclusionsCIN3 is associated with elevated L1/L2 CpG methylation levels in HIV-positive women.ImpactHPV DNA CpG methylation is a promising triage option in HIV-positive women testing positive for HR-HPV types and provides risk attribution in women with multiple HPV type infections.
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- 2018
124. Racial differences in human papilloma virus types amongst United States women with HIV and cervical precancer
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Keller, Marla J, Burk, Robert D, Massad, L Stewart, Eltoum, Isam-Eldin, Hessol, Nancy A, Anastos, Kathryn, Xie, Xianhong, Minkoff, Howard, Xue, Xiaonan, Reimers, Laura L, Kuniholm, Mark, DʼSouza, Gypsyamber, Colie, Christine, Aouizerat, Bradley, Palefsky, Joel M, and Strickler, Howard D
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Clinical Research ,Infectious Diseases ,Minority Health ,HIV/AIDS ,Cervical Cancer ,Cancer ,Vaccine Related ,Immunization ,Sexually Transmitted Infections ,Prevention ,Women's Health ,Infection ,Good Health and Well Being ,Adult ,Black or African American ,Cervix Uteri ,Female ,Genotype ,Genotyping Techniques ,HIV Infections ,Humans ,Longitudinal Studies ,Middle Aged ,Papanicolaou Test ,Papillomaviridae ,Papillomavirus Infections ,Polymerase Chain Reaction ,Precancerous Conditions ,Prevalence ,United States ,White People ,cervical precancer ,ethnicity ,HIV ,human papillomavirus ,race ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveRecent studies reported a lower human papillomavirus 16 (HPV16) prevalence in cervical precancer among African American than Caucasian women in the general population. We assessed this relationship in women with HIV.DesignWomen living with or at risk for HIV in the Women's Interagency HIV Study were followed semi-annually with Pap tests, colposcopy/histology (if indicated), and collection of cervicovaginal lavage samples for HPV testing by PCR. Racial and ethnic groups were defined using genomic Ancestry Informative Markers (AIMs).ResultsAmong 175 cases of cervical intraepithelial neoplasia 3 or worse (CIN-3+), 154 were diagnosed in women with HIV. African American (27%) and Hispanic (37%) cases were significantly less likely than Caucasian (62%) women to test positive for HPV16 (P = 0.01). In multivariate logistic regression models, these associations remained significant for African Americans (odds ratio = 0.13; 95% confidence interval (CI) 0.04-0.44; P = 0.001) but not Hispanics, after controlling for HIV status, CD4 count, history of AIDS, age, smoking, and sexual behavior. Limiting the analysis to women with HIV did not change the findings.ConclusionHPV16 prevalence is lower in African American compared with Caucasian women with HIV and cervical precancer, independent of immune status. Future studies to determine why these racial differences exist are warranted, and whether there are similar associations between race and invasive cervical cancer in women with HIV. Further, HPV types not covered by quadrivalent and bivalent vaccines may play an especially important role in cervical precancer among HIV-positive African American women, a possible advantage to using nonavalent HPV vaccine in this population.
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- 2018
125. Regulatory CD4+ T Cells Recognize Major Histocompatibility Complex Class II Molecule–Restricted Peptide Epitopes of Apolipoprotein B
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Kimura, Takayuki, Kobiyama, Kouji, Winkels, Holger, Tse, Kevin, Miller, Jacqueline, Vassallo, Melanie, Wolf, Dennis, Ryden, Christian, Orecchioni, Marco, Dileepan, Thamotharampillai, Jenkins, Marc K, James, Eddie A, Kwok, William W, Hanna, David B, Kaplan, Robert C, Strickler, Howard D, Durkin, Helen G, Kassaye, Seble G, Karim, Roksana, Tien, Phyllis C, Landay, Alan L, Gange, Stephen J, Sidney, John, Sette, Alessandro, and Ley, Klaus
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Biomedical and Clinical Sciences ,Immunology ,Heart Disease ,Immunization ,Aging ,Atherosclerosis ,Vaccine Related ,Cardiovascular ,2.1 Biological and endogenous factors ,Good Health and Well Being ,Adjuvants ,Immunologic ,Animals ,Aorta ,Aortic Diseases ,Apolipoprotein B-100 ,Apolipoproteins B ,Disease Models ,Animal ,Epitope Mapping ,Epitopes ,T-Lymphocyte ,Female ,Freund's Adjuvant ,Histocompatibility Antigens Class II ,Humans ,Lymphocyte Activation ,Male ,Mice ,Mice ,Inbred C57BL ,Mice ,Knockout ,ApoE ,Peptide Fragments ,Plaque ,Atherosclerotic ,T-Lymphocytes ,Regulatory ,Vaccination ,antigen specificity ,apoB-100 ,atherosclerosis ,regulatory T cells ,vaccination ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences ,Sports science and exercise - Abstract
BackgroundCD4+ T cells play an important role in atherosclerosis, but their antigen specificity is poorly understood. Immunization with apolipoprotein B (ApoB, core protein of low density lipoprotein) is known to be atheroprotective in animal models. Here, we report on a human APOB peptide, p18, that is sequence-identical in mouse ApoB and binds to both mouse and human major histocompatibility complex class II molecules.MethodsWe constructed p18 tetramers to detect human and mouse APOB-specific T cells and assayed their phenotype by flow cytometry including CD4 lineage transcription factors, intracellular cytokines, and T cell receptor activation. Apolipoprotein E-deficient ( Apoe-/-) mice were vaccinated with p18 peptide or adjuvants alone, and atherosclerotic burden in the aorta was determined.ResultsIn human peripheral blood mononuclear cells from donors without cardiovascular disease, p18 specific CD4+ T cells detected by a new human leukocyte antigen-antigen D related-p18 tetramers were mostly Foxp3+ regulatory T cells (Tregs). Donors with subclinical cardiovascular disease as detected by carotid artery ultrasound had Tregs coexpressing retinoic acid-related orphan receptor gamma t or T-bet, which were both almost absent in donors without cardiovascular disease. In Apoe-/- mice, immunization with p18 induced Tregs and reduced atherosclerotic lesions. After peptide restimulation, responding CD4+ T cells identified by Nur77-GFP (green fluorescent protein) were highly enriched in Tregs. A new mouse I-Ab-p18 tetramer identified the expansion of p18-specific CD4+ T cells on vaccination, which were enriched for interleukin-10-producing Tregs.ConclusionsThese findings show that APOB p18-specific CD4+ T cells are mainly Tregs in healthy donors, but coexpress other CD4 lineage transcription factors in donors with subclinical cardiovascular disease. This study identifies ApoB peptide 18 as the first Treg epitope in human and mouse atherosclerosis.
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- 2018
126. Improved Prototypical Semi-Supervised Learning with Foundation Models: Prototype Selection, Parametric vMF-SNE Pretraining and Multi-view Pseudolabelling.
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Evelyn J. Mannix and Howard D. Bondell
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- 2023
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127. Cold PAWS: Unsupervised class discovery and the cold-start problem.
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Evelyn J. Mannix and Howard D. Bondell
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- 2023
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128. FedDAG: Federated DAG Structure Learning.
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Erdun Gao, Junjia Chen, Li Shen 0008, Tongliang Liu, Mingming Gong, and Howard D. Bondell
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- 2023
129. Development of a thermal spray coating aerosol generator and inhalation exposure system
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Afshari, Aliakbar A., McKinney, Walter, Cumpston, Jared L., Leonard, Howard D., Cumpston, James B., Meighan, Terence G., Jackson, Mark, Friend, Sherri, Kodali, Vamsi, Lee, Eun Gyung, and Antonini, James M.
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- 2022
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130. Modeling to Evaluate Conventional Procedures
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Stupak, Howard D. and Stupak, Howard D.
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- 2020
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131. Strategies for Addressing Mouth-Breathing Treatment with an 'Adequate' Nose
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Stupak, Howard D. and Stupak, Howard D.
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- 2020
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132. Complementary Procedures to the Framework Strategy (The Canopy Layer)
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Stupak, Howard D. and Stupak, Howard D.
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- 2020
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133. Rhinoplasty Strategy and Tactics Using the Rhinoplasty Compass™
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Stupak, Howard D. and Stupak, Howard D.
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- 2020
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134. A Structural Model to Systematically Understand Nasal Framework: The Rhinoplasty Compass™
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Stupak, Howard D. and Stupak, Howard D.
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- 2020
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135. Breaking the Barriers Between Specialties: Toward a Universal Understanding of Anatomy and Function
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Stupak, Howard D. and Stupak, Howard D.
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- 2020
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136. The Human Facial Skeleton: Influence on the Airway and Aesthetics? An Analysis of Cause/Effect Paradigms
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Stupak, Howard D. and Stupak, Howard D.
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- 2020
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137. The Problem We Face: The 'Compartmentalized' Conventional View of Facial/Nasal Anatomy
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Stupak, Howard D. and Stupak, Howard D.
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- 2020
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138. Nasal Function and Sleep Disorders
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Stupak, Howard D. and Stupak, Howard D.
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- 2020
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139. The Invisible Forces in Our Nasal Airway: Air Flow and Cavity Negative Pressure : Nasal Obstruction Versus Nasal Underuse: Are the Turbinates the Problem or the Solution?
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Stupak, Howard D. and Stupak, Howard D.
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- 2020
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140. molBV reveals immune landscape of bacterial vaginosis and predicts human papillomavirus infection natural history
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Usyk, Mykhaylo, Schlecht, Nicolas F., Pickering, Sarah, Williams, LaShanda, Sollecito, Christopher C., Gradissimo, Ana, Porras, Carolina, Safaeian, Mahboobeh, Pinto, Ligia, Herrero, Rolando, Strickler, Howard D., Viswanathan, Shankar, Nucci-Sack, Anne, Diaz, Angela, and Burk, Robert D.
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- 2022
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141. Negative pressure ventilation protects the brain
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van Rijn, C. M., van Egmond, J., Howard, D., Coulthard, M. G., Perella, P., Roberts, J. H. M., and McKeown, D.
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- 2022
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142. BioSecure Digital Twin: Manufacturing Innovation and Cybersecurity Resilience.
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Michael Mylrea, Charles Fracchia, Howard D. Grimes, Wayne Austad, Gregory E. Shannon, Bill Reid, and Nathan Case
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- 2021
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143. Comprehensive Audiologic Analyses After Cisplatin-Based Chemotherapy
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Sanchez, Victoria A., primary, Dinh, Paul C., additional, Monahan, Patrick O., additional, Althouse, Sandra, additional, Rooker, Jennessa, additional, Sesso, Howard D., additional, Dolan, M. Eileen, additional, Weinzerl, Mandy, additional, Feldman, Darren R., additional, Fung, Chunkit, additional, Einhorn, Lawrence H., additional, Frisina, Robert D., additional, and Travis, Lois B., additional
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- 2024
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144. Quantifying selection on standard metabolic rate and body mass in Drosophila melanogaster
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Videlier, Mathieu, Careau, Vincent, Wilson, Alastair J., and Rundle, Howard D.
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- 2021
145. Development and validation of a predictive model for outcomes in shoulder arthroplasty: a multicenter analysis of nearly 2000 patients
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Baessler, Aaron M., Brolin, Tyler J., Azar, Frederick M., Sen, Saunak, Chang, Michael, Falkner, Dmitri, Zmistowski, Benjamin M., Routman, Howard D., Namdari, Surena, Gulotta, Lawrence V., and Throckmorton, Thomas W.
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- 2021
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146. Prediction of shoreline–shelf depositional process regime guided by palaeotidal modelling
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Collins, Daniel S., Avdis, Alexandros, Wells, Martin R., Dean, Christopher D., Mitchell, Andrew J., Allison, Peter A., Johnson, Howard D., Hampson, Gary J., Hill, Jon, and Piggott, Matthew D.
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- 2021
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147. Development time mediates the effect of larval diet on ageing and mating success of male antler flies in the wild
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Angell, Christopher S., Oudin, Mathieu J., Rode, Nicolas O., Mautz, Brian S., Bonduriansky, Russell, and Rundle, Howard D.
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- 2020
148. Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design.
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Leora I Horwitz, Tanayott Thaweethai, Shari B Brosnahan, Mine S Cicek, Megan L Fitzgerald, Jason D Goldman, Rachel Hess, S L Hodder, Vanessa L Jacoby, Michael R Jordan, Jerry A Krishnan, Adeyinka O Laiyemo, Torri D Metz, Lauren Nichols, Rachel E Patzer, Anisha Sekar, Nora G Singer, Lauren E Stiles, Barbara S Taylor, Shifa Ahmed, Heather A Algren, Khamal Anglin, Lisa Aponte-Soto, Hassan Ashktorab, Ingrid V Bassett, Brahmchetna Bedi, Nahid Bhadelia, Christian Bime, Marie-Abele C Bind, Lora J Black, Andra L Blomkalns, Hassan Brim, Mario Castro, James Chan, Alexander W Charney, Benjamin K Chen, Li Qing Chen, Peter Chen, David Chestek, Lori B Chibnik, Dominic C Chow, Helen Y Chu, Rebecca G Clifton, Shelby Collins, Maged M Costantine, Sushma K Cribbs, Steven G Deeks, John D Dickinson, Sarah E Donohue, Matthew S Durstenfeld, Ivette F Emery, Kristine M Erlandson, Julio C Facelli, Rachael Farah-Abraham, Aloke V Finn, Melinda S Fischer, Valerie J Flaherman, Judes Fleurimont, Vivian Fonseca, Emily J Gallagher, Jennifer C Gander, Maria Laura Gennaro, Kelly S Gibson, Minjoung Go, Steven N Goodman, Joey P Granger, Frank L Greenway, John W Hafner, Jenny E Han, Michelle S Harkins, Kristine S P Hauser, James R Heath, Carla R Hernandez, On Ho, Matthew K Hoffman, Susan E Hoover, Carol R Horowitz, Harvey Hsu, Priscilla Y Hsue, Brenna L Hughes, Prasanna Jagannathan, Judith A James, Janice John, Sarah Jolley, S E Judd, Joy J Juskowich, Diane G Kanjilal, Elizabeth W Karlson, Stuart D Katz, J Daniel Kelly, Sara W Kelly, Arthur Y Kim, John P Kirwan, Kenneth S Knox, Andre Kumar, Michelle F Lamendola-Essel, Margaret Lanca, Joyce K Lee-Lannotti, R Craig Lefebvre, Bruce D Levy, Janet Y Lin, Brian P Logarbo, Jennifer K Logue, Michele T Longo, Carlos A Luciano, Karen Lutrick, Shahdi K Malakooti, Gail Mallett, Gabrielle Maranga, Jai G Marathe, Vincent C Marconi, Gailen D Marshall, Christopher F Martin, Jeffrey N Martin, Heidi T May, Grace A McComsey, Dylan McDonald, Hector Mendez-Figueroa, Lucio Miele, Murray A Mittleman, Sindhu Mohandas, Christian Mouchati, Janet M Mullington, Girish N Nadkarni, Erica R Nahin, Robert B Neuman, Lisa T Newman, Amber Nguyen, Janko Z Nikolich, Igho Ofotokun, Princess U Ogbogu, Anna Palatnik, Kristy T S Palomares, Tanyalak Parimon, Samuel Parry, Sairam Parthasarathy, Thomas F Patterson, Ann Pearman, Michael J Peluso, Priscilla Pemu, Christian M Pettker, Beth A Plunkett, Kristen Pogreba-Brown, Athena Poppas, J Zachary Porterfield, John G Quigley, Davin K Quinn, Hengameh Raissy, Candida J Rebello, Uma M Reddy, Rebecca Reece, Harrison T Reeder, Franz P Rischard, Johana M Rosas, Clifford J Rosen, Nadine G Rouphael, Dwight J Rouse, Adam M Ruff, Christina Saint Jean, Grecio J Sandoval, Jorge L Santana, Shannon M Schlater, Frank C Sciurba, Caitlin Selvaggi, Sudha Seshadri, Howard D Sesso, Dimpy P Shah, Eyal Shemesh, Zaki A Sherif, Daniel J Shinnick, Hyagriv N Simhan, Upinder Singh, Amber Sowles, Vignesh Subbian, Jun Sun, Mehul S Suthar, Larissa J Teunis, John M Thorp, Amberly Ticotsky, Alan T N Tita, Robin Tragus, Katherine R Tuttle, Alfredo E Urdaneta, P J Utz, Timothy M VanWagoner, Andrew Vasey, Suzanne D Vernon, Crystal Vidal, Tiffany Walker, Honorine D Ward, David E Warren, Ryan M Weeks, Steven J Weiner, Jordan C Weyer, Jennifer L Wheeler, Sidney W Whiteheart, Zanthia Wiley, Natasha J Williams, Juan P Wisnivesky, John C Wood, Lynn M Yee, Natalie M Young, Sokratis N Zisis, and Andrea S Foulkes
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Medicine ,Science - Abstract
ImportanceSARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are ill-defined. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC in Adults (RECOVER-Adult) are to: (1) characterize PASC prevalence; (2) characterize the symptoms, organ dysfunction, natural history, and distinct phenotypes of PASC; (3) identify demographic, social and clinical risk factors for PASC onset and recovery; and (4) define the biological mechanisms underlying PASC pathogenesis.MethodsRECOVER-Adult is a combined prospective/retrospective cohort currently planned to enroll 14,880 adults aged ≥18 years. Eligible participants either must meet WHO criteria for suspected, probable, or confirmed infection; or must have evidence of no prior infection. Recruitment occurs at 86 sites in 33 U.S. states, Washington, DC and Puerto Rico, via facility- and community-based outreach. Participants complete quarterly questionnaires about symptoms, social determinants, vaccination status, and interim SARS-CoV-2 infections. In addition, participants contribute biospecimens and undergo physical and laboratory examinations at approximately 0, 90 and 180 days from infection or negative test date, and yearly thereafter. Some participants undergo additional testing based on specific criteria or random sampling. Patient representatives provide input on all study processes. The primary study outcome is onset of PASC, measured by signs and symptoms. A paradigm for identifying PASC cases will be defined and updated using supervised and unsupervised learning approaches with cross-validation. Logistic regression and proportional hazards regression will be conducted to investigate associations between risk factors, onset, and resolution of PASC symptoms.DiscussionRECOVER-Adult is the first national, prospective, longitudinal cohort of PASC among US adults. Results of this study are intended to inform public health, spur clinical trials, and expand treatment options.RegistrationNCT05172024.
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- 2023
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149. Bayesian Regression Using a Prior on the Model Fit: The R2-D2 Shrinkage Prior
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Zhang, Yan Dora, Naughton, Brian P., Bondell, Howard D., and Reich, Brian J.
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Statistics - Methodology - Abstract
Prior distributions for high-dimensional linear regression require specifying a joint distribution for the unobserved regression coefficients, which is inherently difficult. We instead propose a new class of shrinkage priors for linear regression via specifying a prior first on the model fit, in particular, the coefficient of determination, and then distributing through to the coefficients in a novel way. The proposed method compares favourably to previous approaches in terms of both concentration around the origin and tail behavior, which leads to improved performance both in posterior contraction and in empirical performance. The limiting behavior of the proposed prior is $1/x$, both around the origin and in the tails. This behavior is optimal in the sense that it simultaneously lies on the boundary of being an improper prior both in the tails and around the origin. None of the existing shrinkage priors obtain this behavior in both regions simultaneously. We also demonstrate that our proposed prior leads to the same near-minimax posterior contraction rate as the spike-and-slab prior.
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- 2016
150. Multifocal Pyloric Gland Adenoma of the Esophagus Treated by Circumferential Endoscopic Submucosal Dissection
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Lee, Howard D., Magulick, John P., and Quiles, John G.
- Published
- 2023
- Full Text
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