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A new creative design approach is put forward based on variable length gene expression and intuition models. The number of product requirements, the gene length expressing requirements, the structure of the product, and the correlation matrix are varied with individuation of customer requirements of the product. By research on the calculation mechanisms of dynamic variety, the approaches of variable length gene expression are proposed. The intuition process reflects that the thinking of human brain produces qualitative change. An approach of intuition simulation is used by Hebb learning law, Hopfield neural networks and crossover and mutation. The calculating models and the calculating formulas for the creative design are put forward. Finally, An example for the creative design of a solar energy portable lamp is given. The better results are obtained in the creative design.

This paper introduces functions and features of the MPEG-4 streaming media, combine its media properties with Microsoft's digital rights management component WMRM, design and implemented the digital rights management system based on MPEG-4 streaming media, this system possessed a higher Security and stability, it has a high application value on development of streaming media in e-commerce.

Traffic Grooming in optical networks is one if the most important and hot problems in the area of optical network. In the static traffic grooming problem, we introduce the concept of QoS (Quality of Service); in order to minimize the network cost utilization rate and to maximize the QoS degree of the users at the same time, we apply the intelligent computing algorithm -QIA( the quantum-based Immune Algorithm) to the framework to solve the problem.

Background Chemotherapy is an important component in the treatment paradigm for breast cancers. However, the resistance of cancer cells to chemotherapeutic agents frequently results in the subsequent recurrence and metastasis. Identification of molecular markers to predict treatment outcome is therefore warranted. The aim of the present study was to evaluate whether expression of circulating microRNAs (miRNAs) can predict clinical outcome in breast cancer patients treated with adjuvant chemotherapy. Methodology/Principal Findings Circulating miRNAs in blood serum prior to treatment were determined by quantitative Real-Time PCR in 56 breast cancer patients with invasive ductal carcinoma and pre-operative neoadjuvant chemotherapy. Proliferating cell nuclear antigen (PCNA) immunostaining and TUNEL were performed in surgical samples to determine the effects of chemotherapy on cancer cell proliferation and apoptosis, respectively. Among the miRNAs tested, only miR-125b was significantly associated with therapeutic response, exhibiting higher expression level in non-responsive patients (n = 26, 46%; p = 0.008). In addition, breast cancers with high miR-125b expression had higher percentage of proliferating cells and lower percentage of apoptotic cells in the corresponding surgical specimens obtained after neoadjuvant chemotherapy. Increased resistance to anticancer drug was observed in vitro in breast cancer cells with ectopic miR-125b expression; conversely, reducing miR-125b level sensitized breast cancer cells to chemotherapy. Moreover, we demonstrated that the E2F3 was a direct target of miR-125b in breast cancer cells. Conclusions/Significance These data suggest that circulating miR-125b expression is associated with chemotherapeutic resistance of breast cancer. This finding has important implications in the development of targeted therapeutics for overcoming chemotherapeutic resistance in novel anti-cancer strategies.

In the system of the PV grid-connected generation, because of the dispersion of the PV panel, difference of the sun radiation condition and the shadow of a part of the PV panel, they will cause the serious loss of energy for the parallel PV panel. In order to overcoming energy loss and raise the efficiency of the PV system, a new maximum power point tracking method called distributed variable step duty ratio perturb method is put forward. The distributed MPPT method overcomes the shortcomings to generate electricity quantity to descend because of the dispersion of the PV panel. The variable step duty ratio perturbing method speed quickly and is more suitable for this kind of distributed generation system. The hardware adopts DC/DC electric circuit to regulate PWM duty ratio. The software adopts TMS320-2812. An example is given to show that this method is able to realize distributed MPPT. In addition, the calculation speed of the approach is quick, accuracy of the approach is better, and the system has a high stability.

A method for the traffic signal recognition of his color space and bp neural network algorithm. First convert the traffic signal images from RGB space to HSI space, and then extracted H Component characteristics from HSI space in the traffic signal images, according to the Component histogram, determine the signal color. Finally, BP neural network is applied for the traffic signal lights recognition. It's demonstrated by practice that BP neural network can be used for fast and efficient recognition of traffic signal with high accuracy and practical value.

Digital Rights Management (DRM) technology play a very important role in solving the problems of digital copyright, it includes streaming media servers, authentication servers, web servers, file servers, database servers several parts. The paper mainly discusses the design and implementation of authentication server.

To investigate the safety, feasibility and the impact of different extents of lymph node dissection on the survival in the patients with locally advanced thoracic esophageal carcinoma.From January 2001 to December 2006, 122 patients with locally advanced thoracic esophageal carcinoma underwent radical resection through cervical, thoracic, and abdominal incisions, and were randomly divided into two-field lymph node dissection group (Two-FD) and three-field lymph node dissection group (Three-FD). Life-table method was used to compare the difference of survival rates between the two groups. Kaplan-Meier method was used to compare the cumulative survival time and median survival time between the two groups. Multivariate analysis was performed using Cox model to identify the prognostic factors affecting the survival (alpha = 0.05).There was no significant difference between the two groups in age, sex, and disease stage. Postoperative complication rate and perioperative mortality rate were 14.5% and 1.6% in the two-FD group versus 15.0% and 1.7% in the three-FD group, statistically without a significant difference (P0.05). The 1-, 3- and 5-year survival rates were 78.2%, 39.6% and 14.5% in the two-FD group, and 83.7%, 42.4% and 18.1% in the three-FD group, respectively. The median survival time was 24.0 months in the two-FD group and 31.0 months in the three-FD group. Log-rank analysis showed that in the patients without preoperative weight loss, in T3N1M0 stage, only single regional lymph node metastasis but3 in total, the three field lymph node dissection achieved a better prognosis (P0.05). Multivariate analysis using Cox model showed that T and N stages and lymph node dissection extent were still risk factors in patients with stage III locally advanced thoracic esophageal carcinoma.Compared with the two field lymph node dissection, the three field lymph node dissection is safe and feasible, and can improve the survival for a part of stage III esophageal cancer patients without increase in operative mortality and complications.

In the past two decades, the use of the weight decay regularizer for improving the generalization ability of neural networks has been extensively investigated. However, most existing results focus on the fault-free neural networks only. This papers extends the analysis on the generalization ability for networks with multiplicative weight noise. Our analysis result allows us not only to estimate the generalization ability of a faulty network, but also to select a good model from various settings. Simulated experiments are performed to verify theoretical result.

Dexing Copper Deposit, located in Jiangxi province, China, is one of the largest porphyry copper deposits in the world, the copper content of which exceeds eight million tonnes. Fine hundred million tonnes of waste rock with grades between 0.1 and 0.3 will be produced during open pit mining of Dexing. The amount of copper metal is 1.2 million tonnes. In order to extract copper metal from those secondary resources and resolve the environmental problems caused by acidic water and heavy metals released from the waste rock dump, a dump bioleaching-solvent extraction-electrowinning plant was designed based on a series of experimental investigations. Presently, there are a number of challenges faced by this plant, such as low recovery efficiency, low Cu2+ concentration and limited production. The investigation shows that the low- grade of the dump, refractoriness of chalcopyrite, small sprinkling area, leakage of pad, small bacteria population, low dump permeability are the main factors that contribute to the challenges. Several measures were exercised by the plant, such as separating ores from rocks, stripping and loosening the surface layer of dump, loosening the entire dump by use of explosives. Besides those challenges, stability of the high and steep slope of the dump is a hidden danger to which much attention is not paid. The height of the dump exceeds 70 m, and the inclination of the slope is 55°. The failure of dump could result in a dangerous disaster. Mechanical properties of the waste rock before and after leaching were investigated. The result shows that the normal stress, shear strength and cohesion decreased sharply during the leaching process.

Diaphragmatic hernia of the liver is a rare clinical entity, usually found after trauma in adults. This study was undertaken to elucidate a misdiagnosis of non-traumatic diaphragmatic hernia of the liver in an adult.The clinical data of one patient with non-traumatic diaphragmatic hernia of the liver was analyzed.A tumor in the right lower thorax was revealed by chest X-ray and computed tomography. Non-traumatic diaphragmatic hernia of the liver was not identified until the operation. Pathological analysis confirmed the finding. The patient recovered well.Non-traumatic diaphragmatic hernia of the liver in an adult is a rare right-sided diaphragmatic hernia, which can move up into the chest cavity. It should be distinguished from lung cancer. The diagnosis and evaluation of non-traumatic diaphragmatic hernia of the liver can help optimize surgical management.

Hydrophobic bile acids lead to the generation of oxygen free radicals in mitochondria. Accordingly, this study is to investigate if gene delivery of superoxide dismutase (SOD) will reduce hepatocyte injury caused by experimental cholestasis.The recombinant of pLNCX-SOD gene packaged with lipofection of AMINE was transfected into hepatocytes in vitro, which stably expressed the SOD gene.After transfection, hepatocytes enhanced the protective effect against injury to bile and the toxicity of serum in obstructive jaundice. The inhibition of bile at the concentration of 2% (v:v, bile: DMEM 1:50) decreased obviously from (78.80+/-12.35)% to (43.35+/-9.69)% in 12 hours, from (82.55+/-11.27)% to (-26.64+/-7.66)% in 24 hours, and from (83.83+/-18.69)% to (-19.27+/-14.38)% in 48 hours, compared with that of the untransfected cells (P0.01). The inhibition of serum at the obstructive jaudice concentration of 2.5% was obviously decreased from (89.72+/-1.52)% to (14.68+/-14.33)% in 12 hours, from (92.2+/-11.27)% to (41.39+/-7.66)% in 24 hours, and from (94.25+/-8.96)% to (22.71+/-4.38)% in 48 hours (P0.01).Hepatocytes transfected with the pLNCX-SOD gene could obviously be resistant to the toxicity of bile and serum from rat with obstructive jaundice.

We reported a case of malignant nonfunction islet cell tumor (10.0 cm in diameter) of the pancreas, with malignant histological features and splenic infiltration. The case is rare, and few reports have been published.A 46-year-old woman with a vague pain in the left upper quadrant for 3 months was found to have a tumor in the spleen. Ultrasonography and computed tomography demonstrated a well-defined pancreatic tumor of 8.2 X 10.0 cm in size, her serum levels of pancreatic hormones were within normal limits.Splenectomy combined with pancreatectomy was performed for the tail of the pancreas. Resected specimens showed a malignant nonfunctioning islet cell tumor invading the spleen.The growth pattern of the tumor causes malignant features. Resection of the tumor should be performed by enucleation, pancreaticoduodenectomy or distal pancreatectomy.

Extrahepatic portal vein aneurysm is a rare clinical entity with no more than 50 reported cases in the English literature. This study was to elucidate the procedures used in the diagnosis and management of portal vein aneurysm.The clinical data of a patient with extrahepatic portal vein aneurysm were analyzed.Extrahepatic portal vein aneurysm associated with portal hypertension and splenomegaly was diagnosed by color Doppler ultrasonography (US), computed tomography (CT), magnetic resonance angiography (MRA) and angiography (indirect portography). Splenectomy and surgical shunt (splenorenal shunt) were performed. No hepatic encephalopathy and variceal bleeding occurred after the operation except mild pancreatic leakage caused by partial pancreatic tail resection. The patient recovered well.Extrahepatic portal vein aneurysm can be evaluated by US, CT, MRA, and angiography for optimum conservative or surgical management.

To explore the clinical value of laparoscopy and laparoscopic ultrasonography (LUS) in judging the resectability of pancreatic head cancer.LUS was employed as a prospective diagnosis of tumor staging before exploratory laparotomy in 22 patients diagnosed with pancreatic head cancer to identify whether the liver and peritoneum had small metastases or local invasion to the portal vein, superior mesenteric vessel, aorta, inferior vena cava.In the 22 patients receiving laparoscopy and LUS, we found peritoneal or surface liver metastases (3 patients), hepatic parenchyma metastases (1), and pancreatitis proved by biopsy under ultrasound guidance (1). Laparotomy was avoided in these 5 patients. Of the remaining 17 patients, 8 patients, including 2 patients with portal vein emboli due to tumor metastases had hypertrophic lymph nodes or tumor invasion of local vessels in the peritoneal cavity, retroperitoneum, and omentum and the other 9 patients had resectable tumors shown by LUS. The 17 patients were subjected to exploratory laparotomy, and pancreaticoduodenectomy was successful in 8 patients.Laparoscopy and LUS can be used to precisely estimate the possibility of resection of pancreatic head cancer, and prevent unnecessary exploratory laparotomy and its complications. It can be used as a routine examination before exploratory laparotomy.