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107. Contributors

Author

Abernethy, Robert S., primary, Abrams, Annah N., additional, Alonso, Anne, additional, Alpay, Menekse, additional, Alpert, Jonathan E., additional, Baer, Lee, additional, Baity, Matthew R., additional, Barry, Colleen L., additional, Beck, BJ, additional, Becker, Anne E., additional, Benedek, David M., additional, Beresin, Eugene V., additional, Biederman, Joseph, additional, Blacker, Deborah, additional, Blais, Mark A., additional, Bostic, Jeff Q., additional, Braun, Ilana Monica, additional, Brendel, Rebecca W., additional, Brennan, Megan Moore, additional, Bush, George, additional, Caplan, Jason P., additional, Carter, Christopher G., additional, Cassano, Paolo, additional, Cassem, Ned H., additional, Cohen, Lee S., additional, Coyle, Joseph T., additional, Cremens, M. Cornelia, additional, Danforth, Nicole, additional, Delong, Hannah, additional, Derenne, Jennifer L., additional, Dickerson, Bradford C., additional, Donovan, Abigail L., additional, Dougherty, Darin D., additional, Edersheim, Judith G., additional, Epstein, Lucy A., additional, Eyler, A. Evan, additional, Falk, William E., additional, Fan, Xiaoduo, additional, Fava, Maurizio, additional, Finn, Christine T., additional, Fishel, Anne K., additional, Flaherty, Alice W., additional, Freudenreich, Oliver, additional, Fricchione, Gregory L., additional, Gardner-Schuster, Erica E., additional, Georgiopoulos, Anna M., additional, Gilbertson, Mark W., additional, Goff, Donald C., additional, Gordon, Christopher, additional, Gould, Cathleen M., additional, Grant, Marni, additional, Greenberg, Donna B., additional, Greer, David M., additional, Gross, Anne F., additional, Groves, James E., additional, Hazen, Eric P., additional, Henderson, David C., additional, Herman, John B., additional, Hirdes, John P., additional, Holt, Daphne J., additional, Hovelson, Daniel H., additional, Huffman, Jeff C., additional, Jenike, Michael A., additional, Julian, John N., additional, Kam, Raymond W., additional, Kelly, John F., additional, Keuthen, Nancy J., additional, Khoshbin, Shahram, additional, Kinrys, Gustavo, additional, Klibanski, Anne, additional, Kontos, Nicholas, additional, Kutner, Lawrence, additional, Lagomasino, Isabel T., additional, LeBeau, Richard T., additional, Lee, Jong Woo, additional, Leveroni, Catherine, additional, McKeon, Jeanne, additional, Messner, Edward, additional, Mickley, Diane W., additional, Milosavljevic, Nada, additional, Mischoulon, David, additional, Mollica, Richard F., additional, Morrow, Eric M., additional, Muriel, Anna C., additional, Murray, Evan D., additional, Murray, George B., additional, Nicolson, Stephen E., additional, Nierenberg, Andrew A., additional, Nonacs, Ruta M., additional, O'Keefe, Sheila M., additional, Olatunji, Bunmi O., additional, Olson, Cheryl K., additional, Öngür, Dost, additional, Orr, Scott P., additional, Ostacher, Michael J., additional, Otto, Michael W., additional, Papakostas, George I., additional, Park, Jennifer M., additional, Park, Lawrence, additional, Perlis, Roy H., additional, Pirl, William F., additional, Pitman, Roger K., additional, Pollack, Mark H., additional, Pollak, Lauren Norton, additional, Powell, Alicia D., additional, Prager, Laura M., additional, Price, Bruce Heimburger, additional, Prince, Jefferson B., additional, Querques, John, additional, Rabinowitz, Terry, additional, Rauch, Scott L., additional, Reese, Hannah E., additional, Renner, John A., additional, Ritchie, Elspeth Cameron, additional, Rivas-Vazquez, Rafael A., additional, Rizzoli, Paul B., additional, Roffman, Joshua L., additional, Rosenbaum, Jerrold F., additional, Rosenquist, J. Niels, additional, Roth, Thomas, additional, Rubin, David Harris, additional, Rundell, James R., additional, Sanders, Kathy M., additional, Schlozman, Steven C., additional, Schouten, Ronald, additional, Shafer, Linda C., additional, Sherman, Janet Cohen, additional, Simon, Naomi M., additional, Smallwood, Patrick, additional, Smith, Felicia A., additional, Smoller, Jordan W., additional, Spencer, Thomas J., additional, Stakes, John W., additional, Stern, Theodore A., additional, Stewart, S. Evelyn, additional, Stewart, Samantha Andrien, additional, Stewart, Thomas D., additional, Surman, Owen S., additional, Taylor, Charles T., additional, Tilley, Claire A., additional, Trinh, Nhi-Ha, additional, Vasconcelos e Sá, Débora, additional, Viguera, Adele C., additional, Wang, Betty C., additional, Ward, E. Nalan, additional, Wasan, Ajay D., additional, Weilburg, Jeffrey B., additional, Weisman, Avery D., additional, Weiss, Anthony P., additional, Welch, Charles A., additional, Wilbur, Julie E., additional, Wilens, Timothy E., additional, Wilhelm, Sabine, additional, Wolf, Daniel H., additional, Wright, Christopher I., additional, and Yeung, Albert, additional

Published
2008
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111. Effect of Citalopram on Hippocampal Atrophy in First-Episode Psychosis: Structural MRI Results From the DECIFER Trial

Author

Qi, Wei, primary, Li, Chenxiang, additional, Blessing, Esther, additional, Ardekani, Babak, additional, Freudenreich, Oliver, additional, Cather, Corinne, additional, Holt, Daphne, additional, Bello, Iruma, additional, Diminich, Erica, additional, Tang, Yingying, additional, Worthington, Michelle, additional, Zeng, Botao, additional, Wu, Renrong, additional, Fan, Xiaoduo, additional, Wang, Jijun, additional, Zhao, Jingping, additional, Troxel, Andrea, additional, and Goff, Donald C., additional

Published
2020
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128. The Global Meningococcal Initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection

Author

Borrow, Ray, Alarcón, Pedro, Carlos, Josefina, Caugant, Dominique A, Christensen, Hannah, Debbag, Roberto, De Wals, Philippe, Echániz-Aviles, Gabriela, Findlow, Jamie, Head, Chris, Holt, Daphne, Kamiya, Hajime, Saha, Samir K, Sidorenko, Sergey, Taha, Muhamed-Kheir, Trotter, Caroline, Vázquez Moreno, Julio A, Von Gottberg, Anne, Sáfadi, Marco AP, Global Meningococcal Initiative, Trotter, Caroline [0000-0003-4000-2708], and Apollo - University of Cambridge Repository

Subjects
meningococcal disease, Vaccines, Conjugate, Global Meningococcal Initiative, Epidemiology, Immunization Programs, Incidence, Meningococcal Vaccines, Neisseria meningitidis, Meningitis, Meningococcal, vaccination, Global Health, Disease Outbreaks, Meningococcal Infections, prevention, outbreaks, surveillance, Humans, MenW, serogroups
Abstract

The 2015 Global Meningococcal Initiative (GMI) meeting discussed the global importance of meningococcal disease (MD) and its continually changing epidemiology. Areas covered: Although recent vaccination programs have been successful in reducing incidence in many countries (e.g. Neisseria meningitidis serogroup [Men]C in Brazil, MenA in the African meningitis belt), new clones have emerged, causing outbreaks (e.g. MenW in South America, MenC in Nigeria and Niger). The importance of herd protection was highlighted, emphasizing the need for high vaccination uptake among those with the highest carriage rates, as was the need for boosters to maintain individual and herd protection following decline of immune response after primary immunization. Expert commentary: The GMI Global Recommendations for Meningococcal Disease were updated to include a recommendation to enable access to whole-genome sequencing as for surveillance, guidance on strain typing to guide use of subcapsular vaccines, and recognition of the importance of advocacy and awareness campaigns.

Published
2017

129. Are Negative Symptoms Merely the "Real World" Consequences of Deficits in Social Cognition?

Author

Pelletier-Baldelli, Andrea and Holt, Daphne J

Subjects
COGNITION disorders diagnosis, BRAIN, LIFE skills, SCHIZOPHRENIA, SOCIAL skills
Abstract

Many investigations have demonstrated that negative symptoms and social cognitive deficits in schizophrenia play a large role in determining functional outcomes and ultimately long-term prognosis. Given this, there is increasing interest in understanding the relationship between these two symptom domains, particularly since studies have consistently found moderate to large associations between them. This shared variance raises a key question: to what degree do these two categories of symptoms arise from overlapping or identical changes in brain function? In other words, do some or all negative symptoms represent merely the downstream effects of social cognition deficits on daily functioning? In this commentary, the evidence for and against this possibility, limitations of currently validated empirical measurements of these symptoms, and directions for further investigation of this hypothesis are discussed. Understanding the shared and distinct mechanisms of these disabling deficits will have important implications for the design of novel, personalized treatments for psychotic illness. [ABSTRACT FROM AUTHOR]

Published
2020
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130. Increased amygdala-visual cortex connectivity in youth with persecutory ideation.

Author

DeCross, Stephanie N., Farabaugh, Amy H., Holmes, Avram J., Ward, Maeve, Boeke, Emily A., Wolthusen, Rick P. F., Coombs III, Garth, Nyer, Maren, Fava, Maurizio, Buckner, Randy L., and Holt, Daphne J.

Subjects
AMYGDALOID body, DELUSIONS, FEAR, MAGNETIC resonance imaging, OCCIPITAL lobe, PARANOIA, PSYCHOSES, PSYCHOLOGICAL stress, NEURAL pathways
Abstract

Background: Subclinical delusional ideas, including persecutory beliefs, in otherwise healthy individuals are heritable symptoms associated with increased risk for psychotic illness, possibly representing an expression of one end of a continuum of psychosis severity. The identification of variation in brain function associated with these symptoms may provide insights about the neurobiology of delusions in clinical psychosis. Methods: A resting-state functional magnetic resonance imaging scan was collected from 131 young adults with a wide range of severity of subclinical delusional beliefs, including persecutory ideas. Because of evidence for a key role of the amygdala in fear and paranoia, resting-state functional connectivity of the amygdala was measured. Results: Connectivity between the amygdala and early visual cortical areas, including striate cortex (V1), was found to be significantly greater in participants with high (n = 43) v. low (n = 44) numbers of delusional beliefs, particularly in those who showed persistence of those beliefs. Similarly, across the full sample, the number of and distress associated with delusional beliefs were positively correlated with the strength of amygdala-visual cortex connectivity. Moreover, further analyses revealed that these effects were driven by those who endorsed persecutory beliefs. Conclusions: These findings are consistent with the hypothesis that aberrant assignments of threat to sensory stimuli may lead to the downstream development of delusional ideas. Taken together with prior findings of disrupted sensory-limbic coupling in psychosis, these results suggest that altered amygdala-visual cortex connectivity could represent a marker of psychosis-related pathophysiology across a continuum of symptom severity. [ABSTRACT FROM AUTHOR]

Published
2020
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133. PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia

Author

Gilbert, Tonya M., primary, Zürcher, Nicole R., additional, Wu, Christine J., additional, Bhanot, Anisha, additional, Hightower, Baileigh G., additional, Kim, Minhae, additional, Albrecht, Daniel S., additional, Wey, Hsiao-Ying, additional, Schroeder, Frederick A., additional, Rodriguez-Thompson, Anais, additional, Morin, Thomas M., additional, Hart, Kamber L., additional, Pellegrini, Amelia M., additional, Riley, Misha M., additional, Wang, Changning, additional, Stufflebeam, Steven M., additional, Haggarty, Stephen J., additional, Holt, Daphne J., additional, Loggia, Marco L., additional, Perlis, Roy H., additional, Brown, Hannah E., additional, Roffman, Joshua L., additional, and Hooker, Jacob M., additional

Published
2018
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136. CBT Delivered in a Specialized Depression Clinic for College Students with Depressive Symptoms

Author

Farabaugh, Amy, primary, Nyer, Maren B., additional, Holt, Daphne J., additional, Fisher, Lauren B., additional, Cheung, Joey C., additional, Anton, Jennifer, additional, Petrie, Samuel R., additional, Pedrelli, Paola, additional, Bentley, Kate, additional, Shapero, Benjamin G., additional, Baer, Lee, additional, Fava, Maurizio, additional, and Mischoulon, David, additional

Published
2018
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143. Correlation Between Levels of Delusional Beliefs and Perfusion of the Hippocampus and an Associated Network in a Non–Help-Seeking Population

Author

Wolthusen, Rick P.F., Coombs, Garth, Boeke, Emily A., Ehrlich, Stefan, DeCross, Stephanie N., Nasr, Shahin, and Holt, Daphne J.

Abstract

Delusions are a defining and common symptom of psychotic disorders. Recent evidence suggests that subclinical and clinical delusions may represent distinct stages on a phenomenological and biological continuum. However, few studies have tested whether subclinical psychotic experiences are associated with neural changes that are similar to those observed in clinical psychosis. For example, it is unclear if overactivity of the hippocampus, a replicated finding of neuroimaging studies of schizophrenia, is also present in individuals with subclinical psychotic symptoms.

Published
2024
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144. An Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflection

Author

Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Lee, Su Mei, Gabrieli, John D. E., Moran, Joseph M., Holt, Daphne J., Cassidy, Brittany S., Andrews-Hanna, Jessica R., Coombs, Garth, Goff, Donald C., Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Lee, Su Mei, Gabrieli, John D. E., Moran, Joseph M., Holt, Daphne J., Cassidy, Brittany S., Andrews-Hanna, Jessica R., Coombs, Garth, and Goff, Donald C.

Abstract

Background Deficits in social cognition, including impairments in self-awareness, contribute to the overall functional disability associated with schizophrenia. Studies in healthy subjects have shown that social cognitive functions, including self-reflection, rely on the medial prefrontal cortex (mPFC) and posterior cingulate gyrus, and these regions exhibit highly correlated activity during “resting” states. In this study, we tested the hypothesis that patients with schizophrenia show dysfunction of this network during self-reflection and that this abnormal activity is associated with changes in the strength of resting-state correlations between these regions. Methods Activation during self-reflection and control tasks was measured with functional magnetic resonance imaging in 19 patients with schizophrenia and 20 demographically matched control subjects. In addition, the resting-state functional connectivity of midline cortical areas showing abnormal self-reflection-related activation in schizophrenia was measured. Results Compared with control subjects, the schizophrenia patients demonstrated lower activation of the right ventral mPFC and greater activation of the mid/posterior cingulate gyri bilaterally during self-reflection, relative to a control task. A similar pattern was seen during overall social reflection. In addition, functional connectivity between the portion of the left mid/posterior cingulate gyrus showing abnormally elevated activity during self-reflection in schizophrenia, and the dorsal anterior cingulate gyrus was lower in the schizophrenia patients compared with control subjects. Conclusions Schizophrenia is associated with an anterior-to-posterior shift in introspection-related activation, as well as changes in functional connectivity, of the midline cortex. These findings provide support for the hypothesis that aberrant midline cortical function contributes to social cognitive impairment in schizophrenia., Poitras Center for Affective Disorders Research

Published
2016

145. Complexin2 modulates working memory-related neural activity in patients with schizophrenia

Author

Martinos Imaging Center (McGovern Institute for Brain Research at MIT), Harvard University--MIT Division of Health Sciences and Technology, McGovern Institute for Brain Research at MIT, Gollub, Randy L, Wolthusen, Rick, Ehrlich, Stefan, Hass, Johanna, Walton, Esther, Kirsten, Holger, Turner, Jessica, Roessner, Veit, Holt, Daphne, Sponheim, Scott R., Calhoun, Vince D., Gollub, Randy Lyanne, Martinos Imaging Center (McGovern Institute for Brain Research at MIT), Harvard University--MIT Division of Health Sciences and Technology, McGovern Institute for Brain Research at MIT, Gollub, Randy L, Wolthusen, Rick, Ehrlich, Stefan, Hass, Johanna, Walton, Esther, Kirsten, Holger, Turner, Jessica, Roessner, Veit, Holt, Daphne, Sponheim, Scott R., Calhoun, Vince D., and Gollub, Randy Lyanne

Abstract

The specific contribution of risk or candidate gene variants to the complex phenotype of schizophrenia is largely unknown. Studying the effects of such variants on brain function can provide insight into disease-associated mechanisms on a neural systems level. Previous studies found common variants in the complexin2 (CPLX2) gene to be highly associated with cognitive dysfunction in schizophrenia patients. Similarly, cognitive functioning was found to be impaired in Cplx2 gene-deficient mice if they were subjected to maternal deprivation or mild brain trauma during puberty. Here, we aimed to study seven common CPLX2 single-nucleotide polymorphisms (SNPs) and their neurogenetic risk mechanisms by investigating their relationship to a schizophrenia-related functional neuroimaging intermediate phenotype. We examined functional MRI and genotype data collected from 104 patients with DSM-IV-diagnosed schizophrenia and 122 healthy controls who participated in the Mind Clinical Imaging Consortium study of schizophrenia. Seven SNPs distributed over the whole CPLX2 gene were tested for association with working memory-elicited neural activity in a frontoparietal neural network. Three CPLX2 SNPs were significantly associated with increased neural activity in the dorsolateral prefrontal cortex and intraparietal sulcus in the schizophrenia sample, but showed no association in healthy controls. Since increased working memory-related neural activity in individuals with or at risk for schizophrenia has been interpreted as ‘neural inefficiency,’ these findings suggest that certain variants of CPLX2 may contribute to impaired brain function in schizophrenia, possibly combined with other deleterious genetic variants, adverse environmental events, or developmental insults., National Institutes of Health (U.S.) (Grant NIH/NCRR P41RR14075), United States. Dept. of Energy (Grant DE-FG02-99ER6276), Mind Research Network, Function BIRN (Grants U24RR021992-01 and NIH.NCRR MO1 RR025758-01), Brain & Behavior Research Foundation (Young Investigator Grant), Deutsche Forschungsgemeinschaft (Research Fellowship), Morphometry BIRN (Grant 1U24, RR021382A)

Published
2016

146. The Global Meningococcal Initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection

Author

Borrow, Ray, primary, Alarcón, Pedro, additional, Carlos, Josefina, additional, Caugant, Dominique A., additional, Christensen, Hannah, additional, Debbag, Roberto, additional, De Wals, Philippe, additional, Echániz-Aviles, Gabriela, additional, Findlow, Jamie, additional, Head, Chris, additional, Holt, Daphne, additional, Kamiya, Hajime, additional, Saha, Samir K, additional, Sidorenko, Sergey, additional, Taha, Muhamed-Kheir, additional, Trotter, Caroline, additional, Vázquez Moreno, Julio A., additional, von Gottberg, Anne, additional, and Sáfadi, Marco A. P., additional

Published
2016
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148. Contributing Authors

Author

Abrams, Annah N., Alpay, Menekse, Alpert, Jonathan E., Beach, Scott R., Beck, BJ, Beresin, Gene V., Berg, Sheri, Bianchi, Matt T., Bird, Suzanne A., Blais, Mark A., Brendel, Rebecca Weintraub, Brenner, Keri O., Bush, George, Camprodon, Joan A., Caplan, Jason P., Carlo, Andrew D., Cassano, Paolo, Celano, Christopher M., Chaukos, Deanna C., Chen, Justin A., Chu, Jacqueline T., Cohen, Lee S., Colvin, Mary K., Coniglio, Kathryn, Cremens, M. Cornelia, Cusin, Cristina, Donovan, Abigail L., Durham, Michelle P., Evins, A. Eden, Fava, Maurizio, Fernandez-Robles, Carlos G., Finn, Christine T., Flaherty, Alice W., Fox, Rosanna, Frates, Elizabeth Pegg, Freeman, Marlene P., Freudenreich, Oliver, Fricchione, Gregory L., Gholipour, Taha, Glass, Sean P., Goff, Donald C., Gordon, Christopher, Greenberg, Donna B., Gross, Anne F., Groves, James E., Hazen, Eric P., Henderson, David C., Henry, Michael E., Hogan, Charlotte, Holt, Daphne J., Huffman, Jeff C., Hurtado-Puerto, Aura M., Irwin, Kelly E., Israel, Esther Jacobowitz, Ivkovic, Ana, Januzzi, James L., Jr., Karamouz, Nasser, Katz, Tamar C., King, Franklin, IV, Koh, Katherine A., Kontos, Nicholas, Levine, John B., Lin, Kenny A., Linnoila, Jenny J., Lorberg, Boris A., Madu, Andrea, McCoy, Thomas H., Mischoulon, David, Nejad, Shamim H., Nisavic, Mladen, Nonacs, Ruta, Norman, Dennis K., O'Keefe, Sheila M., Otto, Michael W., Owusu, Micaela B., Papakostas, George I., Park, Elyse R., Perlis, Roy H., Pirl, William F., Pollack, Mark H., Prager, Laura M., Prince, Jefferson B., Querques, John, Quinn, Davin K., Robinson, Ellen M., Roffman, Joshua L., Rosenbaum, Jerrold F., Russell, Kristin, Safa, Kassem, Salinas, Joel, Schlozman, Steven C., Schouten, Ronald, Shafer, Linda C., Shapero, Benjamin G., Sherman, Janet, Smallwood, Patrick, Smith, Felicia A., Stern, Theodore A., Stevens, Jonathan R., Stoddard, Frederick J., Jr., Stoler, Joan M., Taylor, John B., Thomas, Jennifer J., Trinh, Nhi-Ha, Vance, Mary C., Vyas, Amy F., Wang, Betty, Weil, Eric M., Weissman, Anna R., Wiechers, Ilse R., Wilkins, James M., Wittmann, Curtis W., and Zayas, Lazaro V.

Published
2018
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