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101. Endovascular Therapy vs. Best Medical Management in Distal Medium Middle Cerebral Artery Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study

Author

Salim, Hamza A., primary, Yedavalli, Vivek, additional, Musmar, Basel, additional, Adeeb, Nimer, additional, Naamani, Kareem El, additional, Henninger, Nils, additional, Sundararajan, Sri Hari, additional, Kuhn, Anna Luisa, additional, Khalife, Jane, additional, Ghozy, Sherief, additional, Scarcia, Luca, additional, Tan, Benjamin YQ, additional, Heit, Jeremy J., additional, Regenhardt, Robert, additional, Cancelliere, Nicole M., additional, Bernstock, Joshua D., additional, Rouchaud, Aymeric, additional, Fiehler, Jens, additional, Sheth, Sunil A., additional, Essibayi, Muhammed Amir, additional, Puri, Ajit S., additional, Dyzmann, Christian, additional, Colasurdo, Marco, additional, Barreau, Xavier, additional, Renieri, Leonardo, additional, Filipe, João Pedro, additional, Harker, Pablo, additional, Radu, Răzvan Alexandru, additional, Marotta, Thomas R., additional, Spears, Julian, additional, Ota, Takahiro, additional, Mowla, Ashkan, additional, Jabbour, Pascal M., additional, Biswas, Arundhati, additional, Clarençon, Frédéric, additional, Siegler, James E., additional, Nguyen, Thanh N., additional, Varela, Ricardo, additional, Baker, Amanda, additional, Altschul, David, additional, Gonzalez, Nestor R., additional, Mohlenbruch, Markus, additional, Costalat, Vincent, additional, Gory, Benjamin, additional, Stracke, Christian Paul, additional, Aziz-Sultan, Ali, additional, Hecker, Constantin, additional, Shaikh, Hamza, additional, Liebeskind, David S., additional, Pedicelli, Alessandro, additional, Alexandre, Andrea M., additional, Tancredi, Illario, additional, Faizy, Tobias D., additional, Kalsoum, Erwah, additional, Lubicz, Boris, additional, Patel, Aman B., additional, Pereira, Vitor Mendes, additional, Guenego, Adrien, additional, and Dmytriw, Adam A., additional

Published
2024
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102. Diagnosis and endovascular management of vasospasm after aneurysmal subarachnoid hemorrhage -- survey of real-life practices.

Author

Guenego, Adrien, Fahed, Robert, Rouchaud, Aymeric, Walker, Gregory, Faizy, Tobias D., Sporns, Peter B., Aggour, Mohamed, Jabbour, Pascal, Alexandre, Andrea M., Mosimann, Pascal John, Dmytriw, Adam A., Ligot, Noémie, Sadeghi, Niloufar, Chengbo Dai, Hassan, Ameer E., Pereira, Vitor M., Singer, Justin, Heit, Jeremy J., Taccone, Fabio Silvio, and Chen, Michael

Subjects
INTRACRANIAL aneurysms, NIMODIPINE, CEREBRAL vasospasm, NEUROLOGISTS, SUBARACHNOID hemorrhage, QUESTIONNAIRES, ANGIOPLASTY, ENDOVASCULAR surgery, DESCRIPTIVE statistics, TRANSCRANIAL Doppler ultrasonography, PHYSICIAN practice patterns, DISEASE complications
Abstract

Background Vasospasm and delayed cerebral ischemia (DCI) are the leading causes of morbidity and mortality after intracranial aneurysmal subarachnoid hemorrhage (aSAH). Vasospasm detection, prevention and management, especially endovascular management varies from center to center and lacks standardization. We aimed to evaluate this variability via an international survey of how neurointerventionalists approach vasospasm diagnosis and endovascular management. Methods We designed an anonymous online survey with 100 questions to evaluate practice patterns between December 2021 and September 2022. We contacted endovascular neurosurgeons, neuroradiologists and neurologists via email and via two professional societies -- the Society of NeuroInterventional Surgery (SNIS) and the European Society of Minimally Invasive Neurological Therapy (ESMINT). We recorded the physicians' responses to the survey questions. Results A total of 201 physicians (25% [50/201] USA and 75% non-USA) completed the survey over 10 months, 42% had >7 years of experience, 92% were male, median age was 40 (IQR 35-46). Both high-volume and low- volume centers were represented. Daily transcranial Doppler was the most common screening method (75%) for vasospasm. In cases of symptomatic vasospasm despite optimal medical management, endovascular treatment was directly considered by 58% of physicians. The most common reason to initiate endovascular treatment was clinical deficits associated with proven vasospasm/DCI in 89%. The choice of endovascular treatment and its efficacy was highly variable. Nimodipine was the most common first- line intra-arterial therapy (40%). Mechanical angioplasty was considered the most effective endovascular treatment by 65% of neurointerventionalists. Conclusion Our study highlights the considerable heterogeneity among the neurointerventional community regarding vasospasm diagnosis and endovascular management. Randomized trials and guidelines are needed to improve standard of care, determine optimal management approaches and track outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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103. Matched-pair analysis of patients with ischemic stroke undergoing thrombectomy using next-generation balloon guide catheters.

Author

Kim, Lily H., Choi, John, Zhou, James, Wolman, Dylan, Pendharkar, Arjun V., Lansberg, Maarten G., Albers, Gregory W., Dodd, Robert, Do, Huy M., Pulli, Benjamin, Heit, Jeremy J., and Telischak, Nicholas A.

Subjects
T-test (Statistics), STATISTICAL significance, PAIRED comparisons (Mathematics), SEX distribution, MULTIPLE regression analysis, TREATMENT effectiveness, RETROSPECTIVE studies, AGE distribution, CHI-squared test, MANN Whitney U Test, MULTIVARIATE analysis, DESCRIPTIVE statistics, SURGICAL complications, ODDS ratio, ISCHEMIC stroke, CATHETERS, MEDICAL records, ACQUISITION of data, STATISTICS, THROMBECTOMY, CONFIDENCE intervals, DATA analysis software
Abstract

Background Balloon guide catheters (BGCs) have not been widely adopted, possibly due to the incompatibility of past-generation BGCs with large-bore intermediate catheters. The next-generation BGC is compatible with large-bore catheters. We compared outcomes of thrombectomy cases using BGCs versus conventional guide catheters. Methods We conducted a retrospective study of 110 thrombectomy cases using BGCs (n=55) and non-BGCs (n=55). Sixty consecutive thrombectomy cases in whom the BOBBY BGC was used at a single institution between February 2021 and March 2022 were identified. Of these, 55 BGC cases were 1:1 matched with non-BGC cases by proceduralists, age, gender, stent retriever + aspiration device versus aspiration-only, and site of occlusion. First-pass effect was defined as Thrombolysis In Cerebral Infarction 2b or higher with a single pass. Results The BGC and non-BGC cohorts had similar mean age (67.2 vs 68.9 years), gender distribution (43.6% vs 47.3% women), median initial National Institutes of Health Stroke Scale score (14 vs 15), and median pretreatment ischemic core volumes (12 mL vs 11.5 mL). BGC and non-BGC cases had similar rates of single pass (60.0% vs 54.6%), first-pass effect (58.2% vs 49.1%), and complications (1.8% vs 9.1%). In aspiration-only cases, the BGC cohort had a significantly higher rate of first-pass effect (100% vs 50.0%, p=0.01). BGC was associated with a higher likelihood of achieving a modified Rankin Scale score of 2 at discharge (OR 7.76, p=0.02). No additional procedural time was required for BGC cases (46.7 vs 48.2 min). Conclusion BGCs may be safely adopted with comparable procedural efficacy, benefits to aspirationonly techniques, and earlier functional improvement compared with conventional guide catheters. [ABSTRACT FROM AUTHOR]

Published
2024
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104. Mechanical thrombectomy in anterior vs. posterior circulation stroke: A systematic review and meta-analysis.

Author

Adusumilli, Gautam, Pederson, John M, Hardy, Nicole, Kallmes, Kevin M, Hutchison, Kristen, Kobeissi, Hassan, Heiferman, Daniel M, and Heit, Jeremy J

Subjects
BASILAR artery, ISCHEMIC stroke, RANDOM effects model, THROMBECTOMY, CEREBRAL infarction
Abstract

Background: High-quality evidence exists for mechanical thrombectomy (MT) treatment of acute ischemic stroke (AIS) due to large vessel occlusion of the anterior circulation (AC-LVO). The evidence for MT treatment of posterior circulation large vessel occlusion (PC-LVO) is weaker, largely drawn from lower quality studies specific to PC-LVO and extrapolated from findings in AC-LVO, and ambiguous with regards to technical success. We performed a systematic review and meta-analysis to compare the technical success and functional outcomes of MT in PC-LVO versus AC-LVO patients. Methods: We identified comparative studies reporting on patients treated with MT in AC-LVO versus PC-LVO. The primary outcome of interest was thrombolysis in cerebral infarction (TICI) ≥ 2b. Secondary outcomes included rates of TICI 3, 90-day functional independence, first-pass-effect, average number of passes, and 90-day mortality. A separate random effects model was fit for each outcome measure. Results: Twenty studies with 12,911 patients, 11,299 (87.5%) in the AC-LVO arm and 1612 (12.5%) in the PC-LVO arm, were included. AC-LVO and PC-LVO patients had comparable rates of successful recanalization [OR = 1.02 [95% CI: 0.79–1.33], p = 0.848). However, the AC-LVO group had greater odds of 90-day functional independence (OR = 1.26 [95% CI: 1.00; 1.59], p = 0.050) and lower odds of 90-day mortality (OR = 0.58 [95% CI: 0.43; 0.79], p = 0.002). Conclusions: MT achieves similar rates of recanalization with a similar safety profile in PC-LVO and AC-LVO patients. Patients with PC-LVO are less likely to achieve functional independence after MT. Future studies should identify PC-LVO patients who are likely to achieve favourable functional outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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106. Redefining CT perfusion‐based ischemic core estimates for the ghost core in early time window stroke

Author

Koneru, Manisha, primary, Hoseinyazdi, Meisam, additional, Lakhani, Dhairya A., additional, Greene, Cynthia, additional, Copeland, Karen, additional, Wang, Richard, additional, Xu, Risheng, additional, Luna, Licia, additional, Caplan, Justin M., additional, Dmytriw, Adam A., additional, Guenego, Adrien, additional, Heit, Jeremy J., additional, Albers, Gregory W., additional, Wintermark, Max, additional, Gonzalez, Luis F., additional, Urrutia, Victor C., additional, Huang, Judy, additional, Nael, Kambiz, additional, Leigh, Richard, additional, Marsh, Elisabeth B., additional, Hillis, Argye E., additional, Llinas, Rafael H., additional, and Yedavalli, Vivek S., additional

Published
2023
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107. Early neurological deterioration in patients with acute ischemic stroke is linked to unfavorable cerebral venous outflow

Author

Heitkamp, Christian, primary, Winkelmeier, Laurens, additional, Heit, Jeremy J, additional, Albers, Gregory W, additional, Lansberg, Maarten G, additional, Kniep, Helge, additional, Broocks, Gabriel, additional, Stracke, Christian Paul, additional, Schell, Maximilian, additional, Guenego, Adrien, additional, Paech, Daniel, additional, Wintermark, Max, additional, Fiehler, Jens, additional, and Faizy, Tobias D, additional

Published
2023
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108. Pretreatment CT perfusion collateral parameters correlate with penumbra salvage in middle cerebral artery occlusion

Author

Lakhani, Dhairya A., primary, Balar, Aneri B., additional, Koneru, Manisha, additional, Hoseinyazdi, Meisam, additional, Hyson, Nathan, additional, Cho, Andrew, additional, Greene, Cynthia, additional, Xu, Risheng, additional, Luna, Licia, additional, Caplan, Justin, additional, Dmytriw, Adam, additional, Guenego, Adrien, additional, Wintermark, Max, additional, Gonzalez, Fernando, additional, Urrutia, Victor, additional, Huang, Judy, additional, Nael, Kambiz, additional, Rai, Ansaar T., additional, Albers, Gregory W., additional, Heit, Jeremy J., additional, and Yedavalli, Vivek, additional

Published
2023
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109. Larger ischemic cores and poor collaterals among large vessel occlusions presenting in the late evening

Author

Sreekrishnan, Anirudh, primary, Tiedt, Steffen, additional, Seners, Pierre, additional, Yuen, Nicole, additional, Olivot, Jean-Marc, additional, Mlynash, Michael, additional, Lansberg, Maarten G., additional, Heit, Jeremy J., additional, Lee, Sarah, additional, Michel, Patrik, additional, Strambo, Davide, additional, Salerno, Alexander, additional, Paredes, José Bernardo Escribano, additional, Carrera, Emmanuel, additional, and Albers, Gregory W., additional

Published
2023
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111. Robust Collaterals Are Independently Associated With Excellent Recanalization in Patients With Large Vessel Occlusion Causing Acute Ischemic Stroke

Author

Yedavalli, Vivek, primary, Koneru, Manisha, additional, Hoseinyazdi, Meisam, additional, Greene, Cynthia, additional, Copeland, Karen, additional, Xu, Risheng, additional, Luna, Licia, additional, Caplan, Justin, additional, Dmytriw, Adam, additional, Guenego, Adrien, additional, Heit, Jeremy, additional, Albers, Gregory, additional, Wintermark, Max, additional, Gonzalez, Luis Fernando, additional, Urrutia, Victor, additional, Huang, Judy, additional, Leigh, Richard, additional, Marsh, Elisabeth, additional, Llinas, Rafael, additional, Hillis, Argye, additional, and Nael, Kambiz, additional

Published
2023
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112. Performance of RAPID noncontrast CT stroke platform in large vessel occlusion and intracranial hemorrhage detection

Author

Yedavalli, Vivek, primary, Heit, Jeremy Josef, additional, Dehkharghani, Seena, additional, Haerian, Hafez, additional, Mcmenamy, John, additional, Honce, Justin, additional, Timpone, Vincent M., additional, Harnain, Christopher, additional, Kesselman, Andrew, additional, Filly, Anthony, additional, Beardsley, Adam, additional, Sakamoto, Brian, additional, Song, Chris, additional, Montuori, James, additional, Navot, Benjamin, additional, Mena, Francisco Villar, additional, Giurgiutiu, Dan-Victor, additional, Kitamura, Felipe, additional, Lima, Fabricio Oliveira, additional, Silva, Henrique, additional, Mont’Alverne, Francisco Jose, additional, and Albers, Gregory, additional

Published
2023
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124. Detection of Cardiac Incidental Findings on Routine Chest CT: The Impact of Dedicated Training in Cardiac Imaging

Author

Bennett, Debbie, Choy, Garry, Cooley, Michael, Czuczman, Gregory, Digumarthy, Subba, Fintelmann, Florian, Govindan, Siddarth, Heit, Jeremy, Iqbal, Shams, Kallianos, Kim, Kim, Phillip, Little, Brent, Quencer, Keith, Rojas, Carlos, Simeone, F. Joseph, Venkatesh, Vikram, Vorasettakarnkij, Yongkasem, Verdini, Daniel, Lee, Ashley M., Prabhakar, Anand M., Abbara, Suhny, and Ghoshhajra, Brian

Published
2018
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125. Proposed achievable levels of dose and impact of dose-reduction systems for thrombectomy in acute ischemic stroke: an international, multicentric, retrospective study in 1096 patients

Author

Guenego, Adrien, Mosimann, Pascal J., Pereira, Vitor Mendes, Nicholson, Patrick, Zuber, Kevin, Lotterie, Jean Albert, Dobrocky, Tomas, Marcellus, David G., Olivot, Jean Marc, Piotin, Michel, Gralla, Jan, Fahed, Robert, Wintermark, Max, Heit, Jeremy J., Cognard, Christophe, and on behalf of the RADON Investigators

Published
2019
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129. First pass effect as an independent predictor of functional outcomes in medium vessel occlusions: An analysis of an international multicenter study

Author

Radu, Răzvan Alexandru, primary, Costalat, Vincent, additional, Fahed, Robert, additional, Ghozy, Sherief, additional, Siegler, James E, additional, Shaikh, Hamza, additional, Khalife, Jane, additional, Abdalkader, Mohamad, additional, Klein, Piers, additional, Nguyen, Thanh N, additional, Heit, Jeremy J, additional, Sweid, Ahmad, additional, El Naamani, Kareem, additional, Regenhardt, Robert W, additional, Diestro, Jose Danilo Bengzon, additional, Cancelliere, Nicole M, additional, Amllay, Abdelaziz, additional, Meyer, Lukas, additional, Dusart, Anne, additional, Bellante, Flavio, additional, Forestier, Géraud, additional, Rouchaud, Aymeric, additional, Saleme, Suzana, additional, Mounayer, Charbel, additional, Fiehler, Jens, additional, Kühn, Anna Luisa, additional, Puri, Ajit S, additional, Dyzmann, Christian, additional, Kan, Peter T, additional, Colasurdo, Marco, additional, Marnat, Gaultier, additional, Berge, Jérôme, additional, Barreau, Xavier, additional, Sibon, Igor, additional, Nedelcu, Simona, additional, Henninger, Nils, additional, Kyheng, Maéva, additional, Marotta, Thomas R, additional, Stapleton, Christopher J, additional, Rabinov, James D, additional, Ota, Takahiro, additional, Dofuku, Shogo, additional, Yeo, Leonard LL, additional, Tan, Benjamin YQ, additional, Martinez-Gutierrez, Juan Carlos, additional, Salazar-Marioni, Sergio, additional, Sheth, Sunil, additional, Renieri, Leonardo, additional, Capirossi, Carolina, additional, Mowla, Ashkan, additional, Tjoumakaris, Stavropoula I, additional, Jabbour, Pascal, additional, Khandelwal, Priyank, additional, Biswas, Arundhati, additional, Clarençon, Frédéric, additional, Elhorany, Mahmoud, additional, Premat, Kevin, additional, Valente, Iacopo, additional, Pedicelli, Alessandro, additional, Pedro Filipe, João, additional, Varela, Ricardo, additional, Quintero-Consuegra, Miguel, additional, Gonzalez, Nestor R, additional, Möhlenbruch, Markus A, additional, Jesser, Jessica, additional, Tancredi, Illario, additional, ter Schiphorst, Adrien, additional, Yedavalli, Vivek, additional, Harker, Pablo, additional, Chervak, Lina M, additional, Aziz, Yasmin, additional, Gory, Benjamin, additional, Paul Stracke, Christian, additional, Hecker, Constantin, additional, Killer-Oberpfalzer, Monika, additional, Griessenauer, Christoph J, additional, Thomas, Ajith J, additional, Hsieh, Cheng-Yang, additional, Liebeskind, David S, additional, Alexandre, Andrea M, additional, Faizy, Tobias D, additional, Weyland, Charlotte, additional, Patel, Aman B, additional, Pereira, Vitor Mendes, additional, Lubicz, Boris, additional, Dmytriw, Adam A, additional, and Guenego, Adrien, additional

Published
2023
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130. Matched-pair analysis of patients with ischemic stroke undergoing thrombectomy using next-generation balloon guide catheters

Author

Kim, Lily H, primary, Choi, John, additional, Zhou, James, additional, Wolman, Dylan, additional, Pendharkar, Arjun V, additional, Lansberg, Maarten G, additional, Albers, Gregory W, additional, Dodd, Robert, additional, Do, Huy M, additional, Pulli, Benjamin, additional, Heit, Jeremy J, additional, and Telischak, Nicholas A, additional

Published
2023
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133. Pretreatment and interventional parameters predict excellent recanalization of large vessel occlusion in patients with acute ischemic stroke

Author

Yedavalli, Vivek, primary, Koneru, Manisha, additional, Hoseinyazdi, Meisam, additional, Greene, Cynthia, additional, Copeland, Karen, additional, Xu, Risheng, additional, Luna, Licia, additional, Caplan, Justin, additional, Dmytriw, Adam, additional, Guenego, Adrien, additional, Heit, Jeremy, additional, Albers, Gregory, additional, Wintermark, Max, additional, Gonzalez, Fernando, additional, Urrutia, Victor, additional, Huang, Judy, additional, Leigh, Richard, additional, Marsh, Elisabeth, additional, Llinas, Rafael, additional, Hillis, Argye, additional, and Nael, Kambiz, additional

Published
2023
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136. Association Between Net Water Uptake and Functional Outcome in Patients With Low ASPECTS Brain Lesions

Author

Broocks, Gabriel, Meyer, Lukas, Elsayed, Sarah, McDonough, Rosalie, Bechstein, Matthias, Faizy, Tobias Djamsched, Sporns, Peter, Schön, Gerhard, Minnerup, Jens, Kniep, Helge C., Hanning, Uta, Barow, Ewgenia, Schramm, Peter, Langner, Soenke, Nawabi, Jawed, Papanagiotou, Panagiotis, Wintermark, Max, Lansberg, Maarten G., Albers, Gregory W., Heit, Jeremy J., Fiehler, Jens, and Kemmling, Andre

Subjects
Neurology (clinical), Research Article
Abstract

Background and ObjectivesThe effect of mechanical thrombectomy (MT) on functional outcome in patients with ischemic stroke with low ASPECTS is still uncertain. ASPECTS rating is based on the presence of ischemic hypoattenuation relative to normal; however, the degree of hypoattenuation, which directly reflects net uptake of water, is currently not considered an imaging biomarker in stroke triage. We hypothesized that the effect of thrombectomy on functional outcome in low ASPECTS patients depends on early lesion water uptake.MethodsFor this multicenter observational study, patients with anterior circulation stroke with ASPECTS ≤5 were consecutively analyzed. Net water uptake (NWU) was assessed as a quantitative imaging biomarker in admission CT. The primary end point was the rate of favorable functional outcome defined as modified Rankin Scale score 0–3 at day 90. The effect of recanalization on functional outcome was analyzed according to the degree of NWU within the early infarct lesion.ResultsA total of 254 patients were included, of which 148 (58%) underwent MT. The median ASPECTS was 4 (interquartile range [IQR] 3–5), and the median NWU was 11.4% (IQR 8.9%–15.1%). The rate of favorable outcome was 27.6% in patients with low NWU (p< 0.0001). In multivariable logistic regression analysis, NWU was an independent predictor of outcome, whereas vessel recanalization (modified thrombolysis in cerebral infarction ≥2b) was only significantly associated with better outcomes if NWU was lower than 12.6%. In inverse-probability weighting analysis, recanalization was associated with 20.7% (p= 0.01) increase in favorable outcome in patients with low NWU compared with 9.1% (p= 0.06) in patients with high NWU.DiscussionEarly NWU was independently associated with clinical outcome and might serve as an indicator of futile MT in low ASPECTS patients. NWU could be tested as a tool to select low ASPECTS patients for MT.Trial Registration InformationThe study is registered within theClinicalTrials.govProtocol Registration and Results System (NCT04862507).

Published
2022
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140. Redefining CT perfusion‐based ischemic core estimates for the ghost core in early time window stroke.

Author

Koneru, Manisha, Hoseinyazdi, Meisam, Lakhani, Dhairya A., Greene, Cynthia, Copeland, Karen, Wang, Richard, Xu, Risheng, Luna, Licia, Caplan, Justin M., Dmytriw, Adam A., Guenego, Adrien, Heit, Jeremy J., Albers, Gregory W., Wintermark, Max, Gonzalez, Luis F., Urrutia, Victor C., Huang, Judy, Nael, Kambiz, Leigh, Richard, and Marsh, Elisabeth B.

Subjects
CEREBRAL circulation, STROKE patients, PERFUSION, RANK correlation (Statistics), REPERFUSION
Abstract

Background and Purpose: In large vessel occlusion (LVO) stroke patients, relative cerebral blood flow (rCBF)<30% volume thresholds are commonly used in treatment decisions. In the early time window, nearly infarcted but salvageable tissue volumes may lead to pretreatment overestimates of infarct volume, and thus potentially exclude patients who may otherwise benefit from intervention. Our multisite analysis aims to explore the strength of relationships between widely used pretreatment CT parameters and clinical outcomes for early window stroke patients. Methods: Patients from two sites in a prospective registry were analyzed. Patients with LVOs, presenting within 3 hours of last known well, and who were successfully reperfused were included. Primary short‐term neurological outcome was percent National Institutes of Health Stroke Scale (NIHSS) change from admission to discharge. Secondary long‐term outcome was 90‐day modified Rankin score. Spearman's correlations were performed. Significance was attributed to p‐value ≤.05. Results: Among 73 patients, median age was 66 (interquartile range 54‐76) years. Among all pretreatment imaging parameters, rCBF<30%, rCBF<34%, and rCBF<38% volumes were significantly, inversely correlated with percentage NIHSS change (p<.048). No other parameters significantly correlated with outcomes. Conclusions: Our multisite analysis shows that favorable short‐term neurological recovery was significantly correlated with rCBF volumes in the early time window. However, modest strength of correlations provides supportive evidence that the applicability of general ischemic core estimate thresholds in this subpopulation is limited. Our results support future larger‐scale efforts to liberalize or reevaluate current rCBF parameter thresholds guiding treatment decisions for early time window stroke patients. [ABSTRACT FROM AUTHOR]

Published
2024
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150. CT Perfusion vs Noncontrast CT for Late Window Stroke Thrombectomy

Author

Kobeissi, Hassan, primary, Ghozy, Sherief, additional, Adusumilli, Gautam, additional, Bilgin, Cem, additional, Tolba, Hatem, additional, Amoukhteh, Melika, additional, Kadirvel, Ramanathan, additional, Brinjikji, Waleed, additional, Heit, Jeremy J., additional, Rabinstein, Alejandro A., additional, and Kallmes, David F., additional

Published
2023
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