101. Relationship of dietary monounsaturated fatty acids to blood pressure
- Author
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Jeremiah Stamler, Katsuyuki Miura, Beatriz L. Rodriguez, J. David Curb, Claire E. Robertson, Akira Okayama, Liancheng Zhao, Nagako Okuda, Paul Elliott, Masaku Sakurai, Ian J. Brown, Hirotsugu Ueshima, Queenie Chan, Hideaki Nakagawa, and Lawrence J. Appel
- Subjects
Adult ,Male ,Epidemiologic study ,Physiology ,Cross-sectional study ,Population ,Blood Pressure ,Article ,Fatty Acids, Monounsaturated ,chemistry.chemical_compound ,Animal science ,Dietary Fats, Unsaturated ,Internal Medicine ,Animals ,Humans ,Medicine ,education ,education.field_of_study ,business.industry ,Confounding ,Middle Aged ,Micronutrient ,Oleic acid ,Cross-Sectional Studies ,Blood pressure ,Biochemistry ,chemistry ,Hypertension ,Linear Models ,Population study ,Female ,Cardiology and Cardiovascular Medicine ,business ,Oleic Acid - Abstract
Objective: In short-term feeding trials, replacement of other macronutrients with monounsaturated fatty acid reduces blood pressure. However, observational studies have not clearly demonstrated a relationship between monounsaturated fatty acid intake and blood pressure. We report associations of monounsaturated fatty acid intake of individuals with blood pressure in a cross-sectional study. Methods: The International Study of Macro/Micronutrients and Blood Pressure is a cross-sectional epidemiologic study of 4,680 men and women ages 40-59 from 17 population samples in China, Japan, United Kingdom, and United States. Nutrient intake data were based on four in-depth multi-pass 24-hour dietary recalls/person and two timed 24-hour urine collections/person. Blood pressure was measured eight times at four visits. Results: Mean monounsaturated fatty acid intake ranged from 8.1 %kcal (China) to 12.2%kcal (United States). With sequential models to control for possible confounders (dietary, other), linear regression analyses showed significant inverse relationship of total monounsaturated fatty acid intake with diastolic blood pressure for all participants; for 2,238 “non-intervened” individuals, the relationship was stronger. Estimated diastolic blood pressure differences with 2-SD higher monounsaturated fatty acids (5.35 %kcal) were -0.82 mm Hg (P
- Published
- 2013