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The safety and efficacy of genome editing in human embryos hasn’t been proven, researchers warn. The safety and efficacy of genome editing in human embryos hasn’t been proven, researchers warn.

Researchers call for more rigorous clinical trials as rumours abound that US regulators are considering widening access to the potential therapy. Researchers call for more rigorous clinical trials as rumours swirl that US regulators might authorize the potential therapy.

Monoclonal antibodies are complex and expensive to produce, meaning poor countries might be priced out. Monoclonal antibodies are complex and expensive to produce, meaning poor countries might be priced out.

From immunity to the role of genetics, Nature looks at five pressing questions about COVID-19 that researchers are tackling. Six months into the outbreak, Nature looks at the pressing questions that researchers are tackling.

A new breed of researcher is turning to computation to understand society — and then change it. A new breed of researcher is turning to computation to understand society — and then change it.

Remote clinical trials and other changes could permanently alter pharmaceutical development: part 7 in a series on science after the pandemic. Remote clinical trials and other changes could permanently alter pharmaceutical development: part 7 in a series on science after the pandemic.

Retracted studies had relied on health-record analyses from a company that declined to share its raw data for an audit. Retracted studies had relied on health-record analyses from a company that declined to share its raw data for an audit.

Strained health-care systems, lockdowns and safety requirements have hampered efforts to collect tissue from patients that is crucial to research. Strained health-care systems, lockdowns and safety requirements have hampered efforts to collect tissue from patients that is crucial to research.

Despite conflicting studies, results from largest trial yet show the antiviral speeds up recovery, putting it on track to become a standard of care in the United States. Despite conflicting studies, results from largest trial yet show the antiviral speeds up recovery, putting it on track to become a standard of care in the United States.

Doctors are reaching for drugs that dampen the immune response — but these also undermine the body’s own fight against the coronavirus. Uncertainty is hampering doctors’ ability to choose treatments.

Studies grind to a halt as fears of health-care shortages and risk of exposure put the brakes on clinical research. Studies grind to a halt as fears of health-care shortages and risk of exposure put the brakes on clinical research.

Improvements to a method known as base editing could pave the way for safer gene therapies. Improvements to a method known as base editing could pave the way for safer gene therapies.

Wildfires, cosmic rays and ancient-human hybrids are some of this year’s top stories. Wildfires, cosmic rays and ancient-human hybrids are some of this year’s top stories.

Participants in medical research are more empowered than ever to influence the design and outcomes of experiments. Now, researchers are trying to keep up. Participants in medical research are more empowered than ever to influence the design and outcomes of experiments. Now, researchers are trying to keep up.

Medical researchers are beginning to shift their focus away from COVID-19 — but the pandemic could continue to affect studies focused on other diseases. Medical researchers are beginning to shift their focus away from COVID-19 — but the pandemic could continue to affect studies focused on other diseases.

As safety concerns delay the use of two COVID-19 vaccines, Nature looks at the questions that scientists want answered. As safety concerns delay the use of two COVID-19 vaccines, Nature looks at the questions that scientists want answered.

Researchers are searching for possible links between unusual clotting and the Oxford–AstraZeneca coronavirus vaccine. Researchers are searching for possible links between unusual clotting and the Oxford–AstraZeneca coronavirus vaccine.

David Julius and Ardem Patapoutian share the award for identifying receptors that allow the body’s cells to sense temperature and touch. David Julius and Ardem Patapoutian share the award for identifying receptors that allow the body’s cells to sense temperature and touch.

But uptake by patients and physicians has been low in the United States, where some therapies have been authorized for months. But uptake by patients and physicians has been low in the United States, where some therapies have been authorized for months.

Despite the widespread roll-out of several vaccines, it could be months before they can be ranked. Despite the widespread roll-out of several vaccines, it could be months before they can be ranked.

In the race against emerging coronavirus variants, researchers are looking beyond antibodies for clues to lasting protection from COVID-19. In the race against emerging coronavirus variants, researchers are looking beyond antibodies for clues to lasting protection from COVID-19.

Lineages that can evade immunity are spurring vaccine makers to explore ways to redesign their shots. Lineages that can evade immunity are spurring vaccine makers to explore ways to redesign their shots.

Studies find that overall risk of death or severe disease from COVID-19 is very low in kids. Studies find that overall risk of death or severe disease from COVID-19 is very low in kids.

A giant iceberg, a quantum-entanglement experiment and the death of a spacecraft are among the year’s top stories. A giant iceberg, a quantum-entanglement experiment and the death of a spacecraft are among the year’s top stories.

Epigenetic discoveries are fuelling renewed interest in the fusion proteins that have bedevilled cancer biologists.

The FDA has issued an emergency-use authorization for the Pfizer–BioNTech vaccine. Regulators are gearing up to look for side effects. The FDA has issued an emergency-use authorization for the Pfizer–BioNTech vaccine. Regulators are gearing up to look for side effects.

The Oxford–AstraZeneca partnership is the first major developer to publish detailed data from phase III trials. The Oxford–AstraZeneca partnership is the first major developer to publish detailed data from phase III trials.

Heartbreak, sacrifice, genetics and venture philanthropy — this book has it all. Heartbreak, sacrifice, genetics and venture philanthropy — this book has it all.

Emmanuelle Charpentier and Jennifer Doudna share the award for developing the precise genome-editing technology. Emmanuelle Charpentier and Jennifer Doudna share the award for developing the precise genome-editing technology.

Researchers warn that vaccines could stumble on safety trials, be fast-tracked because of politics or fail to meet the public’s expectations. Researchers warn that vaccines could stumble on safety trials, be fast-tracked because of politics or fail to meet the public’s expectations.

A Second World War disaster fuelled the crusade for cancer treatment, Jennet Conant’s book argues. A Second World War disaster fuelled the crusade for cancer treatment, Jennet Conant’s book argues.

Second infections raise questions about long-term immunity to COVID-19 and the prospects for a vaccine. Second infections raise questions about long-term immunity to COVID-19 and the prospects for a vaccine.

Viral immunologists say that results so far have been predictable — here’s why that’s good news. Viral immunologists say that results so far have been predictable — here’s why that’s good news.

Three studies showing large DNA deletions and reshuffling heighten safety concerns about heritable genome editing. Three studies showing large DNA deletions and reshuffling heighten safety concerns about heritable genome editing.

A study that suggested using hydroxychloroquine — a malaria drug — to treat people with COVID-19 could be dangerous has slowed clinical trials, but the study itself has also been questioned. A study that suggested using hydroxychloroquine — a malaria drug — to treat people with COVID-19 could be dangerous has slowed clinical trials, but the study itself has also been questioned.

Drug manufacturers face supply-chain weaknesses and sourcing issues as they ramp up complex production processes to meet global demand. Drug manufacturers face supply-chain weaknesses and sourcing issues as they ramp up complex production processes to meet global demand.

Advances in genomics and imaging are reviving a fading discipline. Advances in genomics and imaging are reviving a fading discipline.

Scientists fear the controversy over the Nightingale project will undermine trust in research. The Nghtingale project gives Google access to information on tens of millions of people.

Trump has nominated cancer physician Stephen Hahn to lead a food and drug agency in turmoil. Trump has nominated cancer physician Stephen Hahn to lead a food and drug agency in turmoil.

The collaborators will take advantage of recent advances in cancer genetics and imaging. The collaborators will take advantage of recent advances in cancer genetics and imaging.

As lung injuries among e-cigarette users mount amid a youth vaping epidemic, the impact of new restrictions remains unclear. As lung injuries among e-cigarette users mount amid a youth vaping epidemic, the impact of new restrictions remains unclear.

Startling discovery could open up avenues for treating some aggressive tumours. Startling discovery could open up avenues for treating some aggressive tumours.

Analysis using CRISPR gene-editing technology suggests that drugs’ mechanism of action are misunderstood. Analysis using CRISPR gene-editing technology suggests that drugs’ mechanism of action are misunderstood.

Confidence in researchers might be on the rise, but concerns about misconduct and potential conflicts of interest remain. Confidence in researchers might be on the rise, but concerns about misconduct and potential conflicts of interest remain.