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101. Switch-maintenance avelumab immunotherapy following first-line chemotherapy for patients with advanced, unresectable or metastatic urothelial carcinoma: the first Japanese real-world evidence from a multicenter study.

Author

Miyake, Makito, Shimizu, Takuto, Oda, Yuki, Tachibana, Akira, Ohmori, Chihiro, Itami, Yoshitaka, Kiba, Keisuke, Tomioka, Atsushi, Yamamoto, Hiroaki, Ohnishi, Kenta, Nishimura, Nobutaka, Hori, Shunta, Morizawa, Yosuke, Gotoh, Daisuke, Nakai, Yasushi, Torimoto, Kazumasa, Fujii, Tomomi, Tanaka, Nobumichi, and Fujimoto, Kiyohide

Published
2023
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102. Clinical significance of limited and extended pelvic lymph node dissection during robot‐assisted radical prostatectomy for patients with localized prostate cancer: A retrospective, propensity score matching analysis.

Author

Hori, Shunta, Nakai, Yasushi, Tachibana, Akira, Omori, Chihiro, Nishimura, Nobutaka, Inoue, Kuniaki, Tomizawa, Mitsuru, Shimizu, Takuto, Morizawa, Yosuke, Gotoh, Daisuke, Miyake, Makito, Torimoto, Kazumasa, Yoneda, Tatsuo, Fujimoto, Kiyohide, and Tanaka, Nobumichi

Subjects
*LYMPHADENECTOMY, *PROSTATE cancer, *PROPENSITY score matching, *RADICAL prostatectomy, *PROSTATE cancer patients, *SURGICAL robots
Abstract

Objectives: We investigated the diagnostic and therapeutic benefits of limited or extended pelvic lymph node dissection during a robot‐assisted radical prostatectomy for localized prostate cancer. Methods: Diagnostic and therapeutic benefits were assessed according to the rates of pN1 and biochemical recurrence, respectively. The primary outcome was the biochemical recurrence‐free rate, and secondary outcomes included the diagnostic and therapeutic benefits of pelvic lymph node dissection. Results: A total of 534 patients were analyzed. Out of the 534 patients, 207 (38.8%) received limited pelvic lymph node dissection while 134 (25.1%) received extended dissection. There were 297 patients with a Briganti index ≥5%. Extended dissections yielded significantly more resected lymph nodes (p < 0.0001), and 72.2% of cases of pN1 were located outside the obturator. The incidence rate of pN1 was 6.1%, and performance of extended lymph node dissection was an independent predictor for pN1 (odds ratio 9.0, 95% confidence interval 2.5–33.1). The rate of biochemical recurrence was 14.9%, and Cox proportional hazards regression analysis of the propensity score matched population revealed that patients with high or very‐high risk tended to benefit from limited lymph node dissection (hazard ratio 8.4, 95% confidence interval 0.8–82.3) while the therapeutic benefit of extended dissection was unclear by comparison. Conclusions: Extended pelvic lymph node dissection significantly improves diagnostic accuracy; however, the therapeutic benefit of pelvic lymph node dissection was not observed in this study. [ABSTRACT FROM AUTHOR]

Published
2023
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103. Life sciences

Author

Iwamoto, Takashi, Torimoto, Kazumasa, Gotoh, Daisuke, Onishi, Sayuri, Hori, Shunta, Morizawa, Yousuke, Nakai, Yasushi, Miyake, Makito, and Fujimoto, Kiyohide

Subjects
Inbred Dahl rats, Circadian rhythm, Polyuria, Clock gene, Nocturia
Abstract

Aims: To examine the circadian expression changes in bladder clock genes in Dahl salt-sensitive rats following high salt intake. Main methods: Eighteen rats were divided into three groups: the high-salt diet group (HS group), the normal-salt diet group (NS group), and the salt-load interruption group (from a 4 % salt diet to a normal diet; salt-load interruption group [SI group]). Each rat was placed in an individual metabolic cage for 24 h twice weekly. Water intake, urine production, voiding frequency, and voided volume per micturition were recorded. Furthermore, 108 control rats were prepared. Bladders were harvested every 4 h at six time points. Furthermore, the mRNA expression of clock genes and mechanosensors was analyzed. Key findings: In the HS group, the bladder clock genes showed lower mRNA levels than in the NS group. The amplitude of circadian expression changes in bladder clock genes in the HS group was lower than that in the NS group. However, after changing from a 4 % salt diet to a normal diet, the waveforms of the clock gene expression in the SI group were closer to those of the NS group. The 24-h water intake and urinary volume of the SI group decreased to levels comparable to those of the NS group. Significance: Reduced salt intake partially restored the circadian rhythms of bladder clock genes., 博士（医学）・甲第857号・令和4年12月22日, Copyright © 2022 Elsevier Inc. All rights reserved.

Published
2022

106. Usefulness of clinical factors for diagnosing and differentiating types of testicular malposition in boys: A retrospective study

Author

Hori, Shunta, primary, Aoki, Katsuya, additional, Tachibana, Akira, additional, Nishimura, Nobutaka, additional, Tomizawa, Mitsuru, additional, Morizawa, Yosuke, additional, Gotoh, Daisuke, additional, Fukui, Shinji, additional, Nakai, Yasushi, additional, Miyake, Makito, additional, Torimoto, Kazumasa, additional, Yoneda, Tatsuo, additional, Tanaka, Nobumichi, additional, and Fujimoto, Kiyohide, additional

Published
2021
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107. Video‐urodynamic effects of vibegron, a new selective β3‐adrenoceptor agonist, on antimuscarinic‐resistant neurogenic bladder dysfunction in patients with spina bifida

Author

Aoki, Katsuya, primary, Momose, Hitoshi, additional, Gotoh, Daisuke, additional, Morizawa, Yosuke, additional, Hori, Shunta, additional, Nakai, Yasushi, additional, Miyake, Makito, additional, Anai, Satoshi, additional, Torimoto, Kazumasa, additional, Tanaka, Nobumichi, additional, Yoneda, Tatsuo, additional, Matsumoto, Yoshihiro, additional, and Fujimoto, Kiyohide, additional

Published
2021
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108. Prognostic impact of tumor-infiltrating CD276/Foxp3-positive lymphocytes and associated circulating cytokines in patients undergoing radical nephrectomy for localized renal cell carcinoma

Author

Iida, Kota, Miyake, Makito, Onishi, Kenta, Hori, Shunta, Morizawa, Yosuke, Gotoh, Daisuke, Itami, Yoshitaka, Onishi, Sayuri, Nakai, Yasushi, Anai, Satoshi, Tanaka, Nobumichi, and Fujimoto, Kiyohide

Subjects
renal cell carcinoma, cluster of differentiation 276, Foxp3, tumor‑infiltrating lymphocyte, cytokine, hemic and immune systems, chemical and pharmacologic phenomena
Abstract

Renal cell carcinoma (RCC) is an immunogenic tumor and pathological specimen generally contain large quantities of tumor-infiltrating lymphocytes (TILs). Numerous cell types and cytokines could affect the immune escape mechanism of tumor cells. The aim of the present study was to investigate the prognostic impact of TILs and the associated circulating cytokines on localized clear cell RCC following radical nephrectomy. A total of 87 patients who had undergone radical nephrectomy and were pathologically diagnosed with localized clear cell RCC were included. The present study evaluated the profile of TILs with immunohistochemical analysis of tumor specimens using a panel of antibodies [cluster of differentiation (CD)-4, CD8, CD80, CD86, CD276, and Forkhead box p3 (Foxp3)]. Counts of each TIL were compared with clinicopathological variables. Based on the results of immunohistochemical analyses, putative cytokines, including interleukin (IL)-6, IL-10, IL-17, interferon-γ, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β, were selected, and their levels in preoperative serum were measured by ELISA. The levels were compared with TIL counts in tumor specimens. High counts of the CD276+ and Foxp3+ TILs were identified as independent factors for poor prognosis for metastasis and local recurrence following radical nephrectomy (P=0.033 and 0.006, respectively). A high CD276+ TIL count was associated with preoperative serum levels of TNF-α and IFN-γ (P=0.027 and P=0.035, respectively), whereas a high count of Foxp3+ TILs was associated with preoperative serum levels of TGF-β (P=0.021). High levels of TNF-α and TGF-β were associated with recurrence-free survival (P=0.035 and P=0.031, respectively). Topical intra-tumoral immunoreaction and systemic immune status may be associated with patients with localized RCC. The topical induction of the CD276+ and Foxp3+ TILs was suggested to be associated with high levels of serum TNF-α and IFN-γ. Preoperative serum levels of TNF-α and TGF-β could be simple and non-invasive biomarkers for risk stratification before radical surgery., 博士（医学）・甲第741号・令和2年3月16日, Copyright © Spandidos Publications 2019. All rights reserved., Articles from Oncology Letters are provided here courtesy of Spandidos Publications.

Published
2019

109. Trends in primary treatment for localized prostate cancer according to the availability of treatment modalities and the impact of introducing robotic surgery.

Author

Hori, Shunta, Nakai, Yasushi, Tomizawa, Mitsuru, Morizawa, Yosuke, Gotoh, Daisuke, Miyake, Makito, Anai, Satoshi, Torimoto, Kazumasa, Yoneda, Tatsuo, Fujimoto, Kiyohide, and Tanaka, Nobumichi

Subjects
*SURGICAL robots, *PROSTATE cancer, *RADICAL prostatectomy, *ANDROGEN deprivation therapy, *PROSTATE cancer patients, *RETROPUBIC prostatectomy
Abstract

Objectives: We aimed to investigate the effect of available treatment modalities on primary treatment selection in patients with localized prostate cancer and that of introducing robotic surgery. Methods: We retrospectively studied 12 061 patients diagnosed with localized prostate cancer between 2004 and 2018 from 21 institutions. These institutions were divided into five groups according to the availability of surgery and radiotherapy. Differences in primary treatment selection between the institutions were investigated, and the predictive factors involved in the selection were explored. Results: Surgery, radiotherapy, androgen deprivation therapy, and active surveillance/watchful waiting were selected as primary treatment in 4115, 3621, 3188, and 821 patients, respectively, while the remaining 316 patients selected other modalities. The number of patients, particularly young patients, was much higher in institutions with both surgery and radiotherapy. With the introduction of robotic surgery, open radical prostatectomy has decreased, and robotic surgery made up approximately 70% of all prostatectomies. Institutions with both surgery and radiotherapy tended to treat patients with very low or low risk by surgery or radiotherapy, while institutions without surgery and radiotherapy tended to select active surveillance or watchful waiting. Multivariate analysis revealed that primary treatment selection for prostate cancer was affected not only by clinical factors, but also by the available modalities in each institution. Conclusions: Differences in available treatment modalities affect the selection of primary treatment for localized prostate cancer. Introduction of robotic surgery also has a strong influence on the number of patients in each institution. [ABSTRACT FROM AUTHOR]

Published
2022
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110. Assessment of bladder function for stabilizing urinary volume overnight with recording of brain waves ( ABSORB study)

Author

Torimoto, Kazumasa, primary, Matsushita, Chie, additional, Itami, Yoshitaka, additional, Iwamoto, Takashi, additional, Owari, Takuya, additional, Gotoh, Daisuke, additional, Miyake, Makito, additional, Hori, Shunta, additional, Nakai, Yasushi, additional, Aoki, Katsuya, additional, Hirao, Shuya, additional, Momose, Hitoshi, additional, Tanaka, Nobumichi, additional, and Fujimoto, Kiyohide, additional

Published
2021
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112. Intravesical Bacillus Calmette-Guerin treatment-induced sleep quality deterioration in patients with non-muscle invasive bladder cancer: functional outcome assessment based on a questionnaire survey and actigraphy

Author

Miyake, Makito, primary, Nishimura, Nobutaka, additional, Oda, Yuki, additional, Owari, Takuya, additional, Hori, Shunta, additional, Morizawa, Yosuke, additional, Gotoh, Daisuke, additional, Nakai, Yasushi, additional, Anai, Satoshi, additional, Torimoto, Kazumasa, additional, Aoki, Katsuya, additional, Yoneda, Tatsuo, additional, Fujii, Tomomi, additional, Tanaka, Nobumichi, additional, and Fujimoto, Kiyohide, additional

Published
2021
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114. Trends in risk classification at diagnosis and choice of primary therapy for prostate cancer: An analysis of 10 839 patients from the Nara Urological Research and Treatment Group registry between 2004 and 2015

Author

Nakai, Yasushi, primary, Tanaka, Nobumichi, additional, Fujii, Tomomi, additional, Miyake, Makito, additional, Anai, Satoshi, additional, Hori, Shunta, additional, Shimizu, Takuto, additional, Onishi, Mikiko, additional, Ichikawa, Kazuki, additional, Onishi, Kenta, additional, and Fujimoto, Kiyohide, additional

Published
2021
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116. Additional file 1 of Remnant renal volume can predict prognosis of remnant renal function in kidney transplantation donors: a prospective observational study

Author

Hori, Shunta, Tanaka, Nobumichi, Yoneda, Tatsuo, Nishimura, Nobutaka, Tomizawa, Mitsuru, Nakahama, Tomonori, Nakai, Yasushi, Miyake, Makito, Torimoto, Kazumasa, Minamiguchi, Kiyoyuki, and Fujimoto, Kiyohide

Abstract

Additional file 1 : Table S1. Clavien classification of surgical complications.

Published
2021
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117. This title is unavailable for guests, please login to see more information.

Author

ODA, Yuki, HORI, Shunta, NISHIMURA, Nobutaka, YOSHIDA, Takanori, UEMATSU, Toshitaka, OHMORI, Chihiro, MIYAKE, Makito, ANAI, Satoshi, TORIMOTO, Kazumasa, AOKI, Katsuya, TANAKA, Nobumichi, YONEDA, Tatsuo, FUJIMOTO, Kiyohide, ODA, Yuki, HORI, Shunta, NISHIMURA, Nobutaka, YOSHIDA, Takanori, UEMATSU, Toshitaka, OHMORI, Chihiro, MIYAKE, Makito, ANAI, Satoshi, TORIMOTO, Kazumasa, AOKI, Katsuya, TANAKA, Nobumichi, YONEDA, Tatsuo, and FUJIMOTO, Kiyohide

Abstract

Patients who contract severe renal infections often suffer from urosepsis. Therefore, early diagnosis and treatment are required. Sometimes, the treatment with antibiotics is not enough for control of the infections. Most of the patients also require surgical interventions including transurethral drainage and nephrectomy. Twenty-two patients with severe renal infections treated between April 2010 and October 2019 at our institute were evaluated retrospectively. Eleven patients had undergone nephrectomy. Open nephrectomy was performed on 10 patients. Laparoscopic nephrectomy was attempted in the other patient but was converted to open nephrectomy because severe adhesion was found around the tissues. Nephrectomy was performed by the retroperitoneal approach on 9 patients and by the transperitoneal approach on 2 patients. The reteroperitoneal approach was used on two patients who suffered postoperative colon perforation. Inflammatory involvement of renal pelvis, hilum and adjacent structures leads to dense fibrotic reaction and obliteration of tissue planes, which makes the nephrectomy procedure challenging. Therefore, it is important to choose the most appropriate nephrectomy procedure for each patient when they have contracted severe renal infections.

Published
2021

119. Intravesical Bacillus Calmette–Guérin Treatment for T1 High-Grade Non-Muscle Invasive Bladder Cancer with Divergent Differentiation or Variant Morphologies

Author

Miyake, Makito, primary, Nishimura, Nobutaka, additional, Iida, Kota, additional, Fujii, Tomomi, additional, Nishikawa, Ryoma, additional, Teraoka, Shogo, additional, Takenaka, Atsushi, additional, Kikuchi, Hiroshi, additional, Abe, Takashige, additional, Shinohara, Nobuo, additional, Okajima, Eijiro, additional, Shimizu, Takuto, additional, Hori, Shunta, additional, Tsuchiya, Norihiko, additional, Owari, Takuya, additional, Murakami, Yasukiyo, additional, Taoka, Rikiya, additional, Kobayashi, Takashi, additional, Kojima, Takahiro, additional, Nishiyama, Naotaka, additional, Kitamura, Hiroshi, additional, Nishiyama, Hiroyuki, additional, and Fujimoto, Kiyohide, additional

Published
2021
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120. Hexylaminolevulinate‐mediated fluorescent urine cytology with a novel automated detection technology for screening and surveillance of bladder cancer

Author

Miyake, Makito, primary, Nakai, Yasushi, additional, Nishimura, Nobutaka, additional, Ohnishi, Sayuri, additional, Oda, Yuki, additional, Fujii, Tomomi, additional, Owari, Takuya, additional, Hori, Shunta, additional, Morizawa, Yosuke, additional, Gotoh, Daisuke, additional, Anai, Satoshi, additional, Torimoto, Kazumasa, additional, Tanaka, Nobumichi, additional, Hirao, Yoshihiko, additional, and Fujimoto, Kiyohide, additional

Published
2021
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121. Trends in the Treatment Outcomes and Features of Cryptorchidism in Boys: A Single-Institute Experience

Author

Hori, Shunta, Aoki, Katsuya, Nishimura, Nobutaka, Morizawa, Yosuke, Gotoh, Daisuke, Fukui, Shinji, Nakai, Yasushi, Miyake, Makito, Torimoto, Kazumasa, and Fujimoto, Kiyohide

Subjects
pediatrics, Research and Reports in Urology, spontaneous resolution, hypospadias, orchiopexy, cryptorchidism, Original Research
Abstract

Shunta Hori, Katsuya Aoki, Nobutaka Nishimura, Yosuke Morizawa, Daisuke Gotoh, Shinji Fukui, Yasushi Nakai, Makito Miyake, Kazumasa Torimoto, Kiyohide Fujimoto Department of Urology, Nara Medical University, Kashihara, Nara 634-8522, JapanCorrespondence: Kiyohide FujimotoDepartment of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanTel +81-744-22-3051Fax +81-744-22-9282Email kiyokun@naramed-u.ac.jpPurpose: Cryptorchidism is one of the most common congenital abnormalities in pediatric urology, and orchiopexy is performed for the prevention of testicular damage and malignant transformation. We examined the distribution and outcomes of cryptorchidism under a single investigator at our institute.Patients and Methods: This retrospective study included 283 boys diagnosed with cryptorchidism at our institute. Cryptorchidism was diagnosed based on the medical history and physical examination findings. Boys without spontaneous resolution after 6 months of age were indicated for orchiopexy. We investigated the 12-year trend in the distribution and outcomes of cryptorchidism at the institute.Results: The mean age at diagnosis, gestational age, and birth weight were 2 years, 37 weeks, and 2740 g, respectively. A total of 170 boys underwent orchiopexy under 2 years of age, and 136 boys underwent orchiopexy under the age of 1 year, while 62 boys underwent orchiopexy over the age of 3 years. Abnormalities of the epididymis and disclosure of the processus vaginalis were observed in 44 (25%) and 72 boys (41%), respectively. Comparison of boys with or without hypospadias showed that the age at orchiopexy was higher in boys with hypospadias than in those without hypospadias (P=0.028). In addition, boys without hypospadias had a higher rate of abnormality of the epidermis than those with hypospadias (P=0.024).Conclusion: Our findings suggest that most boys with cryptorchidism are treated under the age of 2 years and the incidence of epididymal abnormality is relatively high, especially in boys with hypospadias. An understanding of the natural features of cryptorchidism could lead to better management and outcomes. Further research is warranted to develop an appropriate treatment timeline in boys with cryptorchidism.Keywords: cryptorchidism, hypospadias, orchiopexy, pediatrics, spontaneous resolution

Published
2020

122. ラット膀胱での水吸収におけるアクアポリン-2の役割

Author

Morizawa, Yosuke, Torimoto, Kazumasa, Hori, Shunta, Gotoh, Daisuke, Nakai, Yasushi, Miyake, Makito, Hirayama, Akihide, Tanaka, Nobumichi, and Fujimoto, Kiyohide

Subjects
aquaporin, desmopressin, water transportion, intravesical fluid volume, bladder
Abstract

AIM: We investigated the role of the bladder wall in permeating water, focusing on aquaporins. METHODS: Female Sprague-Dawley rats weighing 300 g were used to investigate the role of the bladder wall in saline permeation. Changes in intravesical fluid volume and sodium concentration were measured in the desmopressin acetate hydrate-loaded and control groups 3 h after administration. Bladders were resected to measure aquaporin-1, 2, and 3 gene expression using qRT-PCR. Additionally, the change of aquaporin-2 expression was measured using Western blotting and immunohistochemistry in intravesical aquaporin-2 siRNA-treated and control groups. RESULTS: Although the intravesical fluid volume and sodium concentration significantly decreased from 0 to 3 h (1.00 ± 0.00 vs 0.83 ± 0.08 mL, 157.80 ± 1.30 vs 146.8 ± 1.92 mEq/mL, P, 博士（医学）・甲第697号・平成31年3月15日, © 2018 Wiley Periodicals, Inc., This is the pre-peer reviewed version of the following article: [https://onlinelibrary.wiley.com/doi/full/10.1002/nau.23715], which has been published in final form at [http://dx.doi.org/10.1002/nau.23715]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Published
2018

123. Clinical outcomes after intravesical bacillus Calmette–Guérin for the highest‐risk non‐muscle‐invasive bladder cancer newly defined in the Japanese Urological Association Guidelines 2019

Author

Miyamoto, Tatsuki, primary, Miyake, Makito, additional, Toyoshima, Yuta, additional, Fujii, Tomomi, additional, Shimada, Keiji, additional, Nishimura, Nobutaka, additional, Iida, Kota, additional, Nakahama, Tomonori, additional, Hori, Shunta, additional, Gotoh, Daisuke, additional, Nakai, Yasushi, additional, Torimoto, Kazumasa, additional, Tanaka, Nobumichi, additional, Ohbayashi, Chiho, additional, and Fujimoto, Kiyohide, additional

Published
2021
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124. Photodynamic Diagnosis-Assisted En Bloc Transurethral Resection of Bladder Tumor for Nonmuscle Invasive Bladder Cancer: Short-Term Oncologic and Functional Outcomes

Author

Miyake, Makito, primary, Nishimura, Nobutaka, additional, Fujii, Tomomi, additional, Miyamoto, Tatsuki, additional, Iida, Kota, additional, Hori, Shunta, additional, Morizawa, Yosuke, additional, Gotoh, Daisuke, additional, Nakai, Yasushi, additional, Anai, Satoshi, additional, Torimoto, Kazumasa, additional, Tanaka, Nobumichi, additional, and Fujimoto, Kiyohide, additional

Published
2021
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127. Photodynamic Diagnosis-Assisted Transurethral Resection Using Oral 5-Aminolevulinic Acid Decreases the Risk of Repeated Recurrence in Non-Muscle-Invasive Bladder Cancer: A Cumulative Incidence Analysis by the Person-Time Method

Author

Miyake, Makito, primary, Nishimura, Nobutaka, additional, Nakai, Yasushi, additional, Fujii, Tomomi, additional, Owari, Takuya, additional, Hori, Shunta, additional, Morizawa, Yosuke, additional, Gotoh, Daisuke, additional, Anai, Satoshi, additional, Torimoto, Kazumasa, additional, Tanaka, Nobumichi, additional, Hirao, Yoshihiko, additional, and Fujimoto, Kiyohide, additional

Published
2021
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129. Inhibitory Effect of Orally Administered 5-Aminolevulinic Acid on Prostate Carcinogenesis in the FVB-Transgenic Adenocarcinoma of a Mouse Prostate (FVB-TRAMP) Model

Author

Onishi, Kenta, primary, Miyake, Makito, additional, Tatsumi, Yoshihiro, additional, Hori, Shunta, additional, Nakai, Yasushi, additional, Onishi, Sayuri, additional, Iemura, Yusuke, additional, Owari, Takuya, additional, Itami, Yoshitaka, additional, Iida, Kota, additional, Anai, Satoshi, additional, Tanaka, Nobumichi, additional, Shimada, Keiji, additional, and Fujimoto, Kiyohide, additional

Published
2020
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132. Periprostatic fat thickness quantified by preoperative magnetic resonance imaging is an independent risk factor for upstaging from cT1/2 to pT3 in robot‐assisted radical prostatectomy

Author

Iemura, Yusuke, primary, Hori, Shunta, additional, Tatsumi, Yoshihiro, additional, Fukui, Shinji, additional, Miyake, Makito, additional, Matsumura, Yoshiaki, additional, Kagebayashi, Yoriaki, additional, Samma, Shoji, additional, and Fujimoto, Kiyohide, additional

Published
2020
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133. Integrative assessment of clinicopathological parameters and the expression of PD‑L1, PD‑L2 and PD‑1 in tumor cells of retroperitoneal sarcoma

Author

Miyake, Makito, primary, Oda, Yuki, additional, Nishimura, Nobutaka, additional, Morizawa, Yosuke, additional, Ohnishi, Sayuri , additional, Hatakeyama, Kinta , additional, Fujii, Tomomi, additional, Hori, Shunta, additional, Gotoh, Daisuke , additional, Nakai, Yasushi, additional, Anai, Satoshi , additional, Torimoto, Kazumasa, additional, Tsukamoto, Shinji , additional, Fujii, Hiromasa, additional, Kido, Akira, additional, Honoki, Kanya , additional, Matsumura, Yoshiaki , additional, Okajima, Eijiro, additional, Tanaka, Nobumichi, additional, and Fujimoto, Kiyohide, additional

Published
2020
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134. Effects of a new β3‐adrenoceptor agonist, vibegron, on neurogenic bladder dysfunction and remodeling in mice with spinal cord injury

Author

Gotoh, Daisuke, primary, Shimizu, Nobutaka, additional, Wada, Naoki, additional, Kadekawa, Katsumi, additional, Saito, Tetsuichi, additional, Mizoguchi, Shinsuke, additional, Morizawa, Yosuke, additional, Hori, Shunta, additional, Miyake, Makito, additional, Torimoto, Kazumasa, additional, de Groat, William C., additional, Fujimoto, Kiyohide, additional, and Yoshimura, Naoki, additional

Published
2020
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135. Trends in treatment outcomes of hydrocele in Japanese children: A single‐institute experience

Author

Hori, Shunta, primary, Aoki, Katsuya, additional, Ichikawa, Kazuki, additional, Morizawa, Yosuke, additional, Gotoh, Daisuke, additional, Fukui, Shinji, additional, Nakai, Yasushi, additional, Miyake, Makito, additional, Anai, Satoshi, additional, Torimoto, Kazumasa, additional, Tanaka, Nobumichi, additional, Yoneda, Tatsuo, additional, and Fujimoto, Kiyohide, additional

Published
2020
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137. Supplementary Oral Anamorelin Mitigates Anorexia and Skeletal Muscle Atrophy Induced by Gemcitabine Plus Cisplatin Systemic Chemotherapy in a Mouse Model

Author

Miyake, Makito, primary, Hori, Shunta, additional, Itami, Yoshitaka, additional, Oda, Yuki, additional, Owari, Takuya, additional, Fujii, Tomomi, additional, Ohnishi, Sayuri, additional, Morizawa, Yosuke, additional, Gotoh, Daisuke, additional, Nakai, Yasushi, additional, Anai, Satoshi, additional, Torimoto, Kazumasa, additional, Tanaka, Nobumichi, additional, and Fujimoto, Kiyohide, additional

Published
2020
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138. Biochemical control of the combination of cyclooxygenase‐2 inhibitor and 125 I‐brachytherapy for prostate cancer: Post hoc analysis of an open‐label controlled randomized trial

Author

Nakai, Yasushi, primary, Tanaka, Nobumichi, additional, Asakawa, Isao, additional, Anai, Satoshi, additional, Miyake, Makito, additional, Morizawa, Yosuke, additional, Hori, Shunta, additional, Owari, Takuya, additional, Fujii, Tomomi, additional, Ohbayashi, Chiho, additional, Yamaki, Kaori, additional, Hasegawa, Masatoshi, additional, and Fujimoto, Kiyohide, additional

Published
2020
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139. Inhibition of Heparanase Expression Results in Suppression of Invasion, Migration and Adhesion Abilities of Bladder Cancer Cells

Author

Tatsumi, Yoshihiro, primary, Miyake, Makito, additional, Shimada, Keiji, additional, Fujii, Tomomi, additional, Hori, Shunta, additional, Morizawa, Yosuke, additional, Nakai, Yasushi, additional, Anai, Satoshi, additional, Tanaka, Nobumichi, additional, Konishi, Noboru, additional, and Fujimoto, Kiyohide, additional

Published
2020
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140. Initial experience of complete laparoscopic radical nephroureterectomy combined with transvesical laparoscopic excision of distal ureter in patients with upper urinary tract cancer

Author

Miyake, Makito, primary, Nishimura, Nobutaka, additional, Aoki, Katsuya, additional, Ohmori, Chihiro, additional, Shimizu, Takuto, additional, Owari, Takuya, additional, Hori, Shunta, additional, Morizawa, Yosuke, additional, Gotoh, Daisuke, additional, Nakai, Yasushi, additional, Anai, Satoshi, additional, Torimoto, Kazumasa, additional, Tanaka, Nobumich, additional, and Fujimoto, Kiyohide, additional

Published
2020
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141. Clinical Impact of Sarcopenia and Inflammatory/Nutritional Markers in Patients with Unresectable Metastatic Urothelial Carcinoma Treated with Pembrolizumab

Author

Shimizu, Takuto, primary, Miyake, Makito, additional, Hori, Shunta, additional, Ichikawa, Kazuki, additional, Omori, Chihiro, additional, Iemura, Yusuke, additional, Owari, Takuya, additional, Itami, Yoshitaka, additional, Nakai, Yasushi, additional, Anai, Satoshi, additional, Tomioka, Atsushi, additional, Tanaka, Nobumichi, additional, and Fujimoto, Kiyohide, additional

Published
2020
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142. Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma

Author

Shimizu, Takuto, primary, Miyake, Makito, additional, Hori, Shunta, additional, Iida, Kota, additional, Ichikawa, Kazuki, additional, Sakamoto, Keiichi, additional, Miyamoto, Tatsuki, additional, Nakai, Yasushi, additional, Inoue, Takeshi, additional, Anai, Satoshi, additional, Tanaka, Nobumichi, additional, and Fujimoto, Kiyohide, additional

Published
2020
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144. Disabled Homolog 2 (DAB2) Protein in Tumor Microenvironment Correlates with Aggressive Phenotype in Human Urothelial Carcinoma of the Bladder

Author

Itami, Yoshitaka, primary, Miyake, Makito, additional, Ohnishi, Sayuri, additional, Tatsumi, Yoshihiro, additional, Gotoh, Daisuke, additional, Hori, Shunta, additional, Morizawa, Yousuke, additional, Iida, Kota, additional, Ohnishi, Kenta, additional, Nakai, Yasushi, additional, Inoue, Takeshi, additional, Anai, Satoshi, additional, Tanaka, Nobumichi, additional, Fujii, Tomomi, additional, Shimada, Keiji, additional, Furuya, Hideki, additional, Khadka, Vedbar S., additional, Deng, Youping, additional, and Fujimoto, Kiyohide, additional

Published
2020
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145. PDE5阻害薬であるタダラフィルは糖尿病ラットの膀胱血流を改善し、初期段階に低下する下部尿路機能を回復する

Author

Gotoh, Daisuke, Torimoto, Kazumasa, Tatsumi, Yoshihiro, Hori, Shunta, Yamada, Atsushi, Miyake, Makito, Morizawa, Yosuke, Aoki, Katsuya, Tanaka, Nobumichi, Hirayama, Akihide, and Fujimoto, Kiyohide

Subjects
rat, ischemia, phosphodiesterase 5, bladder
Abstract

AIMS: To investigate the effect of tadalafil on bladder blood flow and lower urinary tract function in a rat model of diabetes. MATERIALS AND METHODS: We studied female Sprague-Dawley rats and induced diabetes in some using a single intraperitoneal injection of streptozotocin. We divided the rats into nondiabetes (ND), diabetes (D), and diabetes with tadalafil (DT) groups. The rats were raised for an additional 7 weeks after diabetes induction. The DT group received oral tadalafil (2 mg/kg/day) for 7 days before the experiments. At 7 weeks after diabetes induction, we performed cystometry, resected the bladders for immunohistochemistry (hypoxia-inducible factor-1α [HIF-1α] and 8-oxo-2'-deoxyguanosine [8-OHdG] staining), and measured bladder blood supply using a laser blood flow meter. RESULTS: The opening pressure, when the urethra opens and urine flow starts, was significantly lower in the DT group than in the D group (24.9 ± 5.9 vs 43.6 ± 12.3 cmH2 O). The inter-contraction interval was significantly longer in the D group than in the ND and DT groups (1566.2 ± 168.7 vs 702.9 ± 165.2 and 787.4 ± 148.8 s). Immunohistochemistry showed positive staining of the urothelial layer for both HIF-1α and 8-OHdG in the D group, but not in the ND or DT groups. Bladder blood flow was significantly lower in the D group than in the ND or DT groups. CONCLUSIONS: Tadalafil improves bladder blood supply and lower urinary tract function in diabetic rats. Tadalafil may be a promising drug that restores lower urinary tract dysfunction in the early phase of diabetes., 博士（医学）・甲第677号・平成30年3月15日, © 2017 Wiley Periodicals, Inc., This is the peer reviewed version of the following article : which has been published in final form at http://dx.doi.org/10.1002/nau.23372. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Published
2017

146. The effects of choreito on a model of nocturnal polyuria using Dahl salt‐sensitive rats.

Author

Iwamoto, Takashi, Torimoto, Kazumasa, Gotoh, Daisuke, Hori, Shunta, Nakai, Yasushi, Miyake, Makito, Tokita, Yohei, Kobayashi, Ryohei, Aoki, Katsuya, and Fujimoto, Kiyohide

Subjects
NOCTURIA, HIGH-salt diet, SYSTOLIC blood pressure, WATER restrictions, DRINKING (Physiology)
Abstract

Objectives: This study aimed to determine whether Dahl salt‐sensitive rats fed a high‐salt diet would show features of nocturia due to nocturnal polyuria and to examine the efficacy of choreito (CRT) on nocturnal polyuria. Methods: Dahl salt‐sensitive rats were divided into three groups. Group A was fed a 4% salt diet, group B a 2% salt diet, and group C a normal 0.3% salt diet. In groups α and β, other rats were further divided into two groups: The rats in group α were fed a 2% salt plus 3% CRT diet, and those in group β, were fed a 2% salt diet. Each rat was placed in an individual metabolic cage for 24 hours every week for 6 weeks. Water intake, urine production, voiding frequency, and voided volume per micturition were recorded. Results: The systolic blood pressure increased in the group fed a 4% salt diet compared to groups fed with a 2% and 0.3% salt diet. The urinary volume was higher in the groups fed with 4% and 2% salt than in the group fed with 0.3% salt. Further, water intake in the group fed a 2% salt plus 3% CRT diet was significantly lower than that in the group fed with a 2% salt diet. Conclusions: Dahl salt‐sensitive rats fed a 2% salt diet were candidates for a model of nocturnal polyuria. Using this model, we suggest that CRT reduces water intake in the active phase and contributes to water restriction in the treatment of nocturnal polyuria. [ABSTRACT FROM AUTHOR]

Published
2022
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147. Usefulness of clinical factors for diagnosing and differentiating types of testicular malposition in boys: A retrospective study.

Author

Hori, Shunta, Aoki, Katsuya, Tachibana, Akira, Nishimura, Nobutaka, Tomizawa, Mitsuru, Morizawa, Yosuke, Gotoh, Daisuke, Fukui, Shinji, Nakai, Yasushi, Miyake, Makito, Torimoto, Kazumasa, Yoneda, Tatsuo, Tanaka, Nobumichi, and Fujimoto, Kiyohide

Subjects
*CRYPTORCHISM, *TESTIS, *DIAGNOSIS, *RETROSPECTIVE studies, *ORCHIOPEXY, *MULTIVARIATE analysis
Abstract

Objective: To investigate useful objective variables and factors supporting the diagnosis of retractile testis and cryptorchidism by primary care providers, including urologists. Methods: This retrospective study included 512 boys diagnosed with retractile testis or cryptorchidism at our institute. Boys with retractile testis were followed up and underwent orchiopexy once the testis became undescended, while boys with cryptorchidism underwent orchiopexy immediately. We investigated trends in the prevalence of testicular malposition and explored useful diagnostic factors for retractile testis and cryptorchidism. Results: Of 512 boys, 199 were diagnosed with retractile testis and 313 were diagnosed with cryptorchidism. Comparison of clinical information between retractile testis and cryptorchidism showed that age at diagnosis, laterality, and location of the testis were significantly different between the groups (P < 0.0001, P < 0.0001, and P < 0.0001, respectively). The comparison of surgical information also showed that epididymal abnormality and state of processus vaginalis is patency or closure were significantly different between the groups (P = 0.0088 and P = 0.0003, respectively). Multivariate analysis showed that diagnosis at age 0–1 years, unilaterality, and canalicular testis were predictive factors for cryptorchidism (P = 0.001, P < 0.0001, and P < 0.0001, respectively). Conclusions: Age at diagnosis, laterality, and location of the testis could be factors to aid the diagnosis of retractile testis and cryptorchidism. [ABSTRACT FROM AUTHOR]

Published
2022
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148. Assessment of bladder function for stabilizing urinary volume overnight with recording of brain waves (ABSORB study).

Author

Torimoto, Kazumasa, Matsushita, Chie, Itami, Yoshitaka, Iwamoto, Takashi, Owari, Takuya, Gotoh, Daisuke, Miyake, Makito, Hori, Shunta, Nakai, Yasushi, Aoki, Katsuya, Hirao, Shuya, Momose, Hitoshi, Tanaka, Nobumichi, and Fujimoto, Kiyohide

Subjects
BRAIN waves, FUNCTIONAL assessment, SLEEP-wake cycle, URINARY organs, URINARY catheters, INTRAVESICAL administration, CYSTOMETRY
Abstract

Objectives: The bladder urothelium is not always impermeable. During sleep, the bladder might absorb urine in healthy individuals who sleep through the night. This study aimed to determine whether the bladder absorbs urine by using a method other than ultrasonic scanning and to simultaneously evaluate sleeping conditions. Methods: Eleven participants (five males, six females) aged 20 to 49 years without lower urinary tract symptoms or urination while sleeping were enrolled. Bladder volume was estimated by studying the relationship between dilution and absorbance of indigo carmine dissolved in urine. A 12F Foley catheter was inserted into the bladder before sleep. Urine samples (5 mL) were extracted at 2, 3, 4, 5, and 6 am sleep stages were monitored with a single‐channel portable electroencephalograph device. Results: The estimated bladder volume at 6 am and voided volume immediately after rising were significantly correlated (Spearman's ρ = 0.62, P =.046). Eight participants (three males, five females) showed an absorption pattern of the estimated bladder volume change. In a male participant, the blue dye's strength gradually decreased until 4 am (estimated 859 mL) and increased from 5 am (estimated 455 mL). In another, the blue dye's strength increased at 4 am (estimated 449 mL) vs at 3 am (estimated 757 mL). In all participants, electroencephalograph data demonstrated that sleep was maintained despite having a full bladder. Conclusions: The bladder absorbs urine and maintains an approximate volume of functional bladder capacity during sleep to avoid incontinence and maintain sleep in adults due to an urge to void urine during the sleep cycle. [ABSTRACT FROM AUTHOR]

Published
2022
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149. Factors affecting urinary frequency after low‐dose‐rate brachytherapy for prostate cancer.

Author

Uematsu, Toshitaka, Torimoto, Kazumasa, Tanaka, Nobumichi, Asakawa, Isao, Hori, Shunta, Yamaki, Kaori, Nakai, Yasushi, Miyake, Makito, Anai, Satoshi, Hasegawa, Masatoshi, and Fujimoto, Kiyohide

Subjects
PROSTATE cancer, RADIOISOTOPE brachytherapy, URINARY organs, MULTIPLE regression analysis, EXTERNAL beam radiotherapy
Abstract

Objectives: Lower urinary tract symptoms are transiently exacerbated by low‐dose‐rate brachytherapy (LDR‐BT) for prostate cancer and recover to pretreatment levels 1 year thereafter. Generally, these symptoms are influenced by temperature. We aimed to search for factors affecting the lower urinary tract symptoms after seed implant including seasons. Methods: We retrospectively enrolled 812 patients who underwent LDR‐BT at Nara Medical University Hospital from January 2010 to December 2018 and for whom the International Prostate Symptom Score, Overactive Bladder Symptom Score, and frequency volume charts were available. We investigated the relationships between lower urinary tract symptoms, 24‐hours urinary frequency, 24‐hours urinary volume before and after seed implant, radiation dose, and season of seed implant. Results: The mean age was 69.5 years. The mean prostate volume was 24.2 mL. The International Prostate Symptom Score, Overactive Bladder Symptom Score, and 24‐hours urinary frequency increased until 3 months and gradually decreased over 6 months after seed implant. Multiple linear regression analysis revealed that 24‐hours urinary frequency at 3 months after seed implant was significantly influenced by external beam radiotherapy, larger prostate volume before implant, higher 24‐hours urinary frequency at baseline, larger 24‐hours urinary volume at 3 months after implant, and performance of implant in summer. Conclusions: Lower urinary tract symptoms worsened 3 months after seed implant of LDR‐BT regardless of the season of implant. The urinary frequency 3 months after seed implant was slightly lower when seed implant was performed in the summer. [ABSTRACT FROM AUTHOR]

Published
2022
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150. Video‐urodynamic effects of vibegron, a new selective β3‐adrenoceptor agonist, on antimuscarinic‐resistant neurogenic bladder dysfunction in patients with spina bifida.

Author

Aoki, Katsuya, Momose, Hitoshi, Gotoh, Daisuke, Morizawa, Yosuke, Hori, Shunta, Nakai, Yasushi, Miyake, Makito, Anai, Satoshi, Torimoto, Kazumasa, Tanaka, Nobumichi, Yoneda, Tatsuo, Matsumoto, Yoshihiro, and Fujimoto, Kiyohide

Subjects
NEUROGENIC bladder, SPINA bifida, BLADDER diseases, CYSTOMETRY, VESICO-ureteral reflux, MUSCARINIC antagonists
Abstract

Objectives: To evaluate the efficacy, safety and tolerability of vibegron for the treatment of antimuscarinic‐resistant neurogenic bladder dysfunction in patients with spina bifida. Methods: In this retrospective study, 15 patients with antimuscarinic‐resistant neurogenic bladder dysfunction due to spina bifida underwent a video‐urodynamic study before and during the administration of vibegron 50 mg once daily instead of antimuscarinic agents from February 2019 through April 2021. The video‐urodynamic study was carried out to evaluate bladder compliance, maximum cystometric bladder capacity, detrusor overactivity, detrusor leak point pressure and vesicoureteral reflux before and >3 months after the beginning of vibegron administration. Results: Treatment with vibegron significantly improved bladder compliance and maximum cystometric bladder capacity compared with antimuscarinic agents, respectively (7.4 ± 4.2 vs 30.4 ± 48.2 mL/cmH2O, P = 0.0001; 231.4 ± 81.2 vs 325.2 ± 106.5 mL, P = 0.0005). Detrusor overactivity did not change after the administration of vibegron. Bladder deformity, which was confirmed in 12 patients, improved in half of the patients after taking vibegron. Vesicoureteral reflux, which was confirmed in two patients, was extinguished after taking vibegron. Newly occurring adverse events were not observed, and all patients continued to take vibegron during the treatment period. Conclusions: Favorable efficacy of vibegron for antimuscarinic‐resistant neurogenic bladder dysfunction due to spina bifida was shown video‐urodynamically without apparent adverse events. Vibegron is a favorable option for the treatment of antimuscarinic‐resistant neurogenic bladder dysfunction in patients with spina bifida. [ABSTRACT FROM AUTHOR]

Published
2022
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