101. Prediction of the incidence and persistence of allergic rhinitis in adolescence: a prospective cohort study.
- Author
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Kellberger J, Dressel H, Vogelberg C, Leupold W, Windstetter D, Weinmayr G, Genuneit J, Heumann C, Nowak D, von Mutius E, and Radon K
- Subjects
- Adolescent, Allergens immunology, Female, Germany epidemiology, Humans, Hypersensitivity immunology, Incidence, Logistic Models, Male, Prospective Studies, Rhinitis immunology, Risk Factors, Skin Tests, Hypersensitivity epidemiology, Rhinitis epidemiology
- Abstract
Background: Predictive models have rarely been used in allergy research and practice. However, they might support physicians in advising patients., Objective: The aim of this study was to create predictive models for the incidence and persistence of allergic rhinitis (AR) during adolescence., Methods: A prospective population-based cohort study was conducted starting at age 9 to 11 years. Potential risk factors for atopic diseases obtained at baseline in 2810 subjects were used to create predictive logistic regression models for the incidence and persistence of physician-diagnosed AR with current symptoms at age 15 to 18 years., Results: Positive skin prick test responses to outdoor allergens at baseline were the most important determinant for both the incidence and persistence of AR until follow-up. For the incidence of AR, positive skin prick test responses to indoor allergens, parental history of asthma, female sex, and not having been breast-fed exclusively for 2 or more months were additional statistically significant independent risk factors. Depending on the number of risk factors present, the probability of the incidence of AR increased from 2% (no risk factors present) to 72% (full model; 95% CI, 58% to 85%). The probability of persistence of AR ranged from 33% (no risk factors present) to 83% (full model; 95% CI, 70% to 97%)., Conclusion: The course of AR over puberty can be predicted using risk factors that are easy to determine in childhood. Sensitization to outdoor allergens seems to play a much greater role for disease development than sensitization to indoor allergens. This might help pediatricians in advising patients., (Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.)
- Published
- 2012
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